Gpr44

Summary

Gene Symbol: Gpr44
Description: G protein-coupled receptor 44
Alias: Crth2, Grp45, Ptgdr2, G-protein coupled receptor 44, PGD2 receptor, chemoattractant receptor-homologous molecule expressed on TH2 cells, prostaglandin D2 receptor 2, prostaglandin D2 receptor CRTH2
Species: mouse

Top Publications

  1. ncbi Characterization of the promoter of human CRTh2, a prostaglandin D2 receptor
    Russell Quapp
    Department of Medicine, Division of Pulmonary Medicine, Pulmonary Research Group, 574B Heritage Medical Research Centre, University of Alberta, Edmonton, AB, Canada T6G 2S2
    Biochem Biophys Res Commun 363:948-53. 2007
  2. pmc Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2
    Yoshihiro Yamamoto
    Department of Dermatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Am J Pathol 179:302-14. 2011
  3. ncbi CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice
    Rie Nomiya
    Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Immunol 180:5680-8. 2008
  4. pmc Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans
    Kang Cheng
    Department of Cardiovascular Diseases, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 103:6682-7. 2006
  5. pmc The CRTH2 agonist Pyl A prevents lipopolysaccharide-induced fetal death but induces preterm labour
    Lynne Sykes
    Department of Surgery and Cancer, Parturition Research Group, Institute of Reproduction and Developmental Biology, Imperial College London, London, UK
    Immunology 139:352-65. 2013
  6. pmc Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia
    Luis A Garza
    Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Sci Transl Med 4:126ra34. 2012
  7. pmc CRTH2 is a critical regulator of neutrophil migration and resistance to polymicrobial sepsis
    Makoto Ishii
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Immunol 188:5655-64. 2012
  8. pmc PGD2-CRTH2 pathway promotes tubulointerstitial fibrosis
    Hideyuki Ito
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Am Soc Nephrol 23:1797-809. 2012
  9. pmc Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44
    Amanda M Nelson
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Invest Dermatol 133:881-9. 2013
  10. doi Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2)
    Stefen A Boehme
    Actimis Pharmaceuticals, Inc, 10835 Road to the Cure, San Diego, CA 92121, USA
    Int Immunol 21:621-32. 2009

Scientific Experts

  • Stefen A Boehme
  • Makoto Ishii
  • Lynne Sykes
  • Hiroyuki Hirai
  • Kang Cheng
  • Rie Moroi
  • K Nagata
  • Masataka Nakamura
  • Kosuke Aritake
  • Yoshihiro Urade
  • Takahiro Satoh
  • Luis A Garza
  • Yoshihiro Yamamoto
  • Koichiro Asano
  • Shizuko Kagawa
  • Aaron N Hata
  • Hiroo Yokozeki
  • Amanda M Nelson
  • Garret A Fitzgerald
  • John A Lawson
  • Dorothy E Loy
  • Hideyuki Ito
  • Yuki Matsushima
  • M Eguchi
  • Jun Eguchi
  • Rui He
  • Yusuke Suzuki
  • Tetsuya Shiomi
  • Tsuyoshi Oguma
  • Koichi Sayama
  • M Nakamura
  • Koichi Fukunaga
  • Takahisa Murata
  • Yoshiki Shiraishi
  • Rie Nomiya
  • M Oiwa
  • Nicholas W Lukacs
  • Toshifumi Hara
  • Russell Quapp
  • Terry P Lybrand
  • Richard M Breyer
  • Eric Chevalier
  • Adiya S Katseff
  • Brinda Alagesan
  • Zaixin Yang
  • Nanae Nagata
  • Scott M Norberg
  • Masato Kubo
  • Motoaki Sano
  • Xiaoxiang Yan
  • Susan M Fischer
  • Keiichi Fukuda
  • Yoshinori Katsumata
  • Tailun Zhao
  • Yaping Liu
  • Gurpreet Ahluwalia
  • Tatsuo Hosoya
  • Tomohiro Matsuhashi
  • Hanz B Blatt
  • David C Stanton
  • Yasunori Utsunomiya
  • George Cotsarelis
  • Lee Carrasco
  • S Kariya
  • Shuh Narumiya
  • Shinobu Otani
  • Evan D Rosen
  • S Narumiya
  • Patricia C Chiu
  • T Fujiwara
  • Eleftheria Maratos-Flier
  • S Makihara
  • Jennifer L Estall
  • Tokuhiro Kimura
  • Erin E Kershaw
  • Xun Wang
  • Songtao Yu
  • Ulf Klein
  • M Okano
  • T Higaki
  • K Nishizaki
  • Joanne Dushay
  • Haoli Jin
  • James Y T Wang
  • Martin R Hodge
  • Michiko K Oyoshi
  • Raif S Geha
  • H Niwa
  • Kazunori Nishizaki
  • Gary Hardiman

