Genomes and Genes
Gene Symbol: Gabra1
Description: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1
Alias: GABAA-alpha1, GABAAR-alpha1, Gabra-1, gamma-aminobutyric acid receptor subunit alpha-1, GABA(A) receptor subunit alpha-1, GABAA alpha 1, GABAAR alpha1
- Kueh S, Head S, Morley J. GABA(A) receptor expression and inhibitory post-synaptic currents in cerebellar Purkinje cells in dystrophin-deficient mdx mice. Clin Exp Pharmacol Physiol. 2008;35:207-10 pubmed..4. These results may explain some of the behavioural problems and cognitive impairment reported in DMD. ..
- Panzanelli P, Homanics G, Ottersen O, Fritschy J, Sassoè Pognetto M. Pre- and postsynaptic GABA receptors at reciprocal dendrodendritic synapses in the olfactory bulb. Eur J Neurosci. 2004;20:2945-52 pubmed..Such presynaptic receptors may be activated by spillover of GABA from adjacent inhibitory synapses and modulate glutamate release, thereby providing a novel mechanism regulating dendrodendritic inhibition in the olfactory bulb. ..
- Muller E, Triller A, Legendre P. Glycine receptors and GABA receptor alpha 1 and gamma 2 subunits during the development of mouse hypoglossal nucleus. Eur J Neurosci. 2004;20:3286-300 pubmed..A developmental sequence of the postsynaptic events is proposed in which diffuse extrasynaptic GABA(A)Rs accumulate at inhibitory synapses to form postsynaptic clusters, most of them being colocalized with GlyR clusters in the adult. ..
- Bosman L, Heinen K, Spijker S, Brussaard A. Mice lacking the major adult GABAA receptor subtype have normal number of synapses, but retain juvenile IPSC kinetics until adulthood. J Neurophysiol. 2005;94:338-46 pubmed..Hence, they form a good model to study the functional role of developmental GABA(A) receptor subunit switching. ..
- Sonner J, Cascio M, Xing Y, Fanselow M, Kralic J, Morrow A, et al. Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear. Mol Pharmacol. 2005;68:61-8 pubmed..These results indicate that alpha1-containing GABA(A)-Rs in the hippocampus, amygdala, and/or cortex influence the amnestic effects of inhaled anesthetics and may be an important molecular target of the drug isoflurane. ..
- Schneider Gasser E, Duveau V, Prenosil G, Fritschy J. Reorganization of GABAergic circuits maintains GABAA receptor-mediated transmission onto CA1 interneurons in alpha1-subunit-null mice. Eur J Neurosci. 2007;25:3287-304 pubmed..No genotype difference was observed in the effects of kainic acid, indicating that the absence of a major GABA(A) receptor subtype is functionally compensated for in hippocampal interneurons by a reorganization of inhibitory circuits. ..
- Goldstein P, Elsen F, Ying S, Ferguson C, Homanics G, Harrison N. Prolongation of hippocampal miniature inhibitory postsynaptic currents in mice lacking the GABA(A) receptor alpha1 subunit. J Neurophysiol. 2002;88:3208-17 pubmed
- Fritschy J, Panzanelli P, Kralic J, Vogt K, Sassoè Pognetto M. Differential dependence of axo-dendritic and axo-somatic GABAergic synapses on GABAA receptors containing the alpha1 subunit in Purkinje cells. J Neurosci. 2006;26:3245-55 pubmed..In contrast, maintenance of axo-somatic GABAergic synapses does not depend on functional GABAA receptors, suggesting differential regulation in distinct subcellular compartments. ..
- Ogris W, Lehner R, Fuchs K, Furtmuller B, Hoger H, Homanics G, et al. Investigation of the abundance and subunit composition of GABAA receptor subtypes in the cerebellum of alpha1-subunit-deficient mice. J Neurochem. 2006;96:136-47 pubmed..Our results do not support a significant compensatory synthesis of other GABAA receptor subunits in the cerebellum of alpha1 -/- mice. ..
