Gene Symbol: Gem
Description: GTP binding protein (gene overexpressed in skeletal muscle)
Alias: AV020497, GTP-binding protein GEM, GTP-binding mitogen-induced T-cell protein, RAS-like protein KIR
Species: mouse
Products:     Gem

Top Publications

  1. Romberg C, Beqollari D, Meza U, Bannister R. RGK protein-mediated impairment of slow depolarization- dependent Ca2+ entry into developing myotubes. Channels (Austin). 2014;8:243-8 pubmed
    ..Members of the RGK (Rad, Rem, Rem2, Gem/Kir) family of monomeric GTP-binding proteins are potent inhibitors of the former two functions of Ca(V)1.1...
  2. Santoro T, Maguire J, McBride O, Avraham K, Copeland N, Jenkins N, et al. Chromosomal organization and transcriptional regulation of human GEM and localization of the human and mouse GEM loci encoding an inducible Ras-like protein. Genomics. 1995;30:558-64 pubmed
    The mitogen-induced gene, GEM, encodes a GTP-binding protein that belongs to a new family within the Ras superfamily. The regulated expression pattern of Gem suggests a role for this protein in cellular responses to growth stimulation...
  3. Mahalakshmi R, Nagashima K, Ng M, Inagaki N, Hunziker W, Beguin P. Nuclear transport of Kir/Gem requires specific signals and importin alpha5 and is regulated by calmodulin and predicted serine phosphorylations. Traffic. 2007;8:1150-63 pubmed
    Kir/Gem, together with Rad, Rem and Rem2, is a member of the RGK small GTP-binding protein family. These multifunctional proteins regulate voltage-gated calcium channel (VGCC) activity and cell-shape remodeling...
  4. Beguin P, Mahalakshmi R, Nagashima K, Cher D, Takahashi A, Yamada Y, et al. 14-3-3 and calmodulin control subcellular distribution of Kir/Gem and its regulation of cell shape and calcium channel activity. J Cell Sci. 2005;118:1923-34 pubmed
    Individual members of the RGK family of Ras-related GTPases, which comprise Rad, Gem/Kir, Rem and Rem2, have been implicated in important functions such as the regulation of voltage-gated calcium channel activity and remodeling of cell ..
  5. Popova N, Morris R. Genetic regulation of mouse stem cells: identification of two keratinocyte stem cell regulatory loci. Curr Top Microbiol Immunol. 2004;280:111-37 pubmed
  6. Feng J, Lawson M, Melamed P. A proteomic comparison of immature and mature mouse gonadotrophs reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing. Biol Reprod. 2008;79:546-61 pubmed publisher
    ..This study has revealed a number of novel factors that alter gonadotropin expression and gonadotroph function, and likely mediate or moderate effects of the regulatory hormones. ..
  7. Beguin P, Ng Y, Krause C, Mahalakshmi R, Ng M, Hunziker W. RGK small GTP-binding proteins interact with the nucleotide kinase domain of Ca2+-channel beta-subunits via an uncommon effector binding domain. J Biol Chem. 2007;282:11509-20 pubmed
    RGK proteins (Kir/Gem, Rad, Rem, and Rem2) form a small subfamily of the Ras superfamily...
  8. Popova N, Teti K, Wu K, Morris R. Identification of two keratinocyte stem cell regulatory loci implicated in skin carcinogenesis. Carcinogenesis. 2003;24:417-25 pubmed
  9. Downes G, Gilbert D, Copeland N, Gautam N, Jenkins N. Chromosomal mapping of five mouse G protein gamma subunits. Genomics. 1999;57:173-6 pubmed
    ..Combined with previous mapping studies, these data indicate that, with the possible exception of gamma1 and gamma11, the G protein gamma subunit genes are well dispersed within the mouse and human genomes. ..

More Information


  1. Fischer R, Wei Y, Anagli J, Berchtold M. Calmodulin binds to and inhibits GTP binding of the ras-like GTPase Kir/Gem. J Biol Chem. 1996;271:25067-70 pubmed
    Recently, a new subfamily of Ras-related GTP-binding proteins consisting of Rad (Ras associated with diabetes), Gem (immediate early gene expressed in mitogen-stimulated T-cells), and Kir (tyrosine kinase-inducible Ras-like) was ..
  2. Maguire J, Santoro T, Jensen P, Siebenlist U, Yewdell J, Kelly K. Gem: an induced, immediate early protein belonging to the Ras family. Science. 1994;265:241-4 pubmed
    A gene encoding a 35-kilodalton guanosine triphosphate (GTP)-binding protein, Gem, was cloned from mitogen-induced human peripheral blood T cells...
  3. Piddini E, Schmid J, de Martin R, Dotti C. The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9. EMBO J. 2001;20:4076-87 pubmed
    b>Gem belongs to the Rad/Gem/Kir (RGK) subfamily of Ras-related GTPases, which also comprises Rem, Rem2 and Ges...
  4. Cohen L, Mohr R, Chen Y, Huang M, Kato R, Dorin D, et al. Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases. Proc Natl Acad Sci U S A. 1994;91:12448-52 pubmed
    ..BCR/ABL and v-Abl induce transcription of the kir gene via specific signaling pathway(s), but kir overexpression alone is not sufficient to mediate transformation. ..
  5. Ward Y, Spinelli B, Quon M, Chen H, Ikeda S, Kelly K. Phosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activity. Mol Cell Biol. 2004;24:651-61 pubmed
    b>Gem is a small GTP-binding protein that has a ras-like core and extended chains at each terminus...
  6. Sasaki T, Shibasaki T, Beguin P, Nagashima K, Miyazaki M, Seino S. Direct inhibition of the interaction between alpha-interaction domain and beta-interaction domain of voltage-dependent Ca2+ channels by Gem. J Biol Chem. 2005;280:9308-12 pubmed
    The Ras-related small G-protein Gem regulates voltage-dependent Ca2+ channels (VDCCs) through interaction with the beta-subunit of the VDCC. This action of Gem is mediated by regulated alpha1-subunit expression at the plasma membrane...
  7. Beguin P, Nagashima K, Gonoi T, Shibasaki T, Takahashi K, Kashima Y, et al. Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem. Nature. 2001;411:701-6 pubmed
    ..We report here that the GTP-bound form of kir/Gem, identified originally as a Ras-related small G-protein that binds CaM, inhibits high-voltage-activated Ca2+ ..
  8. Huang K, Johnson K, Petcherski A, Vandergon T, Mosser E, Copeland N, et al. A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis. Gene. 2000;252:137-45 pubmed
    ..CeWWP1 must therefore have unique and nonredundant functions critical for embryogenesis. ..
  9. Gunton J, Sisavanh M, Stokes R, Satin J, Satin L, Zhang M, et al. Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling. PLoS ONE. 2012;7:e39462 pubmed publisher
    ..Regulation of calcium handling in beta-cells remains incompletely understood. Gem, a member of the RGK (Rad/Gem/Kir) family regulates calcium channel handling in other cell types, and Gem over-..
  10. Hoekstra E, von Oerthel L, van der Linden A, Schellevis R, Scheppink G, Holstege F, et al. Lmx1a is an activator of Rgs4 and Grb10 and is responsible for the correct specification of rostral and medial mdDA neurons. Eur J Neurosci. 2013;37:23-32 pubmed publisher
    ..Taken together, microarray analysis of an LMX1A-overexpression cell system resulted in the identification of novel direct or indirect downstream targets of Lmx1a in mdDA neurons: Grb10, Rgs4 and Vmat2. ..