Gjb1

Summary

Gene Symbol: Gjb1
Description: gap junction protein, beta 1
Alias: Cnx32, Cx32, connexin-32, gap junction beta-1 protein, connexin 32, connexin-43, gap junction membrane channel protein beta 1
Species: mouse
Products:     Gjb1

Top Publications

  1. Parenti R, Cicirata F, Zappala A, Catania A, La Delia F, Cicirata V, et al. Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity. Glia. 2010;58:1594-609 pubmed publisher
    ..Since the expression of Cx47 in developing oligodendrocytes preceded those of Cx32 and Cx29, a role of Cx47 in myelinogenesis was postulated...
  2. Simon A, Goodenough D. Diverse functions of vertebrate gap junctions. Trends Cell Biol. 1998;8:477-83 pubmed
  3. Menichella D, Goodenough D, Sirkowski E, Scherer S, Paul D. Connexins are critical for normal myelination in the CNS. J Neurosci. 2003;23:5963-73 pubmed
    Mutations in Cx32, a gap-junction channel-forming protein, result in X-linked Charcot-Marie-Tooth disease, a demyelinating disease of the peripheral nervous system...
  4. Sargiannidou I, Vavlitou N, Aristodemou S, Hadjisavvas A, Kyriacou K, Scherer S, et al. Connexin32 mutations cause loss of function in Schwann cells and oligodendrocytes leading to PNS and CNS myelination defects. J Neurosci. 2009;29:4736-49 pubmed publisher
    The gap junction (GJ) protein connexin32 (Cx32) is expressed by myelinating Schwann cells and oligodendrocytes and is mutated in X-linked Charcot-Marie-Tooth disease...
  5. Duffy H, Iacobas I, Hotchkiss K, Hirst Jensen B, Bosco A, Dandachi N, et al. The gap junction protein connexin32 interacts with the Src homology 3/hook domain of discs large homolog 1. J Biol Chem. 2007;282:9789-96 pubmed
    ..Here we describe studies indicating that Cx32 interacts with a PDZ-containing scaffolding protein, Dlgh1 (Discs Large homolog 1)...
  6. Kamasawa N, Sik A, Morita M, Yasumura T, Davidson K, Nagy J, et al. Connexin-47 and connexin-32 in gap junctions of oligodendrocyte somata, myelin sheaths, paranodal loops and Schmidt-Lanterman incisures: implications for ionic homeostasis and potassium siphoning. Neuroscience. 2005;136:65-86 pubmed
    The subcellular distributions and co-associations of the gap junction-forming proteins connexin 47 and connexin 32 were investigated in oligodendrocytes of adult mouse and rat CNS...
  7. Moennikes O, Buchmann A, Ott T, Willecke1 K, Schwarz M. The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains. Carcinogenesis. 1999;20:1379-82 pubmed
    Connexin32 (Cx32) is the major gap junctional protein in mouse liver...
  8. Altevogt B, Kleopa K, Postma F, Scherer S, Paul D. Connexin29 is uniquely distributed within myelinating glial cells of the central and peripheral nervous systems. J Neurosci. 2002;22:6458-70 pubmed
    Although both Schwann cells and oligodendrocytes express connexin32 (Cx32), the loss of this connexin causes demyelination only in the PNS...
  9. Nagy J, Ionescu A, Lynn B, Rash J. Coupling of astrocyte connexins Cx26, Cx30, Cx43 to oligodendrocyte Cx29, Cx32, Cx47: Implications from normal and connexin32 knockout mice. Glia. 2003;44:205-18 pubmed
    ..A/O) gap junctions contain multiple connexins (Cx), including Cx26, Cx30, and Cx43 on the astrocyte side, and Cx32, Cx29, and Cx47 on the oligodendrocyte side...
  10. Temme A, Buchmann A, Gabriel H, Nelles E, Schwarz M, Willecke K. High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32. Curr Biol. 1997;7:713-6 pubmed
    ..We have previously shown that transgenic mice that lack connexin32 (Cx32), the major gap junction protein expressed in hepatocytes, express lower levels of a second hepatic gap junction ..

Detail Information

Publications87

  1. Parenti R, Cicirata F, Zappala A, Catania A, La Delia F, Cicirata V, et al. Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity. Glia. 2010;58:1594-609 pubmed publisher
    ..Since the expression of Cx47 in developing oligodendrocytes preceded those of Cx32 and Cx29, a role of Cx47 in myelinogenesis was postulated...
  2. Simon A, Goodenough D. Diverse functions of vertebrate gap junctions. Trends Cell Biol. 1998;8:477-83 pubmed
  3. Menichella D, Goodenough D, Sirkowski E, Scherer S, Paul D. Connexins are critical for normal myelination in the CNS. J Neurosci. 2003;23:5963-73 pubmed
    Mutations in Cx32, a gap-junction channel-forming protein, result in X-linked Charcot-Marie-Tooth disease, a demyelinating disease of the peripheral nervous system...