- Kralic J, O Buckley T, Khisti R, Hodge C, Homanics G, Morrow A. GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem. Neuropharmacology. 2002;43:685-94 pubmed..Such adaptations reveal important relationships between subunit expression, receptor function and behavioral responses. ..
- Vicini S, Ferguson C, Prybylowski K, Kralic J, Morrow A, Homanics G. GABA(A) receptor alpha1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons. J Neurosci. 2001;21:3009-16 pubmed..We propose that an increased alpha1 subunit assembly in postsynaptic receptors of cerebellar inhibitory synapses is responsible for the fast inhibitory synaptic currents that are normally observed during postnatal development. ..
- McKernan R, Rosahl T, Reynolds D, Sur C, Wafford K, Atack J, et al. Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype. Nat Neurosci. 2000;3:587-92 pubmed..This finding suggests ways to improve anxiolytics and to develop drugs for other neurological disorders based on their specificity for GABA(A) receptor subtypes in distinct neuronal circuits. ..
- Rudolph U, Crestani F, Benke D, Brünig I, Benson J, Fritschy J, et al. Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature. 1999;401:796-800 pubmed..Thus, benzodiazepine-induced behavioural responses are mediated by specific GABA(A) receptor subtypes in distinct neuronal circuits, which is of interest for drug design. ..
- Briatore F, Patrizi A, Viltono L, Sasso Pognetto M, Wulff P. Quantitative organization of GABAergic synapses in the molecular layer of the mouse cerebellar cortex. PLoS ONE. 2010;5:e12119 pubmed publisher..Based on the pure quantity of GABAergic synapses onto interneurons, we propose that mutual inhibition must play an important, yet largely neglected, computational role in the cerebellar cortex...
- Patrizi A, Scelfo B, Viltono L, Briatore F, Fukaya M, Watanabe M, et al. Synapse formation and clustering of neuroligin-2 in the absence of GABAA receptors. Proc Natl Acad Sci U S A. 2008;105:13151-6 pubmed publisher..However, GABAergic signaling appears to be crucial for activity-dependent regulation of synapse density during neuronal maturation. ..
- Wojcik S, Katsurabayashi S, Guillemin I, Friauf E, Rosenmund C, Brose N, et al. A shared vesicular carrier allows synaptic corelease of GABA and glycine. Neuron. 2006;50:575-87 pubmed..Since GABA and glycine compete for vesicular uptake, these data point to a close association of Viaat with GABA-synthesizing enzymes as a key factor in specifying GABAergic neuronal phenotypes. ..
- Kralic J, Korpi E, O Buckley T, Homanics G, Morrow A. Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice. J Pharmacol Exp Ther. 2002;302:1037-45 pubmed..These data emphasize the significance of alpha1 subunit expression and its involvement in the regulation of CNS excitability. ..
- Keir W, Kozak C, Chakraborti A, Deitrich R, Sikela J. The cDNA sequence and chromosomal location of the murine GABAA alpha 1 receptor gene. Genomics. 1991;9:390-5 pubmed..Excluding deletions, the murine GABAA alpha 1 receptor exhibits 96% nucleotide and 100% amino acid sequence homology to the rat alpha 1 receptor cDNA and ..
- Bosman L, Rosahl T, Brussaard A. Neonatal development of the rat visual cortex: synaptic function of GABAA receptor alpha subunits. J Physiol. 2002;545:169-81 pubmed..Thus, distinct alpha subunit contributions create heterogeneity in developmental acceleration of IPSC decay in neocortex. ..
- Maison S, Rosahl T, Homanics G, Liberman M. Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta. J Neurosci. 2006;26:10315-26 pubmed..Results suggest that the GABAergic component of the olivocochlear system contributes to the long-term maintenance of hair cells and neurons in the inner ear. ..
