Genomes and Genes
Gene Symbol: Gast
- Glycine-extended gastrin synergizes with gastrin 17 to stimulate acid secretion in gastrin-deficient miceD Chen
Department of Surgery and Laboratory Medicine, Trondheim University Hospital, Trondheim, Norway
Gastroenterology 119:756-65. 2000..We examined the effects of these 2 forms of gastrin on acid secretion in gastrin-deficient mice...
- Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencingHiroyuki Tomita
Division of Digestive and Liver Disease, Irving Cancer Research Center, Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
Gastroenterology 140:879-91. 2011..Although hormones have been associated with cancer risk, the mechanisms have not been determined. The peptide hormone gastrin exerts a suppressive effect on antral gastric carcinogenesis...
- Induction of follistatin precedes gastric transformation in gastrin deficient miceWeiqun Kang
Department of Internal Medicine, University of Michigan, 109 Zina Pitcher Place, BSRB 2051, Ann Arbor, MI 48109 2200, USA
Biochem Biophys Res Commun 376:573-7. 2008We previously showed that antral gastric tumors develop in gastrin-deficient (Gas(-/-)) mice. Therefore Gas(-/-) mice were studied sequentially over 12 months to identify molecular mechanisms underlying gastric transformation...
- Lessons from genetically engineered animal models. I. Physiological studies with gastrin in transgenic miceT C Wang
Gastrointestinal Unit and Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Am J Physiol 277:G6-11. 1999..This themes article highlights recent progress in our understanding of the biology of gastrin through studies in genetically modified mice...
- Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformationYana Zavros
Department of Internal Medicine Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Biol Chem 282:33265-74. 2007..Moreover parietal cell atrophy, a known pre-neoplastic lesion, correlates with loss of Shh processing...
- Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinomaYana Zavros
Department of Gastroenterology, University of Michigan, Ann Arbor, MI 48109 0650, USA
Oncogene 24:2354-66. 2005..Moreover, neoplastic transformation of the antral gastric mucosa does not require gastrin...
- Interferon gamma induction of gastric mucous neck cell hypertrophyWeiqun Kang
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
Lab Invest 85:702-15. 2005....
- Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancerT C Wang
Gastrointestinal Unit and Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Gastroenterology 118:36-47. 2000..Hypergastrinemia occurs frequently in association with acid suppression and Helicobacter infection, but its role in the progression to gastric atrophy and gastric cancer has not been well defined...
- Gastrin stimulates the growth of gastric pit cell precursors by inducing its own receptorsToshio Nakajima
Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
Am J Physiol Gastrointest Liver Physiol 282:G359-66. 2002..Thus these findings suggest that gastrin directly stimulates the growth of the pit cell lineage by inducing its own receptor in pit cell precursors...
- Gastrin is an essential cofactor for helicobacter-associated gastric corpus carcinogenesis in C57BL/6 miceShigeo Takaishi
Division of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, New York, USA
Am J Pathol 175:365-75. 2009..However, gastrin-deficient (GAS-KO) mice on a mixed C57BL/6/129Sv genetic background maintained in conventional housing were reported to develop ..
- Impaired gastric acid secretion in gastrin-deficient miceL Friis-Hansen
Department of Physiology, University of Michigan, Ann Arbor 48109, USA
Am J Physiol 274:G561-8. 1998..The results show that gastrin is critically important for the function of the acid secretory system...
- Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasiaMilena Saqui-Salces
Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS ONE 7:e48039. 2012Chronic inflammation in the stomach can lead to gastric cancer. We previously reported that gastrin-deficient (Gast⁻/⁻) mice develop bacterial overgrowth, inflammatory infiltrate, increased Il-1β expression, antral hyperplasia and ..
- Arx is required for normal enteroendocrine cell development in mice and humansAiping Du
Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, USA
Dev Biol 365:175-88. 2012..Taken together, our findings uncover a novel and conserved role of Arx in mammalian endocrine cell development and provide a potential cause for the chronic diarrhea seen in both humans and mice carrying Arx mutations...
