Gfi1

Summary

Gene Symbol: Gfi1
Description: growth factor independent 1
Alias: AW495828, Gfi-1, Pal-1, Pal1, zinc finger protein Gfi-1, growth factor independent protein 1
Species: mouse
Products:     Gfi1

Top Publications

  1. Pargmann D, Yücel R, Kosan C, Saba I, Klein Hitpass L, Schimmer S, et al. Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function. Eur J Immunol. 2007;37:3551-63 pubmed
    The transcriptional repressor Gfi1 is a nuclear zinc-finger protein that is expressed in T cell precursors in the thymus, but is down-regulated in mature, resting T cells...
  2. Zhuang D, Qiu Y, Kogan S, Dong F. Increased CCAAT enhancer-binding protein epsilon (C/EBPepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia. J Biol Chem. 2006;281:10745-51 pubmed
  3. Ordoñez Rueda D, Jönsson F, Mancardi D, Zhao W, Malzac A, Liang Y, et al. A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia. Eur J Immunol. 2012;42:2395-408 pubmed publisher
    ..form of neutropenia resulting from a point mutation in the transcriptional repressor Growth Factor Independence 1 (Gfi1)...
  4. Bjerknes M, Cheng H. Cell Lineage metastability in Gfi1-deficient mouse intestinal epithelium. Dev Biol. 2010;345:49-63 pubmed publisher
    ..Various tissues of mice and men with defects in the zinc-finger transcriptional repressor Gfi1 have dramatic perturbations in the proportions of their differentiated cell types...
  5. Park J, Yu Q, Erman B, Appelbaum J, Montoya Durango D, Grimes H, et al. Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity. 2004;21:289-302 pubmed
    ..different molecular mechanisms in CD4+ and CD8+ T cells, as CD8+ T cells utilize the transcriptional repressor GFI1 while CD4+ T cells do not...
  6. Spooner C, Cheng J, Pujadas E, Laslo P, Singh H. A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates. Immunity. 2009;31:576-86 pubmed publisher
    ..We demonstrated that Gfi1 reciprocally promoted B cell fate choice at the expense of myeloid progeny...
  7. Doan L, Porter S, Duan Z, Flubacher M, Montoya D, Tsichlis P, et al. Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells. Nucleic Acids Res. 2004;32:2508-19 pubmed
    Growth factor independence-1 (GFI1) and GFI1B are closely related, yet differentially expressed transcriptional repressors with nearly identical DNA binding domains...
  8. Gregorieff A, Stange D, Kujala P, Begthel H, van den Born M, Korving J, et al. The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium. Gastroenterology. 2009;137:1333-45.e1-3 pubmed publisher
    ..In this study, we investigated the role of the Wnt-responsive, Ets-domain transcription factor Spdef in the differentiation of goblet and Paneth cells...
  9. Wallis D, Hamblen M, Zhou Y, Venken K, Schumacher A, Grimes H, et al. The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development. 2003;130:221-32 pubmed
    b>Gfi1 was first identified as causing interleukin 2-independent growth in T cells and lymphomagenesis in mice. Much work has shown that Gfi1 and Gfi1b, a second mouse homolog, play pivotal roles in blood cell lineage differentiation...
  10. Khandanpour C, Phelan J, Vassen L, Schütte J, Chen R, Horman S, et al. Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia. Cancer Cell. 2013;23:200-14 pubmed publisher
    ..We show here that growth factor independence 1 (Gfi1) can serve such a function because Gfi1 ablation exacerbates p53 responses and lowers the threshold for p53-induced ..

Detail Information

Publications77

  1. Pargmann D, Yücel R, Kosan C, Saba I, Klein Hitpass L, Schimmer S, et al. Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function. Eur J Immunol. 2007;37:3551-63 pubmed
    The transcriptional repressor Gfi1 is a nuclear zinc-finger protein that is expressed in T cell precursors in the thymus, but is down-regulated in mature, resting T cells...
  2. Zhuang D, Qiu Y, Kogan S, Dong F. Increased CCAAT enhancer-binding protein epsilon (C/EBPepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia. J Biol Chem. 2006;281:10745-51 pubmed
  3. Ordoñez Rueda D, Jönsson F, Mancardi D, Zhao W, Malzac A, Liang Y, et al. A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia. Eur J Immunol. 2012;42:2395-408 pubmed publisher
    ..form of neutropenia resulting from a point mutation in the transcriptional repressor Growth Factor Independence 1 (Gfi1)...