Detail Information

Publications29

  1. ncbi Characterization of the promoter of human CRTh2, a prostaglandin D2 receptor
    Russell Quapp
    Department of Medicine, Division of Pulmonary Medicine, Pulmonary Research Group, 574B Heritage Medical Research Centre, University of Alberta, Edmonton, AB, Canada T6G 2S2
    Biochem Biophys Res Commun 363:948-53. 2007
    Chemoattractant-receptor homologous molecule expressed on Th2 cells (CRTh2) is a receptor for prostaglandin (PG)D2, a lipid mediator involved in allergic inflammation...
  2. pmc Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2
    Yoshihiro Yamamoto
    Department of Dermatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Am J Pathol 179:302-14. 2011
    ..effects through two distinct receptors: the chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) and the D prostanoid (DP) receptor...
  3. ncbi CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice
    Rie Nomiya
    Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Immunol 180:5680-8. 2008
    ..Two PGD(2) receptors have been isolated, DP and CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells), but whether they participate in the ..
  4. pmc Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans
    Kang Cheng
    Department of Cardiovascular Diseases, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 103:6682-7. 2006
    ..Two PGD2 receptors have been identified: PGD2 receptor 1 (DP1, also called DP) and PGD2 receptor 2 (DP2, sometimes termed CRTH2)...
  5. pmc The CRTH2 agonist Pyl A prevents lipopolysaccharide-induced fetal death but induces preterm labour
    Lynne Sykes
    Department of Surgery and Cancer, Parturition Research Group, Institute of Reproduction and Developmental Biology, Imperial College London, London, UK
    Immunology 139:352-65. 2013
    ..an agonist of the second prostaglandin D(2) receptor, chemoattractant receptor homologous to the T helper 2 cell (CRTH2)...
  6. pmc Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia
    Luis A Garza
    Department of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Sci Transl Med 4:126ra34. 2012
    ..growth inhibition requires the PGD(2) receptor G protein (heterotrimeric guanine nucleotide)-coupled receptor 44 (GPR44), but not the PGD(2) receptor 1 (PTGDR)...
  7. pmc CRTH2 is a critical regulator of neutrophil migration and resistance to polymicrobial sepsis
    Makoto Ishii
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Immunol 188:5655-64. 2012
    ..role of PGD(2) and its newly found receptor, chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), on the septic response. Severe sepsis is associated with the failure of neutrophil migration...
  8. pmc PGD2-CRTH2 pathway promotes tubulointerstitial fibrosis
    Hideyuki Ito
    Department of Cardiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Am Soc Nephrol 23:1797-809. 2012
    ..In this study, we found that L-PGDS-derived PGD(2) contributes to the progression of renal fibrosis via CRTH2-mediated activation of Th2 lymphocytes...
  9. pmc Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44
    Amanda M Nelson
    Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Invest Dermatol 133:881-9. 2013
    ..Exogenous application of PGD2 decreased WIHN in wild-type mice, and PGD2 receptor Gpr44-null mice showed increased WIHN compared with strain-matched control mice...
  10. doi Murine bone marrow-derived mast cells express chemoattractant receptor-homologous molecule expressed on T-helper class 2 cells (CRTh2)
    Stefen A Boehme
    Actimis Pharmaceuticals, Inc, 10835 Road to the Cure, San Diego, CA 92121, USA
    Int Immunol 21:621-32. 2009
    ..Both these processes were inhibited by the CRT(h)2 antagonist. These results raise the possibility that the functional consequences of the PGD(2)-CRT(h)2 interaction on mast cells may be relevant in allergic inflammation...