- Insulin-promoter-factor 1 is required for pancreas development in miceJ Jonsson
Department of Microbiology, University of Umea, Sweden
Nature 371:606-9. 1994..These findings show that IPF1 is needed for the formation of the pancreas and suggest that it acts to determine the fate of common pancreatic precursor cells and/or to regulate their propagation...
- Transgenic insulin released from G cells preferentially signals in the liverYu Chun Lu
Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at UCLA and CURE Digestive Diseases Research Center, Los Angeles, CA 90095, USA
Biochem Biophys Res Commun 355:23-7. 2007..G-InsKi mice provide a novel animal model for elucidating direct effects of insulin on liver functions...
- Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretionSara Edfalk
Umeå Center for Molecular Medicine, University of Umea, Umea, Sweden
Diabetes 57:2280-7. 2008..Here, we addressed whether 1) Gpr40 is expressed in the intestine and 2) Ipf1/Pdx1 function is required for Gpr40 expression...
- Mash1 is required for neuroendocrine cell development in the glandular stomachHiroshi Kokubu
Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
Genes Cells 13:41-51. 2008....
- Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumorsJulie Pannequin
CNRS UMR5203, Montpellier, France
Gastroenterology 133:1554-68. 2007....
- Achlorhydria is associated with gastric microbial overgrowth and development of cancer: lessons learned from the gastrin knockout mouseL Friis-Hansen
Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
Scand J Clin Lab Invest 66:607-21. 2006..Study of these mice helps our understanding of how dysregulation of gastrin secretion may be implicated in human disease...
- Gastrin increases murine intestinal crypt regeneration following injuryPenelope D Ottewell
Division of Gastroenterology, University of Liverpool, Liverpool, UK
Gastroenterology 130:1169-80. 2006..We therefore investigated the effects of gastrin on intestinal regeneration following a range of stimuli...
- Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiationVinciane Vanhorenbeeck
Hormone and Metabolic Research Unit, Université catholique de Louvain and Christian de Duve Institute of Cellular Pathology, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
Dev Biol 305:685-94. 2007..In conclusion, our data reveal partially redundant roles for HNF-6 and OC-2 in developing pancreas and identify new markers for antero-posterior patterning of the gut and for enteroendocrine differentiation...
- Circulating gastrin is increased in hemochromatosisKelly A Smith
University of Melbourne Department of Surgery, Austin Health, Level 8, Lance Townsend Building, Studley Road, Heidelberg, VIC 3084, Australia
FEBS Lett 580:6195-8. 2006..The discovery of a relationship between iron status and circulating gastrin concentrations opens a new perspective on the mechanisms of iron homeostasis...
- Gastrin-induced apoptosis contributes to carcinogenesis in the stomachGuanglin Cui
Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Lab Invest 86:1037-51. 2006Hypergastrinemia in INS-GAS mice leads to accelerated carcinogenesis of the stomach, but the mechanisms have not been well defined...
- Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathwaysShuiping Tu
Division of Digestive and Liver Diseases, Dept of Medicine, College of Physicians and Surgeons, Columbia Univ, 1130 St Nicholas Ave, Rm 925, 9th Fl, New York, NY 10032, USA
Am J Physiol Gastrointest Liver Physiol 292:G1726-37. 2007..TFF2 protein expression in the gastric fundus was elevated in hypergastrinemic (INS-GAS) transgenic mice and reduced in gastrin-deficient mice...
- Significant increase in the aggressive behavior of transgenic mice overexpressing peripheral progastrin peptides: associated changes in CCK2 and serotonin receptors in the CNSQian Li
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77555 0431, USA
Neuropsychopharmacology 32:1813-21. 2007..Our results suggest that an upregulation of the CCK response system and 5-HT(1A)R in the hypothalamus of Tg/Tg mice may mediate the alterations in the observed behaviors of these mice...
- Impairment of gastric acid secretion and increase of embryonic lethality in Foxq1-deficient miceW Goering
Institute of Human Genetics, University of Gottingen, Gottingen, Germany
Cytogenet Genome Res 121:88-95. 2008..Ultrastructural analysis suggests that the gastric acid secretion defect in Foxq1-deficient mice might be due to impairment in the fusion of cytoplasmic tubulovesicles to the apical membrane of secretory canaliculi...
