Ghrhr

Summary

Gene Symbol: Ghrhr
Description: growth hormone releasing hormone receptor
Alias: Ghrfr, lit, little, growth hormone-releasing hormone receptor, GHRH receptor, GRF receptor, GRFR, growth hormone-releasing factor receptor
Species: mouse

Top Publications

  1. ncbi Sexual dimorphism and growth hormone induction of murine pheromone-binding proteins
    D Johnson
    Centre for Genome Research, University of Edinburgh, UK
    J Mol Endocrinol 14:21-34. 1995
  2. ncbi Molecular basis of the little mouse phenotype and implications for cell type-specific growth
    S C Lin
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla 92093 0648
    Nature 364:208-13. 1993
  3. ncbi Fine structure of somatotrophs and mammotrophs in the pituitary pars distalis of the little (lit) mutant mouse
    E Christensen
    Virchows Arch B Cell Pathol Incl Mol Pathol 37:89-96. 1981
  4. ncbi Mammary gland branching morphogenesis is diminished in mice with a deficiency of insulin-like growth factor-I (IGF-I), but not in mice with a liver-specific deletion of IGF-I
    R Gregg Richards
    Hormones and Cancer Group, Laboratory of Molecular Carcinogenesis, National Institute of Environmental and Health Science, P O Box 12233, MD D4 04, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 145:3106-10. 2004
  5. ncbi Primary B cell development is impaired in mice with defects of the pituitary/thyroid axis
    E Montecino-Rodriguez
    Department of Pathology and Laboratory Medicine and the Jonsson Comprehensive Cancer Center, School of Medicine, University of California, Los Angeles 90095, USA
    J Immunol 159:2712-9. 1997
  6. ncbi Regulation of metabolic water and protein compartments by insulin-like growth factor-I and testosterone in growth hormone-deficient lit/lit mice
    L R Donahue
    Jackson Laboratory, Bar Harbor, Maine 04609
    J Endocrinol 139:431-9. 1993
  7. pmc Alterations in xenobiotic metabolism in the long-lived Little mice
    Daniel Amador-Noguez
    Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX 77030, USA
    Aging Cell 6:453-70. 2007
  8. ncbi A chemical mutagenesis screen to identify modifier genes that interact with growth hormone and TGF-beta signaling pathways
    Subburaman Mohan
    Musculoskeletal Disease Center, Loma Linda VA Health Care Systems, Loma Linda, CA 92357, USA
    Bone 42:388-95. 2008
  9. ncbi New insights into the regulation of somatotrope function using genetic and transgenic models
    L A Frohman
    Department of Medicine, University of Illinois at Chicago 60612, USA
    Metabolism 45:1-3. 1996
  10. ncbi Gene expression of hypothalamic growth hormone (GH)-releasing hormone and somatostatin does not correlate with pulsatile secretion of GH in the adult mouse
    S Murao
    First Department of Internal Medicine, Kagawa Medical School, Japan
    Res Commun Mol Pathol Pharmacol 89:269-77. 1995

Research Grants

Scientific Experts

  • B D Gaylinn
  • Dennis J Chia
  • Holly M Brown-Borg
  • Daniel Amador-Noguez
  • William R Swindell
  • Gabor Halmos
  • Beverly J Paigen
  • Debananda Pati
  • Hippokratis Kiaris
  • L Bunger
  • Rodolfo C Puche
  • LINDA TOTH
  • Hideto Ikushima
  • K Iida
  • Christopher J Greenhalgh
  • A Ishikawa
  • C J Phelps
  • Subburaman Mohan
  • Brandon C Sos
  • Sarah M Nordstrom
  • Ethan J Weiss
  • Victoria Florea
  • Bouchra Edderkaoui
  • Apurva K Srivastava
  • David J Baylink
  • Philip J Menagh
  • Robert E Levy
  • Julia C Boughner
  • Satyanaryana Eleswarapu
  • Joshua H Wong
  • Clifford J Rosen
  • Philipp Schneider
  • Juan Pablo Del Rincon
  • Leah Rae Donahue
  • Raul M Luque
  • Naoki Ishimori
  • Michael O Thorner
  • Noreen Majeed
  • Yashoda Sharma
  • Donald Fleenor
  • Weidong Wang
  • Emina Itoh
  • R Gregg Richards
  • Ferenc Obal
  • L A Frohman
  • Hanyu Liang
  • Jamie L Barger
  • E Montecino-Rodriguez
  • Andrew V Schally
  • Claudia O Rodrigues
  • Rosemeire M Kanashiro-Takeuchi
  • Ren Zhi Cai
  • Joshua M Hare
  • Norman L Block
  • Sonia S Majid
  • Jon E Wergedal
  • Chandrasekhar Kesavan
  • J M Bugni
  • K Flurkey
  • Kay Uwe Wagner
  • Charles Harris
