Genomes and Genes
Gene Symbol: Gnat1
Description: guanine nucleotide binding protein, alpha transducing 1
Alias: Gnat-1, Ird1, Ird2, Tralpha, irdc, irdr, transducin, guanine nucleotide-binding protein G(t) subunit alpha-1, transducin alpha-1 chain
- Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in miceS Hattar
Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 424:76-81. 2003..Thus, the rod-cone and melanopsin systems together seem to provide all of the photic input for these accessory visual functions...
- Rods-cones and melanopsin detect light and dark to modulate sleep independent of image formationC M Altimus
Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
Proc Natl Acad Sci U S A 105:19998-20003. 2008..Thus, in addition to their known role in aligning circadian physiology with day and night, ipRGCs also relay light and dark information from both rod-cone and melanopsin-based pathways to modulate sleep and wakefulness...
- Intrinsically photosensitive retinal ganglion cells detect light with a vitamin A-based photopigment, melanopsinYingbin Fu
Departments of Neuroscience and Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205
Proc Natl Acad Sci U S A 102:10339-44. 2005..Finally, we detected no melanopsin in the RPE and no changes in rod and cone sensitivities due to melanopsin ablation. Together, these results strongly suggest that melanopsin is the photopigment in the ipRGCs...
- Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern visionJennifer L Ecker
Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
Neuron 67:49-60. 2010..Thus, nonclassical retinal photoreception occurs within diverse cell types and influences circuits and functions encompassing luminance as well as spatial information...
- Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptorsShoji Osawa
Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599 7090, USA
J Biol Chem 286:20923-9. 2011..Surprisingly, dephosphorylation was induced by light in mice missing the rod transducin α-subunit...
- Visual Arrestin 1 contributes to cone photoreceptor survival and light adaptationBruce M Brown
Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033 9224, USA
Invest Ophthalmol Vis Sci 51:2372-80. 2010....
- Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsinKatherine J Strissel
Department of Ophthalmology, Harvard Medical School, The Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
J Neurosci 26:1146-53. 2006..Thus, arrestin movement to the outer segment leads to an increase in the free arrestin concentration and thereby may serve as a powerful mechanism of light adaptation...
- Light-dependent redistribution of visual arrestins and transducin subunits in mice with defective phototransductionHoubin Zhang
Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, USA
Mol Vis 9:231-7. 2003..Upon illumination, rod and cone arrestins (Arr and cArr) translocate from the inner to the outer segments while transducin subunits (Talpha, Tbetagamma) translocate in the opposite direction...
- Photon capture and signalling by melanopsin retinal ganglion cellsMichael Tri H Do
Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nature 457:281-7. 2009..Notably, like rods, these cells are capable of signalling single-photon absorption. A flash causing a few hundred isomerized melanopsin molecules in a retina is sufficient for reaching threshold for the pupillary light reflex...
- Stable rhodopsin/arrestin complex leads to retinal degeneration in a transgenic mouse model of autosomal dominant retinitis pigmentosaJiayan Chen
Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California 90033, USA
J Neurosci 26:11929-37. 2006..to eliminate arrestin unmasked the constitutive activity of K296E and caused photoreceptor cell death through a transducin-dependent mechanism that is similar to light damage...
- The optokinetic reflex as a tool for quantitative analyses of nervous system function in mice: application to genetic and drug-induced variationHugh Cahill
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 3:e2055. 2008..These experiments show that the mouse OKR is well suited for neurologic testing in the context of drug discovery and large-scale phenotyping programs...
- Noncatalytic domains of RGS9-1.Gbeta 5L play a decisive role in establishing its substrate specificityKirill A Martemyanov
Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston Massachusetts 02114, USA
J Biol Chem 277:32843-8. 2002..regulates the duration of the cellular response to light by stimulating the GTPase activity of G protein, transducin. An important property of RGS9-1...
