Gabrg2

Summary

Gene Symbol: Gabrg2
Description: gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
Alias: GABAA-R, Gabrg-2, gamma2, gamma-aminobutyric acid receptor subunit gamma-2
Species: mouse
Products:     Gabrg2

Top Publications

  1. Quinlan J, Firestone L, Homanics G. Mice lacking the long splice variant of the gamma 2 subunit of the GABA(A) receptor are more sensitive to benzodiazepines. Pharmacol Biochem Behav. 2000;66:371-4 pubmed
    ..Lack of the gamma 2L subunits may shift the GABA(A) receptor from an inverse agonist-preferring toward an agonist-preferring configuration. ..
  2. van Zundert B, Castro P, Aguayo L. Glycinergic and GABAergic synaptic transmission are differentially affected by gephyrin in spinal neurons. Brain Res. 2005;1050:40-7 pubmed
    ..These results indicate that gephyrin is required for the membrane insertion/stabilization of the GABAAR gamma2 subunit as well as for its subsequent localization in the postsynaptic membrane.
  3. Shen Q, Lal R, Luellen B, Earnheart J, Andrews A, Luscher B. gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression. Biol Psychiatry. 2010;68:512-20 pubmed publisher
    ..GABA) Type A receptor deficits that are induced by global or forebrain-specific heterozygous inactivation of the gamma2 subunit gene in mouse embryos result in behavior indicative of trait anxiety and depressive states...
  4. Wulff P, Ponomarenko A, Bartos M, Korotkova T, Fuchs E, Bähner F, et al. Hippocampal theta rhythm and its coupling with gamma oscillations require fast inhibition onto parvalbumin-positive interneurons. Proc Natl Acad Sci U S A. 2009;106:3561-6 pubmed publisher
    ..Similar alterations in rhythmic activity were obtained in a computational hippocampal network model mimicking the genetic modification, suggesting that intrahippocampal networks might contribute to these effects. ..
  5. Lorez M, Benke D, Luscher B, Mohler H, Benson J. Single-channel properties of neuronal GABAA receptors from mice lacking the 2 subunit. J Physiol. 2000;527 Pt 1:11-31 pubmed
    1. The aim of this study was to define the biophysical properties contributed by the gamma2 subunit to native single GABAA receptors. 2...
  6. Chandra D, Korpi E, Miralles C, De Blas A, Homanics G. GABAA receptor gamma 2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines. BMC Neurosci. 2005;6:30 pubmed
    ..The gamma2 subunit is highly expressed throughout the brain...
  7. Cope D, Wulff P, Oberto A, Aller M, Capogna M, Ferraguti F, et al. Abolition of zolpidem sensitivity in mice with a point mutation in the GABAA receptor gamma2 subunit. Neuropharmacology. 2004;47:17-34 pubmed
    ..Here, we tested the in vivo contribution of the gamma2 subunit to the actions of zolpidem, an alpha1 subunit selective benzodiazepine agonist, by generating mice with a ..
  8. Crestani F, Lorez M, Baer K, Essrich C, Benke D, Laurent J, et al. Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues. Nat Neurosci. 1999;2:833-9 pubmed
    ..Synaptic clustering of GABAA receptors in mice heterozygous for the gamma2 subunit was reduced, mainly in hippocampus and cerebral cortex...
  9. Homanics G, Harrison N, Quinlan J, Krasowski M, Rick C, De Blas A, et al. Normal electrophysiological and behavioral responses to ethanol in mice lacking the long splice variant of the gamma2 subunit of the gamma-aminobutyrate type A receptor. Neuropharmacology. 1999;38:253-65 pubmed
    ..The long splice variant of the gamma2 subunit (gamma2L) has been postulated to be essential in mediating the modulatory actions of ethanol at the GABA(A)..

More Information

Publications86

  1. Lee K, Porteous R, Campbell R, Luscher B, Herbison A. Knockdown of GABA(A) receptor signaling in GnRH neurons has minimal effects upon fertility. Endocrinology. 2010;151:4428-36 pubmed publisher
    ..Using a Cre-LoxP strategy, we generated a targeted mouse line, in which all (98 +/- 1%) GnRH neurons had the gamma2-subunit of the GABA(A) receptor deleted...
