Gata3

Summary

Gene Symbol: Gata3
Description: GATA binding protein 3
Alias: Gata-3, jal, GATA-binding factor 3, GATA-binding protein 3, trans-acting T-cell-specific transcription factor GATA-3
Species: mouse

Top Publications

  1. ncbi Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment
    Valerie P I Vidal
    Inserm U636, Centre de Biochimie, Faculte des Sciences, Parc Valrose, 06108 Nice, France
    Curr Biol 15:1340-51. 2005
  2. ncbi Transcription factor GATA-3 is required for development of the T-cell lineage
    C N Ting
    The Departments of Medicine and Pathology, University of Chicago, Illinois 60637, USA
    Nature 384:474-8. 1996
  3. pmc An NK and T cell enhancer lies 280 kilobase pairs 3' to the gata3 structural gene
    Sakie Hosoya-Ohmura
    Department of Cell and Developmental Biology, 3071 BSRB, 109 Zina Pitcher Place, University of Michigan Medical School, Ann Arbor, MI 48103, USA
    Mol Cell Biol 31:1894-904. 2011
  4. pmc Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti
    Ning Pan
    University of Iowa, Department of Biology, 143 BB, Iowa City, IA 52242, USA
    Hear Res 275:66-80. 2011
  5. ncbi Gata2 specifies serotonergic neurons downstream of sonic hedgehog
    Sarah E Craven
    Department of Molecular Biology, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Development 131:1165-73. 2004
  6. doi Lack of Gata3 results in conotruncal heart anomalies in mouse
    Raivo Raid
    Department of Developmental Biology, University of Tartu, Tartu, Estonia
    Mech Dev 126:80-9. 2009
  7. ncbi Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo
    M C Nawijn
    Department of Immunology, Faculty of Medicine, Erasmus University Rotterdam, Dr Molewaterplein 50, 3000 DR Rotterdam, The Netherlands
    J Immunol 167:724-32. 2001
  8. ncbi Essential role of Gata transcription factors in sympathetic neuron development
    Konstantina Tsarovina
    Max Planck Institut für Hirnforschung, Abteilung Neurochemie, Deutschordenstr 46, 60528 Frankfurt Main, Germany
    Development 131:4775-86. 2004
  9. pmc Genomic analysis of the function of the transcription factor gata3 during development of the mammalian inner ear
    Marta Milo
    NIHR Cardiovascular Biomedical Research Unit, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom
    PLoS ONE 4:e7144. 2009
  10. ncbi T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    Eun Sook Hwang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 307:430-3. 2005

Scientific Experts

Detail Information

Publications126 found, 100 shown here

  1. ncbi Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment
    Valerie P I Vidal
    Inserm U636, Centre de Biochimie, Faculte des Sciences, Parc Valrose, 06108 Nice, France
    Curr Biol 15:1340-51. 2005
    ..However, factors required for the differentiation of this critical cell lineage remain to be identified. Here, we describe an unexpected role of the HMG-box-containing gene Sox9 in hair development...
  2. ncbi Transcription factor GATA-3 is required for development of the T-cell lineage
    C N Ting
    The Departments of Medicine and Pathology, University of Chicago, Illinois 60637, USA
    Nature 384:474-8. 1996
    ..These findings suggest that GATA-3 is an essential and specific regulator of early thymocyte development...
  3. pmc An NK and T cell enhancer lies 280 kilobase pairs 3' to the gata3 structural gene
    Sakie Hosoya-Ohmura
    Department of Cell and Developmental Biology, 3071 BSRB, 109 Zina Pitcher Place, University of Michigan Medical School, Ann Arbor, MI 48103, USA
    Mol Cell Biol 31:1894-904. 2011
    ..for multiple stages of T cell and natural killer (NK) cell development, and yet the factors that directly regulate Gata3 transcription during hematopoiesis are only marginally defined...
  4. pmc Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti
    Ning Pan
    University of Iowa, Department of Biology, 143 BB, Iowa City, IA 52242, USA
    Hear Res 275:66-80. 2011
    ..This pattern of innervation by sensory neurons is maintained at least until P14, but fibers target the few Myo7a positive cells found in later stages...
  5. ncbi Gata2 specifies serotonergic neurons downstream of sonic hedgehog
    Sarah E Craven
    Department of Molecular Biology, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Development 131:1165-73. 2004
    ..2 and Nkx6.1 cooperate to induce the closely related zinc-finger transcription factors Gata2 and Gata3. Gata2 in turn is necessary and sufficient to activate the transcription factors Lmx1b and Pet1, and to induce 5-..
  6. doi Lack of Gata3 results in conotruncal heart anomalies in mouse
    Raivo Raid
    Department of Developmental Biology, University of Tartu, Tartu, Estonia
    Mech Dev 126:80-9. 2009
    The transcription factor Gata3 is an important regulator of the development of thymus, the nervous system, ear, kidney, and adrenal glands...