  4. Sargiannidou I, Vavlitou N, Aristodemou S, Hadjisavvas A, Kyriacou K, Scherer S, et al. Connexin32 mutations cause loss of function in Schwann cells and oligodendrocytes leading to PNS and CNS myelination defects. J Neurosci. 2009;29:4736-49 pubmed publisher
    The gap junction (GJ) protein connexin32 (Cx32) is expressed by myelinating Schwann cells and oligodendrocytes and is mutated in X-linked Charcot-Marie-Tooth disease...
  5. Duffy H, Iacobas I, Hotchkiss K, Hirst Jensen B, Bosco A, Dandachi N, et al. The gap junction protein connexin32 interacts with the Src homology 3/hook domain of discs large homolog 1. J Biol Chem. 2007;282:9789-96 pubmed
    ..Here we describe studies indicating that Cx32 interacts with a PDZ-containing scaffolding protein, Dlgh1 (Discs Large homolog 1)...
  6. Kamasawa N, Sik A, Morita M, Yasumura T, Davidson K, Nagy J, et al. Connexin-47 and connexin-32 in gap junctions of oligodendrocyte somata, myelin sheaths, paranodal loops and Schmidt-Lanterman incisures: implications for ionic homeostasis and potassium siphoning. Neuroscience. 2005;136:65-86 pubmed
    The subcellular distributions and co-associations of the gap junction-forming proteins connexin 47 and connexin 32 were investigated in oligodendrocytes of adult mouse and rat CNS...
  7. Moennikes O, Buchmann A, Ott T, Willecke1 K, Schwarz M. The effect of connexin32 null mutation on hepatocarcinogenesis in different mouse strains. Carcinogenesis. 1999;20:1379-82 pubmed
    Connexin32 (Cx32) is the major gap junctional protein in mouse liver...
  8. Altevogt B, Kleopa K, Postma F, Scherer S, Paul D. Connexin29 is uniquely distributed within myelinating glial cells of the central and peripheral nervous systems. J Neurosci. 2002;22:6458-70 pubmed
    Although both Schwann cells and oligodendrocytes express connexin32 (Cx32), the loss of this connexin causes demyelination only in the PNS...
  9. Nagy J, Ionescu A, Lynn B, Rash J. Coupling of astrocyte connexins Cx26, Cx30, Cx43 to oligodendrocyte Cx29, Cx32, Cx47: Implications from normal and connexin32 knockout mice. Glia. 2003;44:205-18 pubmed
    ..A/O) gap junctions contain multiple connexins (Cx), including Cx26, Cx30, and Cx43 on the astrocyte side, and Cx32, Cx29, and Cx47 on the oligodendrocyte side...
  10. Temme A, Buchmann A, Gabriel H, Nelles E, Schwarz M, Willecke K. High incidence of spontaneous and chemically induced liver tumors in mice deficient for connexin32. Curr Biol. 1997;7:713-6 pubmed
    ..We have previously shown that transgenic mice that lack connexin32 (Cx32), the major gap junction protein expressed in hepatocytes, express lower levels of a second hepatic gap junction ..
  11. Janssen E, Kemp S, Hensels G, Sie O, De Die Smulders C, Hoogendijk J, et al. Connexin32 gene mutations in X-linked dominant Charcot-Marie-Tooth disease (CMTX1). Hum Genet. 1997;99:501-5 pubmed
    ..The nucleotide changes resulted in seven amino-acid substitutions and one premature stop codon. ..
  12. Menichella D, Majdan M, Awatramani R, Goodenough D, Sirkowski E, Scherer S, et al. Genetic and physiological evidence that oligodendrocyte gap junctions contribute to spatial buffering of potassium released during neuronal activity. J Neurosci. 2006;26:10984-91 pubmed
    Mice lacking the K+ channel Kir4.1 or both connexin32 (Cx32) and Cx47 exhibit myelin-associated vacuoles, raising the possibility that oligodendrocytes, and the connexins they express, contribute to recycling the K+ evolved during ..
  13. Ahn M, Lee J, Gustafsson A, Enriquez A, Lancaster E, Sul J, et al. Cx29 and Cx32, two connexins expressed by myelinating glia, do not interact and are functionally distinct. J Neurosci Res. 2008;86:992-1006 pubmed
    In rodents, oligodendrocytes and myelinating Schwann cells express connexin32 (Cx32) and Cx29, which have different localizations in the two cell types...
