G6pdx

Summary

Gene Symbol: G6pdx
Description: glucose-6-phosphate dehydrogenase X-linked
Alias: G28A, G6pd, Gpdx, glucose-6-phosphate 1-dehydrogenase X
Species: mouse
Products:     G6pdx

Top Publications

  1. Hecker P, Mapanga R, Kimar C, Ribeiro R, Brown B, O Connell K, et al. Effects of glucose-6-phosphate dehydrogenase deficiency on the metabolic and cardiac responses to obesogenic or high-fructose diets. Am J Physiol Endocrinol Metab. 2012;303:E959-72 pubmed publisher
    ..WT and G6PD-deficient (G6PDX) mice received a standard high-starch diet, a high-fat/high-sucrose diet to induce obesity (DIO), or a high-..
  2. Bergsagel P, Timblin C, Eckhardt L, Laskov R, Kuehl W. Sequence and expression of a murine cDNA encoding PC326, a novel gene expressed in plasmacytomas but not normal plasma cells. Oncogene. 1992;7:2059-64 pubmed
    ..Since PC326 is not expressed in normal plasma cells, it appears that its expression is a cause or consequence of the tumorigenic process that generates murine plasmacytomas. ..
  3. White R, McNulty S, Roman S, Garg U, Wirtz E, Kohlbrecher D, et al. Chromosomal localization, hematologic characterization, and iron metabolism of the hereditary erythroblastic anemia (hea) mutant mouse. Blood. 2004;104:1511-8 pubmed
    ..When this diet is removed there is reversion to anemia with concomitant loss of overloaded iron stores. We speculate that the hea/fsn gene is required for iron uptake into erythropoietic cells and for kidney iron reabsorption. ..
  4. Rivella S, Tamanini F, Bione S, Mancini M, Herman G, Chatterjee A, et al. A comparative transcriptional map of a region of 250 kb on the human and mouse X chromosome between the G6PD and the FLN1 genes. Genomics. 1995;28:377-82 pubmed
    The transcriptional organization of the region of the mouse X chromosome between the G6pd and the Fln1 genes was studied in detail, and it was compared with the syntenic region of the human chromosome...
  5. Matsui R, Xu S, Maitland K, Hayes A, Leopold J, Handy D, et al. Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II. Circulation. 2005;112:257-63 pubmed
    Glucose-6-phosphate dehydrogenase (G6PD) regulates production of the reduced form of NADPH through the pentose phosphate pathway...
  6. Savarese F, Flahndorfer K, Jaenisch R, Busslinger M, Wutz A. Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation. Mol Cell Biol. 2006;26:7167-77 pubmed
    ..This suggests that Xist function is restricted in development by the limited activity of epigenetic pathways rather than by a change in the responsiveness of chromatin between embryonic and differentiated cell types. ..
  7. Filippi M, Tribioli C, Toniolo D. Linkage and sequence conservation of the X-linked genes DXS253E (P3) and DXS254E (GdX) in mouse and man. Genomics. 1990;7:453-7 pubmed
    ..The CpG island corresponds to that at the 5' of the human GdX gene. The relative orientation of the two genes is the same. The DNA sequence in coding and noncoding regions is very conserved. ..
  8. Frattini A, Chatterjee A, Faranda S, Sacco M, Villa A, Herman G, et al. The chromosome localization and the HCF repeats of the human host cell factor gene (HCFC1) are conserved in the mouse homologue. Genomics. 1996;32:277-80 pubmed
    ..The mouse HCFC1 gene maps to a region syntenic to Xq28, and, as in human, is in close proximity to the Renin-binding protein gene, in a 100-kb region also including the Licam and Vasopressin receptor type 2 genes. ..
  9. Amakawa Y, Sakata Y, Hoki Y, Arata S, Shioda S, Fukagawa T, et al. A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects. Development. 2015;142:4299-308 pubmed publisher
    ..This might underlie the mechanism for the maternal repression of Xist at the early cleavage stage when Tsix expression has not yet occurred on Xm. ..

More Information

Publications81

  1. Mejias R, Villadiego J, Pintado C, Vime P, Gao L, Toledo Aral J, et al. Neuroprotection by transgenic expression of glucose-6-phosphate dehydrogenase in dopaminergic nigrostriatal neurons of mice. J Neurosci. 2006;26:4500-8 pubmed
    ..Glucose-6-phosphate dehydrogenase (G6PD) is a key cytoprotective enzyme that provides NADPH, the major source of the reducing equivalents of a cell...
