GATA4

Summary

Gene Symbol: GATA4
Description: GATA binding protein 4
Alias: Gata-4, transcription factor GATA-4, GATA-binding factor 4
Species: mouse
Products:     GATA4

Top Publications

  1. Svensson E, Huggins G, Lin H, Clendenin C, Jiang F, Tufts R, et al. A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2. Nat Genet. 2000;25:353-6 pubmed
    ..Most cases of TA are sporadic, but familial occurrences with disease in multiple siblings have been reported. Gata4 is a zinc-finger transcription factor with a role in early cardiac development...
  2. Kuo C, Morrisey E, Anandappa R, Sigrist K, Lu M, Parmacek M, et al. GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 1997;11:1048-60 pubmed
    Previous studies have suggested that the GATA4 transcription factor plays an important role in regulating mammalian cardiac development. In the studies described in this report we have used gene targeting to produce GATA4-deficient mice...
  3. Tremblay J, Viger R. Transcription factor GATA-4 is activated by phosphorylation of serine 261 via the cAMP/protein kinase a signaling pathway in gonadal cells. J Biol Chem. 2003;278:22128-35 pubmed
  4. Spencer Dene B, Sala F, Bellusci S, Gschmeissner S, Stamp G, Dickson C. Stomach development is dependent on fibroblast growth factor 10/fibroblast growth factor receptor 2b-mediated signaling. Gastroenterology. 2006;130:1233-44 pubmed
    ..and chief cell lineages was rudimentary, with no expression of several early cytodifferentiation markers including GATA4, GATA6, and H+/K+-adenosine triphosphatase and abnormal expression of members of the hedgehog family of signaling ..
  5. Philips A, Kwok J, Chong B. Analysis of the signals and mechanisms mediating nuclear trafficking of GATA-4. Loss of DNA binding is associated with localization in intranuclear speckles. J Biol Chem. 2007;282:24915-27 pubmed
    ..The current study provides detailed information on the nuclear shuttling pathways of GATA-4 that represents an additional mechanism of gene regulation. ..
  6. Battle M, Bondow B, Iverson M, Adams S, Jandacek R, Tso P, et al. GATA4 is essential for jejunal function in mice. Gastroenterology. 2008;135:1676-1686.e1 pubmed publisher
    Although the zinc-finger transcription factor GATA4 has been implicated in regulating jejunal gene expression, the contribution of GATA4 in controlling jejunal physiology has not been addressed...
  7. Rojas A, Schachterle W, Xu S, Black B. An endoderm-specific transcriptional enhancer from the mouse Gata4 gene requires GATA and homeodomain protein-binding sites for function in vivo. Dev Dyn. 2009;238:2588-98 pubmed publisher
    ..function in the specification and differentiation of the endoderm, including the zinc finger transcription factor GATA4. Despite its essential role in endoderm development, the transcriptional control of the Gata4 gene in the ..
  8. Yamak A, Latinkic B, Dali R, Temsah R, Nemer M. Cyclin D2 is a GATA4 cofactor in cardiogenesis. Proc Natl Acad Sci U S A. 2014;111:1415-20 pubmed publisher
    ..Here, we show that a G1 cyclin, cyclin D2 (CycD2), enhances the activity of transcription factor GATA4, a key regulator of cardiomyocyte growth and differentiation...
  9. Anttonen M, Ketola I, Parviainen H, Pusa A, Heikinheimo M. FOG-2 and GATA-4 Are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression. Biol Reprod. 2003;68:1333-40 pubmed
    ..In postnatal ovary, granulosa cells of growing follicles express FOG-2, partially overlapping with the expression of MIS. These data suggest an important role for FOG-2 and the GATA transcription factors in the developing ovary. ..
  10. Rojas A, De Val S, Heidt A, Xu S, Bristow J, Black B. Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element. Development. 2005;132:3405-17 pubmed
    ..b>GATA4 is an early regulator of gene expression during the development of endoderm and mesoderm, and genetic studies in ..

Detail Information

Publications102 found, 100 shown here

  1. Svensson E, Huggins G, Lin H, Clendenin C, Jiang F, Tufts R, et al. A syndrome of tricuspid atresia in mice with a targeted mutation of the gene encoding Fog-2. Nat Genet. 2000;25:353-6 pubmed
    ..Most cases of TA are sporadic, but familial occurrences with disease in multiple siblings have been reported. Gata4 is a zinc-finger transcription factor with a role in early cardiac development...
  2. Kuo C, Morrisey E, Anandappa R, Sigrist K, Lu M, Parmacek M, et al. GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 1997;11:1048-60 pubmed
    Previous studies have suggested that the GATA4 transcription factor plays an important role in regulating mammalian cardiac development. In the studies described in this report we have used gene targeting to produce GATA4-deficient mice...