- Spontaneous activity of opsin apoprotein is a cause of Leber congenital amaurosisMichael L Woodruff
Department of Physiological Science, University of California Los Angeles, Los Angeles, California 90095, USA
Nat Genet 35:158-64. 2003..A genetic block of transducin signaling completely rescued degeneration irrespective of an elevated level of retinyl ester...
- Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouseMaxim Sokolov
Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
J Biol Chem 279:19149-56. 2004..function of phosducin, we tested the hypothesis that it regulates the light-driven translocation of G protein transducin from the outer segments of rod photoreceptors to other compartments of the rod cell...
- Early receptor current of wild-type and transducin knockout mice: photosensitivity and light-induced Ca2+ releaseMichael L Woodruff
Department of Physiological Science, Room 3836, Life Sciences Building, University of California Los Angeles, Los Angeles, CA 90095 1606, USA
J Physiol 557:821-8. 2004..We have also measured the ERC from rods of transducin-knockout mice, for which previous illumination to close the cGMP-gated channels was not required...
- Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunitP D Calvert
Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 97:13913-8. 2000Retinal photoreceptors use the heterotrimeric G protein transducin to couple rhodopsin to a biochemical cascade that underlies the electrical photoresponse. Several isoforms of each transducin subunit are present in the retina...
- Light regulation of retinal dopamine that is independent of melanopsin phototransductionM A Cameron
Faculty of Life Sciences, University of Manchester, Manchester, UK
Eur J Neurosci 29:761-7. 2009..Light-induced DA release was also retained in mice lacking rod phototransduction (Gnat1(-/-)), although the magnitude of this response was substantially reduced compared with wild-types, as was the ..
- A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1Grzegorz Bereta
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 285:1899-908. 2010..However, evidence is presented that autophosphorylation does not regulate GC1 activity, in contrast to phosphorylation of other members of this cyclase family...
- Transducin activation state controls its light-dependent translocation in rod photoreceptorsVasily Kerov
Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
J Biol Chem 280:41069-76. 2005Light-dependent redistribution of transducin between the rod outer segments (OS) and other photoreceptor compartments including the inner segments (IS) and synaptic terminals (ST) is recognized as a critical contributing factor to light ..
- Speed, spatial, and temporal tuning of rod and cone vision in mouseYumiko Umino
Center for Vision Research, Department of Ophthalmology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
J Neurosci 28:189-98. 2008..for optomotor responses of C57BL/6J mice with normal vision, Gnat2(cpfl3) mice without functional cones, and Gnat1-/- mice without functional rods. Gnat2(cpfl3) mice (threshold, -6...
- Functional interchangeability of rod and cone transducin alpha-subunitsWen tao Deng
Department of Ophthalmology, University of Florida, Gainesville, FL 32610, USA
Proc Natl Acad Sci U S A 106:17681-6. 2009..For example, rod and cone visual pigments couple to distinct variants of the heterotrimeric G protein transducin. However, the role of the structural differences between rod and cone transducin alpha subunits (Talpha) in ..
- Transducin translocation in rods is triggered by saturation of the GTPase-activating complexEkaterina S Lobanova
Albert Eye Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 27:1151-60. 2007Light causes massive translocation of G-protein transducin from the light-sensitive outer segment compartment of the rod photoreceptor cell...
- Evidence for two apoptotic pathways in light-induced retinal degenerationWenshan Hao
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA
Nat Genet 32:254-60. 2002..Using knockout mice with defects in rhodopsin shut-off and transducin signaling, we show that two different pathways of photoreceptor-cell apoptosis are induced by light...
- Loss of retinoschisin (RS1) cell surface protein in maturing mouse rod photoreceptors elevates the luminance threshold for light-driven translocation of transducin but not arrestinLucia Ziccardi
G B Bietti Foundation, Istituto di Ricovero e Cura a Carattere Scientifico, 00198 Rome, Italy
J Neurosci 32:13010-21. 2012..We examined light-activated transducin and arrestin translocation in young Rs1-KO mice as a marker for functional abnormalities in maturing rod ..
