Gjb5

Summary

Gene Symbol: Gjb5
Description: gap junction protein, beta 5
Alias: Cnx31.1, Cx31.1, Gjb-5, gap junction beta-5 protein, connexin-31.1, gap junction membrane channel protein beta 5
Species: mouse
Products:     Gjb5

Top Publications

  1. Davies T, Barr K, Jones D, Zhu D, Kidder G. Multiple members of the connexin gene family participate in preimplantation development of the mouse. Dev Genet. 1996;18:234-43 pubmed
    ..The expression of multiple connexin genes during this early period of embryogenesis (when there are only two distinct cell types) raises questions about the functional significance of connexin diversity in this context. ..
  2. Juneja S. mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouse. Indian J Physiol Pharmacol. 2003;47:147-56 pubmed
    ..In developmentally impaired fetal ovary, only Cx43 was not expressed as expected but other three connexins were expresed. The study may be useful in interpreting human testis defects in infertility cases. ..
  3. Kibschull M, Magin T, Traub O, Winterhager E. Cx31 and Cx43 double-deficient mice reveal independent functions in murine placental and skin development. Dev Dyn. 2005;233:853-63 pubmed
    ..Therefore, in epidermal and preimplantation development, gap junctional communication can probably be compensated by other isoforms coexpressed with Cx31 and Cx43. ..
  4. Hennemann H, Dahl E, White J, Schwarz H, Lalley P, Chang S, et al. Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin. J Biol Chem. 1992;267:17225-33 pubmed
    ..Microinjection of Cx30.3, but not Cx31.1 cRNA, into Xenopus oocyte pairs induced formation of functional gap junction channels with unique voltage-gated parameters compared to other connexins expressed similarly. ..
  5. Richard G, Smith L, Bailey R, Itin P, Hohl D, Epstein E, et al. Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis. Nat Genet. 1998;20:366-9 pubmed
    ..of epidermally expressed connexin genes led us to characterize the human homologues of GJB3 (encoding Cx31) and GJB5 (encoding Cx31.1). GJB3, GJB5 and GJA4 were localized to a 1.1-Mb YAC in the candidate interval...
  6. Maeda Y, Funata N, Takahama S, Sugata Y, Yonekawa H. Two interactive genes responsible for a new inherited cataract (RCT) in the mouse. Mamm Genome. 2001;12:278-83 pubmed
    ..The rct locus essential for the onset of the cataract was tightly linked to D4Mit278 on Chromosome (Chr) 4 with no recombination. The mrct locus was closely linked to D5Mit239 (chi2 = 66.3, P < 0.00001) on Chr 5. ..
  7. Houghton F, Barr K, Walter G, Gabriel H, Grummer R, Traub O, et al. Functional significance of gap junctional coupling in preimplantation development. Biol Reprod. 2002;66:1403-12 pubmed
    ..New evidence of this diversification is presented using rat blastocyst outgrowths. ..
  8. Lopez Bigas N, Arbones M, Estivill X, Simonneau L. Expression profiles of the connexin genes, Gjb1 and Gjb3, in the developing mouse cochlea. Mech Dev. 2002;119 Suppl 1:S111-5 pubmed
    ..In the adult cochlea Gjb1 transcripts disappeared while Gjb3 expression remained present in fibrocytes with specific expression patterns. ..
  9. Sohl G, Willecke K. An update on connexin genes and their nomenclature in mouse and man. Cell Commun Adhes. 2003;10:173-80 pubmed
    ..Furthermore, this short review contains an update on phenotypic correlations between connexin deficient mice and patients bearing mutations in their orthologous connexin genes. ..
  10. Buniello A, Montanaro D, Volinia S, Gasparini P, Marigo V. An expression atlas of connexin genes in the mouse. Genomics. 2004;83:812-20 pubmed

