Gjb6

Summary

Gene Symbol: Gjb6
Description: gap junction protein, beta 6
Alias: AA958971, Cx30, D14Bwg0506e, gap junction beta-6 protein, connexin-30, gap junction membrane channel protein beta 6
Species: mouse
Products:     Gjb6

Top Publications

  1. Cohen Salmon M, Regnault B, Cayet N, Caille D, Demuth K, Hardelin J, et al. Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis. Proc Natl Acad Sci U S A. 2007;104:6229-34 pubmed
    ..The absence of the gap junction protein connexin30 (Cx30) in Cx30(-/-) mice results in the SV failure to produce an EP, which mainly accounts for the severe congenital ..
  2. Sun Y, Tang W, Chang Q, Wang Y, Kong W, Lin X. Connexin30 null and conditional connexin26 null mice display distinct pattern and time course of cellular degeneration in the cochlea. J Comp Neurol. 2009;516:569-79 pubmed publisher
    Mutations in connexin26 (Cx26) and Cx30 are the most common cause of nonsyndromic inherited deafness in humans...
  3. Ahmad S, Tang W, Chang Q, Qu Y, Hibshman J, Li Y, et al. Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafness. Proc Natl Acad Sci U S A. 2007;104:1337-41 pubmed
    Mutations in genes coding for connexin26 (Cx26) and/or Cx30 are linked to approximately half of all cases of human autosomal nonsyndromic prelingual deafness...
  4. Rouach N, Koulakoff A, Abudara V, Willecke K, Giaume C. Astroglial metabolic networks sustain hippocampal synaptic transmission. Science. 2008;322:1551-5 pubmed publisher
    ..These results indicate that astroglial gap junctions provide an activity-dependent intercellular pathway for the delivery of energetic metabolites from blood vessels to distal neurons. ..
  5. Gosejacob D, Dublin P, Bedner P, Hüttmann K, Zhang J, Tress O, et al. Role of astroglial connexin30 in hippocampal gap junction coupling. Glia. 2011;59:511-9 pubmed publisher
    The impact of connexin30 (Cx30) on interastrocytic gap junction coupling in the normal hippocampus is matter of debate; reporter gene analyses indicated a weak expression of Cx30 in the mouse hippocampus...
  6. Pannasch U, Vargova L, Reingruber J, Ezan P, Holcman D, Giaume C, et al. Astroglial networks scale synaptic activity and plasticity. Proc Natl Acad Sci U S A. 2011;108:8467-72 pubmed publisher
    ..Although the gap junction proteins connexin 30 (Cx30) and connexin 43 (Cx43) mediate the extensive network organization of astrocytes, their role in synaptic ..
  7. Ahmad S, Chen S, Sun J, Lin X. Connexins 26 and 30 are co-assembled to form gap junctions in the cochlea of mice. Biochem Biophys Res Commun. 2003;307:362-8 pubmed
    ..Two of these connexins (Cx26 and Cx30), both belonging to the beta-group, were investigated for their molecular assemblies in the cochlea...
  8. Teubner B, Michel V, Pesch J, Lautermann J, Cohen Salmon M, Sohl G, et al. Connexin30 (Gjb6)-deficiency causes severe hearing impairment and lack of endocochlear potential. Hum Mol Genet. 2003;12:13-21 pubmed
    The gap junction protein connexin30 (Cx30) is expressed in a variety of tissues that include epithelial and mesenchymal structures of the inner ear. We generated Cx30 (Gjb6) deficient mice by deletion of the Cx30 coding region...
  9. Requardt R, Kaczmarczyk L, Dublin P, Wallraff Beck A, Mikeska T, Degen J, et al. Quality control of astrocyte-directed Cre transgenic mice: the benefits of a direct link between loss of gene expression and reporter activation. Glia. 2009;57:680-92 pubmed publisher
    ..We present several strategies to control for the fidelity of hGFAP-Cre mediated recombination. (c) 2008 Wiley-Liss, Inc. ..
  10. Forge A, Becker D, Casalotti S, Edwards J, Marziano N, Nevill G. Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals. J Comp Neurol. 2003;467:207-31 pubmed
    ..mammalian inner ear by RT-PCR, Western blotting, and immunohistochemistry revealed four connexin isotypes, cx26, cx30, cx31, and cx43, in the cochlea and three, cx26, cx30, and cx43, in the vestibular organs...