- Autosomal recessive retinitis pigmentosa E150K opsin mice exhibit photoreceptor disorganizationNing Zhang
Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44160, USA
J Clin Invest 123:121-37. 2013..visual cycle protein LRAT slowed retinal degeneration, whereas blocking phototransduction by crossing KK mice with GNAT1-deficient mice slightly accelerated this process...
- Defining the integration capacity of embryonic stem cell-derived photoreceptor precursorsEmma L West
Department of Genetics, UCL Institute of Ophthalmology, University College London, United Kingdom
Stem Cells 30:1424-35. 2012..Despite showing expression profiles characteristic of immature photoreceptors, the ESC-derived precursors generated using this protocol did not display transplantation competence equivalent to precursors from the postnatal retina...
- Spectral and temporal sensitivity of cone-mediated responses in mouse retinal ganglion cellsYanbin V Wang
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48105, USA
J Neurosci 31:7670-81. 2011..From recordings in mice lacking rod function (Gnat1(-/-), Rho(-/-)), we estimate ∼ 70% M-opsin expression in far dorsal retina, dropping to <5% M-opsin ..
- Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activationAmmaji Rajala
Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma73104, USA
Biochemistry 48:5563-72. 2009..These results demonstrate that Grb14 can undergo subcellular redistribution upon illumination and suggest that rhodopsin photoexcitation may trigger signaling events alternative to the classical transducin activation.
- Rod photoreceptors drive circadian photoentrainment across a wide range of light intensitiesCara M Altimus
Department of Biology, Johns Hopkins University, Baltimore, Maryland, USA
Nat Neurosci 13:1107-12. 2010..Thus, rods use two distinct retinal circuits to drive ipRGC function to support circadian photoentrainment across a wide range of light intensities...
- G-protein-coupled receptor rhodopsin regulates the phosphorylation of retinal insulin receptorAmmaji Rajala
Department of Ophthalmology, University of Oklahoma Health Science Center, Oklahoma 73104, USA
J Biol Chem 282:9865-73. 2007..We studied IR phosphorylation in mice lacking the rod-specific alpha-subunit of transducin to determine if phototransduction events are required for IR activation...
- Phosducin regulates the expression of transducin betagamma subunits in rod photoreceptors and does not contribute to phototransduction adaptationClaudia M Krispel
Center for Neuroscience and Department of Ophthamology and Vision Science, University of California, Davis, CA 95618, USA
J Gen Physiol 130:303-12. 2007For over a decade, phosducin's interaction with the betagamma subunits of the G protein, transducin, has been thought to contribute to light adaptation by dynamically controlling the amount of transducin heterotrimer available for ..
- Replacing the rod with the cone transducin subunit decreases sensitivity and accelerates response decayC K Chen
Department of Integrative Biology and Physiology, University of California Los Angeles, 3836 Life Sciences Building, Los Angeles 90095 1606, USA
J Physiol 588:3231-41. 2010..They also indicate more generally that the molecular nature of G-protein alpha may play an important role in the kinetics of G-protein cascades for metabotropic receptors throughout the body...
- The mammalian cone visual cycle promotes rapid M/L-cone pigment regeneration independently of the interphotoreceptor retinoid-binding proteinAlexander V Kolesnikov
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 31:7900-9. 2011..Thus, IRBP does not accelerate cone pigment regeneration and is not critical for the function of mouse M/L-cones in bright light...
- Retinal degeneration and failure of photoreceptor outer segment formation in mice with targeted deletion of the Joubert syndrome gene, Ahi1Jennifer E Westfall
Department of Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
J Neurosci 30:8759-68. 2010..e., transducin and Rom1) in Ahi1(-/-) mice...
