Gip

Summary

Gene Symbol: Gip
Description: gastric inhibitory polypeptide
Alias: gastric inhibitory polypeptide, glucose-dependent insulinotropic polypeptide
Species: mouse
Products:     Gip

Top Publications

  1. Kim S, Nian C, McIntosh C. Activation of lipoprotein lipase by glucose-dependent insulinotropic polypeptide in adipocytes. A role for a protein kinase B, LKB1, and AMP-activated protein kinase cascade. J Biol Chem. 2007;282:8557-67 pubmed
    Glucose-dependent insulinotropic polypeptide (GIP) has been mainly studied because of its glucose-dependent insulinotropic action and its ability to regulate beta-cell proliferation and survival...
  2. Fujita Y, Wideman R, Asadi A, Yang G, Baker R, Webber T, et al. Glucose-dependent insulinotropic polypeptide is expressed in pancreatic islet alpha-cells and promotes insulin secretion. Gastroenterology. 2010;138:1966-75 pubmed publisher
    Glucose-dependent insulinotropic polypeptide (GIP) and the proglucagon product glucagon-like peptide-1 (GLP-1) are gastrointestinal hormones that are released in response to nutrient intake and promote insulin secretion...
  3. Mellitzer G, Beucher A, Lobstein V, Michel P, Robine S, Kedinger M, et al. Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival. J Clin Invest. 2010;120:1708-21 pubmed publisher
    ..Our data help unravel the role of enteroendocrine cells and hormones in lipid absorption and maintenance of the intestinal epithelium. ..
  4. Miyawaki K, Yamada Y, Ban N, Ihara Y, Tsukiyama K, Zhou H, et al. Inhibition of gastric inhibitory polypeptide signaling prevents obesity. Nat Med. 2002;8:738-42 pubmed
    Secretion of gastric inhibitory polypeptide (GIP), a duodenal hormone, is primarily induced by absorption of ingested fat. Here we describe a novel pathway of obesity promotion via GIP...
  5. Prasadan K, Koizumi M, Tulachan S, Shiota C, Lath N, Paredes J, et al. The expression and function of glucose-dependent insulinotropic polypeptide in the embryonic mouse pancreas. Diabetes. 2011;60:548-54 pubmed publisher
    Glucose-dependent insulinotropic polypeptide (GIP) is a member of a structurally related group of hormones that also includes glucagon, glucagon-like peptides, and secretin...
  6. Kim S, Winter K, Nian C, Tsuneoka M, Koda Y, McIntosh C. Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down. J Biol Chem. 2005;280:22297-307 pubmed
    The hormone glucose-dependent insulinotropic polypeptide (GIP) potently stimulates insulin secretion and promotes beta-cell proliferation and cell survival...
  7. Fukami A, Seino Y, Ozaki N, Yamamoto M, Sugiyama C, Sakamoto Miura E, et al. Ectopic expression of GIP in pancreatic β-cells maintains enhanced insulin secretion in mice with complete absence of proglucagon-derived peptides. Diabetes. 2013;62:510-8 pubmed publisher
    ..Responses of glucose-dependent insulinotropic polypeptide (GIP) to both oral and intraperitoneal glucose loads were unexpectedly enhanced in Gcg(gfp/gfp) mice, and ..
  8. Hansotia T, Drucker D. GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice. Regul Pept. 2005;128:125-34 pubmed
    Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are gut-derived incretins secreted in response to nutrient ingestion...
  9. Althage M, Ford E, Wang S, Tso P, Polonsky K, Wice B. Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet. J Biol Chem. 2008;283:18365-76 pubmed publisher
    ..cell located in the proximal small intestine that produces glucose-dependent insulinotropic polypeptide (GIP), xenin, and potentially other unknown hormones...

More Information

Publications69

  1. Kile B, Hentges K, Clark A, Nakamura H, Salinger A, Liu B, et al. Functional genetic analysis of mouse chromosome 11. Nature. 2003;425:81-6 pubmed
    ..The mutations reveal new defects in haematopoiesis, craniofacial and cardiovascular development, and fertility. ..