  3. Tremblay J, Viger R. Transcription factor GATA-4 is activated by phosphorylation of serine 261 via the cAMP/protein kinase a signaling pathway in gonadal cells. J Biol Chem. 2003;278:22128-35 pubmed
  4. Spencer Dene B, Sala F, Bellusci S, Gschmeissner S, Stamp G, Dickson C. Stomach development is dependent on fibroblast growth factor 10/fibroblast growth factor receptor 2b-mediated signaling. Gastroenterology. 2006;130:1233-44 pubmed
    ..and chief cell lineages was rudimentary, with no expression of several early cytodifferentiation markers including GATA4, GATA6, and H+/K+-adenosine triphosphatase and abnormal expression of members of the hedgehog family of signaling ..
  5. Philips A, Kwok J, Chong B. Analysis of the signals and mechanisms mediating nuclear trafficking of GATA-4. Loss of DNA binding is associated with localization in intranuclear speckles. J Biol Chem. 2007;282:24915-27 pubmed
    ..The current study provides detailed information on the nuclear shuttling pathways of GATA-4 that represents an additional mechanism of gene regulation. ..
  6. Battle M, Bondow B, Iverson M, Adams S, Jandacek R, Tso P, et al. GATA4 is essential for jejunal function in mice. Gastroenterology. 2008;135:1676-1686.e1 pubmed publisher
    Although the zinc-finger transcription factor GATA4 has been implicated in regulating jejunal gene expression, the contribution of GATA4 in controlling jejunal physiology has not been addressed...
  7. Rojas A, Schachterle W, Xu S, Black B. An endoderm-specific transcriptional enhancer from the mouse Gata4 gene requires GATA and homeodomain protein-binding sites for function in vivo. Dev Dyn. 2009;238:2588-98 pubmed publisher
    ..function in the specification and differentiation of the endoderm, including the zinc finger transcription factor GATA4. Despite its essential role in endoderm development, the transcriptional control of the Gata4 gene in the ..
  8. Yamak A, Latinkic B, Dali R, Temsah R, Nemer M. Cyclin D2 is a GATA4 cofactor in cardiogenesis. Proc Natl Acad Sci U S A. 2014;111:1415-20 pubmed publisher
    ..Here, we show that a G1 cyclin, cyclin D2 (CycD2), enhances the activity of transcription factor GATA4, a key regulator of cardiomyocyte growth and differentiation...
  9. Anttonen M, Ketola I, Parviainen H, Pusa A, Heikinheimo M. FOG-2 and GATA-4 Are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression. Biol Reprod. 2003;68:1333-40 pubmed
    ..In postnatal ovary, granulosa cells of growing follicles express FOG-2, partially overlapping with the expression of MIS. These data suggest an important role for FOG-2 and the GATA transcription factors in the developing ovary. ..
  10. Rojas A, De Val S, Heidt A, Xu S, Bristow J, Black B. Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element. Development. 2005;132:3405-17 pubmed
    ..b>GATA4 is an early regulator of gene expression during the development of endoderm and mesoderm, and genetic studies in ..
  11. Brewer A, Alexandrovich A, Mjaatvedt C, Shah A, Patient R, Pizzey J. GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis. Stem Cells Dev. 2005;14:425-39 pubmed
  12. Karamboulas C, Dakubo G, Liu J, De Repentigny Y, Yutzey K, Wallace V, et al. Disruption of MEF2 activity in cardiomyoblasts inhibits cardiomyogenesis. J Cell Sci. 2006;119:4315-21 pubmed
    ..an Nkx2-5 enhancer in the P19 system resulted in the loss of both cardiomyocyte development and the expression of GATA4, BMP4, Nkx2-5 and MEF2C...
  13. He A, Shen X, Ma Q, Cao J, von Gise A, Zhou P, et al. PRC2 directly methylates GATA4 and represses its transcriptional activity. Genes Dev. 2012;26:37-42 pubmed publisher
    ..Both in vitro and in fetal hearts, EZH2 interacted with cardiac transcription factor GATA4 and directly methylated it at Lys 299...
  14. Kang M, Piliszek A, Artus J, Hadjantonakis A. FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse. Development. 2013;140:267-79 pubmed publisher
    ..Instead, depending on concentration, we noted no effect or conversion of all ICM cells to GATA6-positive PrE. We propose that heterogeneities in the availability of FGF produce the salt-and-pepper distribution of lineage-biased cells...
  15. Cirillo L, Lin F, Cuesta I, Friedman D, Jarnik M, Zaret K. Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4. Mol Cell. 2002;9:279-89 pubmed
    ..Thus, factors that potentiate transcription in development are inherently capable of initiating chromatin opening events. ..
  16. Kanai Azuma M, Kanai Y, Gad J, Tajima Y, Taya C, Kurohmaru M, et al. Depletion of definitive gut endoderm in Sox17-null mutant mice. Development. 2002;129:2367-79 pubmed
    ..Our findings indicate an important role of Sox17 in endoderm development in the mouse, highlighting the idea that the molecular mechanism for endoderm formation is likely to be conserved among vertebrates. ..
