Gnrh1

Summary

Gene Symbol: Gnrh1
Description: gonadotropin releasing hormone 1
Alias: Gnrh, Gnrh2, LHRH, Lhrh1, Lnrh, hpg, progonadoliberin-1, gonadotropin releasing hormone 2, luteinizing hormone-releasing hormone I, progonadoliberin I
Species: mouse

Top Publications

  1. pmc Neural crest and ectodermal cells intermix in the nasal placode to give rise to GnRH-1 neurons, sensory neurons, and olfactory ensheathing cells
    Paolo Emanuele Forni
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:6915-27. 2011
  2. pmc The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer
    M E Clark
    Department of Reproductive Medicine, University of California, San Diego, La Jolla 92093 0674, USA
    Mol Cell Biol 15:6169-77. 1995
  3. doi GnRH increases glucose transporter-1 expression and stimulates glucose uptake in the gonadotroph
    Valerie M Harris
    Division of Endocrinology, Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Boulevard, 421 E Canfield, Detroit, Michigan 48201 2119, USA
    J Endocrinol 212:139-47. 2012
  4. pmc A role for FE65 in controlling GnRH-1 neurogenesis
    Paolo E Forni
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:480-91. 2011
  5. ncbi The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus
    Y Ikeda
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Endocrinol 9:478-86. 1995
  6. ncbi Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons
    Paolo Giacobini
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4156, USA
    J Neurosci 24:4737-48. 2004
  7. pmc Use of mutant mouse lines to investigate origin of gonadotropin-releasing hormone-1 neurons: lineage independent of the adenohypophysis
    Hillery Metz
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 151:766-73. 2010
  8. doi Induction of dual-specificity phosphatase 1 (DUSP1) by pulsatile gonadotropin-releasing hormone stimulation: role for gonadotropin subunit expression in mouse pituitary LbetaT2 cells
    Indri N Purwana
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Biol Reprod 84:996-1004. 2011
  9. ncbi The luteinizing hormone-releasing hormone inhibits the anti-apoptotic activity of insulin-like growth factor-1 in pituitary alphaT3 cells by protein kinase Calpha-mediated negative regulation of Akt
    Annabel Rose
    Unite de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
    J Biol Chem 279:52500-16. 2004
  10. pmc NSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expression
    Marcus Kruger
    Institute of Physiological Chemistry, University of Halle Wittenberg, Halle 06097, Germany
    EMBO J 23:4353-64. 2004

Research Grants

  1. Sex, SLE, and Signal Transduction
    Jill Jacobson; Fiscal Year: 2005
  2. The Role of Egr-1 in GnRH Neurons
    Sara DiVall; Fiscal Year: 2005
  3. Migration of early olfactory neuronal progenitors
    GERALD SCHWARTING; Fiscal Year: 2009
  4. DEVELOPMENTAL CONTROL OF GNRH EXPRESSION BY POU PROTEINS
    Margaret Wierman; Fiscal Year: 2002
  5. Differential Regulation of GnRH Gene Expression
    Helen Kim; Fiscal Year: 2005
  6. PITUITARY CELLS TO STUDY MALE INFERTILITY
    STEPHEN WINTERS; Fiscal Year: 2002
  7. Mechanisms of Response to GnRH Receptor Signaling
    MARK LAWSON; Fiscal Year: 2005
  8. Insulin Signaling in the Anterior Pituitary
    MARK LAWSON; Fiscal Year: 2006
  9. Two-photon excited fluorescence imaging of placental vasculature in vivo
    Mark Roberson; Fiscal Year: 2008
  10. NOVEL FACTORS THAT REGULATE GNRH NEURONAL DEVELOPMENT
    Margaret E Wierman; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications133 found, 100 shown here

  1. pmc Neural crest and ectodermal cells intermix in the nasal placode to give rise to GnRH-1 neurons, sensory neurons, and olfactory ensheathing cells
    Paolo Emanuele Forni
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:6915-27. 2011
    The origin of GnRH-1 cells and olfactory ensheathing cells has been controversial...
  2. pmc The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer
    M E Clark
    Department of Reproductive Medicine, University of California, San Diego, La Jolla 92093 0674, USA
    Mol Cell Biol 15:6169-77. 1995
    ..virus 40 T antigen expression by using the regulatory regions of the gene for gonadotropin-releasing hormone (GnRH), a decapeptide released from specialized neurons in the hypothalamus...
  3. doi GnRH increases glucose transporter-1 expression and stimulates glucose uptake in the gonadotroph
    Valerie M Harris
    Division of Endocrinology, Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, 3901 Beaubien Boulevard, 421 E Canfield, Detroit, Michigan 48201 2119, USA
    J Endocrinol 212:139-47. 2012
    b>GnRH is the main regulator of the hypothalamic-pituitary-gonadal (H-P-G) axis...
  4. pmc A role for FE65 in controlling GnRH-1 neurogenesis
    Paolo E Forni
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:480-91. 2011
    Gonadotropin-releasing hormone-1 (GnRH-1) neurons migrate from the nasal placode to the forebrain where they control gonadal function via the hypothalamic-pituitary-gonadal axis...
  5. ncbi The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus
    Y Ikeda
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Endocrinol 9:478-86. 1995
    ..Mice lacking SF-1 secondary to targeted disruption of the Ftz-F1 gene had normal numbers and location of GnRH neurons but exhibited grossly impaired ventromedial hypothalamic nucleus structure...
  6. ncbi Cholecystokinin modulates migration of gonadotropin-releasing hormone-1 neurons
    Paolo Giacobini
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4156, USA
    J Neurosci 24:4737-48. 2004
    ..of the brain-gut peptide cholecystokinin (CCK) in the developing olfactory-gonadotropin-releasing hormone-1 (GnRH-1) neuroendocrine systems was characterized, and the function of CCK in these systems was analyzed both in vivo and ..
  7. pmc Use of mutant mouse lines to investigate origin of gonadotropin-releasing hormone-1 neurons: lineage independent of the adenohypophysis
    Hillery Metz
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 151:766-73. 2010
    ..In this report, single- and double-mutant mice were used to examine the lineage of GnRH-1 cells...
