Gapdh

Summary

Gene Symbol: Gapdh
Description: glyceraldehyde-3-phosphate dehydrogenase
Alias: Gapd, glyceraldehyde-3-phosphate dehydrogenase, peptidyl-cysteine S-nitrosylase GAPDH
Species: mouse
Products:     Gapdh

Top Publications

  1. Nakajima H, Amano W, Kubo T, Fukuhara A, Ihara H, Azuma Y, et al. Glyceraldehyde-3-phosphate dehydrogenase aggregate formation participates in oxidative stress-induced cell death. J Biol Chem. 2009;284:34331-41 pubmed publisher
    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)(2) is a classic glycolytic enzyme that also mediates cell death by its nuclear translocation under oxidative stress...
  2. Sen N, Hara M, Ahmad A, Cascio M, Kamiya A, Ehmsen J, et al. GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron. 2009;63:81-91 pubmed publisher
    ..a cell death cascade whereby cellular stressors activate nitric oxide formation leading to S-nitrosylation of GAPDH that binds to Siah and translocates to the nucleus...
  3. Sen N, Hara M, Kornberg M, Cascio M, Bae B, Shahani N, et al. Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nat Cell Biol. 2008;10:866-73 pubmed publisher
    Besides its role in glycolysis, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) initiates a cell death cascade...
  4. Kornberg M, Sen N, Hara M, Juluri K, Nguyen J, Snowman A, et al. GAPDH mediates nitrosylation of nuclear proteins. Nat Cell Biol. 2010;12:1094-100 pubmed publisher
    ..Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is physiologically nitrosylated at its Cys 150 residue...
  5. Hara M, Agrawal N, Kim S, Cascio M, Fujimuro M, Ozeki Y, et al. S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol. 2005;7:665-74 pubmed
    Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) influences cytotoxicity, translocating to the nucleus during apoptosis...
  6. Rodriguez Pascual F, Redondo Horcajo M, Magán Marchal N, Lagares D, Martínez Ruiz A, Kleinert H, et al. Glyceraldehyde-3-phosphate dehydrogenase regulates endothelin-1 expression by a novel, redox-sensitive mechanism involving mRNA stability. Mol Cell Biol. 2008;28:7139-55 pubmed publisher
    ..We now identify glyceraldehyde-3'-phosphate dehydrogenase (GAPDH) as a protein which binds to the AREs and is responsible for the destabilization of the mRNA...
  7. Garcia Meunier P, Etienne Julan M, Fort P, Piechaczyk M, Bonhomme F. Concerted evolution in the GAPDH family of retrotransposed pseudogenes. Mamm Genome. 1993;4:695-703 pubmed
    In murine rodents the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) multigene family includes more than 300 retroprocessed pseudogenes. Its single functional gene encodes GAPDH, an enzyme of glycolysis...
  8. Shaw L, Johnson P, Kimber S. Gene expression profiling of the developing mouse kidney and embryo. In Vitro Cell Dev Biol Anim. 2010;46:155-65 pubmed publisher
    ..Use of a combination of highly expressed and negative markers may aid in the identification and removal of non-renal cells from heterogeneous populations of differentiating stem cells. ..
  9. Pearce L, Sommer E, Sakamoto K, Wullschleger S, Alessi D. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. Biochem J. 2011;436:169-79 pubmed publisher
    ..Taken together, these results suggest that Protor-1 may play a role in enabling mTORC2 to efficiently activate SGK1, at least in the kidney. ..

More Information

Publications95

  1. Hatle K, Gummadidala P, Navasa N, Bernardo E, Dodge J, Silverstrim B, et al. MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations. Mol Cell Biol. 2013;33:2302-14 pubmed publisher
    ..Impaired expression or loss of MCJ expression may therefore result in a "rapid" metabolism that mitigates the consequences of metabolic disorders. ..
