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Genomes and Genes
| Fut7SummaryGene Symbol: Fut7 Description: fucosyltransferase 7 Alias: AI853193, FTVII, Fuc-TVII, FucT-VII, alpha-(1,3)-fucosyltransferase, fucosyltransferase VII, galactoside 3-L-fucosyltransferase Species: mouse Top Publications
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Publications
The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homingJ W Homeister
Howard Hughes Medical Institute, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
Immunity 15:115-26. 2001..These observations reveal essential FucT-IV-dependent contributions to E-, P-, and L-selectin ligand synthesis and to the control of leukocyte recruitment and lymphocyte homing...- The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesisP Maly
Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor 48109 0650, USA
Cell 86:643-53. 1996..These observations demonstrate an essential role for Fuc-TVII in E-, P-, and L-selectin ligand biosynthesis and imply that this locus can control leukocyte trafficking in health and disease... - Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvesselsW Weninger
The Center for Blood Research and Department of Pathology, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Immunity 12:665-76. 2000..These results demonstrate a role for FucT-IV in selectin-dependent adhesion and suggest that the endothelial selectins and FucTs have distinct but overlapping functions in the immunosurveillance of the skin... - Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivoKerstin Siegmund
Experimentelle Rheumatologie, Charité Universit aetsmedizin Berlin, c o DRFZ, Schumannstr 21 22, 10117 Berlin, Germany
Blood 106:3097-104. 2005..Here, by using alpha(E)+ effector/memory-like Tregs from fucosyltransferase VII-deficient animals, which lack E/P-selectin ligands and fail to migrate into inflamed sites, we analyzed .. - Fucosyltransferase VII-deficient mice with defective E-, P-, and L-selectin ligands show impaired CD4+ and CD8+ T cell migration into the skin, but normal extravasation into visceral organsIris Erdmann
Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland
J Immunol 168:2139-46. 2002..Mice deficient for alpha-1,3-fucosyltransferase VII (FucTVII)(-/-) are characterized by deficiency of E-, P-, and L-selectin ligand activity... - Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid aggregate high endothelial venules correlates with expression of L-selectin ligandsP L Smith
Howard Hughes Medical Institute, University of Michigan, Ann Arbor, 48109 0650, USA
J Biol Chem 271:8250-9. 1996..These observations suggest that Fuc-TVII participates in the generation of alpha(1,3)fucosylated ligands for L-selectin and provide further evidence for a role for this enzyme in E- and P-selectin ligand expression in leukocytes... - Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reactionCornelia Doebis
Départemente of Experimentelle Rheumatologie, Charite, Campus Mitte, Berlin, Germany
Am J Pathol 173:1067-76. 2008..However, only the presence of selectin ligands on T cells was critical for the inflammatory reaction. These findings reveal T cells as the predominant targets for selectin blockade that aim to suppress skin inflammation... - Foxp3+ regulatory T cells maintain immune homeostasis in the skinJan C Dudda
Benaroya Research Institute, Seattle, WA 98101, USA
J Exp Med 205:1559-65. 2008..with cells whose ability to migrate to the skin was impaired because of targeted mutation of alpha-1,3-fucosyltransferase VII (Fut7)... - Notch-dependent control of myelopoiesis is regulated by fucosylationLan Zhou
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
Blood 112:308-19. 2008.... - Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitisMadeliene E Gainers
Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 179:8509-18. 2007.... - Disruption of tissue-specific fucosyltransferase VII, an enzyme necessary for selectin ligand synthesis, suppresses atherosclerosis in miceJonathan M Gitlin
Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
Am J Pathol 174:343-50. 2009..In this study, we have determined the role of tissue-specific fucosyltransferase VII (FucT-VII), an enzyme necessary for selectin ligand synthesis, in the development of atherosclerosis... - Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune responseNan Zhang
