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Genomes and Genes
| Gja3SummaryGene Symbol: Gja3 Description: gap junction protein, alpha 3 Alias: Cnx46, Cx43, Cx46, Gja-3, alpha 3 connexin, connexin-46, gap junction alpha-3 protein, gap junction membrane channel protein alpha 3 Species: mouse Top Publications
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Publications
Genetic factors influence cataract formation in alpha 3 connexin knockout miceX Gong
Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037, USA
Dev Genet 24:27-32. 1999Connexin alpha 3 (Cx46 or Gja3) gene targeted null mice developed lens nuclear cataracts shortly after birth. A large variance in the cataracts was observed in alpha 3 null sibs on a mixed 129SvJae X C57BL/6J F3 background...
Gap junctional coupling in lenses lacking alpha3 connexinX Gong
Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 95:15303-8. 1998Fiber cells of the lens are interconnected by an extensive network of gap junctions containing alpha3 (Cx46) and alpha8 (Cx50) connexins. A specific role for these connexins in lens homeostasis is not known...- Unique and redundant connexin contributions to lens developmentThomas W White
Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
Science 295:319-20. 2002..Knockout of Cx46 causes a loss of homeostasis and cataracts. Deletion of Cx50 results in reduced ocular growth and cataracts... - Defining a link between gap junction communication, proteolysis, and cataract formationA Baruch
Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA
J Biol Chem 276:28999-9006. 2001Disruption of the connexin alpha 3 (Cx46) gene (alpha 3 (-/-)) in mice results in severe cataracts within the nuclear portion of the lens... - Genetic diseases and gene knockouts reveal diverse connexin functionsT W White
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Annu Rev Physiol 61:283-310. 1999..In addition, gene targeting of connexins in mice has provided new insights into connexin function and the significance of connexin diversity... - Dominant cataracts result from incongruous mixing of wild-type lens connexinsFrancisco J Martinez-Wittinghan
Department of Physiology and Biophysics, State University of New York, Stony Brook 11794, USA
J Cell Biol 161:969-78. 2003..In the lens, Cx46 and Cx50 provide the gap junctional coupling needed for homeostasis and growth... - Disruption of alpha3 connexin gene leads to proteolysis and cataractogenesis in miceX Gong
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Cell 91:833-43. 1997Gap junction channels formed by alpha3 (Cx46) and alpha8 (Cx50) connexin provide pathways for communication between the fiber cells in the normal transparent lens... - Age-related cataracts in alpha3Cx46-knockout mice are dependent on a calpain 3 isoformYajun Tang
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Invest Ophthalmol Vis Sci 48:2685-94. 2007..In the present study, a more in vivo-relevant model was generated to test the hypothesis that the calpain 3 gene is involved in age-related nuclear cataractogenesis in alpha3Cx46 knockout mice... - Diverse functions of vertebrate gap junctionsA M Simon
Dept of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
Trends Cell Biol 8:477-83. 1998.... - Structural and immunocytochemical alterations in eye lens fiber cells from Cx46 and Cx50 knockout miceIrene Dunia
Biologie Cellulaire, Institut Jacques Monod, CNRS, Universités Paris 6 Paris 7, 2, place Jussieu, F 75251 Paris Cedex 5, France
Eur J Cell Biol 85:729-52. 2006In the current study we describe the changes of overall organization of lens fiber cells in connexin 46 (Cx46) and connexin 50 (Cx50) knockout mice... - mRNA expression pattern of multiple members of connexin gene family in normal and abnormal fetal gonads in mouseSubhash C Juneja
Department of Zoology, The University of Western Ontario, London, Canada
Indian J Physiol Pharmacol 47:147-56. 2003..The mRNA expression pattern of connexins (Cx26, Cx30.3, Cx31, Cx31.1, Cx32, Cx37, Cx40, Cx43, Cx45, Cx46 and Cx50) was analyzed by RT-PCR... - Connections between connexins, calcium, and cataracts in the lensJunyuan Gao
Department of Physiology and Biophysics, State University of New York at Stony Brook, NY 11794, USA
J Gen Physiol 124:289-300. 2004..of the present study was to test this calcium circulation hypothesis by studying calcium homeostasis in connexin (Cx46) knockout and (Cx46 for Cx50) knockin mouse lenses, which have different degrees of gap junction coupling... - The novel mouse connexin39 gene is expressed in developing striated muscle fibersJulia von Maltzahn
Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, Römerstr 164, 53117 Bonn, Germany
J Cell Sci 117:5381-92. 2004..As expression of no other known connexin could be verified in these cells, intercellular dye transfer might result from functional expression of Cx39 in developing striated muscle fibers... - Variable promoter usage and alternative splicing in five mouse connexin genesCurtis L Anderson
Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, P O Box 016129, Miami, FL 33136, USA
