Gja1

Summary

Gene Symbol: Gja1
Description: gap junction protein, alpha 1
Alias: AU042049, AW546267, Cnx43, Cx43, Cx43alpha1, Gja-1, Npm1, connexin43, gap junction alpha-1 protein, alpha 1 connexin, connexin-43, gap junction 43 kDa heart protein, gap junction membrane channel protein alpha 1
Species: mouse
Products:     Gja1

Top Publications

  1. Rhee D, Zhao X, Francis R, Huang G, Mably J, Lo C. Connexin 43 regulates epicardial cell polarity and migration in coronary vascular development. Development. 2009;136:3185-93 pubmed publisher
    b>Connexin 43 knockout (Cx43 KO) mice exhibit conotruncal malformations and coronary artery defects...
  2. Boogerd K, Wong L, Christoffels V, Klarenbeek M, Ruijter J, Moorman A, et al. Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43. Cardiovasc Res. 2008;78:485-93 pubmed publisher
    ..They regulate the gap-junction-encoding gene Connexin43 (Cx43) and other genes critical for heart development and function...
  3. Lloyd S, Loiselle A, Zhang Y, Donahue H. Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling. Bone. 2013;57:76-83 pubmed publisher
    b>Connexin 43 (Cx43) is a gap junction protein that plays an integral role in the skeletal response to mechanical loading and unloading...
  4. Eltzschig H, Eckle T, Mager A, Küper N, Karcher C, Weissmüller T, et al. ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ Res. 2006;99:1100-8 pubmed
    ..These studies showed that PMN ATP release occurs through connexin 43 (Cx43) hemichannels in a protein/phosphatase-A-dependent manner...
  5. Dobrowolski R, Hertig G, Lechner H, Wörsdörfer P, Wulf V, Dicke N, et al. Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice. Hum Mol Genet. 2009;18:2899-911 pubmed publisher
    Mutations in the GJA1 gene coding for connexin43 (Cx43) cause oculodentodigital dysplasia (ODDD), a pleiotropic human disorder with characteristic morphologic anomalies of face, teeth, bones and digits...
  6. Ableser M, Penuela S, Lee J, Shao Q, Laird D. Connexin43 reduces melanoma growth within a keratinocyte microenvironment and during tumorigenesis in vivo. J Biol Chem. 2014;289:1592-603 pubmed publisher
    ..Here, we show that the aggressive B16-BL6 mouse melanoma cell line expresses low basal levels of Cx26 and Cx43, rendering them gap junctional intercellular communication-deficient as elucidated by immunofluorescence, Western ..
  7. Lin J, Lou N, Kang N, Takano T, Hu F, Han X, et al. A central role of connexin 43 in hypoxic preconditioning. J Neurosci. 2008;28:681-95 pubmed publisher
    ..Here we show that connexin 43 (Cx43) plays a key role in protection afforded by preconditioning...
  8. Gosejacob D, Dublin P, Bedner P, Hüttmann K, Zhang J, Tress O, et al. Role of astroglial connexin30 in hippocampal gap junction coupling. Glia. 2011;59:511-9 pubmed publisher
    ..In contrast, mice lacking connexin43 (Cx43) in astrocytes exhibited only 50% reduction in coupling...
  9. Sridharan S, Simon L, Meling D, Cyr D, Gutstein D, Fishman G, et al. Proliferation of adult sertoli cells following conditional knockout of the Gap junctional protein GJA1 (connexin 43) in mice. Biol Reprod. 2007;76:804-12 pubmed
    GJA1 (also known and referred to here as connexin 43 and abbreviated CX43) is the predominant testicular gap junction protein, and CX43 may regulate Sertoli cell maturation and spermatogenesis...
  10. Scemes E. Modulation of astrocyte P2Y1 receptors by the carboxyl terminal domain of the gap junction protein Cx43. Glia. 2008;56:145-53 pubmed
    ..We have previously shown that deletion of the astrocytic gap junction protein, connexin43 (Cx43) causes a right-ward shift in the dose-response curve to P2Y1R agonists and decreased P2Y1R expression ..