  2. Jones S, Roe A, Donehower L, Bradley A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature. 1995;378:206-8 pubmed
    ..Mice deficient for Mdm2 die early in development. In contrast, mice deficient for both Mdm2 and p53 develop normally and are viable. These results suggest that a critical role of Mdm2 in development is the regulation of p53 function. ..
  3. Schmitz H, Bereiter Hahn J. Glyceraldehyde-3-phosphate dehydrogenase associates with actin filaments in serum deprived NIH 3T3 cells only. Cell Biol Int. 2002;26:155-64 pubmed
    The in vitro interaction between the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and cytoskeletal elements is well documented...
  4. Ito M, Yuan C, Okano H, Darnell R, Roeder R. Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol Cell. 2000;5:683-93 pubmed
    ..These results indicate that TRAP220 is essential for a wide range of physiological processes but also that it has gene- and activator-selective functions. ..
  5. Bond S, Howlett K, Kowalski G, Mason S, Connor T, Cooper A, et al. Lysine post-translational modification of glyceraldehyde-3-phosphate dehydrogenase regulates hepatic and systemic metabolism. FASEB J. 2017;31:2592-2602 pubmed publisher
    ..organisms has found that reversible post-translational modification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH), particularly acetylation, contributes to the reciprocal regulation of glycolysis/gluconeogenesis...
  6. Boda E, Pini A, Hoxha E, Parolisi R, Tempia F. Selection of reference genes for quantitative real-time RT-PCR studies in mouse brain. J Mol Neurosci. 2009;37:238-53 pubmed publisher
    ..The aim of this work was to verify the suitability of some very common housekeeping genes (such as Gapdh, 18s, and B2m) and of some relatively new control genes (such as Pgk1, Tfrc, and Gusb) during mouse brain ..
  7. Mustafa A, Gadalla M, Sen N, Kim S, Mu W, Gazi S, et al. H2S signals through protein S-sulfhydration. Sci Signal. 2009;2:ra72 pubmed publisher
    ..About 10 to 25% of many liver proteins, including actin, tubulin, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), are sulfhydrated under physiological conditions...
  8. Ruiz J, Robertson E. The expression of the receptor-protein tyrosine kinase gene, eck, is highly restricted during early mouse development. Mech Dev. 1994;46:87-100 pubmed
    ..These data suggest that eck may be involved in cell-cell interactions guiding early hindbrain development. ..
  9. Meng Y, Liu X, Ma X, Shen Y, Fan L, Leng J, et al. The protein profile of mouse mature cumulus-oocyte complex. Biochim Biophys Acta. 2007;1774:1477-90 pubmed
    ..These data provide valuable information for future studies to identify proteins involved in ovarian follicular development and related reproductive abnormalities. ..
  10. Vock C, Yildirim A, Wagner C, Schlick S, Lunding L, Lee C, et al. Distal airways are protected from goblet cell metaplasia by diminished expression of IL-13 signalling components. Clin Exp Allergy. 2015;45:1447-58 pubmed publisher
    ..This might represent a protective strategy to prevent mucus plugging of distal airways and thus impaired ventilation of attached alveoli. ..
  11. Basudhar D, Bharadwaj G, Cheng R, Jain S, Shi S, Heinecke J, et al. Synthesis and chemical and biological comparison of nitroxyl- and nitric oxide-releasing diazeniumdiolate-based aspirin derivatives. J Med Chem. 2013;56:7804-20 pubmed publisher
    ..Together, these anti-inflammatory, antineoplasic, and contractile properties suggest the potential of HNO-NSAIDs in the treatment of inflammation, cancer, or heart failure. ..
  12. Wenger R, Rochelle J, Seldin M, Kohler G, Nielsen P. The heat stable antigen (mouse CD24) gene is differentially regulated but has a housekeeping promoter. J Biol Chem. 1993;268:23345-52 pubmed
    ..Large fragments from the flanking region of the Cd24a promoter did not influence the ubiquitous nature of this promoter. Finally, we mapped the Cd24a, Cd24b, and Cd24c genes to mouse chromosomes 10, 8, and 14 respectively. ..
