Fut7

Summary

Gene Symbol: Fut7
Description: fucosyltransferase 7
Alias: AI853193, FTVII, Fuc-TVII, FucT-VII, alpha-(1,3)-fucosyltransferase 7, fucosyltransferase VII, galactoside 3-L-fucosyltransferase
Species: mouse
Products:     Fut7

Top Publications

  1. Harp J, Onami T. Naïve T cells re-distribute to the lungs of selectin ligand deficient mice. PLoS ONE. 2010;5:e10973 pubmed publisher
    ..Re-distribution of T cells into organs could potentially play a role in the initiation of T cell mediated organ diseases. ..
  2. Harp J, Gilchrist M, Onami T. Memory T cells are enriched in lymph nodes of selectin-ligand-deficient mice. J Immunol. 2010;185:5751-61 pubmed publisher
    ..These results suggest that memory T cells are enriched in LNs with T cell deficits by several mechanisms, including longer T cell retention and increased homeostatic proliferation...
  3. Jiang X, Campbell J, Kupper T. Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4. Proc Natl Acad Sci U S A. 2010;107:7443-8 pubmed publisher
    ..DETC were significantly reduced in CCR4(-/-) mice but were present at normal levels in CCR10(-/-) mice. Our results present evidence for the crucial role of trafficking molecules in embryonic migration of DETC precursors to skin. ..
  4. Siegmund K, Feuerer M, Siewert C, Ghani S, Haubold U, Dankof A, et al. Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo. Blood. 2005;106:3097-104 pubmed
    ..Here, by using alpha(E)+ effector/memory-like Tregs from fucosyltransferase VII-deficient animals, which lack E/P-selectin ligands and fail to migrate into inflamed sites, we analyzed ..
  5. Weninger W, Ulfman L, Cheng G, Souchkova N, Quackenbush E, Lowe J, et al. Specialized contributions by alpha(1,3)-fucosyltransferase-IV and FucT-VII during leukocyte rolling in dermal microvessels. Immunity. 2000;12:665-76 pubmed
    ..These results demonstrate a role for FucT-IV in selectin-dependent adhesion and suggest that the endothelial selectins and FucTs have distinct but overlapping functions in the immunosurveillance of the skin. ..
  6. Maly P, Thall A, Petryniak B, Rogers C, Smith P, Marks R, et al. The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis. Cell. 1996;86:643-53 pubmed
    ..These observations demonstrate an essential role for Fuc-TVII in E-, P-, and L-selectin ligand biosynthesis and imply that this locus can control leukocyte trafficking in health and disease. ..
  7. Ehlers S, Schreiber T, Dunzendorfer A, Lowe J, Holscher C. Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis. Immunobiology. 2009;214:674-82 pubmed publisher
    ..These results suggest that targeting selectin ligand function during treatment of chronic inflammatory disorders may run the risk of accelerating TB disease progression. ..
  8. Erdmann I, Scheidegger E, Koch F, Heinzerling L, Odermatt B, Burg G, et al. Fucosyltransferase VII-deficient mice with defective E-, P-, and L-selectin ligands show impaired CD4+ and CD8+ T cell migration into the skin, but normal extravasation into visceral organs. J Immunol. 2002;168:2139-46 pubmed
    ..Mice deficient for alpha-1,3-fucosyltransferase VII (FucTVII)(-/-) are characterized by deficiency of E-, P-, and L-selectin ligand activity...
  9. Homeister J, Thall A, Petryniak B, Maly P, Rogers C, Smith P, et al. The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing. Immunity. 2001;15:115-26 pubmed
    ..These observations reveal essential FucT-IV-dependent contributions to E-, P-, and L-selectin ligand synthesis and to the control of leukocyte recruitment and lymphocyte homing. ..

More Information

Publications56

  1. Cai Y, Alvarez A, Alcaide P, Duramad P, Lim Y, Jarolim P, et al. Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart. J Immunol. 2006;176:6568-75 pubmed
    ..These results identify a prominent role for selectin ligands in contributing to effector CD8+ T cell recruitment into the myocardium and indicate that selectin-dependent T cell recruitment is relevant to other tissues besides the skin. ..
  2. Smithson G, Rogers C, Smith P, Scheidegger E, Petryniak B, Myers J, et al. Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes. J Exp Med. 2001;194:601-14 pubmed
  3. Dudda J, Perdue N, Bachtanian E, Campbell D. Foxp3+ regulatory T cells maintain immune homeostasis in the skin. J Exp Med. 2008;205:1559-65 pubmed publisher
    ..with cells whose ability to migrate to the skin was impaired because of targeted mutation of alpha-1,3-fucosyltransferase VII (Fut7)...