  4. Bjerknes M, Cheng H. Cell Lineage metastability in Gfi1-deficient mouse intestinal epithelium. Dev Biol. 2010;345:49-63 pubmed publisher
    ..Various tissues of mice and men with defects in the zinc-finger transcriptional repressor Gfi1 have dramatic perturbations in the proportions of their differentiated cell types...
  5. Park J, Yu Q, Erman B, Appelbaum J, Montoya Durango D, Grimes H, et al. Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival. Immunity. 2004;21:289-302 pubmed
    ..different molecular mechanisms in CD4+ and CD8+ T cells, as CD8+ T cells utilize the transcriptional repressor GFI1 while CD4+ T cells do not...
  6. Spooner C, Cheng J, Pujadas E, Laslo P, Singh H. A recurrent network involving the transcription factors PU.1 and Gfi1 orchestrates innate and adaptive immune cell fates. Immunity. 2009;31:576-86 pubmed publisher
    ..We demonstrated that Gfi1 reciprocally promoted B cell fate choice at the expense of myeloid progeny...
  7. Doan L, Porter S, Duan Z, Flubacher M, Montoya D, Tsichlis P, et al. Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells. Nucleic Acids Res. 2004;32:2508-19 pubmed
    Growth factor independence-1 (GFI1) and GFI1B are closely related, yet differentially expressed transcriptional repressors with nearly identical DNA binding domains...
  8. Gregorieff A, Stange D, Kujala P, Begthel H, van den Born M, Korving J, et al. The ets-domain transcription factor Spdef promotes maturation of goblet and paneth cells in the intestinal epithelium. Gastroenterology. 2009;137:1333-45.e1-3 pubmed publisher
    ..In this study, we investigated the role of the Wnt-responsive, Ets-domain transcription factor Spdef in the differentiation of goblet and Paneth cells...
  9. Wallis D, Hamblen M, Zhou Y, Venken K, Schumacher A, Grimes H, et al. The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development. 2003;130:221-32 pubmed
    b>Gfi1 was first identified as causing interleukin 2-independent growth in T cells and lymphomagenesis in mice. Much work has shown that Gfi1 and Gfi1b, a second mouse homolog, play pivotal roles in blood cell lineage differentiation...
  10. Khandanpour C, Phelan J, Vassen L, Schütte J, Chen R, Horman S, et al. Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia. Cancer Cell. 2013;23:200-14 pubmed publisher
    ..We show here that growth factor independence 1 (Gfi1) can serve such a function because Gfi1 ablation exacerbates p53 responses and lowers the threshold for p53-induced ..
  11. Rathinam C, Geffers R, Yücel R, Buer J, Welte K, Moroy T, et al. The transcriptional repressor Gfi1 controls STAT3-dependent dendritic cell development and function. Immunity. 2005;22:717-28 pubmed
    ..Using a transcriptional profiling approach, we identified Gfi1 as a novel critical transcription factor in DC differentiation...
  12. Kiernan A, Pelling A, Leung K, Tang A, Bell D, Tease C, et al. Sox2 is required for sensory organ development in the mammalian inner ear. Nature. 2005;434:1031-5 pubmed
  13. Saleque S, Kim J, Rooke H, Orkin S. Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol Cell. 2007;27:562-72 pubmed
    ..Lineage-restricted deployment of these cofactors through interaction with Gfi proteins controls hematopoietic differentiation. ..
  14. Hertzano R, Montcouquiol M, Rashi Elkeles S, Elkon R, Yücel R, Frankel W, et al. Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene. Hum Mol Genet. 2004;13:2143-53 pubmed
    ..mice using a high density oligonucleotide microarray, we identified the gene encoding growth factor independence 1 (Gfi1) as a likely in vivo target gene regulated by Pou4f3...
  15. Zhu J, Guo L, Min B, Watson C, Hu Li J, Young H, et al. Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation. Immunity. 2002;16:733-44 pubmed
    ..The synergy of Gfi-1 and Gata3 provides a mechanism through which IL-4 could selectively promote Th2 cell expansion. ..
  16. Karsunky H, Zeng H, Schmidt T, Zevnik B, Kluge R, Schmid K, et al. Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Nat Genet. 2002;30:295-300 pubmed
    The transcriptional repressor Gfi1 is a nuclear zinc-finger protein expressed in T-cell precursors in the thymus and in activated mature T lymphocytes...
