Fyn

Summary

Gene Symbol: Fyn
Description: Fyn proto-oncogene
Alias: AI448320, AW552119, tyrosine-protein kinase Fyn, Src Kinase p59, p59-Fyn, proto-oncogene c-Fyn, proto-oncogene tyrosine-protein kinase Fyn
Species: mouse
Products:     Fyn

Top Publications

  1. Umemori H, Sato S, Yagi T, Aizawa S, Yamamoto T. Initial events of myelination involve Fyn tyrosine kinase signalling. Nature. 1994;367:572-6 pubmed
    ..Among these proteins, we identified Fyn tyrosine kinase, one of the non-receptor-type tyrosine kinases of the Src family...
  2. Nada S, Shima T, Yanai H, Husi H, Grant S, Okada M, et al. Identification of PSD-93 as a substrate for the Src family tyrosine kinase Fyn. J Biol Chem. 2003;278:47610-21 pubmed
    ..Recombinant PSD-93 was phosphorylated by Fyn in vitro, and Tyr-384 was identified as a major phosphorylation site...
  3. Nakazawa T, Komai S, Tezuka T, Hisatsune C, Umemori H, Semba K, et al. Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor. J Biol Chem. 2001;276:693-9 pubmed
    ..Tyrosine phosphorylation of NMDA receptors by Src-family tyrosine kinases such as Fyn is implicated in synaptic plasticity...
  4. Cooke M, Perlmutter R. Expression of a novel form of the fyn proto-oncogene in hematopoietic cells. New Biol. 1989;1:66-74 pubmed
    The fyn proto-oncogene encodes a 59-kD membrane-associated protein-tyrosine kinase that is implicated in the control of cell growth...
  5. Stein P, Vogel H, Soriano P. Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice. Genes Dev. 1994;8:1999-2007 pubmed
    Three members of the Src family of tyrosine kinases, src, fyn, and yes, are broadly expressed throughout mouse development...
  6. Horikawa K, Nishizumi H, Umemori H, Aizawa S, Takatsu K, Yamamoto T. Distinctive roles of Fyn and Lyn in IgD- and IgM-mediated signaling. Int Immunol. 1999;11:1441-9 pubmed
    Src family kinases Fyn and Lyn associate with the B cell antigen receptor (BCR). Accumulating data show that Lyn plays important roles in BCR-mediated signaling, while the role of Fyn remains obscure...
  7. Kojima N, Ishibashi H, Obata K, Kandel E. Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice. Learn Mem. 1998;5:429-45 pubmed
    Earlier work has suggested that Fyn tyrosine kinase plays an important role in synaptic plasticity...
  8. Bhandari V, Lim K, Pallen C. Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn. J Biol Chem. 1998;273:8691-8 pubmed
    We have examined the in vivo activity of receptor-like protein-tyrosine phosphatase alpha (PTPalpha) toward p59(fyn), a widely expressed Src family kinase...
  9. Babus L, Little E, Keenoy K, Minami S, Chen E, Song J, et al. Decreased dendritic spine density and abnormal spine morphology in Fyn knockout mice. Brain Res. 2011;1415:96-102 pubmed publisher
    b>Fyn is a Src-family tyrosine kinase that affects long term potentiation (LTP), synapse formation, and learning and memory. Fyn is also implicated in dendritic spine formation both in vitro and in vivo...

More Information

Publications85

  1. McGinnis L, Kinsey W, Albertini D. Functions of Fyn kinase in the completion of meiosis in mouse oocytes. Dev Biol. 2009;327:280-7 pubmed publisher
    ..The Src-family kinases FYN, YES and SRC are expressed in mammalian oocytes but their function during oocyte maturation remains an open ..
  2. Kuo G, Arnaud L, Kronstad O Brien P, Cooper J. Absence of Fyn and Src causes a reeler-like phenotype. J Neurosci. 2005;25:8578-86 pubmed
    ..Biochemical and in vitro experiments implicate Src and Fyn in the Reelin-dependent tyrosine phosphorylation of Dab1, which controls the positioning of radially migrating ..