  • Jennifer L Tran
  • Patrick Caplazi
  • Milana A B Applegate
  • Maria Febbraio
  • Mercedesz Balazs
  • Malcolm B Lowry
  • S Fang
  • Shoshana Yakar
  • Russell T Turner
  • Brian A Holliday
  • James W Smyth
  • Donald B Jump
  • Jonathan W Dukes
  • M P Foster
  • Urszula T Iwaniec
  • Susan T Lord
  • Carmen P Wong
  • Leon W Browder
  • Virginia M Diewert
  • G L Niermann
  • Stephen Wat
  • Honglin Jiang
  • Brandon Sos
  • Tina S Fong
  • Nathan M Young
  • Benedikt Hallgrimsson
  • Jonathan Dukes
  • Zhiliang Gu
  • Sara E Mason

Detail Information

Publications77

  1. ncbi Sexual dimorphism and growth hormone induction of murine pheromone-binding proteins
    D Johnson
    Centre for Genome Research, University of Edinburgh, UK
    J Mol Endocrinol 14:21-34. 1995
    ..C57BL/6 mice homozygous for the lit mutation are GH deficient and transcribe MUP genes at a level much lower than that obtaining in normal mice of ..
  2. ncbi Molecular basis of the little mouse phenotype and implications for cell type-specific growth
    S C Lin
    Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla 92093 0648
    Nature 364:208-13. 1993
    ..anterior pituitary gland, is the mutation of a single nucleotide that alters Asp 60 to Gly in the growth hormone releasing factor receptor. Detailed analysis of the lit mouse anterior pituitary reveals spatially distinct proliferative ..
  3. ncbi Fine structure of somatotrophs and mammotrophs in the pituitary pars distalis of the little (lit) mutant mouse
    E Christensen
    Virchows Arch B Cell Pathol Incl Mol Pathol 37:89-96. 1981
    The cellular pathology and postnatal differentiation of somatotrophs and mammotrophs in the pars distalis of little (lit/lit) and normal (+/+; lit/+) mice were studied by means of electron microscopy...
  4. ncbi Mammary gland branching morphogenesis is diminished in mice with a deficiency of insulin-like growth factor-I (IGF-I), but not in mice with a liver-specific deletion of IGF-I
    R Gregg Richards
    Hormones and Cancer Group, Laboratory of Molecular Carcinogenesis, National Institute of Environmental and Health Science, P O Box 12233, MD D4 04, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 145:3106-10. 2004
    ..On the basis of these findings, we propose that paracrine, not endocrine, IGF-I is important for mammary branching morphogenesis...
  5. ncbi Primary B cell development is impaired in mice with defects of the pituitary/thyroid axis
    E Montecino-Rodriguez
    Department of Pathology and Laboratory Medicine and the Jonsson Comprehensive Cancer Center, School of Medicine, University of California, Los Angeles 90095, USA
    J Immunol 159:2712-9. 1997
    ..B cell development was normal in Little and IGF-I knockout animals, which have defects in the production of growth hormone and/or insulin-like growth ..
  6. ncbi Regulation of metabolic water and protein compartments by insulin-like growth factor-I and testosterone in growth hormone-deficient lit/lit mice
    L R Donahue
    Jackson Laboratory, Bar Harbor, Maine 04609
    J Endocrinol 139:431-9. 1993
    ..We chose genetically GH-deficient little (lit/lit) mice to test whether these anabolic hormones act independently or in concert with each other to ..
  7. pmc Alterations in xenobiotic metabolism in the long-lived Little mice
    Daniel Amador-Noguez
    Molecular and Human Genetics Department, Baylor College of Medicine, Houston, TX 77030, USA
    Aging Cell 6:453-70. 2007
    Our previous microarray expression analysis of the long-lived Little mice (Ghrhr(lit/lit)) showed a concerted up-regulation of xenobiotic detoxification genes...
  8. ncbi A chemical mutagenesis screen to identify modifier genes that interact with growth hormone and TGF-beta signaling pathways
    Subburaman Mohan
    Musculoskeletal Disease Center, Loma Linda VA Health Care Systems, Loma Linda, CA 92357, USA
    Bone 42:388-95. 2008
    ..We utilized two mutant mouse models: 1) mice carrying a mutation in growth hormone releasing hormone receptor (Ghrhr) (denoted 'lit' allele, Ghrhr(lit)), which results in GH deficiency; and 2) mice lacking ..
