Gene Symbol: Gpr179
Description: G protein-coupled receptor 179
Alias: 5330439C02Rik, Gpr158l1, GPR158-like 1 receptor
Species: mouse
Products:     Gpr179

Top Publications

  1. Bjarnadóttir T, Fredriksson R, Schioth H. The gene repertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptors. Gene. 2005;362:70-84 pubmed
    ..This report provides a comprehensive overview of the expansion/deletions of the groups within the Glutamate receptor family. ..
  2. Peachey N, Pearring J, Bojang P, Hirschtritt M, Sturgill Short G, Ray T, et al. Depolarizing bipolar cell dysfunction due to a Trpm1 point mutation. J Neurophysiol. 2012;108:2442-51 pubmed publisher
    ..The Trpm1(tvrm27/tvrm27) mutant will be useful for elucidating the role of TRPM1 in DBC signal transduction, for determining how Trpm1 mutations impact central visual processing, and for evaluating experimental therapies for cCSNB...
  3. Peachey N, Ray T, Florijn R, Rowe L, Sjoerdsma T, Contreras Alcantara S, et al. GPR179 is required for depolarizing bipolar cell function and is mutated in autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet. 2012;90:331-9 pubmed publisher
    ..We report here that mutations in GPR179, encoding an orphan G protein receptor, underlie a form of autosomal-recessive cCSNB...
  4. Orlandi C, Posokhova E, Masuho I, Ray T, Hasan N, Gregg R, et al. GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes. J Cell Biol. 2012;197:711-9 pubmed publisher of RGS regulators is controlled by interaction with two previously uncharacterized orphan GPCRs: GPR158 and GPR179. We show that GPR158/179 recruited RGS complexes to the plasma membrane and augmented their ability to regulate ..
  5. Ray T, Heath K, Hasan N, Noel J, SAMUELS I, Martemyanov K, et al. GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells. J Neurosci. 2014;34:6334-43 pubmed publisher
    ..In addition, another seven transmembrane protein, GPR179, is required for DBC function and recruits the regulators of G-protein signaling (RGS) proteins, RGS7 and RGS11, ..
  6. Nishiguchi K, Carvalho L, Rizzi M, Powell K, Holthaus S, Azam S, et al. Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179. Nat Commun. 2015;6:6006 pubmed publisher
    ..Here we show that a mutation in Gpr179 prevents the full restoration of vision in rd1 mice...
  7. Orlandi C, Cao Y, Martemyanov K. Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling cascade in retina ON-bipolar neurons. Invest Ophthalmol Vis Sci. 2013;54:7153-61 pubmed publisher
    ..Recently, the orphan receptor, GPR179, a member of the G protein-coupled receptor (GPCR) superfamily, has been shown to be indispensable for the ..
  8. Orhan E, Prezeau L, El Shamieh S, Bujakowska K, Michiels C, Zagar Y, et al. Further insights into GPR179: expression, localization, and associated pathogenic mechanisms leading to complete congenital stationary night blindness. Invest Ophthalmol Vis Sci. 2013;54:8041-50 pubmed publisher
    Mutations in GPR179, which encodes the G protein-coupled receptor 179, lead to autosomal recessive complete (c) congenital stationary night blindness (CSNB), which is characterized by an ON-bipolar retinal cell dysfunction...
  9. Balmer J, Ji R, Ray T, Selber F, Gassmann M, Peachey N, et al. Presence of the Gpr179(nob5) allele in a C3H-derived transgenic mouse. Mol Vis. 2013;19:2615-25 pubmed
    ..The qRT PCR experiments revealed that the nob ERG phenotype reflected a mutation in Gpr179, a gene involved in DBC signal transduction...

More Information


  1. Chang B. Survey of the nob5 mutation in C3H substrains. Mol Vis. 2015;21:1101-5 pubmed
    ..A mutation was identified in the Gpr179 gene in homozygous nob5 mice...
  2. Wang Y, Fehlhaber K, Sarria I, Cao Y, Ingram N, Guerrero Given D, et al. The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors. Neuron. 2017;93:1359-1374.e6 pubmed publisher
    ..4 function, but is not required for ribbon organization, synaptogenesis, or synaptic transmission. These findings offer insights into retinal pathologies associated with α2δ4 dysfunction. ..
  3. Klooster J, van Genderen M, Yu M, Florijn R, Riemslag F, Bergen A, et al. Ultrastructural localization of GPR179 and the impact of mutant forms on retinal function in CSNB1 patients and a mouse model. Invest Ophthalmol Vis Sci. 2013;54:6973-81 pubmed publisher
    ..Mutations in GPR179, encoding the G-protein-coupled receptor 179, have been found in CSNB1 patients...
  4. Sarria I, Orlandi C, McCall M, Gregg R, Martemyanov K. Intermolecular Interaction between Anchoring Subunits Specify Subcellular Targeting and Function of RGS Proteins in Retina ON-Bipolar Neurons. J Neurosci. 2016;36:2915-25 pubmed publisher
    ..and RGS11 that directly act on Go and two adaptor subunits: RGS Anchor Protein (R9AP) and the orphan receptor, GPR179. Here we examined the organizational principles of the GAP complex in ON-BCs...
  5. Khrimian L, Obri A, Ramos Brossier M, Rousseaud A, Moriceau S, Nicot A, et al. Gpr158 mediates osteocalcin's regulation of cognition. J Exp Med. 2017;214:2859-2873 pubmed publisher
    ..These results indicate that exogenous OCN can improve hippocampal-dependent memory in mice and identify molecular tools to harness this pathway for therapeutic purposes. ..