G protein coupled receptor 30

Summary

Gene Symbol: G protein coupled receptor 30
Description: G protein-coupled estrogen receptor 1
Alias: 6330420K13Rik, CMKRL2, Ceprl, FEG-1, GPCR-Br, Gper, Gpr30, G-protein coupled estrogen receptor 1, G-protein coupled receptor 30, chemoattractant receptor-like 2, constitutively expressed peptide-like receptor like, mER, membrane estrogen receptor
Species: mouse

Top Publications

  1. Feng Y, Gregor P. Cloning of a novel member of the G protein-coupled receptor family related to peptide receptors. Biochem Biophys Res Commun. 1997;231:651-4 pubmed
    ..The ubiquitous tissue distribution of CEPR, its expression in early development, and its conservation in evolution indicate a potentially important biological function for this receptor and its putative peptide ligand. ..
  2. Ford J, Hajibeigi A, Long M, Hahner L, Gore C, Hsieh J, et al. GPR30 deficiency causes increased bone mass, mineralization, and growth plate proliferative activity in male mice. J Bone Miner Res. 2011;26:298-307 pubmed publisher
    ..Recently, in vitro studies have shown that the G protein-coupled receptor GPR30 is a functional estrogen receptor (ER)...
  3. Kastenberger I, Lutsch C, Schwarzer C. Activation of the G-protein-coupled receptor GPR30 induces anxiogenic effects in mice, similar to oestradiol. Psychopharmacology (Berl). 2012;221:527-35 pubmed publisher
    ..oestrogen-induced anxiogenic-like effects might be mediated, at least in part, by the G protein-coupled receptor GPR30. The short-term application of specific agonists against the alpha and beta oestrogen receptors did not result in ..
  4. Akama K, Thompson L, Milner T, McEwen B. Post-synaptic density-95 (PSD-95) binding capacity of G-protein-coupled receptor 30 (GPR30), an estrogen receptor that can be identified in hippocampal dendritic spines. J Biol Chem. 2013;288:6438-50 pubmed publisher
    ..E2) modulates dendritic spine plasticity in the cornu ammonis 1 (CA1) region of the hippocampus, and GPR30 (G-protein coupled estrogen receptor 1 (GPER1)) is an estrogen-sensitive G-protein-coupled receptor (GPCR) that is ..
  5. Sirianni R, Chimento A, Ruggiero C, De Luca A, Lappano R, Ando S, et al. The novel estrogen receptor, G protein-coupled receptor 30, mediates the proliferative effects induced by 17beta-estradiol on mouse spermatogonial GC-1 cell line. Endocrinology. 2008;149:5043-51 pubmed publisher
    ..Using the GC-1 cell line as a model system, we demonstrated that GC-1 cells express GPR30 and ERalpha but not ERbeta...
  6. Windahl S, Andersson N, Chagin A, Mårtensson U, Carlsten H, Olde B, et al. The role of the G protein-coupled receptor GPR30 in the effects of estrogen in ovariectomized mice. Am J Physiol Endocrinol Metab. 2009;296:E490-6 pubmed publisher
    In vitro studies suggest that the membrane G protein-coupled receptor GPR30 is a functional estrogen receptor (ER)...
  7. Wang C, Dehghani B, Magrisso I, Rick E, Bonhomme E, Cody D, et al. GPR30 contributes to estrogen-induced thymic atrophy. Mol Endocrinol. 2008;22:636-48 pubmed
    ..In this study, the roles played by the membrane estrogen receptor, G protein-coupled receptor 30 (GPR30), and the intracellular estrogen receptors, estrogen receptor ..
  8. Mårtensson U, Salehi S, Windahl S, Gomez M, Swärd K, Daszkiewicz Nilsson J, et al. Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice. Endocrinology. 2009;150:687-98 pubmed publisher
    ..However, the physiological role of GPR30 in vivo is unknown, and it remains to be determined whether GPR30 is an estrogen receptor also in vivo...
  9. Brunsing R, Prossnitz E. Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1. Immunology. 2011;134:93-106 pubmed publisher
    ..have shown that the small molecule G-1, an agonist of the membrane-bound G-protein-coupled estrogen receptor GPER, attenuates disease in an animal model of autoimmune encephalomyelitis...