  17. Tevosian S, Albrecht K, Crispino J, Fujiwara Y, Eicher E, Orkin S. Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Development. 2002;129:4627-34 pubmed
    ..We demonstrate that the transcription factor GATA4 and its co-factor FOG2 are required for gonadal differentiation...
  18. Niu Z, Yu W, Zhang S, Barron M, Belaguli N, Schneider M, et al. Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem. 2005;280:32531-8 pubmed
    ..myocytes in aggregated SRF null embryonic stem cells, whereas the appearance of transcription factors Nkx2-5 and GATA4 were unaffected...
  19. Prall O, Menon M, Solloway M, Watanabe Y, Zaffran S, Bajolle F, et al. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell. 2007;128:947-59 pubmed
  20. Snyder M, Huang X, Zhang J. Stat3 directly controls the expression of Tbx5, Nkx2.5, and GATA4 and is essential for cardiomyocyte differentiation of P19CL6 cells. J Biol Chem. 2010;285:23639-46 pubmed publisher
    ..5, and GATA4. We further demonstrate that Tbx5, Nkx2...
  21. Ritz Laser B, Mamin A, Brun T, Avril I, Schwitzgebel V, Philippe J. The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression. Mol Endocrinol. 2005;19:759-70 pubmed
  22. Decker K, Goldman D, Grasch C, Sussel L. Gata6 is an important regulator of mouse pancreas development. Dev Biol. 2006;298:415-29 pubmed
    b>Gata4, Gata5, and Gata6 represent a subfamily of zinc-finger transcriptional regulators that are important in the development and differentiation of numerous tissues, including many endodermally-derived organs...
  23. RIVERA FELICIANO J, Lee K, Kong S, Rajagopal S, Ma Q, Springer Z, et al. Development of heart valves requires Gata4 expression in endothelial-derived cells. Development. 2006;133:3607-18 pubmed
    ..b>Gata4, which encodes a zinc finger transcription factor, is expressed in the endothelium and mesenchyme of the AV valves...
  24. Cai K, Capo Chichi C, Rula M, Yang D, Xu X. Dynamic GATA6 expression in primitive endoderm formation and maturation in early mouse embryogenesis. Dev Dyn. 2008;237:2820-9 pubmed publisher
    ..b>GATA4 and GATA6 are the key transcription factors in the formation of extraembryonic endoderms, but their specific ..
  25. Maitra M, Schluterman M, Nichols H, Richardson J, Lo C, Srivastava D, et al. Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Dev Biol. 2009;326:368-77 pubmed publisher
    ..Previously, we described a point mutation in GATA4 that segregated with cardiac defects in a family with autosomal dominant disease...
  26. Artus J, Piliszek A, Hadjantonakis A. The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev Biol. 2011;350:393-404 pubmed publisher
    ..This dynamic distribution of SOX17 resembled the localization of GATA6 and GATA4, two other PrE lineage-specific transcription factors...
  27. Viger R, Mertineit C, Trasler J, Nemer M. Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Müllerian inhibiting substance promoter. Development. 1998;125:2665-75 pubmed
    ..Thus, transcription factor GATA-4 may be a new factor in the cascade of regulators that control gonadal development and sex differentiation in mammals. ..
  28. Zeisberg E, Ma Q, Juraszek A, Moses K, Schwartz R, Izumo S, et al. Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest. 2005;115:1522-31 pubmed
    ..One such regulatory gene is Gata4, a zinc finger transcription factor...
  29. Pilon N, Raiwet D, Viger R, Silversides D. Novel pre- and post-gastrulation expression of Gata4 within cells of the inner cell mass and migratory neural crest cells. Dev Dyn. 2008;237:1133-43 pubmed publisher
    b>GATA4 is a transcription factor known to be important for the development of many organs such as the heart, intestine, and gonads. However, information regarding the control of its expression is only now beginning to emerge...
  30. Mwinyi J, Nekvindova J, Cavaco I, Hofmann Y, Pedersen R, Landman E, et al. New insights into the regulation of CYP2C9 gene expression: the role of the transcription factor GATA-4. Drug Metab Dispos. 2010;38:415-21 pubmed publisher
    ..Taken together, these data strongly suggest an involvement of liver-specific transcription factor GATA-4 in the transcriptional regulation of CYP2C9. ..
  31. van Berlo J, Elrod J, Aronow B, Pu W, Molkentin J. Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2011;108:12331-6 pubmed publisher
    ..b>GATA4 is a critical transcription factor in the heart that is known to induce/regulate the hypertrophic program, in part,..
