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| Gabra5SummaryGene Symbol: Gabra5 Description: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5 Alias: A230018I05Rik, GABA(A) receptor subunit alpha-5, GABAA receptor alpha5 subunit, gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 5, gamma-aminobutyric acid receptor subunit alpha-5, ligand-gated ion channel subunit Species: mouse Top Publications
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Publications
Alpha5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memoryLoren J Martin
Department of Physiology, Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada
J Neurosci 30:5269-82. 2010..potentials in hippocampal slices from both wild-type and null mutant mice for the alpha5 subunit of the GABA(A)R (Gabra5(-/-) mice). In addition, the strength of fear-associated memory was studied...
Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptorsValerie B Caraiscos
Institute of Medical Science, Department of Anesthesia, University of Toronto, Toronto, ON, Canada M5S 1A8
Proc Natl Acad Sci U S A 101:3662-7. 2004....- Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or deltaStephane F Maison
Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
J Neurosci 26:10315-26. 2006..Results suggest that the GABAergic component of the olivocochlear system contributes to the long-term maintenance of hair cells and neurons in the inner ear... 
Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptorNeil Collinson
Neuroscience Research Center, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, CM20 2QR, United Kingdom
J Neurosci 22:5572-80. 2002..These data suggest that alpha5-containing GABA(A) receptors play a key role in cognitive processes by controlling a component of synaptic transmission in the CA1 region of the hippocampus...- Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABA A receptor alpha5 subunit-deficient miceJoseph Glykys
Interdepartmental PhD Program for Neuroscience and Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
J Neurophysiol 95:2796-807. 2006..in CA1 and CA3 PCs, we quantified changes in tonic inhibition and examined network excitability in slices of adult gabra5-/- mice... - Gene expression changes in GABA(A) receptors and cognition following chronic ketamine administration in miceSijie Tan
Brain Research Center, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong S A R, China
PLoS ONE 6:e21328. 2011..In particular, there was a significant up-regulation of both mRNA and protein levels of the alpha 5 subunit (Gabra5) of the GABA(A) receptors in the prefrontal cortex... - Alpha5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidateVictor Y Cheng
Institute of Medical Science, Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
J Neurosci 26:3713-20. 2006..Thus, the amnestic and sedative-hypnotic properties of etomidate can be dissociated on the basis of GABAAR subtype pharmacology... - Role of GABAA alpha5-containing receptors in ethanol reward: the effects of targeted gene deletion, and a selective inverse agonistDavid N Stephens
Department of Psychology, School of Life Sciences, University of Sussex, Brighton, BN1 9QG, UK
Eur J Pharmacol 526:240-50. 2005..Although inverse agonists acting at alpha5-containing receptors reduce ethanol self-administration, alpha5 subunits may not be essential to signaling ethanol reward... - Physical mapping of the pink-eyed dilution complex in mouse chromosome 7 shows that Atp10c is the only transcript between Gabrb3 and Ube3aMadhu S Dhar
318 Jessie Harris Building, Department of Nutrition, University of Tennessee, 1215 Cumberland Avenue, Knoxville, TN 37996, USA
DNA Seq 15:306-9. 2004..Data show that Atp10c, a novel type IV ATPase a putative phospholipid transporter, is the only coding unit in this region of the chromosome... - Mapping of putative ether-anesthesia resistance gene using C57BL/6J and MSM/Ms mouse strainsTsuneo Megumi
Research Institute for Advanced Science and Technology, Osaka Prefecture University, Sakai, Japan
J Anesth 18:267-76. 2004..We attempted to identify the locations of major mouse genes responsible for sensitivity to diethylether (ether) anesthesia, using microsatellite linkage analyses including Quantitative Trait Locus (QTL) analysis... - Selective enhancement of tonic GABAergic inhibition in murine hippocampal neurons by low concentrations of the volatile anesthetic isofluraneValerie B Caraiscos
Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada
J Neurosci 24:8454-8. 2004..These studies suggest that an increased tonic inhibition in the hippocampus may contribute to amnestic properties of volatile anesthetics... - The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampusJoseph Glykys
Interdepartmental PhD Program for Neuroscience and Departments of Neurology and Physiology, The David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
J Physiol 582:1163-78. 2007..Our results are consistent with most of hippocampal tonic inhibitory current being mediated by GABA released from the very vesicles responsible for activating phasic inhibition... - Hippocampal alpha 5 subunit-containing GABA A receptors are involved in the development of the latent inhibition effectT V Gerdjikov
Laboratory of Behavioral Neurobiology, ETH Zurich, Schwerzenbach, Switzerland
Neurobiol Learn Mem 89:87-94. 2008..This observed phenotype suggests that specific activation of these extrasynaptic GABA(A) receptors may confer therapeutic potential against the failure to show selectivity in learning by human psychotic patients... - The sedative but not the memory-blocking properties of ethanol are modulated by α5-subunit-containing γ-aminobutyric acid type A receptorsLoren J Martin
Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Behav Brain Res 217:379-85. 2011..Null mutant mice lacking the α5 subunit (Gabra5-/-) and wild-type mice were equally impaired in contextual fear conditioning by moderate (1mg/kg) and high (1... - Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after strokeAndrew N Clarkson
Department of Neurology, The David Geffen School of Medicine at UCLA, 635 Charles Young Drive South, Los Angeles, California 90095, USA
Nature 468:305-9. 2010..Together, our results identify new pharmacological targets and provide the rationale for a novel strategy to promote recovery after stroke and possibly other brain injuries... - GABAA receptor signaling in caudal periaqueductal gray regulates maternal aggression and maternal care in miceGrace Lee
University of Wisconsin, Zoology Department, 1117 West Johnson Street, Madison, WI 53706, USA
Behav Brain Res 213:230-7. 2010.... - A reduction in hippocampal GABAA receptor alpha5 subunits disrupts the memory for location of objects in miceL Prut
Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
Genes Brain Behav 9:478-88. 2010.... - alpha5 Subunit-containing GABA(A) receptors mediate a slowly decaying inhibitory synaptic current in CA1 pyramidal neurons following Schaffer collateral activationMariana Vargas-Caballero
Department of Physiology, Anatomy and Genetics, University of Oxford, Sherrington Building, Parks Road, Oxford OX1 3PT, United Kingdom
Neuropharmacology 58:668-75. 2010..Furthermore, the L-655,708-sensitive current was absent in recordings from mice lacking alpha5GABA(A)Rs (gabra5(-/-) mice)... - The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing two distinct types of alpha subunitsEla Balic
Institute of Pharmacology and Toxicology, University of Zurich, Winterhurerstrasse, Zurich, Switzerland
J Neurochem 110:244-54. 2009..These findings imply an important role of histidine 105 in determining the position of the alpha5 subunit within the receptor complex by determining the affinity for assembly with the gamma2 subunit... - Which GABA(A) receptor subunits are necessary for tonic inhibition in the hippocampus?Joseph Glykys
Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, California 90095, USA
J Neurosci 28:1421-6. 2008..We have shown previously that mice lacking alpha5 subunits (Gabra5-/-) have a residual tonic current in CA1/CA3 PCs because of an upregulation of delta subunits, but the basis of .. - Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferationMichael Andäng
Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden
Nature 451:460-4. 2008..These results indicate the presence of a fundamentally different mechanism of proliferation control in these stem cells, in comparison with most somatic cells, involving proteins in the DNA damage checkpoint pathway... - Alpha5GABAA receptors regulate the intrinsic excitability of mouse hippocampal pyramidal neuronsRobert P Bonin
Department of Physiology, University of Toronto, Toronto, ON, Canada