  17. Zarebski A, Velu C, Baktula A, Bourdeau T, Horman S, Basu S, et al. Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1. Immunity. 2008;28:370-80 pubmed publisher
    ..The growth factor independent-1 (GFI1) transcription factor regulates ELA2...
  18. Rodel B, Tavassoli K, Karsunky H, Schmidt T, Bachmann M, Schaper F, et al. The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3. EMBO J. 2000;19:5845-55 pubmed
  19. Yang H, Gan J, Xie X, Deng M, Feng L, Chen X, et al. Gfi1-Cre knock-in mouse line: A tool for inner ear hair cell-specific gene deletion. Genesis. 2010;48:400-6 pubmed publisher
    b>Gfi1 encodes a zinc-finger transcription factor essential for the development and maintenance of haematopoiesis and the inner ear. In mouse inner ear, Gfi1 expression is confined to hair cells during development and in adulthood...
  20. Scheijen B, Jonkers J, Acton D, Berns A. Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice. J Virol. 1997;71:9-16 pubmed
    ..This finding suggests that Bmi-1 and Gfi-1 belong to the same complementation group in lymphoid transformation. ..
  21. Schulz D, Vassen L, Chow K, McWhirter S, Amin R, Moroy T, et al. Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1. J Exp Med. 2012;209:187-99 pubmed publisher
    ..primary cells, transcription of Gfi1b inversely correlates with Rag transcription, and simultaneous inactivation of Gfi1 and Gfi1b leads to an increase in Rag transcription early in B cell development...
  22. Noah T, Kazanjian A, Whitsett J, Shroyer N. SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells. Exp Cell Res. 2010;316:452-65 pubmed publisher
    ..These data support a model in which Spdef promotes terminal differentiation into goblet cells of a common goblet/Paneth progenitor. ..
  23. Horman S, Velu C, Chaubey A, Bourdeau T, Zhu J, Paul W, et al. Gfi1 integrates progenitor versus granulocytic transcriptional programming. Blood. 2009;113:5466-75 pubmed publisher
    In patients with severe congenital neutropenia (SCN) and mice with growth factor independent-1 (Gfi1) loss of function, arrested myeloid progenitors accumulate, whereas terminal granulopoiesis is blocked...
  24. D Souza S, Del Prete D, Jin S, Sun Q, Huston A, Kostov F, et al. Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease. Blood. 2011;118:6871-80 pubmed publisher
    ..We found that BMSCs from both MM-bearing mice and MM patients had increased levels of the transcriptional repressor Gfi1 compared with controls and that Gfi1 was a novel transcriptional repressor of the critical OB transcription factor ..
  25. Dahl R, Iyer S, Owens K, Cuylear D, Simon M. The transcriptional repressor GFI-1 antagonizes PU.1 activity through protein-protein interaction. J Biol Chem. 2007;282:6473-83 pubmed
    ..Our data demonstrate that GFI-1 represses PU.1 activity and that lack of this repression in Gfi-1(-/-) myeloid cells contributes to the observed mixed lineage phenotype. ..
  26. Khandanpour C, Krongold J, Schütte J, Bouwman F, Vassen L, Gaudreau M, et al. The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice. Blood. 2012;120:4006-17 pubmed publisher
    The coding single nucleotide polymorphism GFI136N in the human gene growth factor independence 1 (GFI1) is present in 3%-7% of whites and increases the risk for acute myeloid leukemia (AML) by 60%...
  27. Vassen L, Okayama T, Moroy T. Gfi1b:green fluorescent protein knock-in mice reveal a dynamic expression pattern of Gfi1b during hematopoiesis that is largely complementary to Gfi1. Blood. 2007;109:2356-64 pubmed
    Gfi1b and Gfi1 are 37- and 55-kDa transcriptional repressors that share common features such as a 20-amino acid (aa) N-terminal SNAG domain, a nonconserved intermediary domain, and 6 highly conserved C-terminal zinc fingers...
  28. Gilks C, Bear S, Grimes H, Tsichlis P. Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein. Mol Cell Biol. 1993;13:1759-68 pubmed
    ..In agreement with this, Gfi-1 does not induce the expression of IL-2. Expression of Gfi-1 in 2780d cells following transfer of a Gfi-1/LXSN retrovirus construct contributes to the emergence of the IL-2i phenotype. ..