  2. Varol C, Zvibel I, Spektor L, Mantelmacher F, Vugman M, Thurm T, et al. Long-acting glucose-dependent insulinotropic polypeptide ameliorates obesity-induced adipose tissue inflammation. J Immunol. 2014;193:4002-9 pubmed publisher
    ..The glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone that mediates postprandial insulin secretion and has anabolic effects on the adipose tissue...
  3. Ugleholdt R, Poulsen M, Holst P, Irminger J, Orskov C, Pedersen J, et al. Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor. J Biol Chem. 2006;281:11050-7 pubmed
    ..of the incretin hormones, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), and their role in type 2 diabetes currently attract great interest...
  4. Boles M, Wilkinson B, Wilming L, Liu B, Probst F, Harrow J, et al. Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin. PLoS Genet. 2009;5:e1000759 pubmed publisher
    ..Our data show that the classical positional mapping approach of disease mutation identification can be extended to large target regions using high-throughput sequencing. ..
  5. Grigoryan M, Kedees M, Guz Y, Teitelman G. Phenotype of entero-endocrine L cells becomes restricted during development. Dev Dyn. 2012;241:1986-92 pubmed publisher
    Glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP) are hormones secreted by L and K cells, respectively, and by LK cells...
  6. Suzuki K, Harada N, Yamane S, Nakamura Y, Sasaki K, Nasteska D, et al. Transcriptional regulatory factor X6 (Rfx6) increases gastric inhibitory polypeptide (GIP) expression in enteroendocrine K-cells and is involved in GIP hypersecretion in high fat diet-induced obesity. J Biol Chem. 2013;288:1929-38 pubmed publisher
    b>Gastric inhibitory polypeptide (GIP) is an incretin released from enteroendocrine K-cells in response to nutrient ingestion...
  7. Lyssenko V, Eliasson L, Kotova O, Pilgaard K, Wierup N, Salehi A, et al. Pleiotropic effects of GIP on islet function involve osteopontin. Diabetes. 2011;60:2424-33 pubmed publisher
    The incretin hormone GIP (glucose-dependent insulinotropic polypeptide) promotes pancreatic ?-cell function by potentiating insulin secretion and ?-cell proliferation...
  8. Brial F, Lussier C, Belleville K, Sarret P, Boudreau F. Ghrelin Inhibition Restores Glucose Homeostasis in Hepatocyte Nuclear Factor-1α (MODY3)-Deficient Mice. Diabetes. 2015;64:3314-20 pubmed publisher
    ..An increase in ghrelin gene transcript and a decrease in glucose-dependent insulinotropic polypeptide (GIP) gene transcripts were observed in the gut of Hnf1α-null mice...
  9. Mohlke K, Nichols W, Westrick R, Novak E, Cooney K, Swank R, et al. A novel modifier gene for plasma von Willebrand factor level maps to distal mouse chromosome 11. Proc Natl Acad Sci U S A. 1996;93:15352-7 pubmed
    ..of as many as 2407 meioses established a high resolution genetic map with gene order Cola1-Itg3a-Ngfr-Mvwf/Gip-Hoxb9-Hoxb1++ +-Cbx'rs2-Cox5a-Gfap. The Mvwf candidate interval between Ngfr and Hoxb9 is approximately 0...
  10. COON S, Schwartz J, Rajendran V, Jepeal L, Singh S. Glucose-dependent insulinotropic polypeptide regulates dipeptide absorption in mouse jejunum. Am J Physiol Gastrointest Liver Physiol. 2013;305:G678-84 pubmed publisher
    Glucose-dependent insulinotropic polypeptide (GIP) secreted from jejunal mucosal K cells augments insulin secretion and plays a critical role in the pathogenesis of obesity and Type 2 diabetes mellitus...