Detail Information

Publications82

  1. Rhee D, Zhao X, Francis R, Huang G, Mably J, Lo C. Connexin 43 regulates epicardial cell polarity and migration in coronary vascular development. Development. 2009;136:3185-93 pubmed publisher
    b>Connexin 43 knockout (Cx43 KO) mice exhibit conotruncal malformations and coronary artery defects...
  2. Boogerd K, Wong L, Christoffels V, Klarenbeek M, Ruijter J, Moorman A, et al. Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43. Cardiovasc Res. 2008;78:485-93 pubmed publisher
    ..They regulate the gap-junction-encoding gene Connexin43 (Cx43) and other genes critical for heart development and function...
  3. Lloyd S, Loiselle A, Zhang Y, Donahue H. Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling. Bone. 2013;57:76-83 pubmed publisher
    b>Connexin 43 (Cx43) is a gap junction protein that plays an integral role in the skeletal response to mechanical loading and unloading...
  4. Eltzschig H, Eckle T, Mager A, Küper N, Karcher C, Weissmüller T, et al. ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function. Circ Res. 2006;99:1100-8 pubmed
    ..These studies showed that PMN ATP release occurs through connexin 43 (Cx43) hemichannels in a protein/phosphatase-A-dependent manner...
  5. Dobrowolski R, Hertig G, Lechner H, Wörsdörfer P, Wulf V, Dicke N, et al. Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice. Hum Mol Genet. 2009;18:2899-911 pubmed publisher
    Mutations in the GJA1 gene coding for connexin43 (Cx43) cause oculodentodigital dysplasia (ODDD), a pleiotropic human disorder with characteristic morphologic anomalies of face, teeth, bones and digits...
  6. Ableser M, Penuela S, Lee J, Shao Q, Laird D. Connexin43 reduces melanoma growth within a keratinocyte microenvironment and during tumorigenesis in vivo. J Biol Chem. 2014;289:1592-603 pubmed publisher
    ..Here, we show that the aggressive B16-BL6 mouse melanoma cell line expresses low basal levels of Cx26 and Cx43, rendering them gap junctional intercellular communication-deficient as elucidated by immunofluorescence, Western ..
  7. Lin J, Lou N, Kang N, Takano T, Hu F, Han X, et al. A central role of connexin 43 in hypoxic preconditioning. J Neurosci. 2008;28:681-95 pubmed publisher
    ..Here we show that connexin 43 (Cx43) plays a key role in protection afforded by preconditioning...
  8. Gosejacob D, Dublin P, Bedner P, Hüttmann K, Zhang J, Tress O, et al. Role of astroglial connexin30 in hippocampal gap junction coupling. Glia. 2011;59:511-9 pubmed publisher
    ..In contrast, mice lacking connexin43 (Cx43) in astrocytes exhibited only 50% reduction in coupling...
  9. Sridharan S, Simon L, Meling D, Cyr D, Gutstein D, Fishman G, et al. Proliferation of adult sertoli cells following conditional knockout of the Gap junctional protein GJA1 (connexin 43) in mice. Biol Reprod. 2007;76:804-12 pubmed
    GJA1 (also known and referred to here as connexin 43 and abbreviated CX43) is the predominant testicular gap junction protein, and CX43 may regulate Sertoli cell maturation and spermatogenesis...
  10. Scemes E. Modulation of astrocyte P2Y1 receptors by the carboxyl terminal domain of the gap junction protein Cx43. Glia. 2008;56:145-53 pubmed
    ..We have previously shown that deletion of the astrocytic gap junction protein, connexin43 (Cx43) causes a right-ward shift in the dose-response curve to P2Y1R agonists and decreased P2Y1R expression ..
  11. Thi M, Islam S, Suadicani S, Spray D. Connexin43 and pannexin1 channels in osteoblasts: who is the "hemichannel"?. J Membr Biol. 2012;245:401-9 pubmed publisher
    ..Unapposed gap junction hemichannels formed of connexin43 (Cx43) have been proposed as a major route for such exchange, in particular for release of ATP and prostaglandin ..
  12. Pannasch U, Vargova L, Reingruber J, Ezan P, Holcman D, Giaume C, et al. Astroglial networks scale synaptic activity and plasticity. Proc Natl Acad Sci U S A. 2011;108:8467-72 pubmed publisher
    ..Although the gap junction proteins connexin 30 (Cx30) and connexin 43 (Cx43) mediate the extensive network organization of astrocytes, their role in synaptic physiology is unknown...