  8. doi Induction of dual-specificity phosphatase 1 (DUSP1) by pulsatile gonadotropin-releasing hormone stimulation: role for gonadotropin subunit expression in mouse pituitary LbetaT2 cells
    Indri N Purwana
    Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Japan
    Biol Reprod 84:996-1004. 2011
    In pituitary gonadotrophs, GnRH induces expression of the mitogen-activated protein kinases (MAPK3/1) dephosphorylating enzyme, dual-specificity phosphatase 1 (DUSP1)...
  9. ncbi The luteinizing hormone-releasing hormone inhibits the anti-apoptotic activity of insulin-like growth factor-1 in pituitary alphaT3 cells by protein kinase Calpha-mediated negative regulation of Akt
    Annabel Rose
    Unite de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
    J Biol Chem 279:52500-16. 2004
    The luteinizing hormone-releasing hormone (LHRH) receptor is a G protein-coupled receptor involved in the synthesis and release of pituitary gonadotropins and in the proliferation and apoptosis of pituitary cells...
  10. pmc NSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expression
    Marcus Kruger
    Institute of Physiological Chemistry, University of Halle Wittenberg, Halle 06097, Germany
    EMBO J 23:4353-64. 2004
    To study the role of the bHLH genes NSCL-1 and NSCL-2 in the development of GnRH-1 neurons, we have generated compound mutant mice...
  11. ncbi Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse
    Yoko Toba
    Cellular and Developmental Neurobiology Section, NINDS, NIH, Bethesda, MD 20892, USA
    Eur J Neurosci 22:79-92. 2005
    Migration of gonadotropin-releasing hormone-1 (GnRH-1) neurons from the nasal placode into the central nervous system occurs in all vertebrates...
  12. ncbi The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis
    H A Ingraham
    Department of Physiology, University of California at San Francisco 94143 0556
    Genes Dev 8:2302-12. 1994
    ..These studies establish novel roles of this orphan nuclear receptor in reproductive function...
  13. ncbi The glucocorticoid receptor is tethered to DNA-bound Oct-1 at the mouse gonadotropin-releasing hormone distal negative glucocorticoid response element
    U R Chandran
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Biol Chem 274:2372-8. 1999
    An element required for glucocorticoid repression of mouse gonadotropin-releasing hormone (GnRH) gene transcription, the distal negative glucocorticoid response element (nGRE), is not bound directly by glucocorticoid receptors (GRs) but ..
  14. pmc A novel AP-1 site is critical for maximal induction of the follicle-stimulating hormone beta gene by gonadotropin-releasing hormone
    Djurdjica Coss
    Department of Reproductive Medicine, University of California, San Diego, La Jolla, California 92093 0674, USA
    J Biol Chem 279:152-62. 2004
    ..The FSHbeta subunit is primarily regulated by gonadotropin-releasing hormone (GnRH), gonadal steroids, and activin...
  15. ncbi Gonadotropin-releasing hormone (GnRH) positively regulates corticotropin-releasing hormone-binding protein expression via multiple intracellular signaling pathways and a multipartite GnRH response element in alphaT3-1 cells
    Nicole J Westphal
    University of Michigan, Neuroscience Program, Molecular and Behavioral Neuroscience Institute, Ann Arbor, Michigan 48108, USA
    Mol Endocrinol 19:2780-97. 2005
    ..To investigate the functional significance of gonadotrope CRH-BP, we examined the molecular mechanisms underlying GnRH-regulated CRH-BP expression in alphaT3-1 gonadotrope-like cells...
  16. ncbi Developmental changes in GABA receptor subunit composition within the gonadotrophin-releasing hormone-1 neuronal system
    J L Temple
    National Institute of Neurological Disorders and Stroke, Cellular and Developmental Neurobiology Section, Bethesda, MD 20892, USA
    J Neuroendocrinol 17:591-9. 2005
    ..increasingly evident that GABA plays an important role in the regulation of gonadotrophin-releasing hormone (GnRH)-1 neurones via the GABAA receptor...
  17. doi Expression and activation of N-methyl-D-aspartate receptor subunit-1 receptor subunits in gonadotrophin-releasing hormone neurones of young and middle-aged mice during the luteinising hormone surge
    V Adjan
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY 40536 0298, USA
    J Neuroendocrinol 20:1147-54. 2008
    ..Glutamate is an important excitatory neurotransmitter that stimulates the release of gonadotrophin-releasing hormone (GnRH) and participates in the generation of the luteinising hormone (LH) surge...
  18. ncbi Gonadotrophin-releasing hormone deficiency in a mutant mouse with hypogonadism
    B M Cattanach
    Nature 269:338-40. 1977
  19. ncbi Effects of FSH on Leydig cell morphology and function in the hypogonadal mouse
    P J O'Shaughnessy
    Department of Basic Sciences, Royal Veterinary College, London, U K
    J Endocrinol 135:517-25. 1992
    The hypogonadal (hpg) mouse has a congenital deficiency in gonadotrophin-releasing hormone and the gonads consequently lack exposure to endogenous gonadotrophins during development...
  20. ncbi OTX2 homeoprotein in the developing central nervous system and migratory cells of the olfactory area
    A Mallamaci
    DIBIT, Istituto Scientifico H S Raffaele, Milano, Italy
    Mech Dev 58:165-78. 1996
    ..olfactory nerve along its path from the olfactory epithelium in the nasal cavities to the olfactory bulb in rostral telencephalon and include both ensheathing glial cells and luteinizing hormone-releasing hormone (LHRH)-positive cells.
  21. ncbi Neonatal administration of FSH increases Sertoli cell numbers and spermatogenesis in gonadotropin-deficient (hpg) mice
    J Singh
    Department of Obstetrics and Gynaecology, Royal Prince Alfred Hospita, University of Sydney, New South Wales, Australia
    J Endocrinol 151:37-48. 1996
    ..alone, in the complete absence of gonadotropins, initiated qualitatively complete spermatogenesis in hypogonadal (hpg) mice...