  13. Cueille N, Blanc C, Riederer I, Riederer B. Microtubule-associated protein 1B binds glyceraldehyde-3-phosphate dehydrogenase. J Proteome Res. 2007;6:2640-7 pubmed
    ..Among these proteins were glyceraldehyde-3-phosphate dehydrogenase (GAPDH), heat shock protein 8, dihydropyrimidinase related proteins 2 and 3, protein-L-isoaspartate O-methyltransferase, ..
  14. Kondoh H, Lleonart M, Gil J, Wang J, Degan P, Peters G, et al. Glycolytic enzymes can modulate cellular life span. Cancer Res. 2005;65:177-85 pubmed
    ..Because wild-type p53 down-regulates PGM, mutation of p53 can facilitate immortalization via effects on PGM levels and glycolysis. ..
  15. Mathiyalagan P, Okabe J, Chang L, Su Y, Du X, El Osta A. The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart. Nucleic Acids Res. 2014;42:790-803 pubmed publisher
    ..These studies provide a framework for MHC expression and regulation of genes implicated in pathological remodeling of ventricular hypertrophy. ..
  16. Chauvin T, Xie F, Liu T, Nicora C, Yang F, Camp D, et al. A systematic analysis of a deep mouse epididymal sperm proteome. Biol Reprod. 2012;87:141 pubmed publisher
    ..This proteome should prove a useful tool for assembly and testing of protein networks important for sperm function. ..
  17. Strutz F, Okada H, Lo C, Danoff T, Carone R, Tomaszewski J, et al. Identification and characterization of a fibroblast marker: FSP1. J Cell Biol. 1995;130:393-405 pubmed
    ..Use of the FSP1 marker, therefore, should further facilitate both the in vivo studies of fibrogenesis and the mapping of cell fate among fibroblasts. ..
  18. Furuichi T, Simon Chazottes D, Fujino I, Yamada N, Hasegawa M, Miyawaki A, et al. Widespread expression of inositol 1,4,5-trisphosphate receptor type 1 gene (Insp3r1) in the mouse central nervous system. Receptors Channels. 1993;1:11-24 pubmed
    ..The chromosomal localization of the gene coding for InsP3R1 was confirmed on chromosome 6 but was found to be genetically independent of the Lurcher (Lc) mutation. ..
  19. Cumming R, Schubert D. Amyloid-beta induces disulfide bonding and aggregation of GAPDH in Alzheimer's disease. FASEB J. 2005;19:2060-2 pubmed
    b>GAPDH is a redox-sensitive glycolytic enzyme that also promotes apoptosis when translocated to the nucleus and associates with aggregate-prone proteins involved in neurodegenerative disorders...
  20. Chakravarti S, Hassell J, Phillips S. Perlecan gene expression precedes laminin gene expression during differentiation of F9 embryonal carcinoma cells. Dev Dyn. 1993;197:107-14 pubmed
    ..Thus, the perlecan and laminin genes appear to be regulated by different mechanisms and their gene products are not made in stoichiometric amounts. ..
  21. Jansen G, Bächner D, Coerwinkel M, Wormskamp N, Hameister H, Wieringa B. Structural organization and developmental expression pattern of the mouse WD-repeat gene DMR-N9 immediately upstream of the myotonic dystrophy locus. Hum Mol Genet. 1995;4:843-52 pubmed
    ..We conclude that the DMR-N9 gene is a candidate for being involved in the manifestation of mental and testicular symptoms in severe cases of DM. ..
  22. Vizard T, O Keeffe G, Gutierrez H, Kos C, Riccardi D, Davies A. Regulation of axonal and dendritic growth by the extracellular calcium-sensing receptor. Nat Neurosci. 2008;11:285-91 pubmed publisher
    ..Our findings reveal a crucial role for CaSR in regulating the growth of neural processes in the peripheral and central nervous systems. ..