  14. Hennemann H, Kozjek G, Dahl E, Nicholson B, Willecke K. Molecular cloning of mouse connexins26 and -32: similar genomic organization but distinct promoter sequences of two gap junction genes. Eur J Cell Biol. 1992;58:81-9 pubmed
    ..The promoter region of the mouse Cx32 gene contains two putative binding sites for the transcription factor HNF-1 and consensus motifs for NF-1 as well ..
  15. Nelles E, Bützler C, Jung D, Temme A, Gabriel H, Dahl U, et al. Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice. Proc Natl Acad Sci U S A. 1996;93:9565-70 pubmed
    ..It is possible, however, that they may develop neurodegenerative symptoms at older age. ..
  16. Kleopa K, Orthmann J, Enriquez A, Paul D, Scherer S. Unique distributions of the gap junction proteins connexin29, connexin32, and connexin47 in oligodendrocytes. Glia. 2004;47:346-57 pubmed
    Oligodendrocytes of adult rodents express three different connexins: connexin29 (Cx29), Cx32, and Cx47...
  17. Anzini P, Neuberg D, Schachner M, Nelles E, Willecke K, Zielasek J, et al. Structural abnormalities and deficient maintenance of peripheral nerve myelin in mice lacking the gap junction protein connexin 32. J Neurosci. 1997;17:4545-51 pubmed
    Mutations affecting the connexin 32 (Cx32) gene are associated with the X-linked form of the hereditary peripheral neuropathy Charcot-Marie-Tooth disease (CMTX)...
  18. Li X, Penes M, Odermatt B, Willecke K, Nagy J. Ablation of Cx47 in transgenic mice leads to the loss of MUPP1, ZONAB and multiple connexins at oligodendrocyte-astrocyte gap junctions. Eur J Neurosci. 2008;28:1503-17 pubmed publisher
    Oligodendrocytes in CNS are linked to astrocytes by heterotypic gap junctions composed of Cx32 and Cx47 in oligodendrocytes and Cx30 and Cx43 in astrocytes. These gap junctions also harbour regulatory proteins, including ZO-1 and ZONAB...
  19. Miro Casas E, Ruiz Meana M, Agullo E, Stahlhofen S, Rodriguez Sinovas A, Cabestrero A, et al. Connexin43 in cardiomyocyte mitochondria contributes to mitochondrial potassium uptake. Cardiovasc Res. 2009;83:747-56 pubmed publisher
    ..flux was assessed in wild-type mice using hemichannel blockers and Cx43KI32 mice in which Cx43 had been replaced by Cx32. Uptake of the Cx43 hemichannel-permeant dye Lucifer Yellow was reduced in mitochondria from wild-type mice by two ..
  20. Odermatt B, Wellershaus K, Wallraff A, Seifert G, Degen J, Euwens C, et al. Connexin 47 (Cx47)-deficient mice with enhanced green fluorescent protein reporter gene reveal predominant oligodendrocytic expression of Cx47 and display vacuolized myelin in the CNS. J Neurosci. 2003;23:4549-59 pubmed
    ..Initial analyses of Cx32/Cx47-double-deficient mice showed that these mice developed an action tremor and died on average at 51 d after ..
  21. Maglione M, Tress O, Haas B, Karram K, Trotter J, Willecke K, et al. Oligodendrocytes in mouse corpus callosum are coupled via gap junction channels formed by connexin47 and connexin32. Glia. 2010;58:1104-17 pubmed publisher
    ..Oligodendrocytes are known to express Cx47, Cx32 and Cx29, astrocytes Cx43 and Cx30. In Cx47-deficient mice, the number of coupled cells was reduced by 80%...
  22. Baloh R, Strickland A, Ryu E, Le N, Fahrner T, Yang M, et al. Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation. J Neurosci. 2009;29:2312-21 pubmed publisher
  23. Sohl G, Willecke K. An update on connexin genes and their nomenclature in mouse and man. Cell Commun Adhes. 2003;10:173-80 pubmed
    ..Furthermore, this short review contains an update on phenotypic correlations between connexin deficient mice and patients bearing mutations in their orthologous connexin genes. ..
  24. Gabriel H, Jung D, Bützler C, Temme A, Traub O, Winterhager E, et al. Transplacental uptake of glucose is decreased in embryonic lethal connexin26-deficient mice. J Cell Biol. 1998;140:1453-61 pubmed
  25. Buniello A, Montanaro D, Volinia S, Gasparini P, Marigo V. An expression atlas of connexin genes in the mouse. Genomics. 2004;83:812-20 pubmed
  26. Martini R. Animal models for inherited peripheral neuropathies. J Anat. 1997;191 ( Pt 3):321-36 pubmed
    ..Mutations in 3 distinct myelin genes, PMP22, P0, and connexin 32 cause the 3 major demyelinating subtypes of Charcot-Marie-Tooth (CMT) disease, CMT1A, CMT1B and CMTX, ..