  2. Gunther U, Benson J, Benke D, Fritschy J, Reyes G, Knoflach F, et al. Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors. Proc Natl Acad Sci U S A. 1995;92:7749-53 pubmed
    ..The lack of postnatal GABAA receptor regulation by endogenous ligands of BZ sites might contribute to this phenotype...
  3. Keller C, Yuan X, Panzanelli P, Martin M, Alldred M, Sassoè Pognetto M, et al. The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ. J Neurosci. 2004;24:5881-91 pubmed
    ..neurotransmitter GABA activates heteropentameric GABA(A) receptors, which are composed mostly of alpha, beta, and gamma2 subunits...
  4. Tan H, Reid C, Single F, Davies P, Chiu C, Murphy S, et al. Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy. Proc Natl Acad Sci U S A. 2007;104:17536-41 pubmed
    Mutations in the GABA(A) receptor gamma2 subunit are associated with childhood absence epilepsy and febrile seizures...
  5. Yuan X, Yao J, Norris D, Tran D, Bram R, Chen G, et al. Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors. Mol Cell Neurosci. 2008;38:277-89 pubmed publisher
    ..at GABAergic synapses requires the cytoplasmic loop region and C-terminal transmembrane domain of the receptor gamma2 subunit...
  6. Chiu C, Reid C, Tan H, Davies P, Single F, Koukoulas I, et al. Developmental impact of a familial GABAA receptor epilepsy mutation. Ann Neurol. 2008;64:284-93 pubmed publisher
    ..A human GABA(A) gamma2 gene mutation (R43Q) is associated with generalized epilepsy...
  7. Essrich C, Lorez M, Benson J, Fritschy J, Luscher B. Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrin. Nat Neurosci. 1998;1:563-71 pubmed
    ..The gamma 2 subunit and gephyrin are thus interdependent components of the same synaptic complex that is critical for postsynaptic clustering of abundant subtypes of GABAA receptors in vivo. ..
  8. Schweizer C, Balsiger S, Bluethmann H, Mansuy I, Fritschy J, Mohler H, et al. The gamma 2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapses. Mol Cell Neurosci. 2003;24:442-50 pubmed
    The gamma2 subunit of GABA(A) receptor chloride channels is required for normal channel function and for postsynaptic clustering of these receptors during synaptogenesis...
  9. Earnheart J, Schweizer C, Crestani F, Iwasato T, Itohara S, Mohler H, et al. GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states. J Neurosci. 2007;27:3845-54 pubmed
    ..Mice that are heterozygous for the gamma2 subunit of GABA(A) receptors exhibit a modest functional deficit in mainly postsynaptic GABA(A) receptors that is ..
  10. Wulff P, Goetz T, Leppä E, Linden A, Renzi M, Swinny J, et al. From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors. Nat Neurosci. 2007;10:923-9 pubmed
    ..modulator that enhances the function of the GABAA receptor, requires a phenylalanine residue (Phe77) in the gamma2 subunit. Mice in which this residue is changed to isoleucine are insensitive to zolpidem...
  11. Maguire J, Mody I. GABA(A)R plasticity during pregnancy: relevance to postpartum depression. Neuron. 2008;59:207-13 pubmed publisher
    ..decrease in tonic and phasic inhibitions in pregnant mice, mediated by a downregulation of GABA(A)R delta and gamma2 subunits, respectively, which rebounds immediately postpartum...
  12. Wulff P, Schonewille M, Renzi M, Viltono L, Sassoè Pognetto M, Badura A, et al. Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning. Nat Neurosci. 2009;12:1042-9 pubmed publisher
  13. Kang J, Shen W, Zhou C, Xu D, Macdonald R. The human epilepsy mutation GABRG2(Q390X) causes chronic subunit accumulation and neurodegeneration. Nat Neurosci. 2015;18:988-96 pubmed publisher
    ..We have now developed a model of a severe human genetic epileptic encephalopathy, the Gabrg2(+/Q390X) knock-in mouse...
  14. Kang J, Shen W, Macdonald R. The GABRG2 mutation, Q351X, associated with generalized epilepsy with febrile seizures plus, has both loss of function and dominant-negative suppression. J Neurosci. 2009;29:2845-56 pubmed publisher
    The GABA(A) receptor gamma2 subunit mutation, Q351X, associated with generalized epilepsy with febrile seizures plus (GEFS+), created a loss of function with homozygous expression...