- A nonsense mutation in Gnat1, encoding the alpha subunit of rod transducin, in spontaneous mouse models of retinal dysfunctionMakoto Miyamoto
Development Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 2 17 85 Jusohonmachi, Yodogawa ku, Osaka 532 8686, Japan
Exp Eye Res 90:63-9. 2010..mRNA levels of Gnat1, which encodes the alpha subunit of rod transducin (Tralpha), were severely reduced...
- Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapseRolf Herrmann
Albert Eye Research Institute, Duke University, Durham, North Carolina 27710, USA
J Neurosci 30:3239-53. 2010....
- IRD1 and IRD2 mice, naturally occurring models of hereditary retinal dysfunction, show late-onset and progressive retinal degenerationMakoto Miyamoto
Development Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Jusohonmachi 2 chome, Osaka, Japan
Curr Eye Res 35:137-45. 2010To elucidate whether Institute for Cancer Research (ICR) derived retinal dysfunction (IRD) 1 and IRD2 mice, spontaneous mouse models of rod-cone and rod dysfunction, respectively, develop age-related retinal degeneration.
- Retinol dehydrogenases (RDHs) in the visual cycleRyan O Parker
Department of Ophthalmology, Medical University of South Carolina, 167 Ashley Avenue Charleston, SC 29403, United States
Exp Eye Res 91:788-92. 2010..Here, we review the characteristics of each RDH in vitro and the findings from knockout models that suggest the roles for each in the visual cycle...
- Visual responses in mice lacking critical components of all known retinal phototransduction cascadesAnnette E Allen
Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
PLoS ONE 5:e15063. 2010..critical elements of each of these photoreceptive mechanisms via targeted disruption of genes encoding rod α transducin (Gnat1); the cone-specific α3 cyclic nucleotide gated channel subunit (Cnga3); and melanopsin (Opn4)...
- Influence of the rod photoresponse on light adaptation and circadian rhythmicity in the cone ERGMorven A Cameron
University of Manchester, Faculty of Life Sciences, Manchester, UK
Mol Vis 15:2209-16. 2009....
- Involvement of all-trans-retinal in acute light-induced retinopathy of miceAkiko Maeda
Department of Pharmacology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
J Biol Chem 284:15173-83. 2009..These findings further understanding of the mechanisms involved in light-induced retinal degeneration...
- An alternative pathway mediates the mouse and human cone visual cycleJin Shan Wang
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
Curr Biol 19:1665-9. 2009..This pigment-regeneration mechanism is essential for our daytime vision and appears to be evolutionarily conserved...
- Dissecting a role for melanopsin in behavioural light aversion reveals a response independent of conventional photoreceptionMa ayan Semo
Department of Ocular Biology and Therapeutics, University College London Institute of Ophthalmology, London, United Kingdom
PLoS ONE 5:e15009. 2010..in triple knockout (TKO) mice, lacking three elements deemed essential for conventional photoreception (Opn4(-/-) Gnat1(-/-) Cnga3(-/-))...
- Modulation of molecular interactions and function by rhodopsin palmitylationPaul S H Park
Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
Biochemistry 48:4294-304. 2009..looked at the effects of palmitylation on the chromophore-binding pocket, interactions of rhodopsin with transducin, and molecular interactions stabilizing the receptor structure...
- Bax-induced apoptosis in Leber's congenital amaurosis: a dual role in rod and cone degenerationSéverine Hamann
IRO, Institute for Research in Ophthalmology, Sion, Switzerland
PLoS ONE 4:e6616. 2009..level of anti-apoptotic Bcl-2 were restored in Rpe65(-/-)/Gnat1(-/-) mice lacking the Gnat1 gene encoding rod transducin. Moreover, photoreceptor apoptosis was prevented as assessed by TUNEL assay...
- A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducinElliott Brill
Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, Massachusetts, USA
Invest Ophthalmol Vis Sci 48:5445-53. 2007..This study examined whether three disease-associated rhodopsin substitutions Pro347Ser, Lys296Glu, and the triple mutant Val20Gly, Pro23His, Pro27Leu (VPP) caused degeneration by persistent transducin-mediated signaling activity.