  22. ncbi Follicle-stimulating hormone receptor mRNA in the mouse ovary during post-natal development in the normal mouse and in the adult hypogonadal (hpg) mouse: structure of alternate transcripts
    P J O'Shaughnessy
    Department of Veterinary Physiology, University of Glasgow Veterinary School, UK
    Mol Cell Endocrinol 101:197-201. 1994
    ..follicle-stimulating hormone (FSH) receptor was studied during post-natal development and in the adult hypogonadal (hpg) mouse which lacks circulating gonadotrophins...
  23. ncbi Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1- and DCC-deficient mice
    M S Deiner
    Departments of Ophthalmology and Physiology, Biomedical Sciences Program, Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Neurosci 19:9900-12. 1999
    ..Netrin protein localization also indicates that unlike in more caudal CNS, guidance about the hypothalamic ventral midline does not require midline expression of netrin...
  24. ncbi Transcription factor activator protein-2 is required for continued luteinizing hormone-releasing hormone expression in the forebrain of developing mice
    P R Kramer
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4156, USA
    Endocrinology 141:1823-38. 2000
    b>LHRH is the neuropeptide responsible for reproductive function. Prenatally, LHRH expression begins when neurons are in the olfactory pit and continues as these cells migrate into the brain...
  25. ncbi Estrogenic induction of spermatogenesis in the hypogonadal mouse
    F J Ebling
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, United Kingdom
    Endocrinology 141:2861-9. 2000
    ..in male reproductive function, by determining the effect of estradiol on testicular function in hypogonadal (hpg) mice congenitally lacking gonadotropin; and thus, sex steroid production...
  26. ncbi Midline nasal tissue influences nestin expression in nasal-placode-derived luteinizing hormone-releasing hormone neurons during development
    P R Kramer
    Cellular and Developmental Neurobiology Section, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Dev Biol 227:343-57. 2000
    Neurons differentiating into the luteinizing hormone-releasing hormone (LHRH) neuroendocrine phenotype are derived from the nasal placode...
  27. ncbi Deleted in colorectal cancer (DCC) regulates the migration of luteinizing hormone-releasing hormone neurons to the basal forebrain
    G A Schwarting
    The Shriver Center, Waltham, Massachusetts 02452, USA
    J Neurosci 21:911-9. 2001
    Luteinizing hormone-releasing hormone (LHRH) neurons migrate from the vomeronasal organ (VNO) to the forebrain in all mammals studied...
  28. ncbi Molecular and cellular properties of GnRH neurons revealed through transgenics in the mouse
    A E Herbison
    Laboratory of Neuroendocrinology, The Babraham Institute, Cambridge CB2 4AT, UK
    Mol Cell Endocrinol 185:185-94. 2001
    Recent advances in the use of gonadotropin-releasing hormone (GnRH) promoter-driven transgenics in the mouse are beginning to open up the once elusive GnRH neuronal phenotype to detailed molecular and cellular investigation...
  29. ncbi Hepatocyte growth factor/scatter factor facilitates migration of GN-11 immortalized LHRH neurons
    P Giacobini
    Department of Human and Animal Biology, University of Turin, 10123 Torino, Italy
    Endocrinology 143:3306-15. 2002
    The molecular cues regulating the migratory process of LHRH neurons from the olfactory placode into the brain are not well known, but gradients of chemotropic and chemorepellent factors secreted by the targets are likely to play a key ..
  30. ncbi Sertoli and germ cell development in hypogonadal (hpg) mice expressing transgenic follicle-stimulating hormone alone or in combination with testosterone
    Miriam Haywood
    Andrology Laboratory, ANZAC Research Institute, Concord Hospital, Concord, New South Wales 2139, Australia
    Endocrinology 144:509-17. 2003
    ..gonadal actions of FSH, distinct from LH effects, by expressing tg-FSH in gonadotropin-deficient hypogonadal (hpg) mice...
  31. pmc Gonadotrophin-releasing hormone drives melatonin receptor down-regulation in the developing pituitary gland
    Jonathan D Johnston
    School of Biological Sciences, University of Aberdeen, Aberdeen AB24 5UA, United Kingdom
    Proc Natl Acad Sci U S A 100:2831-5. 2003
    ..the transcription factor, early growth response factor-1, which is induced by gonadotrophin-releasing hormone (GnRH) and trans-activates LH beta expression, attenuated Pitx-1-induced MT(1)-luciferase activity...
  32. ncbi Origin of neuropeptide Y-containing afferents to gonadotropin-releasing hormone neurons in male mice
    Gergely F Turi
    Department of Endocrine and Behavioral Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary
    Endocrinology 144:4967-74. 2003
    The origin of neuropeptide Y (NPY) afferents to GnRH neurons was investigated in male mice...
  33. ncbi Netrin 1-mediated chemoattraction regulates the migratory pathway of LHRH neurons
    Gerald A Schwarting
    The Shriver Center, 200 Trapelo Road, Waltham, MA 02452, USA
    Eur J Neurosci 19:11-20. 2004
    Luteinizing hormone-releasing hormone (LHRH) neurons migrate from the vomeronasal organ (VNO) to the forebrain in all mammals studied...
  34. ncbi Disruption of ephrin signaling associates with disordered axophilic migration of the gonadotropin-releasing hormone neurons
    John A Gamble
    Neurobiology Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    J Neurosci 25:3142-50. 2005
    ..we have identified here a potential role for EphA5 in the axophilic migration of gonadotropin-releasing hormone (GnRH) neurons from the nasal placode into the brain along ephrin-expressing vomeronasal axons...
  35. ncbi Expression of a dominant negative FGF receptor in developing GNRH1 neurons disrupts axon outgrowth and targeting to the median eminence
    John C Gill
    Department of Integrative Physiology and the Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0354, USA
    Biol Reprod 74:463-72. 2006
    During development, neurons that synthesize and release gonadotropin-releasing hormone (GNRH1) extend their axons to the median eminence (ME) to establish neurosecretory contacts necessary for hormone secretion...
  36. ncbi Olfactory inputs to hypothalamic neurons controlling reproduction and fertility
    Hayan Yoon
    Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Cell 123:669-82. 2005
    ..we have aimed at identifying afferent pathways to neurons synthesizing luteinizing hormone-releasing hormone (LHRH, also known as gonadotropin-releasing hormone [GnRH]), a key neurohormone of reproduction...
