Gast

Summary

Gene Symbol: Gast
Description: gastrin
Alias: GAS
Species: mouse

Top Publications

  1. ncbi Glycine-extended gastrin synergizes with gastrin 17 to stimulate acid secretion in gastrin-deficient mice
    D Chen
    Department of Surgery and Laboratory Medicine, Trondheim University Hospital, Trondheim, Norway
    Gastroenterology 119:756-65. 2000
  2. pmc Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing
    Hiroyuki Tomita
    Division of Digestive and Liver Disease, Irving Cancer Research Center, Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    Gastroenterology 140:879-91. 2011
  3. pmc Induction of follistatin precedes gastric transformation in gastrin deficient mice
    Weiqun Kang
    Department of Internal Medicine, University of Michigan, 109 Zina Pitcher Place, BSRB 2051, Ann Arbor, MI 48109 2200, USA
    Biochem Biophys Res Commun 376:573-7. 2008
  4. ncbi Lessons from genetically engineered animal models. I. Physiological studies with gastrin in transgenic mice
    T C Wang
    Gastrointestinal Unit and Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Physiol 277:G6-11. 1999
  5. ncbi Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation
    Yana Zavros
    Department of Internal Medicine Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:33265-74. 2007
  6. ncbi Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma
    Yana Zavros
    Department of Gastroenterology, University of Michigan, Ann Arbor, MI 48109 0650, USA
    Oncogene 24:2354-66. 2005
  7. ncbi Interferon gamma induction of gastric mucous neck cell hypertrophy
    Weiqun Kang
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Lab Invest 85:702-15. 2005
  8. ncbi Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer
    T C Wang
    Gastrointestinal Unit and Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 118:36-47. 2000
  9. ncbi Gastrin stimulates the growth of gastric pit cell precursors by inducing its own receptors
    Toshio Nakajima
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Am J Physiol Gastrointest Liver Physiol 282:G359-66. 2002
  10. pmc Gastrin is an essential cofactor for helicobacter-associated gastric corpus carcinogenesis in C57BL/6 mice
    Shigeo Takaishi
    Division of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, New York, USA
    Am J Pathol 175:365-75. 2009

Research Grants

  1. Stem Cells and Gastric Cancer
    TIMOTHY CRAGIN WANG; Fiscal Year: 2010
  2. The Function and Regulation of Trefoil Factor Family 2 (TFF2)
    TIMOTHY CRAGIN WANG; Fiscal Year: 2010
  3. Stem Cells and Gastric Cancer
    Timothy Wang; Fiscal Year: 2007
  4. Role of Inflamation in Mouse Models of Gastric Cancer
    Timothy Wang; Fiscal Year: 2007
  5. REGULATION OF HISTIDINE DECARBOXYLASE
    Timothy Wang; Fiscal Year: 2007
  6. FUNCTION AND REGULATION OF GASTRIN
    Timothy Wang; Fiscal Year: 2007
  7. Role of Inflamation in Mouse Models of Gastric Cancer
    TIMOTHY CRAGIN WANG; Fiscal Year: 2010
  8. Stem Cells and Gastric Cancer
    Timothy Wang; Fiscal Year: 2009
  9. Role of Inflamation in Mouse Models of Gastric Cancer
    Timothy Wang; Fiscal Year: 2009
  10. 14th International Symposium on Regulatory Peptides
    Timothy Wang; Fiscal Year: 2002

Scientific Experts

  • Lennart Friis-Hansen
  • T C Wang
  • Maarten van den Buuse
  • Suzana Kovac
  • Clifton M Ramsdell
  • Wolfgang Engel
  • S A Watson
  • Qian Li
  • Jens Hannibal
  • Linda C Samuelson
  • Shigeo Takaishi
  • Juanita L Merchant
  • Renu N Jain
  • Yana Zavros
  • Weiqun Kang
  • Byeong Moo Kim
  • Hiroyuki Tomita
  • Milena Saqui-Salces
  • Kelly S Betz
  • T J Koh
  • G J Dockray
  • Andrea Varro
  • Ramesh A Shivdasani
  • Arthur Shulkes
  • Shuiping Tu
  • Pomila Singh
  • Guanglin Cui
  • Wandong Ai
  • Aiping Du
  • A Varro
  • J M Salbaum
  • Xiangdong Yang
  • Wataru Shibata
  • Guangchun Jin
  • Georg Mellitzer
  • Toshio Nakajima
  • Meghna Waghray
  • C M Kirton
  • Gail L Matters
  • Yu Cheng Wang
  • Koji Nozaki
  • Shahid Umar
  • Gerard Gradwohl
  • Sara Edfalk
  • Hiroshi Kokubu
  • W Goering
  • Michael P Verzi
  • Julie Pannequin
  • Yu Chun Lu
  • Catherine S Chew
  • Vinciane Vanhorenbeeck