- Gastrin-deficient mice have disturbed hematopoiesis in response to iron deficiencySuzana Kovac
University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria 3084, Australia
Endocrinology 152:3062-73. 2011..Here we report the effect of long-term dietary iron modification on gastrin-deficient (Gas(-/-)) and hypergastrinemic cholecystokinin receptor 2-deficient (Cck2r(-/-)) mice, both of which have reduced basal ..
- Altered gene expression and spongiotrophoblast differentiation in placenta from a mouse model of diabetes in pregnancyJ M Salbaum
Laboratory of Regulation of Gene Expression, Pennington Biomedical Research Center, Baton Rouge, LA, USA
Diabetologia 54:1909-20. 2011..g. metabolic syndrome and hypertension. We hypothesised that adverse outcomes from diabetic pregnancies may be linked to compromised placental function, and sought to identify cellular and molecular abnormalities in diabetic placenta...
- Regulation of mouse stomach development and Barx1 expression by specific microRNAsByeong Moo Kim
Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA
Development 138:1081-6. 2011..These results indicate that miRNAs are required for proper digestive tract organogenesis and that miR-7a and miR-203 control expression of the stomach homeotic regulator Barx1...
- In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic miceShigeo Takaishi
Division of Digestive and Liver Disease, Dept of Medicine, Columbia Univ Medical Center, 1130 St Nicholas Ave, ICRC 923, New York, NY, USA
Am J Physiol Gastrointest Liver Physiol 300:G334-44. 2011..This transgenic mouse provides a useful tool to study the regulation of mouse gastrin gene in vivo, thus contributing to our understanding of the mechanisms involved in transcriptional control of the gastrin gene...
- Cholecystokinin (CCK)-expressing neurons in the suprachiasmatic nucleus: innervation, light responsiveness and entrainment in CCK-deficient miceJens Hannibal
Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
Eur J Neurosci 32:1006-17. 2010....
- Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survivalGeorg Mellitzer
Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM U964, CNRS UMR 7104, Universite de Strasbourg, Illkirch, France
J Clin Invest 120:1708-21. 2010..Our data help unravel the role of enteroendocrine cells and hormones in lipid absorption and maintenance of the intestinal epithelium...
- Immunocytochemical detection of orexin A in endocrine cells of the developing mouse gutMaría J Sánchez de Miguel
Department of Histology and Pathology, University of Navarra, Pamplona, Spain
J Histochem Cytochem 50:63-9. 2002..These findings suggest that orexin A may be relevant in the growth and maturation of the gastrointestinal tract during intrauterine life...
- Functional cross-talk between beta-catenin and NFkappaB signaling pathways in colonic crypts of mice in response to progastrinShahid Umar
Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
J Biol Chem 284:22274-84. 2009..Our studies suggest a novel possibility that activation of beta-catenin, downstream to the IKKalpha,beta/NFkappaB pathway, may be integral to the hyperproliferative effects of progastrin on proximal colonic crypts...
- Growth of human pancreatic cancer is inhibited by down-regulation of gastrin gene expressionGail L Matters
Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17011, USA
Pancreas 38:e151-61. 2009..This study evaluated the effects of gastrin messenger RNA (mRNA) down-regulation on growth of human pancreatic cancer...
- Altered gastric chief cell lineage differentiation in histamine-deficient miceKoji Nozaki
Vanderbilt Univ Sch of Medicine, Dept of Surgery, Epithelial Biology Center, MRBIV Bm 10435G, 2213 Garland Ave, Nashville, TN 37232, USA
Am J Physiol Gastrointest Liver Physiol 296:G1211-20. 2009..Nevertheless, histamine is not required for emergence of SPEM following acute oxyntic atrophy...
- Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumorsYu Cheng Wang
UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA
Endocr Relat Cancer 16:267-79. 2009..2 functions in immature endocrine cells to control NE differentiation in normal intestine and is expressed in most NE tumors of the gut, and is therefore a novel target of diagnosis for patients with gastrointestinal NE tumors...