  37. pmc Atypical development of Sertoli cells and impairment of spermatogenesis in the hypogonadal (hpg) mouse
    M Myers
    Department of Anatomy and Cell Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia
    J Anat 207:797-811. 2005
    ..hpg) mice show arrested postnatal development due to congenital deficiencies of gonadotrophin-releasing hormone (GnRH) and gonadotrophin synthesis and secretion...
  38. ncbi Stromal cell-derived factor-1 (chemokine C-X-C motif ligand 12) and chemokine C-X-C motif receptor 4 are required for migration of gonadotropin-releasing hormone neurons to the forebrain
    Gerald A Schwarting
    Shriver Center University of Massachusetts Medical Center, Waltham, Massachusetts 02452, USA
    J Neurosci 26:6834-40. 2006
    Gonadotropin-releasing hormone (GnRH) neurons migrate from the vomeronasal organ (VNO) in the nasal compartment to the basal forebrain in mice, beginning on embryonic day 11 (E11)...
  39. ncbi Lactosamine modulates the rate of migration of GnRH neurons during mouse development
    Elizabeth Bless
    Curis Inc, Cambridge, MA 02138, USA
    Eur J Neurosci 24:654-60. 2006
    Gonadotropin-releasing hormone (GnRH) neurons are derived from progenitor cells in the olfactory placodes and migrate from the vomeronasal organ (VNO) across the cribriform plate into the forebrain...
  40. ncbi Gonadotropin-releasing hormone neuron requirements for puberty, ovulation, and fertility
    Allan E Herbison
    Centre for Neuroendocrinology, Department of Physiology, University of Otago School of Medical Sciences, Dunedin, New Zealand
    Endocrinology 149:597-604. 2008
    ..The GnRH neurons of the hypothalamus represent the key cell type within the body dictating fertility...
  41. pmc Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration
    Angela Pierce
    Department of Medicine, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    Mol Endocrinol 22:2481-95. 2008
    b>GnRH neurons must undergo a complex and precise pattern of neuronal migration to appropriately target their projections to the median eminence to trigger gonadotropin secretion and thereby control reproduction...
  42. pmc Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during development
    Nichol L G Miller
    Department of Reproductive Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0674, USA
    Hum Mol Genet 18:248-60. 2009
    ..Adult mice lacking necdin have reduced numbers of gonadotropin-releasing hormone (GnRH) neurons, but the mechanism for this reduction is unknown...
  43. pmc Kisspeptin-10 facilitates a plasma membrane-driven calcium oscillator in gonadotropin-releasing hormone-1 neurons
    Stephanie Constantin
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorder and Stroke National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 150:1400-12. 2009
    Kisspeptins, the natural ligands of the G-protein-coupled receptor (GPR)-54, are the most potent stimulators of GnRH-1 secretion and as such are critical to reproductive function...
  44. pmc Semaphorin 4D regulates gonadotropin hormone-releasing hormone-1 neuronal migration through PlexinB1-Met complex
    Paolo Giacobini
    Department of Human and Animal Biology, University of Turin, Turin 10123, Italy
    J Cell Biol 183:555-66. 2008
    ..reproduction is dependent on specific neurons secreting the neuropeptide gonadotropin hormone-releasing hormone-1 (GnRH-1)...
  45. doi Anatomical location of mature GnRH neurons corresponds with their birthdate in the developing mouse
    Christine L Jasoni
    Centre for Neuroendocrinology, Department of Anatomy, University of Otago School of Medical Sciences, Dunedin, New Zealand
    Dev Dyn 238:524-31. 2009
    The gonadotropin-releasing hormone (GnRH) neurons exhibit substantial functional, anatomical, and molecular heterogeneity, which has hampered their thorough examination...
  46. pmc Otx2 induction of the gonadotropin-releasing hormone promoter is modulated by direct interactions with Grg co-repressors
    Rachel Larder
    Department of Reproductive Medicine and Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, California 92093 0674, USA
    J Biol Chem 284:16966-78. 2009
    ..In mice, gonadotropin-releasing hormone (GnRH) expression is limited to approximately 1000 neurons that originate in the olfactory placode then migrate to ..
  47. pmc Occurrence of testicular microlithiasis in androgen insensitive hypogonadal mice
    Peter J O'Shaughnessy
    Institute of Comparative Medicine, Division of Cell Sciences, University of Glasgow Veterinary School, Bearsden Rd, Glasgow G61 1QH, UK
    Reprod Biol Endocrinol 7:88. 2009
    ..Studies to identify the mechanisms of microlith development have been hampered by the lack of suitable animal models for TM...
  48. pmc DeltaNp73 regulates neuronal survival in vivo
    Fadel Tissir
    Universite Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology Unit, Brussels, Belgium
    Proc Natl Acad Sci U S A 106:16871-6. 2009
    ..In DeltaNp73(-/-) mice, cells in preoptic areas, vomeronasal neurons, GnRH-positive cells, and CRc were severely reduced in number, and choroid plexuses were atrophic...
  49. doi Hypogonadotropic hypogonadism and GNRH1 mutations in mice and humans
    Jerome Bouligand
    Université Paris Sud 11 et INSERM U693, Faculte de Medecine Paris Sud, Paris, France
    Front Horm Res 39:111-20. 2010
    ..The discovery in 1977 of a hypogonadal mouse lacking GnRH (hpg mice) and, in 1986, that the gnrh1 gene was deleted in this mouse, suggested that GNRH1 mutations might also cause human congenital idiopathic (or ..
  50. doi Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for the aetiology of hypogonadotropic hypogonadism
    Anna Cariboni
    Department of Cell and Developmental Biology, University College London, London, UK
    Hum Mol Genet 20:336-44. 2011
    ..unknown, but are thought to be due to a developmental defect in the migration of gonadotropin-releasing hormone (GnRH) neurons. Understanding the causes of the disease is hampered by lack of appropriate mouse models...
  51. pmc Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility
    Andrea Messina
    Department of Human and Animal Biology, University of Turin, Turin 10123, Italy
    Hum Mol Genet 20:4759-74. 2011
    ..in mammals is dependent on the function of specific neurons that secrete gonadotropin-releasing hormone-1 (GnRH-1)...