  • A Bradley
  • Graham S Baldwin
  • Tomas Alanentalo
  • Naoki Kanda
  • Albert J Chang
  • Daniel F Boyer
  • Penelope D Ottewell
  • Kelly A Smith
  • D Mark Pritchard
  • T V Franic
  • Stephanie L Cowey
  • P D Ottewell
  • Sivaprakash Rathinavelu
  • H Su
  • Theodore J Koh
  • Ben Z Stanger
  • Tsutomu Chiba
  • Yoshitaka Konda
  • Teo V Franic
  • Simran Kaur
  • Natalie F Sinclair
  • Toshiyuki Takeuchi
  • Chun Mei Zhao
  • Karen L Hinkle
  • María J Sánchez de Miguel
  • T Nakajima
  • Annie Han
  • James M Wells
  • Kyle W McCracken
  • Q Yang
  • Li Jyun Syu
  • Erik R Walp
  • Natalie A Terry
  • Natalia A Veniaminova
  • Thomas J Klein
  • Evelyn Covés-Datson
  • Andrzej A Dlugosz
  • CATHERINE LEE MAY
  • Michael Quante

Detail Information

Publications75

  1. ncbi Glycine-extended gastrin synergizes with gastrin 17 to stimulate acid secretion in gastrin-deficient mice
    D Chen
    Department of Surgery and Laboratory Medicine, Trondheim University Hospital, Trondheim, Norway
    Gastroenterology 119:756-65. 2000
    ..We examined the effects of these 2 forms of gastrin on acid secretion in gastrin-deficient mice...
  2. pmc Inhibition of gastric carcinogenesis by the hormone gastrin is mediated by suppression of TFF1 epigenetic silencing
    Hiroyuki Tomita
    Division of Digestive and Liver Disease, Irving Cancer Research Center, Department of Medicine, Columbia University Medical Center, New York, New York 10032, USA
    Gastroenterology 140:879-91. 2011
    ..Although hormones have been associated with cancer risk, the mechanisms have not been determined. The peptide hormone gastrin exerts a suppressive effect on antral gastric carcinogenesis...
  3. pmc Induction of follistatin precedes gastric transformation in gastrin deficient mice
    Weiqun Kang
    Department of Internal Medicine, University of Michigan, 109 Zina Pitcher Place, BSRB 2051, Ann Arbor, MI 48109 2200, USA
    Biochem Biophys Res Commun 376:573-7. 2008
    We previously showed that antral gastric tumors develop in gastrin-deficient (Gas(-/-)) mice. Therefore Gas(-/-) mice were studied sequentially over 12 months to identify molecular mechanisms underlying gastric transformation...
  4. ncbi Lessons from genetically engineered animal models. I. Physiological studies with gastrin in transgenic mice
    T C Wang
    Gastrointestinal Unit and Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Am J Physiol 277:G6-11. 1999
    ..This themes article highlights recent progress in our understanding of the biology of gastrin through studies in genetically modified mice...
  5. ncbi Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation
    Yana Zavros
    Department of Internal Medicine Gastroenterology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:33265-74. 2007
    ..Moreover parietal cell atrophy, a known pre-neoplastic lesion, correlates with loss of Shh processing...
  6. ncbi Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma
    Yana Zavros
    Department of Gastroenterology, University of Michigan, Ann Arbor, MI 48109 0650, USA
    Oncogene 24:2354-66. 2005
    ..Moreover, neoplastic transformation of the antral gastric mucosa does not require gastrin...
  7. ncbi Interferon gamma induction of gastric mucous neck cell hypertrophy
    Weiqun Kang
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Lab Invest 85:702-15. 2005
    ....
  8. ncbi Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer
    T C Wang
    Gastrointestinal Unit and Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Gastroenterology 118:36-47. 2000
    ..Hypergastrinemia occurs frequently in association with acid suppression and Helicobacter infection, but its role in the progression to gastric atrophy and gastric cancer has not been well defined...
  9. ncbi Gastrin stimulates the growth of gastric pit cell precursors by inducing its own receptors
    Toshio Nakajima
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    Am J Physiol Gastrointest Liver Physiol 282:G359-66. 2002
    ..Thus these findings suggest that gastrin directly stimulates the growth of the pit cell lineage by inducing its own receptor in pit cell precursors...