  32. Ounzain S, Kobayashi S, Peterson R, He A, Motterle A, Samani N, et al. Cardiac expression of ms1/STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4. Mol Cell Biol. 2012;32:1830-43 pubmed publisher
    ..Two of these ECRs, ? and DINA, displayed distinct regulatory sensitivity to the core cardiac transcription factor GATA4. Overall, our results demonstrate that within embryonic, neonatal, and adult hearts, GATA4 represses ms1/STARS ..
  33. Aksoy I, Jauch R, Chen J, Dyla M, Divakar U, Bogu G, et al. Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm. EMBO J. 2013;32:938-53 pubmed publisher
    ..This work provides insights in understanding cell fate transcriptional regulation by highlighting the direct link between the DNA sequence of an enhancer and a developmental outcome...
  34. Svensson E, Tufts R, Polk C, Leiden J. Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes. Proc Natl Acad Sci U S A. 1999;96:956-61 pubmed
  35. Mazaud Guittot S, Tétu A, Legault E, Pilon N, Silversides D, Viger R. The proximal Gata4 promoter directs reporter gene expression to sertoli cells during mouse gonadal development. Biol Reprod. 2007;76:85-95 pubmed
    The GATA4 transcription factor is an important developmental determinant for many organs, such as the heart, gut, and testis...
  36. Miyamoto Y, Taniguchi H, Hamel F, Silversides D, Viger R. A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation. BMC Mol Biol. 2008;9:44 pubmed publisher
    ..Sry expression has been shown to be markedly reduced in transgenic mice harboring a mutant GATA4 protein (a member of the GATA family of transcription factors) disrupted in its ability to interact with its ..
  37. Plusa B, Piliszek A, Frankenberg S, Artus J, Hadjantonakis A. Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst. Development. 2008;135:3081-91 pubmed publisher
    ..Subsequently, a gradual progression towards a mutually exclusive expression of PrE- and EPI-specific markers occurs. Finally, cell sorting is achieved by a variety of cell behaviours and by selective apoptosis. ..
  38. Yang D, Smith E, Cai K, Xu X. C-Fos elimination compensates for disabled-2 requirement in mouse extraembryonic endoderm development. Dev Dyn. 2009;238:514-23 pubmed publisher
  39. Norden J, Grieskamp T, Lausch E, van Wijk B, van den Hoff M, Englert C, et al. Wt1 and retinoic acid signaling in the subcoelomic mesenchyme control the development of the pleuropericardial membranes and the sinus horns. Circ Res. 2010;106:1212-20 pubmed publisher
    ..Thus, our results provide novel insight into the genetic and cellular pathways regulating the posterior extension of the mammalian heart and the formation of its coelomic lining. ..
  40. Sirard C, de la Pompa J, Elia A, Itie A, Mirtsos C, Cheung A, et al. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev. 1998;12:107-19 pubmed
    ..Rescued embryos show severe anterior truncations, indicating a second important role for Smad4 in anterior patterning during embryogenesis. ..
  41. Bosse T, Piaseckyj C, Burghard E, Fialkovich J, Rajagopal S, Pu W, et al. Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine. Mol Cell Biol. 2006;26:9060-70 pubmed
    b>Gata4, a member of the zinc finger family of GATA transcription factors, is highly expressed in duodenum and jejunum but is nearly undetectable in distal ileum of adult mice...
  42. Smagulova F, Manuylov N, Leach L, Tevosian S. GATA4/FOG2 transcriptional complex regulates Lhx9 gene expression in murine heart development. BMC Dev Biol. 2008;8:67 pubmed publisher
    b>GATA4 and FOG2 proteins are required for normal cardiac development in mice...
  43. Liang Q, De Windt L, Witt S, Kimball T, Markham B, Molkentin J. The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo. J Biol Chem. 2001;276:30245-53 pubmed
    The zinc finger-containing transcription factors GATA4 and GATA6 are important regulators of basal and inducible gene expression in cardiac and smooth muscle cell types...
  44. Bruneau B, Nemer G, Schmitt J, Charron F, Robitaille L, Caron S, et al. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell. 2001;106:709-21 pubmed
  45. Zhou B, Ma Q, Rajagopal S, Wu S, Domian I, RIVERA FELICIANO J, et al. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008;454:109-13 pubmed publisher
  46. Singh M, Li Y, Li S, Cobb R, Zhou D, Lu M, et al. Gata4 and Gata5 cooperatively regulate cardiac myocyte proliferation in mice. J Biol Chem. 2010;285:1765-72 pubmed publisher
    ..3 that encodes both zinc finger domains (Gata5(tm)(2)(Eem)), and we show that although Gata5(-/-) mice are viable, Gata4(+/-)5(-/-) mutants die at mid-gestation and exhibit profound cardiovascular defects, including abnormalities of ..
  47. Kusaka M, Katoh Fukui Y, Ogawa H, Miyabayashi K, Baba T, Shima Y, et al. Abnormal epithelial cell polarity and ectopic epidermal growth factor receptor (EGFR) expression induced in Emx2 KO embryonic gonads. Endocrinology. 2010;151:5893-904 pubmed publisher
    ..Our results strongly suggest that Emx2 is required for regulation of tight junction assembly and allowing migration of the gonadal epithelia to the mesenchyme, which are possibly mediated by suppression of Egfr expression...