  13. Figiel M, Allritz C, Lehmann C, Engele J. Gap junctional control of glial glutamate transporter expression. Mol Cell Neurosci. 2007;35:130-7 pubmed
    ..Here, we show that uncoupling cultured cortical astrocytes with the gap junction blocker, propofol, or the Cx43 mimetic peptide, Gap27, inhibits the expression of GLT-1, the major glutamate transporter subtype in the cortex...
  14. Loiselle A, Paul E, Lewis G, Donahue H. Osteoblast and osteocyte-specific loss of Connexin43 results in delayed bone formation and healing during murine fracture healing. J Orthop Res. 2013;31:147-54 pubmed publisher
    b>Connexin43 (Cx43) plays an important role in osteoblastic differentiation in vitro, and bone formation in vivo...
  15. Carette D, Weider K, Gilleron J, Giese S, Dompierre J, Bergmann M, et al. Major involvement of connexin 43 in seminiferous epithelial junction dynamics and male fertility. Dev Biol. 2010;346:54-67 pubmed publisher
    ..We have here investigated the role of Cx43 in the control of adherens and tight junction proteins (N-cadherin, beta-catenin, occludin and ZO-1) by using ..
  16. Squecco R, Sassoli C, Nuti F, Martinesi M, Chellini F, Nosi D, et al. Sphingosine 1-phosphate induces myoblast differentiation through Cx43 protein expression: a role for a gap junction-dependent and -independent function. Mol Biol Cell. 2006;17:4896-910 pubmed
    ..Indeed, the treatment with S1P greatly enhanced Cx43 expression and gap junctional intercellular communication during the early phases of myoblast differentiation, ..
  17. Stein M, van Veen T, Remme C, Boulaksil M, Noorman M, van Stuijvenberg L, et al. Combined reduction of intercellular coupling and membrane excitability differentially affects transverse and longitudinal cardiac conduction. Cardiovasc Res. 2009;83:52-60 pubmed publisher
    ..b>Connexin43 (Cx43) and sodium channel Nav1...
  18. Thi M, Urban Maldonado M, Spray D, Suadicani S. Characterization of hTERT-immortalized osteoblast cell lines generated from wild-type and connexin43-null mouse calvaria. Am J Physiol Cell Physiol. 2010;299:C994-C1006 pubmed publisher
    The gap junction protein connexin43 (Cx43) has been proposed to play key roles in bone differentiation and mineralization, but underlying cellular mechanisms are not totally understood...
  19. Toth K, Shao Q, Lorentz R, Laird D. Decreased levels of Cx43 gap junctions result in ameloblast dysregulation and enamel hypoplasia in Gja1Jrt/+ mice. J Cell Physiol. 2010;223:601-9 pubmed publisher
    ..To assess the role of Cx43 in tooth development we employ a mouse model of ODDD that harbors a G60S Cx43 mutant, Gja1(Jrt)/+, and appears to exhibit tooth abnormalities that mimic the human disease...
  20. Chung D, Castro C, Watkins M, Stains J, Chung M, Szejnfeld V, et al. Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43. J Cell Sci. 2006;119:4187-98 pubmed
    b>Connexin43 (Cx43) is involved in bone development, but its role in adult bone homeostasis remains unknown...
  21. Rouach N, Koulakoff A, Abudara V, Willecke K, Giaume C. Astroglial metabolic networks sustain hippocampal synaptic transmission. Science. 2008;322:1551-5 pubmed publisher
    ..Here, we show that the gap-junction subunit proteins connexin 43 and 30 allow intercellular trafficking of glucose and its metabolites through astroglial networks...
  22. Lu G, Haider H, Jiang S, Ashraf M. Sca-1+ stem cell survival and engraftment in the infarcted heart: dual role for preconditioning-induced connexin-43. Circulation. 2009;119:2587-96 pubmed publisher
    ..3+/-2.1; P=0.03) were improved in group 3 compared with group 2. Preconditioning with IGF-1 reprograms Sca-1+ for prosurvival signaling and cardiomyogenic differentiation with an important role for Cx-43 in this process. ..