- Canine rod transducin alpha-1: cloning of the cDNA and evaluation of the gene as a candidate for progressive retinal atrophyK Ray
James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
Curr Eye Res 16:71-7. 1997..The present study was undertaken to evaluate the gene for the alpha-1 subunit of the rod specific G-protein transducin (GNAT1), a member of the phototransduction pathway, as a candidate for progressive rod cone degeneration (pred) ..
- Mouse tetranectin: cDNA sequence, tissue-specific expression, and chromosomal mappingK Ibaraki
Bone Research Branch, National Institute of Dental Research National Institutes of Health NIH, Bethesda, Maryland 20892, USA
Mamm Genome 6:693-6. 1995..Finally, the genetic map location for this gene, Tna, was determined to be on distal mouse Chromosome (Chr) 9 by analysis of two sets of multilocus crosses...
- Umami taste responses are mediated by alpha-transducin and alpha-gustducinWei He
Department of Physiology and Biophysics, The Mount Sinai School of Medicine, New York, New York 10029, USA
J Neurosci 24:7674-80. 2004..We set out to determine whether alpha-gustducin also mediates umami taste and whether rod alpha-transducin (alpha(t-rod)), which is also expressed in taste receptor cells, plays a role in any of the taste responses that ..
- Bright light induces retinal degeneration by a transducin-independent mechanismElliott Brill
Tufts New England Medical Center, Boston, MA 02111, USA
Adv Exp Med Biol 533:213-9. 2003
- Identification of CRAMP, a cathelin-related antimicrobial peptide expressed in the embryonic and adult mouseR L Gallo
Joint Program in Neonatology, Children s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 272:13088-93. 1997..These data suggest that inflammatory cells in the mouse can use a nonoxidative mechanism for microbial killing and permit use of the mouse to study the role such peptides play in host defense and wound repair...
- G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathwayJacques T Weissman
ACADIA Pharmaceuticals Inc, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
Oncogene 23:241-9. 2004..A constitutively active mutant of Galphai2 also mediated Ras/rap-dependent responses. These data indicate that GPCRs coupled to pertussis-toxin-sensitive G-proteins activate Rap through a Galpha subunit, C3G, and Src-dependent pathway...
- Light-dependent translocation of arrestin in the absence of rhodopsin phosphorylation and transducin signalingAna Mendez
Zilkha Neurogenetic Institute, The Mary D Allen Laboratory for Vision Research, Beckman Macular Research Center, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089 2821, USA
J Neurosci 23:3124-9. 2003..We further show that arrestin movement is initiated by rhodopsin but does not require transducin signaling...
- Measurement of cytoplasmic calcium concentration in the rods of wild-type and transducin knock-out miceMichael L Woodruff
Department of Physiological Science, University of California, Los Angeles, CA 90095 1606, USA
J Physiol 542:843-54. 2002..Rods from transducin alpha-subunit knock-out (Tralpha-/-) animals showed no light-dependent decline in fluorescence but exhibited an ..
- Genetic mapping of the peripheral sodium channel genes, Scn9a and Scn10a, in the mouseC A Kozak
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 4, Room 329, Bethesda, Maryland 20892 0460, USA
Mamm Genome 7:787-8. 1996
- Functionally rodless mice: transgenic models for the investigation of cone function in retinal disease and therapyA L Lyubarsky
Department of Ophthalmology, F M Kirby Center for Molecular Ophthalmology, Stellar Chance Building, Room 309B, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6069, USA
Vision Res 42:401-15. 2002..without interference of rod-driven responses: (1) mice with a deletion of the gene for the rod transducin alpha-subunit (transducin alpha-/-), and (2) mice with rod arrestin deleted (arrestin -/-)...
- Fv2 encodes a truncated form of the Stk receptor tyrosine kinaseD A Persons
Department of Experimental Hematology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Nat Genet 23:159-65. 1999..We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia...