  52. ncbi An alternative gonadotropin-releasing hormone (GnRH) RNA splicing product found in cultured GnRH neurons and mouse hypothalamus
    S Zhen
    Department of Medicine, Division of Endocrinology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:12620-5. 1997
    Gonadotropin-releasing hormone (GnRH) is encoded by the proGnRH gene which contains four exons and three introns. In this study, two immortalized GnRH-expressing cell lines (Gn11 and NLT) were characterized...
  53. ncbi Fetal development of Leydig cell activity in the mouse is independent of pituitary gonadotroph function
    P J O'Shaughnessy
    Department of Veterinary Preclinical Sciences, University of Glasgow Veterinary School, Scotland
    Endocrinology 139:1141-6. 1998
    ..of fetal pituitary LH levels and Leydig cell function in normal mice and in hypogonadal (hpg) mice that lack GnRH and, thus, circulating gonadotropins...
  54. ncbi The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction
    M H Abel
    Department of Human Anatomy and Genetics, University of Oxford, United Kingdom
    Endocrinology 141:1795-803. 2000
    ..In the male, however, inability to respond to FSH does not impair fertility, although testicular weight is reduced, and feedback regulation of pituitary gonadotropins and intratesticular paracrine interactions may be disturbed...
  55. ncbi Promoter sequences targeting tissue-specific gene expression of hypothalamic and ovarian gonadotropin-releasing hormone in vivo
    Helen H Kim
    Section of Reproductive Endocrinology and Infertility, The Department of Obstetrics and Gynecology, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 277:5194-202. 2002
    Molecular mechanisms directing tissue-specific expression of gonadotropin-releasing hormone (GnRH) are difficult to study due to the paucity and scattered distribution of GnRH neurons...
  56. pmc Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2
    Shun ichiro Matsumoto
    Molecular Medicine Research Laboratories, Drug Discovery Research, Astellas Pharma, Inc, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
    Proc Natl Acad Sci U S A 103:4140-5. 2006
    ..Our current findings demonstrated that physiological activation of PKR2 is essential for normal development of the OB and sexual maturation...
  57. pmc Fibroblast growth factor 8 signaling through fibroblast growth factor receptor 1 is required for the emergence of gonadotropin-releasing hormone neurons
    Wilson C J Chung
    Department of Integrative Physiology and Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0354, USA
    Endocrinology 149:4997-5003. 2008
    b>GnRH neurons are essential for the onset and maintenance of reproduction...
  58. ncbi Reversal of reproductive deficiency in the hpg male mouse by neonatal androgenization
    I Livne
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029
    Biol Reprod 47:561-7. 1992
    Some aspects of reproductive function in the GnRH-deficient hypogonadal (hpg) mutant mouse can be restored by transplanting normal fetal brain tissue containing GnRH cells into the central nervous system of adult hpg mice...
  59. pmc Repression of gonadotropin-releasing hormone promoter activity by the POU homeodomain transcription factor SCIP/Oct-6/Tst-1: a regulatory mechanism of phenotype expression?
    M E Wierman
    Department of Medicine, University of Colorado Health Science Center, Denver 80220, USA
    Mol Cell Biol 17:1652-65. 1997
    ..We now report that expression of the gonadotropin-releasing hormone (GnRH) gene, which controls sexual development, is regulated by the POU protein SCIP/Oct-6/Tst-1...
  60. pmc Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons
    P R Kramer
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Genes Dev 14:1824-34. 2000
    ..Olfactory axon pathfinding is also necessary for establishment of the neuroendocrine LHRH system, cells critical for reproductive function...
  61. ncbi GnRH regulates early growth response protein 1 transcription through multiple promoter elements
    W Rachel Duan
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Mol Endocrinol 16:221-33. 2002
    Pulsatile secretion of GnRH is the major regulator of gonadotropin (LH, FSH) gene expression and secretion...
  62. ncbi Differential activation of the luteinizing hormone beta-subunit promoter by activin and gonadotropin-releasing hormone: a role for the mitogen-activated protein kinase signaling pathway in LbetaT2 gonadotrophs
    Yoko Yamada
    Department of Molecular Pharmacology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Biol Reprod 70:236-43. 2004
    ..We next examined the effects of activin A and GnRH on LHbeta promoter activity by reporter gene assay and compared the signal transduction pathways...
  63. ncbi Transplantation of the gonads of hypogonadal (hpg) mice
    S Bamber
    J Reprod Fertil 58:249-52. 1980
    Testes from hypogonadal (hpg) mice transplanted under the tunica albuginea of the testes of normal mice displayed full spermatogenic activity after 84 days...
  64. ncbi The development of astrocytes immunoreactive for glial fibrillary acidic protein in the mediobasal hypothalamus of hypogonadal mice
    J K McQueen
    Department of Pharmacology, University of Edinburgh, Scotland
    Mol Cell Neurosci 5:623-31. 1994
    ..fibrillary acidic protein (GFAP) are markedly increased in the mediobasal hypothalamus (MBH) of adult hypogonadal (hpg) mice. The astrocytosis cannot be reversed by administration of gonadal steroids...
  65. pmc NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression
    D D Belsham
    Department of Reproductive Medicine, University of California, San Diego 92093, USA
    EMBO J 15:538-47. 1996
    ..acid (NMDA), nitric oxide (NO) and cGMP each repress expression of the gonadotropin-releasing hormone (GnRH) gene in the hypothalamic cell line, GT1...
  66. ncbi Pem: a testosterone- and LH-regulated homeobox gene expressed in mouse Sertoli cells and epididymis
    J S Lindsey
    Molecular Microbiology and Immunology Graduate Program, Oregon Health Sciences University, Portland 97201, USA
    Dev Biol 179:471-84. 1996
    ..as demonstrated by a lack of expression in hypophysectomized mice, gonadotrophin-deficient hypogonadal (hpg) mutant mice, and androgen receptor-deficient (tfm) mutant mice...
