Gfap

Summary

Gene Symbol: Gfap
Description: glial fibrillary acidic protein
Alias: AI836096, glial fibrillary acidic protein, intermediate filament protein
Species: mouse
Products:     Gfap

Top Publications

  1. Koo B, Yoon M, Yoon K, Im S, Kim Y, Kim C, et al. An obligatory role of mind bomb-1 in notch signaling of mammalian development. PLoS ONE. 2007;2:e1221 pubmed
    ..Our data provide the first evidence that Mib1 is essential for Jagged as well as Deltalike ligand-mediated Notch signaling in mammalian development, while Neur1, Neur2, and Mib2 are dispensable. ..
  2. Hagemann T, Boelens W, Wawrousek E, Messing A. Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease. Hum Mol Genet. 2009;18:1190-9 pubmed publisher
    ..disease (AxD) is a primary disorder of astrocytes caused by dominant mutations in the gene for glial fibrillary acidic protein (GFAP)...
  3. Islam S, Shinmyo Y, Okafuji T, Su Y, Naser I, Ahmed G, et al. Draxin, a repulsive guidance protein for spinal cord and forebrain commissures. Science. 2009;323:388-93 pubmed publisher
    ..Thus, draxin is a previously unknown chemorepulsive axon guidance molecule required for the development of spinal cord and forebrain commissures. ..
  4. Favaro R, Valotta M, Ferri A, Latorre E, Mariani J, Giachino C, et al. Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. Nat Neurosci. 2009;12:1248-56 pubmed publisher
    ..Their replication was partially rescued by the addition of SHH and was almost fully rescued by conditioned medium from normal cells. Thus, NSCs control their status, at least partly, through Sox2-dependent autocrine mechanisms. ..
  5. Pei Y, Brun S, Markant S, Lento W, Gibson P, Taketo M, et al. WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum. Development. 2012;139:1724-33 pubmed publisher
    ..These studies suggest that the WNT pathway is a potent regulator of cerebellar stem cell growth and differentiation. ..
  6. Potokar M, Stenovec M, Gabrijel M, Li L, Kreft M, Grilc S, et al. Intermediate filaments attenuate stimulation-dependent mobility of endosomes/lysosomes in astrocytes. Glia. 2010;58:1208-19 pubmed publisher
    ..of labeled vesicles in astrocytes, derived from either wild-type (WT) mice or mice deficient in glial fibrillary acidic protein and vimentin (GFAP(-/-)Vim(-/-)), the latter lacking astrocyte IFs...
  7. Lavado A, Lagutin O, Chow L, Baker S, Oliver G. Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis. PLoS Biol. 2010;8: pubmed publisher
    ..Finally, we show that the ectopic expression of Prox1 induces premature differentiation of neural stem cells. ..
  8. Lu Y, Iandiev I, Hollborn M, Körber N, Ulbricht E, Hirrlinger P, et al. Reactive glial cells: increased stiffness correlates with increased intermediate filament expression. FASEB J. 2011;25:624-31 pubmed publisher
    ..and the viscoelastic properties of dissociated single glial cells in wild-type mice, mice lacking glial fibrillary acidic protein and vimentin (GFAP(-/-)Vim(-/-)) in which glial cells are consequently devoid of IFs, and normal Long-..
  9. Kaltezioti V, Kouroupi G, Oikonomaki M, Mantouvalou E, Stergiopoulos A, Charonis A, et al. Prox1 regulates the notch1-mediated inhibition of neurogenesis. PLoS Biol. 2010;8:e1000565 pubmed publisher
    ..Together these data suggest that Prox1 inhibits Notch1 gene expression to control the balance between NPC self-renewal and neuronal differentiation. ..
  10. Kunwar A, Rickmann M, Backofen B, Browski S, Rosenbusch J, Schöning S, et al. Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development. Proc Natl Acad Sci U S A. 2011;108:2575-80 pubmed publisher
    ..Vti1a(-/-) and Vti1b(-/-) single deficient mice were viable without these neuronal defects, indicating that they can substitute for each other in these processes. ..

Detail Information

Publications76

  1. Koo B, Yoon M, Yoon K, Im S, Kim Y, Kim C, et al. An obligatory role of mind bomb-1 in notch signaling of mammalian development. PLoS ONE. 2007;2:e1221 pubmed
    ..Our data provide the first evidence that Mib1 is essential for Jagged as well as Deltalike ligand-mediated Notch signaling in mammalian development, while Neur1, Neur2, and Mib2 are dispensable. ..
