glycine N methyltransferase


Gene Symbol: glycine N methyltransferase
Description: glycine N-methyltransferase
Alias: glycine N-methyltransferase, glycine N methyl transferase
Species: mouse
Products:     glycine N methyltransferase

Top Publications

  1. Liao Y, Lee T, Twu Y, Hsu S, Yang C, Wang C, et al. Glycine N-methyltransferase deficiency in female mice impairs insulin signaling and promotes gluconeogenesis by modulating the PI3K/Akt pathway in the liver. J Biomed Sci. 2016;23:69 pubmed
    ..Our data indicate that hepatic GNMT regulates lipid and glucose homeostasis, and provide insight into the development of insulin resistance through modulating the PI3K/Akt pathway. ..
  2. Gomez Santos L, Luka Z, Wagner C, Fernandez Alvarez S, Lu S, Mato J, et al. Inhibition of natural killer cells protects the liver against acute injury in the absence of glycine N-methyltransferase. Hepatology. 2012;56:747-59 pubmed publisher
  3. Wang G, Zhang J, Moskophidis D, Mivechi N. Targeted disruption of the heat shock transcription factor (hsf)-2 gene results in increased embryonic lethality, neuronal defects, and reduced spermatogenesis. Genesis. 2003;36:48-61 pubmed
    ..These findings suggest that hsf2 has a major function in controlling expression of genes important for embryonic development and maintenance of sperm production. ..
  4. Li C, Yen C, Chen Y, Lee K, Fang C, Zhang X, et al. Characterization of the GNMT-HectH9-PREX2 tripartite relationship in the pathogenesis of hepatocellular carcinoma. Int J Cancer. 2017;140:2284-2297 pubmed publisher
    ..Higher level of PREX2 in the tumor tissues was associated with poorer survival. These results reveal a novel mechanism in which GNMT participates in AKT signaling and HCC tumorigenesis by promoting HectH9-mediated PREX2 degradation. ..
  5. Liao Y, Fang C, Yen C, Hsu S, Wang C, Huang S, et al. Niemann-Pick type C2 protein regulates liver cancer progression via modulating ERK1/2 pathway: Clinicopathological correlations and therapeutical implications. Int J Cancer. 2015;137:1341-51 pubmed publisher
    ..AAV-NPC2 may thus represent a new treatment strategy for liver cancer. ..
  6. Fernández Álvarez S, Gutiérrez de Juan V, Zubiete Franco I, Barbier Torres L, Lahoz A, Parés A, et al. TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency. Lab Invest. 2015;95:223-36 pubmed publisher
  7. Yoon H, Lee D, Kim M, Bok J. Identification of genes concordantly expressed with Atoh1 during inner ear development. Anat Cell Biol. 2011;44:69-78 pubmed publisher
    ..Here, by reanalyzing archived genetic profiling data, we identified a list of novel genes possibly involved in hair cell differentiation. ..
  8. Liu S, Li Y, Lee C, Yen C, Liao Y, Huang S, et al. Higher susceptibility to aflatoxin B(1)-related hepatocellular carcinoma in glycine N-methyltransferase knockout mice. Int J Cancer. 2011;128:511-23 pubmed publisher
    ..In summary, we observed overall higher susceptibility to AFB(1)-related HCC in Gnmt-/- mice, further evidence that GNMT overexpression is an important contributing factor to liver cancer resistance...
  9. Varela Rey M, Fernandez Ramos D, Martínez López N, Embade N, Gomez Santos L, Beraza N, et al. Impaired liver regeneration in mice lacking glycine N-methyltransferase. Hepatology. 2009;50:443-52 pubmed publisher