More Information

Publications78

  1. Hazell G, Yao S, Roper J, Prossnitz E, O Carroll A, Lolait S. Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues. J Endocrinol. 2009;202:223-36 pubmed publisher
    Recently, the G protein-coupled receptor GPR30 has been identified as a novel oestrogen receptor (ER). The distribution of the receptor has been thus far mapped only in the rat central nervous system...
  2. Filardo E, Quinn J, Pang Y, Graeber C, Shaw S, Dong J, et al. Activation of the novel estrogen receptor G protein-coupled receptor 30 (GPR30) at the plasma membrane. Endocrinology. 2007;148:3236-45 pubmed
    G protein-coupled receptor 30 (GPR30), a seven-transmembrane receptor (7TMR), is associated with rapid estrogen-dependent, G protein signaling and specific estrogen binding. At present, the subcellular site of GPR30 action is unclear...
  3. Rettew J, McCall S, Marriott I. GPR30/GPER-1 mediates rapid decreases in TLR4 expression on murine macrophages. Mol Cell Endocrinol. 2010;328:87-92 pubmed publisher
    ..The recent demonstration that GPR30 can mediate rapid non-genomic events and may function as a novel transmembrane estrogen receptor could provide a ..
  4. Hutchens M, Fujiyoshi T, Komers R, Herson P, Anderson S. Estrogen protects renal endothelial barrier function from ischemia-reperfusion in vitro and in vivo. Am J Physiol Renal Physiol. 2012;303:F377-85 pubmed publisher
    ..6 ± 10.8%, P < 0.05). This effect was reversed by coadministration of G protein-coupled receptor 30 (GPR30) antagonist G15 with 17?-estradiol (OGD-estrogen-G15: 89.5 ± 6.9, P < 0.05 compared with 17?-estradiol)...
  5. Teplyuk N, Galindo M, Teplyuk V, Pratap J, Young D, Lapointe D, et al. Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors. J Biol Chem. 2008;283:27585-97 pubmed publisher
    ..g. Rgs2, Rgs4, Rgs5, Rgs16, Gpr23, Gpr30, Gpr54, Gpr64, and Gna13)...
  6. Otto C, Fuchs I, Kauselmann G, Kern H, Zevnik B, Andreasen P, et al. GPR30 does not mediate estrogenic responses in reproductive organs in mice. Biol Reprod. 2009;80:34-41 pubmed publisher
    The G protein-coupled receptor Gpr30 (Gper) was recently claimed to bind to estradiol and to activate cytoplasmic signal transduction pathways in response to estradiol...
  7. Wang C, Dehghani B, Li Y, Kaler L, Proctor T, Vandenbark A, et al. Membrane estrogen receptor regulates experimental autoimmune encephalomyelitis through up-regulation of programmed death 1. J Immunol. 2009;182:3294-303 pubmed publisher
    ..In this study, we found that signaling through the putative membrane estrogen receptor, G protein-coupled receptor 30 (GPR30), was sufficient to mediate protection against EAE, which was ..
  8. Zhang B, Subramanian S, Dziennis S, Jia J, Uchida M, Akiyoshi K, et al. Estradiol and G1 reduce infarct size and improve immunosuppression after experimental stroke. J Immunol. 2010;184:4087-94 pubmed publisher
    ..c. implant or the putative membrane estrogen receptor agonist, G1...
  9. Hofmeister M, Damkier H, Christensen B, Olde B, Fredrik Leeb Lundberg L, Fenton R, et al. 17?-Estradiol induces nongenomic effects in renal intercalated cells through G protein-coupled estrogen receptor 1. Am J Physiol Renal Physiol. 2012;302:F358-68 pubmed publisher
    ..G protein-coupled estrogen receptor 1 (GPER1 or GPR30) was detected in microdissected DCT2/CNT/iCCD by RT-PCR...
  10. Isensee J, Meoli L, Zazzu V, Nabzdyk C, Witt H, Soewarto D, et al. Expression pattern of G protein-coupled receptor 30 in LacZ reporter mice. Endocrinology. 2009;150:1722-30 pubmed publisher
    ..the function of G protein-coupled receptor (GPR)-30 with nongenomic effects of estrogen, suggesting that GPR30 might be a G-protein coupled estrogen receptor...