  11. Cho H, Kosari S, Hunne B, Callaghan B, Rivera L, Bravo D, et al. Differences in hormone localisation patterns of K and L type enteroendocrine cells in the mouse and pig small intestine and colon. Cell Tissue Res. 2015;359:693-698 pubmed publisher
    ..the patterns of colocalisation of the conventional K cell marker, glucagon-like insulinotropic peptide (GIP), and the L cell markers, glucagon like peptide-1 (GLP-1) and peptide YY (PYY), in enteroendocrine cells (EEC) of ..
  12. Edfalk S, Steneberg P, Edlund H. Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion. Diabetes. 2008;57:2280-7 pubmed publisher
    ..Plasma insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucose levels in response to acute oral fat diet were determined in Gpr40 ..
  13. Psichas A, Glass L, Sharp S, Reimann F, Gribble F. Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells. Br J Pharmacol. 2016;173:888-98 pubmed publisher
    ..Kir 3, (GIRK) channels in glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) secretion. Purified murine L and K cells were analysed for expression of galanin receptors and GIRK subunits...
  14. Boylan M, Jepeal L, Jarboe L, Wolfe M. Cell-specific expression of the glucose-dependent insulinotropic polypeptide gene in a mouse neuroendocrine tumor cell line. J Biol Chem. 1997;272:17438-43 pubmed
    Glucose-dependent insulinotropic polypeptide (GIP) is a 42-amino acid gastrointestinal regulatory peptide that, in the presence of glucose, stimulates insulin secretion...
  15. Mooney M, Abdel Wahab Y, Morgan L, O Harte F, Flatt P. Detection of glycated gastric inhibitory polypeptide within the intestines of diabetic obese (ob/ob) mice. Endocrine. 2001;16:167-71 pubmed
    b>Gastric inhibitory polypeptide (GIP) is produced within endocrine cells of the small intestine and released into the circulation upon nutrient ingestion...
  16. Wang S, Chi M, Li L, Moley K, Wice B. Studies with GIP/Ins cells indicate secretion by gut K cells is KATP channel independent. Am J Physiol Endocrinol Metab. 2003;284:E988-1000 pubmed
    K cells are a subpopulation of enteroendocrine cells that secrete glucose-dependent insulinotropic polypeptide (GIP), a hormone that promotes glucose homeostasis and obesity...
  17. Mulvihill E, Varin E, Gladanac B, Campbell J, Ussher J, Baggio L, et al. Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis. Cell Metab. 2017;25:152-165 pubmed publisher
    ..Surprisingly, DPP4+ cells of bone marrow origin mediated the selective degradation of fasting GIP, but not GLP-1...
  18. Iwasaki K, Harada N, Sasaki K, Yamane S, Iida K, Suzuki K, et al. Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion. Endocrinology. 2015;156:837-46 pubmed publisher
    b>Gastric inhibitory polypeptide (GIP) is an incretin secreted from enteroendocrine K cells in response to meal ingestion...
  19. Martin C, Irwin N, Flatt P, Gault V. A novel acylated form of (d-Ala(2))GIP with improved antidiabetic potential, lacking effect on body fat stores. Biochim Biophys Acta. 2013;1830:3407-13 pubmed publisher
    Rapid enzymatic degradation of the incretin hormone, glucose-dependent insulinotropic polypeptide (GIP), limits therapeutic use of the native peptide for diabetes...
  20. Naitoh R, Miyawaki K, Harada N, Mizunoya W, Toyoda K, Fushiki T, et al. Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice. Biochem Biophys Res Commun. 2008;376:21-5 pubmed publisher
    b>Gastric inhibitory polypeptide (GIP) is an incretin and directly promotes fat accumulation in adipocytes...
  21. Mieczkowska A, Bouvard B, Chappard D, Mabilleau G. Glucose-dependent insulinotropic polypeptide (GIP) directly affects collagen fibril diameter and collagen cross-linking in osteoblast cultures. Bone. 2015;74:29-36 pubmed publisher
    Glucose-dependent insulinotropic polypeptide (GIP) is absolutely crucial in order to obtain optimal bone strength and collagen quality...