  7. ncbi Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo
    M C Nawijn
    Department of Immunology, Faculty of Medicine, Erasmus University Rotterdam, Dr Molewaterplein 50, 3000 DR Rotterdam, The Netherlands
    J Immunol 167:724-32. 2001
    ..To study the function of GATA-3 during T cell-mediated immune responses in vivo, we investigated CD2-GATA3-transgenic mice in which GATA-3 expression is driven by the CD2 locus control region...
  8. ncbi Essential role of Gata transcription factors in sympathetic neuron development
    Konstantina Tsarovina
    Max Planck Institut für Hirnforschung, Abteilung Neurochemie, Deutschordenstr 46, 60528 Frankfurt Main, Germany
    Development 131:4775-86. 2004
    ..Here, we have studied the function of Gata2 and Gata3 zinc-finger transcription factors in autonomic neuron development...
  9. pmc Genomic analysis of the function of the transcription factor gata3 during development of the mammalian inner ear
    Marta Milo
    NIHR Cardiovascular Biomedical Research Unit, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom
    PLoS ONE 4:e7144. 2009
    We have studied the function of the zinc finger transcription factor gata3 in auditory system development by analysing temporal profiles of gene expression during differentiation of conditionally immortal cell lines derived to model ..
  10. ncbi T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    Eun Sook Hwang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Science 307:430-3. 2005
    ..These results provide a novel function for tyrosine phosphorylation of a transcription factor in specifying alternate fates of a common progenitor cell...
  11. pmc GATA3 is selectively expressed in the trophectoderm of peri-implantation embryo and directly regulates Cdx2 gene expression
    Pratik Home
    Institute of Maternal Fetal Biology, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 284:28729-37. 2009
    ..In this study, we demonstrate that during early mouse development, mRNA expression of transcription factor GATA3 is induced at the 4-cell stage and is consistently present during pre-implantation embryonic development...
  12. ncbi GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet
    Takashi Usui
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 18:415-28. 2003
    ..These findings reassert that Stat4 signaling is a central element of Th1/Th2 development...
  13. pmc Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3
    Tom Taghon
    Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent University, 9000 Ghent, Belgium
    Nat Immunol 8:845-55. 2007
    ..Our results suggest a close relationship between the pro-T cell and mast cell programs and a previously unknown function for Notch in T lineage fidelity...
  14. ncbi Hearing loss following Gata3 haploinsufficiency is caused by cochlear disorder
    Jacqueline van der Wees
    Department of Cell Biology, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Neurobiol Dis 16:169-78. 2004
    ..from hypoparathyroidism, deafness, and renal dysplasia due to a heterozygous deletion of the transcription factor GATA3. Since GATA3 is prominently expressed in both the inner ear and different parts of the auditory nervous system, it ..
  15. pmc GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland
    Hosein Kouros-Mehr
    Department of Anatomy and the Biomedical Sciences Program, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cell 127:1041-55. 2006
    ..This suggests that GATA-3 actively maintains luminal epithelial differentiation in the adult mammary gland, which raises important implications for the pathogenesis of breast cancer...
  16. pmc Dynamic patterning at the pylorus: formation of an epithelial intestine-stomach boundary in late fetal life
    Xing Li
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Dev Dyn 238:3205-17. 2009
    ..Finally, we define a unique expression domain at the pylorus itself and detect novel pylorus-specific patterns for the transcription factor Gata3 and the secreted protein nephrocan.
  17. pmc Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system
    Yuka Morikawa
    Department of Cell and Molecular Biology, Tulane University, 2000 Percival Stern Hall, New Orleans, LA 70118, USA
    Dev Biol 307:114-26. 2007
    ..Our data suggest that the major role of Hand2 during SNS development is to permit sympathetic neurons to acquire a catecholaminergic phenotype...
  18. ncbi Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses
    Jinfang Zhu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 5:1157-65. 2004
    ..Here, we generated a conditional GATA-3-deficient mouse line. In vitro deletion of Gata3 diminished both interleukin 4 (IL-4)-dependent and IL-4-independent T(H)2 cell differentiation; without GATA-3, T(..
  19. ncbi Critical roles for transcription factor GATA-3 in thymocyte development
    Sung Yun Pai
    Department of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Children s Hospital, Boston, MA 02115, USA
    Immunity 19:863-75. 2003
    ..Thus, our data demonstrate that the coordinated and regulated expression of GATA-3 at each stage of thymic development is critical for the generation of mature T cells...