  3. Goto J, Tezuka T, Nakazawa T, Tsukamoto N, Nakamura T, Ajima R, et al. Altered gene expression in the adult brain of fyn-deficient mice. Cell Mol Neurobiol. 2004;24:149-59 pubmed
    1. Fyn, a member of Src-family tyrosine kinases, is implicated in both brain development and adult brain function...
  4. Klein C, Kramer E, Cardine A, Schraven B, Brandt R, Trotter J. Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau. J Neurosci. 2002;22:698-707 pubmed
    b>Fyn kinase plays an important role during myelination and has been shown to promote morphological differentiation of cultured oligodendrocytes. We analyzed the downstream targets of Fyn kinase in oligodendrocytes...
  5. Latour S, Roncagalli R, Chen R, Bakinowski M, Shi X, Schwartzberg P, et al. Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation. Nat Cell Biol. 2003;5:149-54 pubmed
    ..These observations characterize a biologically important signalling mechanism in which an adaptor molecule composed only of an SH2 domain links a receptor devoid of intrinsic catalytic activity to the kinase required for its function. ..
  6. Liu G, Beggs H, Jurgensen C, Park H, Tang H, Gorski J, et al. Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction. Nat Neurosci. 2004;7:1222-32 pubmed
    ..induces tyrosine phosphorylation of proteins including focal adhesion kinase (FAK) and the Src family kinase Fyn. Blockers of Src family kinases inhibited FAK phosphorylation and axon outgrowth and attraction by netrin...
  7. Williamson R, Usardi A, Hanger D, Anderton B. Membrane-bound beta-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism. FASEB J. 2008;22:1552-9 pubmed
    ..In addition, our data from fyn(-/-) transgenic mice show that accumulation of Abeta on the neuronal surface was not sufficient to cause cell death ..
  8. Cooke M, Abraham K, Forbush K, Perlmutter R. Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn). Cell. 1991;65:281-91 pubmed
    ..Our results suggest that p59fyn is a critically important component of the TCR signal transduction apparatus. ..
  9. Santuccione A, Sytnyk V, Leshchyns ka I, Schachner M. Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth. J Cell Biol. 2005;169:341-54 pubmed
    ..NCAM at the neuronal surface and PrP promote recruitment of NCAM to lipid rafts and thereby regulate activation of fyn kinase, an enzyme involved in NCAM-mediated signaling...
  10. Eberl G, Lowin Kropf B, MacDonald H. Cutting edge: NKT cell development is selectively impaired in Fyn- deficient mice. J Immunol. 1999;163:4091-4 pubmed
    ..Here, we show that the Src protein tyrosine kinase Fyn is required for development of CD1d-dependent NKT cells but not for the development of conventional T cells...
  11. Davidson D, Viallet J, Veillette A. Unique catalytic properties dictate the enhanced function of p59fynT, the hemopoietic cell-specific isoform of the Fyn tyrosine protein kinase, in T cells. Mol Cell Biol. 1994;14:4554-64 pubmed
    As a result of alternative splicing, the fyn gene encodes two different tyrosine protein kinase isoforms...
  12. Dong Z, Davidson D, Pérez Quintero L, Kurosaki T, Swat W, Veillette A. The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells. Immunity. 2012;36:974-85 pubmed publisher
    ..SAP enhanced NK cell responsiveness by a dual molecular mechanism. It coupled SLAM family receptors to the kinase Fyn, which triggered the exchange factor Vav-1 and augmented NK cell activation...
  13. Kojima N, Wang J, Mansuy I, Grant S, Mayford M, Kandel E. Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene. Proc Natl Acad Sci U S A. 1997;94:4761-5 pubmed
    To examine the physiological role of the Fyn tyrosine kinase in neurons, we generated transgenic mice that expressed a fyn cDNA under the control of the calcium/calmodulin-dependent protein kinase IIalpha promoter...
  14. Levi M, Maro B, Shalgi R. Fyn kinase is involved in cleavage furrow ingression during meiosis and mitosis. Reproduction. 2010;140:827-34 pubmed publisher
    ..Several lines of evidence in somatic cells imply the involvement of Fyn, an Src family kinase (SFK), in cell cycle control and actin functions...
  15. Sandilands E, Brunton V, Frame M. The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements. J Cell Sci. 2007;120:2555-64 pubmed
    ..We show here that although two other ubiquitous Src family kinases (SFKs) Yes and Fyn also require intact actin filaments for peripheral membrane targeting, they display distinct spatial activation and ..