Detail Information

Publications78

  1. Cohen Salmon M, Regnault B, Cayet N, Caille D, Demuth K, Hardelin J, et al. Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis. Proc Natl Acad Sci U S A. 2007;104:6229-34 pubmed
    ..The absence of the gap junction protein connexin30 (Cx30) in Cx30(-/-) mice results in the SV failure to produce an EP, which mainly accounts for the severe congenital ..
  2. Sun Y, Tang W, Chang Q, Wang Y, Kong W, Lin X. Connexin30 null and conditional connexin26 null mice display distinct pattern and time course of cellular degeneration in the cochlea. J Comp Neurol. 2009;516:569-79 pubmed publisher
    Mutations in connexin26 (Cx26) and Cx30 are the most common cause of nonsyndromic inherited deafness in humans...
  3. Ahmad S, Tang W, Chang Q, Qu Y, Hibshman J, Li Y, et al. Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafness. Proc Natl Acad Sci U S A. 2007;104:1337-41 pubmed
    Mutations in genes coding for connexin26 (Cx26) and/or Cx30 are linked to approximately half of all cases of human autosomal nonsyndromic prelingual deafness...
  4. Rouach N, Koulakoff A, Abudara V, Willecke K, Giaume C. Astroglial metabolic networks sustain hippocampal synaptic transmission. Science. 2008;322:1551-5 pubmed publisher
    ..These results indicate that astroglial gap junctions provide an activity-dependent intercellular pathway for the delivery of energetic metabolites from blood vessels to distal neurons. ..
  5. Gosejacob D, Dublin P, Bedner P, Hüttmann K, Zhang J, Tress O, et al. Role of astroglial connexin30 in hippocampal gap junction coupling. Glia. 2011;59:511-9 pubmed publisher
    The impact of connexin30 (Cx30) on interastrocytic gap junction coupling in the normal hippocampus is matter of debate; reporter gene analyses indicated a weak expression of Cx30 in the mouse hippocampus...
  6. Pannasch U, Vargova L, Reingruber J, Ezan P, Holcman D, Giaume C, et al. Astroglial networks scale synaptic activity and plasticity. Proc Natl Acad Sci U S A. 2011;108:8467-72 pubmed publisher
    ..Although the gap junction proteins connexin 30 (Cx30) and connexin 43 (Cx43) mediate the extensive network organization of astrocytes, their role in synaptic ..
  7. Ahmad S, Chen S, Sun J, Lin X. Connexins 26 and 30 are co-assembled to form gap junctions in the cochlea of mice. Biochem Biophys Res Commun. 2003;307:362-8 pubmed
    ..Two of these connexins (Cx26 and Cx30), both belonging to the beta-group, were investigated for their molecular assemblies in the cochlea...
  8. Teubner B, Michel V, Pesch J, Lautermann J, Cohen Salmon M, Sohl G, et al. Connexin30 (Gjb6)-deficiency causes severe hearing impairment and lack of endocochlear potential. Hum Mol Genet. 2003;12:13-21 pubmed
    The gap junction protein connexin30 (Cx30) is expressed in a variety of tissues that include epithelial and mesenchymal structures of the inner ear. We generated Cx30 (Gjb6) deficient mice by deletion of the Cx30 coding region...
  9. Requardt R, Kaczmarczyk L, Dublin P, Wallraff Beck A, Mikeska T, Degen J, et al. Quality control of astrocyte-directed Cre transgenic mice: the benefits of a direct link between loss of gene expression and reporter activation. Glia. 2009;57:680-92 pubmed publisher
    ..We present several strategies to control for the fidelity of hGFAP-Cre mediated recombination. (c) 2008 Wiley-Liss, Inc. ..
  10. Forge A, Becker D, Casalotti S, Edwards J, Marziano N, Nevill G. Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammals. J Comp Neurol. 2003;467:207-31 pubmed
    ..mammalian inner ear by RT-PCR, Western blotting, and immunohistochemistry revealed four connexin isotypes, cx26, cx30, cx31, and cx43, in the cochlea and three, cx26, cx30, and cx43, in the vestibular organs...
  11. Kunze A, Congreso M, Hartmann C, Wallraff Beck A, Hüttmann K, Bedner P, et al. Connexin expression by radial glia-like cells is required for neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2009;106:11336-41 pubmed publisher
    ..Neuronal precursors were not coupled. Mice lacking Cx30 and Cx43 in GFAP-positive cells displayed almost complete inhibition of proliferation and a significant decline in ..