  27. Li J, Habbes H, Eiberger J, Willecke K, Dermietzel R, Meier C. Analysis of connexin expression during mouse Schwann cell development identifies connexin29 as a novel marker for the transition of neural crest to precursor cells. Glia. 2007;55:93-103 pubmed
    ..In mature myelin-forming Schwann cells, expression of multiple connexins, i.e. connexin (Cx) 43, Cx29, Cx32, and Cx46 (after nerve injury) has been detected...
  28. Rash J, Olson C, Pouliot W, Davidson K, Yasumura T, Furman C, et al. Connexin36 vs. connexin32, "miniature" neuronal gap junctions, and limited electrotonic coupling in rodent suprachiasmatic nucleus. Neuroscience. 2007;149:350-71 pubmed
  29. Sotkis A, Wang X, Yasumura T, Peracchia L, Persechini A, Rash J, et al. Calmodulin colocalizes with connexins and plays a direct role in gap junction channel gating. Cell Commun Adhes. 2001;8:277-81 pubmed
    ..EF hand pair with a duplication of the C-terminal pair, drastically increased the chemical gating sensitivity of Cx32 channels and decreased their Vj sensitivity...
  30. Da Y, Wang W, Liu Z, Chen H, Di L, Previch L, et al. Aberrant trafficking of a Leu89Pro connexin32 mutant associated with X-linked dominant Charcot-Marie-Tooth disease. Neurol Res. 2016;38:897-902 pubmed publisher
    To determine the functional abnormalities of the Leu89Pro mutation in connexin32 (CX32), which we have previously reported is present within an X-linked dominant Charcot-Marie-Tooth disease family...
  31. Rukstalis J, Kowalik A, Zhu L, Lidington D, Pin C, Konieczny S. Exocrine specific expression of Connexin32 is dependent on the basic helix-loop-helix transcription factor Mist1. J Cell Sci. 2003;116:3315-25 pubmed
    ..In pancreatic acini, the connexin26 (Cx26) and connexin32 (Cx32) proteins form functional channels that coordinate the secretion of digestive enzymes...
  32. Neuberg D, Carenini S, Schachner M, Martini R, Suter U. Accelerated demyelination of peripheral nerves in mice deficient in connexin 32 and protein zero. J Neurosci Res. 1998;53:542-50 pubmed
    Mutant mice that lack either protein zero (P0) or connexin 32 (Cx32) were generated previously to investigate the function of these myelin proteins in peripheral nerves and to assess the value of these mice as animal models for ..
  33. Wasseff S, Scherer S. Cx32 and Cx47 mediate oligodendrocyte:astrocyte and oligodendrocyte:oligodendrocyte gap junction coupling. Neurobiol Dis. 2011;42:506-13 pubmed publisher
    ..to be exclusively coupled to astrocytes (O:A coupling) via heterotypic gap junctions composed of Cx47:Cx43 and Cx32:Cx30...
  34. Fowler S, Akins M, Zhou H, Figeys D, Bennett S. The liver connexin32 interactome is a novel plasma membrane-mitochondrial signaling nexus. J Proteome Res. 2013;12:2597-610 pubmed publisher
    ..Complex formation increases the pool of sideroflexin-1 that is present at the plasma membrane. Together, these data identify a novel plasma membrane/mitochondrial signaling nexus in the connexin32 interactome. ..
  35. Miragall F, Hwang T, Traub O, Hertzberg E, Dermietzel R. Expression of connexins in the developing olfactory system of the mouse. J Comp Neurol. 1992;325:359-78 pubmed
    ..Moreover, our findings indicate that although expression of connexin43 in the olfactory system is developmentally regulated, it is not directly associated with the neuronal cell turnover of the olfactory epithelium. ..
  36. Kotsias B, Salim M, Peracchia L, Peracchia C. Interplay between cystic fibrosis transmembrane regulator and gap junction channels made of connexins 45, 40, 32 and 50 expressed in oocytes. J Membr Biol. 2006;214:1-8 pubmed
    ..interaction between CFTR and gap junction channels, we coexpressed in Xenopus oocytes CFTR and either Cx45, Cx40, Cx32 or Cx50 and monitored junctional conductance (G (j)) and its sensitivity to transjunctional voltage (V (j)) by the ..
  37. Clotman F, Jacquemin P, Plumb Rudewiez N, Pierreux C, Van Der Smissen P, Dietz H, et al. Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors. Genes Dev. 2005;19:1849-54 pubmed
    ..Thus, a gradient of activin/TGFbeta signaling modulated by Onecut factors is required to segregate the hepatocytic and the biliary lineages. ..