  20. ncbi GATA3 haploinsufficiency causes a rapid deterioration of distortion product otoacoustic emissions (DPOAEs) in mice
    M A J Van Looij
    Department of ENT, Erasmus Medical Center, PO Box 2060, 3000 CB Rotterdam, The Netherlands
    Neurobiol Dis 20:890-7. 2005
    ..deafness and renal dysplasia)-syndrome is caused by haploinsufficiency of zinc-finger transcription factor GATA3. The hearing loss due to GATA3 haploinsufficiency has been shown to be peripheral in origin, but it is unclear to ..
  21. pmc Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
    Derk Amsen
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 27:89-99. 2007
    ..GATA-3 was necessary for Notch-induced Th2 differentiation, and we identified an upstream Gata3 promoter as a direct target for Notch signaling...
  22. pmc Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors
    Alexandre Pattyn
    Department of Cell and Molecular Biology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Genes Dev 17:729-37. 2003
    ..These findings assign new roles for Nkx, Hox, and Phox2 proteins in the control of temporal neuronal fate determination, and link spatial and temporal patterning of CNS neuronal fates...
  23. doi Defects in sensory organ morphogenesis and generation of cochlear hair cells in Gata3-deficient mouse embryos
    Maarja Haugas
    Department of Veterinary Biosciences, University of Helsinki, Agnes Sjöbergin katu 2, 00790 Helsinki, Finland
    Hear Res 283:151-61. 2012
    ..b>GATA3 is a DNA-binding factor that is necessary for otic morphogenesis and without GATA3 variable defects have been ..
  24. pmc Localization of distant urogenital system-, central nervous system-, and endocardium-specific transcriptional regulatory elements in the GATA-3 locus
    G Lakshmanan
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    Mol Cell Biol 19:1558-68. 1999
    ....
  25. pmc Gata3 is a critical regulator of cochlear wiring
    Jessica M Appler
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 33:3679-91. 2013
    ..Here, we show that the transcription factor Gata3, which is expressed in SGNs throughout their development, is essential for formation of the intricately patterned ..
  26. ncbi Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
    Marie Liesse Asselin-Labat
    VBCRC Laboratory, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Cell Biol 9:201-9. 2007
    ..These studies provide evidence for the existence of an epithelial hierarchy within the mammary gland and establish Gata-3 as a critical regulator of luminal differentiation...
  27. ncbi The role of Pax2 in mouse inner ear development
    Quianna Burton
    National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
    Dev Biol 272:161-75. 2004
    ....
  28. ncbi Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system
    K C Lim
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois, USA
    Nat Genet 25:209-12. 2000
    Mouse embryos deficient in Gata3 die by 11 days post coitum (d.p.c.) from pathology of undetermined origin...
  29. pmc Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3
    Cristina de Guzman Strong
    National Human Genome Research Institute and 2National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 175:661-70. 2006
    ..Comparison of these animal models illustrates how impairment of the skin barrier by two genetically distinct mechanisms leads to innate immune responses, as observed in the common human skin disorders psoriasis and atopic dermatitis...
  30. ncbi Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus
    R W Hendriks
    Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus University Rotterdam, The Netherlands
    Eur J Immunol 29:1912-8. 1999
    ..We therefore propose that GATA-3 is required for the expansion of T cell progenitors, and for the control of subsequent proliferation steps, which alternate periods of TCR recombination in the thymus...
  31. ncbi GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation
    Gabriela Hernandez-Hoyos
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Immunity 19:83-94. 2003
    ..We propose that GATA-3 contributes to linking the TCR signal strength to the differentiation program of CD4 and CD8 thymocytes...
  32. pmc Notch directly regulates Gata3 expression during T helper 2 cell differentiation
    Terry C Fang
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Immunity 27:100-10. 2007
    ..In the absence of Notch signals, Gata3 expression was markedly diminished...
  33. pmc Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA
    Krzysztof Kobielak
    Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021 6399, USA
    J Cell Biol 163:609-23. 2003
    ....
  34. ncbi Transcriptional regulation of GATA-3 by an intronic regulatory region and fetal liver zinc finger protein 1
    Eun Sook Hwang
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 169:248-53. 2002
    ..Our data suggest that the expression of GATA-3 might be partly regulated by the intronic regulatory region and Fliz1 in a developmental stage-specific fashion...
  35. pmc GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells
    Sung Yun Pai
    Department of Pediatric Hematology Oncology, Dana Farber Cancer Institute and Children s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:1993-8. 2004
    ..Using a conditional knockout approach, we found that GATA-3 is required for optimal Th2 cytokine production in vitro and in vivo. Our data also show that GATA-3 expression must be sustained to maintain the Th2 phenotype...
  36. ncbi Lim 1 is required for nephric duct extension and ureteric bud morphogenesis
    Anissa Pedersen
    Department of Genetics, Cell Biology and Development and University of Minnesota Developmental Biology Center, University of Minnesota, 6 160 Jackson Hall, 321 Church St SE, Minneapolis, MN 55455, USA
    Dev Biol 288:571-81. 2005
    ..These results suggest that Lim 1 influences nephric duct extension and ureteric bud outgrowth by regulating and or maintaining the differentiation of the nephric epithelium...