  29. Grimes H, Gilks C, Chan T, Porter S, Tsichlis P. The Gfi-1 protooncoprotein represses Bax expression and inhibits T-cell death. Proc Natl Acad Sci U S A. 1996;93:14569-73 pubmed
    ..Therefore, Gfi-1 may inhibit apoptosis by means of its repression of multiple proapoptotic regulators. The antiapoptotic properties of Gfi-1 provide a potential explanation for its strong collaboration with c-myc during oncogenesis. ..
  30. Hock H, Hamblen M, Rooke H, Traver D, Bronson R, Cameron S, et al. Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity. 2003;18:109-20 pubmed
    ..Thus, Gfi-1 not only promotes differentiation of neutrophils but also antagonizes traits of the alternate monocyte/macrophage program. ..
  31. Zörnig M, Schmidt T, Karsunky H, Grzeschiczek A, Moroy T. Zinc finger protein GFI-1 cooperates with myc and pim-1 in T-cell lymphomagenesis by reducing the requirements for IL-2. Oncogene. 1996;12:1789-801 pubmed
    ..Our data suggest that gfi-1 is a proto-oncogene cooperation with both myc and pim-1 genes in T-cell lymphomagenesis. ..
  32. Khandanpour C, Kosan C, Gaudreau M, Duhrsen U, Hébert J, Zeng H, et al. Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease. Stem Cells. 2011;29:376-85 pubmed publisher
    ..The transcriptional repressor growth factor independence 1 (Gfi1) restricts HSC proliferation and is essential to maintain their self-renewal capacity and multipotency after ..
  33. Zhu J, Jankovic D, Grinberg A, Guo L, Paul W. Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion. Proc Natl Acad Sci U S A. 2006;103:18214-9 pubmed
    ..Using conditionally Gfi1-deficient mice prepared for this study, we show that in vitro or in vivo deletion of this factor dramatically ..
  34. Hock H, Hamblen M, Rooke H, Schindler J, Saleque S, Fujiwara Y, et al. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature. 2004;431:1002-7 pubmed
    ..Thus, Gfi-1 is essential to restrict HSC proliferation and to preserve HSC functional integrity. ..
  35. Zweidler McKay P, Grimes H, Flubacher M, Tsichlis P. Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor. Mol Cell Biol. 1996;16:4024-34 pubmed
    ..These results suggest that Gfi-1 may play a role in HCMV biology and may contribute to oncogenesis and T-cell activation by repressing the expression of genes that inhibit these processes. ..
  36. Schmidt T, Zörnig M, Beneke R, Moroy T. MoMuLV proviral integrations identified by Sup-F selection in tumors from infected myc/pim bitransgenic mice correlate with activation of the gfi-1 gene. Nucleic Acids Res. 1996;24:2528-34 pubmed
  37. Khandanpour C, Sharif Askari E, Vassen L, Gaudreau M, Zhu J, Paul W, et al. Evidence that growth factor independence 1b regulates dormancy and peripheral blood mobilization of hematopoietic stem cells. Blood. 2010;116:5149-61 pubmed publisher
    ..Finally, the additional deletion of the related Gfi1 gene in Gfi1b(ko/ko) HSCs is incompatible with the maintenance of HSCs, suggesting that Gfi1b and Gfi1 have ..
  38. Sato T, van Es J, Snippert H, Stange D, Vries R, van den Born M, et al. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature. 2011;469:415-8 pubmed publisher
    ..In colon crypts, CD24(+) cells residing between Lgr5 stem cells may represent the Paneth cell equivalents. We conclude that Lgr5 stem cells compete for essential niche signals provided by a specialized daughter cell, the Paneth cell...
  39. Grimes H, Chan T, Zweidler McKay P, Tong B, Tsichlis P. The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal. Mol Cell Biol. 1996;16:6263-72 pubmed
    ..Induction of Gfi-1 may therefore contribute to T-cell activation and tumor progression by repressing the expression of genes that inhibit cellular proliferation. ..
  40. Yücel R, Karsunky H, Klein Hitpass L, Moroy T. The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus. J Exp Med. 2003;197:831-44 pubmed
    ..Here we identify the transcriptional repressor Gfi1 as an important regulator of this maturation process...