- Sur C, Wafford K, Reynolds D, Hadingham K, Bromidge F, Macaulay A, et al. Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice. J Neurosci. 2001;21:3409-18 pubmed..Our data confirm that alpha1beta2gamma2 is the major GABA(A) receptor subtype in the murine brain and demonstrate that, surprisingly, the loss of this receptor subtype is not lethal. ..
- Milenkovic I, Vasiljevic M, Maurer D, Hoger H, Klausberger T, Sieghart W. The parvalbumin-positive interneurons in the mouse dentate gyrus express GABAA receptor subunits ?1, ?2, and ? along their extrasynaptic cell membrane. Neuroscience. 2013;254:80-96 pubmed publisher..Our data are important for better understanding of the neuronal circuitries in the DG and the role of specific cell types under pathological conditions. ..
- Swanson A, Allen A, Shapiro L, Gourley S. GABAA?1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection. Neuropsychopharmacology. 2015;40:1027-36 pubmed publisher..Using in vivo viral-mediated gene silencing, we knocked down Gabra1 in the orbitofrontal prefrontal cortex (oPFC) in mice, decreasing oPFC GABAA?1 expression, as well as expression ..
- Seo S, Leitch B. Altered thalamic GABAA-receptor subunit expression in the stargazer mouse model of absence epilepsy. Epilepsia. 2014;55:224-32 pubmed publisher..Ultimately, this information could be crucial for the development of more specific and effective therapeutic drugs for treatment of this form of epilepsy. ..
- Hood H, Metten P, Crabbe J, Buck K. Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11. Genes Brain Behav. 2006;5:1-10 pubmed
- Tyagi N, Moshal K, Tyagi S, Lominadze D. gamma-Aminbuturic acid A receptor mitigates homocysteine-induced endothelial cell permeability. Endothelium. 2007;14:315-23 pubmed..The data suggest that Hcy increases EC layer permeability through inhibition of GABA(A) receptor and F-actin formation, in part, by transducing ERK and MMP-9 activation. ..
- Temple J, Wray S. Developmental changes in GABA receptor subunit composition within the gonadotrophin-releasing hormone-1 neuronal system. J Neuroendocrinol. 2005;17:591-9 pubmed..5 to adulthood, as well as in nasal explants. We show that GABAAalpha2 and alpha6 are present in the GnRH-1 neuronal system both in vivo and in vitro and that the levels of expression are altered as a function of age. ..
- Lin W, Tsai M, Davenport C, Smith C, Veit J, Wilson N, et al. A Comprehensive Optogenetic Pharmacology Toolkit for In Vivo Control of GABA(A) Receptors and Synaptic Inhibition. Neuron. 2015;88:879-891 pubmed publisher..This optogenetic pharmacology toolkit allows scalable interrogation of endogenous GABA(A) receptor function with high spatial, temporal, and biochemical precision. ..
- Kralic J, Criswell H, Osterman J, O Buckley T, Wilkie M, Matthews D, et al. Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice. J Clin Invest. 2005;115:774-9 pubmed..This genetic animal model elucidates a mechanism of GABAergic dysfunction in the major motor pathway and potential targets for pharmacotherapy of essential tremor. ..
- Ponomarev I, Maiya R, Harnett M, Schafer G, Ryabinin A, Blednov Y, et al. Transcriptional signatures of cellular plasticity in mice lacking the alpha1 subunit of GABAA receptors. J Neurosci. 2006;26:5673-83 pubmed
- Ortinski P, Turner J, Barberis A, Motamedi G, Yasuda R, Wolfe B, et al. Deletion of the GABA(A) receptor alpha1 subunit increases tonic GABA(A) receptor current: a role for GABA uptake transporters. J Neurosci. 2006;26:9323-31 pubmed
- Houston C, Lee H, Hosie A, Moss S, Smart T. Identification of the sites for CaMK-II-dependent phosphorylation of GABA(A) receptors. J Biol Chem. 2007;282:17855-65 pubmed..These findings were confirmed in a neuronal environment by expressing recombinant GABA(A) receptors in cerebellar granule neurons. ..