- Molecular cloning and characterization of a cDNA, CHEMR1, encoding a chemokine receptor with a homology to the human C-C chemokine receptor, CCR-4B S Youn
Department of Microbiology and Immunology, and Walther Oncology Center, Indiana University School of Medicine, Indianapolis 46202 5120, USA
Blood 89:4448-60. 1997..Our result is different from the reported properties of human CCR-4. This suggests that CHEMR1 may be a receptor for unidentified C-C chemokine or a low-affinity receptor for MIP-1alpha...
- Differential expression and interaction with the visual G-protein transducin of centrin isoforms in mammalian photoreceptor cellsAndreas Giessl
Institut fur Zoologie, Johannes Gutenberg Universitat Mainz, 55099 Mainz, Germany
J Biol Chem 279:51472-81. 2004..Massive translocation of the visual G-protein transducin, Gt, between subcellular compartments contributes to long term adaptation of photoreceptor cells...
- Visual electrophysiological features of two naturally occurring mouse models with retinal dysfunctionMakoto Miyamoto
Development Research Center, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Osaka, Japan
Curr Eye Res 31:329-35. 2006We developed two strains of mouse with retinal dysfunction, named the ICR-derived retinal dysfunction (IRD)1 and IRD2, from one male ICR mouse with a retinal dysfunction but a normal fundus...
- Assignment to mouse chromosomes of candidate genes for the rd mutationD B Farber
Jules Stein Eye Institute, UCLA School of Medicine 90024
Prog Clin Biol Res 314:143-53. 1989
- Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and humanC Blatt
Weizmann Institute, Rehovoth, Israel
Proc Natl Acad Sci U S A 85:7642-6. 1988..The retinal-specific transducin subunit genes GNAT1 and GNAT2 were on chromosomes 3 and 1; GNAI1, GNAI2, and GNAI3 were assigned to chromosomes ..
- Golf: an olfactory neuron specific-G protein involved in odorant signal transductionD T Jones
Howard Hughes Medical Institute, Department of Molecular Biology and Genetic Johns Hopkins School of Medicine, Baltimore, MD 21205
Science 244:790-5. 1989..The expression of Golf alpha in S49 cyc- kin- cells, a line deficient in endogenous stimulatory G proteins, demonstrates its capacity to stimulate adenylate cyclase in a heterologous system...
- Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factorsM A Lochrie
Science 228:96-9. 1985A bovine retinal complementary DNA clone encoding the alpha subunit of transducin (T alpha) was isolated with the use of synthetic oligodeoxynucleotides as probes, and the complete nucleotide sequence of the insert was determined...
- A critical role of CaBP4 in the cone synapseTadao Maeda
Department of Ophthalmology, University of Washington, Seattle, 98195, USA
Invest Ophthalmol Vis Sci 46:4320-7. 2005..In this study, double CaBP4/rod alpha-transducin knockout (Cabp4(-/-)Gnat1(-/-)) mice lacking the rod-mediated component of electrophysiologic responses were ..
- Regulation of prokineticin 2 expression by light and the circadian clockMichelle Y Cheng
Department of Pharmacology, University of California, Irvine, CA, USA
BMC Neurosci 6:17. 2005....
- Primary structure of the alpha-subunit of transducin and its relationship to ras proteinsT Tanabe
Nature 315:242-5. 1985..b>Transducin, a member of this protein family, mediates visual transduction by coupling the signal of photolysed rhodopsin ..
- Lentiviral gene transfer of RPE65 rescues survival and function of cones in a mouse model of Leber congenital amaurosisAlexis Pierre Bemelmans
Unit of Gene Therapy and Stem Cell Biology, Jules Gonin Eye Hospital, Lausanne, Switzerland
PLoS Med 3:e347. 2006..In the present study, we address the question of whether application of a lentiviral vector expressing the Rpe65 mouse cDNA prevents cone degeneration and restores cone function in Rpe65 knockout mice...