  12. Sun J, Ahmad S, Chen S, Tang W, Zhang Y, Chen P, et al. Cochlear gap junctions coassembled from Cx26 and 30 show faster intercellular Ca2+ signaling than homomeric counterparts. Am J Physiol Cell Physiol. 2005;288:C613-23 pubmed
    ..However, it is still unclear how Cxs contribute to the cochlear function. Recent data (33) obtained from Cx30 knockout mice showing that a reduction of Cx diversity in assembling gap junctions is sufficient to cause deafness ..
  13. Zhang Y, Tang W, Ahmad S, Sipp J, Chen P, Lin X. Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functions. Proc Natl Acad Sci U S A. 2005;102:15201-6 pubmed
    Dysfunction of gap junctions (GJs) caused by mutations in connexin26 (Cx26) and Cx30 accounts for nearly half of all cases of hereditary nonsyndromic deafness cases...
  14. Ortolano S, Di Pasquale G, Crispino G, Anselmi F, Mammano F, Chiorini J. Coordinated control of connexin 26 and connexin 30 at the regulatory and functional level in the inner ear. Proc Natl Acad Sci U S A. 2008;105:18776-81 pubmed publisher
    Connexin 26 (Cx26) and connexin 30 (Cx30) are encoded by two genes (GJB2 and GJB6, respectively) that are found within 50 kb in the same complex deafness locus, DFNB1...
  15. Wallraff A, Köhling R, Heinemann U, Theis M, Willecke K, Steinhäuser C. The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus. J Neurosci. 2006;26:5438-47 pubmed
    ..In general, a surprisingly large capacity for K+ clearance was conserved in mice with coupling-deficient astrocytes, indicating that gap junction-dependent processes only partially account for K+ buffering in the hippocampus. ..
  16. Anselmi F, Hernandez V, Crispino G, Seydel A, Ortolano S, Roper S, et al. ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear. Proc Natl Acad Sci U S A. 2008;105:18770-5 pubmed publisher
    ..By contrast, Ca(2+) responses failed to propagate in cultures with defective expression of connexin 26 (Cx26) or Cx30. A companion paper demonstrates that, if expression of either Cx26 or Cx30 is blocked, expression of the other is ..
  17. Pannasch U, Freche D, Dallérac G, Ghezali G, Escartin C, Ezan P, et al. Connexin 30 sets synaptic strength by controlling astroglial synapse invasion. Nat Neurosci. 2014;17:549-58 pubmed publisher
    Astrocytes play active roles in brain physiology by dynamic interactions with neurons. Connexin 30, one of the two main astroglial gap-junction subunits, is thought to be involved in behavioral and basic cognitive processes...
  18. Qu Y, Tang W, Dahlke I, Ding D, Salvi R, Sohl G, et al. Analysis of connexin subunits required for the survival of vestibular hair cells. J Comp Neurol. 2007;504:499-507 pubmed
    ..The most commonly found human Cx mutations are either Cx26 or Cx30 deletions...
  19. Ghézali G, Calvo C, Pillet L, Llense F, Ezan P, Pannasch U, et al. Connexin 30 controls astroglial polarization during postnatal brain development. Development. 2018;145: pubmed publisher
    ..b>Connexin 30, an astroglial gap-junction channel-forming protein expressed postnatally, regulates in situ the ..
  20. Langer J, Stephan J, Theis M, Rose C. Gap junctions mediate intercellular spread of sodium between hippocampal astrocytes in situ. Glia. 2012;60:239-52 pubmed publisher
    ..was disturbed on pharmacological inhibition of gap junctions, reduced in animals at P4 and virtually omitted in Cx30/Cx43 double-deficient mice...
  21. Nagy J, Patel D, Ochalski P, Stelmack G. Connexin30 in rodent, cat and human brain: selective expression in gray matter astrocytes, co-localization with connexin43 at gap junctions and late developmental appearance. Neuroscience. 1999;88:447-68 pubmed
    ..Taken together, these results suggest that astrocytic connexin30 expression at both regional and cellular levels is subject to regulation in adult brain as well as during brain development. ..
  22. Torres A, Wang F, Xu Q, Fujita T, Dobrowolski R, Willecke K, et al. Extracellular Ca²? acts as a mediator of communication from neurons to glia. Sci Signal. 2012;5:ra8 pubmed publisher
    ..Thus, astrocytic ATP release evoked by an activity-associated decrease in [Ca(2+)](e) may provide a negative feedback mechanism that potentiates inhibitory transmission in response to local hyperexcitability. ..