  2. Hagemann T, Boelens W, Wawrousek E, Messing A. Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease. Hum Mol Genet. 2009;18:1190-9 pubmed publisher
    ..disease (AxD) is a primary disorder of astrocytes caused by dominant mutations in the gene for glial fibrillary acidic protein (GFAP)...
  3. Islam S, Shinmyo Y, Okafuji T, Su Y, Naser I, Ahmed G, et al. Draxin, a repulsive guidance protein for spinal cord and forebrain commissures. Science. 2009;323:388-93 pubmed publisher
    ..Thus, draxin is a previously unknown chemorepulsive axon guidance molecule required for the development of spinal cord and forebrain commissures. ..
  4. Favaro R, Valotta M, Ferri A, Latorre E, Mariani J, Giachino C, et al. Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. Nat Neurosci. 2009;12:1248-56 pubmed publisher
    ..Their replication was partially rescued by the addition of SHH and was almost fully rescued by conditioned medium from normal cells. Thus, NSCs control their status, at least partly, through Sox2-dependent autocrine mechanisms. ..
  5. Pei Y, Brun S, Markant S, Lento W, Gibson P, Taketo M, et al. WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum. Development. 2012;139:1724-33 pubmed publisher
    ..These studies suggest that the WNT pathway is a potent regulator of cerebellar stem cell growth and differentiation. ..
  6. Potokar M, Stenovec M, Gabrijel M, Li L, Kreft M, Grilc S, et al. Intermediate filaments attenuate stimulation-dependent mobility of endosomes/lysosomes in astrocytes. Glia. 2010;58:1208-19 pubmed publisher
    ..of labeled vesicles in astrocytes, derived from either wild-type (WT) mice or mice deficient in glial fibrillary acidic protein and vimentin (GFAP(-/-)Vim(-/-)), the latter lacking astrocyte IFs...
  7. Lavado A, Lagutin O, Chow L, Baker S, Oliver G. Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis. PLoS Biol. 2010;8: pubmed publisher
    ..Finally, we show that the ectopic expression of Prox1 induces premature differentiation of neural stem cells. ..
  8. Lu Y, Iandiev I, Hollborn M, Körber N, Ulbricht E, Hirrlinger P, et al. Reactive glial cells: increased stiffness correlates with increased intermediate filament expression. FASEB J. 2011;25:624-31 pubmed publisher
    ..and the viscoelastic properties of dissociated single glial cells in wild-type mice, mice lacking glial fibrillary acidic protein and vimentin (GFAP(-/-)Vim(-/-)) in which glial cells are consequently devoid of IFs, and normal Long-..
  9. Kaltezioti V, Kouroupi G, Oikonomaki M, Mantouvalou E, Stergiopoulos A, Charonis A, et al. Prox1 regulates the notch1-mediated inhibition of neurogenesis. PLoS Biol. 2010;8:e1000565 pubmed publisher
    ..Together these data suggest that Prox1 inhibits Notch1 gene expression to control the balance between NPC self-renewal and neuronal differentiation. ..
  10. Kunwar A, Rickmann M, Backofen B, Browski S, Rosenbusch J, Schöning S, et al. Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development. Proc Natl Acad Sci U S A. 2011;108:2575-80 pubmed publisher
    ..Vti1a(-/-) and Vti1b(-/-) single deficient mice were viable without these neuronal defects, indicating that they can substitute for each other in these processes. ..
  11. Li G, Kataoka H, Coughlin S, Pleasure S. Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling. Development. 2009;136:327-35 pubmed publisher
    ..These results demonstrate that the relocation of neural precursors in the dentate gyrus consists of discrete steps regulated by multiple pathways. ..
  12. Cho W, Messing A. Properties of astrocytes cultured from GFAP over-expressing and GFAP mutant mice. Exp Cell Res. 2009;315:1260-72 pubmed publisher
    Alexander disease is a fatal leukoencephalopathy caused by dominantly-acting coding mutations in GFAP. Previous work has also implicated elevations in absolute levels of GFAP as central to the pathogenesis of the disease...
  13. Murga M, Bunting S, Montaña M, Soria R, Mulero F, Canamero M, et al. A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet. 2009;41:891-8 pubmed publisher
  14. Gomi H, Yokoyama T, Itohara S. Role of GFAP in morphological retention and distribution of reactive astrocytes induced by scrapie encephalopathy in mice. Brain Res. 2010;1312:156-67 pubmed publisher
    We have previously demonstrated that mutant mice bearing astrocytes deficient in glial fibrillary acidic protein (GFAP) exhibited typical spongiform degeneration and prion plaque deposition...