  23. Zaid H, Talior Volodarsky I, Antonescu C, Liu Z, Klip A. GAPDH binds GLUT4 reciprocally to hexokinase-II and regulates glucose transport activity. Biochem J. 2009;419:475-84 pubmed publisher
    ..by MS proteins displaying insulin-dependent co-precipitation with Myc-tagged GLUT4 from L6 myotubes, including GAPDH (glyceraldehyde-3-phosphate dehydrogenase) and HKII (hexokinase-II)...
  24. Ikeda Y, Yamaji R, Irie K, Kioka N, Murakami A. Glyceraldehyde-3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stability. Arch Biochem Biophys. 2012;528:141-7 pubmed publisher
    ..We investigated whether glyceraldehyde-3-phosphate dehydrogenase (GAPDH) binds to the AU-rich element (ARE) of COX-2 mRNA for its degradation...
  25. Mariani T, Reed J, Shapiro S. Expression profiling of the developing mouse lung: insights into the establishment of the extracellular matrix. Am J Respir Cell Mol Biol. 2002;26:541-8 pubmed
    ..These data should serve as a resource for the pulmonary research community and assist in deciphering the molecular mechanisms governing normal lung development as well as those involved in aberrant developmental pathology. ..
  26. Chaudhry H, Dashoush N, Tang H, Zhang L, Wang X, Wu E, et al. Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium. J Biol Chem. 2004;279:35858-66 pubmed
    ..These results reveal a previously unrecognized critical role for cyclin A2 in mediating cardiomyocyte mitosis, a role that may significantly impact upon clinical treatment of damaged myocardium. ..
  27. Hanauer A, Mandel J. The glyceraldehyde 3 phosphate dehydrogenase gene family: structure of a human cDNA and of an X chromosome linked pseudogene; amazing complexity of the gene family in mouse. EMBO J. 1984;3:2627-33 pubmed
    ..cDNA library and an X chromosome specific library, we have isolated cDNA clones corresponding to glyceraldehyde 3 phosphate dehydrogenase (GAPD), (whose gene is assigned to chromosome 12), and a DNA fragment from the X chromosome short ..
  28. Lee J, Ward W, Knapp G, Ren H, Vallanat B, Abbott B, et al. Transcriptional ontogeny of the developing liver. BMC Genomics. 2012;13:33 pubmed publisher
    ..Overall, these findings reveal the complexity of gene expression changes during liver development and maturation, and provide a foundation to predict responses to chemical and drug exposure as a function of early life-stages. ..
  29. Takahashi T, Eitzman B, Bossert N, Walmer D, Sparrow K, Flanders K, et al. Transforming growth factors beta 1, beta 2, and beta 3 messenger RNA and protein expression in mouse uterus and vagina during estrogen-induced growth: a comparison to other estrogen-regulated genes. Cell Growth Differ. 1994;5:919-35 pubmed
    ..abstract truncated at 400 words) ..
  30. Lee F, Su P, Xie Y, Wang K, Wan Q, Liu F. Disrupting GluA2-GAPDH Interaction Affects Axon and Dendrite Development. Sci Rep. 2016;6:30458 pubmed publisher
    ..We report here that the interaction between GluA2 and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is necessary for neuron and cortical development...
  31. Bailey C, Hammers D, DeFord J, Dimayuga V, Amaning J, Farrar R, et al. Ishemia-reperfusion enhances GAPDH nitration in aging skeletal muscle. Aging (Albany NY). 2011;3:1003-17 pubmed
    ..Our studies show that glyceraldehyde-3-phosphate dehydrogenase (GAPDH) protein expression is significantly decreased at 3 and 5 days reperfusion in the young mouse muscle and at 1, 3, ..