  23. Cotrina M, Lin J, Nedergaard M. Adhesive properties of connexin hemichannels. Glia. 2008;56:1791-8 pubmed publisher
    ..We have also found that high expression of Cx43, but not Cx32 hemichannels, can drive adhesion of cells expressing low levels of Cx43...
  24. Bierhuizen M, Boulaksil M, van Stuijvenberg L, van der Nagel R, Jansen A, Mutsaers N, et al. In calcineurin-induced cardiac hypertrophy expression of Nav1.5, Cx40 and Cx43 is reduced by different mechanisms. J Mol Cell Cardiol. 2008;45:373-84 pubmed publisher
    Alterations in expression levels of Na(v)1.5, Cx43 and Cx40 have been frequently reported in cardiac disease and are associated with the development of arrhythmias, but little is known about the underlying molecular mechanisms...
  25. Bivi N, Lezcano V, Romanello M, Bellido T, Plotkin L. Connexin43 interacts with ?arrestin: a pre-requisite for osteoblast survival induced by parathyroid hormone. J Cell Biochem. 2011;112:2920-30 pubmed publisher
    ..We present evidence herein that PTH-induced survival signaling is impaired in cells lacking connexin43 (Cx43)...
  26. Kunze A, Congreso M, Hartmann C, Wallraff Beck A, Hüttmann K, Bedner P, et al. Connexin expression by radial glia-like cells is required for neurogenesis in the adult dentate gyrus. Proc Natl Acad Sci U S A. 2009;106:11336-41 pubmed publisher
    ..We show that a majority of Radial glia-like cells are coupled and express Cx43. Neuronal precursors were not coupled...
  27. Domínguez J, de la Rosa A, Navarro F, Franco D, Aranega A. Tissue distribution and subcellular localization of the cardiac sodium channel during mouse heart development. Cardiovasc Res. 2008;78:45-52 pubmed publisher
    ..5, shows a dynamic expression pattern during mouse heart development, indicating that it could play an important role in the acquisition of a mature pattern of conduction and contraction during cardiogenesis. ..
  28. Wallraff A, Köhling R, Heinemann U, Theis M, Willecke K, Steinhäuser C. The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus. J Neurosci. 2006;26:5438-47 pubmed
    ..We obtained mice with coupling-deficient astrocytes by crossing conditional connexin43-deficient mice with connexin30(-/-) mice...
  29. Boengler K, Ruiz Meana M, Gent S, Ungefug E, Soetkamp D, Miro Casas E, et al. Mitochondrial connexin 43 impacts on respiratory complex I activity and mitochondrial oxygen consumption. J Cell Mol Med. 2012;16:1649-55 pubmed publisher
    b>Connexin 43 (Cx43) is present at the sarcolemma and the inner membrane of cardiomyocyte subsarcolemmal mitochondria (SSM)...
  30. Dai P, Nakagami T, Tanaka H, Hitomi T, Takamatsu T. Cx43 mediates TGF-beta signaling through competitive Smads binding to microtubules. Mol Biol Cell. 2007;18:2264-73 pubmed
    ..regulated by microtubules (MTs), which anchor endogenous Smad2/3 to cytosol and also directly interact with connexin43 (Cx43), and the activity of TGF-beta is mediated by Cx43...
  31. Retamal M, Schalper K, Shoji K, Bennett M, Saez J. Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential. Proc Natl Acad Sci U S A. 2007;104:8322-7 pubmed
    ..Opening of Cx43 hemichannels is infrequent in normal extracellular Ca(2+) and enhanced by low Ca(2+), positive membrane potentials, ..
  32. Requardt R, Kaczmarczyk L, Dublin P, Wallraff Beck A, Mikeska T, Degen J, et al. Quality control of astrocyte-directed Cre transgenic mice: the benefits of a direct link between loss of gene expression and reporter activation. Glia. 2009;57:680-92 pubmed publisher
    ..Using a floxed Gja1 (Cx43) allele, we demonstrate the benefits of a direct link between reporter gene expression and target gene deletion to ..