  15. Penagarikano O, Abrahams B, Herman E, Winden K, Gdalyahu A, Dong H, et al. Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits. Cell. 2011;147:235-46 pubmed publisher
    ..These data demonstrate a functional role for CNTNAP2 in brain development and provide a new tool for mechanistic and therapeutic research in ASD. ..
  16. Macauley S, Pekny M, Sands M. The role of attenuated astrocyte activation in infantile neuronal ceroid lipofuscinosis. J Neurosci. 2011;31:15575-85 pubmed publisher
    ..The first pathological change observed in the PPT1(-/-) brain is regional areas of glial fibrillary acidic protein (GFAP) upregulation, which predicts future areas of neurodegeneration...
  17. Sheikh B, Dixon M, Thomas T, Voss A. Querkopf is a key marker of self-renewal and multipotency of adult neural stem cells. J Cell Sci. 2012;125:295-309 pubmed publisher
    ..Our results show a strong relationship between Qkf promoter activity and stem cell characteristics, and a progressive decrease in Qkf gene activity as lineage commitment and differentiation proceed in vivo. ..
  18. Lapash Daniels C, Austin E, Rockney D, Jacka E, Hagemann T, Johnson D, et al. Beneficial effects of Nrf2 overexpression in a mouse model of Alexander disease. J Neurosci. 2012;32:10507-15 pubmed publisher
    Alexander disease is a fatal neurodegenerative disease caused by dominant mutations in glial fibrillary acidic protein (GFAP)...
  19. Paliouras G, Hamilton L, Aumont A, Joppé S, Barnabe Heider F, Fernandes K. Mammalian target of rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain. J Neurosci. 2012;32:15012-26 pubmed publisher
    ..activation displays stage specificity, occurring in transiently amplifying (TA) progenitor cells but not in GFAP+ stem cells...
  20. Mamber C, Kamphuis W, Haring N, Peprah N, Middeldorp J, Hol E. GFAP? expression in glia of the developmental and adolescent mouse brain. PLoS ONE. 2012;7:e52659 pubmed publisher
    b>Glial fibrillary acidic protein (GFAP) is the major intermediate filament (IF) protein in astrocytes. In the human brain, GFAP isoforms have unique expression patterns, which indicate that they play distinct functional roles...
  21. Hodge R, Garcia A, Elsen G, Nelson B, Mussar K, Reiner S, et al. Tbr2 expression in Cajal-Retzius cells and intermediate neuronal progenitors is required for morphogenesis of the dentate gyrus. J Neurosci. 2013;33:4165-80 pubmed publisher
    ..These studies indicate that Tbr2 is explicitly required for morphogenesis of the DG and participates in multiple aspects of the intricate developmental process of this structure. ..
  22. Kim J, Kim J, Kim Y, Yang M, Jang H, Kang S, et al. Differential patterns of nestin and glial fibrillary acidic protein expression in mouse hippocampus during postnatal development. J Vet Sci. 2011;12:1-6 pubmed
    Intermediate filaments, including nestin and glial fibrillary acidic protein (GFAP), are important for the brain to accommodate neural activities and changes during development...
  23. Hong S, Song M. STAT3 but not STAT1 is required for astrocyte differentiation. PLoS ONE. 2014;9:e86851 pubmed publisher
    ..5. At E18.5, both phospho-STAT1 and phospho-STAT3 were present in glial fibrillary acidic protein (GFAP)-expressing white matter astrocytes...
  24. Piper M, Harris L, Barry G, Heng Y, Plachez C, Gronostajski R, et al. Nuclear factor one X regulates the development of multiple cellular populations in the postnatal cerebellum. J Comp Neurol. 2011;519:3532-48 pubmed publisher
  25. Niklasson M, Bergström T, Zhang X, Gustafsdottir S, Sjogren M, Edqvist P, et al. Enlarged lateral ventricles and aberrant behavior in mice overexpressing PDGF-B in embryonic neural stem cells. Exp Cell Res. 2010;316:2779-89 pubmed publisher
    ..Adult transgenic males, however, showed behavioral aberrations and locomotor dysfunction. Thus, a tightly regulated expression of PDGF during embryogenesis is required for normal brain development and function in mice. ..