  15. Kneussel M, Haverkamp S, Fuhrmann J, Wang H, Wassle H, Olsen R, et al. The gamma-aminobutyric acid type A receptor (GABAAR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse. Proc Natl Acad Sci U S A. 2000;97:8594-9 pubmed
    ..Recently, the GABA(A)R-associated protein GABARAP was found to bind to the gamma2 subunit of GABA(A)Rs...
  16. Reid C, Kim T, Phillips A, Low J, Berkovic S, Luscher B, et al. Multiple molecular mechanisms for a single GABAA mutation in epilepsy. Neurology. 2013;80:1003-8 pubmed publisher
    ..These mouse studies help to provide a conceptual framework within which clinical heterogeneity seen in genetic epilepsy can be explained. ..
  17. Cheng Q, Yeh P, Yeh H. Cajal-Retzius cells switch from expressing gamma-less to gamma-containing GABA receptors during corticogenesis. Eur J Neurosci. 2006;24:2145-51 pubmed
    ..We conclude that Cajal-Retzius cells express gamma-less GABA(A) receptors at embryonic stages and switch to expressing gamma-containing GABA(A) receptor isoforms during postnatal neocortical development. ..
  18. Hoon M, Sinha R, Okawa H, Suzuki S, Hirano A, BRECHA N, et al. Neurotransmission plays contrasting roles in the maturation of inhibitory synapses on axons and dendrites of retinal bipolar cells. Proc Natl Acad Sci U S A. 2015;112:12840-5 pubmed publisher
    ..Thus, inhibitory neurotransmission regulates in vivo postsynaptic maturation of inhibitory synapses with contrasting modes of action specific to synapse type and location. ..
  19. Tanabe Y, Naito Y, Vasuta C, Lee A, Soumounou Y, Linhoff M, et al. IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2?. Nat Commun. 2017;8:408 pubmed publisher
    ..Here the authors show that IgSF21 interacts with neurexin2? to induce presynaptic differentiation of inhibitory synapses, and that mice lacking IgSF21 exhibit deficits in inhibitory synaptic transmission. ..
  20. Rovó Z, Matyas F, Bartho P, Slézia A, Lecci S, Pellegrini C, et al. Phasic, nonsynaptic GABA-A receptor-mediated inhibition entrains thalamocortical oscillations. J Neurosci. 2014;34:7137-47 pubmed publisher
    ..We conclude that nonsynaptic GABA-ARs are recruited in a phasic manner specifically during burst firing of nRT cells and provide sufficient GABA-AR activation to control major thalamocortical oscillations. ..
  21. Hood H, Metten P, Crabbe J, Buck K. Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11. Genes Brain Behav. 2006;5:1-10 pubmed
    ..Our results, together with recent knockout studies, point to the GABA(A) receptor gamma2 subunit gene (Gabrg2) as a promising candidate gene to underlie phenotypic differences in sedative-hypnotic physiological dependence ..
  22. Maljevic S, Reid C, Petrou S. Models for discovery of targeted therapy in genetic epileptic encephalopathies. J Neurochem. 2017;143:30-48 pubmed publisher
  23. Pannell C, Simonian S, Gillies G, Luscher B, Herbison A. Hypothalamic somatostatin and growth hormone-releasing hormone mRNA expression depend upon GABA(A) receptor expression in the developing mouse. Neuroendocrinology. 2002;76:93-8 pubmed
  24. Chen X, Whissell P, Orser B, MacDonald J. Functional modifications of acid-sensing ion channels by ligand-gated chloride channels. PLoS ONE. 2011;6:e21970 pubmed publisher
    ..We conclude that GABA(A) receptors and glycine receptors modify ASICs in neurons through mechanisms that require the opening of chloride channels. ..
  25. Luntz Leybman V, Rotter A, Zdilar D, Frostholm A. Uncoupling of GABAA/benzodiazepine receptor alpha 1, beta 2, and gamma 2 subunit mRNA expression in cerebellar Purkinje cells of staggerer mutant mice. J Neurosci. 1995;15:8121-30 pubmed
    ..The present studies indicate that in cerebellar Purkinje cells, the GABAA/BZ receptor alpha 1, and beta 2, and gamma 2, subunit mRNAs are regulated by distinct mechanisms which are differentially affected by the staggerer mutation. ..