  11. Haas E, Bhattacharya I, Brailoiu E, Damjanovic M, Brailoiu G, Gao X, et al. Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity. Circ Res. 2009;104:288-91 pubmed publisher
    ..stimulation of the intracellular, transmembrane G protein-coupled estrogen receptor (GPER), also known as GPR30, acutely lowers blood pressure after infusion in normotensive rats and dilates both rodent and human arterial ..
  12. Wei T, Chen W, Wen L, Zhang J, Zhang Q, Yang J, et al. G protein-coupled estrogen receptor deficiency accelerates liver tumorigenesis by enhancing inflammation and fibrosis. Cancer Lett. 2016;382:195-202 pubmed publisher
    G protein-coupled estrogen receptor (GPER) is a novel estrogen-binding receptor involved in many pathological conditions, including cancer. In this study, we investigated the effect of GPER on hepatocellular carcinoma (HCC)...
  13. Ge L, Chen Z, Liu H, Zhang K, Liu H, Huang H, et al. Involvement of activating ERK1/2 through G protein coupled receptor 30 and estrogen receptor ?/? in low doses of bisphenol A promoting growth of Sertoli TM4 cells. Toxicol Lett. 2014;226:81-9 pubmed publisher
    ..Exposure of TM4 cells to G15 or ICI 182,780, which are specific antagonists of GPR30 and estrogen receptor ?/? (ER?/?), respectively, abolished BPA-induced proliferation of cells, which suggests that ..
  14. Cheng S, Dong J, Pang Y, LaRocca J, Hixon M, Thomas P, et al. Anatomical location and redistribution of G protein-coupled estrogen receptor-1 during the estrus cycle in mouse kidney and specific binding to estrogens but not aldosterone. Mol Cell Endocrinol. 2014;382:950-9 pubmed publisher
    Prior studies have linked renoprotective effects of estrogens to G-protein-coupled estrogen receptor-1 (GPER-1) and suggest that aldosterone may also activate GPER-1...
  15. Meyer M, Amann K, Field A, Hu C, Hathaway H, Kanagy N, et al. Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstriction. Hypertension. 2012;59:507-12 pubmed publisher
    ..This study investigated whether the intracellular transmembrane G protein-coupled estrogen receptor (GPER) regulates vascular reactivity in mice...
  16. Nadal A, Alonso Magdalena P, Soriano S, Ripoll C, Fuentes E, Quesada I, et al. Role of estrogen receptors alpha, beta and GPER1/GPR30 in pancreatic beta-cells. Front Biosci (Landmark Ed). 2011;16:251-60 pubmed
    ..In addition, the G protein-coupled estrogen receptor (GPER1/GPR30) seems to be implicated in the E2-regulation of stimulus-secretion coupling in the three cell types of the islet...
  17. Meyer M, Fredette N, Daniel C, Sharma G, Amann K, Arterburn J, et al. Obligatory role for GPER in cardiovascular aging and disease. Sci Signal. 2016;9:ra105 pubmed publisher
    Pharmacological activation of the heptahelical G protein-coupled estrogen receptor (GPER) by selective ligands counteracts multiple aspects of cardiovascular disease...
  18. Kastenberger I, Schwarzer C. GPER1 (GPR30) knockout mice display reduced anxiety and altered stress response in a sex and paradigm dependent manner. Horm Behav. 2014;66:628-36 pubmed publisher
    The putative estrogen receptor GPER1 (the former orphan receptor GPR30) is discussed to be involved in emotional and cognitive functions and stress control...
  19. Recchia A, De Francesco E, Vivacqua A, Sisci D, Panno M, Ando S, et al. The G protein-coupled receptor 30 is up-regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) in breast cancer cells and cardiomyocytes. J Biol Chem. 2011;286:10773-82 pubmed publisher
    b>GPR30, also known as GPER, has been suggested to mediate rapid effects induced by estrogens in diverse normal and cancer tissues. Hypoxia is a common feature of solid tumors involved in apoptosis, cell survival, and proliferation...