  26. Ekmark Lewén S, Lewén A, Israelsson C, Li G, Farooque M, Olsson Y, et al. Vimentin and GFAP responses in astrocytes after contusion trauma to the murine brain. Restor Neurol Neurosci. 2010;28:311-21 pubmed publisher
    ..The aims for this study were to compare the temporal and spatial expression pattern of vimentin- and glial fibrillary acidic protein (GFAP) in a weight drop model of mild cerebral contusion injury in the rat...
  27. Tian C, Gong Y, Yang Y, Shen W, Wang K, Liu J, et al. Foxg1 has an essential role in postnatal development of the dentate gyrus. J Neurosci. 2012;32:2931-49 pubmed publisher
    ..Last, prenatal deletion of Foxg1 suggests that it is rarely involved in the migration of primordial granule cells. In summary, we report that Foxg1 is critical for DG formation, especially during early postnatal stage. ..
  28. Simon R, Brylka H, Schwegler H, Venkataramanappa S, Andratschke J, Wiegreffe C, et al. A dual function of Bcl11b/Ctip2 in hippocampal neurogenesis. EMBO J. 2012;31:2922-36 pubmed publisher
    ..Together, our data define an important novel regulatory pathway in hippocampal development, by linking transcriptional functions of Bcl11b to Desmoplakin, a molecule known to act on cell adhesion. ..
  29. Wilhelmsson U, Faiz M, de Pablo Y, Sjöqvist M, Andersson D, Widestrand A, et al. Astrocytes negatively regulate neurogenesis through the Jagged1-mediated Notch pathway. Stem Cells. 2012;30:2320-9 pubmed publisher
    ..increased neuronal differentiation of neural progenitor cells when cocultured with astrocytes lacking glial fibrillary acidic protein (GFAP) and vimentin (GFAP(-/-) Vim(-/-) )...
  30. Hagemann T, Paylor R, Messing A. Deficits in adult neurogenesis, contextual fear conditioning, and spatial learning in a Gfap mutant mouse model of Alexander disease. J Neurosci. 2013;33:18698-706 pubmed publisher
    b>Glial fibrillary acidic protein (GFAP) is the major intermediate filament of mature astrocytes in the mammalian CNS...
  31. Yu T, Yaguchi Y, Echevarria D, Martinez S, Basson M. Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum. Development. 2011;138:2957-68 pubmed publisher
    ..Taken together, our data demonstrate that FGF signalling levels have to be tightly controlled throughout cerebellar development in order to maintain the normal development of multiple cell types. ..
  32. Ferron S, Pozo N, Laguna A, Aranda S, Porlan E, Moreno M, et al. Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling. Cell Stem Cell. 2010;7:367-79 pubmed publisher
    ..Finally, Dyrk1a heterozygous NSCs exhibit defects in self-renewal, EGF-dependent cell-fate decisions, and long-term persistence in vivo, suggesting that symmetrical divisions play a role in the maintenance of the SEZ reservoir. ..
  33. Keller A, Gravel M, Kriz J. Live imaging of amyotrophic lateral sclerosis pathogenesis: disease onset is characterized by marked induction of GFAP in Schwann cells. Glia. 2009;57:1130-42 pubmed publisher
    ..of ALS, we generated ALS-(GFAP-luciferase/SOD(G93A)) reporter mouse in which upregulation of glial fibrillary acidic protein (GFAP) can be visualized from live animals throughout the different stages of disease...
  34. Piper M, Moldrich R, Lindwall C, Little E, Barry G, Mason S, et al. Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice. Neural Dev. 2009;4:43 pubmed publisher
  35. Kamphuis W, Mamber C, Moeton M, Kooijman L, Sluijs J, Jansen A, et al. GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer disease. PLoS ONE. 2012;7:e42823 pubmed publisher
    b>Glial fibrillary acidic protein (GFAP) is the main astrocytic intermediate filament (IF). GFAP splice isoforms show differential expression patterns in the human brain...
  36. Way S, McKenna J, Mietzsch U, Reith R, Wu H, Gambello M. Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse. Hum Mol Genet. 2009;18:1252-65 pubmed publisher
  37. Paik J, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun W, et al. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell. 2009;5:540-53 pubmed publisher
    ..Thus, the FoxO family coordinately regulates diverse genes and pathways to govern key aspects of NSC homeostasis in the mammalian brain. ..
