Galnt1

Summary

Gene Symbol: Galnt1
Description: polypeptide N-acetylgalactosaminyltransferase 1
Alias: polypeptide N-acetylgalactosaminyltransferase 1, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1, galNAc-T1, polypeptide GalNAc transferase 1, pp-GaNTase 1, ppGaNTase-T1, protein-UDP acetylgalactosaminyltransferase 1
Species: mouse
Products:     Galnt1

Top Publications

  1. Hagen F, Ten Hagen K, Beres T, Balys M, VanWuyckhuyse B, Tabak L. cDNA cloning and expression of a novel UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. J Biol Chem. 1997;272:13843-8 pubmed
  2. Bennett E, Mandel U, Clausen H, Gerken T, Fritz T, Tabak L. Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family. Glycobiology. 2012;22:736-56 pubmed publisher
    ..Here, we present an overview of the GalNAc-T gene family in animals and propose a classification of the genes into subfamilies, which appear to be conserved in evolution structurally as well as functionally. ..
  3. Tenno M, Ohtsubo K, Hagen F, Ditto D, Zarbock A, Schaerli P, et al. Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity. Mol Cell Biol. 2007;27:8783-96 pubmed
    ..These findings reveal that the initiation of protein O glycosylation by ppGalNAcT-1 provides a distinctive repertoire of advantageous functions that support vascular responses and humoral immunity. ..
  4. Fritz T, Hurley J, Trinh L, Shiloach J, Tabak L. The beginnings of mucin biosynthesis: the crystal structure of UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-T1. Proc Natl Acad Sci U S A. 2004;101:15307-12 pubmed
  5. Tang J, Zheng H, Chen L, Gao S, Shi X, Liu J, et al. Isoform-specific regulation of osteogenic factors by polypeptide N-Acetylgalactosaminyltransferases 1 and 4. Biochem Biophys Res Commun. 2017;482:1449-1454 pubmed publisher
    ..We also found that ppGalNAc-T1 and -T4 affected the expression of different osteogenic factors, suggesting distinct roles ppGalNAc-T isoformsplay in regulating osteogenesis in vitro. ..
  6. Gerken T, Jamison O, Perrine C, Collette J, Moinova H, Ravi L, et al. Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases. J Biol Chem. 2011;286:14493-507 pubmed publisher
    ..We conclude that each ppGalNAc T isoform may be uniquely sensitive to peptide sequence and overall charge, which together dictates the substrate sites that will be glycosylated. ..
  7. Gill D, Chia J, Senewiratne J, Bard F. Regulation of O-glycosylation through Golgi-to-ER relocation of initiation enzymes. J Cell Biol. 2010;189:843-58 pubmed publisher
    ..We propose that growth factor stimulation regulates O-glycosylation initiation in a Src-dependent fashion by GalNac-T redistribution to the ER. ..
  8. Saba L, Bhave S, Grahame N, Bice P, Lapadat R, Belknap J, et al. Candidate genes and their regulatory elements: alcohol preference and tolerance. Mamm Genome. 2006;17:669-88 pubmed
  9. Miwa H, Gerken T, Jamison O, Tabak L. Isoform-specific O-glycosylation of osteopontin and bone sialoprotein by polypeptide N-acetylgalactosaminyltransferase-1. J Biol Chem. 2010;285:1208-19 pubmed publisher
    ..Thus, we compared glycoproteins expressed in wild-type and Galnt1-null mice to identify bone-associated proteins that were glycosylated in a ppGalNAcT-1-dependent manner...

More Information

Publications19

  1. Kingsley P, Hagen K, Maltby K, Zara J, Tabak L. Diverse spatial expression patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyl-transferase family member mRNAs during mouse development. Glycobiology. 2000;10:1317-23 pubmed
    ..5 maxilla and mandible underlying the dental lamina. The unique spatiotemporal expression of the different ppGaNTase family members during development suggests unique roles for each of these gene products. ..
  2. Lu K, Ramos K. Identification of genes differentially expressed in vascular smooth muscle cells following benzo[a]pyrene challenge: implications for chemical atherogenesis. Biochem Biophys Res Commun. 1998;253:828-33 pubmed
    ..Of particular interest is the modulation of retrotransposon mRNAs which coupled to other genetic events, may play a significant role in the atherogenic response to this carcinogen. ..
  3. Block H, Ley K, Zarbock A. Severe impairment of leukocyte recruitment in ppGalNAcT-1-deficient mice. J Immunol. 2012;188:5674-81 pubmed publisher
    ..leukocyte recruitment in untreated and TNF-?-treated cremaster muscles comparing ppGalNAcT-1-deficient mice (Galnt1(-/-)) and wild-type mice...
  4. Xu Y, Pang W, Lu J, Shan A, Zhang Y. Polypeptide N-Acetylgalactosaminyltransferase 13 Contributes to Neurogenesis via Stabilizing the Mucin-type O-Glycoprotein Podoplanin. J Biol Chem. 2016;291:23477-23488 pubmed
  5. Young W, Holcomb D, Ten Hagen K, Tabak L. Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase isoforms in murine tissues determined by real-time PCR: a new view of a large family. Glycobiology. 2003;13:549-57 pubmed
  6. Zhang Y, Iwasaki H, Wang H, Kudo T, Kalka T, Hennet T, et al. Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen. J Biol Chem. 2003;278:573-84 pubmed
    ..pp-GalNAc-T13 would be a major enzyme responsible for the synthesis of O-glycan and specifically the Tn antigen epitope in neurons. ..
  7. Ten Hagen K, Bedi G, Tetaert D, Kingsley P, Hagen F, Balys M, et al. Cloning and characterization of a ninth member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, ppGaNTase-T9. J Biol Chem. 2001;276:17395-404 pubmed
    ..These findings lend further support to the existence of a hierarchical network of differential enzymatic activity within the diversely regulated ppGaNTase family, which may play a role in the various processes governing development. ..
  8. Hagen F, Hazes B, Raffo R, deSa D, Tabak L. Structure-function analysis of the UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. Essential residues lie in a predicted active site cleft resembling a lactose repressor fold. J Biol Chem. 1999;274:6797-803 pubmed
    ..Mutagenesis of highly conserved (but not invariant) carboxylates produces only modest alterations in enzyme activity. Mutations in the C-terminal 128-amino acid ricin-like lectin motif do not alter the enzyme's catalytic properties. ..
  9. Tian E, Stevens S, Guan Y, Springer D, Anderson S, Starost M, et al. Galnt1 is required for normal heart valve development and cardiac function. PLoS ONE. 2015;10:e0115861 pubmed publisher
    ..In this study we demonstrate that normal heart valve development and cardiac function are dependent upon Galnt1, the gene that encodes a member of the family of glycosyltransferases (GalNAc-Ts) responsible for the initiation ..
  10. Li C, Du Y, Yang Z, He L, Wang Y, Hao L, et al. GALNT1-Mediated Glycosylation and Activation of Sonic Hedgehog Signaling Maintains the Self-Renewal and Tumor-Initiating Capacity of Bladder Cancer Stem Cells. Cancer Res. 2016;76:1273-83 pubmed publisher
    ..Furthermore, the glycotransferase GALNT1 was highly expressed in BCMab1(+)CD44(+) cells and correlated with clinicopathologic features of bladder cancers...