  20. Liu S, Han J, Zhang N, Tian Z, Li X, Zhao M. Neuroprotective effects of oestrogen against oxidative toxicity through activation of G-protein-coupled receptor 30 receptor. Clin Exp Pharmacol Physiol. 2011;38:577-85 pubmed publisher
    ..The aim of the present study was to investigate the role of G-protein-coupled receptor 30 (GPR30), a new kind of oestrogen receptor, in the neuroprotection against oxidative insult. 2...
  21. Liu S, Le May C, Wong W, Ward R, Clegg D, Marcelli M, et al. Importance of extranuclear estrogen receptor-alpha and membrane G protein-coupled estrogen receptor in pancreatic islet survival. Diabetes. 2009;58:2292-302 pubmed publisher
    ..of islet survival is ERE independent and that E(2) favors islet survival through extranuclear and membrane estrogen receptor signaling. We show that ERbeta plays a minor cytoprotective role compared to ERalpha...
  22. Ruiz Palmero I, Hernando M, Garcia Segura L, Arevalo M. G protein-coupled estrogen receptor is required for the neuritogenic mechanism of 17?-estradiol in developing hippocampal neurons. Mol Cell Endocrinol. 2013;372:105-15 pubmed publisher
    ..In this study we have explored whether G-protein coupled estrogen receptor 1 (GPER) participates in this hormonal action...
  23. Waters E, Thompson L, Patel P, Gonzales A, Ye H, Filardo E, et al. G-protein-coupled estrogen receptor 1 is anatomically positioned to modulate synaptic plasticity in the mouse hippocampus. J Neurosci. 2015;35:2384-97 pubmed publisher
    ..Here, we examined whether the membrane estrogen receptor, G-protein-coupled estrogen receptor 1 (GPER1), is anatomically positioned in the dorsal hippocampus of ..
  24. Yu L, Qu T, Zhang S, Yuan D, Xu Q, Zhang J, et al. GPR30 Mediates the Fast Effect of Estrogen on Mouse Blastocyst and its Role in Implantation. Reprod Sci. 2015;22:1312-20 pubmed publisher
    ..The purpose of the present study is to investigate the physiological relevance of G protein-coupled receptor 30 (GPR30) in the fast effect of estrogen on mouse blastocyst and in embryo implantation...
  25. Sandén C, Broselid S, Cornmark L, Andersson K, Daszkiewicz Nilsson J, Mårtensson U, et al. G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments. Mol Pharmacol. 2011;79:400-10 pubmed publisher
    G protein-coupled receptor 30 [G protein-coupled estrogen receptor 1 (GPER1)], has been introduced as a membrane estrogen receptor and a candidate cancer biomarker and therapeutic target...
  26. Meyer M, Fredette N, Barton M, Prossnitz E. G protein-coupled estrogen receptor inhibits vascular prostanoid production and activity. J Endocrinol. 2015;227:61-9 pubmed publisher
    ..Here, we studied whether the G protein-coupled estrogen receptor (GPER) mediates estrogen-dependent inhibitory effects on prostanoid production and activity under pro-inflammatory ..
  27. Bopassa J, Eghbali M, Toro L, Stefani E. A novel estrogen receptor GPER inhibits mitochondria permeability transition pore opening and protects the heart against ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2010;298:H16-23 pubmed publisher
    Several studies have recently demonstrated that G protein-coupled receptor 30 (GPER) can directly bind to estrogen and mediate its action...
  28. Zhu P, Yuen J, Sham K, Cheng C. GPER mediates the inhibitory actions of estrogen on adipogenesis in 3T3-L1 cells through perturbation of mitotic clonal expansion. Gen Comp Endocrinol. 2013;193:19-26 pubmed publisher
    G-protein-coupled estrogen receptor 1 (GPER) mediates non-genomic signaling of estrogenic events...
  29. Feldman R, Ding Q, Hussain Y, Limbird L, Pickering J, Gros R. Aldosterone mediates metastatic spread of renal cancer via the G protein-coupled estrogen receptor (GPER). FASEB J. 2016;30:2086-96 pubmed publisher
    ..tested the hypothesis that aldosterone regulates cancer cell growth/spread via G protein-coupled estrogen receptor (GPER) activation...
  30. Balhuizen A, Kumar R, Amisten S, Lundquist I, Salehi A. Activation of G protein-coupled receptor 30 modulates hormone secretion and counteracts cytokine-induced apoptosis in pancreatic islets of female mice. Mol Cell Endocrinol. 2010;320:16-24 pubmed publisher
    The role of the newly discovered estrogen receptor GPR30 in islet physiology and pathophysiology is unclear...