  16. Parravicini V, Gadina M, Kovarova M, Odom S, Gonzalez Espinosa C, Furumoto Y, et al. Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat Immunol. 2002;3:741-8 pubmed
    ..We report here that Fc epsilon RI also uses a Fyn kinase-dependent pathway that does not require Lyn kinase or the adapter LAT for its initiation, but is necessary ..
  17. Sperber B, Boyle Walsh E, Engleka M, Gadue P, Peterson A, Stein P, et al. A unique role for Fyn in CNS myelination. J Neurosci. 2001;21:2039-47 pubmed
    We analyzed the role of Fyn tyrosine kinase in CNS myelination by using fyn(-/-) null mutant mice, which express no Fyn protein. We found a severe myelin deficit in forebrain at all ages from 14 d to 1 year...
  18. Bock H, Herz J. Reelin activates SRC family tyrosine kinases in neurons. Curr Biol. 2003;13:18-26 pubmed
    ..Increased Dab1 protein expression in fyn-deficient mice implies a response to impaired Reelin signaling that is also observed in mice lacking Reelin or its ..
  19. Gadue P, Morton N, Stein P. The Src family tyrosine kinase Fyn regulates natural killer T cell development. J Exp Med. 1999;190:1189-96 pubmed
    T lymphocytes express two Src tyrosine kinases, Lck and Fyn. While thymocyte and T cell subsets are largely normal in fyn(-/-) mice, animals lacking Lck have impaired T cell development...
  20. Grant S, Karl K, Kiebler M, Kandel E. Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice. Genes Dev. 1995;9:1909-21 pubmed
    ..Comparison of fyn, src, yes, and abl nonreceptor tyrosine kinase mutant mice shows a specific requirement for Fyn in the induction of ..
  21. Seddon B, Zamoyska R. TCR signals mediated by Src family kinases are essential for the survival of naive T cells. J Immunol. 2002;169:2997-3005 pubmed
    ..Here we examine the role of the Src family kinases, p56(lck) (Lck) and p59(fyn) (Fyn), in the survival of naive T cells...
  22. Alexandropoulos K, Cheng G, Baltimore D. Proline-rich sequences that bind to Src homology 3 domains with individual specificities. Proc Natl Acad Sci U S A. 1995;92:3110-4 pubmed
    ..The SH3 domains of the Src-related kinases Fyn, Lyn, and Hck bind to this sequence with the same affinity as that of the Src SH3...
  23. Laird R, Hayes S. Profiling of the early transcriptional response of murine gammadelta T cells following TCR stimulation. Mol Immunol. 2009;46:2429-38 pubmed publisher
  24. Cannons J, Wu J, Gomez Rodriguez J, Zhang J, Dong B, Liu Y, et al. Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation. J Immunol. 2010;185:2819-27 pubmed publisher
    Signaling lymphocytic activation molecule-associated protein (SAP), an adaptor molecule that recruits Fyn to the signaling lymphocytic activation molecule (SLAM) family of immunomodulatory receptors, is mutated in X-linked ..
  25. Kitazawa H, Yagi T, Miyakawa T, Niki H, Kawai N. Abnormal synaptic transmission in the olfactory bulb of Fyn-kinase-deficient mice. J Neurophysiol. 1998;79:137-42 pubmed
    We studied synaptic transmission in the granule cells in the olfactory bulb of the homozygous Fyn (a nonreceptor type tyrosine kinase)-deficient (fynz/fynz) and heterozygous Fyn-deficient (+/fynz) mice by using slice preparations from ..
  26. Davidson D, Schraven B, Veillette A. PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes. Mol Cell Biol. 2007;27:1960-73 pubmed
    ..These data improve our comprehension of the function of PAG in T cells. They also further implicate FynT in T-cell anergy. ..
  27. Lovatt M, Filby A, Parravicini V, Werlen G, Palmer E, Zamoyska R. Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response. Mol Cell Biol. 2006;26:8655-65 pubmed
    The src family kinases p56lck (Lck) and p59fyn (Fyn) are the most proximal signaling molecules to be activated downstream of the T-cell receptor...