  10. pmc Gastrin is an essential cofactor for helicobacter-associated gastric corpus carcinogenesis in C57BL/6 mice
    Shigeo Takaishi
    Division of Digestive and Liver Disease, Department of Medicine, Columbia University Medical Center, New York, New York, USA
    Am J Pathol 175:365-75. 2009
    ..However, gastrin-deficient (GAS-KO) mice on a mixed C57BL/6/129Sv genetic background maintained in conventional housing were reported to develop ..
  11. ncbi Impaired gastric acid secretion in gastrin-deficient mice
    L Friis-Hansen
    Department of Physiology, University of Michigan, Ann Arbor 48109, USA
    Am J Physiol 274:G561-8. 1998
    ..The results show that gastrin is critically important for the function of the acid secretory system...
  12. pmc Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia
    Milena Saqui-Salces
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 7:e48039. 2012
    Chronic inflammation in the stomach can lead to gastric cancer. We previously reported that gastrin-deficient (Gast⁻/⁻) mice develop bacterial overgrowth, inflammatory infiltrate, increased Il-1β expression, antral hyperplasia and ..
  13. pmc Arx is required for normal enteroendocrine cell development in mice and humans
    Aiping Du
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, USA
    Dev Biol 365:175-88. 2012
    ..Taken together, our findings uncover a novel and conserved role of Arx in mammalian endocrine cell development and provide a potential cause for the chronic diarrhea seen in both humans and mice carrying Arx mutations...
  14. ncbi Insulin-promoter-factor 1 is required for pancreas development in mice
    J Jonsson
    Department of Microbiology, University of Umea, Sweden
    Nature 371:606-9. 1994
    ..These findings show that IPF1 is needed for the formation of the pancreas and suggest that it acts to determine the fate of common pancreatic precursor cells and/or to regulate their propagation...
  15. ncbi Transgenic insulin released from G cells preferentially signals in the liver
    Yu Chun Lu
    Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine at UCLA and CURE Digestive Diseases Research Center, Los Angeles, CA 90095, USA
    Biochem Biophys Res Commun 355:23-7. 2007
    ..G-InsKi mice provide a novel animal model for elucidating direct effects of insulin on liver functions...
  16. pmc Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion
    Sara Edfalk
    Umeå Center for Molecular Medicine, University of Umea, Umea, Sweden
    Diabetes 57:2280-7. 2008
    ..Here, we addressed whether 1) Gpr40 is expressed in the intestine and 2) Ipf1/Pdx1 function is required for Gpr40 expression...
  17. doi Mash1 is required for neuroendocrine cell development in the glandular stomach
    Hiroshi Kokubu
    Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Genes Cells 13:41-51. 2008
    ....
  18. ncbi Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors
    Julie Pannequin
    CNRS UMR5203, Montpellier, France
    Gastroenterology 133:1554-68. 2007
    ....
  19. ncbi Achlorhydria is associated with gastric microbial overgrowth and development of cancer: lessons learned from the gastrin knockout mouse
    L Friis-Hansen
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
    Scand J Clin Lab Invest 66:607-21. 2006
    ..Study of these mice helps our understanding of how dysregulation of gastrin secretion may be implicated in human disease...
  20. ncbi Gastrin increases murine intestinal crypt regeneration following injury
    Penelope D Ottewell
    Division of Gastroenterology, University of Liverpool, Liverpool, UK
    Gastroenterology 130:1169-80. 2006
    ..We therefore investigated the effects of gastrin on intestinal regeneration following a range of stimuli...
  21. ncbi Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation
    Vinciane Vanhorenbeeck
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Christian de Duve Institute of Cellular Pathology, 75 Avenue Hippocrate, B 1200 Brussels, Belgium
    Dev Biol 305:685-94. 2007
    ..In conclusion, our data reveal partially redundant roles for HNF-6 and OC-2 in developing pancreas and identify new markers for antero-posterior patterning of the gut and for enteroendocrine differentiation...
  22. pmc Circulating gastrin is increased in hemochromatosis
    Kelly A Smith
    University of Melbourne Department of Surgery, Austin Health, Level 8, Lance Townsend Building, Studley Road, Heidelberg, VIC 3084, Australia
    FEBS Lett 580:6195-8. 2006
    ..The discovery of a relationship between iron status and circulating gastrin concentrations opens a new perspective on the mechanisms of iron homeostasis...
  23. ncbi Gastrin-induced apoptosis contributes to carcinogenesis in the stomach
    Guanglin Cui
    Division of Gastroenterology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Lab Invest 86:1037-51. 2006
    Hypergastrinemia in INS-GAS mice leads to accelerated carcinogenesis of the stomach, but the mechanisms have not been well defined...