  31. Wang H, Sun X, Chou J, Lin M, Ferrario C, Zapata Sudo G, et al. Inflammatory and mitochondrial gene expression data in GPER-deficient cardiomyocytes from male and female mice. Data Brief. 2017;10:465-473 pubmed publisher
    We previously showed that cardiomyocyte-specific G protein-coupled estrogen receptor (GPER) gene deletion leads to sex-specific adverse effects on cardiac structure and function; alterations which may be due to distinct differences in ..
  32. Sharma G, Hu C, Brigman J, Zhu G, Hathaway H, Prossnitz E. GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state. Endocrinology. 2013;154:4136-45 pubmed publisher
    ..The role of the G protein-coupled estrogen receptor (GPER/GPR30), particularly in males, in these pathologies remains unclear...
  33. Ylikomi T, Vienonen A, Ahola T. G protein-coupled receptor 30 down-regulates cofactor expression and interferes with the transcriptional activity of glucocorticoid. Eur J Biochem. 2004;271:4159-68 pubmed
    G protein-coupled receptor 30 (GPR30) has previously been described to be important in steroid-mediated growth and to inhibit cell proliferation...
  34. Gingerich S, Kim G, Chalmers J, Koletar M, Wang X, Wang Y, et al. Estrogen receptor ? and G-protein coupled receptor 30 mediate the neuroprotective effects of 17?-estradiol in novel murine hippocampal cell models. Neuroscience. 2010;170:54-66 pubmed publisher
    ..genes and receptors suggested to play a role in neuroprotection, including estrogen receptors ERalpha, ERbeta, and GPR30. We find that pretreatment with E2 (10 or 100 nM) for 24 h significantly reduced cell death induced by glutamate ..
  35. Okamoto M, Suzuki T, Mizukami Y, Ikeda T. The membrane-type estrogen receptor G-protein-coupled estrogen receptor suppresses lipopolysaccharide-induced interleukin 6 via inhibition of nuclear factor-kappa B pathway in murine macrophage cells. Anim Sci J. 2017;88:1870-1879 pubmed publisher
    The female sex hormone estrogen exerts anti-inflammatory effects. The G-protein-coupled estrogen receptor (GPER) has been recently identified as a novel membrane-type estrogen receptor that can mediate non-genomic estrogenic effects on ..
  36. Mendes Oliveira J, Lopes Campos F, Videira R, Baltazar G. GPER activation is effective in protecting against inflammation-induced nigral dopaminergic loss and motor function impairment. Brain Behav Immun. 2017;64:296-307 pubmed publisher
    ..results from our group and others demonstrated that selective activation of G protein-coupled estrogen receptor (GPER) with the agonist G1 can protect DA neurons from 1-methyl-4-phenylpyridinium (MPP+) and 1-methyl-4-..
  37. Bourque M, Morissette M, Cote M, Soulet D, Di Paolo T. Implication of GPER1 in neuroprotection in a mouse model of Parkinson's disease. Neurobiol Aging. 2013;34:887-901 pubmed publisher
    ..This study showed an important role of GPER1 in neuroprotection and that G1 is as potent as 17?-estradiol in mediating beneficial effects. ..
  38. Wang H, Sun X, Chou J, Lin M, Ferrario C, Zapata Sudo G, et al. Cardiomyocyte-specific deletion of the G protein-coupled estrogen receptor (GPER) leads to left ventricular dysfunction and adverse remodeling: A sex-specific gene profiling analysis. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1870-1882 pubmed publisher
    Activation of G protein-coupled estrogen receptor (GPER) by its agonist, G1, protects the heart from stressors such as pressure-overload, ischemia, a high-salt diet, estrogen loss, and aging, in various male and female animal models...
  39. Liu Y, Li Y, Zhang D, Liu J, Gou K, Cui S. Mitogen-Activated Protein Kinase 8 (MAP3K8) Mediates the Signaling Pathway of Estradiol Stimulating Progesterone Production Through G Protein-Coupled Receptor 30 (GPR30) in Mouse Corpus Luteum. Mol Endocrinol. 2015;29:703-15 pubmed publisher
    ..These novel findings are critical for our understanding the ovary physiology and pathological mechanism. ..