  33. Tanaka M, Yamaguchi K, Tatsukawa T, Nishioka C, Nishiyama H, Theis M, et al. Lack of Connexin43-mediated bergmann glial gap junctional coupling does not affect cerebellar long-term depression, motor coordination, or eyeblink conditioning. Front Behav Neurosci. 2008;2:1 pubmed publisher
    ..b>Connexin43 (Cx43), a major component of astrocytic gap junction channels, is abundantly expressed in Bergmann glial cells...
  34. Plante I, Wallis A, Shao Q, Laird D. Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged. Biol Reprod. 2010;82:837-47 pubmed publisher
    ..We have previously shown that mammary glands from Gja1(Jrt/+) mice, harboring a mutation in the Gja1 gene encoding connexin (Cx) 43, have reduced Cx43 gap junction ..
  35. Boengler K, Stahlhofen S, van De Sand A, Gres P, Ruiz Meana M, Garcia Dorado D, et al. Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria. Basic Res Cardiol. 2009;104:141-7 pubmed publisher
    ..b>Connexin 43 (Cx43) is located at the inner membrane of SSM, and Cx43 is involved in the cardioprotection by ischemic ..
  36. Sanchez J, Rodriguez Sinovas A, Barba I, Miro Casas E, Fernandez Sanz C, Ruiz Meana M, et al. Activation of RISK and SAFE pathways is not involved in the effects of Cx43 deficiency on tolerance to ischemia-reperfusion injury and preconditioning protection. Basic Res Cardiol. 2013;108:351 pubmed publisher
    b>Connexin 43 (Cx43) deficiency increases myocardial tolerance to ischemia-reperfusion injury and abolishes preconditioning protection...
  37. Gustafson Wagner E, Sinn H, Chen Y, Wang D, Reiter R, Lin J, et al. Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects. Am J Physiol Heart Circ Physiol. 2007;293:H2680-92 pubmed
    ..Additionally, altered localization and decreased expression of connexin 43 are observed in the mXinalpha-null mouse heart, which, together with previously observed abnormal ..
  38. Froger N, Orellana J, Calvo C, Amigou E, Kozoriz M, Naus C, et al. Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective. Mol Cell Neurosci. 2010;45:37-46 pubmed publisher
    Astrocytes express high levels of connexin43, a protein that forms two types of channels: gap junction channels for direct intercellular communication, and hemichannels for exchanges with the extracellular space...
  39. Xu X, Francis R, Wei C, Linask K, Lo C. Connexin 43-mediated modulation of polarized cell movement and the directional migration of cardiac neural crest cells. Development. 2006;133:3629-39 pubmed
    b>Connexin 43 knockout (Cx43alpha1KO) mice have conotruncal heart defects that are associated with a reduction in the abundance of cardiac neural crest cells (CNCs) targeted to the heart...
  40. Huang C, Han X, Li X, Lam E, Peng W, Lou N, et al. Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury. J Neurosci. 2012;32:3333-8 pubmed publisher
    ..astrocytic ATP release, we here evaluated the impact on post-traumatic ATP release of deletion of connexins (Cx30/Cx43) in astrocytes...
  41. Grimston S, Goldberg D, Watkins M, Brodt M, Silva M, Civitelli R. Connexin43 deficiency reduces the sensitivity of cortical bone to the effects of muscle paralysis. J Bone Miner Res. 2011;26:2151-60 pubmed publisher
    We have shown previously that the effect of mechanical loading on bone depends in part on connexin43 (Cx43)...
  42. Bivi N, Condon K, Allen M, Farlow N, Passeri G, Brun L, et al. Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation. J Bone Miner Res. 2012;27:374-89 pubmed publisher
    b>Connexin 43 (Cx43) mediates osteocyte communication with other cells and with the extracellular milieu and regulates osteoblastic cell signaling and gene expression...
  43. Li K, Yao J, Shi L, Sawada N, Chi Y, Yan Q, et al. Reciprocal regulation between proinflammatory cytokine-induced inducible NO synthase (iNOS) and connexin43 in bladder smooth muscle cells. J Biol Chem. 2011;286:41552-62 pubmed publisher
    ..Stimulation of BSMCs with IL1? and TNF? increased connexin43 (Cx43) expression and function, which was associated with increased phosphorylation of vasodilator-stimulated ..