  22. Kim S, Nian C, McIntosh C. Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytes. J Biol Chem. 2007;282:34139-47 pubmed
    Studies on the physiological roles of the incretin hormone, glucose-dependent insulinotropic polypeptide (GIP) have largely focused on its insulinotropic action and ability to regulate beta-cell mass...
  23. Yeung C, Wong C, Chung S, Chung S, Chow B. Glucose-dependent insulinotropic polypeptide gene expression in the stomach: revealed by a transgenic mouse study, in situ hybridization and immunohistochemical staining. Mol Cell Endocrinol. 1999;154:161-70 pubmed
    Glucose-dependent insulinotropic polypeptide (GIP) plays an important role in stimulating insulin release in the pancreas as well as inhibiting gastric acid secretion in the stomach...
  24. Flock G, Cao X, Maziarz M, Drucker D. Activation of enteroendocrine membrane progesterone receptors promotes incretin secretion and improves glucose tolerance in mice. Diabetes. 2013;62:283-90 pubmed publisher
    ..Enteral progesterone administration increased plasma levels of GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and insulin, and improved oral glucose tolerance in an RU486-insensitve manner in mice: however, systemic ..
  25. Gault V, Kerr B, Harriott P, Flatt P. Administration of an acylated GLP-1 and GIP preparation provides added beneficial glucose-lowering and insulinotropic actions over single incretins in mice with Type 2 diabetes and obesity. Clin Sci (Lond). 2011;121:107-17 pubmed publisher
    ..study examined the glucose-lowering and insulinotropic properties of acylated GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) peptides in Type 2 diabetes and obesity...
  26. Bonnavion R, Teinturier R, Jaafar R, Ripoche D, Leteurtre E, Chen Y, et al. Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors. Mol Cell Biol. 2015;35:3274-83 pubmed publisher
    ..Our work provides insight into the histogenesis of pancreatic gastrin-expressing tumors. ..
  27. Zhou J, Hao Z, Irwin N, Berthoud H, Ye J. Gastric inhibitory polypeptide (GIP) is selectively decreased in the roux-limb of dietary obese mice after RYGB surgery. PLoS ONE. 2015;10:e0134728 pubmed publisher
    b>Gastric inhibitory polypeptide (GIP, glucose-dependent insulinotropic polypeptide) is expressed by intestinal K cells to regulate glucose-induced insulin secretion...
  28. Ding K, Zhong Q, Xie D, Chen H, Della Fera M, Bollag R, et al. Effects of glucose-dependent insulinotropic peptide on behavior. Peptides. 2006;27:2750-5 pubmed
    Glucose-dependent insulinotropic peptide (GIP) is an incretin hormone that rises rapidly in response to nutrient ingestion...
  29. Schieldrop P, Gelling R, Elliot R, Hewitt J, Kieffer T, McIntosh C, et al. Isolation of a murine glucose-dependent insulinotropic polypeptide (GIP) cDNA from a tumor cell line (STC6-14) and quantification of glucose-induced increases in GIP mRNA. Biochim Biophys Acta. 1996;1308:111-3 pubmed
    A 537 base pair cDNA clone for murine GIP has been isolated. The elucidated sequence encodes an open reading frame of 432 base pairs which codes for a 144 amino acid precursor...
  30. Omar B, Banke E, Guirguis E, Ã…kesson L, Manganiello V, Lyssenko V, et al. Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes--a role for the transcription factor NFAT and phosphodiesterase 3B. Biochem Biophys Res Commun. 2012;425:812-7 pubmed publisher
    The incretin - glucose-dependent insulinotropic polypeptide (GIP) - and the pro-inflammatory cytokine osteopontin are known to have important roles in the regulation of adipose tissue functions...