  4. Hiraoka N, Petryniak B, Kawashima H, Mitoma J, Akama T, Fukuda M, et al. Significant decrease in alpha1,3-linked fucose in association with increase in 6-sulfated N-acetylglucosamine in peripheral lymph node addressin of FucT-VII-deficient mice exhibiting diminished lymphocyte homing. Glycobiology. 2007;17:277-93 pubmed
    ..These results combined together suggest that KSST competes with FucT-VII for the same acceptor substrate and downregulates the synthesis of L-selectin ligand by inhibiting alpha1,3-fucosylation. ..
  5. Arata Kawai H, Singer M, Bistrup A, Zante A, Wang Y, Ito Y, et al. Functional contributions of N- and O-glycans to L-selectin ligands in murine and human lymphoid organs. Am J Pathol. 2011;178:423-33 pubmed publisher
    ..These findings extend the evidence for the importance of N-glycans in lymphocyte homing in mouse and indicate that this dependency also applies to human lymphoid organs. ..
  6. Schroeter M, Ratsch B, Lehmann J, Baumgrass R, Hamann A, Syrbe U. Differential regulation and impact of fucosyltransferase VII and core 2 ?1,6-N-acetyl-glycosaminyltransferase for generation of E-selectin and P-selectin ligands in murine CD4+ T cells. Immunology. 2012;137:294-304 pubmed publisher
    ..Glycosyltransferases, especially ? 1,3-fucosyltransferase VII (FucT-VII) and core 2 ?1,6-N-acetyl-glycosaminyltransferase I (C2GlcNAcT-I), are critical for their ..
  7. Zhang S, Condac E, Qiu H, Jiang J, Gutierrez Sanchez G, Bergmann C, et al. Heparin-induced leukocytosis requires 6-O-sulfation and is caused by blockade of selectin- and CXCL12 protein-mediated leukocyte trafficking in mice. J Biol Chem. 2012;287:5542-53 pubmed publisher
    ..We conclude that heparin-induced leukocytosis requires glucosamine 6-O-sulfation and is caused by blockade of L-selectin-, P-selectin-, and CXCL12-mediated leukocyte trafficking...
  8. Burne M, Rabb H. Pathophysiological contributions of fucosyltransferases in renal ischemia reperfusion injury. J Immunol. 2002;169:2648-52 pubmed
    ..These data demonstrate that fucosyltransferases are important in the pathogenesis of renal IRI and are potential therapeutic targets. ..
  9. Stark M, Huo Y, Burcin T, Morris M, Olson T, Ley K. Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity. 2005;22:285-94 pubmed
    ..Antibody blockade of the p40 subunit of IL-23 reduces neutrophil numbers in wild-type mice. These findings identify a major homeostatic mechanism for the regulation of neutrophil production in vivo. ..
  10. Smith P, Gersten K, Petryniak B, Kelly R, Rogers C, Natsuka Y, et al. Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid aggregate high endothelial venules correlates with expression of L-selectin ligands. J Biol Chem. 1996;271:8250-9 pubmed
    ..These observations suggest that Fuc-TVII participates in the generation of alpha(1,3)fucosylated ligands for L-selectin and provide further evidence for a role for this enzyme in E- and P-selectin ligand expression in leukocytes. ..
  11. Beck P, Xavier R, Lu N, Nanda N, Dinauer M, Podolsky D, et al. Mechanisms of NSAID-induced gastrointestinal injury defined using mutant mice. Gastroenterology. 2000;119:699-705 pubmed
    ..was assessed by neutrophil depletion, impairment of recruitment (resulting from targeted disruption of fucosyltransferase VII [FTVII]), and the absence of mature T and B cells with the use of Rag 2(-/-) mice...
  12. Suzukawa M, Miller M, Rosenthal P, Cho J, Doherty T, Varki A, et al. Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice. J Immunol. 2013;190:5939-48 pubmed publisher
    ..Overall, these studies demonstrate that ST3Gal-III plays an important role in Siglec-F ligand formation and eosinophil apoptosis with resultant effects on eosinophilic inflammation in the lung. ..