  44. Sridharan S, Brehm R, Bergmann M, Cooke P. Role of connexin 43 in Sertoli cells of testis. Ann N Y Acad Sci. 2007;1120:131-43 pubmed
    b>Connexin 43 (CX43, also known as GJA1) is the predominant testicular gap-junction protein. In the seminiferous epithelium, gap junctions occur between adjacent Sertoli cells and between Sertoli and germ cells...
  45. Lloyd S, Lewis G, Zhang Y, Paul E, Donahue H. Connexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading. J Bone Miner Res. 2012;27:2359-72 pubmed publisher
    b>Connexin 43 (Cx43) is the most abundant gap junction protein in bone and has been demonstrated as an integral component of skeletal homeostasis...
  46. Wiencken Barger A, Djukic B, Casper K, McCarthy K. A role for Connexin43 during neurodevelopment. Glia. 2007;55:675-86 pubmed
    b>Connexin43 (Cx43) is the predominant gap junction protein expressed in premitotic radial glial cells and mature astrocytes...
  47. Dobrowolski R, Sasse P, Schrickel J, Watkins M, Kim J, Rackauskas M, et al. The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans. Hum Mol Genet. 2008;17:539-54 pubmed
    ..characteristic anomalies of the fingers and toes, eyes, face and teeth, which are caused by mutations in the connexin 43 (Cx43) gene...
  48. Miro Casas E, Ruiz Meana M, Agullo E, Stahlhofen S, Rodriguez Sinovas A, Cabestrero A, et al. Connexin43 in cardiomyocyte mitochondria contributes to mitochondrial potassium uptake. Cardiovasc Res. 2009;83:747-56 pubmed publisher
    b>Connexin43 is present at the inner membrane of cardiomyocyte mitochondria (mCx43), but its function remains unknown...
  49. Grimston S, Brodt M, Silva M, Civitelli R. Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1). J Bone Miner Res. 2008;23:879-86 pubmed publisher
    In vitro data suggest that gap junctional intercellular communication mediated by connexin43 (Cx43) plays an important role in bone cell response to mechanical stimulation...
  50. Clauss S, Walker D, Kirby M, Schimel D, Lo C. Patterning of coronary arteries in wildtype and connexin43 knockout mice. Dev Dyn. 2006;235:2786-94 pubmed
    ..CA) insertion and branching patterns of the proximal coronary stems in the hearts of wildtype and heterozygous connexin43 knockout (Cx43alpha1 KO) mice...
  51. Negoro H, Kanematsu A, Doi M, Suadicani S, Matsuo M, Imamura M, et al. Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm. Nat Commun. 2012;3:809 pubmed publisher
    ..Here we demonstrate, using a novel method for automated recording of mouse micturition, that connexin43, a bladder gap junction protein, is a negative regulator of functional bladder capacity...
  52. Bejarano E, Girao H, Yuste A, Patel B, Marques C, Spray D, et al. Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner. Mol Biol Cell. 2012;23:2156-69 pubmed publisher
    ..autophagic degradation of GJ connexins, we analyzed the changes undergone by the fraction of plasma membrane connexin 43 targeted for macroautophagy and the sequence of events that trigger this process...
  53. Plotkin L, Lezcano V, Thostenson J, Weinstein R, Manolagas S, Bellido T. Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo. J Bone Miner Res. 2008;23:1712-21 pubmed publisher
    ..Herein, we evaluated its requirement for the in vivo actions of bisphosphonates using mice in which Cx43 was deleted specifically from osteocytes and osteoblasts (Cx43(DeltaOb-Ot/-) mice)...
  54. Grimston S, Watkins M, Brodt M, Silva M, Civitelli R. Enhanced periosteal and endocortical responses to axial tibial compression loading in conditional connexin43 deficient mice. PLoS ONE. 2012;7:e44222 pubmed publisher
    The gap junction protein, connexin43 (Cx43) is involved in mechanotransduction in bone...
  55. Boengler K, Ungefug E, Heusch G, Leybaert L, Schulz R. Connexin 43 impacts on mitochondrial potassium uptake. Front Pharmacol. 2013;4:73 pubmed publisher
    In cardiomyocytes, connexin 43 (Cx43) forms gap junctions and unopposed hemichannels at the plasma membrane, but the protein is also present at the inner membrane of subsarcolemmal mitochondria (SSM)...