  48. Kiiveri S, Liu J, Westerholm Ormio M, Narita N, Wilson D, Voutilainen R, et al. Differential expression of GATA-4 and GATA-6 in fetal and adult mouse and human adrenal tissue. Endocrinology. 2002;143:3136-43 pubmed
    ..To clarify the significance of GATA-4 for early adrenocortical development, Gata4-/- ES cells were injected into eight-cell-stage embryos derived from ROSA26 mice, a transgenic line expressing ..
  49. Song L, Yan W, Chen X, Deng C, Wang Q, Jiao K. Myocardial smad4 is essential for cardiogenesis in mouse embryos. Circ Res. 2007;101:277-85 pubmed
    ..In conclusion, this study provides the first mouse model showing that Smad4 plays essential roles during cardiogenesis. ..
  50. Nakajima K, Inagawa M, Uchida C, Okada K, Tane S, Kojima M, et al. Coordinated regulation of differentiation and proliferation of embryonic cardiomyocytes by a jumonji (Jarid2)-cyclin D1 pathway. Development. 2011;138:1771-82 pubmed publisher
    ..Jmj/cyclin D1 double mutant mice showed that Jmj was required for normal differentiation and normal expression of GATA4 protein through cyclin D1...
  51. Wat M, Beck T, Hernandez Garcia A, Yu Z, Veenma D, Garcia M, et al. Mouse model reveals the role of SOX7 in the development of congenital diaphragmatic hernia associated with recurrent deletions of 8p23.1. Hum Mol Genet. 2012;21:4115-25 pubmed publisher
    Recurrent microdeletions of 8p23.1 that include GATA4 and SOX7 confer a high risk of both congenital diaphragmatic hernia (CDH) and cardiac defects...
  52. Ackerman K, Wang J, Luo L, Fujiwara Y, Orkin S, Beier D. Gata4 is necessary for normal pulmonary lobar development. Am J Respir Cell Mol Biol. 2007;36:391-7 pubmed
    ..a missense mutation in Gata6 were structurally normal, while lungs from embryos carrying mutations of either Gata4 or of both Gata4 and Gata6 had a structural phenotype that matched the Fog2 mutant phenotype...
  53. Bosse T, Fialkovich J, Piaseckyj C, Beuling E, Broekman H, Grand R, et al. Gata4 and Hnf1alpha are partially required for the expression of specific intestinal genes during development. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1302-14 pubmed
    ..in mature mouse jejunum, we have previously shown that a member of the zinc finger transcription factor family (Gata4) and hepatocyte nuclear factor-1alpha (Hnf1alpha) are each indispensable for LPH and Fabp1 gene expression but are ..
  54. Liu Z, Li T, Liu Y, Jia Z, Li Y, Zhang C, et al. WNT signaling promotes Nkx2.5 expression and early cardiomyogenesis via downregulation of Hdac1. Biochim Biophys Acta. 2009;1793:300-11 pubmed publisher
    ..Overexpression of Hdac1 inhibited cardiomyocyte formation and downregulated the expressions of Gata4 and Nkx2.5. Mimicking induction of the WNT pathway inhibited Hdac1 expression with upregulated Nkx2.5 expression...
  55. Messerschmidt D, Kemler R. Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism. Dev Biol. 2010;344:129-37 pubmed publisher
    ..EPI and PE formation depend on the activity of the transcription factors Nanog and Gata4/6...
  56. Nemer G, Nemer M. Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6. Dev Biol. 2003;254:131-48 pubmed
    ..They also raise the possibility that part of the early defects in GATA-4 and/or GATA-6 null embryos may be due to impaired BMP-4 signaling. ..
  57. Jacobsen C, Mannisto S, Porter Tinge S, Genova E, Parviainen H, Heikinheimo M, et al. GATA-4:FOG interactions regulate gastric epithelial development in the mouse. Dev Dyn. 2005;234:355-62 pubmed
    ..To show that GATA-4:FOG interactions influence stomach development, we analyzed Gata4(ki/ki) mice, which express a mutant GATA-4 that cannot bind FOG cofactors...
  58. Mattiske D, Kume T, Hogan B. The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development. Dev Biol. 2006;290:447-58 pubmed
    ..We conclude that alongside its previously known roles in kidney, cardiovascular and eye development, Foxc1 has essential functions during at least two stages of gonad development-germ cell migration and folliculogenesis. ..
  59. Rajagopal S, Ma Q, Obler D, Shen J, Manichaikul A, Tomita Mitchell A, et al. Spectrum of heart disease associated with murine and human GATA4 mutation. J Mol Cell Cardiol. 2007;43:677-85 pubmed
    The transcription factor GATA4 is essential for heart morphogenesis. Heterozygous mutation of GATA4 causes familial septal defects. However, the phenotypic spectrum of heterozygous GATA4 mutation is not known...