  26. Woll K, Murlidaran S, Pinch B, Hénin J, Wang X, Salari R, et al. A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of ?-Aminobutyric Acid, Type A (GABAA), Receptor Subunit Binding Selectivity in Synaptosomes. J Biol Chem. 2016;291:20473-86 pubmed publisher
  27. Tyler A, McGarr T, Beyer B, Frankel W, Carter G. A genetic interaction network model of a complex neurological disease. Genes Brain Behav. 2014;13:831-40 pubmed publisher
    ..These results illustrate the power of CAPE in identifying novel modifier loci and interactions in a complex neurological disease, toward a more comprehensive view of its underlying genetic architecture. ..
  28. Jelinek D, Partridge L. GABA(A) receptor mediated inhibition contributes to corticostriatal frequency filtering. Neurosci Lett. 2012;530:133-7 pubmed publisher
    ..Our results suggest a model whereby a temporary decrease in GABA level would modulate the filtering parameters of the corticostriatal circuit, allowing a more robust induction of high frequency-dependent plasticity. ..
  29. Mizokami A, Tanaka H, Ishibashi H, Umebayashi H, Fukami K, Takenawa T, et al. GABA(A) receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice. J Neurochem. 2010;114:302-10 pubmed publisher
    ..alpha subunit affects diazepam sensitivity; alpha1, 2, 3, and 5 subunits assemble with any form of beta and the gamma2 subunits to produce diazepam-sensitive receptors, whereas alpha4 or alpha6/beta/gamma2 receptors are diazepam-..
  30. Tsuchiya H, Oka T, Nakamura K, Ichikawa A, Saper C, Sugimoto Y. Prostaglandin E2 attenuates preoptic expression of GABAA receptors via EP3 receptors. J Biol Chem. 2008;283:11064-71 pubmed publisher
    ..Indeed, we found that most EP3-positive neurons in the mouse preoptic area are positive for the alpha2 or gamma2 GABA(A) receptor subunit...
  31. Mou L, Dias B, Gosnell H, Ressler K. Gephyrin plays a key role in BDNF-dependent regulation of amygdala surface GABAARs. Neuroscience. 2013;255:33-44 pubmed publisher
    ..This work may inform future studies aimed at elucidating the pathways connecting BDNF, GABAA systems, gephyrin, and their role in underlying amygdala-dependent learning. ..
  32. Cutting G, Curristin S, Zoghbi H, O HARA B, Seldin M, Uhl G. Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. Genomics. 1992;12:801-6 pubmed
    ..This close physical association and high degree of sequence similarity raises the possibility that one rho gene arose from the other by duplication. ..
  33. Shivers B, Killisch I, Sprengel R, Sontheimer H, Kohler M, Schofield P, et al. Two novel GABAA receptor subunits exist in distinct neuronal subpopulations. Neuron. 1989;3:327-37 pubmed
    ..These findings have implications for the composition of two different GABAA receptor subtypes and for information processing in networks using GABA for signaling. ..
  34. Seifi M, Brown J, Mills J, Bhandari P, Belelli D, Lambert J, et al. Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon. J Neurosci. 2014;34:10361-78 pubmed publisher
    ..The study demonstrates the molecular and functional diversity of the GABAAR system within the mouse colon providing a framework for developing GABAAR-based therapeutics in GI disorders. ..
  35. Berry R, Chandra D, Diaz Granados J, Homanics G, Matthews D. Investigation of ethanol-induced impairment of spatial memory in gamma2 heterozygous knockout mice. Neurosci Lett. 2009;455:84-7 pubmed publisher
    ..benzodiazepines and ethanol have similar effect signatures, it has been hypothesized that these drugs share the gamma2-containing GABA(A) receptors as a mechanism of action...
  36. Hales T, Deeb T, Tang H, Bollan K, King D, Johnson S, et al. An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunits. J Biol Chem. 2006;281:17034-43 pubmed
    ..The familial epilepsy gamma2(K289M) mutation affects a basic residue conserved in the TM2-3 linker of most GABAA subunits...
  37. Muller E, Triller A, Legendre P. Glycine receptors and GABA receptor alpha 1 and gamma 2 subunits during the development of mouse hypoglossal nucleus. Eur J Neurosci. 2004;20:3286-300 pubmed
    ..codetection of VIAAT, the common presynaptic vesicular transporter of glycine and GABA, GlyRs, GABA(A)R alpha1 and gamma2 subunits, and gephyrin, the scaffold protein implicated in the synaptic localization of inhibitory receptors...