  9. ncbi New insights into the regulation of somatotrope function using genetic and transgenic models
    L A Frohman
    Department of Medicine, University of Illinois at Chicago 60612, USA
    Metabolism 45:1-3. 1996
    ..Genetic models of impaired GH secretion include the little (lit) mouse, the dwarf (dw) rat, the fatty (fa) rat, and the high-growth (hg) mouse...
  10. ncbi Gene expression of hypothalamic growth hormone (GH)-releasing hormone and somatostatin does not correlate with pulsatile secretion of GH in the adult mouse
    S Murao
    First Department of Internal Medicine, Kagawa Medical School, Japan
    Res Commun Mol Pathol Pharmacol 89:269-77. 1995
    ..This result suggests that changes in GHRH and SRIH secretion have little association with changes in the synthesis of these peptides at the hypothalamus in the male mouse.
  11. ncbi Sleep in mice with nonfunctional growth hormone-releasing hormone receptors
    Ferenc Obal
    Department of Physiology and Endocrine Unit, University of Szeged, A Szent Györgyi Medical Center, 6720 Szeged, Hungary
    Am J Physiol Regul Integr Comp Physiol 284:R131-9. 2003
    The role of the somatotropic axis in sleep regulation was studied by using the lit/lit mouse with nonfunctional growth hormone (GH)-releasing hormone (GHRH) receptors (GHRH-Rs) and control heterozygous C57BL/6J mice, which have a normal ..
  12. pmc ENU mutation mapped to a distal region of chromosome 11 is a major determinant of bone size
    Bouchra Edderkaoui
    Musculoskeletal Disease Center, Loma Linda VA Health Care Systems, Loma Linda, California
    Physiol Genomics 45:1222-8. 2013
    ..The mutant strain developed in this study provides an important tool to identify a novel mechanosensitive gene that determines bone size during postnatal development. ..
  13. pmc Agonists of growth hormone-releasing hormone stimulate self-renewal of cardiac stem cells and promote their survival
    Victoria Florea
    Interdisciplinary Stem Cell Institute
    Proc Natl Acad Sci U S A 111:17260-5. 2014
    ..These results support the therapeutic use of GHRH-R agonists for stimulating endogenous mechanisms for myocardial repair or for preconditioning of stem cells before transplantation. ..
  14. pmc Ligand-dependent and -independent effects of splice variant 1 of growth hormone-releasing hormone receptor
    Hippokratis Kiaris
    Department of Biological Chemistry, Medical School, University of Athens, 115 27 Athens, Greece
    Proc Natl Acad Sci U S A 100:9512-7. 2003
    ..property of the truncated form of the receptor, because the expression of SV1 and not of the full-length GHRH receptor stimulated the proliferation of 3T3 fibroblasts in the absence of exogenous GHRH, whereas both forms mediated ..
  15. pmc Growth hormone regulates the balance between bone formation and bone marrow adiposity
    Philip J Menagh
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    J Bone Miner Res 25:757-68. 2010
    ..Rather, GH enhances adipocyte as well as osteoblast precursor pool size. However, GH increases osteoblast differentiation while suppressing bone marrow lipid accumulation...
  16. ncbi Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth
    C Lin
    Eukaryotic Regulatory Biology Program, University of California, San Diego
    Nature 360:765-8. 1992
    ..The pituitary hypoplasia in these mice thus appears to be due, at least in part, to the absence of GRF receptor, which is in turn due to the absence of functional Pit-1.
  17. pmc Muscle mechano growth factor is preferentially induced by growth hormone in growth hormone-deficient lit/lit mice
    Keiji Iida
    Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Physiol 560:341-9. 2004
    ..isoforms using transgenic mice that express bovine GH (bGH), GHR gene-disrupted (GHR-/-) mice and GH-deficient lit/lit mice before and after exogenous GH administration...
  18. pmc Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs
    Hippokratis Kiaris
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 99:196-200. 2002
    ..SV1 exhibits the greatest similarity to the pituitary GHRH receptor and is most likely to be functional...
  19. ncbi Regulation of full-length and truncated growth hormone (GH) receptor by GH in tissues of lit/lit or bovine GH transgenic mice
    Keiji Iida
    Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Am J Physiol Endocrinol Metab 287:E566-73. 2004
    ..The lit/lit mice showed a significant decrease of mGHR-fl in liver, no difference of mGHR-fl in muscle, and a significant ..