  60. Han M, Yang Z, Sayed D, He M, Gao S, Lin L, et al. GATA4 expression is primarily regulated via a miR-26b-dependent post-transcriptional mechanism during cardiac hypertrophy. Cardiovasc Res. 2012;93:645-54 pubmed publisher
    b>GATA4 is a transcription factor that is up-regulated during cardiac hypertrophy and plays a fundamental role in myocyte growth and survival. In this study, we investigate the transcriptional vs...
  61. Molkentin J, Lin Q, Duncan S, Olson E. Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 1997;11:1061-72 pubmed
    The zinc finger transcription factor GATA4 has been implicated in heart development based on its early expression in precardiogenic splanchnic mesoderm and its ability to activate the expression of a number of cardiac-specific genes...
  62. Fujikura J, Yamato E, Yonemura S, Hosoda K, Masui S, Nakao K, et al. Differentiation of embryonic stem cells is induced by GATA factors. Genes Dev. 2002;16:784-9 pubmed
    ..We believe that this is the first report of a physiological differentiation event induced by the ectopic expression of a transcription factor in ES cells. ..
  63. Hirose T, Karasawa M, Sugitani Y, Fujisawa M, Akimoto K, Ohno S, et al. PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains. Development. 2006;133:1389-98 pubmed
    ..These results also provide a clear example of the proper organization of epithelial tissues through the regulation of individual cell polarity. ..
  64. Manuylov N, Zhou B, Ma Q, Fox S, Pu W, Tevosian S. Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation. Dev Biol. 2011;353:229-41 pubmed publisher
    Assembly of functioning testis and ovary requires a GATA4-FOG2 transcriptional complex...
  65. Xuan S, Borok M, Decker K, Battle M, Duncan S, Hale M, et al. Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. J Clin Invest. 2012;122:3516-28 pubmed publisher
    ..Recently, mutations in GATA6 have been identified in a large percentage of human cases, and a GATA4 mutant allele has been implicated in a single case...
  66. Hu Y, Okumura L, Page D. Gata4 is required for formation of the genital ridge in mice. PLoS Genet. 2013;9:e1003629 pubmed publisher
    ..We report that the transcription factor GATA4 is expressed in the coelomic epithelium of the genital ridge, progressing in an anterior-to-posterior (A-P) ..
  67. Saga Y, Miyagawa Tomita S, Takagi A, Kitajima S, Miyazaki J, Inoue T. MesP1 is expressed in the heart precursor cells and required for the formation of a single heart tube. Development. 1999;126:3437-47 pubmed
    ..These results strongly suggest that MesP1 is expressed in the heart tube precursor cells and is required for mesodermal cells to depart from the primitive streak and to generate a single heart tube. ..
  68. Alder O, Lavial F, Helness A, Brookes E, Pinho S, Chandrashekran A, et al. Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment. Development. 2010;137:2483-92 pubmed publisher
  69. Wu G, Han D, Gong Y, Sebastiano V, Gentile L, Singhal N, et al. Establishment of totipotency does not depend on Oct4A. Nat Cell Biol. 2013;15:1089-97 pubmed publisher
  70. Roebroek A, Umans L, Pauli I, Robertson E, Van Leuven F, Van de Ven W, et al. Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin. Development. 1998;125:4863-76 pubmed
    ..Overall, the present data identify Furin as an important activator of signals responsible for ventral closure and embryonic turning. ..
  71. Capo Chichi C, Rula M, Smedberg J, Vanderveer L, Parmacek M, Morrisey E, et al. Perception of differentiation cues by GATA factors in primitive endoderm lineage determination of mouse embryonic stem cells. Dev Biol. 2005;286:574-86 pubmed
    ..This study indicates that the lineage differentiation of ES cells can be manipulated by the expression of GATA factors. ..
  72. Laforest B, Nemer M. GATA5 interacts with GATA4 and GATA6 in outflow tract development. Dev Biol. 2011;358:368-78 pubmed publisher
    ..the GATA family of transcription factors are critical regulators of heart development and mutations in 2 of them, GATA4 and GATA6 are associated with outflow tract and septal defects in human...
  73. Kim E, Chen L, Ma Y, Yu W, Chang J, Moskowitz I, et al. Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction. J Mol Cell Cardiol. 2012;52:638-49 pubmed publisher
    ..5 in vivo. Our findings indicate the indispensability of a balanced SUMO pathway for proper cardiac development and function. This article is part of a Special Issue entitled 'Post-translational Modification SI'. ..
  74. Do D, Ueda J, Messerschmidt D, Lorthongpanich C, Zhou Y, Feng B, et al. A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo. Genes Dev. 2013;27:1378-90 pubmed publisher
    ..These results provide a novel genetic model of cell fate determination operating through STAT3 in the preimplantation embryo and pluripotent stem cells in vivo. ..