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Immunity 30:458-69. 2009..These results showed that sequential migration from blood to the target tissue and to dLNs is required for Treg cells to differentiate and execute fully their suppressive function... - Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosisStefan Ehlers
Molecular Inflammation Medicine, Christian Albrechts Universitat, Kiel, Germany Microbial Inflammation Research, Research Center Borstel, Parkallee 1, 23845 Borstel, Borstel, Germany
Immunobiology 214:674-82. 2009..These results suggest that targeting selectin ligand function during treatment of chronic inflammatory disorders may run the risk of accelerating TB disease progression... - Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3P L Beck
Gastrointestinal Research Group, University of Calgary, Calgary, Alberta, Canada T2N 4N1
Am J Physiol Gastrointest Liver Physiol 299:G43-53. 2010Intestinal mucosal integrity is dependent on epithelial function and a regulated immune response to injury. Fucosyltransferase VII (Fuc-TVII) is an essential enzyme required for the expression of the functional ligand for E- and P-.. - Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4Xiaodong Jiang
Department of Dermatology, Harvard Skin Disease Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 107:7443-8. 2010..DETC were significantly reduced in CCR4(-/-) mice but were present at normal levels in CCR10(-/-) mice. Our results present evidence for the crucial role of trafficking molecules in embryonic migration of DETC precursors to skin... - Naïve T cells re-distribute to the lungs of selectin ligand deficient miceJohn R Harp
Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA
PLoS ONE 5:e10973. 2010..Selectin mediated binding also plays a key role in T cell entry to inflamed organs... - Novel anti-carbohydrate antibodies reveal the cooperative function of sulfated N- and O-glycans in lymphocyte homingJotaro Hirakawa
Laboratory of Microbiology and Immunology, and the Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
J Biol Chem 285:40864-78. 2010..Thus, the two mAbs generated by a novel method revealed the cooperative function of sulfated N- and O-glycans in lymphocyte homing and immune surveillance... - Memory T cells are enriched in lymph nodes of selectin-ligand-deficient miceJohn R Harp
Department of Microbiology, University of Tennessee, Knoxville, TN 37996, USA
J Immunol 185:5751-61. 2010..These results suggest that memory T cells are enriched in LNs with T cell deficits by several mechanisms, including longer T cell retention and increased homeostatic proliferation... - Functional contributions of N- and O-glycans to L-selectin ligands in murine and human lymphoid organsHanayo Arata-Kawai
Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
Am J Pathol 178:423-33. 2011..These findings extend the evidence for the importance of N-glycans in lymphocyte homing in mouse and indicate that this dependency also applies to human lymphoid organs... - The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphaticsLevi G Ledgerwood
Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
Nat Immunol 9:42-53. 2008..Thus, the increased sphingosine 1-phosphate present in inflamed peripheral tissues may induce T cell retention and suppress T cell egress... - Significant decrease in alpha1,3-linked fucose in association with increase in 6-sulfated N-acetylglucosamine in peripheral lymph node addressin of FucT-VII-deficient mice exhibiting diminished lymphocyte homingNobuyoshi Hiraoka
Glycobiology Program, Cancer Research Center, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
Glycobiology 17:277-93. 2007..These results combined together suggest that KSST competes with FucT-VII for the same acceptor substrate and downregulates the synthesis of L-selectin ligand by inhibiting alpha1,3-fucosylation... - Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heartYi Hong Cai
Vascular Research Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Immunol 176:6568-75. 2006..These results identify a prominent role for selectin ligands in contributing to effector CD8+ T cell recruitment into the myocardium and indicate that selectin-dependent T cell recruitment is relevant to other tissues besides the skin... - Mechanisms of NSAID-induced gastrointestinal injury defined using mutant miceP L Beck
Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Gastroenterology 119:699-705. 2000..We established a murine model of NSAID-induced gastrointestinal damage to assess the roles of candidate gene products in the pathogenesis of this injury... - Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodesG Smithson