  23. Kretz M, Euwens C, Hombach S, Eckardt D, Teubner B, Traub O, et al. Altered connexin expression and wound healing in the epidermis of connexin-deficient mice. J Cell Sci. 2003;116:3443-52 pubmed
    ..These results suggest that downregulation of connexin43 appears to be a prerequisite for the coordinated proliferation and mobilization of keratinocytes during wound healing. ..
  24. Alstrøm J, Hansen D, Nielsen M, MacAulay N. Isoform-specific phosphorylation-dependent regulation of connexin hemichannels. J Neurophysiol. 2015;114:3014-22 pubmed publisher
    ..Connexin (Cx)43 and Cx30 are the major astrocytic connexins...
  25. Dere E, De Souza Silva M, Frisch C, Teubner B, Sohl G, Willecke K, et al. Connexin30-deficient mice show increased emotionality and decreased rearing activity in the open-field along with neurochemical changes. Eur J Neurosci. 2003;18:629-38 pubmed
    ..Thus, we have tested groups of Cx30-/-, Cx30+/-, and Cx30+/+ mice in the open-field, an object exploration task, in the graded anxiety test and on the ..
  26. Schütz M, Scimemi P, Majumder P, De Siati R, Crispino G, Rodriguez L, et al. The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice. Hum Mol Genet. 2010;19:4759-73 pubmed publisher
    Mutations in the GJB2 and GJB6 genes, respectively, coding for connexin26 (Cx26) and connexin30 (Cx30) proteins, are the most common cause for prelingual non-syndromic deafness in humans...
  27. Schnichels M, Wörsdörfer P, Dobrowolski R, Markopoulos C, Kretz M, Schwarz G, et al. The connexin31 F137L mutant mouse as a model for the human skin disease erythrokeratodermia variabilis (EKV). Hum Mol Genet. 2007;16:1216-24 pubmed
    ..So far, several mutations in the Cx31 or Cx30.3 gene have been reported to cause EKV in humans...
  28. Tress O, Maglione M, May D, Pivneva T, Richter N, Seyfarth J, et al. Panglial gap junctional communication is essential for maintenance of myelin in the CNS. J Neurosci. 2012;32:7499-518 pubmed publisher
    In this study, we have investigated the contribution of oligodendrocytic connexin47 (Cx47) and astrocytic Cx30 to panglial gap junctional networks as well as myelin maintenance and function by deletion of both connexin coding DNAs in mice...
  29. Sibille J, Pannasch U, Rouach N. Astroglial potassium clearance contributes to short-term plasticity of synaptically evoked currents at the tripartite synapse. J Physiol. 2014;592:87-102 pubmed publisher
    ..These results show that astrocytes integrate synaptic activity via multiple ionic channels and transporters and contribute to short-term plasticity in part via potassium clearance mediated by Kir4.1 channels. ..
  30. Mei L, Chen J, Zong L, Zhu Y, Liang C, Jones R, et al. A deafness mechanism of digenic Cx26 (GJB2) and Cx30 (GJB6) mutations: Reduction of endocochlear potential by impairment of heterogeneous gap junctional function in the cochlear lateral wall. Neurobiol Dis. 2017;108:195-203 pubmed publisher
    Digenic Connexin26 (Cx26, GJB2) and Cx30 (GJB6) heterozygous mutations are the second most frequent cause of recessive deafness in humans. However, the underlying deafness mechanism remains unclear...
  31. Griemsmann S, Höft S, Bedner P, Zhang J, von Staden E, Beinhauer A, et al. Characterization of Panglial Gap Junction Networks in the Thalamus, Neocortex, and Hippocampus Reveals a Unique Population of Glial Cells. Cereb Cortex. 2015;25:3420-33 pubmed publisher
    ..Cxs), semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) and western blotting showed that Cx30 is the dominant astrocytic Cx in the thalamus...
  32. Zorzi V, Paciello F, Ziraldo G, Peres C, Mazzarda F, Nardin C, et al. Mouse Panx1 Is Dispensable for Hearing Acquisition and Auditory Function. Front Mol Neurosci. 2017;10:379 pubmed publisher
    ..Therefore, our results provide strong evidence that, in mice, Panx1 is dispensable for hearing acquisition and auditory function. ..