  40. Zhang X, Ke S, Chen K, Li J, Ma L, Jiang X. Diethylstilbestrol affects the expression of GPER in the gubernaculum testis. Int J Clin Exp Pathol. 2015;8:7217-22 pubmed
    ..and its nongenomic effects on gubernaculum testis cells may be mediated by G protein-coupled estrogen receptor (GPER)...
  41. Otto C, Rohde Schulz B, Schwarz G, Fuchs I, Klewer M, Brittain D, et al. G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol. Endocrinology. 2008;149:4846-56 pubmed publisher
    ..Recently, an orphan G protein-coupled receptor, GPR30, has been claimed to bind to and to signal in response to estradiol...
  42. Kubota T, Matsumoto H, Kirino Y. Ameliorative effect of membrane-associated estrogen receptor G protein coupled receptor 30 activation on object recognition memory in mouse models of Alzheimer's disease. J Pharmacol Sci. 2016;131:219-22 pubmed publisher
    Membrane-associated estrogen receptor "G protein-coupled receptor 30" (GPR30) has been implicated in spatial recognition memory and protection against neuronal death...
  43. Zhao T, Shi F, Hu J, He S, Ding Q, Ma L. GPER1 mediates estrogen-induced neuroprotection against oxygen-glucose deprivation in the primary hippocampal neurons. Neuroscience. 2016;328:117-26 pubmed publisher
    ..Overall, these research results could enhance our understanding of the neuroprotective actions for estrogen, and provide a new therapeutic target for improving stroke outcome and ameliorating degenerative neurological diseases. ..
  44. Yates M, Li Y, Chlebeck P, Offner H. GPR30, but not estrogen receptor-alpha, is crucial in the treatment of experimental autoimmune encephalomyelitis by oral ethinyl estradiol. BMC Immunol. 2010;11:20 pubmed publisher
    ..the current study, the influence of estrogen receptor-alpha (ERalpha) and the G-protein coupled estrogen receptor (GPR30 or GPER) on EE's ability to treat EAE was explored...
  45. De Marco P, Romeo E, Vivacqua A, Malaguarnera R, Abonante S, Romeo F, et al. GPER1 is regulated by insulin in cancer cells and cancer-associated fibroblasts. Endocr Relat Cancer. 2014;21:739-53 pubmed publisher
    ..Altogether, our data indicate that GPER1 may be included among the complex network of transduction signaling triggered by insulin that drives cells toward cancer progression. ..
  46. CLEGG D, Hevener A, Moreau K, Morselli E, Criollo A, Van Pelt R, et al. Sex Hormones and Cardiometabolic Health: Role of Estrogen and Estrogen Receptors. Endocrinology. 2017;158:1095-1105 pubmed publisher
  47. Marjon N, Hu C, Hathaway H, Prossnitz E. G protein-coupled estrogen receptor regulates mammary tumorigenesis and metastasis. Mol Cancer Res. 2014;12:1644-1654 pubmed publisher
    ..The discovery of the G protein-coupled estrogen receptor (GPER) suggested an additional mechanism through which E2 could exert its effects in breast cancer...
  48. Lenhart P, Broselid S, Barrick C, Leeb Lundberg L, Caron K. G-protein-coupled receptor 30 interacts with receptor activity-modifying protein 3 and confers sex-dependent cardioprotection. J Mol Endocrinol. 2013;51:191-202 pubmed publisher
    ..We sought to determine whether RAMP3 interacts with GPR30, also known as G-protein-coupled estrogen receptor 1...
  49. Anchan D, Gafur A, Sano K, Ogawa S, Vasudevan N. Activation of the GPR30 receptor promotes lordosis in female mice. Neuroendocrinology. 2014;100:71-80 pubmed publisher
    ..b>GPR30 (G-protein coupled receptor 30), also known as GPER1, a putative membrane ER (mER), is a G protein-coupled ..
  50. Ronda A, Boland R. Intracellular Distribution and Involvement of GPR30 in the Actions of E2 on C2C12 Cells. J Cell Biochem. 2016;117:793-805 pubmed publisher
    G-protein-coupled receptor 30 (GPR30) is an estrogen receptor that initiates several rapid, non-genomic signaling events triggered by E2...