  2. Paglialunga F, Fico A, Iaccarino I, Notaro R, Luzzatto L, Martini G, et al. G6PD is indispensable for erythropoiesis after the embryonic-adult hemoglobin switch. Blood. 2004;104:3148-52 pubmed
    Glucose 6-phosphate dehydrogenase (G6PD) (EC 1.1.1.42) is an essential enzyme for the rapid production of NADPH, as required on exposure to oxidative stress...
  3. De Schepper G, Vander Perk C, Westerveld A, Oosting J, Van Noorden C. In situ glucose-6-phosphate dehydrogenase activity during development of pre-implantation mouse embryos. Histochem J. 1993;25:299-303 pubmed
    ..It is concluded that high activity of glucose-6-phosphate dehydrogenase in oocytes is needed for keeping oocytes viable, and for generation of NADPH which is important for the fertilization process. ..
  4. Rawat D, Hecker P, Watanabe M, Chettimada S, Levy R, Okada T, et al. Glucose-6-phosphate dehydrogenase and NADPH redox regulates cardiac myocyte L-type calcium channel activity and myocardial contractile function. PLoS ONE. 2012;7:e45365 pubmed publisher
    ..Because 17-ketosteroids are known to inhibit glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway, and to reduce intracellular NADPH levels, we ..
  5. Ruddle F, Roderick T. Allelically-determined isozyme polymorphisms in laboratory populations of mice. Ann N Y Acad Sci. 1968;151:531-9 pubmed
  6. Hutton J, Roderick T. Linkage analyses using biochemical variants in mice. 3. Linkage relationships of eleven biochemical markers. Biochem Genet. 1970;4:339-50 pubmed
  7. Lyon M, Peters J, Glenister P, Ball S, Wright E. The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome. Proc Natl Acad Sci U S A. 1990;87:2433-7 pubmed
    ..Scurfy differs from Wiskott-Aldrich syndrome in that scurfy males are consistently hypogonadal. ..
  8. Chapman V, Keitz B, Stephenson D, Mullins L, Moos M, Schachner M. Linkage of a gene for neural cell adhesion molecule, L1 (CamL1) to the Rsvp region of the mouse X chromosome. Genomics. 1990;8:113-8 pubmed
    ..The X chromosome linkage and the relative position on the X chromosome coincident with the genes Rsvp/G6pd/Cf-8 were defined in backcross matings involving M. spretus and M. musculus.
  9. Nicol C, Zielenski J, Tsui L, Wells P. An embryoprotective role for glucose-6-phosphate dehydrogenase in developmental oxidative stress and chemical teratogenesis. FASEB J. 2000;14:111-27 pubmed
    The primary recognized health risk from common deficiencies in glucose-6-phosphate dehydrogenase (G6PD), a cytoprotective enzyme for oxidative stress, is red blood cell hemolysis...
  10. Chapman V, Shows T. Somatic cell genetic evidence for X-chromosome linkage of three enzymes in the mouse. Nature. 1976;259:665-7 pubmed
  11. Kuraguchi M, Thomas G, Williams E. Somatic mutation of the glucose-6-phosphate dehydrogenase (g6pd) gene in colonic stem cells and crypt restricted loss of G6PD activity. Mutat Res. 1997;379:69-75 pubmed
    ..The present study identifies and characterises somatic mutations in the g6pd gene in individual mouse colonic crypts showing histochemically demonstrable loss of G6PD activity...
  12. Felix K, Rockwood L, Pretsch W, Nair J, Bartsch H, Bornkamm G, et al. Moderate G6PD deficiency increases mutation rates in the brain of mice. Free Radic Biol Med. 2002;32:663-73 pubmed
    ..the x-ray-induced low efficiency allele of the major X-linked isozyme of glucose-6-phospate dehydrogenase (G6PD), Gpdx(a-m2Neu), and, in addition, harbored the transgenic shuttle vector for the determination of mutagenesis in vivo, ..