  33. Fujimoto A, Kurban M, Nakamura M, Farooq M, Fujikawa H, Kibbi A, et al. GJB6, of which mutations underlie Clouston syndrome, is a potential direct target gene of p63. J Dermatol Sci. 2013;69:159-66 pubmed publisher
    ..The disease is caused by mutations in GJB6 gene, which encodes a gap junction protein connexin 30 (Cx30)...
  34. Abudara V, Roux L, Dallérac G, Matias I, Dulong J, Mothet J, et al. Activated microglia impairs neuroglial interaction by opening Cx43 hemichannels in hippocampal astrocytes. Glia. 2015;63:795-811 pubmed publisher
    ..As a whole our findings point out astroglial hemichannels as key determinants of the impairment of synaptic transmission during neuroinflammation. ..
  35. Sohl G, Willecke K. An update on connexin genes and their nomenclature in mouse and man. Cell Commun Adhes. 2003;10:173-80 pubmed
    ..Furthermore, this short review contains an update on phenotypic correlations between connexin deficient mice and patients bearing mutations in their orthologous connexin genes. ..
  36. Plante I, Wallis A, Shao Q, Laird D. Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged. Biol Reprod. 2010;82:837-47 pubmed publisher
    ..Surprisingly, the levels and/or localization of Cx26 (Gjb2), Cx30 (Gjb6), Cx32 (Gjb1), E-cadherin, P-cadherin, beta-catenin, claudin-1, and occludin were all unaffected by the ..
  37. del Castillo F, Cohen Salmon M, Charollais A, Caille D, Lampe P, Chavrier P, et al. Consortin, a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins. Hum Mol Genet. 2010;19:262-75 pubmed publisher
    ..Sequence accession numbers. GenBank: Human CNST cDNA, NM_152609; mouse Cnst cDNA, NM_146105. ..
  38. Chen J, Zhu Y, Liang C, Chen J, Zhao H. Pannexin1 channels dominate ATP release in the cochlea ensuring endocochlear potential and auditory receptor potential generation and hearing. Sci Rep. 2015;5:10762 pubmed publisher
    ..Moreover, defect of connexin hemichannels by deletion of connexin26 (Cx26) and Cx30, which are predominant connexin isoforms in the cochlea, did not reduce ATP release under physiological conditions...
  39. Buniello A, Montanaro D, Volinia S, Gasparini P, Marigo V. An expression atlas of connexin genes in the mouse. Genomics. 2004;83:812-20 pubmed
  40. Liebmann M, Stahr A, Guenther M, Witte O, Frahm C. Astrocytic Cx43 and Cx30 differentially modulate adult neurogenesis in mice. Neurosci Lett. 2013;545:40-5 pubmed publisher
    ..The aim of this study was to determine whether loss of the main astrocytic connexins, connexin 43 (Cx43) or connexin 30 (Cx30), influences various stages of adult hippocampal neurogenesis...
  41. Forge A, Jagger D, Kelly J, Taylor R. Connexin30-mediated intercellular communication plays an essential role in epithelial repair in the cochlea. J Cell Sci. 2013;126:1703-12 pubmed publisher
    ..Gap junctions in which Cx30 is the predominant connexin are large and numerous between supporting cells...
  42. Penes M, Li X, Nagy J. Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain. Eur J Neurosci. 2005;22:404-18 pubmed
    ..with astrocytic connexins by confocal immunofluorescence demonstration of ZO-1 colocalization with astrocytic Cx30 and Cx43, and by ZO-1 coimmunoprecipitation with Cx30 and Cx43...
  43. Lutz S, Raine C, Brosnan C. Loss of astrocyte connexins 43 and 30 does not significantly alter susceptibility or severity of acute experimental autoimmune encephalomyelitis in mice. J Neuroimmunol. 2012;245:8-14 pubmed publisher
    We showed previously that mice deficient in astrocyte gap junctions Cx43 and Cx30 exhibit white matter vacuolation and hypomyelination...
  44. Chen J, Chen J, Zhu Y, Liang C, Zhao H. Deafness induced by Connexin 26 (GJB2) deficiency is not determined by endocochlear potential (EP) reduction but is associated with cochlear developmental disorders. Biochem Biophys Res Commun. 2014;448:28-32 pubmed publisher
    ..These data suggest that congenital deafness induced by Cx26 deficiency is not determined by EP reduction and may result from cochlear developmental disorders. ..