- Hip1r is expressed in gastric parietal cells and is required for tubulovesicle formation and cell survival in miceRenu N Jain
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
J Clin Invest 118:2459-70. 2008..Taken together, these studies demonstrate that Hip1r plays a significant role in gastric physiology, mucosal architecture, and secretory membrane dynamics in parietal cells...
- Interrelationships between circulating gastrin and iron status in mice and humansSuzana Kovac
Univ of Melbourne Dept of Surgery, Austin Health, Studley Rd, Heidelberg, Victoria 3084, Australia
Am J Physiol Gastrointest Liver Physiol 295:G855-61. 2008..004) with an increased transferrin saturation. Our data indicate that, in juvenile animals when iron demand is high, circulating gastrin concentrations may alter iron status by a CCK2R-independent mechanism...
- Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cellsMichael P Verzi
Dana Farber Cancer Institute and Department of Medicine, Boston, Massachusetts, USA
Gastroenterology 135:591-600. 2008..We identified stomach-restricted expression of the forkhead transcription factor FOXQ1...
- Attenuation of peroxisome proliferator-activated receptor gamma (PPARgamma) mediates gastrin-stimulated colorectal cancer cell proliferationAlbert J Chang
Section of Gastroenterology, Boston University School of Medicine and Boston Medical Center, 650 Albany Street, Boston, MA 02118, USA
J Biol Chem 281:14700-10. 2006....
- Development of a deer mouse whole-genome radiation hybrid panel and comparative mapping of Mus chromosome 11 lociClifton M Ramsdell
Peromyscus Genetic Stock Center, Department of Biological Sciences, University of South Carolina, 700 Sumter Street, Columbia, South Carolina 29208, USA
Mamm Genome 17:37-48. 2006..Furthermore, this separate linkage group is likely to reside in a chromosomal region of inversion polymorphism between P. maniculatus and P. polionotus...
- Cloning and analysis of Nkx6.3 during CNS and gastrointestinal developmentTomas Alanentalo
Umeå Centre for Molecular Medicine, UCMM, Umea University, S 901 87 Umea, Sweden
Gene Expr Patterns 6:162-70. 2006..2 both in the CNS and in the gut. Transient Nkx6.2 expression was also detected in the developing pancreas. However, analysis of Nkx6.2(-/-) mice did not display any obvious aberrations of pancreatic or stomach development...
- Chronic Helicobacter pylori infection results in gastric hypoacidity and hypergastrinemia in wild-type mice but vagally induced hypersecretion in gastrin-deficient miceChun Mei Zhao
Departments of Cancer Research and Molecular Medicine and Laboratory Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Regul Pept 115:161-70. 2003..pylori infection results to impaired parietal-cell function (acid hyposecretion), hypergastrinemia and hyperplasia of ECL cells in wild-type mice but leads to vagally induced hypersecretion in gastrin-deficient mice...
- Enhanced calcium signaling and acid secretion in parietal cells isolated from gastrin-deficient miceKaren L Hinkle
Department of Physiology, University of Michigan, Ann Arbor 48109 0622, USA
Am J Physiol Gastrointest Liver Physiol 284:G145-53. 2003..Parietal cells were found to be significantly smaller in the mutant cell preparations, suggesting that gastrin stimulation modulates parietal cell morphology...
- Potential role of endocrine gastrin in the colonic adenoma carcinoma sequenceS A Watson
Academic Unit of Cancer Studies, University of Nottingham, Nottingham, NG7 2UH, UK
Br J Cancer 87:567-73. 2002..The effect of hypergastrinaemia on tumour growth was reversed by use of antiserum directed against the CCK-2 receptor. Hyper-gastrinaemia may promote proliferation of human colonic adenomas that express CCK-2 receptor isoforms...