Genomics 85:238-44. 2005..cDNA targeting five candidate genes, Cx31, Cx40, Cx45, Cx46, and Cx47 (approved gene symbols Gjb3, Gja5, Gja7, Gja3, and Gja12, respectively), revealed the existence of multiple previously unknown exons upstream of the coding .. - Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesisChun hong Xia
School of Optometry and Vision Science Program, University of California at Berkeley, Berkeley, CA 94720, USA
Development 133:2033-40. 2006Different mutations of alpha3 connexin (Cx46 or Gja8) and alpha8 connexin (Cx50 or Gja8), subunits of lens gap junction channels, cause a variety of cataracts via unknown mechanisms... - Cardiac conduction is required to preserve cardiac chamber morphologyNeil C Chi
Departments of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 107:14662-7. 2010..By positional cloning, we found that dco encodes Gja3/Cx46, a gap junction protein not previously implicated in heart formation or function... - Functional analysis of hemichannels and gap-junctional channels formed by connexins 43 and 46Quan V Hoang
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
Mol Vis 16:1343-52. 2010..Retinal pigment epithelium (RPE) cells express Cx43 and Cx46. Here, we employed a heterologous expression system to explore the functional properties of the hemichannels and .. - Knock-in of alpha3 connexin prevents severe cataracts caused by an alpha8 point mutationChun hong Xia
School of Optometry and Vision Science Program, University of California at Berkeley, Berkeley, CA, USA
J Cell Sci 119:2138-44. 2006..has been previously shown to cause a severe cataract by interacting with endogenous wild-type alpha3 connexin (Cx46) in mouse lenses... - Global gene expression analysis of lenses from different mouse strains and in the alpha3Cx46 knockout mouseYajun Tang
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA
Mol Vis 16:113-21. 2010Disruption of the mouse gene encoding the gap junction subunit alpha3 connexin 46 (alpha3Cx46) results in the formation of lens cataracts that have a severity affected by the genetic background of the mouse strain... - Gap junction communication influences intercellular protein distribution in the lensCatherine Cheng
UC Berkeley UCSF Joint Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, CA, USA
Exp Eye Res 86:966-74. 2008..Although the mechanism that drives GFP transport between fiber cells remains unknown, this work reveals that gap junction communication plays a novel role in the regulation of intercellular protein distribution in the lens... - Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cellsChun hong Xia
School of Optometry and Vision Science Program, University of California at Berkeley, 693 Minor Hall, Berkeley, CA 94720 2020, USA
Exp Eye Res 83:688-96. 2006..and transparency have been hypothesized to depend on intercellular gap junction channels, consisting of alpha3 (Cx46) and alpha8 (Cx50) connexin subunits, to transport metabolites, secondary messages and ions between lens cells... - An expression atlas of connexin genes in the mouseAnnalisa Buniello
Telethon Institute of Genetics and Medicine, Via P Castellino 111, 80131 Naples, Italy
Genomics 83:812-20. 2004.... - An update on connexin genes and their nomenclature in mouse and manGoran Sohl
Institut fur Genetik, Universitat Bonn, Germany
Cell Commun Adhes 10:173-80. 2003..Furthermore, this short review contains an update on phenotypic correlations between connexin deficient mice and patients bearing mutations in their orthologous connexin genes... - Gap junctions in the inner ear: comparison of distribution patterns in different vertebrates and assessement of connexin composition in mammalsAndrew Forge
UCL Centre for Auditory Research and Institute of Laryngology and Otology, University College London, London WC1X 8EE, United Kingdom
J Comp Neurol 467:207-31. 2003..ear by RT-PCR, Western blotting, and immunohistochemistry revealed four connexin isotypes, cx26, cx30, cx31, and cx43, in the cochlea and three, cx26, cx30, and cx43, in the vestibular organs... - Distribution of genes for gap junction membrane channel proteins on human and mouse chromosomesC L Hsieh
Howard Hughes Medical Institute, Stanford, California
Somat Cell Mol Genet 17:191-200. 1991..1-q24.1; GJB1 (connexin32) to Xcen-q22; GJB2 (connexin26) to 13; and GJA3 (connexin46) also to 13, probably near GJB2... - Multiple members of the connexin gene family participate in preimplantation development of the mouseT C Davies
Department of Zoology, University of Western Ontario, London, Canada
Dev Genet 18:234-43. 1996..They can be divided into two groups with respect to the timing of mRNA accumulation: Cx31, Cx43, and Cx45 mRNAs accumulate continuously from the two- or four-cell stage, whereas Cx30.3, Cx31... - bcl-w, a novel member of the bcl-2 family, promotes cell survivalL Gibson
Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, Australia