  11. pmc The prostaglandin D₂ receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge
    Rui He
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    J Allergy Clin Immunol 126:784-90. 2010
    ..Chemoattractant receptor-homologous molecule expressed on receptor on T(H)2 cells (CRTH2) mediates chemotaxis to PGD₂ and is expressed on T(H)2 cells and eosinophils, which infiltrate skin lesions in ..
  12. pmc Lipopolysaccharide induces proinflammatory cytokines and chemokines in experimental otitis media through the prostaglandin D2 receptor (DP)-dependent pathway
    M Eguchi
    Department of Otolaryngology Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan
    Clin Exp Immunol 163:260-9. 2011
    ..receptor (DP) and chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) are major prostaglandin D₂ receptors...
  13. pmc Transcriptional control of adipose lipid handling by IRF4
    Jun Eguchi
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Cell Metab 13:249-59. 2011
    ..Mice lacking adipocyte IRF4 exhibit increased adiposity and deficient lipolysis. These studies establish a link between IRF4 and the disposition of calories in adipose tissue, with consequences for systemic metabolic homeostasis...
  14. doi Role of prostaglandin D2 receptor CRTH2 in sustained eosinophil accumulation in the airways of mice with chronic asthma
    Shizuko Kagawa
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 155:6-11. 2011
    The prostaglandin D(2) (PGD(2))/CRTH2 pathway is important for eosinophil trafficking in vitro; however, genetic deficiency of CRTH2 does not suppress in vivo eosinophilic airway inflammation in acute models of asthma, and the role of ..
  15. doi Distinct roles of prostaglandin D2 receptors in chronic skin inflammation
    Yuki Matsushima
    Department of Dermatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8519, Tokyo, Japan
    Mol Immunol 49:304-10. 2011
    ..PGD2 exerts its effect through the CRTH2 and DP receptors...
  16. pmc Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanisms
    Stefen A Boehme
    Actimis Pharmaceuticals, Inc, 10835 Road to the Cure, San Diego, CA 92121, USA
    Int Immunol 21:1-17. 2009
    Prostaglandin D(2) (PGD(2)) and its receptor chemoattractant receptor homologous molecule expressed on T(h)2 cells (CRTH2) have been implicated in the pathogenesis of numerous allergic diseases...
  17. pmc A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation
    Stefen A Boehme
    Actimis Pharmaceuticals, Inc, 10835 Road to the Cure, San Diego, CA 92121, USA
    Int Immunol 21:81-93. 2009
    ..role that the prostaglandin D(2) receptor-chemoattractant receptor-homologous molecule expressed on T(h)2 cells (CRTH2) plays in modulating cutaneous inflammation...
  18. pmc Role of prostaglandin D2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo
    Takahisa Murata
    Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Tokyo 133 8657, Japan
    Proc Natl Acad Sci U S A 105:20009-14. 2008
    ..Our results identify PGD(2)/DP receptor as a new regulator of tumor vascular permeability, indicating DP agonism may be exploited as a potential therapy for the treatment of cancer...
  19. ncbi Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family
    H Abe
    Department of Microbiology and Immunology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Gene 227:71-7. 1999
    We have cloned the mouse CRTH2 (chemoattractant receptor-homologous molecule expressed on TH2 cells) gene encoding a putative leukocyte chemoattractant receptor, of which human homologue is expressed selectively in Th2 but not in Th1 ..
  20. ncbi Gene structure and functional properties of mouse CRTH2, a prostaglandin D2 receptor
    Hiroyuki Hirai