  45. Kamiya K, Yum S, Kurebayashi N, Muraki M, Ogawa K, Karasawa K, et al. Assembly of the cochlear gap junction macromolecular complex requires connexin 26. J Clin Invest. 2014;124:1598-607 pubmed publisher
    ..Surprisingly, CX26 deficiency is not compensated for by the closely related connexin CX30, which is abundantly expressed in the same cochlear cells...
  46. Johnson K, Zheng Q, Noben Trauth K. Strain background effects and genetic modifiers of hearing in mice. Brain Res. 2006;1091:79-88 pubmed
    ..Because modifier genes and digenic inheritance are not always distinguishable, we also include in this review several examples of digenic inheritance of hearing loss that have been reported in both mice and humans. ..
  47. Stockand J, Mironova E, Bugaj V, Rieg T, Insel P, Vallon V, et al. Purinergic inhibition of ENaC produces aldosterone escape. J Am Soc Nephrol. 2010;21:1903-11 pubmed publisher
    ..These data suggest that control of ENaC by purinergic signaling is necessary for aldosterone escape. ..
  48. Zhang J, Dublin P, Griemsmann S, Klein A, Brehm R, Bedner P, et al. Germ-line recombination activity of the widely used hGFAP-Cre and nestin-Cre transgenes. PLoS ONE. 2013;8:e82818 pubmed publisher
    ..Such control is essential to avoid pleiotropic effects due to germ-line deletion of loxP-flanked target genes and to maintain the CNS-restricted deletion status in transgenic mouse colonies. ..
  49. Boulay A, del Castillo F, Giraudet F, Hamard G, Giaume C, Petit C, et al. Hearing is normal without connexin30. J Neurosci. 2013;33:430-4 pubmed publisher
    Gjb2 and Gjb6, two contiguous genes respectively encoding the gap junction protein connexin26 (Cx26) and connexin 30 (Cx30) display overlapping expression in the inner ear...
  50. Locke D, Jamieson S, Stein T, Liu J, Hodgins M, Harris A, et al. Nature of Cx30-containing channels in the adult mouse mammary gland. Cell Tissue Res. 2007;328:97-107 pubmed
    ..Additionally, Cx30 is abundant in late-pregnant and early lactating gland epithelium...
  51. Houghton F, Barr K, Walter G, Gabriel H, Grummer R, Traub O, et al. Functional significance of gap junctional coupling in preimplantation development. Biol Reprod. 2002;66:1403-12 pubmed
    ..from reverse transcription-polymerase chain reaction analysis that the genes encoding 3 additional connexins (connexin 30 or beta6, connexin 36 or alpha9, and connexin 57 or alpha10) are also transcribed in preimplantation mouse ..
  52. Liu X, Yuan Y, Yan D, Ding E, Ouyang X, Fei Y, et al. Digenic inheritance of non-syndromic deafness caused by mutations at the gap junction proteins Cx26 and Cx31. Hum Genet. 2009;125:53-62 pubmed publisher
    ..We have excluded the possibility that mutations in exon 1 of GJB2 and the deletion of GJB6 are the second mutant allele in these Chinese heterozygous probands...
  53. Chever O, Dossi E, Pannasch U, Derangeon M, Rouach N. Astroglial networks promote neuronal coordination. Sci Signal. 2016;9:ra6 pubmed publisher
    Astrocytes interact with neurons to regulate network activity. Although the gap junction subunits connexin 30 and connexin 43 mediate the formation of extensive astroglial networks that cover large functional neuronal territories, their ..
  54. Roux L, Madar A, Lacroix M, Yi C, Benchenane K, Giaume C. Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow Oscillations. J Neurosci. 2015;35:15339-52 pubmed publisher
    ..This novel mechanism of neuroglial interaction could influence olfactory information processing by directly impacting the output of the olfactory bulb. ..
  55. Boulay A, Saubaméa B, Cisternino S, Mignon V, Mazeraud A, Jourdren L, et al. The Sarcoglycan complex is expressed in the cerebrovascular system and is specifically regulated by astroglial Cx30 channels. Front Cell Neurosci. 2015;9:9 pubmed publisher
    ..striking properties of astrocyte endfeet is their enrichment in gap junction proteins Connexin 43 and 30 (Cx43 and Cx30) allowing in particular for direct intercellular trafficking of ions and small signaling molecules through ..