- Wang J, Liu S, Haditsch U, Tu W, Cochrane K, Ahmadian G, et al. Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapses. J Neurosci. 2003;23:826-36 pubmed..Thus, an activity-dependent physical and functional interaction between CaN and GABA(A) receptors is both necessary and sufficient for inducing LTD at CA1 individual inhibitory synapses. ..
- Elsen F, Liljelund P, Werner D, Olsen R, Homanics G, Harrison N. GABA(A)-R alpha1 subunit knockin mutation leads to abnormal EEG and anesthetic-induced seizure-like activity in mice. Brain Res. 2006;1078:60-70 pubmed
- Gill K, Boyle A. Genetic basis for the psychostimulant effects of nicotine: a quantitative trait locus analysis in AcB/BcA recombinant congenic mice. Genes Brain Behav. 2005;4:401-11 pubmed..A number of putative candidate genes were in proximity to regions identified with nicotine sensitivity, including the alpha2 subunit of the nicotinic acetylcholine receptor and the dopamine D3 receptor...
- Benke D, Fakitsas P, Roggenmoser C, Michel C, Rudolph U, Mohler H. Analysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunits. J Biol Chem. 2004;279:43654-60 pubmed..This experimental approach provides the basis for a detailed analysis of the abundance of GABAA receptors containing heterologous alpha subunits on a brain regional level. ..
- Hales T, Deeb T, Tang H, Bollan K, King D, Johnson S, et al. An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunits. J Biol Chem. 2006;281:17034-43 pubmed..Moreover, the conserved TM2-3 loop lysine has an asymmetric function in different GABAA subunits. ..
- Chang K, Park Y, Park H, Homanics G, Kim J, Kim D. Lack of CaV3.1 channels causes severe motor coordination defects and an age-dependent cerebellar atrophy in a genetic model of essential tremor. Biochem Biophys Res Commun. 2011;410:19-23 pubmed publisher..These results suggest that ?1(-/-)/?(1G)(-/-) mice are a novel mouse model for a distinct subtype of ET in human and that Ca(V)3.1 T-type Ca(2+) channels play a role in motor coordination under pathological conditions. ..
- Lagier S, Panzanelli P, RUSSO R, Nissant A, Bathellier B, Sassoè Pognetto M, et al. GABAergic inhibition at dendrodendritic synapses tunes gamma oscillations in the olfactory bulb. Proc Natl Acad Sci U S A. 2007;104:7259-64 pubmed..We conclude, therefore, that fast oscillations in the OB circuit are strongly constrained by the precise location, subunit composition and kinetics of GABA(A) receptors expressed in mitral cells. ..
- Kalcheva I, Plass C, Sait S, Eddy R, Shows T, Watkins Chow D, et al. Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5. Cytogenet Cell Genet. 1995;68:19-24 pubmed..The location of the human homologue has been determined using both somatic cell hybrid genetic analysis and fluorescence in situ hybridization. These analyses have mapped the human locus U2AFBPL to human chromosome 5q23-->q31. ..
- Wang J, Kofuji P, Fernando J, Moss S, Huganir R, Burt D. The alpha 1, alpha 2, and alpha 3 subunits of GABAA receptors: comparison in seizure-prone and -resistant mice and during development. J Mol Neurosci. 1992;3:177-84 pubmed
- Kato K. A Collection of cDNA Clones with Specific Expression Patterns in Mouse Brain. Eur J Neurosci. 1990;2:704-711 pubmed..Among them seven clones were especially abundant in specific nuclei, and three in specific fibre bundles. These clones will be useful in defining new subpopulations of brain cells characterized by different gene expression. ..