  67. ncbi Expression of galanin immunoreactivity in gonadotropin-releasing hormone neurons in mice: a confocal microscopic study
    G Rajendren
    Department of Medicine, Mount Sinai School of Medicine, Box 1055, 1 Gustave L Levy Place, New York, NY 10029, USA
    Brain Res 821:270-6. 1999
    The expression of galanin immunoreactivity (galanin-IR) in gonadotropin-releasing hormone (GnRH) neurons was investigated in mice using double label immunohistochemistry combined with confocal laser scanning microscopy...
  68. ncbi Lowering cyclic adenosine-3',5'-monophosphate (cAMP) levels by expression of a cAMP-specific phosphodiesterase decreases intrinsic pulsatile gonadotropin-releasing hormone secretion from GT1 cells
    Hiroshi Yoshida
    Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California 94143, USA
    Mol Endocrinol 17:1982-90. 2003
    Pulsatile GnRH secretion is an intrinsic property of GnRH neurons...
  69. pmc Circadian gene expression regulates pulsatile gonadotropin-releasing hormone (GnRH) secretory patterns in the hypothalamic GnRH-secreting GT1-7 cell line
    Patrick E Chappell
    Department of Reproductive Medicine, University of California, San Diego, School of Medicine, La Jolla, California 92093 0674, USA
    J Neurosci 23:11202-13. 2003
    Although it has long been established that episodic secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus is required for normal gonadotropin release, the molecular and cellular mechanisms underlying the synchronous ..
  70. ncbi Gonadotropin-releasing hormone induction of extracellular-signal regulated kinase is blocked by inhibition of calmodulin
    Mark S Roberson
    Department of Biomedical Sciences, Cornell University, T3 004d Veterinary Research Tower, Ithaca, New York 14853, USA
    Mol Endocrinol 19:2412-23. 2005
    Our previous studies demonstrate that GnRH-induced ERK activation required influx of extracellular Ca2+ in alphaT3-1 and rat pituitary cells...
  71. pmc Gonadotropin-releasing hormone (GnRH) activates the m-current in GnRH neurons: an autoregulatory negative feedback mechanism?
    Chun Xu
    Department of Physiology and Pharmacology, Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    Endocrinology 149:2459-66. 2008
    b>GnRH autoregulates GnRH neurons through an ultrashort feedback loop. One potential mechanism is the regulation of K(+) channel activity through the GnRH receptor...
  72. pmc GnRH-regulated expression of Jun and JUN target genes in gonadotropes requires a functional interaction between TCF/LEF family members and beta-catenin
    Travis B Salisbury
    School of Molecular Biosciences, 639 Fulmer Hall, Washington State University 99164 4660, USA
    Mol Endocrinol 23:402-11. 2009
    b>GnRH regulates gonadotrope function through a complex transcriptional network that includes three members of the immediate early gene family: Egr1, Jun, and Atf3...
  73. doi Gonadotropin-releasing hormone inhibits ether-à-go-go-related gene K+ currents in mouse gonadotropes
    Wiebke Hirdes
    Institute for Neural Signal Transduction, Center for Molecular Neurobiology, University Hospital Hamburg Eppendorf, Falkenried 94, D 20253 Hamburg, Germany
    Endocrinology 151:1079-88. 2010
    Secretion of LH from gonadotropes is initiated by a GnRH-induced increase in intracellular Ca(2+) concentration ([Ca(2+)](i))...
  74. pmc Direct action through the sertoli cells is essential for androgen stimulation of spermatogenesis
    P J O'Shaughnessy
    Institute of Comparative Medicine, Division of Cell Sciences, University of Glasgow Veterinary School, Glasgow, UK
    Endocrinology 151:2343-8. 2010
    ..on the peritubular myoid cells alone or whether action on the Sertoli cells is essential, we crossed hypogonadal (hpg) mice that lack gonadotrophins and intratesticular androgen with mice lacking ARs either ubiquitously (ARKO) or ..
  75. pmc Netrin-1 stimulates developing GnRH neurons to extend neurites to the median eminence in a calcium- dependent manner
    Victoria F Low
    Centre for Neuroendocrinology, Department of Anatomy, University of Otago, School of Medical Sciences, Dunedin, New Zealand
    PLoS ONE 7:e46999. 2012
    Hypothalamic gonadotropin-releasing hormone (GnRH) neurons are required for fertility in all mammalian species studied to date...
  76. pmc Synchronous activation of gonadotropin-releasing hormone gene transcription and secretion by pulsatile kisspeptin stimulation
    Han Kyoung Choe
    Department of Biological Sciences, Seoul National University, Seoul 151 742, Korea
    Proc Natl Acad Sci U S A 110:5677-82. 2013
    Pulsatile release of hypothalamic gonadotropin-releasing hormone (GnRH) is essential for pituitary gonadotrope function...
  77. pmc CXC chemokine receptor 7 (CXCR7) affects the migration of GnRH neurons by regulating CXCL12 availability
    Fani Memi
    Department of Cell and Developmental Biology, University College London, WC1E 6BT, United Kingdom, Department of Pharmacology and Toxicology, University Hospital Jena, Friedrich Schiller University, 07747 Jena, Germany, and Department of Immunology, Monash University, Alfred Medical Research and Education Precinct AMREP, Melbourne, Victoria 3000, Australia
    J Neurosci 33:17527-37. 2013
    Gonadotropin-releasing hormone (GnRH) neurons are neuroendocrine cells, located in the hypothalamus, that play an essential role in mammalian reproduction...
  78. pmc The indirect role of fibroblast growth factor-8 in defining neurogenic niches of the olfactory/GnRH systems
    Paolo Emanuele Forni
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, Unit on Ocular and Stem Cell Translational Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, and Laboratory for Molecular Mechanisms of Thalamus Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama 351 0198, Japan
    J Neurosci 33:19620-34. 2013
    ..In particular, FGF8 has been implicated in specification of olfactory and gonadotropin releasing hormone-1 (GnRH) neurons, as well as in controlling olfactory stem cell survival...