  31. Ramesh N, Mortazavi S, Unniappan S. Nesfatin-1 stimulates glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide secretion from STC-1 cells in vitro. Biochem Biophys Res Commun. 2015;462:124-30 pubmed publisher
    ..Meal responsive insulin secretion is regulated by incretins glucagon-like peptide-1 (GLP-1) and glucose dependent insulinotropic polypeptide (GIP)...
  32. Egerod K, Engelstoft M, Grunddal K, Nøhr M, Secher A, Sakata I, et al. A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin. Endocrinology. 2012;153:5782-95 pubmed publisher
    ..cells demonstrated expression of not only CCK but also glucagon-like peptide 1 (GLP-1), gastric inhibitory peptide (GIP), peptide YY (PYY), neurotensin, and secretin, but not somatostatin...
  33. Kahles F, Meyer C, Diebold S, Foldenauer A, Stohr R, Möllmann J, et al. Glucose-dependent insulinotropic peptide secretion is induced by inflammatory stimuli in an interleukin-1-dependent manner in mice. Diabetes Obes Metab. 2016;18:1147-1151 pubmed publisher
    ..the present study, we assess the relevance of the other incretin hormone, glucose-dependent insulinotropic peptide (GIP), as a regulator of glucose metabolism under inflammatory conditions...
  34. Nyberg J, Jacobsson C, Anderson M, Eriksson P. Immunohistochemical distribution of glucose-dependent insulinotropic polypeptide in the adult rat brain. J Neurosci Res. 2007;85:2099-119 pubmed
    We have previously demonstrated that glucose-dependent insulinotropic polypeptide (GIP; gastric inhibitory polypeptide) is present in the adult rat hippocampus...
  35. Moffett R, Vasu S, Thorens B, Drucker D, Flatt P. Incretin receptor null mice reveal key role of GLP-1 but not GIP in pancreatic beta cell adaptation to pregnancy. PLoS ONE. 2014;9:e96863 pubmed publisher
    ..were explored in C57BL6/J mice lacking functional receptors for glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP)...
  36. García Martínez J, Chocarro Calvo A, De La Vieja A, García Jiménez C. Insulin drives glucose-dependent insulinotropic peptide expression via glucose-dependent regulation of FoxO1 and LEF1/?-catenin. Biochim Biophys Acta. 2014;1839:1141-50 pubmed publisher
    ..show that insulin stimulates the expression of the major human incretin, glucose-dependent insulinotropic peptide (GIP) in enteroendocrine cells but requires glucose to do it...
  37. Mantelmacher F, Fishman S, Cohen K, Pasmanik Chor M, Yamada Y, Zvibel I, et al. Glucose-Dependent Insulinotropic Polypeptide Receptor Deficiency Leads to Impaired Bone Marrow Hematopoiesis. J Immunol. 2017;198:3089-3098 pubmed publisher
    ..The glucose-dependent insulinotropic polypeptide (GIP) is a gut-derived incretin hormone that mediates postprandial insulin secretion and has anabolic effects on adipose ..
  38. Cani P, Holst J, Drucker D, Delzenne N, Thorens B, Burcelin R, et al. GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion. Mol Cell Endocrinol. 2007;276:18-23 pubmed
    Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins secreted in response to oral glucose ingestion by intestinal L and K cells, respectively...
  39. Chen S, Okahara F, Osaki N, Shimotoyodome A. Increased GIP signaling induces adipose inflammation via a HIF-1α-dependent pathway and impairs insulin sensitivity in mice. Am J Physiol Endocrinol Metab. 2015;308:E414-25 pubmed publisher
    Glucose-dependent insulinotropic polypeptide (GIP) is a gut hormone secreted in response to dietary fat and glucose. The blood GIP level is elevated in obesity and diabetes...
  40. Hiromura M, Mori Y, Kohashi K, Terasaki M, Shinmura K, Negoro T, et al. Suppressive Effects of Glucose-Dependent Insulinotropic Polypeptide on Cardiac Hypertrophy and Fibrosis in Angiotensin II-Infused Mouse Models. Circ J. 2016;80:1988-97 pubmed publisher
    ..However, effects of GIP on the heart have remained unclear. To address this question, in vitro and in vivo experiments were conducted...