  51. Meyer M, Fredette N, Howard T, Hu C, Ramesh C, Daniel C, et al. G protein-coupled estrogen receptor protects from atherosclerosis. Sci Rep. 2014;4:7564 pubmed publisher
    ..we used genetic and pharmacologic approaches to investigate the role of the G protein-coupled estrogen receptor (GPER) in atherosclerosis...
  52. Kajta M, Wnuk A, Rzemieniec J, Litwa E, Lason W, Zelek Molik A, et al. Depressive-like effect of prenatal exposure to DDT involves global DNA hypomethylation and impairment of GPER1/ESR1 protein levels but not ESR2 and AHR/ARNT signaling. J Steroid Biochem Mol Biol. 2017;171:94-109 pubmed publisher
    ..Because p,p'-DDT caused sex- and age-independent attenuation of GPER1, we suggest that impairment of GPER1 signaling plays a key role in the propagation of DDT-induced depressive-like symptoms. ..
  53. Hutchens M, Kosaka Y, Zhang W, Fujiyoshi T, Murphy S, Alkayed N, et al. Estrogen-mediated renoprotection following cardiac arrest and cardiopulmonary resuscitation is robust to GPR30 gene deletion. PLoS ONE. 2014;9:e99910 pubmed publisher
    ..We hypothesized that the G protein estrogen receptor (GPR30) mediates the renoprotective effect of estrogen...
  54. Evans N, Bayliss A, Reale V, Evans P. Characterisation of Signalling by the Endogenous GPER1 (GPR30) Receptor in an Embryonic Mouse Hippocampal Cell Line (mHippoE-18). PLoS ONE. 2016;11:e0152138 pubmed publisher
    ..been suggested to be mediated via the activation of the estrogen sensitive G-protein coupled receptor (GPER1 or GPR30)...
  55. Lai S, Collins B, Colson B, Kararigas G, Lowe D. Estradiol modulates myosin regulatory light chain phosphorylation and contractility in skeletal muscle of female mice. Am J Physiol Endocrinol Metab. 2016;310:E724-33 pubmed publisher
    ..Together, these results provide evidence that E2 modulates myosin pRLC in skeletal muscle and is one mechanism by which this hormone can affect muscle contractility in females. ..
  56. La Sala G, Farini D, De Felici M. Rapid estrogen signalling in mouse primordial germ cells. Exp Cell Res. 2010;316:1716-27 pubmed publisher
  57. Broughton B, Brait V, Guida E, Lee S, Arumugam T, Gardiner Mann C, et al. Stroke increases g protein-coupled estrogen receptor expression in the brain of male but not female mice. Neurosignals. 2013;21:229-39 pubmed publisher
    The novel estrogen receptor, G protein-coupled estrogen receptor (GPER, previously named GPR30), is widely distributed throughout the male and female brain and, thus, could potentially play a role in estrogen-mediated neuroprotective ..
  58. Li Y, Ren C, Zhang Q, Li J, Chian R. Expression of G protein estrogen receptor (GPER) on membrane of mouse oocytes during maturation. J Assist Reprod Genet. 2013;30:227-32 pubmed publisher
    ..of oocytes, in vivo and in vitro matured oocytes as well as aging oocytes was examined by immune-fluorescence GPR30 antibody and the images were analyzed by laser scanning confocal microscope...
  59. Kumar A, Bean L, Rani A, Jackson T, Foster T. Contribution of estrogen receptor subtypes, ER?, ER?, and GPER1 in rapid estradiol-mediated enhancement of hippocampal synaptic transmission in mice. Hippocampus. 2015;25:1556-66 pubmed publisher
    ..Furthermore, EB was able to increase ERK activity regardless of genotype. These results suggest that ERK activation and enhancement of synaptic transmission by EB involves multiple estrogen receptor subtypes. ..
  60. Delbeck M, Golz S, Vonk R, Janssen W, Hucho T, Isensee J, et al. Impaired left-ventricular cardiac function in male GPR30-deficient mice. Mol Med Rep. 2011;4:37-40 pubmed publisher
    G-protein-coupled receptor 30 (GPR30) has been reported to act as a membrane-bound estrogen receptor that is involved in the mediation of non-genomic estradiol signalling...
