Genomes and Genes
Gene Symbol: Gpr50
Description: G-protein-coupled receptor 50
Alias: melatonin-related receptor
- Hand L, Saer B, Hui S, Jinnah H, Steinlechner S, Loudon A, et al. Induction of the metabolic regulator Txnip in fasting-induced and natural torpor. Endocrinology. 2013;154:2081-91 pubmed publisher..We recently showed that mice lacking the orphan G protein-coupled receptor Gpr50 readily enter torpor in response to fasting and have now used these mice to conduct a microarray analysis of ..
- Ma Y, Wu Z, Feng Y, Xiao Z, Qin X, Ma Q. G protein coupled receptor 50 promotes self-renewal and neuronal differentiation of embryonic neural progenitor cells through regulation of notch and wnt/Î²-catenin signalings. Biochem Biophys Res Commun. 2015;458:836-42 pubmed publisherG protein-coupled receptor 50 (GPR50), a risk factor for major depressive disorder and bipolar affective disorder, is expressed in both the developmental and adult brain. However, the function of GPR50 in the brain remains unknown...
- Feng W, Leach S, Tipney H, Phang T, Geraci M, Spritz R, et al. Spatial and temporal analysis of gene expression during growth and fusion of the mouse facial prominences. PLoS ONE. 2009;4:e8066 pubmed publisher..Overall, our studies provide a valuable resource for probing orofacial development and a robust dataset for bioinformatic analysis of spatial and temporal gene expression changes during embryogenesis. ..
- Sidibe A, Mullier A, Chen P, Baroncini M, Boutin J, Delagrange P, et al. Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminence. J Pineal Res. 2010;48:263-9 pubmed publisher..is composed of three members, MT(1) and MT(2) receptors that bind melatonin with high affinity and the orphan GPR50 that does not bind melatonin but shares significant sequence homology with the two other subtypes...
- Billington C, Ng B, Forsman C, Schmidt B, Bagchi A, Symer D, et al. The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice. Dev Biol. 2011;355:21-31 pubmed publisher..We postulate that variable responses to stress may contribute to variable craniofacial phenotypes by triggering differential expression of genes and variable cellular apoptosis. ..
- Grünewald E, Tew K, Porteous D, Thomson P. Developmental expression of orphan G protein-coupled receptor 50 in the mouse brain. ACS Chem Neurosci. 2012;3:459-72 pubmed publisher..Orphan G protein-coupled receptor 50 (GPR50) has been identified as a genetic risk factor for bipolar disorder and major depression in women, and there is ..