  38. Middeldorp J, Boer K, Sluijs J, De Filippis L, Encha Razavi F, Vescovi A, et al. GFAPdelta in radial glia and subventricular zone progenitors in the developing human cortex. Development. 2010;137:313-21 pubmed publisher
    A subpopulation of glial fibrillary acidic protein (GFAP)-expressing cells located along the length of the lateral ventricles in the subventricular zone (SVZ) have been identified as the multipotent neural stem cells of the adult ..
  39. Yu Y, Chen Y, Kim B, Wang H, Zhao C, He X, et al. Olig2 targets chromatin remodelers to enhancers to initiate oligodendrocyte differentiation. Cell. 2013;152:248-61 pubmed publisher
  40. Cho W, Hagemann T, Johnson D, Johnson J, Messing A. Dual transgenic reporter mice as a tool for monitoring expression of glial fibrillary acidic protein. J Neurochem. 2009;110:343-51 pubmed publisher
    b>Glial fibrillary acidic protein (GFAP) is the major intermediate filament protein of astrocytes, and its expression changes dramatically during development and following injury...
  41. Tian H, Sanders E, Reynolds A, van Roy F, van Hengel J. Ocular anterior segment dysgenesis upon ablation of p120 catenin in neural crest cells. Invest Ophthalmol Vis Sci. 2012;53:5139-53 pubmed publisher
    ..Loss of p120ctn and the associated N-cadherin downregulation in NCC leads to ASD without affecting cell migration. p120ctn abnormalities might have a role in the pathophysiology of mammalian eye development. ..
  42. Ferron S, Charalambous M, Radford E, McEwen K, Wildner H, Hind E, et al. Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis. Nature. 2011;475:381-5 pubmed publisher
  43. Imayoshi I, Sakamoto M, Yamaguchi M, Mori K, Kageyama R. Essential roles of Notch signaling in maintenance of neural stem cells in developing and adult brains. J Neurosci. 2010;30:3489-98 pubmed publisher
    ..These results indicated an absolute requirement of Notch signaling for the maintenance of neural stem cells and a proper control of neurogenesis in both embryonic and adult brains. ..
  44. Tanaka K, Takebayashi H, Yamazaki Y, Ono K, Naruse M, Iwasato T, et al. Murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significance. Glia. 2007;55:617-31 pubmed
    Alexander disease is caused by a coding mutation in the glial fibrillary acidic protein (GFAP) gene...
  45. Qi Y, Cai J, Wu Y, Wu R, Lee J, Fu H, et al. Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor. Development. 2001;128:2723-33 pubmed
    ..Consistent with this suggestion, overproduction of Nkx2.2 protein in fibroblast cells can induce gene expression from the proteolipid protein promoter. ..
  46. Kurtz A, Zimmer A, Schnutgen F, Bruning G, Spener F, Muller T. The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development. Development. 1994;120:2637-49 pubmed
  47. Singh R, Nielsen A, Johansen M, Jørgensen A. Genetic polymorphism and sequence evolution of an alternatively spliced exon of the glial fibrillary acidic protein gene, GFAP. Genomics. 2003;82:185-93 pubmed
    Isoform GFAPepsilon of the human cytoskeletal protein GFAP carries, as the result of alternative splicing of exon 7a of GFAP, a novel 42-amino-acid-long C-terminal region with binding capacity for the presenilin proteins...
  48. Bagri A, Marin O, Plump A, Mak J, Pleasure S, Rubenstein J, et al. Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain. Neuron. 2002;33:233-48 pubmed
  49. Andrae J, Bongcam Rudloff E, Hansson I, Lendahl U, Westermark B, Nister M. A 1.8kb GFAP-promoter fragment is active in specific regions of the embryonic CNS. Mech Dev. 2001;107:181-5 pubmed
    The intermediate filament glial fibrillary acidic protein (GFAP) constitutes the major cytoskeletal protein in astrocytes (J. Neuroimmunol. 8 (1985) 203) and is traditionally referred to as a specific marker for astrocytes...
  50. Ohkubo Y, Uchida A, Shin D, Partanen J, Vaccarino F. Fibroblast growth factor receptor 1 is required for the proliferation of hippocampal progenitor cells and for hippocampal growth in mouse. J Neurosci. 2004;24:6057-69 pubmed
    ..quot;floxed" Fgfr1 alleles was directed to cells of the radial glial lineage by using the human glial fibrillary acidic protein promoter...
