Ggamma13

Summary

Gene Symbol: Ggamma13
Description: guanine nucleotide binding protein (G protein), gamma 13
Alias: 1500031D04Rik, AB030194, Ggamma13, guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
Species: mouse
Products:     Ggamma13

Top Publications

  1. Huang L, Shanker Y, Dubauskaite J, Zheng J, Yan W, Rosenzweig S, et al. Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium. Nat Neurosci. 1999;2:1055-62 pubmed
    ..We identified a G-protein gamma subunit (Ggamma13) that colocalized with alpha-gustducin in taste receptor cells...
  2. Ota M, Kaneko Y, Kondo K, Ogishima S, Tanaka H, Eto K, et al. Combined in silico and in vivo analyses reveal role of Hes1 in taste cell differentiation. PLoS Genet. 2009;5:e1000443 pubmed publisher
    ..Thus, according to our composite analyses, Hes1 is likely to play a role in orchestrating taste cell differentiation in developing taste buds. ..
  3. Blake B, Wing M, Zhou J, Lei Q, Hillmann J, Behe C, et al. G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13). J Biol Chem. 2001;276:49267-74 pubmed
  4. Prandi S, Bromke M, Hübner S, Voigt A, Boehm U, Meyerhof W, et al. A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131. PLoS ONE. 2013;8:e82820 pubmed publisher
    ..Expression in colonic goblet cells is consistent with a role of Tas2rs in defense mechanisms against potentially harmful xenobiotics. ..
  5. Challis R, Tian H, Wang J, He J, Jiang J, Chen X, et al. An Olfactory Cilia Pattern in the Mammalian Nose Ensures High Sensitivity to Odors. Curr Biol. 2015;25:2503-12 pubmed publisher
    ..These findings reveal an intrinsically programmed configuration in the nose to ensure high sensitivity to odors. ..
  6. Huang L, Max M, Margolskee R, Su H, Masland R, Euler T. G protein subunit G gamma 13 is coexpressed with G alpha o, G beta 3, and G beta 4 in retinal ON bipolar cells. J Comp Neurol. 2003;455:1-10 pubmed
    We investigated the expression of Ggamma13, a recently discovered G protein subunit, and a selection of Gbeta subunits in retinal bipolar cells, by using a transgenic mouse strain in which green fluorescent protein is strongly expressed ..
  7. Li Z, Benard O, Margolskee R. Ggamma13 interacts with PDZ domain-containing proteins. J Biol Chem. 2006;281:11066-73 pubmed
    The G protein gamma13 subunit (Ggamma13) is expressed in taste and retinal and neuronal tissues and plays a key role in taste transduction...
  8. Ramakrishnan H, Dhingra A, Tummala S, Fina M, Li J, Lyubarsky A, et al. Differential function of Gγ13 in rod bipolar and ON cone bipolar cells. J Physiol. 2015;593:1531-50 pubmed publisher
  9. Li F, Zhou M. Depletion of bitter taste transduction leads to massive spermatid loss in transgenic mice. Mol Hum Reprod. 2012;18:289-97 pubmed publisher
    ..The entire taste transduction cascade (?-gustducin, Ggamma13, phospholipase C?2) was detected in spermatogenesis, whereas transient receptor potential, cation channel ..

More Information

Publications14

  1. Tummala S, Neinstein A, Fina M, Dhingra A, Vardi N. Localization of Cacna1s to ON bipolar dendritic tips requires mGluR6-related cascade elements. Invest Ophthalmol Vis Sci. 2014;55:1483-92 pubmed publisher
    ..We hypothesize that Cacna1s contributes to light adaptation by permeating calcium. ..
  2. Fujino A, Pieretti Vanmarcke R, Wong A, Donahoe P, Arango N. Sexual dimorphism of G-protein subunit Gng13 expression in the cortical region of the developing mouse ovary. Dev Dyn. 2007;236:1991-6 pubmed
    ..Here, we report that, in the developing mouse embryo, expression of Gng13 mRNA is highly restricted to the cortex of the XX gonad during sexual differentiation, suggesting a role for this gene during ovarian development. ..
  3. Kerr D, Von Dannecker L, Davalos M, Michaloski J, Malnic B. Ric-8B interacts with G alpha olf and G gamma 13 and co-localizes with G alpha olf, G beta 1 and G gamma 13 in the cilia of olfactory sensory neurons. Mol Cell Neurosci. 2008;38:341-8 pubmed publisher
    ..Here we show that Ric-8B also interacts with Ggamma13, a divergent member of the Ggamma subunit family which has been implicated in taste signal transduction, and is ..
  4. Layman W, McEwen D, Beyer L, Lalani S, Fernbach S, Oh E, et al. Defects in neural stem cell proliferation and olfaction in Chd7 deficient mice indicate a mechanism for hyposmia in human CHARGE syndrome. Hum Mol Genet. 2009;18:1909-23 pubmed publisher
    ..These studies provide evidence that mammalian olfactory dysfunction due to Chd7 haploinsufficiency is linked to primary defects in olfactory neural stem cell proliferation and may influence olfactory bulb development. ..
  5. Li F, Ponissery Saidu S, Yee K, Wang H, Chen M, Iguchi N, et al. Heterotrimeric G protein subunit G?13 is critical to olfaction. J Neurosci. 2013;33:7975-84 pubmed publisher
    ..The identification of the olfactory G-protein's ?? moiety has provided a novel approach to understanding the feedback regulation of olfactory signal transduction pathways as well as the control of subcellular structures of OSNs. ..