  37. ncbi Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling
    Zhengshi Lin
    Laboratory of Molecular Biology, National Institutes on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20850, USA
    Development 132:2309-18. 2005
    ..However, Gbx2 promotes ventral fates such as the saccule and cochlear duct, possibly by restricting Otx2 expression...
  38. pmc GATA-3: an unexpected regulator of cell lineage determination in skin
    Charles K Kaufman
    Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    Genes Dev 17:2108-22. 2003
    ..This newfound function for GATA-3 in skin development strengthens the parallels between the differentiation programs governing hair follicle and lymphocyte differentiation...
  39. pmc c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3
    Diane Maurice
    Institute of Cancer Research, Cancer Research UK Centre for Cell and Molecular Biology, London, UK
    EMBO J 26:3629-40. 2007
    ..In c-Myb-null thymocytes, Gata3, a critical inducer of T-helper cell fate, is not upregulated in response to T-cell receptor signaling, following ..
  40. pmc Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons
    Tyler J Hendershot
    Department of Neurosciences, Program in Neurosciences and Degenerative Disease, University of Toledo Health Sciences Center, Toledo, OH 43614, USA
    Dev Biol 319:179-91. 2008
    ..by affecting both the proliferative capacity of the progenitors as well as affecting expression of Phox2a and Gata3, DNA binding proteins important for the cell autonomous development of noradrenergic neurons...
  41. pmc Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2
    Irina V Grigorieva
    Academic Endocrine Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism OCDEM, Churchill Hospital, Headington, Oxford, United Kingdom
    J Clin Invest 120:2144-55. 2010
    Heterozygous mutations of GATA3, which encodes a dual zinc-finger transcription factor, cause hypoparathyroidism with sensorineural deafness and renal dysplasia...
  42. ncbi GATA-3 regulates the development and function of invariant NKT cells
    Peter J Kim
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 177:6650-9. 2006
    ..In addition, GATA-3 is also required for survival, activation, and effector functions of this unique population of T cells. Our data also reveal a previously unidentified peripheral maturation step that is GATA-3 dependent...
  43. ncbi Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci
    Masakatsu Yamashita
    PRESTO Project, Japan Science and Technology Corporation, Department of Immunology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana Chuo ku, Chiba 260 8670, Japan
    J Biol Chem 279:26983-90. 2004
    b>GATA3 expression is essential for type-2 helper T (Th2) cell differentiation...
  44. ncbi Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis
    John Jacob
    Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Neurosci 10:1433-9. 2007
    ..Moreover, the subsequent differentiation of central serotonergic neurons required both the suppression of VMN neurogenesis and the induction of downstream intrinsic determinants of serotonergic identity by Foxa2...
  45. ncbi Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney
    David Grote
    McGill Cancer Centre and Biochemistry Department, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    Development 133:53-61. 2006
    ..screen for genes specifically expressed in the pro/mesonephros and regulated by Pax proteins, we identified Gata3, a transcription factor gene associated with hypoparathyroidism, deafness and renal anomaly (HDR) syndrome...
  46. ncbi Differential expression of LIM domain-only (LMO) genes in the developing mouse inner ear
    Min Deng
    Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
    Gene Expr Patterns 6:857-63. 2006
    ..Thus, the regionalized expression patterns of LMO1-4 are closely associated with the morphogenesis of the inner ear...
  47. doi Notch signaling is necessary for GATA3 function in the initiation of T cell development
    Katsuto Hozumi
    Department of Immunology, and Research Center for Embryogenesis and Organogenesis, Tokai University School of Medicine, Isehara, Japan
    Eur J Immunol 38:977-85. 2008
    b>GATA3 and Notch1 are essential for T cell development at the earliest stage, but their mutual roles in this process remain to be clarified...
  48. pmc T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription
    Takashi Usui
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Disease NIAID, National Institutes of Health NIH, Bethesda, MD 20892, USA
    J Exp Med 203:755-66. 2006
    ..Thus, the principal function of T-bet in developing Th1 cells is to negatively regulate GATA-3 rather than to positively regulate the IFNG gene...
  49. ncbi Gata3 participates in a complex transcriptional feedback network to regulate sympathoadrenal differentiation
    Takashi Moriguchi
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 0616, USA
    Development 133:3871-81. 2006
    b>Gata3 mutant mice expire of noradrenergic deficiency by embryonic day (E) 11 and can be rescued pharmacologically or, as shown here, by restoring Gata3 function specifically in sympathoadrenal (SA) lineages using the human DBH promoter ..
  50. pmc Dlx3 is a crucial regulator of hair follicle differentiation and cycling
    Joonsung Hwang
    Developmental Skin Biology Unit, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Development 135:3149-59. 2008
    ..upstream regulator of other transcription factors that regulate hair follicle differentiation, such as Hoxc13 and Gata3. Colocalization of phospho-Smad1/5/8 and Dlx3 is consistent with a regulatory role for BMP signaling to Dlx3 ..