  51. He F, Ge W, Martinowich K, Becker Catania S, Coskun V, Zhu W, et al. A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis. Nat Neurosci. 2005;8:616-25 pubmed
    ..These observations suggest that autoregulation of the Jak-STAT pathway controls the onset of astrogliogenesis. ..
  52. Owada Y, Abdelwahab S, Kitanaka N, Sakagami H, Takano H, Sugitani Y, et al. Altered emotional behavioral responses in mice lacking brain-type fatty acid-binding protein gene. Eur J Neurosci. 2006;24:175-87 pubmed
    ..These data indicate that B-FABP is crucially involved in the fear memory and anxiety through its binding with FAs and/or its own direct effects on pertinent metabolism/signaling of FAs. ..
  53. SMITH K, Ohkubo Y, Maragnoli M, Rasin M, Schwartz M, Sestan N, et al. Midline radial glia translocation and corpus callosum formation require FGF signaling. Nat Neurosci. 2006;9:787-97 pubmed
    ..Hence, FGFs have an important role in the transition from radial glia to astrocytes by stimulating somal translocation of radial glial cells. ..
  54. Ono K, Takebayashi H, Ikeda K, Furusho M, Nishizawa T, Watanabe K, et al. Regional- and temporal-dependent changes in the differentiation of Olig2 progenitors in the forebrain, and the impact on astrocyte development in the dorsal pallium. Dev Biol. 2008;320:456-68 pubmed publisher
    ..These observations indicate that embryonic Olig2+ progenitor cells change their differentiative properties during development, and also that Olig2 plays a role in astrocyte development in a region-specific manner. ..
  55. Natarajan D, Grigoriou M, Marcos Gutierrez C, Atkins C, Pachnis V. Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture. Development. 1999;126:157-68 pubmed
    ..Our data show the NC-derived RET+ population of fetal gut in mammalian embryos consists of multipotential progenitors capable of colonising efficiently both wild-type and RET-deficient aganglionic bowel in organ culture. ..
  56. Graus Porta D, Blaess S, Senften M, Littlewood Evans A, Damsky C, Huang Z, et al. Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron. 2001;31:367-79 pubmed
    ..The phenotype of the beta1-deficient mice resembles pathological changes observed in human cortical dysplasias, suggesting that defective integrin-mediated signal transduction contributes to the development of some of these diseases. ..
  57. Pacey L, Doering L. Developmental expression of FMRP in the astrocyte lineage: implications for fragile X syndrome. Glia. 2007;55:1601-9 pubmed
    ..When the neurospheres were differentiated in vitro, approximately 50% of the FMRP positive cells also expressed GFAP. Immunocytochemical studies of the embryonic and postnatal mouse brain revealed coexpression of FMRP and GFAP in ..
  58. Galceran J, Miyashita Lin E, Devaney E, Rubenstein J, Grosschedl R. Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development. 2000;127:469-82 pubmed
    ..Thus, LEF1 regulates the generation of dentate gyrus granule cells, and together with other LEF1/TCF proteins, the development of the hippocampus. ..
  59. Feng L, Hatten M, Heintz N. Brain lipid-binding protein (BLBP): a novel signaling system in the developing mammalian CNS. Neuron. 1994;12:895-908 pubmed
    ..Based on these results, we propose that BLBP is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers. ..
  60. Kioussi C, Gross M, Gruss P. Pax3: a paired domain gene as a regulator in PNS myelination. Neuron. 1995;15:553-62 pubmed
    ..Treating cultures with forskolin, an adenylate cyclase agonist, repressed Pax3 RNA, GFAP, NGFR, N-CAM, and L1 and elevated MBP...
  61. Shu T, Li Y, Keller A, Richards L. The glial sling is a migratory population of developing neurons. Development. 2003;130:2929-37 pubmed
    ..These data indicate that the sling may be a source of, or migratory pathway for, developing neurons in the rostral forebrain, suggesting additional functions for the sling independent of callosal axon guidance. ..
  62. Taranova O, Magness S, Fagan B, Wu Y, Surzenko N, Hutton S, et al. SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes Dev. 2006;20:1187-202 pubmed
  63. Liu X, Bolteus A, Balkin D, Henschel O, Bordey A. GFAP-expressing cells in the postnatal subventricular zone display a unique glial phenotype intermediate between radial glia and astrocytes. Glia. 2006;54:394-410 pubmed
    ..in the adult subventricular zone (SVZ) derive from radial glia and express the astroglial marker glial fibrillary acidic protein (GFAP). Thus, they have been termed astrocytes...