  38. Laird D, Yancey S, Bugga L, Revel J. Connexin expression and gap junction communication compartments in the developing mouse limb. Dev Dyn. 1992;195:153-61 pubmed
    ..and confocal microscopy together with 3-dimensional reconstruction software to map the distribution of Cx43 and Cx32 in 11-14.5 days postcoitum (dpc) mouse limbs...
  39. Bonal C, Thorel F, Ait Lounis A, Reith W, Trumpp A, Herrera P. Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice. Gastroenterology. 2009;136:309-319.e9 pubmed publisher
  40. Ayad W, Locke D, Koreen I, Harris A. Heteromeric, but not homomeric, connexin channels are selectively permeable to inositol phosphates. J Biol Chem. 2006;281:16727-39 pubmed
    Previous work has shown that channels formed by both connexin (Cx)26 and Cx32 (heteromeric Cx26/Cx32 hemichannels) are selectively permeable to cAMP and cGMP...
  41. He S, Weiler R, Vaney D. Endogenous dopaminergic regulation of horizontal cell coupling in the mammalian retina. J Comp Neurol. 2000;418:33-40 pubmed
    ..It has been proposed that the gap junctional coupling between horizontal cells is mediated by connexin 32 (Cx32), but the pattern and dopaminergic regulation of horizontal cell coupling were unaffected in Cx32-..
  42. Moon Y, Choi S, Kim K, Kim H, Sun W. Expression of connexin29 and 32 in the penumbra region after traumatic brain injury of mice. Neuroreport. 2010;21:1135-9 pubmed publisher
    ..We found that the expressions of two Cx family members, Cx29 and Cx32, were progressively increased in the sharp border of injury penumbra regions after cryotraumatic brain injury...
  43. Groh J, Klein I, Hollmann C, Wettmarshausen J, Klein D, Martini R. CSF-1-activated macrophages are target-directed and essential mediators of Schwann cell dedifferentiation and dysfunction in Cx32-deficient mice. Glia. 2015;63:977-86 pubmed publisher
    We investigated connexin 32 (Cx32)-deficient mice, a model for the X-linked form of Charcot-Marie-Tooth neuropathy (CMT1X), regarding the impact of low-grade inflammation on Schwann cell phenotype...
  44. Prost G, Bernier Valentin F, Croset M, Rousset B. Impact of connexin32 deletion on E7 or RET/PTC3 oncogene-driven growth and neoplastic transformation of the thyroid gland. Endocr Relat Cancer. 2009;16:873-84 pubmed publisher
    ..Using genetically modified mice, we previously found that Cx32 acts as a down-regulator of growth in normal thyroid gland...
  45. Sohl G, Gillen C, Bosse F, Gleichmann M, Muller H, Willecke K. A second alternative transcript of the gap junction gene connexin32 is expressed in murine Schwann cells and modulated in injured sciatic nerve. Eur J Cell Biol. 1996;69:267-75 pubmed
    Four connexin32 (Cx32) cDNA clones isolated from a rat sciatic nerve cDNA library differ in the nucleotide sequence of their 5' untranslated region (UTR) from the corresponding Cx32 cDNA clones previously characterized from liver...
  46. Sánchez H, Orellana J, Verselis V, Saez J. Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells. Am J Physiol Cell Physiol. 2009;297:C665-78 pubmed publisher
    ..Here the effects of metabolic inhibition (MI), an in vitro model of ischemia, on the activity of mouse Cx32 HCs were examined...
  47. Sohl G, Eiberger J, Jung Y, Kozak C, Willecke K. The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development. Biol Chem. 2001;382:973-8 pubmed
    ..Our expression data suggest that the new connexin gene is active in myelin-forming glial cells. ..
  48. Boink G, Lau D, Shlapakova I, Sosunov E, Anyukhovsky E, Driessen H, et al. SkM1 and Cx32 improve conduction in canine myocardial infarcts yet only SkM1 is antiarrhythmic. Cardiovasc Res. 2012;94:450-9 pubmed publisher
    ..of green fluorescent protein (GFP; sham), the skeletal muscle sodium channel (SkM1), the liver-specific connexin (Cx32), and SkM1/Cx32 in the subacute canine infarct...
  49. Wiencken Barger A, Djukic B, Casper K, McCarthy K. A role for Connexin43 during neurodevelopment. Glia. 2007;55:675-86 pubmed
    ..In conclusion, neurodevelopment of Shuffler/Cx43 cKO mice is abnormal, and the observed cellular phenotype may explain behavioral disturbances seen in these animals as well as in humans carrying Cx43 mutations. ..
  50. King T, Lampe P. Altered tumor biology and tumorigenesis in irradiated and chemical carcinogen-treated single and combined connexin32/p27Kip1-deficient mice. Cell Commun Adhes. 2005;12:293-305 pubmed
    Connexin32 knockout mice (Cx32-KO) exhibit increased chemical and radiation-induced liver and lung tumorigenesis...