Oncogene 13:665-75. 1996..These findings suggest that bcl-w participates in the control of apoptosis in multiple cell types. Its functional similarity to bcl-2 also makes it an attractive candidate proto-oncogene... - Physical mapping confirms that sheep chromosome 10 has extensive conserved synteny with cattle chromosome 12 and human chromosome 13T E Broad
Department of Biochemistry, University of Otago, Dunedin, New Zealand
Anim Genet 27:249-53. 1996..cell hybrids: gap junction protein, beta 2, 26 kDa (connexin 26) (GJB2); gap junction protein, alpha 3, 46 kDa (connexin 46) (GJA3), and esterase D/formylglutathione hydrolase (ESD)... - Assignment of connexin 26 (GJB2) and 46 (GJA3) genes to human chromosome 13q11-->q12 and mouse chromosome 14D1-E1 by in situ hybridizationC Mignon
INSERM U. 406, , Marseille
Cytogenet Cell Genet 72:185-6. 1996 - Genes, gene knockouts, and mutations in the analysis of gap junctionsC W Lo
Department of Biology, University of Pennsylvania, Philadelphia 19104 6017, USA
Dev Genet 24:1-4. 1999..It may be timely to form a Nomenclature Committee to establish a uniform classification scheme for naming gap junction proteins... - Role of connexin (gap junction) genes in cell growth control and carcinogenesisH Yamasaki
Unit of Multistage Carcinogenesis, International Agency for Research on Cancer, Lyon, France
C R Acad Sci III 322:151-9. 1999..We have produced various dominant-negative mutants of Cx26, Cx32 and Cx43 and showed that some of them prevent the growth control exerted by the corresponding wild-type genes... - A Gja8 (Cx50) point mutation causes an alteration of alpha 3 connexin (Cx46) in semi-dominant cataracts of Lop10 miceBo Chang
The Jackson Laboratory, Bar Harbor, ME, USA
Hum Mol Genet 11:507-13. 2002..loss-of-function mutant for alpha 8, as well as a dominant mutation for reducing the phosphorylated forms of alpha 3 connexin in vivo... - Functional significance of gap junctional coupling in preimplantation developmentF D Houghton
Department of Physiology, Dental Sciences Building, The University of Western Ontario, London, Ontario, Canada N6A 5C1
Biol Reprod 66:1403-12. 2002..New evidence of this diversification is presented using rat blastocyst outgrowths... - Transient decrease in gap junction expression during compensatory renal growth in miceShengwen Li
Department of Urology, Nagasaki University School of Medicine, Nagasaki, Japan
Urology 60:726-30. 2002..Gap junctional intercellular communication plays important roles in homeostatic regulation, differentiation, and synchronization of cellular electronic and metabolic functions... - Chromosomal assignments of mouse connexin genes, coding for gap junctional proteins, by somatic cell hybridizationH J Schwarz
Institut fur Genetik, Abt Molekulargenetik, Universitat Bonn, Germany
Somat Cell Mol Genet 18:351-9. 1992..In addition, our results confirm the recent assignment of mouse connexin genes Cx26, Cx32, Cx37, Cx40, Cx43, and Cx46 to mouse chromosomes 14, X, 4, 3, 10, and 14, respectively, by analysis of interspecific backcrosses and by somatic .. - Lens connexins alpha3Cx46 and alpha8Cx50 interact with zonula occludens protein-1 (ZO-1)Peter A Nielsen
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Mol Biol Cell 14:2470-81. 2003..The spatial variation in the interaction of ZO-1 with lens gap junctions is intriguing and is suggestive of multiple dynamic roles for this association... - Properties of connexin 46 hemichannels in dissociated lens fiber cellsLisa Ebihara
Departments of Physiology and Biophysics, Rosalind Franklin School of Medicine and Science, North Chicago, Illinois 60064, USA
Invest Ophthalmol Vis Sci 52:882-9. 2011To characterize the properties of connexin 46 hemichannels in differentiating fiber cells isolated from mouse lenses. - Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mappingJ A Haefliger
Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115
J Biol Chem 267:2057-64. 1992..Cx40, Cx37, and Cx33 are similar to the previously characterized Cx43 and Cx46. Cx31.1 is similar to Cx26, Cx31, and Cx32...
Research Grants
- INTERCELLULAR COMMUNICATION IN THE LENSLisa Ebihara; Fiscal Year: 2010..Three different connexin proteins (Connexin 43 (Cx43), Connexin 46 (Cx46), Connexin 50 (Cx50)) have been identified in lens fibers...
- INTERCELLULAR COMMUNICATION IN THE LENSLisa Ebihara; Fiscal Year: 2009..Three different connexin proteins (Connexin 43 (Cx43), Connexin 46 (Cx46), Connexin 50 (Cx50)) have been identified in lens fibers...
- INTERCELLULAR COMMUNICATION IN THE LENSLisa Ebihara; Fiscal Year: 2006..Two different gap junctional proteins, Connexin 46 (Cx48) and Connexin 50 (Cx50), have been identified in lens fiber cells...
- INTERCELLULAR COMMUNICATION IN THE LENSLisa Ebihara; Fiscal Year: 2001DESCRIPTION: Specific Aim #1: The PI will compare single channel properties of Cx46 and Cx56 hemichannels and their regulation by Ca++, protons and phosphorylation. Goals will be to see if Cx46 and Cx50 (or Cx56 and Cx45...
- INTERCELLULAR COMMUNICATION IN THE LENSLisa Ebihara; Fiscal Year: 2011..Three different connexin proteins (Connexin 43 (Cx43), Connexin 46 (Cx46), Connexin 50 (Cx50)) have been identified in lens fibers...