  38. Hales T, Tang H, Bollan K, Johnson S, King D, McDonald N, et al. The epilepsy mutation, gamma2(R43Q) disrupts a highly conserved inter-subunit contact site, perturbing the biogenesis of GABAA receptors. Mol Cell Neurosci. 2005;29:120-7 pubmed
    Given the association of a gamma2 mutation (R43Q) with epilepsy and the reduced cell surface expression of mutant receptors, we investigated a role for this residue in alpha1beta2gamma2 receptor assembly when present in each subunit...
  39. Warner T, Liu Z, Macdonald R, Kang J. Heat induced temperature dysregulation and seizures in Dravet Syndrome/GEFS+ Gabrg2+/Q390X mice. Epilepsy Res. 2017;134:1-8 pubmed publisher
    ..febrile seizures (FS) plus (GEFS+) and Dravet syndrome have been associated with mutations especially in SCN1A and GABRG2 genes...
  40. Dredge B, Darnell R. Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer. Mol Cell Biol. 2003;23:4687-700 pubmed
    ..Here, we have biochemically confirmed the observation that splicing regulation of the inhibitory GABA(A) receptor gamma2 (GABA(A)Rgamma2) subunit pre-mRNA exon E9 is disrupted in mice lacking Nova-1...
  41. Mesbah Oskui L, Orser B, Horner R. Thalamic δ-subunit containing GABAA receptors promote electrocortical signatures of deep non-REM sleep but do not mediate the effects of etomidate at the thalamus in vivo. J Neurosci. 2014;34:12253-66 pubmed publisher
    ..These results indicate that thalamic δGABAARs promote electrocortical signatures of deep NREM sleep, but do not mediate the effects of etomidate at the thalamus in vivo. ..
  42. Dellovade T, Davis A, Ferguson C, Sieghart W, Homanics G, Tobet S. GABA influences the development of the ventromedial nucleus of the hypothalamus. J Neurobiol. 2001;49:264-76 pubmed
    ..These data suggest that GABA is important for the organization of cells during VMH formation. ..
  43. Delprato A, Bonheur B, Algéo M, Rosay P, Lu L, Williams R, et al. Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice. Genes Brain Behav. 2015;14:591-606 pubmed publisher
    ..Gpc4 and Tenm2 are strong candidate genes that may modulate IIPMF areas. Analysis of gene expression networks and trait correlations highlight several processes influencing morphometrical variation and spatial learning. ..
  44. Levi S, Logan S, Tovar K, Craig A. Gephyrin is critical for glycine receptor clustering but not for the formation of functional GABAergic synapses in hippocampal neurons. J Neurosci. 2004;24:207-17 pubmed
    ..1999) reported a complete loss of synaptic clusters of the major GABA(A)R subunits alpha2 and gamma2 in hippocampal neurons lacking gephyrin...
  45. Passlick S, Grauer M, Schäfer C, Jabs R, Seifert G, Steinhäuser C. Expression of the ?2-subunit distinguishes synaptic and extrasynaptic GABA(A) receptors in NG2 cells of the hippocampus. J Neurosci. 2013;33:12030-40 pubmed publisher
    ..GABA-induced depolarization in NG2 cells might trigger Ca²? influx through voltage-activated Ca²? channels. ..
  46. Lo W, Lagrange A, Hernandez C, Gurba K, Macdonald R. Co-expression of ?2 subunits hinders processing of N-linked glycans attached to the N104 glycosylation sites of GABAA receptor ?2 subunits. Neurochem Res. 2014;39:1088-103 pubmed publisher
    ..This ?2 subunit-dependent effect was strong enough that a decrease of ?2 subunit expression in heterozygous GABRG2 knockout (?2(+/-)) mice led to appreciable changes in the endoglycosidase H digestion pattern of neuronal ?2 ..
  47. Hortnagl H, Tasan R, Wieselthaler A, Kirchmair E, Sieghart W, Sperk G. Patterns of mRNA and protein expression for 12 GABAA receptor subunits in the mouse brain. Neuroscience. 2013;236:345-72 pubmed publisher
    ..Although in general there is a considerable correspondence in the distribution between mouse and rat brains, several species-specific differences were observed. ..