- Jessop D. Review: Central non-glucocorticoid inhibitors of the hypothalamo-pituitary-adrenal axis. J Endocrinol. 1999;160:169-80 pubmed
- Balic E, Rudolph U, Fritschy J, Mohler H, Benke D. The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing two distinct types of alpha subunits. J Neurochem. 2009;110:244-54 pubmed publisher..These findings imply an important role of histidine 105 in determining the position of the alpha5 subunit within the receptor complex by determining the affinity for assembly with the gamma2 subunit. ..
- Abramian A, Comenencia Ortiz E, Vithlani M, Tretter E, Sieghart W, Davies P, et al. Protein kinase C phosphorylation regulates membrane insertion of GABAA receptor subtypes that mediate tonic inhibition. J Biol Chem. 2010;285:41795-805 pubmed publisher..These results suggest that PKC-dependent phosphorylation of the ?4 subunit plays a significant role in enhancing the cell surface stability and activity of GABA(A)R subtypes that mediate tonic inhibition. ..
- Manceau V, Kremmer E, Nabel E, Maucuer A. The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice. PLoS ONE. 2012;7:e43946 pubmed publisher..This difference suggests that disregulation of gene expression due to KIS inactivation affects specific brain functions. ..
- Kozak C, Danciger M, Bowes C, Adamson M, Palczewski K, Polans A, et al. Localization of three genes expressed in retina on mouse chromosome 11. Mamm Genome. 1995;6:142-4 pubmed
- Corteen N, Carter J, Rudolph U, Belelli D, Lambert J, Swinny J. Localisation and stress-induced plasticity of GABAA receptor subunits within the cellular networks of the mouse dorsal raphe nucleus. Brain Struct Funct. 2015;220:2739-63 pubmed publisher..Only a topographically located sub-population of serotonergic neurons exhibited GABAAR alpha1 subunit immunoreactivity...
- Arain F, Zhou C, Ding L, Zaidi S, Gallagher M. The developmental evolution of the seizure phenotype and cortical inhibition in mouse models of juvenile myoclonic epilepsy. Neurobiol Dis. 2015;82:164-175 pubmed publisher..However, developmental changes in M1 GABA(A)Rs do not explain the worsened phenotype at P120 in mutant mice. ..
- Shen H, Gong Q, Aoki C, Yuan M, Ruderman Y, Dattilo M, et al. Reversal of neurosteroid effects at alpha4beta2delta GABAA receptors triggers anxiety at puberty. Nat Neurosci. 2007;10:469-77 pubmed..Therefore, inhibition of alpha4beta2delta GABAA receptors by THP provides a mechanism for the generation of anxiety at puberty. ..
- Andäng M, Hjerling Leffler J, Moliner A, Lundgren T, Castelo Branco G, Nanou E, et al. Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation. Nature. 2008;451:460-4 pubmed publisher..These results indicate the presence of a fundamentally different mechanism of proliferation control in these stem cells, in comparison with most somatic cells, involving proteins in the DNA damage checkpoint pathway. ..
- Heistek T, Ruiperez Alonso M, Timmerman A, Brussaard A, Mansvelder H. ?2-containing GABAA receptors expressed in hippocampal region CA3 control fast network oscillations. J Physiol. 2013;591:845-58 pubmed publisher..These findings suggest that ?2-containing GABA(A) receptors expressed in the CA3 region provide the inhibition that controls hippocampal rhythm during cholinergically induced oscillations. ..
- Ghafari M, Falsafi S, Szodorai E, Kim E, Li L, Hoger H, et al. Formation of GABAA receptor complexes containing ?1 and ?5 subunits is paralleling a multiple T-maze learning task in mice. Brain Struct Funct. 2017;222:549-561 pubmed publisher..Taken together, these results suggest that ?1, ?5 and ?2-containing hippocampal GABAAR complexes play an essential role in spatial learning and memory in which targeted disruption of the ?1 subunit produces profound deficits. ..