  61. Schackmann R, van Amersfoort M, Haarhuis J, Vlug E, Halim V, Roodhart J, et al. Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance. J Clin Invest. 2011;121:3176-88 pubmed publisher
  62. Kajta M, Litwa E, Rzemieniec J, Wnuk A, Lason W, Zelek Molik A, et al. Isomer-nonspecific action of dichlorodiphenyltrichloroethane on aryl hydrocarbon receptor and G-protein-coupled receptor 30 intracellular signaling in apoptotic neuronal cells. Mol Cell Endocrinol. 2014;392:90-105 pubmed publisher
    ..It also provided evidence for DDT-isomer-nonspecific alterations of AhR- and GPR30-mediated intracellular signaling, including changes in the levels of the receptor and receptor-regulated mRNAs, ..
  63. Meoli L, Isensee J, Zazzu V, Nabzdyk C, Soewarto D, Witt H, et al. Sex- and age-dependent effects of Gpr30 genetic deletion on the metabolic and cardiovascular profiles of diet-induced obese mice. Gene. 2014;540:210-6 pubmed publisher
    The G protein-coupled receptor 30 (GPR30) has been claimed as an estrogen receptor. However, the literature reports controversial findings and the physiological function of GPR30 is not fully understood yet...
  64. Liu S, Zhang N, Guo Y, Zhao R, Shi T, Feng S, et al. G-protein-coupled receptor 30 mediates rapid neuroprotective effects of estrogen via depression of NR2B-containing NMDA receptors. J Neurosci. 2012;32:4887-900 pubmed publisher
    ..receptors involved remain unclear, even though studies have suggested that estrogen G-protein-coupled receptor 30 (GPR30) is linked to protection against ischemic injury...
  65. Liu S, Tian Z, Guo Y, Zhang N, Feng B, Zhao M. Activation of GPR30 attenuates chronic pain-related anxiety in ovariectomized mice. Psychoneuroendocrinology. 2015;53:94-107 pubmed publisher
    ..We found that the level of G-protein-coupled receptor 30 (GPR30), a membrane estrogen receptor, was significantly increased in the basolateral amygdala (BLA) of ovariectomized (OVX) mice suffering ..
  66. Kabir M, Singh H, Lu R, Olde B, Leeb Lundberg L, Bopassa J. G Protein-Coupled Estrogen Receptor 1 Mediates Acute Estrogen-Induced Cardioprotection via MEK/ERK/GSK-3β Pathway after Ischemia/Reperfusion. PLoS ONE. 2015;10:e0135988 pubmed publisher
  67. Li Y, Xu J, Jiang F, Jiang Z, Liu C, Li L, et al. G protein-coupled estrogen receptor is involved in modulating colonic motor function via nitric oxide release in C57BL/6 female mice. Neurogastroenterol Motil. 2016;28:432-42 pubmed publisher
    ..Here, we investigated whether G protein-coupled estrogen receptor (GPER/GPR30) was involved in regulating colonic motor functions and explored the underlying physiological mechanisms...
  68. Engdahl C, Jochems C, Windahl S, Börjesson A, Ohlsson C, Carlsten H, et al. Amelioration of collagen-induced arthritis and immune-associated bone loss through signaling via estrogen receptor alpha, and not estrogen receptor beta or G protein-coupled receptor 30. Arthritis Rheum. 2010;62:524-33 pubmed publisher
    ..The purpose of this study was to elucidate the ER specificity for the ameliorating effects of estrogen on arthritis and bone loss in a model of postmenopausal rheumatoid arthritis (RA)...
  69. Chimento A, Sirianni R, Casaburi I, Ruggiero C, Maggiolini M, Ando S, et al. 17?-Estradiol activates GPER- and ESR1-dependent pathways inducing apoptosis in GC-2 cells, a mouse spermatocyte-derived cell line. Mol Cell Endocrinol. 2012;355:49-59 pubmed publisher
    ..17?-Estradiol (E2) in primary rat pachytene spermatocytes (PS) binds estrogen receptor ? (ESR1) and GPER to activate EGFR/ERK/c-Jun pathway leading to up regulation of proapoptotic factor bax...