  32. Nakao M, Sutcliffe J, Beaudet A. Advantages of RT-PCR and denaturing gradient gel electrophoresis for analysis of genomic imprinting: detection of new mouse and human expressed polymorphisms. Hum Mutat. 1996;7:144-8 pubmed
    ..brain, maternal expression of H19 in liver, and biallelic expression of glyceraldehyde 3-phosphate dehydrogenease (Gapd) in liver...
  33. Jella K, Yu L, Yue Q, Friedman D, Duke B, Alli A. Exosomal GAPDH from Proximal Tubule Cells Regulate ENaC Activity. PLoS ONE. 2016;11:e0165763 pubmed publisher
    ..Active GAPDH was identified within exosomes derived from proximal tubule LLC-PK1 cells...
  34. Lyons I, Parsons L, Hartley L, Li R, Andrews J, Robb L, et al. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev. 1995;9:1654-66 pubmed
    ..The data demonstrate that Nkx2-5 is essential for normal heart morphogenesis, myogenesis, and function. Furthermore, this gene is a component of a genetic pathway required for myogenic specialization of the ventricles. ..
  35. Schmitt I, Bächner D, Megow D, Henklein P, Hameister H, Epplen J, et al. Expression of the Huntington disease gene in rodents: cloning the rat homologue and evidence for downregulation in non-neuronal tissues during development. Hum Mol Genet. 1995;4:1173-82 pubmed
    ..In contrast, the expression in non-neuronal tissues is markedly reduced in adult animals and corresponds to the restricted distribution of neuropathologic changes observed in HD patients. ..
  36. Silva L, Cliffe A, Chang L, Knipe D. Role for A-type lamins in herpesviral DNA targeting and heterochromatin modulation. PLoS Pathog. 2008;4:e1000071 pubmed publisher
    ..The nuclear lamina can serve as a molecular scaffold for DNA genomes and the protein complexes that regulate both euchromatin and heterochromatin histone modifications...
  37. Makhina T, Loers G, Schulze C, Ueberle B, Schachner M, Kleene R. Extracellular GAPDH binds to L1 and enhances neurite outgrowth. Mol Cell Neurosci. 2009;41:206-18 pubmed publisher
    We have identified glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a binding partner for the cell adhesion molecule L1...
  38. Jeong Y, Choi H, Shin H, Cui X, Kim N, Gerton G, et al. Optimization of real time RT-PCR methods for the analysis of gene expression in mouse eggs and preimplantation embryos. Mol Reprod Dev. 2005;71:284-9 pubmed
    ..of preimplantation development were isolated and the levels of transcripts encoded by several housekeeping genes (GAPDH, beta-actin, ribosomal protein L7, 16s ribosomal protein, histone H2A...
  39. Chakravarti R, Stuehr D. Thioredoxin-1 regulates cellular heme insertion by controlling S-nitrosation of glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem. 2012;287:16179-86 pubmed publisher
    NO generated by inducible NOS (iNOS) causes buildup of S-nitrosated GAPDH (SNO-GAPDH) in cells, which then inhibits further iNOS maturation by limiting the heme insertion step (Chakravarti, R., Aulak, K. S., Fox, P. L., and Stuehr, D. J...
  40. Shalova I, Cechalova K, Rehakova Z, Dimitrova P, Ognibene E, Caprioli A, et al. Decrease of dehydrogenase activity of cerebral glyceraldehyde-3-phosphate dehydrogenase in different animal models of Alzheimer's disease. Biochim Biophys Acta. 2007;1770:826-32 pubmed
    Recently, a relationship between glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and the beta-amyloid precursor protein (betaAPP) in relationship with the pathogenesis of Alzheimer's disease (AD) has been suggested...
  41. Bruns G, Gerald P. Human glyceraldehyde-3-phosphate dehydrogenase in man-rodent somatic cell hybrids. Science. 1976;192:54-6 pubmed
    The human enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) forms heteropolymers with the rodent enzyme in man-rodent somatic cell hybrids...