    Department of Advanced Medicine and Development, R and D Center, BML, Inc, Saitama 350 1101, Japan
    Biochem Biophys Res Commun 307:797-802. 2003
    b>CRTH2, the second receptor for prostaglandin D(2) (PGD(2)), is thought to play a role in allergic inflammations through the induction of chemotactic migration and/or the activation of Th2, eosinophils, and basophils, in humans...
  21. ncbi CRTH2
    K Nagata
    R and D Center, BML, Inc, Matoba, Kawagoe, Saitama, Japan
    J Biol Regul Homeost Agents 17:334-7. 2003
  22. ncbi Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2
    Aaron N Hata
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232 2372, USA
    Mol Pharmacol 67:640-7. 2005
    The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) receptor, a G protein-coupled receptor that mediates chemotaxis of inflammatory cells in response to prostaglandin D2 (PGD2), is hypothesized to play a role ..
  23. ncbi Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2
    Aaron N Hata
    Department of Pharmacology, The Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 280:32442-51. 2005
    The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a G protein-coupled receptor that mediates the pro-inflammatory effects of prostaglandin D(2) (PGD(2)) generated in allergic inflammation...
  24. ncbi Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment
    Eric Chevalier
    Department of Biology, Pfizer Global Research and Development, Fresnes, France
    J Immunol 175:2056-60. 2005
    ..recently been shown to target a novel receptor, chemoattractant receptor-homologous molecule expressed TH2 cells (CRTH2), in addition to the classic PGD (DP) receptor...
  25. ncbi Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor
    Takahiro Satoh
    Department of Dermatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Immunol 177:2621-9. 2006
    ..inflammation via specific receptors, the PGD receptor designated DP and CRTH2 (chemoattractant receptor homologous molecule expressed on Th2 cells)...
  26. ncbi Cyclooxygenase-2/prostaglandin D2/CRTH2 pathway mediates double-stranded RNA-induced enhancement of allergic airway inflammation
    Yoshiki Shiraishi
    Division of Pulmonary Medicine, Department of Medicine, Shinanomachi Research Park, Keio University School of Medicine, Tokyo, Japan
    J Immunol 180:541-9. 2008
    ..the eosinophilic inflammation in OVA-exposed animals, whereas pretreatment with a dual antagonist against the PGD2 receptor-(CRTH2) and the thromboxane A2 receptor, but not with a thromboxane A2 receptor-specific antagonist, nearly ..
  27. doi CRTH2-dependent, STAT6-independent induction of cedar pollen dermatitis
    M Oiwa
    Department of Dermatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Clin Exp Allergy 38:1357-66. 2008
    ..Airborne contact dermatitis to cedar pollen is a recently identified disease that generally affects individuals with cedar pollinosis of the nasal and/or ocular symptoms, as well as some patients with atopic dermatitis...
  28. pmc CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation
    Nicholas W Lukacs
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA
    Am J Physiol Lung Cell Mol Physiol 295:L767-79. 2008
    Prostaglandin D(2), the ligand for the G protein-coupled receptors DP1 and CRTH2, has been implicated in the pathogenesis of the allergic response in diseases such as asthma, rhinitis, and atopic dermatitis...
  29. ncbi Molecular characterization and tissue-specific expression of a murine putative G-protein-coupled receptor
    H Mayer
    Institute of Biochemistry, University of Vienna, Austria
    Biochim Biophys Acta 1399:51-6. 1998
    ..In situ hybridization studies of tissue sections revealed high expression in neurons of the brain, epithelial cells of the lung, kidney and intestine, and in alveolar macrophages...