Fut2

Summary

Gene Symbol: Fut2
Description: fucosyltransferase 2
Alias: GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2, alpha(1,2)FT 2, galactoside 2-alpha-L-fucosyltransferase 2, secretory blood group protein 2
Species: mouse

Top Publications

  1. pmc Identification of the plasticity-relevant fucose-alpha(1-2)-galactose proteome from the mouse olfactory bulb
    Heather E Murrey
    Howard Hughes Medical Institute and Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Biochemistry 48:7261-70. 2009
  2. doi Macrophage-derived LIF and IL1B regulate alpha(1,2)fucosyltransferase 2 (Fut2) expression in mouse uterine epithelial cells during early pregnancy
    Melinda J Jasper
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 84:179-88. 2011
  3. ncbi Genetic manipulation of blood group carbohydrates alters development and pathfinding of primary sensory axons of the olfactory systems
    James A St John
    Brain Growth and Regeneration Laboratory, School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Queensland, Australia
    Dev Biol 298:470-84. 2006
  4. ncbi Comparison of the three rat GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferases FTA, FTB and FTC
    V Bureau
    INSERM U419, Institut de Biologie, Nantes, France
    Eur J Biochem 268:1006-19. 2001
  5. ncbi Molecular cloning, genomic mapping, and expression of two secretor blood group alpha (1,2)fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract
    S E Domino
    Department of Obstetrics and Gynecology, Howard Hughes Medical Institute, The University of Michigan Medical School, Ann Arbor, Michigan 48109 0650, USA
    J Biol Chem 276:23748-56. 2001
  6. pmc Tissue-specific loss of fucosylated glycolipids in mice with targeted deletion of alpha(1,2)fucosyltransferase genes
    Masao Iwamori
    Department of Biochemistry, Faculty of Science and Technology, Kinki University, 3 4 1 Kowakae, Higashiosaka, Osaka 577 8502, Japan
    Biochem J 380:75-81. 2004
  7. pmc Deficiency of reproductive tract alpha(1,2)fucosylated glycans and normal fertility in mice with targeted deletions of the FUT1 or FUT2 alpha(1,2)fucosyltransferase locus
    S E Domino
    Department of Obstetrics and Gynecology, 6428 Medical Science Bldg 1, The University of Michigan Medical School, 1150 West Medical Center Dr, Ann Arbor, MI 48109, USA
    Mol Cell Biol 21:8336-45. 2001
  8. pmc Widespread gene conversion of alpha-2-fucosyltransferase genes in mammals
    Joana Abrantes
    CIBIO UP, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Vairao, Portugal
    J Mol Evol 69:22-31. 2009
  9. doi Ectopic expression of blood type antigens in inflamed mucosa with higher incidence of FUT2 secretor status in colonic Crohn's disease
    Jun Miyoshi
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Gastroenterol 46:1056-63. 2011
  10. doi A novel role for inducible Fut2 in angiogenesis
    Pei Suen Tsou
    Department of Medicine, University of Michigan Medical School, Ann Arbor, 48109, USA
    Angiogenesis 16:195-205. 2013

Research Grants

Scientific Experts

  • Masao Iwamori
  • Bei Lin
  • Steven E Domino
  • Melinda J Jasper
  • Pei Suen Tsou
  • Jun Miyoshi
  • Chunmei Wang
  • Kazutaka Terahara
  • Jacques Le Pendu
  • Joana Abrantes
  • Heather E Murrey
  • Ana Magalhaes
  • James A St John
  • Elizabeth A Hurd
  • Alisa E Koch
  • Mohammad A Amin
  • Jeffrey H Ruth
  • Hubert Marotte
  • Takeo Isozaki
  • Phillip L Campbell
  • Solhee Lee
  • V Bureau
  • Chengyang Huang
  • Yoshikazu Yuki
  • Makio Mukai
  • Yihua Gu
  • Takachika Hiroi
  • Atsushi Nakazawa
  • Shiho Kurokawa
  • Katsuyoshi Shimamura
  • Haruhiko Ogata
  • Masato Yoshida
  • Mi Na Kweon
  • Myoung Ho Jang
  • Tadakazu Hisamatsu
  • Yoshiyuki Goto
  • Hiroshi Kiyono
  • Yuko Takahashi
  • Tomoharu Yajima
  • Toshifumi Hibi
  • Yonglian Zhang
  • Yuchuan Zhou
  • Takanori Kanai
  • Yasuko Tsunetsugu-Yokota
  • Susumu Okamoto
  • Katsuyoshi Matsuoka
  • Yasushi Iwao
  • Tomonori Nochi
  • Nagamu Inoue
  • Kazuo Kobayashi
  • Hirotsugu Hatai
  • Zhengmei Zhu
  • Rainer Haas
  • Joana Gomes
  • Leonor David
  • Linda C Hsieh-Wilson
  • David Posada
  • Nuno Mendes
  • Anne Dell
  • Pedro J Esteves
  • Scott B Ficarro
  • Hugo Osorio
  • Eric C Peters
  • Patrice Guillon
  • Chithra Krishnamurthy
  • Celso A Reis
  • Thomas Boren
  • Mohd Nazri Ismail
  • Stuart M Haslam
  • Fumiichiro Yamamoto
  • Mark W Robinson
  • Christina Claxton
  • Brian Key
  • B Le Moullac-Vaidye
  • T Liehr
  • S Marionneau
  • A Cailleau-Thomas
  • J Le Pendu