  13. Beck P, Ihara E, Hirota S, MacDonald J, Meng D, Nanthakumar N, et al. Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3. Am J Physiol Gastrointest Liver Physiol. 2010;299:G43-53 pubmed publisher
    Intestinal mucosal integrity is dependent on epithelial function and a regulated immune response to injury. Fucosyltransferase VII (Fuc-TVII) is an essential enzyme required for the expression of the functional ligand for E- and P-..
  14. Hauselmann I, Roblek M, Protsyuk D, Huck V, Knopfova L, Grässle S, et al. Monocyte Induction of E-Selectin-Mediated Endothelial Activation Releases VE-Cadherin Junctions to Promote Tumor Cell Extravasation in the Metastasis Cascade. Cancer Res. 2016;76:5302-12 pubmed publisher
    ..These findings provide evidence that endothelial E-selectin is a novel factor contributing to endothelial retraction required for efficient lung metastasis. Cancer Res; 76(18); 5302-12. ©2016 AACR. ..
  15. Gainers M, Descheny L, Barthel S, Liu L, Wurbel M, Dimitroff C. Skin-homing receptors on effector leukocytes are differentially sensitive to glyco-metabolic antagonism in allergic contact dermatitis. J Immunol. 2007;179:8509-18 pubmed
  16. Pink M, Ratsch B, Mardahl M, Durek P, Polansky J, Karl M, et al. Imprinting of Skin/Inflammation Homing in CD4+ T Cells Is Controlled by DNA Methylation within the Fucosyltransferase 7 Gene. J Immunol. 2016;197:3406-3414 pubmed
    ..In this study, we examined the transcriptional regulation of fucosyltransferase 7 (FUT7), an enzyme crucial for generation of the glycosylated E- and P-ligs...
  17. Sultana D, Zhang S, Todd S, Bhandoola A. Expression of functional P-selectin glycoprotein ligand 1 on hematopoietic progenitors is developmentally regulated. J Immunol. 2012;188:4385-93 pubmed publisher
    ..These studies provide insight into the developmentally regulated expression of a critical determinant involved in progenitor homing to the thymus. ..
  18. Liu Z, Yago T, Zhang N, Panicker S, Wang Y, Yao L, et al. L-selectin mechanochemistry restricts neutrophil priming in vivo. Nat Commun. 2017;8:15196 pubmed publisher
    ..Thus, L-selectin mechanochemistry limits premature activation of neutrophils. Our results highlight the importance of probing how mechanochemistry functions in vivo. ..
  19. Saeki K, Satoh T, Yokozeki H. ?(1,3) Fucosyltransferases IV and VII are essential for the initial recruitment of basophils in chronic allergic inflammation. J Invest Dermatol. 2013;133:2161-9 pubmed publisher
    ..Functional PSGL-1 generated by basophil FT-IV/VII and its subsequent binding to L-selectin could be one of the essential steps required for initial basophil recruitment and the development of IgE-CAI in mice. ..
  20. Fabene P, Navarro Mora G, Martinello M, Rossi B, Merigo F, Ottoboni L, et al. A role for leukocyte-endothelial adhesion mechanisms in epilepsy. Nat Med. 2008;14:1377-83 pubmed publisher
    ..Our results suggest leukocyte-endothelial interaction as a potential target for the prevention and treatment of epilepsy. ..
  21. Lacha J, Bushell A, Smetana K, Rossmann P, Pribylová P, Wood K, et al. Intercellular cell adhesion molecule-1 and selectin ligands in acute cardiac allograft rejection: a study on gene-deficient mouse models. J Leukoc Biol. 2002;71:311-8 pubmed
  22. Jones C, Denecke J, Sträter R, Stölting T, Schunicht Y, Zeuschner D, et al. A novel type of macrothrombocytopenia associated with a defect in ?2,3-sialylation. Am J Pathol. 2011;179:1969-77 pubmed publisher
    ..Taken together, this is the first type of human thrombocytopenia in which a specific defect of ?2,3-sialylation and an induction of platelet binding to the liver ASGP-R could be detected. ..
  23. Schreiber T, Ehlers S, Aly S, Hölscher A, Hartmann S, Lipp M, et al. Selectin ligand-independent priming and maintenance of T cell immunity during airborne tuberculosis. J Immunol. 2006;176:1131-40 pubmed
  24. Wang H, Morales Levy M, Rose J, Mackey L, Bodary P, EITZMAN D, et al. ?(1,3)-Fucosyltransferases FUT4 and FUT7 control murine susceptibility to thrombosis. Am J Pathol. 2013;182:2082-93 pubmed publisher
    The ?(1,3)-fucosyltransferases, types IV and VII (FUT4 and FUT7, respectively), are required for the synthesis of functional selectin-type leukocyte adhesion molecule ligands...