- The gene for the alpha-subunit of retinal rod transducin is on mouse chromosome 9M Danciger
Jules Stein Eye Institute, UCLA School of Medicine 90024 1771
Genomics 4:215-7. 1989..We have used a cDNA clone for the alpha-subunit of bovine rod transducin (T alpha 1) to map the corresponding gene, Gnat-1, to mouse chromosome 9 with a panel of Chinese hamster-mouse ..
- Ras-like genes and gene families in the mouseG Drivas
Department of Biochemistry, New York University Medical Center, New York 10016
Mamm Genome 1:112-7. 1991..Two possible clusters of Ras-like and/or G protein genes were identified, on Chrs 9 and 17...
- The Cdc25 genes map to mouse chromosomes 2, 9, and 18L F Lock
Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, P O Box B, Frederick, Maryland 21702, USA
Mamm Genome 7:771-2. 1996
- New murine polymorphisms detected by random amplified polymorphic DNA (RAPD) PCR and mapped by use of recombinant inbred strainsY C Cheah
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030
Mamm Genome 5:762-7. 1994..The 10 primers were also used to survey 20 inbred mouse strains including the progenitors of other recombinant inbred sets and four mouse strains recently inbred from the wild (CAST/Ei, MOLF/Ei, PERA/Ei, and SPRET/Ei)...
- Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein GoM Strathmann
Division of Biology, California Institute of Technology, Pasadena 91125
Proc Natl Acad Sci U S A 87:6477-81. 1990..GoA alpha transcripts are present in a variety of tissues but are most abundant in brain. The GoB alpha transcript is expressed at highest levels in brain and testis. It is possible that GoA alpha and GoB alpha have different functions...
- N-terminal fatty acylation of transducin profoundly influences its localization and the kinetics of photoresponse in rodsVasily Kerov
Department of Molecular Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
J Neurosci 27:10270-7. 2007..To examine the functional significance of N-acylation of a well understood G-protein alpha-subunit, transducin (G alpha(t)), we generated transgenic mice that expressed a mutant G alpha(t) lacking N-terminal acylation ..
- Phototransduction in a transgenic mouse model of Nougaret night blindnessMustapha Moussaif
Department of Physiology and Biophysics, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
J Neurosci 26:6863-72. 2006The Nougaret form of dominant stationary night blindness is linked to a G38D mutation in the rod transducin-alpha subunit (Talpha)...
- Novel distribution of junctional adhesion molecule-C in the neural retina and retinal pigment epitheliumLauren L Daniele
F M Kirby Center for Molecular Ophthalmology, Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Comp Neurol 505:166-76. 2007..The nonclassical distribution of Jam-C in the apical membranes of Müller cells and RPE suggests that Jam-C has a novel function in the retina...
- Mapping of the mouse macrophage inflammatory protein-1 alpha receptor gene Scya3r and two related mouse beta chemokine receptor-like genes to chromosome 9C A Kozak
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Genomics 29:294-6. 1995..Thus, like chemokine genes and alpha chemokine receptor genes, this group of beta chemokine receptor genes arose by tandem duplication...
- Redundant and unique roles of retinol dehydrogenases in the mouse retinaAkiko Maeda
Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106 4965, USA
Proc Natl Acad Sci U S A 104:19565-70. 2007..knockout (Rdh5(-/-)Rdh8(-/-)Rdh12(-/-)) mice generated on various genetic backgrounds including a rod alpha-transducin knockout to test cone function...
- Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viabilityEkaterina S Lobanova
Albert Eye Research Institute, Duke University, Durham, North Carolina 27710, USA
J Neurosci 28:3510-20. 2008b>Transducin is a prototypic heterotrimeric G-protein mediating visual signaling in vertebrate photoreceptor cells...