Department of Pathology, The University of Michigan, Ann Arbor, Michigan 48109, USA
J Exp Med 194:601-14. 2001.... - Intercellular cell adhesion molecule-1 and selectin ligands in acute cardiac allograft rejection: a study on gene-deficient mouse modelsJiri Lacha
Department of Nephrology, Transplant Unit, Institute for Clinical and Experimental Medicine, Prague 4, Czech Republic
J Leukoc Biol 71:311-8. 2002.... - Pathophysiological contributions of fucosyltransferases in renal ischemia reperfusion injuryMelissa J Burne
Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Immunol 169:2648-52. 2002..Neutrophil infiltration in postischemic kidneys of FucT-IV/FucT-VII-deficient mice was also attenuated. These data demonstrate that fucosyltransferases are important in the pathogenesis of renal IRI and are potential therapeutic targets... - Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilumJason A Carlyon
Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8031, USA
Blood 102:3387-95. 2003..However, murine infection does not require neutrophil PSGL-1 expression, which has important implications for understanding how A phagocytophilum binds and infects neutrophils... - Arteriogenesis proceeds via ICAM-1/Mac-1- mediated mechanismsImo E Hoefer
Research Group for Experimental and Clinical Arteriogenesis at the Department of Cardiology, University of Freiburg, Freiburg, Germany
Circ Res 94:1179-85. 2004.... - Alpha(1,3)fucosyltransferases FucT-IV and FucT-VII control susceptibility to atherosclerosis in apolipoprotein E-/- miceJonathon W Homeister
Department of Pathology and The Howard Hughes Medical Institute, University of Michigan, M5240 Medical Science I, 1301 Catherine Street, Ann Arbor, MI 48109 0602, USA
Arterioscler Thromb Vasc Biol 24:1897-903. 2004..They also determine the functional contribution of FucT-IV and FucT-VII to shear-dependent tethering of monocytes to P-selectin, a process believed to be required for atherogenesis... - Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17Matthew A Stark
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
Immunity 22:285-94. 2005..Antibody blockade of the p40 subunit of IL-23 reduces neutrophil numbers in wild-type mice. These findings identify a major homeostatic mechanism for the regulation of neutrophil production in vivo... - Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VIILaura Piccio
Department of Pathology, University of Verona, Verona, Italy
J Immunol 174:5805-13. 2005..These observations allow us to conclude that efficient recruitment of activated lymphocytes to the brain in the contexts mimicking EAE is controlled by FucT-VII and its cognate cell surface Ag CLA... - Synthesis of {alpha}(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skinTakahiro Satoh
Department of Dermatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Am J Pathol 167:787-96. 2005.... - T-cell P/E-selectin ligand alpha(1,3)fucosylation is not required for graft-vs-host disease inductionHyeon Seok Eom
Transplantation Biology Research Center, Bone Marrow Transplantation Section, Massachusetts General Hospital Harvard Medical School, Boston, 02129, USA
Exp Hematol 33:1564-73. 2005..We hypothesized that Fuc-TIV(-/-)/Fuc-TVII(-/-) donor T cells might have reduced capacity to roll on vessels of inflamed target tissues and mediate graft-vs-host disease (GVHD)... - Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitmentShihao Chen
Glycobiology Program, Cancer Research Center, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
J Exp Med 202:1679-89. 2005..These findings indicate that L-selectin-mediated NK cell recruitment plays a crucial role in the control of tumor metastasis into secondary lymphoid organs... - Selectin ligand-independent priming and maintenance of T cell immunity during airborne tuberculosisTanja Schreiber
Junior Research Group Molecular Infection Biology, Research Center Borstel, Germany
J Immunol 176:1131-40. 2006.... - L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrestHeinz Laubli
Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Cancer Res 66:1536-42. 2006..These data provide the first explanation for how leukocyte L-selectin facilitates tumor metastasis... - Physiological contribution of CD44 as a ligand for E-Selectin during inflammatory T-cell recruitmentMaria Nacher
Department of Epidemiology, Atherothrombosis and Imaging, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain
Am J Pathol 178:2437-46. 2011..Our results identify additional mechanisms by which CD44 modulates the inflammatory response...