  41. Yücel R, Kosan C, Heyd F, Moroy T. Gfi1:green fluorescent protein knock-in mutant reveals differential expression and autoregulation of the growth factor independence 1 (Gfi1) gene during lymphocyte development. J Biol Chem. 2004;279:40906-17 pubmed
    The Gfi1 gene encodes a 55-kDa transcriptional repressor protein with important functions in T-cell development, in granulopoiesis, and in the regulation of the innate immune response...
  42. Zeng H, Yücel R, Kosan C, Klein Hitpass L, Moroy T. Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J. 2004;23:4116-25 pubmed
    ..We show here that the transcription factor Gfi1 is expressed in HSCs and in more mature cells such as common lymphoid progenitors (CLPs) and granulo/monocytic ..
  43. Fiolka K, Hertzano R, Vassen L, Zeng H, Hermesh O, Avraham K, et al. Gfi1 and Gfi1b act equivalently in haematopoiesis, but have distinct, non-overlapping functions in inner ear development. EMBO Rep. 2006;7:326-33 pubmed
    b>Gfi1 is a transcriptional repressor essential for haematopoiesis and inner ear development...
  44. Vassen L, Fiolka K, Moroy T. Gfi1b alters histone methylation at target gene promoters and sites of gamma-satellite containing heterochromatin. EMBO J. 2006;25:2409-19 pubmed
    ..We propose that Gfi1b functions in heterochromatin formation and silencing of euchromatic transcription by recruiting histone methyl transferases to either gamma-satellite sequences or specific target gene promoters. ..
  45. Velu C, Baktula A, Grimes H. Gfi1 regulates miR-21 and miR-196b to control myelopoiesis. Blood. 2009;113:4720-8 pubmed publisher
    The zinc finger protein growth factor independent-1 (Gfi1) is a transcriptional repressor that is critically required for normal granulocytic differentiation...
  46. Lancrin C, Mazan M, Stefanska M, Patel R, Lichtinger M, Costa G, et al. GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment. Blood. 2012;120:314-22 pubmed publisher
    ..Here, we report the identification of Gfi1 and Gfi1b as direct targets of RUNX1 and critical regulators of EHT...
  47. Hertzano R, Dror A, Montcouquiol M, Ahmed Z, Ellsworth B, Camper S, et al. Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system. Eur J Neurosci. 2007;25:999-1005 pubmed
    ..This is the first example of a hair cell-specific gene expressed both in auditory and in vestibular hair cells, with differential regulation of expression in these two closely related systems. ..
  48. Suzuki J, Maruyama S, Tamauchi H, Kuwahara M, Horiuchi M, Mizuki M, et al. Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells. Immunology. 2016;147:476-87 pubmed publisher
    A transcriptional repressor Gfi1 promotes T helper type 2 (Th2) cell development and inhibits Th17 and inducible regulatory T-cell differentiation...
  49. Munnamalai V, Hayashi T, Bermingham McDonogh O. Notch prosensory effects in the Mammalian cochlea are partially mediated by Fgf20. J Neurosci. 2012;32:12876-84 pubmed publisher
    ..Addition of exogenous FGF20 compensated for the block in Notch signaling and rescued Sox2, a prosensory marker, and Gfi1, an early hair cell marker in explant cultures...
  50. Hamard P, Barthelery N, Hogstad B, Mungamuri S, Tonnessen C, Carvajal L, et al. The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo. Genes Dev. 2013;27:1868-85 pubmed publisher
    ..Thus, the C terminus of p53 regulates gene expression via multiple mechanisms depending on the tissue and target, and this leads to specific phenotypic effects in vivo. ..
  51. Vo B, Li C, Morgan M, Theurillat I, Finkelstein D, Wright S, et al. Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma. Cell Rep. 2017;18:2907-2917 pubmed publisher
    ..Candidate oncogenic drivers suppressed by Ezh2 included Gfi1, a proto-oncogene frequently activated in human G3 MBs...
  52. Jin J, Zeng H, Schmid K, Toetsch M, Uhlig S, Moroy T. The zinc finger protein Gfi1 acts upstream of TNF to attenuate endotoxin-mediated inflammatory responses in the lung. Eur J Immunol. 2006;36:421-30 pubmed
    b>Gfi1 is a 55-kD nuclear zinc finger protein that is differentially expressed in lymphoid and myeloid cells. Gfi1(-/-) mice show a very strong systemic response to the endotoxin LPS and die rapidly within 36 h with symptoms of septic shock...