  56. Lampe P, Cooper C, King T, Burt J. Analysis of Connexin43 phosphorylated at S325, S328 and S330 in normoxic and ischemic heart. J Cell Sci. 2006;119:3435-42 pubmed
    The functional consequences of Connexin43 (Cx43) phosphorylation remain largely unexplored...
  57. Francis R, Xu X, Park H, Wei C, Chang S, Chatterjee B, et al. Connexin43 modulates cell polarity and directional cell migration by regulating microtubule dynamics. PLoS ONE. 2011;6:e26379 pubmed publisher
    Knockout mice deficient in the gap junction gene connexin43 exhibit developmental anomalies associated with abnormal neural crest, primordial germ cell, and proepicardial cell migration...
  58. Bakker M, Boukens B, Mommersteeg M, Brons J, Wakker V, Moorman A, et al. Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system. Circ Res. 2008;102:1340-9 pubmed publisher
    ..Our data suggest a mechanism in which Tbx3 represses differentiation into ventricular working myocardium, thereby imposing the conduction system phenotype on cells within its expression domain. ..
  59. Mancuso M, Pasquali E, Leonardi S, Rebessi S, Tanori M, Giardullo P, et al. Role of connexin43 and ATP in long-range bystander radiation damage and oncogenesis in vivo. Oncogene. 2011;30:4601-8 pubmed publisher
    ..system using a mouse model in which intercellular communication is downregulated by targeted deletion of the connexin43 (Cx43) gene...
  60. Magnotti L, Goodenough D, Paul D. Deletion of oligodendrocyte Cx32 and astrocyte Cx43 causes white matter vacuolation, astrocyte loss and early mortality. Glia. 2011;59:1064-74 pubmed publisher
    ..Cx32-Cx43 dKO animals develop white matter vacuolation without obvious ultrastructural abnormalities in myelin...
  61. Kalcheva N, Qu J, Sandeep N, Garcia L, Zhang J, Wang Z, et al. Gap junction remodeling and cardiac arrhythmogenesis in a murine model of oculodentodigital dysplasia. Proc Natl Acad Sci U S A. 2007;104:20512-6 pubmed
    ..Oculodentodigital dysplasia (ODDD) is a multisystem syndrome due to mutations in the connexin43 (Cx43) gap junction channel gene...
  62. Brehm R, Zeiler M, Rüttinger C, Herde K, Kibschull M, Winterhager E, et al. A sertoli cell-specific knockout of connexin43 prevents initiation of spermatogenesis. Am J Pathol. 2007;171:19-31 pubmed
    The predominant testicular gap junctional protein connexin43 (cx43) is located between neighboring Sertoli cells (SCs) and between SCs and germ cells...
  63. Straub A, Billaud M, Johnstone S, Best A, Yemen S, Dwyer S, et al. Compartmentalized connexin 43 s-nitrosylation/denitrosylation regulates heterocellular communication in the vessel wall. Arterioscler Thromb Vasc Biol. 2011;31:399-407 pubmed publisher
    ..To determine whether S-nitrosylation of connexins (Cxs) modulates gap junction communication between endothelium and smooth muscle...
  64. Anand R, Dai S, Gribar S, Richardson W, Kohler J, Hoffman R, et al. A role for connexin43 in macrophage phagocytosis and host survival after bacterial peritoneal infection. J Immunol. 2008;181:8534-8543 pubmed
    ..We now demonstrate a previously unrecognized role for the gap junction protein connexin43 (Cx43) in the regulation of phagocytosis by macrophages and in the host response to bacterial infection of the ..
  65. Lima F, Niger C, Hebert C, Stains J. Connexin43 potentiates osteoblast responsiveness to fibroblast growth factor 2 via a protein kinase C-delta/Runx2-dependent mechanism. Mol Biol Cell. 2009;20:2697-708 pubmed publisher
    In this study, we examine the role of the gap junction protein, connexin43 (Cx43), in the transcriptional response of osteocalcin to fibroblast growth factor 2 (FGF2) in MC3T3 osteoblasts...