  75. Schrode N, Saiz N, Di Talia S, Hadjantonakis A. GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. Dev Cell. 2014;29:454-67 pubmed publisher
    ..This study provides a framework for quantitative analyses of mammalian embryos and establishes GATA6 as a nodal point in the gene regulatory network driving ICM lineage specification. ..
  76. Kawamura T, Ono K, Morimoto T, Wada H, Hirai M, Hidaka K, et al. Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes. J Biol Chem. 2005;280:19682-8 pubmed
    ..5 promoter and of endogenous cardiac beta-myosin heavy chain during the differentiation. These findings demonstrate that acetylation of GATA-4 as well as of histones is involved in the differentiation of ES cells into cardiac myocytes. ..
  77. Oka T, Maillet M, Watt A, Schwartz R, Aronow B, Duncan S, et al. Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability. Circ Res. 2006;98:837-45 pubmed
    The transcription factor GATA4 is a critical regulator of cardiac gene expression where it controls embryonic development, cardiomyocyte differentiation, and stress responsiveness of the adult heart...
  78. Beuling E, Bosse T, aan de Kerk D, Piaseckyj C, Fujiwara Y, Katz S, et al. GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors. Dev Biol. 2008;322:179-89 pubmed publisher
    b>GATA4, a transcription factor expressed in the proximal small intestine but not in the distal ileum, maintains proximal-distal distinctions by multiple processes involving gene repression, gene activation, and cell fate determination...
  79. Niakan K, Ji H, Maehr R, Vokes S, Rodolfa K, Sherwood R, et al. Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 2010;24:312-26 pubmed publisher
    ..By elaborating the function of Sox17, our results provide insight into how the transcriptional network promoting ES cell self-renewal is interrupted, allowing cellular differentiation. ..
  80. Wang Y, Smedberg J, Cai K, Capo Chichi D, Xu X. Ectopic expression of GATA6 bypasses requirement for Grb2 in primitive endoderm formation. Dev Dyn. 2011;240:566-76 pubmed publisher
    ..underwent endoderm differentiation as indicated by the expression of the extraembryonic endoderm markers Dab2 and GATA4. Transfection of GATA4 expression vector also had the same differentiation potency...
  81. Frum T, Halbisen M, Wang C, Amiri H, Robson P, Ralston A. Oct4 cell-autonomously promotes primitive endoderm development in the mouse blastocyst. Dev Cell. 2013;25:610-22 pubmed publisher
    ..Finally, we show that Oct4 is required for the expression of multiple EPI and PE genes as well as multiple metabolic pathways essential for the continued growth of the preimplantation embryo. ..
  82. Lickert H, Kutsch S, Kanzler B, Tamai Y, Taketo M, Kemler R. Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm. Dev Cell. 2002;3:171-81 pubmed
    ..We provide evidence that ablation of beta-catenin in embryonic endoderm changes cell fate from endoderm to precardiac mesoderm, consistent with the existence of bipotential mesendodermal progenitors in mouse embryos. ..
  83. Watt A, Zhao R, Li J, Duncan S. Development of the mammalian liver and ventral pancreas is dependent on GATA4. BMC Dev Biol. 2007;7:37 pubmed
    ..b>GATA4, a zinc finger transcription factor, is strongly expressed in these endodermal domains and molecular analyses have ..
  84. Beuling E, Baffour Awuah N, Stapleton K, Aronson B, Noah T, Shroyer N, et al. GATA factors regulate proliferation, differentiation, and gene expression in small intestine of mature mice. Gastroenterology. 2011;140:1219-1229.e1-2 pubmed publisher
    GATA transcription factors regulate proliferation, differentiation, and gene expression in multiple organs. GATA4 is expressed in the proximal 85% of the small intestine and regulates the jejunal-ileal gradient in absorptive enterocyte ..
  85. Yang D, Smith E, Roland I, Sheng Z, He J, Martin W, et al. Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis. Dev Biol. 2002;251:27-44 pubmed
    ..We suggest that Dab2 functions in a signal pathway to regulate endodermal cell organization using endocytosis of ligands from the blastocoel cavity as a positioning cue. ..
  86. Watt A, Battle M, Li J, Duncan S. GATA4 is essential for formation of the proepicardium and regulates cardiogenesis. Proc Natl Acad Sci U S A. 2004;101:12573-8 pubmed
    The role of GATA4 during the earliest stages of cardiogenesis has not been defined because Gata4 knockout embryos suffer an early developmental arrest caused by deficiencies in extraembryonic visceral endoderm function...
  87. Ottolenghi C, Omari S, Garcia Ortiz J, Uda M, Crisponi L, Forabosco A, et al. Foxl2 is required for commitment to ovary differentiation. Hum Mol Genet. 2005;14:2053-62 pubmed
    ..This suggests the possible continued involvement of sex-determining genes in maintaining ovarian function throughout female reproductive life. ..