- Gastrin interferes with the differentiation of gastric pit cells and parietal cellsT Nakajima
Division of Gastroenterology and Hepatology, Kyoto University, Graduate School of Medicine, Sakyo ku 606 8507, Japan
Aliment Pharmacol Ther 16:3-9. 2002..Gastrin is known to have stimulatory effects on gastric mucosa; however, long-term effect of gastrin stimulation is not well known...
- Requirement of Math1 for secretory cell lineage commitment in the mouse intestineQ Yang
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Science 294:2155-8. 2001..The continuous rapid renewal of these cells makes the intestinal epithelium a model system for the study of stem cell regeneration and lineage commitment...
- Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11P Liu
Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Genetics 150:1155-68. 1998..A duplication corresponding to one of these two deficiencies was able to rescue its haplolethality...
- Disturbed progastrin processing in carboxypeptidase E-deficient fat miceK A Lacourse
Department of Physiology, University of Michigan, Ann Arbor 48109 0622, USA
FEBS Lett 416:45-50. 1997..Hence, the increase of glycine-extended gastrin in combination with normal levels of carboxyamidated gastrin suggests that G-cells may have another biosynthetic pathway for gastrin...
- G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivoA Nagata
Department of Medicine, Kobe University School of Medicine, Japan
Proc Natl Acad Sci U S A 93:11825-30. 1996..These results clearly demonstrated that the G protein-coupled CCK-B/gastrin receptor is essential for the physiological as well as pathological proliferation of gastric mucosal cells in vivo...
- Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cellsT C Wang
Department of Medicine, Massachusetts General Hospital, Boston 02114
J Clin Invest 92:1349-56. 1993..This transgenic study suggests that islet neogenesis can be reactivated in the ductular epithelium of the adult pancreas by local expression of two growth factors, gastrin and TGF alpha...
- Sequences responsible for transcription termination of the mouse gastrin geneM J Noh
Department of Life Science, Korea Advanced Institute of Science and Technology, Taejon
Biochem Mol Biol Int 35:1205-13. 1995....
- Gastrin regulates the heparin-binding epidermal-like growth factor promoter via a PKC/EGFR-dependent mechanismNatalie F Sinclair
University of Massachusetts Memorial Medical Center, Division of Digestive Diseases and Nutrition, Worcester, 01655, USA
Am J Physiol Gastrointest Liver Physiol 286:G992-9. 2004..The cis-acting element mediating gastrin responsiveness was mapped to the -69 to -58 region of the HB-EGF promoter. Gastrin stimulation was PKC dependent and at least partially mediated by activation of the EGF receptor...
- Acidic duodenal pH alters gene expression in the cystic fibrosis mouse pancreasSimran Kaur
Dept of Anatomy and Cell Biology, Univ of Kansas School of Medicine, Kansas City, KS 66160, USA
Am J Physiol Gastrointest Liver Physiol 287:G480-90. 2004..It is concluded that the acidic duodenal pH in CF contributes to the stress on the exocrine pancreas and that normalizing duodenal pH reduces this stress...
- Growth factors associated with gastric mucosal hypertrophy in autoimmune gastritisTeo V Franic
The Russell Grimwade School of Biochemistry and Molecular Biology, The Univ of Melbourne, Melbourne, VIC 3010, Australia
Am J Physiol Gastrointest Liver Physiol 287:G910-8. 2004..These findings are likely to be of relevance to other gastric inflammatory conditions...
- Gene expression profiling of gastrin target genes in parietal cellsRenu N Jain
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109 0622, USA
Physiol Genomics 24:124-32. 2006..Hence, the aim of this study was to evaluate changes in the acid-secreting parietal cell in gastrin-deficient (GAS-KO) mice...
- Involvement of cyclooxygenase-2 in gastric mucosal hypertrophy in gastrin transgenic miceNaoki Kanda
Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin Kawara cho 54, Sakyo ku, Kyoto 606 8507, Japan
Am J Physiol Gastrointest Liver Physiol 290:G519-27. 2006..Hypergastrinemic mice [mice with mutated gastrin under the control of the beta-actin promoter (ACT-GAS mice)] received the COX-2 inhibitor celecoxib (0, 200, or 500 mg/kg of diet) from 5 wk of age and were killed at 16 ..