  41. Fujita K, Tokuda H, Yamamoto N, Kainuma S, Kawabata T, Sakai G, et al. Incretins amplify TNF-?-stimulated IL-6 synthesis in osteoblasts: Suppression of the I?B/NF-?B pathway. Int J Mol Med. 2017;39:1053-1060 pubmed publisher
    Incretins including glucagon-like peptide-1 (GLP-1) and glucose?dependent insulinotropic polypeptide (GIP) secreted from the small intestine after oral food ingestion are currently recognized to stimulate insulin secretion from ..
  42. Jepeal L, Boylan M, Michael Wolfe M. GATA-4 upregulates glucose-dependent insulinotropic polypeptide expression in cells of pancreatic and intestinal lineage. Mol Cell Endocrinol. 2008;287:20-9 pubmed publisher
    A thorough examination of glucose-dependent insulinotropic polypeptide (GIP) expression has been hampered by difficulty in isolating widely dispersed, GIP-producing enteroendocrine K-cells...
  43. Zhou H, Yamada Y, Tsukiyama K, Miyawaki K, Hosokawa M, Nagashima K, et al. Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action. Biochem Biophys Res Commun. 2005;335:937-42 pubmed
    Gut hormone gastric inhibitory polypeptide (GIP) stimulates insulin secretion from pancreatic beta-cells upon ingestion of nutrients...
  44. Kolic J, Spigelman A, Smith A, Manning Fox J, MacDonald P. Insulin secretion induced by glucose-dependent insulinotropic polypeptide requires phosphatidylinositol 3-kinase γ in rodent and human β-cells. J Biol Chem. 2014;289:32109-20 pubmed publisher
    ..activity in β-cells and can be activated by the glucose-dependent insulinotropic polypeptide (GIP)...
  45. Yamada C, Yamada Y, Tsukiyama K, Yamada K, Yamane S, Harada N, et al. Genetic inactivation of GIP signaling reverses aging-associated insulin resistance through body composition changes. Biochem Biophys Res Commun. 2007;364:175-80 pubmed
    ..b>Gastric inhibitory polypeptide (GIP) is known to promote efficient storage of ingested nutrients into adipose tissue; we examined ..
  46. Irwin N, Hunter K, Flatt P. Comparison of independent and combined chronic metabolic effects of GIP and CB1 receptor blockade in high-fat fed mice. Peptides. 2008;29:1036-41 pubmed publisher
    b>GIP receptor antagonism with (Pro3)GIP protects against obesity, insulin resistance, glucose intolerance and associated disturbances in mice fed high-fat diet...
  47. Abdullah N, Beg M, Soares D, Dittman J, McGraw T. Downregulation of a GPCR by β-Arrestin2-Mediated Switch from an Endosomal to a TGN Recycling Pathway. Cell Rep. 2016;17:2966-2978 pubmed publisher
    Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in nutrient homeostasis...
  48. Vanhorenbeeck V, Jenny M, Cornut J, Gradwohl G, Lemaigre F, Rousseau G, et al. Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation. Dev Biol. 2007;305:685-94 pubmed
    ..In conclusion, our data reveal partially redundant roles for HNF-6 and OC-2 in developing pancreas and identify new markers for antero-posterior patterning of the gut and for enteroendocrine differentiation. ..
  49. Fujitani Y, Fujitani S, Boyer D, Gannon M, Kawaguchi Y, Ray M, et al. Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev. 2006;20:253-66 pubmed
  50. Sommer C, Mostoslavsky G. RNA-Seq analysis of enteroendocrine cells reveals a role for FABP5 in the control of GIP secretion. Mol Endocrinol. 2014;28:1855-65 pubmed publisher
    In response to fat intake, enteroendocrine K cells release the hormone glucose-dependent insulinotropic polypeptide (GIP)...