Detail Information

Publications15

  1. Davies T, Barr K, Jones D, Zhu D, Kidder G. Multiple members of the connexin gene family participate in preimplantation development of the mouse. Dev Genet. 1996;18:234-43 pubmed
    ..The expression of multiple connexin genes during this early period of embryogenesis (when there are only two distinct cell types) raises questions about the functional significance of connexin diversity in this context. ..
  2. Juneja S. mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouse. Indian J Physiol Pharmacol. 2003;47:147-56 pubmed
    ..In developmentally impaired fetal ovary, only Cx43 was not expressed as expected but other three connexins were expresed. The study may be useful in interpreting human testis defects in infertility cases. ..
  3. Kibschull M, Magin T, Traub O, Winterhager E. Cx31 and Cx43 double-deficient mice reveal independent functions in murine placental and skin development. Dev Dyn. 2005;233:853-63 pubmed
    ..Therefore, in epidermal and preimplantation development, gap junctional communication can probably be compensated by other isoforms coexpressed with Cx31 and Cx43. ..
  4. Hennemann H, Dahl E, White J, Schwarz H, Lalley P, Chang S, et al. Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin. J Biol Chem. 1992;267:17225-33 pubmed
    ..Microinjection of Cx30.3, but not Cx31.1 cRNA, into Xenopus oocyte pairs induced formation of functional gap junction channels with unique voltage-gated parameters compared to other connexins expressed similarly. ..
  5. Richard G, Smith L, Bailey R, Itin P, Hohl D, Epstein E, et al. Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis. Nat Genet. 1998;20:366-9 pubmed
    ..of epidermally expressed connexin genes led us to characterize the human homologues of GJB3 (encoding Cx31) and GJB5 (encoding Cx31.1). GJB3, GJB5 and GJA4 were localized to a 1.1-Mb YAC in the candidate interval...
  6. Maeda Y, Funata N, Takahama S, Sugata Y, Yonekawa H. Two interactive genes responsible for a new inherited cataract (RCT) in the mouse. Mamm Genome. 2001;12:278-83 pubmed
    ..The rct locus essential for the onset of the cataract was tightly linked to D4Mit278 on Chromosome (Chr) 4 with no recombination. The mrct locus was closely linked to D5Mit239 (chi2 = 66.3, P < 0.00001) on Chr 5. ..
  7. Houghton F, Barr K, Walter G, Gabriel H, Grummer R, Traub O, et al. Functional significance of gap junctional coupling in preimplantation development. Biol Reprod. 2002;66:1403-12 pubmed
    ..New evidence of this diversification is presented using rat blastocyst outgrowths. ..
  8. Lopez Bigas N, Arbones M, Estivill X, Simonneau L. Expression profiles of the connexin genes, Gjb1 and Gjb3, in the developing mouse cochlea. Mech Dev. 2002;119 Suppl 1:S111-5 pubmed
    ..In the adult cochlea Gjb1 transcripts disappeared while Gjb3 expression remained present in fibrocytes with specific expression patterns. ..
  9. Sohl G, Willecke K. An update on connexin genes and their nomenclature in mouse and man. Cell Commun Adhes. 2003;10:173-80 pubmed
    ..Furthermore, this short review contains an update on phenotypic correlations between connexin deficient mice and patients bearing mutations in their orthologous connexin genes. ..
  10. Buniello A, Montanaro D, Volinia S, Gasparini P, Marigo V. An expression atlas of connexin genes in the mouse. Genomics. 2004;83:812-20 pubmed
  11. Zheng Fischhöfer Q, Kibschull M, Schnichels M, Kretz M, Petrasch Parwez E, Strotmann J, et al. Characterization of connexin31.1-deficient mice reveals impaired placental development. Dev Biol. 2007;312:258-71 pubmed
    ..We conclude that Connexin31.1 is critical for normal placental development but appears to be functionally compensated by other connexin isoforms in the embryo proper and adult mouse. ..
  12. Dere E, Zheng Fischhöfer Q, Viggiano D, Gironi Carnevale U, Ruocco L, Zlomuzica A, et al. Connexin31.1 deficiency in the mouse impairs object memory and modulates open-field exploration, acetylcholine esterase levels in the striatum, and cAMP response element-binding protein levels in the striatum and piriform cortex. Neuroscience. 2008;153:396-405 pubmed publisher
    ..In conclusion, gap-junctions featuring the Cx31.1 protein might be involved in open-field exploration as well as object memory and modulate levels of AChE and CREB in the striatum and piriform cortex. ..
  13. von Maltzahn J, Euwens C, Willecke K, Sohl G. The novel mouse connexin39 gene is expressed in developing striated muscle fibers. J Cell Sci. 2004;117:5381-92 pubmed
    ..As expression of no other known connexin could be verified in these cells, intercellular dye transfer might result from functional expression of Cx39 in developing striated muscle fibers. ..
  14. Frankenberg S, Smith L, Greenfield A, Zernicka Goetz M. Novel gene expression patterns along the proximo-distal axis of the mouse embryo before gastrulation. BMC Dev Biol. 2007;7:8 pubmed
    ..5. At E5.5, prospective anterior markers are expressed at the distal tip of the embryo, whereas prospective posterior markers are expressed more proximally, close to the boundary with the extraembryonic region...
  15. Kibschull M, Colaco K, Matysiak Zablocki E, Winterhager E, Lye S. Connexin31.1 (Gjb5) deficiency blocks trophoblast stem cell differentiation and delays placental development. Stem Cells Dev. 2014;23:2649-60 pubmed publisher
    The gap junction channel forming connexins (Cx) Cx31 (Gjb3) and Cx31.1 (Gjb5) are co-expressed in the mouse trophoblast lineage...