  13. Heilig R, Lemaire C, Mandel J, Dandolo L, Amar L, Avner P. Localization of the region homologous to the Duchenne muscular dystrophy locus on the mouse X chromosome. Nature. 1987;328:168-70 pubmed
    ..By analogy with the human X-chromosome, we conclude that the region in the mouse around the G6pd and St14-1 loci may contain two genes corresponding to distinct human myopathies: Emery Dreifuss muscular dystrophy ..
  14. Leopold J, Walker J, Scribner A, Voetsch B, Zhang Y, Loscalzo A, et al. Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis. J Biol Chem. 2003;278:32100-6 pubmed
    Glucose-6-phosphate dehydrogenase (G6PD), the first enzyme of the pentose phosphate pathway, is the principal intracellular source of NADPH...
  15. Hendriksen P, Hoogerbrugge J, Baarends W, de Boer P, Vreeburg J, Vos E, et al. Testis-specific expression of a functional retroposon encoding glucose-6-phosphate dehydrogenase in the mouse. Genomics. 1997;41:350-9 pubmed
    The X-chromosomal gene glucose-6-phosphate dehydrogenase (G6pd) is known to be expressed in most cell types of mammalian species. In the mouse, we have detected a novel gene, designated G6pd-2, encoding a G6PD isoenzyme...
  16. Epstein C. Mammalian oocytes: X chromosome activity. Science. 1969;163:1078-9 pubmed
  17. Chamberlain J, Grant S, Reeves A, Mullins L, Stephenson D, Hoffman E, et al. Regional localization of the murine Duchenne muscular dystrophy gene on the mouse X chromosome. Somat Cell Mol Genet. 1987;13:671-8 pubmed
    ..However, Southern analysis of portions of the mouse Dmd gene has not yet revealed any differences between mdx and wild-type mice. ..
  18. Cavanna J, Coulton G, Morgan J, Brockdorff N, Forrest S, Davies K, et al. Molecular and genetic mapping of the mouse mdx locus. Genomics. 1988;3:337-41 pubmed
    ..These genetic data support the contention from biochemical studies (E.P. Hoffman, R. H. Brown, and L. M. Kunkel, 1987, Cell 51: 919-928) that DMD and mdx are homologous genes. ..
  19. Avner P, Amar L, Arnaud D, Hanauer A, Cambrou J. Detailed ordering of markers localizing to the Xq26-Xqter region of the human X chromosome by the use of an interspecific Mus spretus mouse cross. Proc Natl Acad Sci U S A. 1987;84:1629-33 pubmed
    ..Pedigree and recombinational analysis establish the marker order as being Hprt-FIX-c11-G6PD-St14-1...
  20. Alcalay M, Toniolo D. CpG islands of the X chromosome are gene associated. Nucleic Acids Res. 1988;16:9527-43 pubmed
    ..We have identified a CpG island in the 5' region of the G6PD gene, and two islands forty Kb 3' from the G6PD gene, on the human X chromosome...
  21. Pandolfi P, Sonati F, Rivi R, Mason P, Grosveld F, Luzzatto L. Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress. EMBO J. 1995;14:5209-15 pubmed
    Glucose 6-phosphate dehydrogenase (G6PD) is a housekeeping enzyme encoded in mammals by an X-linked gene...
  22. Gregory M, D Alessandro A, Alvarez Calderon F, Kim J, Nemkov T, Adane B, et al. ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia. Proc Natl Acad Sci U S A. 2016;113:E6669-E6678 pubmed
    ..We found that inactivating ATM or its downstream effector glucose 6-phosphate dehydrogenase (G6PD) sensitizes AML cells to FLT3 inhibitor induced apoptosis...
  23. Martin DeLeon P, Wolf S, Persico G, Toniolo D, Martini G, Migeon B. Localization of glucose-6-phosphate dehydrogenase in mouse and man by in situ hybridization: evidence for a single locus and transposition of homologous X-linked genes. Cytogenet Cell Genet. 1985;39:87-92 pubmed
    ..probe (pGD3) to metaphase chromosomes in situ, we have localized the gene for glucose-6-phosphate dehydrogenase (G6PD) in both the human and mouse complement...