  79. pmc Homer1 alternative splicing is regulated by gonadotropin-releasing hormone and modulates gonadotropin gene expression
    Qian Wang
    Center for Translational Systems Biology, Department of Neurology, and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NewYork, USA
    Mol Cell Biol 34:1747-56. 2014
    Hypothalamic gonadotropin-releasing hormone (GnRH) plays a critical role in reproductive physiology by regulating follicle-stimulating hormone (FSH) and luteinizing hormone (LH) gene expression in the pituitary...
  80. ncbi Identification of Phe313 of the gonadotropin-releasing hormone (GnRH) receptor as a site critical for the binding of nonpeptide GnRH antagonists
    J Cui
    Department of Endocrinology and Chemical Biology, Merck Research Laboratories, Rahway, New Jersey 07065, USA jisong
    Mol Endocrinol 14:671-81. 2000
    The dog GnRH receptor was cloned to facilitate the identification and characterization of selective nonpeptide GnRH antagonists. The dog receptor is 92% identical to the human GnRH receptor...
  81. ncbi Evaluation of liver fatty acid oxidation in the leptin-deficient obese mouse
    Amy E Brix
    Departments of Genomics and Pathobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Mol Genet Metab 75:219-26. 2002
    ..In summary, despite obese mice having an excess of fat available for mitochondrial beta-oxidation in liver, overall energy balance appeared to dictate that the net liver FAO remained at control levels...
  82. ncbi Molecular cloning and tissue expression of the gonadotrophin-releasing hormone receptor in the tammar wallaby (Macropus eugenii)
    Timothy C Cheung
    Developmental Biology Research Group, Research School of Biological Sciences, The Australian National University, Canberra, ACT
    Reprod Fertil Dev 14:157-64. 2002
    Gonadotrophin-releasing hormone (GnRH) plays a pivotal role in the endocrine control of both reproduction and embryonic development...
  83. ncbi Molecular cloning and characterization of a novel androgen repressible gene expressed in the prostate epithelium
    Jaskirat Singh
    Department of Medicine and Sydney Cancer Centre, Royal Prince Alfred Hospital, University of Sydney, Sydney, NSW 2006, Australia
    Gene 348:55-63. 2005
    ..We have verified that the rudimentary prostate of congenital androgen deficient mice (hpg) is indeed androgen independent...
  84. ncbi Mixed analog/digital gonadotrope biosynthetic response to gonadotropin-releasing hormone
    Frederique Ruf
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:30967-78. 2006
    Mammalian reproduction requires gonadotropin-releasing hormone (GnRH)-mediated signaling from brain neurons to pituitary gonadotropes...
  85. ncbi Genomic organization of the region spanning D14Mit262 and D14Mit86 on mouse chromosome 14 and exclusion of Adam28 and Adamdec1 as the cataract-causing gene, lr2
    E Kim
    Research Institute of Molecular Genetics, The Catholic University of Korea, Seoul, Korea
    Cytogenet Genome Res 116:12-7. 2007
    ..There was no mutation cosegregating with the phenotype of CXSD mice, which excluded these genes as the lr2 gene. Identification of more transcripts from this region and their mutation analyses are required to isolate the lr2 gene...
  86. ncbi Temporal migration of gonadotrophin-releasing hormone-1 neurones is modified in GAD67 knockout mice
    J M Lee
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, MD, USA
    J Neuroendocrinol 20:93-103. 2008
    Gonadotrophin-releasing hormone (GnRH-1) neurones reside in the forebrain and regulate gonadal function via the hypothalamic-pituitary-gonadal axis. Disruption of this axis results in reproductive dysfunction...
  87. doi Gonadotropin-releasing hormone modulates immune system function via the nuclear factor-kappaB pathway in murine Raw264.7 macrophages
    Joo Young Min
    Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea
    Neuroimmunomodulation 16:177-84. 2009
    Gonadotropin-releasing hormone (GnRH), which was originally found to be involved in the reproductive process, has also been implicated in the modulation of immune system function...
  88. pmc Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse
    Victor M Navarro
    Department of Physiology and Biophysics, University of Washington, Seattle, 98195, USA
    J Neurosci 29:11859-66. 2009
    ..In rodents, kisspeptin neurons in the arcuate nucleus (Arc) provide tonic drive to gonadotropin-releasing hormone (GnRH) neurons, which in turn supports basal luteinizing hormone (LH) secretion...
  89. pmc Reproductive dysfunction and decreased GnRH neurogenesis in a mouse model of CHARGE syndrome
    Wanda S Layman
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 5652, USA
    Hum Mol Genet 20:3138-50. 2011
    ..Expression levels of GnRH1 and Otx2 in the hypothalamus and GnRHR in the pituitary are significantly reduced in adult Chd7(Gt/+) mice...
  90. ncbi Ovarian tumors not induced by irradiation and gonadotropins in hypogonadal (hpg) mice
    B J Tennent
    Biol Reprod 34:751-60. 1986
    Hypogonadal (hpg/hpg) mice deficient in gonadotropin-releasing hormone were used to study gonadotropin involvement in ovarian tumorigenesis following gamma irradiation...
  91. ncbi Autoregulation of testicular luteinizing hormone receptors in hypogonadal (hpg/hpg) mice
    A Amador
    Biochem Genet 22:395-401. 1984
    The autoregulation of testicular luteinizing hormone (LH) receptors was studied in hypogonadal (hpg/hpg) and normal mice. The basal concentration of LH receptors was more than three-fold higher in hpg/hpg than in normal mice...
  92. ncbi Characterization of the pituitary gonadotroph cells of hypogonadal (hpg) male mice: comparison with normal mice
    I F McDowell
    J Endocrinol 95:321-30. 1982
    Hypogonadal (hpg) mice lack hypothalamic luteinizing hormone releasing hormone (LH-RH)...
  93. ncbi Development of cytochrome P-450 side chain cleavage mRNA levels in neonatal ovaries of normal and hypogonadal (hpg) mice
    P J O'Shaughnessy
    Department of Veterinary Physiology, University of Glasgow Veterinary School, UK
    Mol Cell Endocrinol 104:133-8. 1994
    ..CSCC) enzyme activity have been measured during development in the ovary of the normal mouse and the hypogonadal (hpg) mouse which lacks circulating gonadotrophins...