  24. ncbi Gastrin regulates the TFF2 promoter through gastrin-responsive cis-acting elements and multiple signaling pathways
    Shuiping Tu
    Division of Digestive and Liver Diseases, Dept of Medicine, College of Physicians and Surgeons, Columbia Univ, 1130 St Nicholas Ave, Rm 925, 9th Fl, New York, NY 10032, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1726-37. 2007
    ..TFF2 protein expression in the gastric fundus was elevated in hypergastrinemic (INS-GAS) transgenic mice and reduced in gastrin-deficient mice...
  25. ncbi Significant increase in the aggressive behavior of transgenic mice overexpressing peripheral progastrin peptides: associated changes in CCK2 and serotonin receptors in the CNS
    Qian Li
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77555 0431, USA
    Neuropsychopharmacology 32:1813-21. 2007
    ..Our results suggest that an upregulation of the CCK response system and 5-HT(1A)R in the hypothalamus of Tg/Tg mice may mediate the alterations in the observed behaviors of these mice...
  26. doi Impairment of gastric acid secretion and increase of embryonic lethality in Foxq1-deficient mice
    W Goering
    Institute of Human Genetics, University of Gottingen, Gottingen, Germany
    Cytogenet Genome Res 121:88-95. 2008
    ..Ultrastructural analysis suggests that the gastric acid secretion defect in Foxq1-deficient mice might be due to impairment in the fusion of cytoplasmic tubulovesicles to the apical membrane of secretory canaliculi...
  27. pmc Gastrin-deficient mice have disturbed hematopoiesis in response to iron deficiency
    Suzana Kovac
    University of Melbourne Department of Surgery, Austin Health, Heidelberg, Victoria 3084, Australia
    Endocrinology 152:3062-73. 2011
    ..Here we report the effect of long-term dietary iron modification on gastrin-deficient (Gas(-/-)) and hypergastrinemic cholecystokinin receptor 2-deficient (Cck2r(-/-)) mice, both of which have reduced basal ..
  28. doi Altered gene expression and spongiotrophoblast differentiation in placenta from a mouse model of diabetes in pregnancy
    J M Salbaum
    Laboratory of Regulation of Gene Expression, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Diabetologia 54:1909-20. 2011
    ..g. metabolic syndrome and hypertension. We hypothesised that adverse outcomes from diabetic pregnancies may be linked to compromised placental function, and sought to identify cellular and molecular abnormalities in diabetic placenta...
  29. pmc Regulation of mouse stomach development and Barx1 expression by specific microRNAs
    Byeong Moo Kim
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA
    Development 138:1081-6. 2011
    ..These results indicate that miRNAs are required for proper digestive tract organogenesis and that miR-7a and miR-203 control expression of the stomach homeotic regulator Barx1...
  30. pmc In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice
    Shigeo Takaishi
    Division of Digestive and Liver Disease, Dept of Medicine, Columbia Univ Medical Center, 1130 St Nicholas Ave, ICRC 923, New York, NY, USA
    Am J Physiol Gastrointest Liver Physiol 300:G334-44. 2011
    ..This transgenic mouse provides a useful tool to study the regulation of mouse gastrin gene in vivo, thus contributing to our understanding of the mechanisms involved in transcriptional control of the gastrin gene...
  31. doi Cholecystokinin (CCK)-expressing neurons in the suprachiasmatic nucleus: innervation, light responsiveness and entrainment in CCK-deficient mice
    Jens Hannibal
    Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
    Eur J Neurosci 32:1006-17. 2010
    ....
  32. pmc Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival
    Georg Mellitzer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM U964, CNRS UMR 7104, Universite de Strasbourg, Illkirch, France
    J Clin Invest 120:1708-21. 2010
    ..Our data help unravel the role of enteroendocrine cells and hormones in lipid absorption and maintenance of the intestinal epithelium...
  33. ncbi Immunocytochemical detection of orexin A in endocrine cells of the developing mouse gut
    María J Sánchez de Miguel
    Department of Histology and Pathology, University of Navarra, Pamplona, Spain
    J Histochem Cytochem 50:63-9. 2002
    ..These findings suggest that orexin A may be relevant in the growth and maturation of the gastrointestinal tract during intrauterine life...
  34. pmc Functional cross-talk between beta-catenin and NFkappaB signaling pathways in colonic crypts of mice in response to progastrin
    Shahid Umar
    Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 284:22274-84. 2009
    ..Our studies suggest a novel possibility that activation of beta-catenin, downstream to the IKKalpha,beta/NFkappaB pathway, may be integral to the hyperproliferative effects of progastrin on proximal colonic crypts...