  24. Amar L, Dandolo L, Hanauer A, Cook A, Arnaud D, Mandel J, et al. Conservation and reorganization of loci on the mammalian X chromosome: a molecular framework for the identification of homologous subchromosomal regions in man and mouse. Genomics. 1988;2:220-30 pubmed
  25. Jung E, Hong Y, Kim J, Park Y, Bae S, Chang U, et al. Effects of yeast hydrolysate on hepatic lipid metabolism in high-fat-diet-induced obese mice: yeast hydrolysate suppresses body fat accumulation by attenuating fatty acid synthesis. Ann Nutr Metab. 2012;61:89-94 pubmed
    ..05). Hepatic glucose-6-phosphate dehydrogenase (G6PD) activity was inhibited by YH supplementation compared with the HF group, and mice treated orally with 1% YH ..
  26. Wang Q, Latham K. Requirement for protein synthesis during embryonic genome activation in mice. Mol Reprod Dev. 1997;47:265-70 pubmed
  27. Khan A, Zong Chao L, Efendic S, Landau B. Glucose-6-phosphatase activity in the hypothalamus of the ob/ob mouse. Metabolism. 1998;47:627-9 pubmed
    ..However, obese gene product administration to ob/ob mice, while reducing the body weight, did not alter the glucose-6-phosphatase activity...
  28. Andalibi A, Diep A, Quon D, Mohandas T, Taylor B, Lusis A. Mapping of multiple mouse loci related to the farnesyl pyrophosphate synthetase gene. Mamm Genome. 1993;4:211-9 pubmed
    ..It is presently unclear which of these loci encode active prenyltransferases and which may correspond to pseudogenes. The strongly hybridizing loci provide convenient genetic markers for seven mouse chromosomes. ..
  29. Nóbrega Pereira S, Fernandez Marcos P, Brioche T, Gomez Cabrera M, Salvador Pascual A, Flores J, et al. G6PD protects from oxidative damage and improves healthspan in mice. Nat Commun. 2016;7:10894 pubmed publisher
    ..the reductive power of NAPDH, whose levels are mostly determined by the enzyme glucose-6-phosphate dehydrogenase (G6PD). Here, we report a transgenic mouse model with moderate overexpression of human G6PD under its endogenous promoter...
  30. Peters J, Ball S, Charles D, Pretsch W, Bulfield G, Miller D, et al. The localization of G6pd, glucose-6-phosphate dehydrogenase, and mdx, muscular dystrophy in the mouse X chromosome. Genet Res. 1988;52:195-201 pubmed
  31. Mullins L, Grant S, Stephenson D, Chapman V. Multilocus molecular mapping of the mouse X chromosome. Genomics. 1988;3:187-94 pubmed
    ..coagulation factor VIII), and Rsvp (red-sensitive visual pigment) and the known X-linked markers Otc, Hprt, Cf-9, G6pd, and Ags...
  32. Longo L, Vanegas O, Patel M, Rosti V, Li H, Waka J, et al. Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal. EMBO J. 2002;21:4229-39 pubmed
    Mouse chimeras from embryonic stem cells in which the X-linked glucose 6-phosphate dehydrogenase (G6PD) gene had been targeted were crossed with normal females...
  33. Gariboldi M, Maestrini E, Canzian F, Manenti G, De Gregorio L, Rivella S, et al. Comparative mapping of the actin-binding protein 280 genes in human and mouse. Genomics. 1994;21:428-30 pubmed
  34. Xu Y, Zhang Z, Hu J, Stillman I, Leopold J, Handy D, et al. Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria. FASEB J. 2010;24:609-16 pubmed publisher
    Glucose-6-phosphate dehydrogenase (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway and the principal source of NADPH, a major cellular reductant, and is central to cell survival...
  35. Sanders S, Smith D, Thomas G, Williams E. A glucose-6-phosphate dehydrogenase (G6PD) splice site consensus sequence mutation associated with G6PD enzyme deficiency. Mutat Res. 1997;374:79-87 pubmed
    A glucose-6-phosphate dehydrogenase (G6PD) deficient strain of mouse (GPDX) which was developed using the ethylating agent ethylnitrosourea (ENU) has been used to study clonality in epithelial tissues...
  36. Jain M, Cui L, Brenner D, Wang B, Handy D, Leopold J, et al. Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase. Circulation. 2004;109:898-903 pubmed
    ..Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway, generates NADPH in a reaction linked to the de novo ..
  37. Peters J, Ball S. Parental influences on expression of glucose-6-phosphate dehydrogenase, G6pd, in the mouse; a case of imprinting. Genet Res. 1990;56:245-52 pubmed
    Glucose-6-phosphate dehydrogenase (G6PD) activity was measured in blood from heterozygotes for the normal allele G6pda and the low activity allele G6pda-mlNeu...