  64. Triolo D, Dina G, Lorenzetti I, Malaguti M, Morana P, Del Carro U, et al. Loss of glial fibrillary acidic protein (GFAP) impairs Schwann cell proliferation and delays nerve regeneration after damage. J Cell Sci. 2006;119:3981-93 pubmed
    ..We investigated whether peripheral nerve regeneration is perturbed in mice that lack glial fibrillary acidic protein (GFAP), a Schwann-cell-specific cytoskeleton constituent upregulated after damage...
  65. Morshead C, Garcia A, Sofroniew M, van der Kooy D. The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells. Eur J Neurosci. 2003;18:76-84 pubmed
    ..Using a transgenic mouse expressing herpes-simplex virus thymidine kinase from the glial fibrillary acidic protein (GFAP) promotor, we have selectively killed dividing GFAP-positive cells in the presence of ..
  66. Reuss B, Dono R, Unsicker K. Functions of fibroblast growth factor (FGF)-2 and FGF-5 in astroglial differentiation and blood-brain barrier permeability: evidence from mouse mutants. J Neurosci. 2003;23:6404-12 pubmed
    ..Using FGF-2 and FGF-5 single- and double mutant mice we show now a region-specific reduction of glial fibrillary acidic protein (GFAP), but not of S100 in gray matter astrocytes...
  67. Mendes S, Henkemeyer M, Liebl D. Multiple Eph receptors and B-class ephrins regulate midline crossing of corpus callosum fibers in the developing mouse forebrain. J Neurosci. 2006;26:882-92 pubmed
    ..Our results support a significant role for ephrins and Eph receptors in CC development and may provide insight to possible mechanisms involved in axon midline crossing and human disorder. ..
  68. Keeble T, Halford M, Seaman C, Kee N, Macheda M, Anderson R, et al. The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum. J Neurosci. 2006;26:5840-8 pubmed
    ..Our analysis of Ryk function further advances our understanding of the molecular mechanisms underlying the formation of this important commissure. ..
  69. Koblar S, Turnley A, Classon B, Reid K, Ware C, Cheema S, et al. Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptor. Proc Natl Acad Sci U S A. 1998;95:3178-81 pubmed
    ..the low-affinity leukemia inhibitory factor receptor (LIFR-/-) fail to generate astrocytes expressing glial fibrillary acidic protein (GFAP) when cultured in vitro...
  70. Yuasa S. Bergmann glial development in the mouse cerebellum as revealed by tenascin expression. Anat Embryol (Berl). 1996;194:223-34 pubmed
    ..as a marker of astroglial development from an early stage, especially prior to the expression of the glial fibrillary acidic protein (GFAP) that can be detected in the postnatal cerebellum...
  71. Tang G, Xu Z, Goldman J. Synergistic effects of the SAPK/JNK and the proteasome pathway on glial fibrillary acidic protein (GFAP) accumulation in Alexander disease. J Biol Chem. 2006;281:38634-43 pubmed
    Protein aggregates in astrocytes that contain glial fibrillary acidic protein (GFAP), small heat shock proteins, and ubiquitinated proteins are termed Rosenthal fibers and characterize Alexander disease, a leukodystrophy caused by ..
  72. Mignot C, Delarasse C, Escaich S, Della Gaspera B, NOE E, Colucci Guyon E, et al. Dynamics of mutated GFAP aggregates revealed by real-time imaging of an astrocyte model of Alexander disease. Exp Cell Res. 2007;313:2766-79 pubmed
    ..in astrocytes and myelin abnormalities and caused by dominant mutations in the gene encoding glial fibrillary acidic protein (GFAP), the main intermediate filament protein in astrocytes...
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    ..astrocytes and astrocytoma cells contain synemin and three other intermediate filament (IF) proteins: glial fibrillary acidic protein (GFAP), vimentin and nestin...
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    ..Resulting differences in protein amounts might be a main reason for the weaker impact of Sox8 on oligodendrocyte development and for unidirectional compensation of the Sox8 loss by Sox10. ..
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    Mutations in the gene for the astrocyte specific intermediate filament, glial fibrillary acidic protein (GFAP), cause the rare leukodystrophy Alexander disease (AxD)...
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    b>Glial fibrillary acidic protein (GFAP) is the principle intermediate filament (IF) protein in astrocytes...