Gene Symbol: Gpr50
Description: G-protein-coupled receptor 50
Alias: melatonin-related receptor
Species: mouse
Products:     Gpr50

Top Publications

  1. Barrett P, Ivanova E, Graham E, Ross A, Wilson D, Plé H, et al. Photoperiodic regulation of cellular retinol binding protein, CRBP1 [corrected] and nestin in tanycytes of the third ventricle ependymal layer of the Siberian hamster. J Endocrinol. 2006;191:687-98 pubmed
    ..We demonstrate that cellular retinol binding protein [corrected] (CRBP1), a retinoic acid transport protein, GPR50, an orphan G-protein-coupled receptor and nestin, an intermediate filament protein, are down-regulated in short-..
  2. Ivanova E, Bechtold D, Dupré S, Brennand J, Barrett P, Luckman S, et al. Altered metabolism in the melatonin-related receptor (GPR50) knockout mouse. Am J Physiol Endocrinol Metab. 2008;294:E176-82 pubmed
    The X-linked orphan receptor GPR50 shares 45% homology with the melatonin receptors, yet its ligand and physiological function remain unknown...
  3. Grünewald E, Kinnell H, Porteous D, Thomson P. GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth. Mol Cell Neurosci. 2009;42:363-71 pubmed publisher
    ..We sought to understand the function of one such orphan, G protein-coupled receptor 50 (GPR50), through identification of protein interactors...
  4. Bechtold D, Sidibe A, Saer B, Li J, Hand L, Ivanova E, et al. A role for the melatonin-related receptor GPR50 in leptin signaling, adaptive thermogenesis, and torpor. Curr Biol. 2012;22:70-7 pubmed publisher
    ..We show that the orphan receptor GPR50 plays an important role in adaptive thermogenesis and torpor...
  5. Wattanachanya L, Lu W, Kundu R, Wang L, Abbott M, O Carroll D, et al. Increased bone mass in mice lacking the adipokine apelin. Endocrinology. 2013;154:2069-80 pubmed publisher
    ..These results indicate that apelin functions as a physiologically significant antianabolic factor in bone in vivo. ..
  6. Salvatierra J, Lee D, Zibetti C, Duran Moreno M, Yoo S, Newman E, et al. The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation. J Neurosci. 2014;34:16809-20 pubmed publisher
    ..These findings provide key insights into the transcriptional regulatory network specifying this still poorly characterized cell type. ..
  7. Gubitz A, Reppert S. Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50). Genomics. 1999;55:248-51 pubmed
    ..Both genes were found to be X-linked: radiation hybrid mapping revealed that the human H9 gene (GPR50) is localized to Xq28...
  8. Li J, Hand L, Meng Q, Loudon A, Bechtold D. GPR50 interacts with TIP60 to modulate glucocorticoid receptor signalling. PLoS ONE. 2011;6:e23725 pubmed publisher
    b>GPR50 is an orphan G-protein coupled receptor most closely related to the melatonin receptors. The physiological function of GPR50 remains unclear, although our previous studies implicate the receptor in energy homeostasis...
  9. Batailler M, Mullier A, Sidibe A, Delagrange P, Pr vot V, Jockers R, et al. Neuroanatomical distribution of the orphan GPR50 receptor in adult sheep and rodent brains. J Neuroendocrinol. 2012;24:798-808 pubmed publisher
    b>GPR50, formerly known as melatonin-related receptor, is one of three subtypes of the melatonin receptor subfamily, together with the MT(1) and MT(2) receptors...

More Information


  1. Hand L, Saer B, Hui S, Jinnah H, Steinlechner S, Loudon A, et al. Induction of the metabolic regulator Txnip in fasting-induced and natural torpor. Endocrinology. 2013;154:2081-91 pubmed publisher
    ..We recently showed that mice lacking the orphan G protein-coupled receptor Gpr50 readily enter torpor in response to fasting and have now used these mice to conduct a microarray analysis of ..
  2. Ma Y, Wu Z, Feng Y, Xiao Z, Qin X, Ma Q. G protein coupled receptor 50 promotes self-renewal and neuronal differentiation of embryonic neural progenitor cells through regulation of notch and wnt/β-catenin signalings. Biochem Biophys Res Commun. 2015;458:836-42 pubmed publisher
    G protein-coupled receptor 50 (GPR50), a risk factor for major depressive disorder and bipolar affective disorder, is expressed in both the developmental and adult brain. However, the function of GPR50 in the brain remains unknown...
  3. Feng W, Leach S, Tipney H, Phang T, Geraci M, Spritz R, et al. Spatial and temporal analysis of gene expression during growth and fusion of the mouse facial prominences. PLoS ONE. 2009;4:e8066 pubmed publisher
    ..Overall, our studies provide a valuable resource for probing orofacial development and a robust dataset for bioinformatic analysis of spatial and temporal gene expression changes during embryogenesis. ..
  4. Sidibe A, Mullier A, Chen P, Baroncini M, Boutin J, Delagrange P, et al. Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminence. J Pineal Res. 2010;48:263-9 pubmed publisher composed of three members, MT(1) and MT(2) receptors that bind melatonin with high affinity and the orphan GPR50 that does not bind melatonin but shares significant sequence homology with the two other subtypes...
  5. Billington C, Ng B, Forsman C, Schmidt B, Bagchi A, Symer D, et al. The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice. Dev Biol. 2011;355:21-31 pubmed publisher
    ..We postulate that variable responses to stress may contribute to variable craniofacial phenotypes by triggering differential expression of genes and variable cellular apoptosis. ..
  6. Grünewald E, Tew K, Porteous D, Thomson P. Developmental expression of orphan G protein-coupled receptor 50 in the mouse brain. ACS Chem Neurosci. 2012;3:459-72 pubmed publisher
    ..Orphan G protein-coupled receptor 50 (GPR50) has been identified as a genetic risk factor for bipolar disorder and major depression in women, and there is ..