  38. Rajasekaran N, Connell P, Christians E, Yan L, Taylor R, Orosz A, et al. Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. Cell. 2007;130:427-39 pubmed
    ..GSH), which is due to the augmented expression and enzymatic activities of glucose-6-phosphate dehydrogenase (G6PD), glutathione reductase, and glutathione peroxidase...
  39. Wilmanski J, Siddiqi M, Deitch E, Spolarics Z. Augmented IL-10 production and redox-dependent signaling pathways in glucose-6-phosphate dehydrogenase-deficient mouse peritoneal macrophages. J Leukoc Biol. 2005;78:85-94 pubmed
    Glucose-6-phosphate dehydrogenase (G6PD) supports cellular antioxidant pathways. G6PD deficiency is associated with malaria protection but was shown to worsen the clinical course to injury...
  40. Nichols K, Kirby G. Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress. Biochem Pharmacol. 2008;75:1230-9 pubmed
    ..in the regulation of CYP2A5 expression using an oxidative stress-sensitive glucose-6-phosphate dehydrogenase (G6PD)-deficient mouse model...
  41. Hoki Y, Kimura N, Kanbayashi M, Amakawa Y, Ohhata T, Sasaki H, et al. A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse. Development. 2009;136:139-46 pubmed publisher
  42. Baader S, Schilling M, Rosengarten B, Pretsch W, Teutsch H, Oberdick J, et al. Purkinje cell lineage and the topographic organization of the cerebellar cortex: a view from X inactivation mosaics. Dev Biol. 1996;174:393-406 pubmed
    ..experiment and carrying an activity-attenuated allele of the X-linked enzyme glucose-6-phosphate dehydrogenase (G6PD), to analyze the development of the cell lineage leading to cerebellar Purkinje neurons...
  43. Neifer S, Jung A, Bienzle U. Characterization of erythrocytic glucose-6-phosphate dehydrogenase in a mouse strain with reduced G6PD activity. Biomed Biochim Acta. 1991;50:233-8 pubmed
    Erythrocytic glucose-6-phosphate dehydrogenase (G6PD) of a mutant mouse strain with X-linked G6PD-deficiency was purified and compared with the wildtype G6PD by biochemical and physiological characteristics...
  44. Mullins L, Stephenson D, Grant S, Chapman V. Efficient linkage of 10 loci in the proximal region of the mouse X chromosome. Genomics. 1990;7:19-30 pubmed
    ..The possible significance of the Xlr loci is discussed with respect to other X-chromosome loci that regulate the immune response. ..
  45. Toniolo D, Filippi M, Dono R, Lettieri T, Martini G. The CpG island in the 5' region of the G6PD gene of man and mouse. Gene. 1991;102:197-203 pubmed
    ..sequence of the entire CpG island in the 5' region of the human glucose-6-phosphate dehydrogenase-encoding gene (G6PD) and of the corresponding region in mouse was determined...
  46. Brockdorff N, Cross G, Cavanna J, Fisher E, Lyon M, Davies K, et al. The mapping of a cDNA from the human X-linked Duchenne muscular dystrophy gene to the mouse X chromosome. Nature. 1987;328:166-8 pubmed
    ..But the close genetic linkage of mdx to G6PD and Hprt on the mouse X chromosome, coupled with its comparatively mild pathology, have suggested that the mdx ..
  47. Chatterjee A, Faust C, Molinari Storey L, Kiochis P, Poustka A, Herman G. A 2.3-Mb yeast artificial chromosome contig spanning from Gabra3 to G6pd on the mouse X chromosome. Genomics. 1994;21:49-57 pubmed
    ..3 Mb has been constructed for the region of the mouse X chromosome between Gabra3 and G6pd. YACs were isolated from four genomic libraries by PCR or hybridization screening for the loci Gabra3, DXHX1104, ..
  48. Park J, Rho H, Kim K, Choe S, Lee Y, Kim J. Overexpression of glucose-6-phosphate dehydrogenase is associated with lipid dysregulation and insulin resistance in obesity. Mol Cell Biol. 2005;25:5146-57 pubmed
    Glucose-6-phosphate dehydrogenase (G6PD) produces cellular NADPH, which is required for the biosynthesis of fatty acids and cholesterol...