  51. doi Transcriptional regulation of GATA3 in T helper cells by the integrated activities of transcription factors downstream of the interleukin-4 receptor and T cell receptor
    Eyal J Scheinman
    Department of Immunology Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Biol Chem 284:3037-48. 2009
    b>GATA3 is a critical transcription factor for many developmental processes. During T helper (Th) cell differentiation, GATA3 induces the Th2 and suppresses the Th1 pathway...
  52. pmc Canonical notch signaling functions as a commitment switch in the epidermal lineage
    Cedric Blanpain
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Genes Dev 20:3022-35. 2006
    ....
  53. ncbi Critical YxKxHxxxRP motif in the C-terminal region of GATA3 for its DNA binding and function
    Ryo Shinnakasu
    Department of Immunology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Immunol 177:5801-10. 2006
    A zinc finger transcription factor, GATA3, plays an essential role in the development of T cells and the functional differentiation into type 2 Th cells...
  54. pmc Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction
    David Grote
    Goodman Cancer Centre, McGill University, Quebec, Canada
    PLoS Genet 4:e1000316. 2008
    ..Here, we show that the nephric duct-specific inactivation of the transcription factor gene Gata3 leads to massive ectopic ureter budding...
  55. pmc Dosage-dependent rescue of definitive nephrogenesis by a distant Gata3 enhancer
    Susan L Hasegawa
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109 0616, USA
    Dev Biol 301:568-77. 2007
    Human GATA3 haploinsufficiency leads to HDR (hypoparathyroidism, deafness and renal dysplasia) syndrome, demonstrating that the development of a specific subset of organs in which this transcription factor is expressed is exquisitely ..
  56. ncbi A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127
    Christian A J Vosshenrich
    Unité des Cytokines et Développement Lymphoide, Institut National de la Santé et de la Recherche Médicale U668, Institut Pasteur, Paris F 75724, France
    Nat Immunol 7:1217-24. 2006
    ..We propose that bone marrow and thymic NK cell pathways generate distinct mouse NK cells with properties similar to those of the two human CD56 NK cell subsets...
  57. ncbi Dynamic expression of Runx1 in skin affects hair structure
    Eli Raveh
    Department of Cell and Animal Biology, Silberman Life Sciences Institute, Edmond Safra Campus at Givat Ram, The Hebrew University, Jerusalem 91904, Israel
    Mech Dev 123:842-50. 2006
    ..The data delineate Runx1 as a novel specific marker of several hair follicle cell types and sheds light on its role in hair morphogenesis and differentiation...
  58. ncbi Gata3 is required for early morphogenesis and Fgf10 expression during otic development
    Kersti Lilleväli
    Institute of Biotechnology, University of Helsinki, Viikinkaari 9, 00710 Helsinki, Finland
    Mech Dev 123:415-29. 2006
    ..Inner ear morphogenesis is severely affected in Gata3 deficient mouse embryos, but the onset and basis of the phenotype has not been known...
  59. ncbi GATA3 is downregulated during hair cell differentiation in the mouse cochlea
    M N Rivolta
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    J Neurocytol 27:637-47. 1998
    b>GATA3 is a transcription factor expressed in the inner ear during the early stages of development...
  60. ncbi Suppression of neural fate and control of inner ear morphogenesis by Tbx1
    Steven Raft
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 131:1801-12. 2004
    ..We propose that Tbx1 acts in the manner of a selector gene to control neural and sensory organ fate specification in the otocyst...
  61. ncbi Ventral otic cell lines as developmental models of auditory epithelial and neural precursors
    G Lawoko-Kerali
    Department of Biomedical Sciences, Addison Building, Western Bank, Sheffield, United Kingdom
    Dev Dyn 231:801-14. 2004
    ..Selection was based upon dissection, tissue-specific markers, and expression of the transcription factor GATA3. Two cell lines expressed GATA3 but possessed intrinsically different genetic programs under differentiating ..
  62. ncbi Partially overlapping expression of Gata2 and Gata3 during inner ear development
    Kersti Lilleväli
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Dev Dyn 231:775-81. 2004
    Gata2 and Gata3 belong to the Gata family of transcription factors in vertebrates that bind to a consensus "GATA" DNA sequence. The Gata3 gene is one of the earliest markers for the developing mouse inner ear...
  63. ncbi gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis
    Yonghua Pan
    Department of Molecular Biology and Pharmacology, Division of Dermatology, Washington University School of Medicine, Box 8103, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Cell 7:731-43. 2004
    ....
  64. pmc Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer
    L J Ko
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208 3500
    Mol Cell Biol 11:2778-84. 1991
    ..We infer that the murine and human GATA-3 proteins play a central and highly conserved role in vertebrate T-cell-specific transcriptional regulation...