  25. Gitlin J, Homeister J, Bulgrien J, Counselman J, Curtiss L, Lowe J, et al. Disruption of tissue-specific fucosyltransferase VII, an enzyme necessary for selectin ligand synthesis, suppresses atherosclerosis in mice. Am J Pathol. 2009;174:343-50 pubmed publisher
    ..In this study, we have determined the role of tissue-specific fucosyltransferase VII (FucT-VII), an enzyme necessary for selectin ligand synthesis, in the development of atherosclerosis...
  26. Jiang X, Clark R, Liu L, Wagers A, Fuhlbrigge R, Kupper T. Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature. 2012;483:227-31 pubmed publisher
    ..These findings have important implications for our understanding of protective immune memory at epithelial interfaces with the environment, and suggest novel strategies for vaccines that protect against tissue tropic organisms. ..
  27. Zhang N, Schroppel B, Lal G, Jakubzick C, Mao X, Chen D, et al. Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity. 2009;30:458-69 pubmed publisher
    ..These results showed that sequential migration from blood to the target tissue and to dLNs is required for Treg cells to differentiate and execute fully their suppressive function. ..
  28. Satoh T, Kanai Y, Wu M, Yokozeki H, Kannagi R, Lowe J, et al. Synthesis of {alpha}(1,3) fucosyltransferases IV- and VII-dependent eosinophil selectin ligand and recruitment to the skin. Am J Pathol. 2005;167:787-96 pubmed
  29. Ebel M, Kansas G. Defining the functional boundaries of the murine ?1,3-fucosyltransferase Fut7 reveals a remarkably compact locus. J Biol Chem. 2014;289:6341-9 pubmed publisher
    b>Fut7 encodes an ?1,3-fucosyltransferase critical for biosynthesis of glycan ligands for all three selectins...
  30. Pink M, Ratsch B, Mardahl M, Schröter M, Engelbert D, Triebus J, et al. Identification of two regulatory elements controlling Fucosyltransferase 7 transcription in murine CD4+ T cells. Mol Immunol. 2014;62:1-9 pubmed publisher
    b>Fucosyltransferase VII encoded by the gene Fut7 is essential in CD4(+) T cells for the generation of E- and P-selectin ligands (E- and P-lig) which facilitate recruitment of lymphocytes into inflamed tissues and into the skin...
  31. Ledgerwood L, Lal G, Zhang N, Garin A, Esses S, Ginhoux F, et al. The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics. Nat Immunol. 2008;9:42-53 pubmed
    ..Thus, the increased sphingosine 1-phosphate present in inflamed peripheral tissues may induce T cell retention and suppress T cell egress. ..
  32. Piccio L, Rossi B, Colantonio L, Grenningloh R, Gho A, Ottoboni L, et al. Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII. J Immunol. 2005;174:5805-13 pubmed
    ..These observations allow us to conclude that efficient recruitment of activated lymphocytes to the brain in the contexts mimicking EAE is controlled by FucT-VII and its cognate cell surface Ag CLA. ..
  33. Sarraj B, Ye J, Akl A, Chen G, Wang J, Zhang Z, et al. Impaired selectin-dependent leukocyte recruitment induces T-cell exhaustion and prevents chronic allograft vasculopathy and rejection. Proc Natl Acad Sci U S A. 2014;111:12145-50 pubmed publisher
    ..Fucosyltransferase-VII (FucT-VII), encoded by Fut7, is essential for biosynthesis of selectin ligands...
  34. Homeister J, Daugherty A, Lowe J. Alpha(1,3)fucosyltransferases FucT-IV and FucT-VII control susceptibility to atherosclerosis in apolipoprotein E-/- mice. Arterioscler Thromb Vasc Biol. 2004;24:1897-903 pubmed
    ..These studies identify an important role for FucT-VII in atherogenesis, and a subsidiary role for FucT-IV, and implicate leukocyte selectin counter-receptors in the pathogenesis of atherosclerosis. ..
  35. Doebis C, Siegmund K, Loddenkemper C, Lowe J, Issekutz A, Hamann A, et al. Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction. Am J Pathol. 2008;173:1067-76 pubmed publisher
    ..However, only the presence of selectin ligands on T cells was critical for the inflammatory reaction. These findings reveal T cells as the predominant targets for selectin blockade that aim to suppress skin inflammation. ..