  20. ncbi Tissue-specific regulation of growth hormone (GH) receptor and insulin-like growth factor-I gene expression in the pituitary and liver of GH-deficient (lit/lit) mice and transgenic mice that overexpress bovine GH (bGH) or a bGH antagonist
    Keiji Iida
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Endocrinology 145:1564-70. 2004
    ..gland and compared the levels with those derived from liver of bovine GH transgenic, GH antagonist transgenic, lit/lit mice, and their respective controls using real-time RT-PCR...
  21. ncbi Genetic mouse models of extended lifespan
    Hanyu Liang
    Department of Physiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MSC 7762, San Antonio, TX 78229 3900, USA
    Exp Gerontol 38:1353-64. 2003
    ..1996, seven genetic mouse models have been reported to show increased lifespan: Ames and Snell dwarf mice, the 'little mouse' (Ghrhr(lit/lit)), mice null for either growth hormone receptor/binding protein (GHR/BP(-/-)) or p66(shc) (..
  22. ncbi The retardation of aging by caloric restriction: its significance in the transgenic era
    Jamie L Barger
    Wisconsin Primate Research Center and Department of Medicine, University of Wisconsin Madison, Madison, WI 53705, USA
    Exp Gerontol 38:1343-51. 2003
    ..In contrast, for nearly all of the genetically abnormal models of lifespan extension, such data are minimal and often unconvincing; additional studies will be required to validate these strains as suitable models for aging research...
  23. ncbi Cutting edge: Requirement for growth hormone-releasing hormone in the development of experimental autoimmune encephalomyelitis
    Hideto Ikushima
    Research Division, Genomic Research Laboratories, Sumitomo Pharmaceuticals, Osaka, Japan
    J Immunol 171:2769-72. 2003
    ..Although GHRH and its receptor (GHRHR) are expressed in leukocytes, physiological function of GHRH in the immune system remains unclear...
  24. ncbi Growth and development of male "little" mice assessed with Parks' theory of feeding and growth
    Rodolfo C Puche
    Laboratorio de Biologia Osea, Facultad de Ciencias Medicas, Rosario, Argentina
    Growth Dev Aging 66:71-8. 2002
    This work was designed to characterize the appetite kinetics and growth of male C57BL/6J (lit) mice. Those variables were assessed with Parks' function of ad libitum feeding and growth...
  25. pmc Linking sister chromatid cohesion and apoptosis: role of Rad21
    Debananda Pati
    Texas Children s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:8267-77. 2002
    ....
  26. ncbi A quantitative genetic analysis of slow-wave sleep in influenza-infected CXB recombinant inbred mice
    L A Toth
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Behav Genet 29:339-48. 1999
    ..Candidate genes for mediation of this phenotype include Ghrhr (growth hormone releasing hormone receptor), Crhr2 (corticotropin releasing hormone receptor 2), and Cd8a (an epitope on cytotoxic T ..
  27. ncbi Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx
    Weidong Wang
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Cell 7:439-53. 2004
    ....
  28. ncbi Roles of the lactogens and somatogens in perinatal and postnatal metabolism and growth: studies of a novel mouse model combining lactogen resistance and growth hormone deficiency
    Donald Fleenor
    Division of Pediatric Endocrinology and Diabetes, Duke University Medical Center, Durham, North Carolina 27710, USA
    Endocrinology 146:103-12. 2005
    ..The model was created by breeding PRL receptor (PRLR)-deficient (knockout) males with GH-deficient (little) females...
  29. ncbi Diurnal variation in growth hormone receptor messenger ribonucleic acid in liver and skeletal muscle of lit/+ and lit/lit mice
    Emina Itoh
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Endocr J 51:529-35. 2004
    ..b>lit/lit (GH deficient) or lit/+ (GH sufficient) mice were fed ad libitum and lights were on between 0600 and 2000...
  30. pmc SOCS2 negatively regulates growth hormone action in vitro and in vivo
    Christopher J Greenhalgh
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research WEHI and the Cooperative Centre for Cellular Growth Factors, Parkville, Victoria, Australia
    J Clin Invest 115:397-406. 2005
    ..Together, the data provide clear evidence that SOCS2 is a negative regulator of GH signaling...