- Gene expression profiling of light-induced retinal degeneration in phototransduction gene knockout miceJayalakshmi Krishnan
Department of Molecular Science and Technology, Ajou University, Suwon 443 749, Korea
Exp Mol Med 40:495-504. 2008..study, mice with genetic knockout of several genes, including rhodopsin kinase (Rhok-/-), arrestin (Sag-/-), transducin (Gnat1-/-), c-Fos (c-Fos-/-) and arrestin/transducin (Sag-/-/Gnat1-/-), were examined...
- Direct rod input to cone BCs and direct cone input to rod BCs challenge the traditional view of mammalian BC circuitryJi Jie Pang
Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 107:395-400. 2010..identified depolarizing bipolar cells (DBCs) in the wild-type and three pathway-specific knockout mice (rod transducin knockout [Tralpha(-/-)], connexin36 knockout [Cx36(-/-)], and transcription factor beta4 knockout [Bhlhb4(-/-)]),..
- Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetateTadao Maeda
Department of Pharmacology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106 4965, USA
Hum Mol Genet 18:2277-87. 2009..by generating double knockout mice lacking Lrat or Rpe65 together with an inactivated rod-specific G protein transducin gene (Gnat1-/-)...
- Signal transduction of umami taste: insights from knockout miceMinqing Rong
Department of Physiology and Biophysics, Howard Hughes Medical Institute, The Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
Chem Senses 30:i33-4. 2005
- Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouseC M Eng
Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030
Genomics 9:278-82. 1991..The mapping of these members of a neurotransmitter receptor gene family may facilitate the identification of relationships between the neurotransmitter receptors and murine or human phenotypes...
- Characterization of the mouse rod transducin alpha subunit geneC J Raport
Department of Biochemistry, University of Washington, Seattle 98195
J Biol Chem 264:7122-8. 1989A genomic clone spanning the mouse rod transducin alpha subunit (Tr alpha) gene has been isolated by screening a mouse genomic library with a bovine Tr alpha cDNA clone. The coding region of the mouse Tr alpha gene reveals an 88...
- Light/dark translocation of alphatransducin in mouse photoreceptor cells expressing G90D mutant opsinZack A Nash
Cell Biology, University of Oklahoma Health Sciences Center, 940 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
Adv Exp Med Biol 572:125-31. 2006
- Partial rescue of taste responses of alpha-gustducin null mice by transgenic expression of alpha-transducinWei He
Department of Physiology and Biophysics, Howard Hughes Medical Institute, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1677, New York, NY 10029, USA
Chem Senses 27:719-27. 2002..Alpha-gustducin, a transducin-like G protein alpha-subunit, and rod alpha-transducin are expressed in taste receptor cells...
- In conditions of limited chromophore supply rods entrap 11-cis-retinal leading to loss of cone function and cell deathMarijana Samardzija
Laboratory for Retinal Cell Biology, Department of Ophthalmology, University of Zurich, Zurich, Switzerland
Hum Mol Genet 18:1266-75. 2009..These findings reinforce the notion that in patients any effective gene therapy with RPE65 needs to target the cone-rich macula directly to locally restore the cones' chromophore supply outside the reach of rods...
- Interaction of transducin-alpha with LGN, a G-protein modulator expressed in photoreceptor cellsVasiliy S Kerov
Department of Physiology and Biophysics, University of Iowa College of Medicine, BSB 5 532, Iowa City, IA 52242 1109, USA
Mol Cell Neurosci 28:485-95. 2005..that, following light-dependent translocation from the outer segments, the alpha-subunit of the visual G-protein transducin (Gtalpha) colocalizes with LGN in the basal part of the inner segments...
- Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred miceJ C Crabbe
Research Service, VA Medical Center, Portland, Oregon
J Pharmacol Exp Ther 269:184-92. 1994..abstract truncated at 250 words)..
- Intrinsic photosensitivity of retinal ganglion cellsMICHAEL TRI DO; Fiscal Year: 2007..Understanding the photosensitive ganglion cells will help in understanding basic, light-dependent physiology and its disturbance in illness. ..