  53. Dabrowska M, Dybkaer K, Johnsen H, Wang B, Wabl M, Pedersen F. Loss of MicroRNA targets in the 3' untranslated region as a mechanism of retroviral insertional activation of growth factor independence 1. J Virol. 2009;83:8051-61 pubmed publisher
    ..identified the genomic region carrying the transcriptional repressor and oncogene growth factor independence 1 (Gfi1) as a frequent target for SL3-3 in the NMRI-i mouse genome...
  54. Zhu J, Davidson T, Wei G, Jankovic D, Cui K, Schones D, et al. Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells. J Exp Med. 2009;206:329-41 pubmed publisher
    ..In Gfi1(-/-) Th2 cells, the Rorc, Il23r, and Cd103 loci showed histone 3 lysine 4 trimethylation modifications that were ..
  55. Fraszczak J, Helness A, Chen R, Vadnais C, Robert F, Khandanpour C, et al. Threshold Levels of Gfi1 Maintain E2A Activity for B Cell Commitment via Repression of Id1. PLoS ONE. 2016;11:e0160344 pubmed publisher
    ..fate in hematopoietic progenitors has been proposed, in which a network of the transcription factors Egr1/2, Nab, Gfi1 and PU.1 forms the core element...
  56. Desnues B, Macedo A, Ordoñez Rueda D, Roussel Queval A, Malissen B, Bruhns P, et al. The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling. Eur J Immunol. 2016;46:2801-2811 pubmed publisher
    The transcriptional repressor growth factor independence 1 (Gfi1) is important in myeloid and lymphoid differentiation. In the current study we evaluated the involvement of Gfi1 in systemic lupus erythematosus (SLE)...
  57. De La Luz Sierra M, Gasperini P, McCormick P, Zhu J, Tosato G. Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells. Blood. 2007;110:2276-85 pubmed
  58. van Lohuizen M, Verbeek S, Scheijen B, Wientjens E, van der Gulden H, Berns A. Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging. Cell. 1991;65:737-52 pubmed
  59. Okubo T, Hogan B. Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm. J Biol. 2004;3:11 pubmed
    ..We discuss the relevance of our findings to the poorly understood pathological condition of intestinal metaplasia in humans. ..
  60. Al Matary Y, Botezatu L, Opalka B, Hönes J, Lams R, Thivakaran A, et al. Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner. Haematologica. 2016;101:1216-1227 pubmed
    ..These data may provide new insights and opportunities for novel therapies for acute myeloid leukemia. ..
  61. Igwe E, Kosan C, Khandanpour C, Sharif Askari E, Brüne B, Moroy T. The zinc finger protein Gfi1 is implicated in the regulation of IgG2b production and the expression of Igamma2b germline transcripts. Eur J Immunol. 2008;38:3004-14 pubmed publisher
    b>Gfi1 is a zinc finger transcription factor that is undetectable in B lymphocytes but its expression rises rapidly upon antigenic stimulation or treatment with lipopolysaccharide (LPS)...
  62. Baron M, Gauchat D, La Motte Mohs R, Kettaf N, Abdallah A, Michiels T, et al. TLR Ligand-Induced Type I IFNs Affect Thymopoiesis. J Immunol. 2008;180:7134-46 pubmed
    ..Because TLR ligands are widely used as vaccine adjuvants, their immunomodulatory actions mediated mainly by IFN-alpha suggested by our results should be taken in consideration. ..
  63. Wang Y, Qu X, Yang Y, Han X, Wang L, Qiao H, et al. AMPK promotes osteogenesis and inhibits adipogenesis through AMPK-Gfi1-OPN axis. Cell Signal. 2016;28:1270-82 pubmed publisher
    ..Furthermore, we provided evidence that the transcriptional repressor growth factor independence-1 (Gfi1) was downregulated and disassociated from the OPN promoter in response to AMPK activation, resulting in the ..
  64. Chow K, Schulz D, McWhirter S, Schlissel M. Gfi1 and gfi1b repress rag transcription in plasmacytoid dendritic cells in vitro. PLoS ONE. 2013;8:e75891 pubmed publisher
    Growth factor independence genes (Gfi1 and Gfi1b) repress recombination activating genes (Rag) transcription in developing B lymphocytes...