  48. Kim E, Wu Z, Sun H, Xu Y, Mangieri L, Xu Y, et al. Hypothalamic Non-AgRP, Non-POMC GABAergic Neurons Are Required for Postweaning Feeding and NPY Hyperphagia. J Neurosci. 2015;35:10440-50 pubmed publisher
    ..Thus, these results signify an importance to study those yet to be defined hypothalamic neurons in the regulation of energy balance and reveal a neural basis for postweaning (nocturnal) feeding and NPY-mediated hyperphagia. ..
  49. Kim T, Richards K, Heng J, Petrou S, Reid C. Two lines of transgenic mice expressing cre-recombinase exhibit increased seizure susceptibility. Epilepsy Res. 2013;104:11-6 pubmed publisher
    ..These data highlight that appropriate control experiments that compare wild-type mice to those that carry the cre-transgene but not the loxP-flanked target are essential when using this method. ..
  50. Kudryavtsev D, Shelukhina I, Son L, Ojomoko L, Kryukova E, Lyukmanova E, et al. Neurotoxins from snake venoms and α-conotoxin ImI inhibit functionally active ionotropic γ-aminobutyric acid (GABA) receptors. J Biol Chem. 2015;290:22747-58 pubmed publisher
  51. Whiting P, McKernan R, Iversen L. Another mechanism for creating diversity in gamma-aminobutyrate type A receptors: RNA splicing directs expression of two forms of gamma 2 phosphorylation site. Proc Natl Acad Sci U S A. 1990;87:9966-70 pubmed
    ..This mechanism for creating GABAA receptor diversity may allow differential regulation of the function of receptor subtypes. ..
  52. Kerti Szigeti K, Nusser Z, Eyre M. Synaptic GABAA receptor clustering without the γ2 subunit. J Neurosci. 2014;34:10219-33 pubmed publisher
  53. Luntz Leybman V, Frostholm A, Fernando L, de Blas A, Rotter A. GABAA/benzodiazepine receptor gamma 2 subunit gene expression in developing normal and mutant mouse cerebellum. Brain Res Mol Brain Res. 1993;19:9-21 pubmed
    ..Our results suggest that developing Purkinje cells express the gamma 2 gene at a time prior to receiving GABAergic inhibitory input, and that the continued expression in the adult is not affected by the absence of afferents. ..
  54. Kofuji P, Wang J, Moss S, Huganir R, Burt D. Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing. J Neurochem. 1991;56:713-5 pubmed
    ..The eight-amino-acid insertion encodes a potential consensus serine phosphorylation site for protein kinase C. These results suggest a novel mechanism for the regulation of the GABAA receptor by protein phosphorylation. ..
  55. Wu Z, Kim E, Sun H, Xu Y, Mangieri L, Li D, et al. GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding. J Neurosci. 2015;35:3312-8 pubmed publisher
    ..In addition, disruption of GABA-A receptors in the PVH reduced feeding. Thus, we have identified a new feeding pathway in which GABAergic projections from the LH to the PVH promote feeding. ..
  56. Kretschmannova K, Hines R, Revilla Sanchez R, Terunuma M, Tretter V, Jurd R, et al. Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol. J Neurosci. 2013;33:7264-73 pubmed publisher
    ..Collectively, these observations suggest that potentiation of tonic inhibition mediated by ?4 subunit containing GABAARs contributes to the hypnotic and amnestic actions of the intravenous anesthetics, etomidate and propofol. ..
  57. Galliano E, Potters J, Elgersma Y, Wisden W, Kushner S, De Zeeuw C, et al. Synaptic transmission and plasticity at inputs to murine cerebellar Purkinje cells are largely dispensable for standard nonmotor tasks. J Neurosci. 2013;33:12599-618 pubmed publisher
  58. Nani F, Bright D, Revilla Sanchez R, Tretter V, Moss S, Smart T. Tyrosine phosphorylation of GABAA receptor ?2-subunit regulates tonic and phasic inhibition in the thalamus. J Neurosci. 2013;33:12718-27 pubmed publisher
  59. Houston C, Lee H, Hosie A, Moss S, Smart T. Identification of the sites for CaMK-II-dependent phosphorylation of GABA(A) receptors. J Biol Chem. 2007;282:17855-65 pubmed
    ..of directly phosphorylating GABA(A) receptors and activating endogenous tyrosine kinases to phosphorylate the gamma2 subunit in NG108-15 cells...