  56. Berger A, Kelly J, Lajoie P, Shao Q, Laird D. Mutations in Cx30 that are linked to skin disease and non-syndromic hearing loss exhibit several distinct cellular pathologies. J Cell Sci. 2014;127:1751-64 pubmed publisher
    b>Connexin 30 (Cx30), a member of the large gap-junction protein family, plays a role in the homeostasis of the epidermis and inner ear through gap junctional intercellular communication (GJIC)...
  57. Zhu Y, Zong L, Mei L, Zhao H. Connexin26 gap junction mediates miRNA intercellular genetic communication in the cochlea and is required for inner ear development. Sci Rep. 2015;5:15647 pubmed publisher
    ..Connexin26 (Cx26) and Cx30 are predominant isoforms and co-express in the cochlea...
  58. Dahl E, Manthey D, Chen Y, Schwarz H, Chang Y, Lalley P, et al. Molecular cloning and functional expression of mouse connexin-30,a gap junction gene highly expressed in adult brain and skin. J Biol Chem. 1996;271:17903-10 pubmed
    ..This suggests that the polarity of voltage gating and the cationic selectivity of connexin-30 are similar to those of its closest homologue, connexin-26. ..
  59. Davis N, Phillips A, Becker D. Connexin dynamics in the privileged wound healing of the buccal mucosa. Wound Repair Regen. 2013;21:571-8 pubmed publisher
    ..This rapid down-regulation of all three connexins may in part underlie the rapid healing of the buccal mucosa. ..
  60. Rodriguez L, Simeonato E, Scimemi P, Anselmi F, Calì B, Crispino G, et al. Reduced phosphatidylinositol 4,5-bisphosphate synthesis impairs inner ear Ca2+ signaling and high-frequency hearing acquisition. Proc Natl Acad Sci U S A. 2012;109:14013-8 pubmed publisher
    ..This mouse model also suggests that PIPKI? may determine the level of gap junction contribution to cochlear development. ..
  61. Lin J, Lou N, Kang N, Takano T, Hu F, Han X, et al. A central role of connexin 43 in hypoxic preconditioning. J Neurosci. 2008;28:681-95 pubmed publisher
    ..Thus, adaptive modulation of Cx43 can offset environmental stress by adenosine-mediated elevation of cellular resistance. ..
  62. Qu Y, Tang W, Zhou B, Ahmad S, Chang Q, Li X, et al. Early developmental expression of connexin26 in the cochlea contributes to its dominate functional role in the cochlear gap junctions. Biochem Biophys Res Commun. 2012;417:245-50 pubmed publisher
    Mutations in Gjb2 and Gjb6 genes, coding for connexin26 (Cx26) and Cx30 proteins, respectively, are linked to about half of all cases of human autosomal non-syndromic prelingual deafness...
  63. Roux L, Benchenane K, Rothstein J, Bonvento G, Giaume C. Plasticity of astroglial networks in olfactory glomeruli. Proc Natl Acad Sci U S A. 2011;108:18442-6 pubmed publisher
    ..of glomerular astrocytes to the glomerulus center and the enriched expression of two astroglial connexins (Cx43 and Cx30) within the glomeruli...
  64. Unger T, Bette S, Zhang J, Theis M, Engele J. Connexin-deficiency affects expression levels of glial glutamate transporters within the cerebrum. Neurosci Lett. 2012;506:12-6 pubmed publisher
    ..transporters, we have now assessed their expression levels in brains of conditional Cx43 knockout mice, total Cx30 knockouts, as well as Cx43/Cx30 double knockouts...
  65. Cina C, Bechberger J, Ozog M, Naus C. Expression of connexins in embryonic mouse neocortical development. J Comp Neurol. 2007;504:298-313 pubmed
    ..family of gap junction proteins, Cx26, Cx36, Cx37, Cx43, and Cx45 were expressed in the developing cortex of mice, Cx30 and Cx32 were absent, while Cx40 was expressed at a very low level...
  66. Koulakoff A, Ezan P, Giaume C. Neurons control the expression of connexin 30 and connexin 43 in mouse cortical astrocytes. Glia. 2008;56:1299-311 pubmed publisher
    ..The two main connexins, Cx30 and Cx43, that form these junctions in astrocytes of adult brain display different developmental and regional ..
  67. Langer J, Gerkau N, Derouiche A, Kleinhans C, Moshrefi Ravasdjani B, Fredrich M, et al. Rapid sodium signaling couples glutamate uptake to breakdown of ATP in perivascular astrocyte endfeet. Glia. 2017;65:293-308 pubmed publisher
    ..of ∼120 µm/s and directly propagated from stimulated into neighboring endfeet; this spread was omitted in Cx30/Cx43 double-deficient mice...
