Gpkow

Summary

Gene Symbol: Gpkow
Description: G patch domain and KOW motifs
Alias: 4432411B18, DXErtd697e, DXImx41e, T54, G-patch domain and KOW motifs-containing protein, g patch domain and KOW motifs-containing protein, protein MOS2 homolog
Species: mouse
Products:     Gpkow

Top Publications

  1. Brunkow M, Jeffery E, Hjerrild K, Paeper B, Clark L, Yasayko S, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet. 2001;27:68-73 pubmed
    ..In sf mice, a frameshift mutation results in a product lacking the forkhead domain. Genetic complementation demonstrates that the protein product of Foxp3, scurfin, is essential for normal immune homeostasis. ..
  2. Zhang Y, Cheng Y, Bi D, Palma K, Li X. MOS2, a protein containing G-patch and KOW motifs, is essential for innate immunity in Arabidopsis thaliana. Curr Biol. 2005;15:1936-42 pubmed
    ..Our discovery on the biological functions of MOS2 will shed light on functions of the MOS2 homologs in animals, where they may also play important roles in innate immunity. ..