  51. Jepeal L, Fujitani Y, Boylan M, Wilson C, Wright C, Wolfe M. Cell-specific expression of glucose-dependent-insulinotropic polypeptide is regulated by the transcription factor PDX-1. Endocrinology. 2005;146:383-91 pubmed
    Glucose-dependent insulinotropic polypeptide (GIP) is a potent stimulator of insulin secretion and comprises an important component of the enteroinsular axis...
  52. Tsukiyama K, Yamada Y, Yamada C, Harada N, Kawasaki Y, Ogura M, et al. Gastric inhibitory polypeptide as an endogenous factor promoting new bone formation after food ingestion. Mol Endocrinol. 2006;20:1644-51 pubmed
    ..Meal ingestion elicits secretion of the gut hormone gastric inhibitory polypeptide (GIP) from endocrine K cells in the duodenum...
  53. Berglund L, Lyssenko V, Ladenvall C, Kotova O, Edsfeldt A, Pilgaard K, et al. Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB. Diabetes. 2016;65:239-54 pubmed publisher
    Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone with extrapancreatic effects beyond glycemic control. Here we demonstrate unexpected effects of GIP signaling in the vasculature...
  54. Boylan M, Glazebrook P, Tatalovic M, Wolfe M. Gastric inhibitory polypeptide immunoneutralization attenuates development of obesity in mice. Am J Physiol Endocrinol Metab. 2015;309:E1008-18 pubmed publisher
    Previous reports have suggested that the abrogation of gastric inhibitory polypeptide (GIP) signaling could be exploited to prevent and treat obesity and obesity-related disorders in humans...
  55. Boyer D, Fujitani Y, Gannon M, Powers A, Stein R, Wright C. Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression. Dev Biol. 2006;298:616-31 pubmed
    ..These results reveal a role for distal cis-regulatory elements in achieving the correct level of extra-pancreatic Pdx1 expression, which is necessary for the production of duodenal GIP cells and stomach gastrin cells.
  56. Singh S, Bartoo A, Krishnan S, Boylan M, Schwartz J, Michael Wolfe M. Glucose-dependent insulinotropic polypeptide (GIP) stimulates transepithelial glucose transport. Obesity (Silver Spring). 2008;16:2412-6 pubmed publisher
    The purpose of this study was to characterize the effects of glucose-dependent insulinotropic peptide (GIP) on small intestinal glucose transport in vitro. Stripped proximal jejunum from fasted mice was mounted in Ussing chambers...
  57. Tsukiyama K, Yamada Y, Miyawaki K, Hamasaki A, Nagashima K, Hosokawa M, et al. Gastric inhibitory polypeptide is the major insulinotropic factor in K(ATP) null mice. Eur J Endocrinol. 2004;151:407-12 pubmed
    ..b>Gastric inhibitory polypeptide (GIP) is a physiological incretin that stimulates insulin release upon ingestion of nutrients...
  58. Piccand J, Meunier A, Merle C, Jia Z, Barnier J, Gradwohl G. Pak3 promotes cell cycle exit and differentiation of ?-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice. Diabetes. 2014;63:203-15 pubmed publisher
    ..In the adult, Pak3 is required for the proper control of glucose homeostasis under challenging HFD. ..
  59. Nasteska D, Harada N, Suzuki K, Yamane S, Hamasaki A, Joo E, et al. Chronic reduction of GIP secretion alleviates obesity and insulin resistance under high-fat diet conditions. Diabetes. 2014;63:2332-43 pubmed publisher
    b>Gastric inhibitory polypeptide (GIP) exhibits potent insulinotropic effects on β-cells and anabolic effects on bone formation and fat accumulation...
  60. Ramshur E, Rull T, Wice B. Novel insulin/GIP co-producing cell lines provide unexpected insights into Gut K-cell function in vivo. J Cell Physiol. 2002;192:339-50 pubmed
    ..sub-population of EE cells called Gut K-cells produces and secretes glucose-dependent insulinotropic peptide (GIP), a hormone important for glucose homeostasis...