- Picard N, Guénin S, Perrin Y, Hilaire G, Larnicol N. Consequences of prenatal exposure to diazepam on the respiratory parameters, respiratory network activity and gene expression of alpha1 and alpha2 subunits of GABA(A) receptor in newborn rat. Adv Exp Med Biol. 2008;605:144-8 pubmed..On the other hand, the effects of DZP exposure on reduced preparations suggested changes in the GABA(A) receptor efficiency and/or disruption of the normal development of the medullary respiratory network. ..
- Antflick J, Hampson D. Modulation of glutamate release from parallel fibers by mGlu4 and pre-synaptic GABA(A) receptors. J Neurochem. 2012;120:552-63 pubmed publisher..Taken together, our data suggest a new role for mGlu4 whereby simultaneous activation with GABA(A) receptors acts to amplify glutamate release at parallel fiber-Purkinje cell synapses. ..
- Spicer A, Roller M, Camper S, McPherson J, Wasmuth J, Hakim S, et al. The human and mouse receptors for hyaluronan-mediated motility, RHAMM, genes (HMMR) map to human chromosome 5q33.2-qter and mouse chromosome 11. Genomics. 1995;30:115-7 pubmed..The RHAMM gene location and its ability to transform cells when overexpressed implicate RHAMM as a possible candidate gene in the pathogenesis of the recently described t(5;14)(q33-q34;q11) acute lymphoblastic leukemias. ..
- Cesetti T, Fila T, Obernier K, Bengtson C, Li Y, Mandl C, et al. GABAA receptor signaling induces osmotic swelling and cell cycle activation of neonatal prominin+ precursors. Stem Cells. 2011;29:307-19 pubmed publisher..Our results also have potential implications for the therapeutic practices that involve exposure to GABA(A) Rs modulators during neurodevelopment. ..
- Chen X, Whissell P, Orser B, MacDonald J. Functional modifications of acid-sensing ion channels by ligand-gated chloride channels. PLoS ONE. 2011;6:e21970 pubmed publisher..We conclude that GABA(A) receptors and glycine receptors modify ASICs in neurons through mechanisms that require the opening of chloride channels. ..
- Feng Y, He X, Yang Y, Chen J, Yin K, Xia Y. Effect of delta-opioid receptor over-expression on cortical expression of GABAA receptor alpha1-subunit in hypoxia. Chin J Physiol. 2011;54:118-23 pubmed..Since DOR over-expression increases cortical tolerance to hypoxia, an increase in GABA receptors expression (an energy-costing process) may not be necessary in the cortex with DOR over-expression. ..
- Zahniser N, Buck K, Curella P, McQuilkin S, Wilson Shaw D, Miller C, et al. GABAA receptor function and regional analysis of subunit mRNAs in long-sleep and short-sleep mouse brain. Brain Res Mol Brain Res. 1992;14:196-206 pubmed
- Arain F, Boyd K, Gallagher M. Decreased viability and absence-like epilepsy in mice lacking or deficient in the GABAA receptor ?1 subunit. Epilepsia. 2012;53:e161-5 pubmed publisher..These findings suggest that ?1 subunit haploinsufficiency can produce epilepsy and may be a major mechanism by which the S326fs328X and A322D mutations cause these epilepsy syndromes. ..
- Ralvenius W, Benke D, AcuÃ±a M, Rudolph U, Zeilhofer H. Analgesia and unwanted benzodiazepine effects in point-mutated mice expressing only one benzodiazepine-sensitive GABAA receptor subtype. Nat Commun. 2015;6:6803 pubmed publisher..These findings should foster the development of innovative subtype-selective BDZs for novel indications such as chronic pain. ..
- Aguado F, Díaz Ruiz C, Parlato R, MARTINEZ A, Carmona M, Bleckmann S, et al. The CREB/CREM transcription factors negatively regulate early synaptogenesis and spontaneous network activity. J Neurosci. 2009;29:328-33 pubmed publisher..Thus, the functions of CREB/CREM genes in neural activity differ in distinct periods of neural development. ..