  42. Lee S, Kim C, Lee K, Ahn J. S-nitrosylation of B23/nucleophosmin by GAPDH protects cells from the SIAH1-GAPDH death cascade. J Cell Biol. 2012;199:65-76 pubmed publisher
    ..a novel neuroprotective function of B23 through regulation of the SIAH1-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) death cascade...
  43. Kathiresan T, Harvey M, Orchard S, Sakai Y, Sokolowski B. A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea. Mol Cell Proteomics. 2009;8:1972-87 pubmed publisher
    ..The studies described herein provide insights into BK-related functions that include not only cell excitation, but also cell signaling and apoptosis, and involve proteins concerned with Ca(2+) regulation, structure, and hearing loss. ..
  44. Klein S, Morrice D, Sang H, Crittenden L, Burt D. Genetic and physical mapping of the chicken IGF1 gene to chromosome 1 and conservation of synteny with other vertebrate genomes. J Hered. 1996;87:10-4 pubmed
    ..Comparison of physical and genetic linkage maps locates the centromere between the IGF1 and GAPD loci...
  45. Applequist S, Keyna U, Calvin M, Beck Engeser G, Raman C, Jäck H. Sequence of the rabbit glyceraldehyde-3-phosphate dehydrogenase-encoding cDNA. Gene. 1995;163:325-6 pubmed
    Two full-length cDNA clones encoding rabbit glyceraldehyde-3-phosphate dehydrogenase (GAPDH) were isolated from a lambda gt10 rabbit spleen cDNA library and sequenced...
  46. Bultman S, Gebuhr T, Magnuson T. A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development. Genes Dev. 2005;19:2849-61 pubmed
    ..Not only does this mutation establish a role for Brg1 during organogenesis, it also demonstrates that ATPase activity can be uncoupled from chromatin remodeling. ..
  47. Falco G, Stanghellini I, Ko M. Use of Chuk as an internal standard suitable for quantitative RT-PCR in mouse preimplantation embryos. Reprod Biomed Online. 2006;13:394-403 pubmed
    ..of two known genes (Nalp5/Mater, Pou5f1/Oct3/Oct4) were normalized by Chuk and other housekeeping genes (Actb, Gapdh, Eef1a1, and H2afz) and demonstrated that the former was more consistent with the expression patterns obtained by ..
  48. Yogalingam G, Hwang S, Ferreira J, Mochly Rosen D. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) phosphorylation by protein kinase C? (PKC?) inhibits mitochondria elimination by lysosomal-like structures following ischemia and reoxygenation-induced injury. J Biol Chem. 2013;288:18947-60 pubmed publisher
    ..We found that I/R induces glyceraldehyde-3-phosphate dehydrogenase (GAPDH) association with mitochondria and promotes direct uptake of damaged mitochondria into multiorganellar lysosomal-..
  49. Xu W, Weissmiller A, White J, Fang F, Wang X, Wu Y, et al. Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. J Clin Invest. 2016;126:1815-33 pubmed publisher
    ..Our data strongly support the emerging concept that dysregulation of Rab5 activity contributes importantly to early pathogenesis of AD and DS. ..
  50. Narushima Y, Unno M, Nakagawara K, Mori M, Miyashita H, Suzuki Y, et al. Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma. Gene. 1997;185:159-68 pubmed
    ..These results suggest that genes of the mouse Reg family are derived from a common ancestor gene by several gene duplications, and have obtained divergency in expression and function in the process of genetic evolution. ..
  51. Bächner D, Sedlacek Z, Korn B, Hameister H, Poustka A. Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport. Hum Mol Genet. 1995;4:701-8 pubmed
    ..In contrast to rab GDI alpha/XAP-4, the human rab GDI beta is expressed ubiquitously. ..