More Information


  1. Liao Y, Liu S, Lee C, Yen C, Chuang P, Chen C, et al. Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility. Int J Cancer. 2009;124:816-26 pubmed publisher
    ..Therefore, GNMT is a tumor suppressor gene for liver cancer, and it is associated with gender disparity in liver cancer susceptibility. ..
  2. Martínez Chantar M, Vazquez Chantada M, Ariz U, Martinez N, Varela M, Luka Z, et al. Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology. 2008;47:1191-9 pubmed publisher
    ..These data demonstrate that loss of GNMT induces aberrant methylation of DNA and histones, resulting in epigenetic modulation of critical carcinogenic pathways in mice. ..
  3. Wagner C, Luka Z, Mato J. Hepatocellular carcinoma in GNMT-/- mice. Toxicol Appl Pharmacol. 2009;237:246; author reply 247 pubmed publisher
  4. Liu S, Li Y, Chen Y, Chiang E, Li A, Lee Y, et al. Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver. Hepatology. 2007;46:1413-25 pubmed
  5. Bird A, Tan K, Olsson P, Zieba M, Flecknoe S, Liddicoat D, et al. Identification of glucocorticoid-regulated genes that control cell proliferation during murine respiratory development. J Physiol. 2007;585:187-201 pubmed
    ..Amongst these processes is cell proliferation whereby GR induces expression of cell cycle repressors while suppressing induction of a well characterized cell cycle stimulator. ..
  6. Aida K, Tawata M, Negishi M, Onaya T. Mouse glycine N-methyltransferase is sexually dimorphic and regulated by growth hormone. Horm Metab Res. 1997;29:646-9 pubmed
    ..Treatment with GH of hypophysectomized male mice twice a day for 5 days decreased the expression. These results indicate that the sex difference of the mouse GNMT expression is regulated by GH secretion patterns. ..
  7. Pakhomova S, Luka Z, Grohmann S, Wagner C, Newcomer M. Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes. Proteins. 2004;57:331-7 pubmed
    ..There is an increase in kcat when going from rat to mouse to human, suggesting a correlation with the increased flexibility of some structural elements of the respective enzymes. ..
  8. Luka Z, Capdevila A, Mato J, Wagner C. A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme. Transgenic Res. 2006;15:393-7 pubmed
    ..The ratio of SAM/SAH increased from 3 in WT to 300 in livers of homozygous transgenic mice. This suggests a possible significant change in methylation in the liver and other organs where GNMT is expressed. ..
  9. Li C, Lin M, Chu S, Tu P, Fang C, Yen C, et al. Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis. Mol Med. 2015;20:684-96 pubmed publisher
    ..In summary, our findings suggest that GNMT is involved in the pathogenesis of EAE and plays a crucial role in the regulation of CD4(+) T-cell functions. ..
  10. Carrasco M, Rabaneda L, Murillo Carretero M, Ortega Martinez S, Martinez Chantar M, Woodhoo A, et al. Glycine N-methyltransferase expression in the hippocampus and its role in neurogenesis and cognitive performance. Hippocampus. 2014;24:840-52 pubmed publisher
    ..These results suggest that alterations in the concentration of SAMe impair neurogenesis and contribute to cognitive decline. ..
  11. Varela Rey M, Iruarrizaga Lejarreta M, Lozano J, Aransay A, Fernandez A, Lavín J, et al. S-adenosylmethionine levels regulate the schwann cell DNA methylome. Neuron. 2014;81:1024-1039 pubmed publisher
  12. Chou W, Zhao J, Chen Y, Lee K, Su K, Shyue S, et al. Role of glycine N-methyltransferase in experimental ulcerative colitis. J Gastroenterol Hepatol. 2014;29:494-501 pubmed publisher
    ..Collectively, our findings suggest that GNMT may be a crucial molecule in the pathogenesis of DSS-induced colitis. This finding may provide new information for a potential therapeutic target in treating IBD. ..
  13. Wang Y, Lin W, Lin Y, Tang F, Chen Y, Chiang E. A novel role of the tumor suppressor GNMT in cellular defense against DNA damage. Int J Cancer. 2014;134:799-810 pubmed publisher
    ..The present study gives new insights into the underlying mechanism by which GNMT can participate in tumor prevention/suppression in humans...
  14. Martínez Uña M, Varela Rey M, Cano A, Fernández Ares L, Beraza N, Aurrekoetxea I, et al. Excess S-adenosylmethionine reroutes phosphatidylethanolamine towards phosphatidylcholine and triglyceride synthesis. Hepatology. 2013;58:1296-305 pubmed publisher
    ..These findings indicate that excess SAMe reroutes PE towards PC and TG synthesis and lipid sequestration. ..
  15. Martínez López N, García Rodríguez J, Varela Rey M, Gutiérrez V, Fernández Ramos D, Beraza N, et al. Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1. Gastroenterology. 2012;143:787-798.e13 pubmed publisher
    ..Reagents that disrupt this pathway might be developed to treat patients with HCC. ..
  16. Yang C, Wang H, Tsai T, Fan A, Hsu C, Chen C, et al. Characterization of the neuropsychological phenotype of glycine N-methyltransferase-/- mice and evaluation of its responses to clozapine and sarcosine treatments. Eur Neuropsychopharmacol. 2012;22:596-606 pubmed publisher
    ..GNMT plays an important role in maintaining normal physiological function of brain and Tg-GNMT/Gnmt-/- mice are useful models for development of therapeutics for patients with schizophrenia. ..
  17. Liao Y, Chen T, Lee T, Wang H, Wang C, Liao L, et al. Glycine N-methyltransferase deficiency affects Niemann-Pick type C2 protein stability and regulates hepatic cholesterol homeostasis. Mol Med. 2012;18:412-22 pubmed publisher
    ..Novel therapeutics for steatohepatitis and HCC may be developed by using this concept. ..