J Neurophysiol 98:2244-54. 2007..We conclude that shunting inhibition mediated by alpha5GABA(A) receptors regulates the firing of action potentials and may synchronize network activity that underlies hippocampal-dependent behavior... - GABA receptors containing the alpha5 subunit mediate the trace effect in aversive and appetitive conditioning and extinction of conditioned fearBenjamin K Yee
Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, CH 8603 Schwerzenbach, Switzerland
Eur J Neurosci 20:1928-36. 2004..Our results identify neuronal inhibition in the hippocampus mediated via alpha5 GABAA receptors as a critical control element in the regulation of the acquisition and expression of associative memory... - Alpha 5 subunit-containing GABAA receptors affect the dynamic range of mouse hippocampal kainate-induced gamma frequency oscillations in vitroS K Towers
School of Biomedical Sciences, University of Leeds, LS2 9NQ, UK
J Physiol 559:721-8. 2004..The data suggest that loss of this GABAA receptor subunit alters the dynamic profile of gamma oscillations to changes in network drive, possibly via actions of GABA at extrasynaptic receptors... - Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in miceCarolien van Rijnsoever
Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland
J Neurosci 24:6785-90. 2004..Thus, the chronic activation of alpha(5)-GABA(A) receptors is crucial for the normal development of sedative tolerance to diazepam, which manifests itself in conjunction with alpha1-GABA(A) receptors... - Concordance between isolated cleft palate in mice and alterations within a region including the gene encoding the beta 3 subunit of the type A gamma-aminobutyric acid receptorC T Culiat
Biology Division, Oak Ridge National Laboratory, TN 37831 8077
Proc Natl Acad Sci U S A 90:5105-9. 1993..bracketed by the genes encoding the alpha 5 and beta 3 subunits of the type A gamma-aminobutyric acid receptor (Gabra5 and Gabrb3, respectively), contains a gene(s) (cp1; cleft palate 1) necessary for normal palate development... - High-resolution mapping of the gamma-aminobutyric acid receptor subunit beta 3 and alpha 5 gene cluster on chromosome 15q11-q13, and localization of breakpoints in two Angelman syndrome patientsD Sinnett
Genetics Division, Children s Hospital, Boston, MA 02115
Am J Hum Genet 52:1216-29. 1993..to determine the genomic organization of the GABAA receptor beta 3 subunit gene (GABRB3) and alpha 5 subunit gene (GABRA5) in chromosome 15q11-q13, we have constructed a high-resolution physical map using the combined techniques of .. - FISH ordering of reference markers and of the gene for the alpha 5 subunit of the gamma-aminobutyric acid receptor (GABRA5) within the Angelman and Prader-Willi syndrome chromosomal regionsJ H Knoll
Genetics Division, Children s Hospital, Boston, MA 02115
Hum Mol Genet 2:183-9. 1993..Our results provide a framework map of chromosome 15q11-q13 into which additional markers can be oriented and allow a further differentiation of the critical genetic regions of the two syndromes... - Phenotypic consequences of deletion of the gamma 3, alpha 5, or beta 3 subunit of the type A gamma-aminobutyric acid receptor in miceC T Culiat
Biology Division, University of Tennessee Oak Ridge Graduate School of Biomedical Sciences, Oak Ridge National Laboratory, TN 37831 8077
Proc Natl Acad Sci U S A 91:2815-8. 1994Three genes (Gabrg3, Gabra5, and Gabrb3) encoding the gamma 3, alpha 5, and beta 3 subunits of the type A gamma-aminobutyric acid receptor, respectively, are known to map near the pink-eyed dilution (p) locus in mouse chromosome 7... - The original pink-eyed dilution mutation (p) arose in Asiatic mice: implications for the H4 minor histocompatibility antigen, Myod1 regulation and the origin of inbred strainsM H Brilliant
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
Genetics 138:203-11. 1994..DNA (about 5 cM), including the loci Myod1, p, three clustered GABAA receptor subunit loci (Gabrg3, Gabra5 and Gabrb3), and Snrpn... - The gamma-aminobutyric acid receptor gamma 3 subunit gene (GABRG3) is tightly linked to the alpha 5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientationV Greger
Genetics Division, Children s Hospital, Boston, MA 02115, USA
Genomics 26:258-64. 1995..One such cluster, which consists of the GABAA receptor beta 3 (GABRB3) and alpha 5 (GABRA5) subunit genes, is located in chromosome 15q11-q13... - Developmental changes in the expression of gamma-aminobutyric acidA/benzodiazepine receptor subunit mRNAs in the murine inferior olivary complexC C Chang