  35. pmc Growth of human pancreatic cancer is inhibited by down-regulation of gastrin gene expression
    Gail L Matters
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, PA 17011, USA
    Pancreas 38:e151-61. 2009
    ..This study evaluated the effects of gastrin messenger RNA (mRNA) down-regulation on growth of human pancreatic cancer...
  36. pmc Altered gastric chief cell lineage differentiation in histamine-deficient mice
    Koji Nozaki
    Vanderbilt Univ Sch of Medicine, Dept of Surgery, Epithelial Biology Center, MRBIV Bm 10435G, 2213 Garland Ave, Nashville, TN 37232, USA
    Am J Physiol Gastrointest Liver Physiol 296:G1211-20. 2009
    ..Nevertheless, histamine is not required for emergence of SPEM following acute oxyntic atrophy...
  37. doi Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors
    Yu Cheng Wang
    UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA
    Endocr Relat Cancer 16:267-79. 2009
    ..2 functions in immature endocrine cells to control NE differentiation in normal intestine and is expressed in most NE tumors of the gut, and is therefore a novel target of diagnosis for patients with gastrointestinal NE tumors...
  38. pmc Hip1r is expressed in gastric parietal cells and is required for tubulovesicle formation and cell survival in mice
    Renu N Jain
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    J Clin Invest 118:2459-70. 2008
    ..Taken together, these studies demonstrate that Hip1r plays a significant role in gastric physiology, mucosal architecture, and secretory membrane dynamics in parietal cells...
  39. pmc Interrelationships between circulating gastrin and iron status in mice and humans
    Suzana Kovac
    Univ of Melbourne Dept of Surgery, Austin Health, Studley Rd, Heidelberg, Victoria 3084, Australia
    Am J Physiol Gastrointest Liver Physiol 295:G855-61. 2008
    ..004) with an increased transferrin saturation. Our data indicate that, in juvenile animals when iron demand is high, circulating gastrin concentrations may alter iron status by a CCK2R-independent mechanism...
  40. pmc Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells
    Michael P Verzi
    Dana Farber Cancer Institute and Department of Medicine, Boston, Massachusetts, USA
    Gastroenterology 135:591-600. 2008
    ..We identified stomach-restricted expression of the forkhead transcription factor FOXQ1...
  41. ncbi Attenuation of peroxisome proliferator-activated receptor gamma (PPARgamma) mediates gastrin-stimulated colorectal cancer cell proliferation
    Albert J Chang
    Section of Gastroenterology, Boston University School of Medicine and Boston Medical Center, 650 Albany Street, Boston, MA 02118, USA
    J Biol Chem 281:14700-10. 2006
    ....
  42. ncbi Development of a deer mouse whole-genome radiation hybrid panel and comparative mapping of Mus chromosome 11 loci
    Clifton M Ramsdell
    Peromyscus Genetic Stock Center, Department of Biological Sciences, University of South Carolina, 700 Sumter Street, Columbia, South Carolina 29208, USA
    Mamm Genome 17:37-48. 2006
    ..Furthermore, this separate linkage group is likely to reside in a chromosomal region of inversion polymorphism between P. maniculatus and P. polionotus...
  43. ncbi Cloning and analysis of Nkx6.3 during CNS and gastrointestinal development
    Tomas Alanentalo
    Umeå Centre for Molecular Medicine, UCMM, Umea University, S 901 87 Umea, Sweden
    Gene Expr Patterns 6:162-70. 2006
    ..2 both in the CNS and in the gut. Transient Nkx6.2 expression was also detected in the developing pancreas. However, analysis of Nkx6.2(-/-) mice did not display any obvious aberrations of pancreatic or stomach development...
  44. ncbi Chronic Helicobacter pylori infection results in gastric hypoacidity and hypergastrinemia in wild-type mice but vagally induced hypersecretion in gastrin-deficient mice
    Chun Mei Zhao
    Departments of Cancer Research and Molecular Medicine and Laboratory Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Regul Pept 115:161-70. 2003
    ..pylori infection results to impaired parietal-cell function (acid hyposecretion), hypergastrinemia and hyperplasia of ECL cells in wild-type mice but leads to vagally induced hypersecretion in gastrin-deficient mice...
  45. ncbi Enhanced calcium signaling and acid secretion in parietal cells isolated from gastrin-deficient mice
    Karen L Hinkle
    Department of Physiology, University of Michigan, Ann Arbor 48109 0622, USA
    Am J Physiol Gastrointest Liver Physiol 284:G145-53. 2003
    ..Parietal cells were found to be significantly smaller in the mutant cell preparations, suggesting that gastrin stimulation modulates parietal cell morphology...