  51. Moennikes O, Stahl S, Bannasch P, Buchmann A, Schwarz M. WY-14,643-mediated promotion of hepatocarcinogenesis in connexin32-wild-type and connexin32-null mice. Carcinogenesis. 2003;24:1561-5 pubmed
    Connexin32 (Cx32) is the major gap junction forming protein in liver and lack of functional Cx32 enhances hepatocarcinogenesis...
  52. Xu X, Francis R, Wei C, Linask K, Lo C. Connexin 43-mediated modulation of polarized cell movement and the directional migration of cardiac neural crest cells. Development. 2006;133:3629-39 pubmed
    b>Connexin 43 knockout (Cx43alpha1KO) mice have conotruncal heart defects that are associated with a reduction in the abundance of cardiac neural crest cells (CNCs) targeted to the heart...
  53. Shiojiri N, Sano M, Inujima S, Nitou M, Kanazawa M, Mori M. Quantitative analysis of cell allocation during liver development, using the spf(ash)-heterozygous female mouse. Am J Pathol. 2000;156:65-75 pubmed
  54. Davies T, Barr K, Jones D, Zhu D, Kidder G. Multiple members of the connexin gene family participate in preimplantation development of the mouse. Dev Genet. 1996;18:234-43 pubmed
    ..The expression of multiple connexin genes during this early period of embryogenesis (when there are only two distinct cell types) raises questions about the functional significance of connexin diversity in this context. ..
  55. Klein D, Groh J, Wettmarshausen J, Martini R. Nonuniform molecular features of myelinating Schwann cells in models for CMT1: distinct disease patterns are associated with NCAM and c-Jun upregulation. Glia. 2014;62:736-50 pubmed publisher
    We investigated three models for Charcot-Marie-Tooth type 1 (CMT1) neuropathy, comprising mice lacking connexin 32 (Cx32def), mice with reduced myelin protein zero (P0) expression (P0het) and transgenic mouse mutants overexpressing ..
  56. Wasseff S, Scherer S. Activated immune response in an inherited leukodystrophy disease caused by the loss of oligodendrocyte gap junctions. Neurobiol Dis. 2015;82:86-98 pubmed publisher
    ..junction (GJ) coupling is a widespread and essential feature of the CNS, and is mediated by connexin47 (Cx47) and Cx32. Loss of function mutations affecting Cx47 results in a severe leukodystrophy, Pelizeus-Merzbacher-like disease (..
  57. Valdimarsson G, De Sousa P, Kidder G. Coexpression of gap junction proteins in the cumulus-oocyte complex. Mol Reprod Dev. 1993;36:7-15 pubmed
    ..Transcripts of both connexin32 (Cx32) and connexin43 (Cx43) were detected by RT-PCR in both components of the COC...
  58. Hudder A, Werner R. Analysis of a Charcot-Marie-Tooth disease mutation reveals an essential internal ribosome entry site element in the connexin-32 gene. J Biol Chem. 2000;275:34586-91 pubmed
    ..A mutation in either of the first two elements investigated showed loss of IRES function, whereas mutation of a third element showed gain of function. ..
  59. Castiglioni B, Ferretti L, Tenchini M, Mezzelani A, Simonic T, Duga S. Physical mapping of connexin 32 (GJB1) and 43 (GJA1) genes to bovine chromosomes Xq22 and 9q15/16 by fluorescence in situ hybridization. Mamm Genome. 1996;7:634-5 pubmed
  60. Kobsar I, Maurer M, Ott T, Martini R. Macrophage-related demyelination in peripheral nerves of mice deficient in the gap junction protein connexin 32. Neurosci Lett. 2002;320:17-20 pubmed
    Mice deficient in the gap junction protein connexin 32 (Cx32) develop a slowly progressing demyelinating neuropathy, with enlarged periaxonal collars, abnormal non-compacted myelin domains and axonal sprouts...
  61. Valiunas V, Niessen H, Willecke K, Weingart R. Electrophysiological properties of gap junction channels in hepatocytes isolated from connexin32-deficient and wild-type mice. Pflugers Arch. 1999;437:846-56 pubmed
    Hepatocytes were isolated from wild-type and connexin32-deficient (Cx32-deficient) mice. Pairs of cells were chosen to study the electrical properties of gap junction channels using the dual voltage-clamp method...
  62. Lynn B, Tress O, May D, Willecke K, Nagy J. Ablation of connexin30 in transgenic mice alters expression patterns of connexin26 and connexin32 in glial cells and leptomeninges. Eur J Neurosci. 2011;34:1783-93 pubmed publisher
    Expression of connexin26 (Cx26), Cx30 and Cx43 in astrocytes and expression of Cx29, Cx32 and Cx47 in oligodendrocytes of adult rodent brain has been well documented, as has the interdependence of connexin expression patterns of ..