  68. Sipos A, Vargas S, Toma I, Hanner F, Willecke K, Peti Peterdi J. Connexin 30 deficiency impairs renal tubular ATP release and pressure natriuresis. J Am Soc Nephrol. 2009;20:1724-32 pubmed publisher
    ..Several connexin (Cx) isoforms form mechanosensitive, ATP-permeable hemichannels. We localized Cx30 to the nonjunctional apical membrane of cells in the distal nephron and tested whether Cx30 participates in ..
  69. Mironova E, Peti Peterdi J, Bugaj V, Stockand J. Diminished paracrine regulation of the epithelial Na+ channel by purinergic signaling in mice lacking connexin 30. J Biol Chem. 2011;286:1054-60 pubmed publisher
    We tested whether ATP release through Connexin 30 (Cx30) is part of a local purinergic regulatory system intrinsic to the aldosterone-sensitive distal nephron (ASDN) important for proper control of sodium excretion; if changes in sodium ..
  70. Ernst C, Nagy C, Kim S, Yang J, Deng X, Hellstrom I, et al. Dysfunction of astrocyte connexins 30 and 43 in dorsal lateral prefrontal cortex of suicide completers. Biol Psychiatry. 2011;70:312-9 pubmed publisher
    ..Animal behavioral experiments were done to control for drug and alcohol effects. We found reduced expression of Cx30 and Cx43 in DLPFC of suicide completers...
  71. Majoul I, Gao L, Betzig E, Onichtchouk D, Butkevich E, Kozlov Y, et al. Fast structural responses of gap junction membrane domains to AB5 toxins. Proc Natl Acad Sci U S A. 2013;110:E4125-33 pubmed publisher
    ..Our data demonstrate very fast dynamics (in the millisecond-to-second range) within GJ plaques, which previously were considered to be relatively stable, long-lived structures. ..
  72. Lynn B, Tress O, May D, Willecke K, Nagy J. Ablation of connexin30 in transgenic mice alters expression patterns of connexin26 and connexin32 in glial cells and leptomeninges. Eur J Neurosci. 2011;34:1783-93 pubmed publisher
    Expression of connexin26 (Cx26), Cx30 and Cx43 in astrocytes and expression of Cx29, Cx32 and Cx47 in oligodendrocytes of adult rodent brain has been well documented, as has the interdependence of connexin expression patterns of ..
  73. Bosen F, Schütz M, Beinhauer A, Strenzke N, Franz T, Willecke K. The Clouston syndrome mutation connexin30 A88V leads to hyperproliferation of sebaceous glands and hearing impairments in mice. FEBS Lett. 2014;588:1795-801 pubmed publisher
    Distinct mutations in the gap junction protein connexin30 (Cx30) can cause the ectodermal dysplasia Clouston syndrome in humans...
  74. Ezan P, André P, Cisternino S, Saubamea B, Boulay A, Doutremer S, et al. Deletion of astroglial connexins weakens the blood-brain barrier. J Cereb Blood Flow Metab. 2012;32:1457-67 pubmed publisher
    ..striking properties of astrocyte endfeet is their enrichment in gap junction protein connexins 43 and 30 (Cx43 and Cx30) allowing for direct intercellular trafficking of ions and small signaling molecules through perivascular ..
  75. May D, Tress O, Seifert G, Willecke K. Connexin47 protein phosphorylation and stability in oligodendrocytes depend on expression of Connexin43 protein in astrocytes. J Neurosci. 2013;33:7985-96 pubmed publisher
    ..These results further unravel the complexity of panglial networks and show that results of previous studies using astrocytic Cx43-deficient mice have to be reconsidered. ..
  76. von Maltzahn J, Euwens C, Willecke K, Sohl G. The novel mouse connexin39 gene is expressed in developing striated muscle fibers. J Cell Sci. 2004;117:5381-92 pubmed
    ..As expression of no other known connexin could be verified in these cells, intercellular dye transfer might result from functional expression of Cx39 in developing striated muscle fibers. ..
  77. Huang C, Han X, Li X, Lam E, Peng W, Lou N, et al. Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury. J Neurosci. 2012;32:3333-8 pubmed publisher
    ..for astrocytic ATP release, we here evaluated the impact on post-traumatic ATP release of deletion of connexins (Cx30/Cx43) in astrocytes...