  52. Rajamohan S, Pillai V, Gupta M, Sundaresan N, Birukov K, Samant S, et al. SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol Cell Biol. 2009;29:4116-29 pubmed publisher
    ..These data demonstrate that the activity of PARP1 is under the control of SIRT1, which is necessary for survival of cells under stress conditions. ..
  53. Blais S, Boudreau F, Beaulieu J, Asselin C. CCAAT/enhancer binding protein isoforms expression in the colon of neonatal mice. Dev Dyn. 1995;204:66-76 pubmed
    ..Differential C/EBP isoforms pattern of expression suggests a role for these transcription factors in colon-specific gene expression during development. ..
  54. You B, Huang S, Qin Q, Yi B, Yuan Y, Xu Z, et al. Glyceraldehyde-3-phosphate dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosis. PLoS ONE. 2013;8:e58697 pubmed publisher
    ..yeast two-hybrid screen of a human heart cDNA library with Mst1 as bait, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was identified as an Mst1-interacting protein...
  55. Ono Y, Watanabe M, Inoue Y, Ohmoto T, Akiyama K, Tsutsui K, et al. Developmental expression of APEX nuclease, a multifunctional DNA repair enzyme, in mouse brains. Brain Res Dev Brain Res. 1995;86:1-6 pubmed
    ..However, the present results suggested that APEX/Ref-1 gene product can interact with AP-1 binding proteins in brain, especially in the hippocampal formation, to regulate some brain functions by redox-activation. ..
  56. Bartolini F, Ramalingam N, Gundersen G. Actin-capping protein promotes microtubule stability by antagonizing the actin activity of mDia1. Mol Biol Cell. 2012;23:4032-40 pubmed publisher
  57. Hikosaka K, Ikutani M, Shito M, Kazuma K, Gulshan M, Nagai Y, et al. Deficiency of nicotinamide mononucleotide adenylyltransferase 3 (nmnat3) causes hemolytic anemia by altering the glycolytic flow in mature erythrocytes. J Biol Chem. 2014;289:14796-811 pubmed publisher
    ..the glycolysis pathway in Nmnat3-deficient erythrocytes was blocked at a glyceraldehyde 3-phosphate dehydrogenase (GAPDH) step because of the shortage of the coenzyme NAD...
  58. Fujii T, Pichel J, Taira M, Toyama R, Dawid I, Westphal H. Expression patterns of the murine LIM class homeobox gene lim1 in the developing brain and excretory system. Dev Dyn. 1994;199:73-83 pubmed
    ..In the metanephros, lim1 is strongly expressed in renal vesicles and S-shaped bodies, and transcripts are also detected in the ureteric branches. ..
  59. Sen N, Snyder S. Neurotrophin-mediated degradation of histone methyltransferase by S-nitrosylation cascade regulates neuronal differentiation. Proc Natl Acad Sci U S A. 2011;108:20178-83 pubmed publisher
    ..BDNF activates neuronal NOS with the nitrosylated GAPDH/seven in absentia (Siah) homolog complex translocating to the nucleus...
  60. Snider N, Weerasinghe S, Singla A, Leonard J, Hanada S, Andrews P, et al. Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation. J Cell Biol. 2011;195:217-29 pubmed publisher
    ..significant down-regulation, aggregation, and nuclear translocation of glyceraldehyde 3-phosphate dehydrogenase (GAPDH)...
  61. Chauhan A, Rawat P, Malhotra H, Sheokand N, Kumar M, Patidar A, et al. Secreted multifunctional Glyceraldehyde-3-phosphate dehydrogenase sequesters lactoferrin and iron into cells via a non-canonical pathway. Sci Rep. 2015;5:18465 pubmed publisher
    ..boundaries, by secreting the multifunctional housekeeping enzyme Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) into the extracellular milieu. This effect's an autocrine/paracrine acquisition of target ligand into the cell...