  31. ncbi A germ line mutation that delays prostate cancer progression and prolongs survival in a murine prostate cancer model
    Noreen Majeed
    Lady Davis Institute for Medical Research, Jewish General Hospital and Department of Oncology, McGill University, 3755 Cote Ste Catherine Road, Montreal, Quebec, Canada H3T 1E2
    Oncogene 24:4736-40. 2005
    ..predisposed to prostate cancer (the TRAMP model) to be homozygous for lit, a mutation that inactivates the GHRH receptor (GHRH-R) and reduces circulating levels of GH and IGF-I...
  32. ncbi Mice severely deficient in growth hormone have normal hematopoiesis
    Yashoda Sharma
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Exp Hematol 33:776-83. 2005
    ....
  33. ncbi Quantitative trait loci that determine BMD in C57BL/6J and 129S1/SvImJ inbred mice
    Naoki Ishimori
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 21:105-12. 2006
    BMD is highly heritable; however, little is known about the genes. To identify loci controlling BMD, we conducted a QTL analysis in a (B6 x 129) F2 population of mice...
  34. ncbi Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function
    Raul M Luque
    Section of Endocrinology and Metabolism, Department of Medicine, University of Illinois at Chicago, Illinois, USA
    Endocrinology 147:2754-63. 2006
    ..expression of GH as well as reduced expression of pituitary receptors important for GH synthesis and release [GHRH receptor (DIO only) and the ghrelin receptor (ob/ob and DIO)]...
  35. ncbi Characterization of receptors for growth hormone-releasing hormone in human osteosarcomas and Ewing's sarcomas
    Gabor Halmos
    Department of Biopharmacy, University of Debrecen, School of Pharmacy, H 4032 Debrecen, Hungary
    Int J Oncol 29:463-9. 2006
    ..04 nM. The presence of GH-RH receptors in human bone tumors provides a rationale for new approaches to the therapy of this malignancy based on GH-RH antagonists...
  36. ncbi Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance
    Juan Pablo Del Rincon
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Diabetes 56:1638-46. 2007
    ....
  37. ncbi Ultrastructural properties in cortical bone vary greatly in two inbred strains of mice as assessed by synchrotron light based micro- and nano-CT
    Philipp Schneider
    Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland
    J Bone Miner Res 22:1557-70. 2007
    ..Results in two different mouse strains, C57BL/6J-Ghrhr(lit)/J and C3...
  38. pmc Growth hormone regulation of insulin-like growth factor-I gene expression may be mediated by multiple distal signal transducer and activator of transcription 5 binding sites
    Satyanaryana Eleswarapu
    Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Endocrinology 149:2230-40. 2008
    ....
  39. pmc Accelerated failure time models provide a useful statistical framework for aging research
    William R Swindell
    Departments of Pathology and Geriatrics, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Exp Gerontol 44:190-200. 2009
    ..In addition, from the standpoint of aging research, these statistical approaches have appealing properties and provide valuable tools for the analysis of survivorship data...
  40. pmc Short-faced mice and developmental interactions between the brain and the face
    Julia C Boughner
    Department of Cell Biology and Anatomy, Faculty of Medicine, University of Calgary, Alberta, Canada
    J Anat 213:646-62. 2008
    ....
  41. pmc Increased thrombosis susceptibility and altered fibrin formation in STAT5-deficient mice
    Sarah M Nordstrom
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    Blood 116:5724-33. 2010
    ..This ultimately resulted in accelerated fibrin polymerization and greater thrombosis susceptibility in STAT5-deficient animals...
  42. pmc Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2
    Brandon C Sos
    Cardiovascular Research Institute, UCSF, San Francisco, California 94158 9001, USA
    J Clin Invest 121:1412-23. 2011
    ..Because GH is known to promote lipolysis, we crossed GH-deficient little mice to JAK2L mice, and this rescued the FL phenotype...
  43. ncbi Etiology of growth hormone deficiency in little, Ames, and Snell dwarf mice
    T C Cheng
    Endocrinology 113:1669-78. 1983
    There are three recessive genes (little, Snell, and Ames) which cause dwarfism and GH deficiency in mice...
  44. ncbi The little mutation suppresses DEN-induced hepatocarcinogenesis in mice and abrogates genetic and hormonal modulation of susceptibility
    J M Bugni
    McArdle Laboratory for Cancer Research, University of Wisconsin Medical School, 1400 University Avenue, Madison, WI 53706, USA
    Carcinogenesis 22:1853-62. 2001
    ..We bred the little mutation onto the more susceptible C57BR/cdJ (BR) and C3H/HeJ (C3H) strains to assess the effect of growth hormone ..
