germ cell less
Gene Symbol: germ cell less
Description: germ cell-less, spermatogenesis associated 1
Alias: 2810049L19Rik, Btbd13, DIP, Gcl, Gcl-1, glc-1, mglc-1, germ cell-less protein-like 1, DP-interacting protein, germ cell-less homolog 1
Kimura T, Yomogida K, Iwai N, Kato Y, Nakano T. Molecular cloning and genomic organization of mouse homologue of Drosophila germ cell-less and its expression in germ lineage cells. Biochem Biophys Res Commun. 1999;262:223-30 pubmed
..Here we describe cloning, genomic structure and expression of mouse homologue of germ cell-less (gcl) gene which is required for PGCs formation in Drosophila...
Kimura T, Ito C, Watanabe S, Takahashi T, Ikawa M, Yomogida K, et al
. Mouse germ cell-less as an essential component for nuclear integrity. Mol Cell Biol. 2003;23:1304-15 pubmed
Maekawa M, Ito C, Toyama Y, Suzuki Toyota F, Kimura T, Nakano T, et al
. Stage-specific expression of mouse germ cell-less-1 (mGCL-1), and multiple deformations during mgcl-1 deficient spermatogenesis leading to reduced fertility. Arch Histol Cytol. 2004;67:335-47 pubmed
..These observations provide important insights into the mechanisms regulating the nuclear architecture and causes of human infertility. ..
Nili E, Cojocaru G, Kalma Y, Ginsberg D, Copeland N, Gilbert D, et al
. Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less). J Cell Sci. 2001;114:3297-307 pubmed
..protein, mGCL, which contains a BTB/POZ domain and is the mouse homologue of the Drosophila germ-cell-less (GCL) protein...
Liebe B, Petukhova G, Barchi M, Bellani M, Braselmann H, Nakano T, et al
. Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages. Exp Cell Res. 2006;312:3768-81 pubmed
..Altogether, it appears that several pathways influence telomere dynamics in mammalian meiosis. ..
de la Luna S, Allen K, Mason S, La Thangue N. Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor. EMBO J. 1999;18:212-28 pubmed
..We report the identification and characterization of DIP, a novel mammalian protein that can interact with the DP component of E2F...
Leatherman J, Kaestner K, Jongens T. Identification of a mouse germ cell-less homologue with conserved activity in Drosophila. Mech Dev. 2000;92:145-53 pubmed
Drosophila Germ cell-less (Gcl) has previously been shown to be important in early events during the formation of pole cells, which are the germ cell precursors in the fly...
Masuhara M, Nagao K, Nishikawa M, Kimura T, Nakano T. Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less. Biochem Biophys Res Commun. 2003;308:927-32 pubmed
A mouse homologue of Drosophila germ cell less, mouse germ cell less-1 (mgcl-1), encodes a nuclear envelope component essential for nuclear integrity...