  46. pmc Potential role of endocrine gastrin in the colonic adenoma carcinoma sequence
    S A Watson
    Academic Unit of Cancer Studies, University of Nottingham, Nottingham, NG7 2UH, UK
    Br J Cancer 87:567-73. 2002
    ..The effect of hypergastrinaemia on tumour growth was reversed by use of antiserum directed against the CCK-2 receptor. Hyper-gastrinaemia may promote proliferation of human colonic adenomas that express CCK-2 receptor isoforms...
  47. ncbi Gastrin interferes with the differentiation of gastric pit cells and parietal cells
    T Nakajima
    Division of Gastroenterology and Hepatology, Kyoto University, Graduate School of Medicine, Sakyo ku 606 8507, Japan
    Aliment Pharmacol Ther 16:3-9. 2002
    ..Gastrin is known to have stimulatory effects on gastric mucosa; however, long-term effect of gastrin stimulation is not well known...
  48. ncbi Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
    Q Yang
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Science 294:2155-8. 2001
    ..The continuous rapid renewal of these cells makes the intestinal epithelium a model system for the study of stem cell regeneration and lineage commitment...
  49. pmc Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11
    P Liu
    Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genetics 150:1155-68. 1998
    ..A duplication corresponding to one of these two deficiencies was able to rescue its haplolethality...
  50. ncbi Disturbed progastrin processing in carboxypeptidase E-deficient fat mice
    K A Lacourse
    Department of Physiology, University of Michigan, Ann Arbor 48109 0622, USA
    FEBS Lett 416:45-50. 1997
    ..Hence, the increase of glycine-extended gastrin in combination with normal levels of carboxyamidated gastrin suggests that G-cells may have another biosynthetic pathway for gastrin...
  51. pmc G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo
    A Nagata
    Department of Medicine, Kobe University School of Medicine, Japan
    Proc Natl Acad Sci U S A 93:11825-30. 1996
    ..These results clearly demonstrated that the G protein-coupled CCK-B/gastrin receptor is essential for the physiological as well as pathological proliferation of gastric mucosal cells in vivo...
  52. pmc Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells
    T C Wang
    Department of Medicine, Massachusetts General Hospital, Boston 02114
    J Clin Invest 92:1349-56. 1993
    ..This transgenic study suggests that islet neogenesis can be reactivated in the ductular epithelium of the adult pancreas by local expression of two growth factors, gastrin and TGF alpha...
  53. ncbi Sequences responsible for transcription termination of the mouse gastrin gene
    M J Noh
    Department of Life Science, Korea Advanced Institute of Science and Technology, Taejon
    Biochem Mol Biol Int 35:1205-13. 1995
    ....
  54. ncbi Gastrin regulates the heparin-binding epidermal-like growth factor promoter via a PKC/EGFR-dependent mechanism
    Natalie F Sinclair
    University of Massachusetts Memorial Medical Center, Division of Digestive Diseases and Nutrition, Worcester, 01655, USA
    Am J Physiol Gastrointest Liver Physiol 286:G992-9. 2004
    ..The cis-acting element mediating gastrin responsiveness was mapped to the -69 to -58 region of the HB-EGF promoter. Gastrin stimulation was PKC dependent and at least partially mediated by activation of the EGF receptor...
  55. ncbi Acidic duodenal pH alters gene expression in the cystic fibrosis mouse pancreas
    Simran Kaur
    Dept of Anatomy and Cell Biology, Univ of Kansas School of Medicine, Kansas City, KS 66160, USA
    Am J Physiol Gastrointest Liver Physiol 287:G480-90. 2004
    ..It is concluded that the acidic duodenal pH in CF contributes to the stress on the exocrine pancreas and that normalizing duodenal pH reduces this stress...
  56. ncbi Growth factors associated with gastric mucosal hypertrophy in autoimmune gastritis
    Teo V Franic
    The Russell Grimwade School of Biochemistry and Molecular Biology, The Univ of Melbourne, Melbourne, VIC 3010, Australia
    Am J Physiol Gastrointest Liver Physiol 287:G910-8. 2004
    ..These findings are likely to be of relevance to other gastric inflammatory conditions...
  57. ncbi Gene expression profiling of gastrin target genes in parietal cells
    Renu N Jain
    Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan 48109 0622, USA
    Physiol Genomics 24:124-32. 2006
    ..Hence, the aim of this study was to evaluate changes in the acid-secreting parietal cell in gastrin-deficient (GAS-KO) mice...