  28. Samayawardhena L, Kapur R, Craig A. Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells. Blood. 2007;109:3679-86 pubmed
    ..In this study, we investigated how Fyn kinase regulates chemotaxis of mast cells toward SCF...
  29. Grant S, O Dell T, Karl K, Stein P, Soriano P, Kandel E. Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science. 1992;258:1903-10 pubmed
    Mice with mutations in four nonreceptor tyrosine kinase genes, fyn, src, yes, and abl, were used to study the role of these kinases in long-term potentiation (LTP) and in the relation of LTP to spatial learning and memory...
  30. Bodrikov V, Leshchyns ka I, Sytnyk V, Overvoorde J, den Hertog J, Schachner M. RPTPalpha is essential for NCAM-mediated p59fyn activation and neurite elongation. J Cell Biol. 2005;168:127-39 pubmed
  31. Sun X, Pons S, Asano T, Myers M, Glasheen E, White M. The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation. J Biol Chem. 1996;271:10583-7 pubmed
    ..By comparison with the insulin receptor, p59fyn kinase phosphorylated a unique cohort of tyrosine residues in Irs-1. These results outline a role for p59fyn or other related Src-kinases during insulin and cytokine signaling. ..
  32. Doki N, Kitaura J, Uchida T, Inoue D, Kagiyama Y, Togami K, et al. Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models. Int J Hematol. 2012;95:167-75 pubmed publisher
    ..In contrast, it has been reported that Fyn is up-regulated in human CML-BC compared with CML-CP, implicating Fyn in the blast crisis transition...
  33. Arnaud L, Ballif B, Forster E, Cooper J. Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development. Curr Biol. 2003;13:9-17 pubmed
    ..We found that fyn is required for proper Dab1 levels and phosphorylation in vivo and in vitro...
  34. Wang J, Carnicella S, Phamluong K, Jeanblanc J, Ronesi J, Chaudhri N, et al. Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior. J Neurosci. 2007;27:3593-602 pubmed
    ..increase in the phosphorylation of the NR2B subunit of the NMDAR, and a corresponding increase in the activity of Fyn kinase, which phosphorylates NR2B...
  35. Yagi T, Aizawa S, Tokunaga T, Shigetani Y, Takeda N, Ikawa Y. A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice. Nature. 1993;366:742-5 pubmed
    Non-receptor-type tyrosine kinases of the Src family, such as Src, Yes and Fyn, are strongly expressed in the brain and have been suggested to have an important function in the central nervous system...
  36. Yasue T, Nishizumi H, Aizawa S, Yamamoto T, Miyake K, Mizoguchi C, et al. A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5. Proc Natl Acad Sci U S A. 1997;94:10307-12 pubmed
    ..B cells from fyn-deficient (Fyn-/-) and lyn-deficient (Lyn-/-) mice showed an impaired response to mAb CS/2 for proliferation and IL-..
  37. Reddy K, Smith D, Plow E. Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling. J Cell Sci. 2008;121:1641-8 pubmed publisher
    ..Here, we analyzed the interactions and functional consequences of Fyn and Src binding to alphaIIbbeta3...
  38. Davidson D, Shi X, Zhang S, Wang H, Nemer M, Ono N, et al. Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation. Immunity. 2004;21:707-17 pubmed
    ..These data imply that SAP is necessary for T(H)2 cytokine regulation primarily as a result of its capacity to recruit FynT. They also establish a previously unappreciated role for FynT in SAP-dependent T(H)2 cytokine regulation. ..
  39. Eliceiri B, Paul R, Schwartzberg P, Hood J, Leng J, Cheresh D. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell. 1999;4:915-24 pubmed
    ..angiogenesis, mice deficient in pp60c-src or pp62c-yes showed no VEGF-induced vascular permeability (VP), yet fyn-/- mice displayed normal VP. In contrast, inflammation-mediated VP appeared normal in Src-deficient mice...
  40. Calautti E, Missero C, Stein P, Ezzell R, Dotto G. fyn tyrosine kinase is involved in keratinocyte differentiation control. Genes Dev. 1995;9:2279-91 pubmed
    ..A second tyrosine kinase activity is induced in response to both calcium and TPA, and has been identified as fyn, a nonreceptor tyrosine kinase of the src family...