  65. ncbi Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear
    A Karis
    Department of Animal Development and Systematics, University of Tartu, 51014 Tartu, Estonia
    J Comp Neurol 429:615-30. 2001
    ..This study shows for the first time that a zinc finger factor is involved in axonal navigation of the inner ear efferent neurons and, simultaneously, in the morphogenesis of the inner ear...
  66. ncbi Expression of the transcription factors GATA3 and Pax2 during development of the mammalian inner ear
    Grace Lawoko-Kerali
    Institute of Molecular Physiology, Sheffield, S10 2TN, United Kingdom
    J Comp Neurol 442:378-91. 2002
    The transcription factors GATA3 and Pax2 are expressed throughout development of the mouse inner ear. We have used antibodies to study their temporal and spatial expression patterns from embryonic days E8-E16.5...
  67. pmc The Runx1 transcription factor inhibits the differentiation of naive CD4+ T cells into the Th2 lineage by repressing GATA3 expression
    Okiru Komine
    Research Institute for Biological Sciences, Tokyo University of Science, Noda, Japan
    J Exp Med 198:51-61. 2003
    ..wild-type T cells caused a complete attenuation of Th2 differentiation and was accompanied by the cessation of GATA3 expression...
  68. ncbi Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system
    J Nardelli
    Cytosquelette et Développement, CNRS URA 2115, CHU Pitie Salpetriere, 105 Boulevard de l Hôpital, Paris Cedex, 75 634, France
    Dev Biol 210:305-21. 1999
    ....
  69. ncbi Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3
    D H Zhang
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 11:473-82. 1999
    ..Thus, targeting GATA-3 activity alone is sufficient to blunt Th2 responses in vivo, thereby establishing GATA-3 as a potential therapeutic target in the treatment of asthma and allergic diseases...
  70. ncbi Cutting edge: Identification of an alternative GATA-3 promoter directing tissue-specific gene expression in mouse and human
    Helene Asnagli
    Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 168:4268-71. 2002
    ..These results indicate that similar to other GATA factors, the GATA-3 gene can be controlled by two promoters that may direct lineage- and tissue-specific expression...
  71. ncbi Definition of regulatory network elements for T cell development by perturbation analysis with PU.1 and GATA-3
    Michele K Anderson
    Division of Biology, California Institute of Technology, Pasadena 91125, USA
    Dev Biol 246:103-21. 2002
    ..The target genes identified here provide insight into the basis of the effects of GATA-3 or PU.1 overexpression and into the regulatory changes that distinguish the developmental time windows for these effects...
  72. ncbi Embryonic expression and cloning of the murine GATA-3 gene
    K M George
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500
    Development 120:2673-86. 1994
    ..Furthermore, this same region of the locus confers developmentally appropriate expression in transgenic mice, but only in a subset of the tissues that naturally express the gene...
  73. ncbi Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis
    P P Pandolfi
    Dept of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Nat Genet 11:40-4. 1995
    ..Mice heterozygous for the GATA3 mutation are fertile and appear in all respects to be normal, whereas homozygous mutant embryos die between days ..
  74. ncbi GATA3 and NeuroD distinguish auditory and vestibular neurons during development of the mammalian inner ear
    Grace Lawoko-Kerali
    Department of Biomedical Sciences, Institute of Molecular Physiology, Addison Building, Western Bank, Sheffield S10 2TN, UK
    Mech Dev 121:287-99. 2004
    The function of the zinc finger transcription factor GATA3 was studied in a newly established, conditionally immortal cell line derived to represent auditory sensory neuroblasts migrating from the mouse otic vesicle at embryonic day E10...
  75. pmc T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma
    Qing Yu
    Lymphocyte Development Unit, Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    Nat Immunol 10:992-9. 2009
    ..differentiation, was induced by T cell factor 1 (TCF-1) and its cofactor beta-catenin, mainly from the proximal Gata3 promoter upstream of exon 1b...
  76. ncbi GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nuclei
    J H van Doorninck
    Departments of Cell Biology and Genetics and Anatomy, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Neurosci 19:RC12. 1999
    ..In sum, we conclude that GATA-3 plays a major role in the development of the serotonergic neurons of the caudal raphe nuclei, and that it is crucial for their role in locomotion...
  77. ncbi Coexpression of SCL and GATA3 in the V2 interneurons of the developing mouse spinal cord
    Emma Smith
    Institute for Molecular Bioscience, incorporating the Special Research Centre for Functional and Applied Genomics, The University of Queensland, Brisbane, Australia
    Dev Dyn 224:231-7. 2002
    ..These experiments revealed that SCL is expressed in a medially restricted subpopulation of GATA-3 producing cells, suggesting a possible role for this factor in the differentiation of the GATA population of V2 interneurons...