  49. Kalantry S, Purushothaman S, Bowen R, Starmer J, Magnuson T. Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation. Nature. 2009;460:647-51 pubmed publisher
    ..Xp-linked gene silencing associated with mouse imprinted XCI, therefore, can initiate in the embryo independently of Xist RNA. ..
  50. Du G, Xiao M, Wei X, Zhou C, Li S, Cai W. Hepatic transcriptional profiling response to fava bean-induced oxidative stress in glucose-6-phosphate dehydrogenase-deficient mice. Gene. 2018;652:66-77 pubmed publisher
    ..analyze liver genes expression alterations underlying the effects of FB in C3H (Wild Type, WT) and G6PD-deficient (G6PDx) mice and to evaluate and visualize the collective annotation of a list of genes to Gene Ontology (GO) terms ..
  51. White K, Kim M, Ding D, Han C, Park H, Meneses Z, et al. G6pd Deficiency Does Not Affect the Cytosolic Glutathione or Thioredoxin Antioxidant Defense in Mouse Cochlea. J Neurosci. 2017;37:5770-5781 pubmed publisher
    Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be ..
  52. Beutler E. Study of glucose-6-phosphate dehydrogenase: history and molecular biology. Am J Hematol. 1993;42:53-8 pubmed
    Glucose-6-phosphate dehydrogenase (G6PD) deficiency was discovered in the 1950s. The history of the development of knowledge about G6PD deficiency is reviewed here...
  53. Disteche C, McConnell G, Grant S, Stephenson D, Chapman V, Gandy S, et al. Comparison of the physical and recombination maps of the mouse X chromosome. Genomics. 1989;5:177-84 pubmed
    ..These results are discussed in comparison to the human X-chromosome map. ..
  54. Brockdorff N, Amar L, Brown S. Pulse-field linkage of the P3, G6pd and Cf-8 genes on the mouse X chromosome: demonstration of synteny at the physical level. Nucleic Acids Res. 1989;17:1315-26 pubmed
    ..The three genes, P3, G6pd and Cf-8 all lie within 400 Kb of DNA...
  55. O Brien S, Nash W. Genetic mapping in mammals: chromosome map of domestic cat. Science. 1982;216:257-65 pubmed
    ..Many of these same linkage groups have not been conserved in the murine genome. The genetic and evolutionary implications of comparative mapping analysis among mammalian species are discussed. ..
  56. Hodge D, Charron T, Stabile L, Klautky S, Salati L. Structural characterization and tissue-specific expression of the mouse glucose-6-phosphate dehydrogenase gene. DNA Cell Biol. 1998;17:283-91 pubmed
    Glucose-6-phosphate dehydrogenase (G6PD) activity differs among tissues and, in liver, with the dietary state of the mouse...
  57. Favor J, Pretsch W. Genetic localization and phenotypic expression of X-linked cataract (Xcat) in Mus musculus. Genet Res. 1990;56:157-62 pubmed
    ..The Xcat mutation may be a useful marker for a distal region of the mouse X-chromosome which is relatively sparsely marked and the X-linked cataract mutation may be employed in gene expression and lens development studies. ..
  58. Stephenson D, Grant S, Mullins L, Scolese A, O Reilly A, Chapman V. X-chromosome gene order in different Mus species crosses. Curr Top Microbiol Immunol. 1988;137:18-24 pubmed
  59. Zollo M, D Urso M, Schlessinger D, Chen E. Sequence of mouse glucose-6-phosphate dehydrogenase cDNA. DNA Seq. 1993;3:319-22 pubmed
    A full-length mouse glucose-6-phosphate dehydrogenase (G6PD) cDNA has been isolated and sequenced, and the evolutionary conservation of many portions of the sequence has been verified by comparison with that of human and other sources.
  60. Spencer N, Yan Z, Boudreau R, Zhang Y, Luo M, Li Q, et al. Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4. J Biol Chem. 2011;286:8977-87 pubmed publisher
    ..and G6P also induced nuclear O(2)(·-) production, suggesting that intranuclear glucose-6-phosphate dehydrogenase (G6PD) can control NOX4 activity through nuclear NADPH production...
  61. Hoki Y, Ikeda R, Mise N, Sakata Y, Ohhata T, Sasaki H, et al. Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse. Development. 2011;138:2649-59 pubmed publisher
    ..Xist(IVS), which can be referred to as a partial loss-of-function mutation, would provide an opportunity to dissect the molecular mechanism of Xist RNA-mediated chromosome silencing. ..