  41. Ilic D, Kanazawa S, Nishizumi H, Aizawa S, Kuroki T, Mori S, et al. Skin abnormality in aged fyn-/- fak+/- mice. Carcinogenesis. 1997;18:1473-6 pubmed
    ..Its association with Fyn, a member of the Src family of tyrosine kinases, has been observed in cell lines...
  42. Filipp D, Zhang J, Leung B, Shaw A, Levin S, Veillette A, et al. Regulation of Fyn through translocation of activated Lck into lipid rafts. J Exp Med. 2003;197:1221-7 pubmed
    Whether or how the activation of Lck and Fyn during T cell receptor (TCR) signaling is coordinated, and their delivery of function integrated, is unknown...
  43. Latour S, Gish G, Helgason C, Humphries R, Pawson T, Veillette A. Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product. Nat Immunol. 2001;2:681-90 pubmed
    ..They also provide insights into the pathophysiology of a severe human lymphoproliferative disease. ..
  44. Zikherman J, Jenne C, Watson S, Doan K, Raschke W, Goodnow C, et al. CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity. 2010;32:342-54 pubmed publisher
    ..Csk and CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn. T cell receptor (TCR) signaling and thymic development require CD45 expression but proceed constitutively in the ..
  45. HOE H, Minami S, Makarova A, Lee J, Hyman B, Matsuoka Y, et al. Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing. J Biol Chem. 2008;283:6288-99 pubmed
    ..mechanism underlying these alterations in processing and trafficking of APP and apoEr2, we examined the effect of Fyn, an Src family-tyrosine kinase known to interact with and phosphorylate Dab1...
  46. Utting O, Teh S, Teh H. T cells expressing receptors of different affinity for antigen ligands reveal a unique role for p59fyn in T cell development and optimal stimulation of T cells by antigen. J Immunol. 1998;160:5410-9 pubmed
    Signaling from the TCR involves the protein tyrosine kinase p59fyn (Fyn). Previous studies have shown that T cell development occurs normally in Fyn-/- mice...
  47. Page S, van Oers N, Perlmutter R, Weiss A, Pullen A. Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development. Eur J Immunol. 1997;27:554-62 pubmed
    ..We used mice deficient in Lck, Fyn, or both Lck and Fyn to analyze the role that these src-family PTK play in IEL development...
  48. Groves T, Smiley P, Cooke M, Forbush K, Perlmutter R, Guidos C. Fyn can partially substitute for Lck in T lymphocyte development. Immunity. 1996;5:417-28 pubmed
    ..One candidate is Fyn, a Src kinase coexpressed with Lck in immature and mature T cells...
  49. Beggs H, Baragona S, Hemperly J, Maness P. NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn). J Biol Chem. 1997;272:8310-9 pubmed
    ..Neurite outgrowth mediated by the neural cell adhesion molecule (NCAM) requires the src family tyrosine kinase p59(fyn) in nerve growth cones, but the molecular basis for this interaction has not been defined...
  50. Quek L, Pasquet J, Hers I, Cornall R, Knight G, Barnes M, et al. Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway. Blood. 2000;96:4246-53 pubmed
    ..In the current study, the role of 2 Src family kinases, Fyn and Lyn, in GPVI signaling has been examined using murine platelets deficient in one or both kinases...
  51. Vacaresse N, Møller B, Danielsen E, Okada M, Sap J. Activation of c-Src and Fyn kinases by protein-tyrosine phosphatase RPTPalpha is substrate-specific and compatible with lipid raft localization. J Biol Chem. 2008;283:35815-24 pubmed publisher
    ..We studied how RPTPalpha affects substrate specificity and regulation of c-Src and Fyn in response to epidermal growth factor and platelet-derived growth factor...
  52. Appleby M, Gross J, Cooke M, Levin S, Qian X, Perlmutter R. Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. Cell. 1992;70:751-63 pubmed
    ..These data confirm that p59fynT plays a pivotal role in TCR signal transduction and demonstrate that additional developmentally regulated signaling components also contribute to TCR-induced lymphocyte activation. ..
  53. Klinghoffer R, Sachsenmaier C, Cooper J, Soriano P. Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 1999;18:2459-71 pubmed
    ..We have generated mouse embryos harboring functional null mutations of the ubiquitously expressed SFKs Src, Yes and Fyn. This triple mutation leads to severe developmental defects and lethality by E9.5...