  63. Sutor B, Schmolke C, Teubner B, Schirmer C, Willecke K. Myelination defects and neuronal hyperexcitability in the neocortex of connexin 32-deficient mice. Cereb Cortex. 2000;10:684-97 pubmed
    Morphological and electrophysiological studies were performed on neocortices of adult Connexin 32 (Cx32)-deficient mice and wild-type mice to investigate the consequences of a lack of the gap junction subunit Cx32 on neocortical ..
  64. Dagli M, Yamasaki H, Krutovskikh V, Omori Y. Delayed liver regeneration and increased susceptibility to chemical hepatocarcinogenesis in transgenic mice expressing a dominant-negative mutant of connexin32 only in the liver. Carcinogenesis. 2004;25:483-92 pubmed
    ..double transfection experiments on HeLa cells have shown that a dominant-negative mutant V139 M of connexin32 (Cx32) can abolish gap junctional intercellular communication (GJIC)...
  65. Sainio K, Gilbert S, Lehtonen E, Nishi M, Kumar N, Gilula N, et al. Differential expression of gap junction mRNAs and proteins in the developing murine kidney and in experimentally induced nephric mesenchymes. Development. 1992;115:827-37 pubmed
    The expression of three gap junction (GJ) proteins, alpha 1 (Cx43), beta 1 (Cx32), and beta 2 (Cx26), and their transcripts were examined during the ontogeny of the mouse and rat kidney...
  66. Stutenkemper R, Geisse S, Schwarz H, Look J, Traub O, Nicholson B, et al. The hepatocyte-specific phenotype of murine liver cells correlates with high expression of connexin32 and connexin26 but very low expression of connexin43. Exp Cell Res. 1992;201:43-54 pubmed
    ..Furthermore several dedifferentiated cell lines derived from rat or mouse liver and cultivated in serum-containing medium were found to express little connexin32 or connexin26 mRNA but relatively high levels of connexin43 mRNA. ..
  67. Melanson Drapeau L, Beyko S, Davé S, Hebb A, Franks D, Sellitto C, et al. Oligodendrocyte progenitor enrichment in the connexin32 null-mutant mouse. J Neurosci. 2003;23:1759-68 pubmed
  68. Avraham K, Cho B, Gilbert D, Fujii H, Okamoto K, Shimazaki T, et al. Murine chromosomal location of four class III POU transcription factors. Genomics. 1993;18:131-3 pubmed
    ..Chromosomal mapping has demonstrated that the four genes are unlinked: Otf-6 is located on the distal region of chromosome 4, Otf-7 on the proximal region of chromosome 4, Otf-8 on chromosome 1, and Otf-9 on the X chromosome. ..
  69. Gershon E, Plaks V, Aharon I, Galiani D, Reizel Y, Sela Abramovich S, et al. Oocyte-directed depletion of connexin43 using the Cre-LoxP system leads to subfertility in female mice. Dev Biol. 2008;313:1-12 pubmed
  70. Borsani G, Tonlorenzi R, Simmler M, Dandolo L, Arnaud D, Capra V, et al. Characterization of a murine gene expressed from the inactive X chromosome. Nature. 1991;351:325-9 pubmed
    ..Nucleotide sequence analysis indicates that Xist may be associated with a protein product. The similar map positions and expression patterns for Xist in mouse and man suggest that this gene may have a role in X inactivation. ..
  71. Lopez Bigas N, Arbones M, Estivill X, Simonneau L. Expression profiles of the connexin genes, Gjb1 and Gjb3, in the developing mouse cochlea. Gene Expr Patterns. 2002;2:113-7 pubmed
    ..of the connexins in the inner ear we have analyzed the gene expression profiles of two connexin genes, Gjb1 (connexin 32) and Gjb3 (connexin 31), by in situ hybridization during the mouse cochlea organogenesis, from early otocyst up ..
  72. Tang W, Zhang Y, Chang Q, Ahmad S, Dahlke I, Yi H, et al. Connexin29 is highly expressed in cochlear Schwann cells, and it is required for the normal development and function of the auditory nerve of mice. J Neurosci. 2006;26:1991-9 pubmed
    ..Our findings demonstrated the requirement of Cx29 for normal cochlear functions and suggest that Cx29 is a new candidate gene for studying the auditory neuropathy. ..
  73. Mones S, Bordignon B, Peiretti F, Landrier J, Gess B, Bourguignon J, et al. CamKII inhibitors reduce mitotic instability, connexon anomalies and progression of the in vivo behavioral phenotype in transgenic animals expressing a mutated Gjb1 gene. Front Neurosci. 2014;8:151 pubmed publisher
    Mutation in the Gjb1 gene, coding for a connexin (Cx32), is associated with an inherited peripheral neuropathic disorder (X-linked Charcot-Marie-Tooth, CMTX)...