  88. Thurisch B, Liang S, Sarioglu N, Schomburg L, BUNGERT J, Dame C. Transgenic mice expressing small interfering RNA against Gata4 point to a crucial role of Gata4 in the heart and gonads. J Mol Endocrinol. 2009;43:157-69 pubmed publisher
    Homozygous deficiency of the transcription factor Gata4 in mice causes lethality due to defects in ventral morphogenesis and heart tube formation...
  89. Rojas A, Schachterle W, Xu S, Martin F, Black B. Direct transcriptional regulation of Gata4 during early endoderm specification is controlled by FoxA2 binding to an intronic enhancer. Dev Biol. 2010;346:346-55 pubmed publisher
    ..the transcription factors that have been shown to be important for endoderm development and gut morphogenesis is GATA4. Despite the important role of GATA4 in endoderm development, its transcriptional regulation is not well ..
  90. Ketola I, Rahman N, Toppari J, Bielinska M, Porter Tinge S, Tapanainen J, et al. Expression and regulation of transcription factors GATA-4 and GATA-6 in developing mouse testis. Endocrinology. 1999;140:1470-80 pubmed
    ..In light of these results, we propose that transcription factors GATA-4 and GATA-6 play differing roles in the maturation and function of testicular somatic cells. ..
  91. Takeuchi J, Mileikovskaia M, Koshiba Takeuchi K, Heidt A, Mori A, Arruda E, et al. Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development. 2005;132:2463-74 pubmed
    ..Tbx20 synergized with Isl1 and Gata4 to activate both the Mef2c and Nkx2-5 enhancers, thus providing a unifying mechanism for gene activation by Tbx20 ..
  92. Manuylov N, Fujiwara Y, Adameyko I, Poulat F, Tevosian S. The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models. Dev Biol. 2007;307:356-67 pubmed
    We have previously established an in vivo requirement for GATA4 and FOG2 transcription factors in sexual differentiation...
  93. Shimosato D, Shiki M, Niwa H. Extra-embryonic endoderm cells derived from ES cells induced by GATA factors acquire the character of XEN cells. BMC Dev Biol. 2007;7:80 pubmed
    ..and ES cell-derived ExEn cell lines remains unclear, although we have previously reported that overexpression of Gata4 or Gata6 induces differentiation of mouse ES cells into extra-embryonic endoderm in vitro...
  94. Zhao R, Watt A, Battle M, Li J, Bondow B, Duncan S. Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. Dev Biol. 2008;317:614-9 pubmed publisher
    ..Candidates include the zinc finger transcription factors GATA binding proteins 4 and 6 (GATA4, GATA6)...
  95. Holtzinger A, Rosenfeld G, Evans T. Gata4 directs development of cardiac-inducing endoderm from ES cells. Dev Biol. 2010;337:63-73 pubmed publisher
    The transcription factor Gata4 is essential for normal heart morphogenesis and regulates the survival, growth, and proliferation of cardiomyocytes...
  96. Mazaud Guittot S, Bouchard M, Robert Grenon J, Robert C, Goodyer C, Silversides D, et al. Conserved usage of alternative 5' untranslated exons of the GATA4 gene. PLoS ONE. 2009;4:e8454 pubmed publisher
    b>GATA4 is an essential transcription factor required for the development and function of multiple organs. Despite this important role, our knowledge of how the GATA4 gene is regulated remains limited...
  97. Ieda M, Fu J, Delgado Olguin P, Vedantham V, Hayashi Y, Bruneau B, et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell. 2010;142:375-86 pubmed publisher
    ..Here, we report that a combination of three developmental transcription factors (i.e., Gata4, Mef2c, and Tbx5) rapidly and efficiently reprogrammed postnatal cardiac or dermal fibroblasts directly into ..
  98. Brown C, Chi X, Garcia Gras E, Shirai M, Feng X, Schwartz R. The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer. J Biol Chem. 2004;279:10659-69 pubmed
    ..In mammalian two hybrid assays, Smad factors recruited the hybrid gene GATA4-VP16 to strongly drive transcription of a reporter gene containing multimerized Smad binding sites These cofactors ..
  99. Bisping E, Ikeda S, Kong S, Tarnavski O, Bodyak N, McMullen J, et al. Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure. Proc Natl Acad Sci U S A. 2006;103:14471-6 pubmed
    ..In cultured cardiomyocytes, the transcription factor Gata4 is required for agonist-induced hypertrophy...
  100. Yang D, Cai K, Roland I, Smith E, Xu X. Disabled-2 is an epithelial surface positioning gene. J Biol Chem. 2007;282:13114-22 pubmed
    ..Thus, the findings indicate that Dab2 is a surface positioning gene and suggest a novel mechanism of epithelial cell surface targeting. ..