- Direct regulation of intestinal fate by NotchBen Z Stanger
Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 102:12443-8. 2005..In the embryo, Notch activation perturbs morphogenesis, possibly through effects on stem or progenitor cells...
- Reduced ghrelin, islet amyloid polypeptide, and peptide YY expression in the stomach of gastrin-cholecystokinin knockout miceLennart Friis-Hansen
Department of Clinical Biochemistry, KB 3011, Rigshospitalet, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
Endocrinology 146:4464-71. 2005..Both gastrin and combined gastrin-CCK deficiency reduced the gastric IAPP and PYY expression...
- Molecular cloning and sequencing of the murine gastrin geneT J Koh
Gastrointestinal Unit, Massachusetts General Hospital, Boston 02114, USA
Biochem Biophys Res Commun 216:34-41. 1995..Transfection studies demonstrated that the murine gastrin gene expression is stimulated by epidermal growth factor to the same extent as the human gastrin gene...
- Reciprocal changes in trefoil 1 and 2 expression in stomachs of mice with gastric unit hypertrophy and inflammationT V Franic
Department of Medicine, The University of Melbourne, Western Hospital, Melbourne, VIC 3011, Australia
J Pathol 207:43-52. 2005..Additionally, a clear role for inflammation was established involving both polymorphonuclear and mononuclear cells in these models, and a link was found between mucosal hypertrophy and increased interleukin-11 (IL-11) expression...
- COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivoP D Ottewell
Deptartment of Medicine, 5th Fl UCD Bldg, Daulby St, Liverpool L69 3BX, UK
Am J Physiol Gastrointest Liver Physiol 288:G541-9. 2005....
- Abdominal obesity, insulin resistance, and colon carcinogenesis are increased in mutant mice lacking gastrin gene expressionStephanie L Cowey
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555 1043, USA
Cancer 103:2643-53. 2005The authors recently reported that gastrin gene knockout (GAS-KO) mice had an increased risk for colon carcinogenesis in response to azoxymethane (AOM) compared with their wild type (WT) littermates...
- Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferationT J Koh
Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Invest 103:1119-26. 1999..To our knowledge, these studies demonstrate for the first time that G-Gly's contribute to colonic mucosal proliferation in vivo...
- Chromosome engineering in miceR Ramirez-Solis
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Nature 378:720-4. 1995..The availability of mice with defined regions of segmental haploidy will allow their use in genetic screens and enable accurate models of human 'chromosomal' diseases to be generated...
- Reduced effects of amphetamine on prepulse inhibition of startle in gastrin-deficient miceMaarten van den Buuse
Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, VIC 3052, Australia
Neurosci Lett 373:237-42. 2005..These data suggest a role of gastrin in the brain in modulating dopamine release in areas involved in PPI...
- Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expressionDaniel F Boyer
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175, USA
Dev Biol 298:616-31. 2006..These results reveal a role for distal cis-regulatory elements in achieving the correct level of extra-pancreatic Pdx1 expression, which is necessary for the production of duodenal GIP cells and stomach gastrin cells...
- Transcriptional profiling of gastrin-regulated genes in mouse stomachRenu N Jain
Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, Michigan 48109 2200, USA
Physiol Genomics 29:1-12. 2007..Accordingly, gastrin-deficient (GAS-KO) mice have a severe impairment in acid secretion...
- Nested chromosomal deletions induced with retroviral vectors in miceH Su
Program in Developmental Biology, Department of Molecular Genetics, Baylor College of Medicine, Houston, Texas, USA
Nat Genet 24:92-5. 2000..Our approach can be extended to any region of the mouse genome...
- Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposisT J Koh
Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Invest 106:533-9. 2000..The identification of gastrin as a functionally relevant downstream target of the beta-catenin signaling pathway provides a new target for therapeutic modalities in the treatment of colorectal cancer...
- The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signalingByeong Moo Kim
Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Dev Cell 8:611-22. 2005..These results define a transcriptional and signaling pathway of inductive cell interactions in vertebrate organogenesis...