  45. ncbi Pituitary hormones as neurotrophic signals: anomalous hypophysiotrophic neuron differentiation in hypopituitary dwarf mice
    C J Phelps
    Department of Anatomy, Tulane University School of Medicine, New Orleans, Louisiana 70112
    Proc Soc Exp Biol Med 206:6-23. 1994
    ..The collective observations indicate that GH and PRL may be regarded as neurotrophic factors for their respective regulatory neurons in the hypothalamus...
  46. ncbi Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4
    L R Donahue
    Jackson Laboratory, Bar Harbor, Maine 04609
    J Endocrinol 136:91-104. 1993
    ..We used a genetic model of GH deficiency, the 'little' (gene symbol lit) mouse, to determine the GH regulation of IGF-I and its insulin-like growth factor-binding ..
  47. ncbi GH-deficient dw/dw rats and lit/lit mice show increased Fos expression in the hypothalamic arcuate nucleus following systemic injection of GH-releasing peptide-6
    S L Dickson
    Laboratory of Neuroendocrinology, Babraham Institute, Cambridge, UK
    J Endocrinol 146:519-26. 1995
    ..administered GHRP-6 induces Fos expression in the arcuate nucleus of GH-deficient animals (dw/dw rats and lit/lit mice)...
  48. ncbi Somatomedin activity in sera of genetically small mice
    S P Nissley
    Horm Metab Res 12:158-64. 1980
    ..Somatomedin activity was low in the sera from growth hormone deficient mice [Snell (dw/dw), Ames (df/df), and little (lit/lit)] whereas somatomedin activity was normal in serum from the pygmy (pg/pg)) mouse, a mutant proposed as a ..
  49. ncbi Analysis of growth hormone genes in mice with genetic defects of growth hormone expression
    J A Phillips
    J Endocrinol 92:405-7. 1982
    Restriction endonuclease analysis of genomic DNA was carried out for three types of dwarf mice (Little, Ames dwarf and Snell dwarf) that have genetic defects in GH expression...
  50. ncbi Mouse mutants as models in endocrine research
    H M Charlton
    Q J Exp Physiol 69:655-76. 1984
    ..As new hormones are isolated and become available for study these mouse mutants may well be useful in delineating physiological functions for natural and pharmacological products.(ABSTRACT TRUNCATED AT 400 WORDS)..
  51. ncbi Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf "little" mouse
    A C Herington
    Endocrinology 112:2032-8. 1983
    ..hGH) and bovine (bGH) GH and ovine PRL (oPRL) has been compared in liver membranes from GH-deficient dwarf "little" mice (lit/lit) and their normal-sized littermates (lit/+)...
  52. ncbi The little (lit) mutation cosegregates with the growth hormone releasing factor receptor on mouse chromosome 6
    S C Chua
    Laboratory of Human Behavior and Metabolism, Rockefeller University, New York, New York 10021
    Mamm Genome 4:555-9. 1993
    ..mRNA by reverse transcription coupled to the polymerase chain reaction showed a greatly diminished level of GRF receptor mRNA in the pituitaries of lit/lit mice as compared with lit/ + controls...
  53. ncbi Receptor-associated resistance to growth hormone-releasing factor in dwarf "little" mice
    J O Jansson
    Science 232:511-2. 1986
    Anterior pituitaries from the dwarf mouse strain "little" did not release growth hormone or accumulate adenosine 3',5'-monophosphate (cyclic AMP) in response to human and rat growth hormone-releasing factor (GRF)...
  54. ncbi Growth hormone and prolactin immunoreactivity in the pituitary gland of postnatal little (lit) mice
    D B Wilson
    Department of Surgery, University of California, San Diego, La Jolla 92093
    Histol Histopathol 1:309-13. 1986
    Homozygous little (lit/lit) mutant mice exhibit a growth lag which is manifested at approximately two weeks postnatally...
  55. ncbi Cloning and characterization of mouse growth hormone-releasing hormone (GRH) complementary DNA: increased GRH messenger RNA levels in the growth hormone-deficient lit/lit mouse
    M A Frohman
    Department of Anatomy, University of California School of Medicine, San Francisco 94143
    Mol Endocrinol 3:1529-36. 1989
    ..Differences between mouse and rat GRH were also found in the amino acid cleavage sites at the 5' and 3' ends of the mature peptide and at the polyadenylation signal.(ABSTRACT TRUNCATED AT 250 WORDS)..