  78. pmc Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression
    Saleha R Farooqui-Kabir
    Cardiovascular Division, King s College London School of Medicine, Department of Cardiology, The Rayne Institute, St Thomas s Hospital, Lambeth Palace Road, London, UK
    Cell Stress Chaperones 13:297-312. 2008
    ..Loss of Brn-3a was correlated with a compensatory increase in Brn-3b and GATA3 mRNA but no change in Hsp27 mRNA...
  79. ncbi GATA-3 directly remodels the IL-10 locus independently of IL-4 in CD4+ T cells
    John Shoemaker
    Division of Immunoregulation, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom
    J Immunol 176:3470-9. 2006
    ..We therefore suggest a key role of GATA-3 in instructing Il-10 gene expression in primary CD4+ T cells, possibly by switching and stabilizing the Il-10 locus into a transcriptionally competent status...
  80. pmc Cyclic AMP-induced chromatin changes support the NFATc-mediated recruitment of GATA-3 to the interleukin 5 promoter
    Stefan Klein-Hessling
    Department of Molecular Pathology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Biol Chem 283:31030-7. 2008
    ..These data demonstrate the functional importance of cyclic AMP signals for the interplay between GATA-3 and NFATc factors in the transcriptional control of lymphokine expression in Th2 effector cells...
  81. ncbi Lmx1b is essential for the development of serotonergic neurons
    Yu Qiang Ding
    Department of Anesthesiology, School of Medicine Pain Center, Washington University, St Louis, Missouri 63110, USA
    Nat Neurosci 6:933-8. 2003
    ..Moreover, our data indicate that genetic cascades controlling the caudal and rostral 5-HT neurons are distinct, despite their shared components...
  82. pmc CDK inhibitor p18(INK4c) is a downstream target of GATA3 and restrains mammary luminal progenitor cell proliferation and tumorigenesis
    Xin Hai Pei
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
    Cancer Cell 15:389-401. 2009
    ..We demonstrate that GATA3 binds to and represses INK4C transcription...
  83. ncbi Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice
    M C Nawijn
    Department of Immunology, Faculty of Medicine, Erasmus University Rotterdam, Dr Molewaterplein 50, 3000 DR Rotterdam, The Netherlands
    J Immunol 167:715-23. 2001
    ..In two independent CD2-GATA3-transgenic lines, approximately 50% of the mice developed thymic lymphoblastoid tumors that were CD4(+)CD8(+/low) ..
  84. doi Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons
    Kaia Kala
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Development 136:253-62. 2009
    ..These studies identify Gata2 as an essential post-mitotic selector gene of the GABAergic neurotransmitter identity and demonstrate developmental heterogeneity of GABAergic neurons in the midbrain...
  85. pmc AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis
    Xuan Wang
    The Howard Hughes Medical Institute and Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA
    J Cell Biol 183:37-48. 2008
    ....
  86. doi IL4 blockade of inducible regulatory T cell differentiation: the role of Th2 cells, Gata3 and PU.1
    Suzana Hadjur
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK
    Immunol Lett 122:37-43. 2009
    ..In addition, we find that Foxp3 induction is efficiently blocked not only by the Th2 transcription factor Gata3, but also by PU.1, which is transiently induced during Th2 differentiation...
  87. pmc Context-dependent function of regulatory elements and a switch in chromatin occupancy between GATA3 and GATA2 regulate Gata2 transcription during trophoblast differentiation
    Soma Ray
    Institute of Maternal Fetal Biology and the Division of Cancer and Developmental Biology, Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 284:4978-88. 2009
    ..GATA transcription factors are important regulators of tissue-specific gene expression during development. GATA2 and GATA3 have been implicated in the regulation of trophoblast-specific genes...
  88. pmc Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment
    Xuexian O Yang
    Department of Immunology, MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 10:1260-6. 2009
    ..As GATA-3 induces Dec2 expression, our findings also indicate a feed-forward regulatory circuit during T(H)2 differentiation...
  89. pmc LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons
    Kaumudi Joshi
    Department of Molecular Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 61:839-51. 2009
    ..Thus, LMO4 plays essential roles in directing a balanced generation of inhibitory and excitatory neurons in the ventral spinal cord...
  90. pmc Spatiotemporally separable Shh domains in the midbrain define distinct dopaminergic progenitor pools
    Milan Joksimovic
    Northwestern University Feinberg School of Medicine, Department of Neurology and Center for Genetic Medicine, 7 113 Lurie Building, 303 East Superior Street, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:19185-90. 2009
    ..This refined ontogenetic definition will expand understanding of dopamine neuron biology and selective susceptibility, and will impact stem cell-derived therapies and models for PD...