  54. Chan B, Lanyi A, Song H, Griesbach J, Simarro Grande M, Poy F, et al. SAP couples Fyn to SLAM immune receptors. Nat Cell Biol. 2003;5:155-60 pubmed
    ..The crystal structure of a ternary SLAM-SAP-Fyn-SH3 complex reveals that SAP binds the FynT SH3 domain through a surface-surface interaction that does not involve ..
  55. Mamchak A, Sullivan B, Hou B, Lee L, Gilden J, Krummel M, et al. Normal development and activation but altered cytokine production of Fyn-deficient CD4+ T cells. J Immunol. 2008;181:5374-85 pubmed
    The Src family kinase Fyn is expressed in T cells and has been shown to phosphorylate proteins involved in TCR signaling, cytoskeletal reorganization, and IL-4 production...
  56. Levi M, Maro B, Shalgi R. The involvement of Fyn kinase in resumption of the first meiotic division in mouse oocytes. Cell Cycle. 2010;9:1577-89 pubmed
    ..Previous studies suggest a role for Fyn, a non-receptor Src family tyrosine kinase, in the exit from MII arrest...
  57. Kudlacz E, Andresen C, Salafia M, Whitney C, Naclerio B, Changelian P. Genetic ablation of the src kinase p59fynT exacerbates pulmonary inflammation in an allergic mouse model. Am J Respir Cell Mol Biol. 2001;24:469-74 pubmed
    ..Overall, these data demonstrate fyn is a negative regulator of allergic airway inflammation in mice because its absence promotes a shift to a T helper-..
  58. Stein P, Lee H, Rich S, Soriano P. pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell. 1992;70:741-50 pubmed
    ..b>fyn- mice did not display an overt phenotype...
  59. Cannons J, Yu L, Jankovic D, Crotty S, Horai R, Kirby M, et al. SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation. J Exp Med. 2006;203:1551-65 pubmed
    X-linked lymphoproliferative disease is caused by mutations affecting SH2D1A/SAP, an adaptor that recruits Fyn to signal lymphocyte activation molecule (SLAM)-related receptors...
  60. Appleby M, Kerner J, Chien S, Maliszewski C, Bondada S, Perlmutter R, et al. Involvement of p59fynT in interleukin-5 receptor signaling. J Exp Med. 1995;182:811-20 pubmed
    ..Our results document the importance of p59fynT in IL-5 responses in B cells, and they support a general model for cytokine receptor signal transduction involving the simultaneous recruitment of at least three families of PTK. ..
  61. Huang J, Tilly D, Altman A, Sugie K, Grey H. T-cell receptor antagonists induce Vav phosphorylation by selective activation of Fyn kinase. Proc Natl Acad Sci U S A. 2000;97:10923-9 pubmed
    ..In this study, we investigated the role played by the protein tyrosine kinases Fyn, Lck, and ZAP-70 in antagonist-induced signaling pathway...
  62. Filipp D, Moemeni B, Ferzoco A, Kathirkamathamby K, Zhang J, Ballek O, et al. Lck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid rafts. J Biol Chem. 2008;283:26409-22 pubmed publisher
    Mechanisms regulating the activation and delivery of function of Lck and Fyn are central to the generation of the most proximal signaling events emanating from the T cell antigen receptor (TcR) complex...
  63. Tezuka T, Umemori H, Akiyama T, Nakanishi S, Yamamoto T. PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. Proc Natl Acad Sci U S A. 1999;96:435-40 pubmed
    b>Fyn, a member of the Src-family protein-tyrosine kinase (PTK), is implicated in learning and memory that involves N-methyl-D-aspartate (NMDA) receptor function...
  64. van Oers N, Lowin Kropf B, Finlay D, Connolly K, Weiss A. alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity. 1996;5:429-36 pubmed
    ..Here we show that the combined disruption of Lck and Fyn (lck(-/-)fyn(-/-)) completely arrests alpha beta T cell development at the CD4-CD8- stage...
  65. Sette C, Paronetto M, Barchi M, Bevilacqua A, Geremia R, Rossi P. Tr-kit-induced resumption of the cell cycle in mouse eggs requires activation of a Src-like kinase. EMBO J. 2002;21:5386-95 pubmed
    ..We show that the Src-like kinase Fyn phosphorylates Tyr161 in tr-kit and that this residue is essential for tr-kit function...