- Herd M, Haythornthwaite A, Rosahl T, Wafford K, Homanics G, Lambert J, et al. The expression of GABAA beta subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells. J Physiol. 2008;586:989-1004 pubmed..The unambiguous identification of these distinct pools of synaptic and extrasynaptic GABA(A) receptors should aid our understanding of how they act in harmony, to regulate hippocampal signalling in health and disease. ..
- Baptista Hon D, Gulbinaite S, Hales T. Loop G in the GABAA receptor Î±1 subunit influences gating efficacy. J Physiol. 2017;595:1725-1741 pubmed publisher..Immobilisation of the Î²1 strand may provide a mechanism for the inhibition of gating by inverse agonists such as bicuculline. ..
- Prenosil G, Schneider Gasser E, Rudolph U, Keist R, Fritschy J, Vogt K. Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons. J Neurophysiol. 2006;96:846-57 pubmed..These results show that the major forms of inhibitory neurotransmission in hippocampal pyramidal cells are mediated by distinct GABA(A)Rs subtypes...
- Telegdy G, Schally A. Involvement of neurotransmitters in the action of growth hormone-releasing hormone antagonist on passive avoidance learning. Behav Brain Res. 2012;233:326-30 pubmed publisher..The results demonstrate that the muscarinic acetylcholine receptor, the 5-HT1/5-HT2 serotonergic receptor and opioid receptors are involved as mediators in the action of MZ-4-71 on the consolidation of passive avoidance learning. ..
- Reynolds D, O Meara G, Newman R, Bromidge F, Atack J, Whiting P, et al. GABA(A) alpha 1 subunit knock-out mice do not show a hyperlocomotor response following amphetamine or cocaine treatment. Neuropharmacology. 2003;44:190-8 pubmed..These data demonstrate subtle changes in behaviours mediated by neurotransmitters other than GABA in alpha1 KO mice and suggest that compensation may have occurred beyond the GABAergic system. ..
- Ben Zur T, Wides R. Mapping homologs of Drosophila odd Oz (odz): Doc4/Odz4 to mouse chromosome 7, Odz1 to mouse chromosome 11; and ODZ3 to human chromosome Xq25. Genomics. 1999;58:102-3 pubmed
- Turecek J, Jackman S, Regehr W. Synaptic Specializations Support Frequency-Independent Purkinje Cell Output from the Cerebellar Cortex. Cell Rep. 2016;17:3256-3268 pubmed publisher..Short-term facilitation offsets partial vesicle depletion to produce frequency-independent transmission. ..
- Buckwalter M, Lossie A, Scarlett L, Camper S. Localization of the human chromosome 5q genes Gabra-1, Gabrg-2, Il-4, Il-5, and Irf-1 on mouse chromosome 11. Mamm Genome. 1992;3:604-7 pubmed
- Ives J, Drewery D, Thompson C. Differential cell surface expression of GABAA receptor alpha1, alpha6, beta2 and beta3 subunits in cultured mouse cerebellar granule cells influence of cAMP-activated signalling. J Neurochem. 2002;80:317-27 pubmed..The intracellular pool of alpha6 was not affected. Thus, GABAR subunits are subject to differentially regulated trafficking, affording yet greater scope for GABAR diversity and plasticity. ..
- Uusi Oukari M, Heikkila J, Sinkkonen S, Mäkelä R, Hauer B, Homanics G, et al. Long-range interactions in neuronal gene expression: evidence from gene targeting in the GABA(A) receptor beta2-alpha6-alpha1-gamma2 subunit gene cluster. Mol Cell Neurosci. 2000;16:34-41 pubmed..The data suggest that elements in the neo gene may have an influence over long distances in the GABA(A) subunit gene complex on as yet undefined structures coordinating the expression of the alpha1 and beta2 genes. ..
- Fagiolini M, Fritschy J, Löw K, Mohler H, Rudolph U, Hensch T. Specific GABAA circuits for visual cortical plasticity. Science. 2004;303:1681-3 pubmed..This dissociation carries implications for models of brain development and the safe design of benzodiazepines for use in infants. ..
