Gene Symbol: Gigyf1
Description: GRB10 interacting GYF protein 1
Alias: Perq1, mKIAA4110, GRB10-interacting GYF protein 1, PERQ amino acid-rich with GYF domain-containing protein 1, GRB10 interacting GYF protein 2, PERQ amino acid rich, with GYF domain 1
Species: mouse
Products:     Gigyf1

Top Publications

  1. Wilson M, Riemer C, Martindale D, Schnupf P, Boright A, Cheung T, et al. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. Nucleic Acids Res. 2001;29:1352-65 pubmed
    ..frame flanked by ACHE: and Asr2, a novel cation-chloride cotransporter interacting protein Cip1, Ephb4, Zan and Perq1. While some of these genes have been previously described, in each case we present new data derived from our ..
  2. Giovannone B, Lee E, Laviola L, Giorgino F, Cleveland K, Smith R. Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. J Biol Chem. 2003;278:31564-73 pubmed
    ..screening, the N terminus of Grb10 was shown to interact with two novel proteins, designated GIGYF1 (Grb10 interacting GYF protein 1) and GIGYF2...
  3. Giovannone B, Tsiaras W, de la Monte S, Klysik J, Lautier C, Karashchuk G, et al. GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling. Hum Mol Genet. 2009;18:4629-39 pubmed publisher
    ..These data provide further evidence for an important role of GIGYF2 in age-related neurodegeneration and IGF pathway signaling. ..