Department of Pharmacology, Ohio State University, Columbus 43210, USA
J Comp Neurol 356:615-28. 1995.... - A novel alpha subunit in rat brain GABAA receptorsM Khrestchatisky
Department of Biology, University of California, Los Angeles 90024
Neuron 3:745-53. 1989..Picrotoxin alone, applied to oocytes producing the alpha and beta polypeptides, elicited an outward current. We suggest that these polypeptides together produce GABA-gated ion channels that can also open spontaneously... - A cluster of three GABAA receptor subunit genes is deleted in a neurological mutant of the mouse p locusY Nakatsu
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
Nature 364:448-50. 1993..The human homologue of the region deleted in p(cp) mice is associated with Angelman syndrome. Thus, p(cp) mice may be useful in defining the region containing the gene(s) for this syndrome... - Molecular analysis of 36 mutations at the mouse pink-eyed dilution (p) locusD K Johnson
Biology Division, Oak Ridge National Laboratory, Tennessee 37831 8077, USA
Genetics 141:1563-71. 1995.... - A microsatellite map of the pink-eyed dilution (p) deletion complex in mouse chromosome 7M S Dhar
University of Tennessee, Graduate School of Biomedical Sciences, Oak Ridge National Laboratory 37831-8077, USA
Mamm Genome 8:143-5. 1997 - Hippocampal alpha5 subunit-containing GABAA receptors modulate the expression of prepulse inhibitionJ Hauser
Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich, CH 8603 Schwerzenbach, Switzerland
Mol Psychiatry 10:201-7. 2005.... - Trace fear conditioning involves hippocampal alpha5 GABA(A) receptorsF Crestani
Institute of Pharmacology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Proc Natl Acad Sci U S A 99:8980-5. 2002..Thus, the largely extrasynaptic alpha5GABA(A) receptors in hippocampal pyramidal cells are implicated as control elements of the temporal association of threat cues in trace fear conditioning... - GABA influences the development of the ventromedial nucleus of the hypothalamusT L Dellovade
Department of Biomedical Sciences, The Shriver Center at UMMS, Waltham, Massachusetts 02452, USA
J Neurobiol 49:264-76. 2001..These data suggest that GABA is important for the organization of cells during VMH formation... - Composition of the GABA(A) receptors of retinal dopaminergic neuronsS Gustincich
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 19:7812-22. 1999..Therefore, DA cells possess at least two types of GABA(A) receptors localized in different synapses. Furthermore, they exhibit multiple extrasynaptic GABA(A) receptors... - Review: Central non-glucocorticoid inhibitors of the hypothalamo-pituitary-adrenal axisD S Jessop
Division of Medicine, Department of Clinical Medicine, University of Bristol, Marlborough Street, Bristol BS2 8HW, UK
J Endocrinol 160:169-80. 1999 - The alpha5 subunit of the murine type A GABA receptorZ F Liu
Department of Pharmacology, University of Maryland School of Medicine, 655 W Baltimore St, Baltimore, MD 21201, USA
Brain Res Mol Brain Res 59:84-9. 1998..Finally, we present preliminary evidence for rare alternative splicing of this subunit's message, in the N-terminal extracellular domain, to give a form not translatable into a functional protein... - Independent assembly and subcellular targeting of GABA(A)-receptor subtypes demonstrated in mouse hippocampal and olfactory neurons in vivoJ M Fritschy
Institute of Pharmacology, University of Zurich, Switzerland
Neurosci Lett 249:99-102. 1998..These findings indicate that the assembly of distinct GABA(A)-receptor subtypes in the same neuron is regulated independently. Furthermore, the alpha-subunit is a prime candidate for providing domains which direct subcellular targeting... - GABAA-receptor alpha-subunit is an essential prerequisite for receptor formation in vivoJ M Fritschy
Institute of Pharmacology, University of Zurich, Switzerland
Neuroscience 81:1043-53. 1997..Thus, the alpha-subunit, unlike the gamma 2-subunit, might play a major role in the assembly or targeting of GABAA-receptor complexes... - Dinucleotide repeat polymorphism at the GABAA receptor alpha 5 (GABRA5) locus at chromosome 15q11-q13K A Glatt
Genetics Division, Children's Hospital, Boston, MA 02115
Hum Mol Genet 1:348. 1992