  62. Erickson R, Harper K. A major autosomal gene effect on activity of glucose 6-phosphate dehydrogenase segregating between recombinant inbred lines of mice. Genet Res. 1980;36:91-7 pubmed
  63. Kanno H, Huang I, Kan Y, Yoshida A. Two structural genes on different chromosomes are required for encoding the major subunit of human red cell glucose-6-phosphate dehydrogenase. Cell. 1989;58:595-606 pubmed
    ..The minor subunit can be fully encoded by the X-linked G6PD cDNA, but the NH2-terminal region of the major subunit cannot...
  64. Danciger M, Farber D, Kozak C. Genetic mapping of three GABAA receptor-subunit genes in the mouse. Genomics. 1993;16:361-5 pubmed
    ..The Gabrb-1, Gabra-2 pair of genes on Chr 5 maps near the mouse "circling mutation" pi (pirouette). ..
  65. Grant S, Mattei M, Galland F, Stephenson D, Keitz B, Birnbaum D, et al. Localization of the mouse Mcf-2 (Dbl) protooncogene within a conserved linkage group on the mouse X chromosome. Cytogenet Cell Genet. 1990;54:175-81 pubmed
    ..factor IX, within a large conserved linkage group between the mouse and human genomes which extends from HPRT to G6PD on the X chromosomes of both mammalian species...
  66. Fico A, Paglialunga F, Cigliano L, Abrescia P, Verde P, Martini G, et al. Glucose-6-phosphate dehydrogenase plays a crucial role in protection from redox-stress-induced apoptosis. Cell Death Differ. 2004;11:823-31 pubmed
    Glucose-6-phosphate dehydrogenase-deleted embryonic stem (ES) cells (G6pd Delta) proliferate in vitro without special requirements, but when challenged with oxidants fail to sustain glutathione disulphide reconversion to reduced ..
  67. Felix K, Rockwood L, Pretsch W, Bornkamm G, Janz S. Redox imbalance and mutagenesis in spleens of mice harboring a hypomorphic allele of Gpdx(a) encoding glucose 6-phosphate dehydrogenase. Free Radic Biol Med. 2003;34:226-32 pubmed
    ..gene to study mutagenesis (pUR288) were used to demonstrate that moderate glucose 6-phosphate dehydrogenase (G6PD) deficiency causes elevated mutagenesis and endogenous oxidative stress in the spleen...
  68. Epstein C. Expression of the mammalian X chromosome before and after fertilization. Science. 1972;175:1467-8 pubmed
    ..These results indicate that the X-linked enzyme lacuts is expressed sometimne after fertilization but before the morula stage. ..
  69. Spolarics Z, Condon M, Siddiqi M, Machiedo G, Deitch E. Red blood cell dysfunction in septic glucose-6-phosphate dehydrogenase-deficient mice. Am J Physiol Heart Circ Physiol. 2004;286:H2118-26 pubmed
  70. Chen T, Tan S, Yeo R, Teh B, Luo R, Li G, et al. Delineating biological pathways unique to embryonic stem cell-derived insulin-producing cell lines from their noninsulin-producing progenitor cell lines. Endocrinology. 2010;151:3600-10 pubmed publisher
  71. Ko C, Li K, Li C, Ng P, Fung K, James A, et al. Development of a novel mouse model of severe glucose-6-phosphate dehydrogenase (G6PD)-deficiency for in vitro and in vivo assessment of hemolytic toxicity to red blood cells. Blood Cells Mol Dis. 2011;47:176-81 pubmed publisher
    Studies of hemolytic agents on G6PD-deficient subjects have been extensively performed on red blood cells obtained from donors, only using in vitro methods...
  72. Dong L, Li L, Song Y, Duan Z, Sun S, Lin Y, et al. TRAF6-Mediated SM22α K21 Ubiquitination Promotes G6PD Activation and NADPH Production, Contributing to GSH Homeostasis and VSMC Survival In Vitro and In Vivo. Circ Res. 2015;117:684-94 pubmed publisher
    ..We showed that the expression and activity of glucose-6-phosphate dehydrogenase (G6PD) are promoted in platelet-derived growth factor (PDGF)-BB-induced proliferative VSMCs...