- Takayama C, Inoue Y. Morphological development and maturation of the GABAergic synapses in the mouse cerebellar granular layer. Brain Res Dev Brain Res. 2004;150:177-90 pubmed..Furthermore, it was suggested that GABAergic innervation could initiate expression and trafficking of the GABA(A) receptors containing the alpha1 and alpha6 subunits. ..
- Zhou C, Ding L, Deel M, Ferrick E, Emeson R, Gallagher M. Altered intrathalamic GABAA neurotransmission in a mouse model of a human genetic absence epilepsy syndrome. Neurobiol Dis. 2015;73:407-17 pubmed publisherWe previously demonstrated that heterozygous deletion of Gabra1, the mouse homolog of the human absence epilepsy gene that encodes the GABAA receptor (GABAAR) ?1 subunit, causes absence seizures...
- Lappe Siefke C, Loebrich S, Hevers W, Waidmann O, Schweizer M, Fehr S, et al. The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice. PLoS Genet. 2009;5:e1000631 pubmed publisher..Although other currently unknown changes might be involved, our data show that ubiquitin-dependent GABA(A)R turnover at cerebellar synapses contributes to ax(J)-mediated behavioural impairment...
- Mizokami A, Tanaka H, Ishibashi H, Umebayashi H, Fukami K, Takenawa T, et al. GABA(A) receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice. J Neurochem. 2010;114:302-10 pubmed publisher..PRIP-1 and 2 double KO mice exhibit a diazepam-insensitive phenotype because of a decrease in diazepam-sensitive (alpha1/gamma2) and increase in diazepam-insensitive (alpha6/gamma2) GABA(A) receptors in the cerebellar granule cells. ..
- Tanabe Y, Naito Y, Vasuta C, Lee A, Soumounou Y, Linhoff M, et al. IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2?. Nat Commun. 2017;8:408 pubmed publisher..Here the authors show that IgSF21 interacts with neurexin2? to induce presynaptic differentiation of inhibitory synapses, and that mice lacking IgSF21 exhibit deficits in inhibitory synaptic transmission. ..
- Vaknin U, Hann S. The alpha1 subunit of GABAA receptor is repressed by c-myc and is pro-apoptotic. J Cell Biochem. 2006;97:1094-103 pubmed..In addition, the regulation of GABAAR-alpha1 expression by c-myc provides a potential direct role for the Myc proteins in neurological processes and neurodegenerative disorders. ..
- Di X, Wang Y, Han D, Fu Y, Duerfeldt A, Blagg B, et al. Grp94 Protein Delivers Î³-Aminobutyric Acid Type A (GABAA) Receptors to Hrd1 Protein-mediated Endoplasmic Reticulum-associated Degradation. J Biol Chem. 2016;291:9526-39 pubmed publisher..This study clarifies a Grp94-mediated ERAD pathway for GABAA receptors, which provides a novel way to finely tune their function in physiological and pathophysiological conditions. ..
- Ravindran C, Ticku M. Tyrosine kinase phosphorylation of GABA(A) receptor alpha1, beta2 and gamma2 subunits following chronic intermittent ethanol (CIE) exposure of cultured cortical neurons of mice. Neurochem Res. 2006;31:1111-8 pubmed..In conclusion, the CIE exposure, unlike chronic/acute ethanol exposure, regulates the tyrosine kinase phosphorylation of the selective population of GABA(A )receptors in a long lasting manner. ..
- Davies R, Roberts A, Morris A, Griffith G, Jerecic J, Ghandi S, et al. Enhanced access to rare brain cDNAs by prescreening libraries: 207 new mouse brain ESTs. Genomics. 1994;24:456-63 pubmed..In total, the comparative sequencing experiments generated 207 new mouse and 11 new rat brain ESTs. ..