  91. doi Detailed expression pattern of Foxp1 and its possible roles in neurons of the spinal cord during embryogenesis
    Yoshihiro Morikawa
    Department of Anatomy and Neurobiology, Wakayama Medical University, Wakayama, Japan
    Dev Neurosci 31:511-22. 2009
    ..in the intermediate zone throughout the ventral spinal cord, all of which were Pax2(+), En1(+), Evx1(-), Chx10(-), Gata3(-), and Lhx3(-) V1 interneurons...
  92. pmc Smad4-dependent desmoglein-4 expression contributes to hair follicle integrity
    Philip Owens
    Department of Otolaryngology, Oregon Health Sciences University, Portland, OR 97239, USA
    Dev Biol 322:156-66. 2008
    ..Thus, Smad4 loss-associated Dsg4 depletion contributed, at least in part, to hair follicles degeneration in Smad4 deficient skin...
  93. doi Gene expression profiling in mice with enforced Gata3 expression reveals putative targets of Gata3 in double positive thymocytes
    Jan Piet van Hamburg
    Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
    Mol Immunol 46:3251-60. 2009
    The zinc-finger transcription factors Gata3 and ThPOK have both been implicated in positive selection of double positive (DP) thymocytes towards the CD4 lineage...
  94. pmc Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity
    Mi Ryoung Song
    Bioimaging Research Center and Cell Dynamics Research Center, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea
    Development 136:2923-32. 2009
    ....
  95. doi Characterization of Foxp2-expressing cells in the developing spinal cord
    Y Morikawa
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1, Kimiidera, Wakayama 641 8509, Japan
    Neuroscience 162:1150-62. 2009
    ..homeodomain transcription factors revealed that Foxp2-expressing neurons were Pax2(+), En1(+), Evx1(-), Chx10(-), Gata3(-), and Lhx3(-) V1 interneurons in the intermediate zone throughout the ventral spinal cord, indicating that Foxp2-..
  96. ncbi Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types
    J S Dasen
    Howard Hughes Medical Institute, Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla 92093 0648, USA
    Cell 97:587-98. 1999
    ....
  97. pmc Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation
    Vanesa Esteban
    Cellular Biology in Renal Diseases Laboratory, Fundacion Jimenez Diaz, Universidad Autonoma Madrid, Madrid, Spain
    PLoS ONE 4:e5406. 2009
    ..Therefore, the blockade of the NF-kappaB-activating properties of the receptor Mas could be a new strategy in the therapy of failing kidney...
  98. pmc Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation
    Nicolas Charles
    Laboratory of Immune Cell Signaling, NIAMS, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 30:533-43. 2009
    ..Our findings demonstrate that basophil-expressed Lyn kinase exerts regulatory control on Th2 cell differentiation and function...
  99. ncbi GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo
    G T Ma
    Department of Biochemistry, Northwestern University, Evanston, Illinois 60208, USA
    Development 124:907-14. 1997
    ....
  100. pmc Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord
    Shengguo Li
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 102:10688-93. 2005
    ..However, coexpression of both Foxn4 and Mash1 promotes the V2b fate while inhibiting the V2a fate, indicating that Foxn4 cooperates with Mash1 to specify the identity of V2b neurons from bipotential p2 progenitors...
  101. ncbi Transduction of graded Hedgehog signaling by a combination of Gli2 and Gli3 activator functions in the developing spinal cord
    Qiubo Lei
    Department of Neuroscience and Cell Biology, UMDNJ Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Development 131:3593-604. 2004
    ..Thus, multiple ventral neuronal types can develop in the absence of Gli function, but require balanced Gli protein activities for their correct patterning and differentiation...

Research Grants12

  1. Role of BCL-6 in Allergic Immune Responses
    Alexander Dent; Fiscal Year: 2005
    ..These studies will also provide insight into the function of BCL6, which may help the treatment of B cell lymphoma. ..
  2. A preclinical trial of intratympanic antivirals for CMV-related hearing loss
    Daniel I Choo; Fiscal Year: 2010
    ..Given the tremendous potential patient population of infants with congenital CMV infection and SNHL, it is compelling to pursue these studies and develop new therapies that are safe and effective. ..
  3. A preclinical trial of intratympanic antivirals for CMV-related hearing loss
    Daniel Choo; Fiscal Year: 2007
    ..Given the tremendous potential patient population of infants with congenital CMV infection and SNHL, it is compelling to pursue these studies and develop new therapies that are safe and effective. ..
  4. Molecular Development of the Endolymphatic Duct and Sac
    Daniel Choo; Fiscal Year: 2005
    ..Significantly, this proposal includes challenging but achievable goals that will provide important knowledge to the field of inner ear development. ..
  5. A preclinical trial of intratympanic antivirals for CMV-related hearing loss
    Daniel Choo; Fiscal Year: 2009
    ..Given the tremendous potential patient population of infants with congenital CMV infection and SNHL, it is compelling to pursue these studies and develop new therapies that are safe and effective. ..