  56. ncbi The effect of the frequency of subcutaneous insulin-like growth factor-1 administration on weight gain in growth hormone deficient mice
    S M Woodall
    Department of Paediatrics, University of Auckland, New Zealand
    Horm Metab Res 23:581-4. 1991
    ..of subcutaneous IGF-1 administration necessary to promote growth we examined the weight gain of male homozygous lit/lit mice in response to either sc. IGF-1 or bovine GH administration...
  57. ncbi Histopathology of the pituitary gland in neonatal little (lit) mutant mice
    D B Wilson
    Department of Surgery, University of California, San Diego, La Jolla 92093
    Histol Histopathol 7:451-5. 1992
    The pituitary gland in the little (lit) mutant mouse was analyzed with respect to the cytoarchitecture of the pars distalis and the volumetric density of immunoreactive growth hormone (GH) cell granules in neonatal lit/lit and normal ..
  58. ncbi Adrenocorticotropic cell distribution in adult and embryonic pituitaries of the little (lit) mutant mouse
    D B Wilson
    Division of Anatomy, School of Medicine, University of California, San Diego, La Jolla 92093
    Anat Embryol (Berl) 186:347-53. 1992
    ..ACTH) cells and their ultrastructural relationship with growth hormone (GH) cells in adult and 17-day embryonic little (lit/lit) mice that exhibit GH cell defects...
  59. ncbi Inherited ateliotic dwarfism in mice. Characteristics of the mutation, little, on chromosome 6
    E M Eicher
    J Hered 67:87-91. 1976
    A new autosomal recessive mutation in the mouse, little (lit), has been shown to be located on Chromosome 6. The mutation in the homozygous state causes ateliotic dwarfism that is first detected at 15 days of age by decreased body weight...
  60. ncbi Interactions of gender, growth hormone, and phenobarbital induction on murine Cyp2b expression
    M C Sharma
    Laboratories of Biochemistry, University of Pennsylvania School of Veterinary Medicine, Philadelphia 19104 6048, USA
    Biochem Pharmacol 56:1251-8. 1998
    ..induction on Cyp2b expression were examined in phenotypically normal (lit/+) and growth-hormone deficient "little" (lit/lit) mice...
  61. pmc Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
    K Flurkey
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 98:6736-41. 2001
    ..In contrast, homozygosity for the Ghrhr(lit) mutation, which like the Pit1(dw) mutation lowers plasma growth hormone levels, does lead to a significant ..
  62. ncbi Humoral and cell-mediated immunity in mice with genetic deficiencies of prolactin, growth hormone, insulin-like growth factor-I, and thyroid hormone
    M P Foster
    Department of Pathology and Laboratory Medicine 173216, School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    Clin Immunol 96:140-9. 2000
    ..When considered in this context, it is possible to reconcile the contradictory data...
  63. ncbi Stimulation of growth in the little mouse
    W H Beamer
    J Endocrinol 71:37-45. 1976
    The new mouse mutation little (lit) in the homozygous state causes a pituitary deficiency involving at least growth hormone (GH) and prolactin...
  64. ncbi Development of a transgenic mouse that overexpresses a novel product of the growth hormone-releasing hormone gene
    S Fang
    Department of Pediatrics, Indiana University School of Medicine, Indianapolis 46202, USA
    Endocrinology 141:1377-83. 2000
    ....
  65. ncbi Role of growth hormone in the genetic change of mice divergently selected for body weight and fatness
    L Bunger
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Genet Res 74:351-60. 1999
    ..GH deficiency was achieved by repeated backcrossing into each line a recessive mutant gene (lit) which has a defective GH releasing factor receptor...
  66. ncbi The mutant growth hormone-releasing hormone (GHRH) receptor of the little mouse does not bind GHRH
    B D Gaylinn
    Department of Medicine, University of Virginia, Charlottesville 22908, USA
    Endocrinology 140:5066-74. 1999
    ..The defect has been mapped to a missense mutation in the GHRH receptor gene that abolishes the function of the receptor, but the mechanism of this inactivation is unknown...
  67. ncbi Molecular, morphometric and functional analyses demonstrate that the growth hormone deficient little mouse is not hypomyelinated
    D M Lehman
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, TX 78284 7762, USA
    Brain Res Dev Brain Res 116:191-9. 1999
    ..occurring growth hormone deficiency type I on CNS myelination, we compared the myelination of brains from little and wild-type littermate mice using molecular, histological, morphometric, and functional analyses...