  60. McDowell K, Hutchinson A, Wong Goodrich S, Presby M, Su D, Rodriguiz R, et al. Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice. J Neurosci. 2010;30:7453-65 pubmed publisher
    ..Together, these data reveal novel roles for CaRF in the organization and/or function of neural circuits that underlie essential aspects of learning and memory. ..
  61. Brünig I, Suter A, Knuesel I, Luscher B, Fritschy J. GABAergic terminals are required for postsynaptic clustering of dystrophin but not of GABA(A) receptors and gephyrin. J Neurosci. 2002;22:4805-13 pubmed
    ..This was confirmed in hippocampal neurons cultured from GABA(A) receptor gamma2 subunit-deficient mice...
  62. Hood H, Buck K. Allelic variation in the GABA A receptor gamma2 subunit is associated with genetic susceptibility to ethanol-induced motor incoordination and hypothermia, conditioned taste aversion, and withdrawal in BXD/Ty recombinant inbred mice. Alcohol Clin Exp Res. 2000;24:1327-34 pubmed
    ..Candidate genes within this QTL encode the gamma-aminobutyric acid type A (GABA A) receptor gamma2, alpha1, alpha6, and beta2 subunits...
  63. Kneussel M, Brandstätter J, Laube B, Stahl S, Muller U, Betz H. Loss of postsynaptic GABA(A) receptor clustering in gephyrin-deficient mice. J Neurosci. 1999;19:9289-97 pubmed
    ..and postsynaptic gephyrin clusters are absent from cortical cultures of mice deficient for the GABA(A) receptor gamma2 subunit...
  64. Uygun D, Ye Z, Zecharia A, Harding E, Yu X, Yustos R, et al. Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons. J Neurosci. 2016;36:11171-11184 pubmed
    ..This knowledge could help in the design of sleeping pills that induce a more natural sleep. ..
  65. Vargas E, Petrou S, Reid C. Genetic and pharmacological modulation of giant depolarizing potentials in the neonatal hippocampus associates with increased seizure susceptibility. J Physiol. 2013;591:57-65 pubmed publisher
    ..These results provide evidence that a human GABA(A) receptor epilepsy mutation exerts a developmental influence by modulating the number of GDPs. It also draws attention to the potential risk of early treatment with bumetanide. ..
  66. Hu X, Cheng X, Cai L, Tan G, Xu L, Feng X, et al. Conditional deletion of NRSF in forebrain neurons accelerates epileptogenesis in the kindling model. Cereb Cortex. 2011;21:2158-65 pubmed publisher
    ..Furthermore, the derepression of BDNF was associated by activation of PLC? and PI(3)K signaling pathways. These findings indicate that NRSF functions as an intrinsic repressor of limbic epileptogenesis. ..
  67. Yamasaki T, Hoyos Ramirez E, Martenson J, Morimoto Tomita M, Tomita S. GARLH Family Proteins Stabilize GABAA Receptors at Synapses. Neuron. 2017;93:1138-1152.e6 pubmed publisher
    ..These findings provide new insights into the regulation of inhibitory transmission and the molecular constituents of native anion channels in vivo. ..
  68. Cope D, Halbsguth C, Karayannis T, Wulff P, Ferraguti F, Hoeger H, et al. Loss of zolpidem efficacy in the hippocampus of mice with the GABAA receptor gamma2 F77I point mutation. Eur J Neurosci. 2005;21:3002-16 pubmed
    ..Here, we have tested the effects of zolpidem on the hippocampus of gamma2 subunit (gamma2F77I) point mutant mice...
  69. Wang J, Liu S, Haditsch U, Tu W, Cochrane K, Ahmadian G, et al. Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapses. J Neurosci. 2003;23:826-36 pubmed
    ..Thus, an activity-dependent physical and functional interaction between CaN and GABA(A) receptors is both necessary and sufficient for inducing LTD at CA1 individual inhibitory synapses. ..
  70. Tretter V, Hauer B, Nusser Z, Mihalek R, Hoger H, Homanics G, et al. Targeted disruption of the GABA(A) receptor delta subunit gene leads to an up-regulation of gamma 2 subunit-containing receptors in cerebellar granule cells. J Biol Chem. 2001;276:10532-8 pubmed
    ..The availability of the delta subunit, thus, influences the level of expression or the extent of assembly of the gamma(2) subunit, although these two subunits do not occur in the same receptor. ..
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