- BAC contig from a 3-cM region of mouse chromosome 11 surrounding Brca1M Pershouse
Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Genomics 69:139-42. 2000..The region described is one of the targets of a large effort to create a series of mice with regional deletions on mouse chromosome 11 (33-80 cM) that can subsequently be subjected to further mutagenesis...
- Lessons from the gastrin and gastrin receptor knockout miceL Friis-Hansen
Dept of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
Scand J Clin Lab Invest Suppl 234:41-6. 2001....
- Regulation of parietal cell migration by gastrin in the mouseC M Kirton
Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, United Kingdom
Am J Physiol Gastrointest Liver Physiol 283:G787-93. 2002..10-30 days after BrdU injection in mice in which the gastrin gene had been deleted by homologous recombination (Gas-KO) and wild-type (C57BL/6) mice. The time course of labeling was similar in the two groups...
- Stem Cells and Gastric CancerTIMOTHY CRAGIN WANG; Fiscal Year: 2010....
- The Function and Regulation of Trefoil Factor Family 2 (TFF2)TIMOTHY CRAGIN WANG; Fiscal Year: 2010..TFF2 is suppressed by the tumor suppressor gene p53, and we will also attempt to show that it is an important downstream target of this tumor suppressor through its activity in regulating the immune system. ..
- Stem Cells and Gastric CancerTimothy Wang; Fiscal Year: 2007....
- Role of Inflamation in Mouse Models of Gastric CancerTimothy Wang; Fiscal Year: 2007..We will test the hypothesis that inhibition of NF-kB in epithelial cell will promote apoptosis and BMDC engraftment. ..
- REGULATION OF HISTIDINE DECARBOXYLASETimothy Wang; Fiscal Year: 2007..Overall, these studies will provide new insights into the regulation of HDC gene expression and enzymatic activity, and its function in the gastric mucosa. ..
- FUNCTION AND REGULATION OF GASTRINTimothy Wang; Fiscal Year: 2007..Overall, these studies will attempt to define the role of progastrin-derived peptides in stem cell regulation and in bridging genetic pathways in colorectal cancer. ..
- Role of Inflamation in Mouse Models of Gastric CancerTIMOTHY CRAGIN WANG; Fiscal Year: 2010..We will test the hypothesis that inhibition of NF-kB in epithelial cell will promote apoptosis and BMDC engraftment. ..
- Stem Cells and Gastric CancerTimothy Wang; Fiscal Year: 2009....
- Role of Inflamation in Mouse Models of Gastric CancerTimothy Wang; Fiscal Year: 2009..We will test the hypothesis that inhibition of NF-kB in epithelial cell will promote apoptosis and BMDC engraftment. ..
- 14th International Symposium on Regulatory PeptidesTimothy Wang; Fiscal Year: 2002..abstract_text> ..
- REGULATION OF HISTIDINE DECARBOXYLASETimothy Wang; Fiscal Year: 2002..elements mediating gastrin responsiveness in the HDC gene have been identified as two novel cis-acting elements (GAS-RE1 and GAS-RE2) which are located in tandem downstream of the transcriptional start site, and bind to 52 kD and 35 ..
- FUNCTION AND REGULATION OF GASTRINTimothy Wang; Fiscal Year: 2000..b) Elucidate whether over-expression of incompletely processed forms of gastrin stimulate colonic proliferation and predispose mice to colonic carcinoma. c) Evaluate the role of gastrin in gastrointestinal tract development. ..
- FUNCTION & REGULATION OF SPASMOLYTIC POLYPEPTIDE/TFF2Timothy Wang; Fiscal Year: 2005..felis models. Overall, these studies will utilize gastric cancer models to explore the function and regulation of SP, and may provide further insight into the biology of mucous neck cells. ..
- Mouse Models of Gastric CancerTimothy Wang; Fiscal Year: 2005..Our group has developed a hypergastrinemic transgenic (insulin-gastrin or INS-GAS) mouse model that shows progression over time to gastric atrophy, intestinal metaplasia, dysplasia and gastric ..