  68. ncbi Growth hormone and insulin-like growth factor-I enhance beta-glucuronidase gene activation by androgen in mouse kidney
    G L Niermann
    Children s Hospital Oakland Research Institute, CA 94609, USA
    Mol Cell Endocrinol 153:47-55. 1999
    ..We conclude that GH enhances the effect of androgen on the GUS gene via IGF-I. Using transgenic mice, we have also identified a genetic variant of the GUS gene that is insensitive to GH enhancement of the androgen effect...
  69. ncbi GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function
    P Godfrey
    Department of Biochemistry, Northwestern University, Evanston, Illinois 60208
    Nat Genet 4:227-32. 1993
    ..We report that the Ghrhr gene is located in the middle of mouse chromosome 6 in the same region as the little mutation. Mice homozygous for this mutation have reduced GH secretion and a dwarf phenotype...
  70. ncbi Mapping of three members of the mouse protein disulfide isomerase family
    V Briquet-Laugier
    Lipid Research Laboratory, West Los Angeles Veterans Administration Medical Center, Los Angeles, California 90073, USA
    Mamm Genome 9:176-7. 1998
  71. ncbi Growth hormone physiology in health and disease: insights using genetic and transgenic models
    L A Frohman
    Department of Medicine, University of Illinois at Chicago 60612, USA
    J Pediatr Endocrinol Metab 9:233-6. 1996
  72. ncbi Localization of mouse peroxisome proliferator-activated receptor gamma on chromosome 6
    K Reue
    Lipid Research Laboratory, West Los Angeles VA Medical Center, Building 113, Room 312, 11301 Wilshire Blvd, Los Angeles, California 90073 USA
    Mamm Genome 7:390-1. 1996
  73. ncbi Isolated growth hormone deficiency: testing the little mouse hypothesis in man and exclusion of mutations within the extracellular domain of the growth hormone-releasing hormone receptor
    Y Cao
    Department of Paediatrics, Inselspital, CH 3010 Bern, Switzerland
    Pediatr Res 38:962-6. 1995
    ..Therefore, the GHRH receptor is a reasonable candidate gene for causing IGHD in humans...
  74. ncbi Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse
    M P Wajnrajch
    Children s Clinical Research Center, New York Hospital Cornell Medical Center, New York 10021, USA
    Nat Genet 12:88-90. 1996
  75. ncbi Spatial learning during the course of autoimmune disease in MRL mice
    B Sakic
    Department of Biomedical Sciences, McMaster University, Hamilton, Ont, Canada
    Behav Brain Res 54:57-66. 1993
    ....
  76. ncbi Mapping major quantitative trait loci for postnatal growth in an intersubspecific backcross between C57BL/6J and Philippine wild mice by using principal component analysis
    Akira Ishikawa
    Laboratory of Animal Genetics, Division of Applied Genetics and Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Aichi, Japan
    Genes Genet Syst 79:27-39. 2004
    ..These results suggest that the identified 13 QTLs, most of which affected the entire growth process, are very important contributors to complex genetic networks of postnatal growth...
  77. pmc Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns
    Joshua H Wong
    Cardiovascular Research Institute, Department of Medicine, Division of Cardiology, UCSF, San Francisco, California 94143 0124, USA
    J Clin Invest 118:2969-78. 2008
    ..GH-deficient little (lit) mice were protected from thrombosis, and pulsatile GH given to lit mice restored the male clotting phenotype...

Research Grants6

  1. GROWTH HORMONE RELEASING FACTOR RECEPTOR
    Bruce Gaylinn; Fiscal Year: 2001
    ..An improved understanding of GHRH receptor structure, function, physiology and regulation will reveal the information needed to facilitate clinical and ..
  2. Facility renovation to expand mouse barrier space
    LINDA TOTH; Fiscal Year: 2005
    ..This space will not be adequate to support our anticipated continued growth in the areas of infectious disease and toxic challenge and in the need for quarantine of non-vendor rodents. ..
  3. ANALGESIC REGIMENS FOR SURGERY AND INFLAMMATION IN MICE
    LINDA TOTH; Fiscal Year: 2006
    ..The data should reveal new and practical strategies for relief of post-procedural pain in mice. ..
  4. BEHAVIORAL AND PHYSIOLOGIC PATHOBIOLOGY OF MICE
    LINDA TOTH; Fiscal Year: 2006
    ..abstract_text> ..
  5. Sleep and fatigue during renal disease in mice
    LINDA TOTH; Fiscal Year: 2008
    ..Achieving this ambitious goal is feasible given the experience of my laboratory in surveying sleep phenotypes in other studies involving large numbers of mice. [unreadable] [unreadable]..