  65. Shi F, Hu L, Edge A. Generation of hair cells in neonatal mice by ?-catenin overexpression in Lgr5-positive cochlear progenitors. Proc Natl Acad Sci U S A. 2013;110:13851-6 pubmed publisher
    ..Our finding suggests that Wnt/?-catenin can drive Lgr5-positive cells to act as hair cell progenitors, even after their exit from the cell cycle and apparent establishment of cell fate. ..
  66. Yang Z, Ding K, Pan L, Deng M, Gan L. Math5 determines the competence state of retinal ganglion cell progenitors. Dev Biol. 2003;264:240-54 pubmed
  67. Chalmin F, Mignot G, Bruchard M, Chevriaux A, Vegran F, Hichami A, et al. Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression. Immunity. 2012;36:362-73 pubmed publisher
    ..Finally, adoptive transfer of Th17 cells induced by TGF-? and IL-6 promoted tumor growth in a CD39-dependent manner. Thus, ectonucleotidase expression supports the immunosuppressive fate of Th17 cells in cancer. ..
  68. Jaeger B, Donadieu J, Cognet C, Bernat C, Ordoñez Rueda D, Barlogis V, et al. Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis. J Exp Med. 2012;209:565-80 pubmed publisher
    ..These findings reveal novel types of cooperation between cells of the innate immune system and prompt examination of NK cell functional deficiency in patients suffering from neutropenia-associated diseases. ..
  69. Tateno M, Fukunishi Y, Komatsu S, Okazaki Y, Kawai J, Shibata K, et al. Identification of a novel member of the snail/Gfi-1 repressor family, mlt 1, which is methylated and silenced in liver tumors of SV40 T antigen transgenic mice. Cancer Res. 2001;61:1144-53 pubmed
  70. Zhu M, Zhang J, Qu J, Zhang H, Zhou S, Dong S, et al. Up-regulation of growth factor independence 1 in endotoxin tolerant macrophages with low secretion of TNF-alpha and IL-6. Inflamm Res. 2010;59:855-60 pubmed publisher
    ..We hypothesized that growth factor independence 1 (Gfi1) involves in the endotoxin tolerance in macrophages. Endotoxin tolerance was induced in the RAW264...
  71. Oritani K, Kanakura Y, Aoyama K, Yokota T, Copeland N, Gilbert D, et al. Matrix glycoprotein SC1/ECM2 augments B lymphopoiesis. Blood. 1997;90:3404-13 pubmed
    ..Although the C-terminal portion of SC1/ECM2 has sequence homology to osteonectin/SPARC, the unique N-terminal one fifth of the protein was sufficient to augment lymphocyte growth. ..
  72. Binstadt B, Patel P, Alencar H, Nigrovic P, Lee D, Mahmood U, et al. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol. 2006;7:284-92 pubmed
    ..We propose that regionally distinct vascular properties 'interface' with immune effector pathways to foster organ-specific autoimmune damage, perhaps explaining why arthritis accompanies many human infectious and autoimmune disorders. ..
  73. Hönes J, Botezatu L, Helness A, Vadnais C, Vassen L, Robert F, et al. GFI1 as a novel prognostic and therapeutic factor for AML/MDS. Leukemia. 2016;30:1237-45 pubmed publisher
    Genetic and epigenetic aberrations contribute to the initiation and progression of acute myeloid leukemia (AML). GFI1, a zinc-finger transcriptional repressor, exerts its function by recruiting histone deacetylases to target genes...
  74. Burns J, Kelly M, Hoa M, Morell R, Kelley M. Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear. Nat Commun. 2015;6:8557 pubmed publisher
    ..These results provide significant insights into the developmental processes that form unique inner ear cell types. ..
  75. Shi F, Hu L, Jacques B, Mulvaney J, Dabdoub A, Edge A. ?-Catenin is required for hair-cell differentiation in the cochlea. J Neurosci. 2014;34:6470-9 pubmed publisher
    ..Our data demonstrate that ?-catenin plays a role in cell division and differentiation in the cochlear sensory epithelium. ..
  76. Gerbe F, van Es J, Makrini L, Brulin B, Mellitzer G, Robine S, et al. Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium. J Cell Biol. 2011;192:767-80 pubmed publisher
    ..We show that whereas the ATOH1/MATH1 transcription factor is essential for their differentiation, Neurog3, SOX9, GFI1, and SPDEF are dispensable, which distinguishes these cells from enteroendocrine, Paneth, and goblet cells, and ..