  58. ncbi Involvement of cyclooxygenase-2 in gastric mucosal hypertrophy in gastrin transgenic mice
    Naoki Kanda
    Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Shogoin Kawara cho 54, Sakyo ku, Kyoto 606 8507, Japan
    Am J Physiol Gastrointest Liver Physiol 290:G519-27. 2006
    ..Hypergastrinemic mice [mice with mutated gastrin under the control of the beta-actin promoter (ACT-GAS mice)] received the COX-2 inhibitor celecoxib (0, 200, or 500 mg/kg of diet) from 5 wk of age and were killed at 16 ..
  59. pmc Direct regulation of intestinal fate by Notch
    Ben Z Stanger
    Howard Hughes Medical Institute and Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 102:12443-8. 2005
    ..In the embryo, Notch activation perturbs morphogenesis, possibly through effects on stem or progenitor cells...
  60. ncbi Reduced ghrelin, islet amyloid polypeptide, and peptide YY expression in the stomach of gastrin-cholecystokinin knockout mice
    Lennart Friis-Hansen
    Department of Clinical Biochemistry, KB 3011, Rigshospitalet, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Endocrinology 146:4464-71. 2005
    ..Both gastrin and combined gastrin-CCK deficiency reduced the gastric IAPP and PYY expression...
  61. ncbi Molecular cloning and sequencing of the murine gastrin gene
    T J Koh
    Gastrointestinal Unit, Massachusetts General Hospital, Boston 02114, USA
    Biochem Biophys Res Commun 216:34-41. 1995
    ..Transfection studies demonstrated that the murine gastrin gene expression is stimulated by epidermal growth factor to the same extent as the human gastrin gene...
  62. ncbi Reciprocal changes in trefoil 1 and 2 expression in stomachs of mice with gastric unit hypertrophy and inflammation
    T V Franic
    Department of Medicine, The University of Melbourne, Western Hospital, Melbourne, VIC 3011, Australia
    J Pathol 207:43-52. 2005
    ..Additionally, a clear role for inflammation was established involving both polymorphonuclear and mononuclear cells in these models, and a link was found between mucosal hypertrophy and increased interleukin-11 (IL-11) expression...
  63. ncbi COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo
    P D Ottewell
    Deptartment of Medicine, 5th Fl UCD Bldg, Daulby St, Liverpool L69 3BX, UK
    Am J Physiol Gastrointest Liver Physiol 288:G541-9. 2005
    ....
  64. ncbi Abdominal obesity, insulin resistance, and colon carcinogenesis are increased in mutant mice lacking gastrin gene expression
    Stephanie L Cowey
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas 77555 1043, USA
    Cancer 103:2643-53. 2005
    The authors recently reported that gastrin gene knockout (GAS-KO) mice had an increased risk for colon carcinogenesis in response to azoxymethane (AOM) compared with their wild type (WT) littermates...
  65. pmc Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation
    T J Koh
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Invest 103:1119-26. 1999
    ..To our knowledge, these studies demonstrate for the first time that G-Gly's contribute to colonic mucosal proliferation in vivo...
  66. ncbi Chromosome engineering in mice
    R Ramirez-Solis
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 378:720-4. 1995
    ..The availability of mice with defined regions of segmental haploidy will allow their use in genetic screens and enable accurate models of human 'chromosomal' diseases to be generated...
  67. ncbi Reduced effects of amphetamine on prepulse inhibition of startle in gastrin-deficient mice
    Maarten van den Buuse
    Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, VIC 3052, Australia
    Neurosci Lett 373:237-42. 2005
    ..These data suggest a role of gastrin in the brain in modulating dopamine release in areas involved in PPI...
  68. ncbi Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression
    Daniel F Boyer
    Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175, USA
    Dev Biol 298:616-31. 2006
    ..These results reveal a role for distal cis-regulatory elements in achieving the correct level of extra-pancreatic Pdx1 expression, which is necessary for the production of duodenal GIP cells and stomach gastrin cells...
  69. ncbi Transcriptional profiling of gastrin-regulated genes in mouse stomach
    Renu N Jain
    Department of Molecular and Integrative Physiology, The University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Physiol Genomics 29:1-12. 2007
    ..Accordingly, gastrin-deficient (GAS-KO) mice have a severe impairment in acid secretion...
  70. ncbi Nested chromosomal deletions induced with retroviral vectors in mice
    H Su
    Program in Developmental Biology, Department of Molecular Genetics, Baylor College of Medicine, Houston, Texas, USA
    Nat Genet 24:92-5. 2000
    ..Our approach can be extended to any region of the mouse genome...
  71. pmc Gastrin is a target of the beta-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis
    T J Koh
    Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Invest 106:533-9. 2000
    ..The identification of gastrin as a functionally relevant downstream target of the beta-catenin signaling pathway provides a new target for therapeutic modalities in the treatment of colorectal cancer...