  36. Hirose M, Matsumura R, Sato K, Murai T, Kawashima H. Binding of L-selectin to its vascular and extravascular ligands is differentially regulated by pH. Biochem Biophys Res Commun. 2011;414:437-42 pubmed publisher
    ..8 to 7.4, and no rolling was detected at pH conditions below 5.6. These findings suggest that the pH environment is one important factor that determines leukocyte trafficking under physiological and pathological conditions. ..
  37. Kumar A, Torii T, Ishino Y, Muraoka D, Yoshimura T, Togayachi A, et al. The Lewis X-related ?1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations. J Biol Chem. 2013;288:28859-68 pubmed publisher
    ..Our data suggest that Fut10 is involved in a unique ?1,3-fucosyltransferase activity with stringent substrate specificity, and that this activity is required to maintain stem cells in an undifferentiated state. ..
  38. Hoos A, Protsyuk D, Borsig L. Metastatic growth progression caused by PSGL-1-mediated recruitment of monocytes to metastatic sites. Cancer Res. 2014;74:695-704 pubmed publisher
    ..Thus, the recruitment of monocytes to metastasizing tumor cells is facilitated by endogenous selectin ligands on monocytes that enable efficient tumor cell survival, extravasation, and metastasis. ..
  39. Carlyon J, Akkoyunlu M, Xia L, Yago T, Wang T, Cummings R, et al. Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum. Blood. 2003;102:3387-95 pubmed
    ..However, murine infection does not require neutrophil PSGL-1 expression, which has important implications for understanding how A phagocytophilum binds and infects neutrophils. ..
  40. Stark F, Gurnani K, Sad S, Krishnan L. Lack of functional selectin ligand interactions compromises long term tumor protection by CD8+ T cells. PLoS ONE. 2012;7:e32211 pubmed publisher
    ..These results reveal that selectin ligand expression on host endothelium as well CD8(+) T cells may be important for their efficient and continued extravasation into peripheral tumors. ..
  41. Zhou L, Li L, Yan Q, Petryniak B, Man Y, Su C, et al. Notch-dependent control of myelopoiesis is regulated by fucosylation. Blood. 2008;112:308-19 pubmed publisher
  42. Hoefer I, van Royen N, Rectenwald J, Deindl E, Hua J, Jost M, et al. Arteriogenesis proceeds via ICAM-1/Mac-1- mediated mechanisms. Circ Res. 2004;94:1179-85 pubmed
  43. Laubli H, Stevenson J, Varki A, Varki N, Borsig L. L-selectin facilitation of metastasis involves temporal induction of Fut7-dependent ligands at sites of tumor cell arrest. Cancer Res. 2006;66:1536-42 pubmed
    ..These data provide the first explanation for how leukocyte L-selectin facilitates tumor metastasis. ..
  44. Nacher M, Blazquez A, Shao B, Matesanz A, Prophete C, Berin M, et al. Physiological contribution of CD44 as a ligand for E-Selectin during inflammatory T-cell recruitment. Am J Pathol. 2011;178:2437-46 pubmed publisher
    ..Our results identify additional mechanisms by which CD44 modulates the inflammatory response. ..
  45. Chen S, Kawashima H, Lowe J, Lanier L, Fukuda M. Suppression of tumor formation in lymph nodes by L-selectin-mediated natural killer cell recruitment. J Exp Med. 2005;202:1679-89 pubmed
    ..These findings indicate that L-selectin-mediated NK cell recruitment plays a crucial role in the control of tumor metastasis into secondary lymphoid organs. ..
  46. Hirakawa J, Tsuboi K, Sato K, Kobayashi M, Watanabe S, Takakura A, et al. Novel anti-carbohydrate antibodies reveal the cooperative function of sulfated N- and O-glycans in lymphocyte homing. J Biol Chem. 2010;285:40864-78 pubmed publisher
    ..Thus, the two mAbs generated by a novel method revealed the cooperative function of sulfated N- and O-glycans in lymphocyte homing and immune surveillance. ..
  47. Eom H, Rubio M, Means T, Luster A, Sykes M. T-cell P/E-selectin ligand alpha(1,3)fucosylation is not required for graft-vs-host disease induction. Exp Hematol. 2005;33:1564-73 pubmed
    ..These results suggest that donor T cells, including Th1, are capable of trafficking to GVHD target tissues independently of P- and E- selectin ligand in conditioned hosts. ..