  66. Danik S, Rosner G, Lader J, Gutstein D, Fishman G, Morley G. Electrical remodeling contributes to complex tachyarrhythmias in connexin43-deficient mouse hearts. FASEB J. 2008;22:1204-12 pubmed
    Loss of connexin43 (Cx43) gap junction channels in the heart results in a marked increase in the incidence of spontaneous and inducible polymorphic ventricular tachyarrhythmias (PVTs)...
  67. Kozoriz M, Bechberger J, Bechberger G, Suen M, Moreno A, Maass K, et al. The connexin43 C-terminal region mediates neuroprotection during stroke. J Neuropathol Exp Neurol. 2010;69:196-206 pubmed publisher
    b>Connexin43 plays an important role in neuroprotection in experimental stroke models; reducing the expression of this gap junction protein in astrocytes enhances injury upon middle cerebral artery occlusion (MCAO)...
  68. Maass K, Shibayama J, Chase S, Willecke K, Delmar M. C-terminal truncation of connexin43 changes number, size, and localization of cardiac gap junction plaques. Circ Res. 2007;101:1283-91 pubmed
    Haplodeficient mice expressing carboxyl-terminally truncated Cx43 (K258stop/KO), instead of the wild-type Cx43 isoform, reach adulthood and reveal no abnormalities in heart morphology...
  69. Chaible L, Sanches D, Cogliati B, Mennecier G, Dagli M. Delayed osteoblastic differentiation and bone development in Cx43 knockout mice. Toxicol Pathol. 2011;39:1046-55 pubmed publisher
    GJA1 gene (Connexin43, also known as Cx43) is the most abundant gap junction protein isoform in animal cells and is associated with bone development in embryos...
  70. Weider K, Bergmann M, Giese S, Guillou F, Failing K, Brehm R. Altered differentiation and clustering of Sertoli cells in transgenic mice showing a Sertoli cell specific knockout of the connexin 43 gene. Differentiation. 2011;82:38-49 pubmed publisher
    ..analysis revealed that Sertoli cell specific knockout of the predominant testicular gap junction protein connexin 43 results in a spermatogenic arrest at the level of spermatogonia or Sertoli cell-only syndrome, intratubular ..
  71. Jansen J, van Veen T, de Jong S, van der Nagel R, van Stuijvenberg L, Driessen H, et al. Reduced Cx43 expression triggers increased fibrosis due to enhanced fibroblast activity. Circ Arrhythm Electrophysiol. 2012;5:380-90 pubmed publisher
    ..We hypothesized that reduced connexin43 (Cx43) expression is responsible for enhanced fibrosis in the remodeled heart, resulting in an arrhythmogenic ..
  72. Fukumasu H, Avanzo J, Sanches D, Mennecier G, Mori C, Dagli M. Higher susceptibility of spontaneous and NNK-induced lung neoplasms in connexin 43 deficient CD1?×?AJ F1 mice: paradoxical expression of connexin 43 during lung carcinogenesis. Mol Carcinog. 2013;52:497-506 pubmed publisher
    ..Here, we evaluated the importance of Connexin43 (Cx43) in spontaneous and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung carcinogenesis...
  73. Machtaler S, Dang Lawson M, Choi K, Jang C, Naus C, Matsuuchi L. The gap junction protein Cx43 regulates B-lymphocyte spreading and adhesion. J Cell Sci. 2011;124:2611-21 pubmed publisher
    The gap junction protein connexin43 (Cx43) is widely expressed in mammalian cells and forms intercellular channels for the transfer of small molecules between adjacent cells, as well as hemichannels that mediate bidirectional transport of ..
  74. Zhang Y, Paul E, Sathyendra V, Davison A, Sharkey N, Bronson S, et al. Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone. PLoS ONE. 2011;6:e23516 pubmed publisher
    ..Deletion of connexin 43, the predominant gap junction protein in bone, is embryonic lethal making it challenging to examine the role of ..
  75. Siller Jackson A, Burra S, Gu S, Xia X, Bonewald L, Sprague E, et al. Adaptation of connexin 43-hemichannel prostaglandin release to mechanical loading. J Biol Chem. 2008;283:26374-82 pubmed publisher
    ..of PGE(2) by shear stress were significantly inhibited by a potent antibody we developed that specifically blocks Cx43-hemichannels, but not gap junctions or other channels...