  72. ncbi The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling
    Byeong Moo Kim
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Cell 8:611-22. 2005
    ..These results define a transcriptional and signaling pathway of inductive cell interactions in vertebrate organogenesis...
  73. ncbi BAC contig from a 3-cM region of mouse chromosome 11 surrounding Brca1
    M Pershouse
    Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Genomics 69:139-42. 2000
    ..The region described is one of the targets of a large effort to create a series of mice with regional deletions on mouse chromosome 11 (33-80 cM) that can subsequently be subjected to further mutagenesis...
  74. ncbi Lessons from the gastrin and gastrin receptor knockout mice
    L Friis-Hansen
    Dept of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark
    Scand J Clin Lab Invest Suppl 234:41-6. 2001
    ....
  75. ncbi Regulation of parietal cell migration by gastrin in the mouse
    C M Kirton
    Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 283:G787-93. 2002
    ..10-30 days after BrdU injection in mice in which the gastrin gene had been deleted by homologous recombination (Gas-KO) and wild-type (C57BL/6) mice. The time course of labeling was similar in the two groups...

Research Grants43

  1. Stem Cells and Gastric Cancer
    TIMOTHY CRAGIN WANG; Fiscal Year: 2010
    ....
  2. The Function and Regulation of Trefoil Factor Family 2 (TFF2)
    TIMOTHY CRAGIN WANG; Fiscal Year: 2010
    ..TFF2 is suppressed by the tumor suppressor gene p53, and we will also attempt to show that it is an important downstream target of this tumor suppressor through its activity in regulating the immune system. ..
  3. Stem Cells and Gastric Cancer
    Timothy Wang; Fiscal Year: 2007
    ....
  4. Role of Inflamation in Mouse Models of Gastric Cancer
    Timothy Wang; Fiscal Year: 2007
    ..We will test the hypothesis that inhibition of NF-kB in epithelial cell will promote apoptosis and BMDC engraftment. ..
  5. REGULATION OF HISTIDINE DECARBOXYLASE
    Timothy Wang; Fiscal Year: 2007
    ..Overall, these studies will provide new insights into the regulation of HDC gene expression and enzymatic activity, and its function in the gastric mucosa. ..
  6. FUNCTION AND REGULATION OF GASTRIN
    Timothy Wang; Fiscal Year: 2007
    ..Overall, these studies will attempt to define the role of progastrin-derived peptides in stem cell regulation and in bridging genetic pathways in colorectal cancer. ..
  7. Role of Inflamation in Mouse Models of Gastric Cancer
    TIMOTHY CRAGIN WANG; Fiscal Year: 2010
    ..We will test the hypothesis that inhibition of NF-kB in epithelial cell will promote apoptosis and BMDC engraftment. ..
  8. Stem Cells and Gastric Cancer
    Timothy Wang; Fiscal Year: 2009
    ....
  9. Role of Inflamation in Mouse Models of Gastric Cancer
    Timothy Wang; Fiscal Year: 2009
    ..We will test the hypothesis that inhibition of NF-kB in epithelial cell will promote apoptosis and BMDC engraftment. ..
  10. 14th International Symposium on Regulatory Peptides
    Timothy Wang; Fiscal Year: 2002
    ..abstract_text> ..
  11. REGULATION OF HISTIDINE DECARBOXYLASE
    Timothy Wang; Fiscal Year: 2002
    ..elements mediating gastrin responsiveness in the HDC gene have been identified as two novel cis-acting elements (GAS-RE1 and GAS-RE2) which are located in tandem downstream of the transcriptional start site, and bind to 52 kD and 35 ..
  12. FUNCTION AND REGULATION OF GASTRIN
    Timothy Wang; Fiscal Year: 2000
    ..b) Elucidate whether over-expression of incompletely processed forms of gastrin stimulate colonic proliferation and predispose mice to colonic carcinoma. c) Evaluate the role of gastrin in gastrointestinal tract development. ..
  13. FUNCTION & REGULATION OF SPASMOLYTIC POLYPEPTIDE/TFF2
    Timothy Wang; Fiscal Year: 2005
    ..felis models. Overall, these studies will utilize gastric cancer models to explore the function and regulation of SP, and may provide further insight into the biology of mucous neck cells. ..
  14. Mouse Models of Gastric Cancer
    Timothy Wang; Fiscal Year: 2005
    ..Our group has developed a hypergastrinemic transgenic (insulin-gastrin or INS-GAS) mouse model that shows progression over time to gastric atrophy, intestinal metaplasia, dysplasia and gastric ..