  66. Lu Z, Ku L, Chen Y, Feng Y. Developmental abnormalities of myelin basic protein expression in fyn knock-out brain reveal a role of Fyn in posttranscriptional regulation. J Biol Chem. 2005;280:389-95 pubmed
    b>Fyn protein-tyrosine kinase (PTK), a member of the Src-PTK family, is essential for myelin development in the central nervous system (CNS)...
  67. Relucio J, Tzvetanova I, Ao W, Lindquist S, Colognato H. Laminin alters fyn regulatory mechanisms and promotes oligodendrocyte development. J Neurosci. 2009;29:11794-806 pubmed publisher
    ..differentiation was Src family kinase-dependent and resulted in the activation of the Src family kinase Fyn. In laminin-deficient brains, however, increased Fyn repression was accompanied by elevated levels of the Src ..
  68. Ittner L, Ke Y, Delerue F, Bi M, Gladbach A, van Eersel J, et al. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell. 2010;142:387-97 pubmed publisher
    ..we show that tau, known as axonal protein, has a dendritic function in postsynaptic targeting of the Src kinase Fyn, a substrate of which is the NMDA receptor (NR)...
  69. Bastie C, Zong H, Xu J, Busa B, Judex S, Kurland I, et al. Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn. Cell Metab. 2007;5:371-81 pubmed
    Mice null for Fyn (a member of the Src family of nonreceptor tyrosine kinases) display a reduced percentage of adipose mass associated with decreased adipocyte cell size...
  70. Shima T, Nada S, Okada M. Transmembrane phosphoprotein Cbp senses cell adhesion signaling mediated by Src family kinase in lipid rafts. Proc Natl Acad Sci U S A. 2003;100:14897-902 pubmed
    ..The results obtained by using mutant mice or cells that lack Csk and/or a member of SFK, Fyn, reveal that Cbp is phosphorylated predominantly by raft-localized Fyn in vivo...
  71. Seddon B, Tomlinson P, Zamoyska R. Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat Immunol. 2003;4:680-6 pubmed
    ..Thus, IL-7 contributes to the maintenance of all naive and memory T cell subsets, and therefore controls the overall size of the T cell pool. ..
  72. Yamada E, Pessin J, Kurland I, Schwartz G, Bastie C. Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1. Cell Metab. 2010;11:113-24 pubmed publisher
    b>Fyn null mice display reduced adiposity associated with increased fatty acid oxidation, energy expenditure, and activation of the AMP-dependent protein kinase (AMPK) in skeletal muscle and adipose tissue...
  73. Minami S, HOE H, Rebeck G. Fyn kinase regulates the association between amyloid precursor protein and Dab1 by promoting their localization to detergent-resistant membranes. J Neurochem. 2011;118:879-90 pubmed publisher
    ..interacts with amyloid precursor protein (APP) and decreases its pathological processing, an effect mediated by Fyn tyrosine kinase. Fyn is highly enriched in lipid rafts, a major site of pathological APP processing...
  74. Mason L, Willette Brown J, Taylor L, McVicar D. Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45. J Immunol. 2006;176:6615-23 pubmed
    ..1) inhibition of Src family kinases suppresses DAP12 phosphorylation and downstream DAP12 signals; 2) both Fyn and Lck are capable of phosphorylating DAP12; and 3) both kinases coimmunoprecipitate with the Ly-49D/DAP12 complex ..
  75. Cabodi S, Calautti E, Talora C, Kuroki T, Stein P, Dotto G. A PKC-eta/Fyn-dependent pathway leading to keratinocyte growth arrest and differentiation. Mol Cell. 2000;6:1121-9 pubmed
    Growth control of epithelial cells differs substantially from other cell types. Activation of Fyn, a Src kinase family member, is required for normal keratinocyte differentiation...
  76. Miyakawa T, Yagi T, Kitazawa H, Yasuda M, Kawai N, Tsuboi K, et al. Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. Science. 1997;278:698-701 pubmed
    ..In order to identify possible responsible genes, mice lacking Fyn, a non-receptor type tyrosine kinase, were investigated...