  94. ncbi Detection of messenger RNA for gonadotropin-releasing hormone (GnRH) but not for GnRH receptors in mouse mammary glands
    M Ikeda
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Biochem Biophys Res Commun 207:800-6. 1995
    While gonadotropin-releasing hormone (GnRH), GnRH-like, or GnRH receptor (GnRH-R) have been reported to exist in several tissues other than brain or anterior pituitary, there is no report concerning GnRH or GnRH-R gene expression in the ..
  95. ncbi A subset of peripherin positive olfactory axons delineates the luteinizing hormone releasing hormone neuronal migratory pathway in developing mouse
    S Wray
    Laboratory of Neurochemistry, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    Dev Biol 166:349-54. 1994
    Luteinizing hormone releasing hormone (LHRH) neurons in the CNS are derived from cells of the olfactory placode and thereafter migrate from the olfactory pit into the diencephalon...
  96. pmc Increased B lymphopoiesis in genetically sex steroid-deficient hypogonadal (hpg) mice
    G Smithson
    Oklahoma Medical Research Foundation, Oklahoma City 73104
    J Exp Med 180:717-20. 1994
    Interleukin 7 (IL-7) responsive B lineage precursors were greatly expanded in genetically hypogonadal female (HPG/Bm-hpg/hpg) mice that have a secondary deficiency in gonadal steroidogenesis...
  97. pmc Fine structure mapping and deletion analysis of the murine piebald locus
    D L Metallinos
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, New Jersey 08544
    Genetics 136:217-23. 1994
    ..The location of deletion breakpoints in the induced alleles, coupled with the recombination breakpoints in the backcross progeny, provide useful molecular landmarks to define the location of the piebald gene...
  98. ncbi High-resolution genetic mapping of the gunmetal gene which regulates platelet production
    E P O'Brien
    Roswell Park Cancer Institute, Molecular and Cellular Biology Department, Buffalo, New York 14263, USA
    Mamm Genome 7:206-8. 1996
  99. ncbi Suppression of gonadotropins inhibits gonadal tumorigenesis in mice transgenic for the mouse inhibin alpha-subunit promoter/simian virus 40 T-antigen fusion gene
    K Kananen
    Department of Physiology, University of Turku, Finland
    Endocrinology 138:3521-31. 1997
    ..Gonadotropin suppression was achieved either by treatment of 3-month-old mice for 2-3 months with a GnRH antagonist (Cetrorelix, SB-75), or by cross-breeding the TG mice to the genetic background of the gonadotropin-..
  100. ncbi Regulation of luteinizing hormone-receptor and follicle-stimulating hormone-receptor messenger ribonucleic acid levels during development in the neonatal mouse ovary
    P J O'Shaughnessy
    Department of Veterinary Preclinical Studies, University of Glasgow Veterinary School, United Kingdom
    Biol Reprod 57:602-8. 1997
    ..LH- and FSH-receptor mRNA levels were measured in the ovary during development in normal mice and in hypogonadal (hpg/hpg) mice, which lack circulating gonadotropins...
  101. ncbi Characterization of germ cell-specific expression of the orphan nuclear receptor, germ cell nuclear factor
    D Katz
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 138:4364-72. 1997
    ..In addition, the coding region and portions of the 3' untranslated region of the GCNF complementary DNA are conserved in the rat...

Research Grants14

  1. Sex, SLE, and Signal Transduction
    Jill Jacobson; Fiscal Year: 2005
    The hypothalamic hormone gonadotropin-releasing hormone (GnRH) displays gender-specific actions. Pituitary responsiveness to GnRH is increased in females compared to males...
  2. The Role of Egr-1 in GnRH Neurons
    Sara DiVall; Fiscal Year: 2005
    Gonadotropin releasing hormone (GnRH) is synthesized and released by neurons in the hypothalamus and is the primary neural signal regulating reproduction in mammals...
  3. Migration of early olfactory neuronal progenitors
    GERALD SCHWARTING; Fiscal Year: 2009
    The secretion of Gonadotropin-releasing hormone (GnRH, also called LHRH) is critical for regulating the pituitary-gonadal axis and ensuring reproductive competence for virtually all vertebrates...
  4. DEVELOPMENTAL CONTROL OF GNRH EXPRESSION BY POU PROTEINS
    Margaret Wierman; Fiscal Year: 2002
    ..The GnRH gene is expressed in a subset of hypothalamic neurons and is unique in its plasticity of its phenotype across ..
  5. Differential Regulation of GnRH Gene Expression
    Helen Kim; Fiscal Year: 2005
    Appropriate tissue-specific expression of gonadotropin-releasing hormone (GnRH) is critical for reproductive competence...
  6. PITUITARY CELLS TO STUDY MALE INFERTILITY
    STEPHEN WINTERS; Fiscal Year: 2002
    ..will be conducted using monolayer cultures as well as perifused pituitary cells stimulated with pulses of GnRH. The major endpoints to be examined include gonadotropin secretion and subunit gene expression, GnRH receptors and ..
  7. Mechanisms of Response to GnRH Receptor Signaling
    MARK LAWSON; Fiscal Year: 2005
    ..Isolation of actively translated and total mRNA from treated and control cells will allow identification and quantification of global changes in gene expression. ..
  8. Insulin Signaling in the Anterior Pituitary
    MARK LAWSON; Fiscal Year: 2006
    ..We will also identify the mechanism of convergent GnRH and insulin signaling...
  9. Two-photon excited fluorescence imaging of placental vasculature in vivo
    Mark Roberson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  10. NOVEL FACTORS THAT REGULATE GNRH NEURONAL DEVELOPMENT
    Margaret E Wierman; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Gonadotropin releasing hormone (GnRH) neurons originate in or near the olfactory placode and migrate into the forebrain during embryogenesis...
  11. Combinatorial Signals & Gene Expression in Trophoblasts
    Mark Roberson; Fiscal Year: 2006
    ....
  12. Modulation of Insulin Action by Testosterone in Men
    Nelly Pitteloud; Fiscal Year: 2010
    ..Therefore, if low T levels are shown to play a role in the pathogenesis of insulin resistance, T may well represent an important therapeutic modality for both preventing and treating the metabolic syndrome and type 2 diabetes in men. ..