  62. Chen H, Kamath R, Pace J, Russell S, Hunt J. Gestation-related expression of the interferon-gamma receptor gene in mouse uterine and embryonic hematopoietic cells. J Leukoc Biol. 1994;55:617-25 pubmed
  63. Fukagawa M, Suzuki N, Hogan B, Jones C. Embryonic expression of mouse bone morphogenetic protein-1 (BMP-1), which is related to the Drosophila dorsoventral gene tolloid and encodes a putative astacin metalloendopeptidase. Dev Biol. 1994;163:175-83 pubmed
    ..5 days p.c. in the floorplate region of the developing neural tube. Potential therefore exists for the interaction of BMP-1 protein with products of TGF-beta-related genes expressed during embryogenesis. ..
  64. Wang E, Truong L, Mendoza L, Jung E, Choi Y. 28S-ribosomal RNA is superior to glyceraldehyde-3-phosphate dehydrogenase as a RNA reference gene in p53-deficient mice with unilateral ureteral obstruction. Exp Mol Pathol. 2011;91:368-72 pubmed publisher
    Although there are many kinds of reference genes, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been commonly used by many researchers to assess the amount and integrity of RNA transcripts in RNA studies including Northern blot ..
  65. Brown A, Bernier G, Mathieu M, Rossant J, Kothary R. The mouse dystonia musculorum gene is a neural isoform of bullous pemphigoid antigen 1. Nat Genet. 1995;10:301-6 pubmed
    ..We also demonstrate abnormal dystonin transcripts in a second dt mutant, dt24J. We conclude that mutations in the dystonin gene are the primary genetic lesion in dt mice...
  66. Lin G, Lu P, Zeng T, Tang H, Chen Y, Liu S, et al. GAPDH-mediated posttranscriptional regulations of sodium channel Scn1a and Scn3a genes under seizure and ketogenic diet conditions. Neuropharmacology. 2017;113:480-489 pubmed publisher
    ..Here, we reveal a novel role of GAPDH on the posttranscriptional regulation of mouse Scn1a and Scn3a expressions under seizure and KD conditions...
  67. Tan R, Li J, Peng X, Zhu L, Cai L, Wang T, et al. GAPDH is critical for superior efficacy of female bone marrow-derived mesenchymal stem cells on pulmonary hypertension. Cardiovasc Res. 2013;100:19-27 pubmed publisher
  68. Merkle S, Reitmeir P, Pretsch W. A mutation resulting in increased triosephosphate isomerase activity in Mus musculus. Genet Res. 1991;57:139-45 pubmed
    ..Mapping studies indicated that the mutation is closely linked to the Gapd locus and consequently is located either adjacent to or within the Tpi-1 structural locus...
  69. Winder A, Wittbjer A, Rosengren E, Rorsman H. The mouse brown (b) locus protein has dopachrome tautomerase activity and is located in lysosomes in transfected fibroblasts. J Cell Sci. 1993;106 ( Pt 1):153-66 pubmed
    ..These findings are consistent with the hypothesis that melanosomes are closely related to lysosomes. ..
  70. Yamamoto M, Matsuzaki T, Takahashi R, Adachi E, Maeda Y, Yamaguchi S, et al. The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs. Biol Open. 2012;1:458-66 pubmed publisher
    ..Our findings illustrate a role for Reck in the mesenchymal-epithelial interactions essential for mammalian development. ..
  71. Sabath D, Broome H, Prystowsky M. Glyceraldehyde-3-phosphate dehydrogenase mRNA is a major interleukin 2-induced transcript in a cloned T-helper lymphocyte. Gene. 1990;91:185-91 pubmed
    ..This cDNA was identified as encoding murine glyceraldehyde-3-phosphate dehydrogenase (GAPDH; EC 1.2.1.12)...
  72. Arif A, Chatterjee P, Moodt R, Fox P. Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages. Mol Cell Biol. 2012;32:5046-55 pubmed publisher
    ..EPRS), NS1-associated protein 1 (NSAP1), ribosomal protein L13a, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH)...
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