  74. Temme A, Ott T, Haberberger T, Traub O, Willecke K. Acute-phase response and circadian expression of connexin26 are not altered in connexin32-deficient mouse liver. Cell Tissue Res. 2000;300:111-7 pubmed
    In mouse hepatocytes, the gap junctional proteins connexin32 (Cx32) and connexin26 (Cx26) are expressed in the same gap junctional plaque. Expression of the major Cx32 protein is downregulated during liver regeneration and cholestasis...
  75. Fröb F, Bremer M, Finzsch M, Kichko T, Reeh P, Tamm E, et al. Establishment of myelinating Schwann cells and barrier integrity between central and peripheral nervous systems depend on Sox10. Glia. 2012;60:806-19 pubmed publisher
    ..We infer that in addition to its many roles in Schwann cells, Sox10 is also important for the integrity of the boundary between central and peripheral nervous systems. ..
  76. Frossard J, Rubbia Brandt L, Wallig M, Benathan M, Ott T, Morel P, et al. Severe acute pancreatitis and reduced acinar cell apoptosis in the exocrine pancreas of mice deficient for the Cx32 gene. Gastroenterology. 2003;124:481-93 pubmed
    ..to injury, we analyzed the course of acute pancreatitis induced by injection of cerulein in mice deficient for Cx32, the major gap junction protein expressed in the exocrine pancreas...
  77. Evert M, Ott T, Temme A, Willecke K, Dombrowski F. Morphology and morphometric investigation of hepatocellular preneoplastic lesions and neoplasms in connexin32-deficient mice. Carcinogenesis. 2002;23:697-703 pubmed
    ..and the formation of preneoplastic foci and hepatocellular neoplasms in transgenic knockout mice, as Connexin32 (Cx32) is the major gap junction protein in the liver...
  78. Charollais A, Serre V, Mock C, Cogne F, Bosco D, Meda P. Loss of alpha 1 connexin does not alter the prenatal differentiation of pancreatic beta cells and leads to the identification of another islet cell connexin. Dev Genet. 1999;24:13-26 pubmed
    ..They further provide evidence that normal and tumoral insulin-producing cells natively coexpress connexins alpha 1 and alpha 6. ..
  79. De Backer O, Verheyden A, Martin B, Godelaine D, De Plaen E, Brasseur R, et al. Structure, chromosomal location, and expression pattern of three mouse genes homologous to the human MAGE genes. Genomics. 1995;28:74-83 pubmed
    ..Smage1/2 transcripts were detected in several tumor and embryonal cell lines but not in normal mouse tissues with the exception of testis. Expression of Smage3 was found in embryos from Day 11 to Day 15. ..
  80. Degen J, Schütz M, Dicke N, Strenzke N, Jokwitz M, Moser T, et al. Connexin32 can restore hearing in connexin26 deficient mice. Eur J Cell Biol. 2011;90:817-24 pubmed publisher
    ..Here we have studied the functional equivalence of Cx26 and connexin32 (Cx32) isoforms in the cochlea...
  81. Hirabayashi Y, Yoon B, Tsuboi I, Huo Y, Kodama Y, Kanno J, et al. Protective role of connexin 32 in steady-state hematopoiesis, regeneration state, and leukemogenesis. Exp Biol Med (Maywood). 2007;232:700-12 pubmed
    ..Primitive hematopoietic progenitor cells form a multicellular system, but a previous report states that Cx32 is not expressed in the bone marrow...
  82. Park W, Park J, Erez Roman R, Kogot Levin A, Bame J, Tirosh B, et al. Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalization. J Biol Chem. 2013;288:30904-16 pubmed publisher
    ..All of these drugs and chemicals require connexin (Cx) 32, a key gap junction protein, to induce hepatotoxicity. Cx32 was mislocalized to an intracellular location in hepatocytes from CerS2 null mice, which resulted in accelerated ..
  83. Cooper P, Keer J, McCabe V, Hamvas R, Brown S, Rastan S, et al. Physical mapping of 2000 kb of the mouse X chromosome in the vicinity of the Xist locus. Genomics. 1993;15:570-5 pubmed
    ..The DXCrc177 and DXCrc318 loci, both defined by probes derived from linking clones, are associated with CpG-rich islands. The map provides a framework for the isolation of underlying sequences in the mouse X-inactivation center region. ..
  84. Pantano S, Zonta F, Mammano F. A fully atomistic model of the Cx32 connexon. PLoS ONE. 2008;3:e2614 pubmed publisher
    ..We then produced a fully atomistic model of a homotypic Cx32 connexon starting from a published model of the C alpha carbons arrangement for the connexin transmembrane helices, ..