Detail Information

Publications20

  1. pmc Identification of the plasticity-relevant fucose-alpha(1-2)-galactose proteome from the mouse olfactory bulb
    Heather E Murrey
    Howard Hughes Medical Institute and Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    Biochemistry 48:7261-70. 2009
    ..Our findings significantly expand the number of Fucalpha(1-2)Gal glycoproteins and provide new insights into the molecular mechanisms by which fucosyl sugars contribute to neuronal processes...
  2. doi Macrophage-derived LIF and IL1B regulate alpha(1,2)fucosyltransferase 2 (Fut2) expression in mouse uterine epithelial cells during early pregnancy
    Melinda J Jasper
    Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 84:179-88. 2011
    ..of fucosylated structures required for embryo attachment and implantation, fucosyltransferase enzymes Fut1, Fut2 (Enzyme Commission number [EC] 2.4.1.69), and Fut4 (EC 2.4.1...
  3. ncbi Genetic manipulation of blood group carbohydrates alters development and pathfinding of primary sensory axons of the olfactory systems
    James A St John
    Brain Growth and Regeneration Laboratory, School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Queensland, Australia
    Dev Biol 298:470-84. 2006
    ..These results provide in vivo evidence for a role of specific cell surface carbohydrates during development of the olfactory nerve pathways...
  4. ncbi Comparison of the three rat GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferases FTA, FTB and FTC
    V Bureau
    INSERM U419, Institut de Biologie, Nantes, France
    Eur J Biochem 268:1006-19. 2001
    ..Sequence analysis revealed that these genes, called FTA, FTB and FTC, were homologous to human FUT1, FUT2 and Sec1, respectively...
  5. ncbi Molecular cloning, genomic mapping, and expression of two secretor blood group alpha (1,2)fucosyltransferase genes differentially regulated in mouse uterine epithelium and gastrointestinal tract
    S E Domino
    Department of Obstetrics and Gynecology, Howard Hughes Medical Institute, The University of Michigan Medical School, Ann Arbor, Michigan 48109 0650, USA
    J Biol Chem 276:23748-56. 2001
    ..DNA probes from the open reading frames of the mouse fucosyltransferase genes corresponding to human FUT1, FUT2, and SEC1 demonstrate distinct tissue-specific expression patterns by Northern blot analyses...
  6. pmc Tissue-specific loss of fucosylated glycolipids in mice with targeted deletion of alpha(1,2)fucosyltransferase genes
    Masao Iwamori
    Department of Biochemistry, Faculty of Science and Technology, Kinki University, 3 4 1 Kowakae, Higashiosaka, Osaka 577 8502, Japan
    Biochem J 380:75-81. 2004
    ..products were measured in tissues of wild-type and mutant mice lacking alpha(1,2)fucosyltransferase genes FUT1 or FUT2. Quantitative determination was performed by TLC-immunostaining for GA1 (Gg4Cer), FGA1 (fucosyl GA1), GM1 (II3NeuAc-..
  7. pmc Deficiency of reproductive tract alpha(1,2)fucosylated glycans and normal fertility in mice with targeted deletions of the FUT1 or FUT2 alpha(1,2)fucosyltransferase locus
    S E Domino
    Department of Obstetrics and Gynecology, 6428 Medical Science Bldg 1, The University of Michigan Medical School, 1150 West Medical Center Dr, Ann Arbor, MI 48109, USA
    Mol Cell Biol 21:8336-45. 2001
    ..are required for fertility, we have generated strains of mice that are deficient in genes encoding FUT1 and FUT2, a pair of GDP-L-fucose:beta(1-->4)-D-galactosyl-R 2-alpha-L-fucosyltransferase enzymes (EC 2.4.1...
  8. pmc Widespread gene conversion of alpha-2-fucosyltransferase genes in mammals
    Joana Abrantes
    CIBIO UP, Centro de Investigacao em Biodiversidade e Recursos Geneticos, Vairao, Portugal
    J Mol Evol 69:22-31. 2009
    ..In mammalian genomes, there are three alpha2FT genes located in tandem-FUT1, FUT2, and Sec1-each contained within a single exon...
  9. doi Ectopic expression of blood type antigens in inflamed mucosa with higher incidence of FUT2 secretor status in colonic Crohn's disease
    Jun Miyoshi
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Gastroenterol 46:1056-63. 2011
    ..Some known receptors are the mucosal blood type antigens, which are regulated by the fucosyltransferase2 (FUT2) gene, and individuals who express these antigens in the gastrointestinal tract are called secretors...
  10. doi A novel role for inducible Fut2 in angiogenesis
    Pei Suen Tsou
    Department of Medicine, University of Michigan Medical School, Ann Arbor, 48109, USA
    Angiogenesis 16:195-205. 2013
    ..Angiogenesis plays an important role in wound healing and tumor growth. Fucosyltransferases synthesize fucosylated glycans and may play a major role in vascular biology...
  11. ncbi [Cloning and expression of murine alpha1,2-fucosyltransferase gene]
    Bei Lin
    Department of Obstetrics and Gynecology, The Second Affiliated Hospital of China Medical University, Shenyang 110004
    Shi Yan Sheng Wu Xue Bao 38:536-44. 2005
    ..COS-7 cells transfected with pcDNA3.1-MFUT- II showed alpha 1,2-fucosyltransferase activity. Southern analysis revealed that MFUT-II was present in the mouse genome as a single-copy gene. In conclusion, MFUT-II was a murine Se gene...
  12. ncbi GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase, MFUT-II, and not MFUT-I or -III, is induced in a restricted region of the digestive tract of germ-free mice by host-microbe interactions and cycloheximide
    B Lin
    Department of Biochemistry and Molecular Biology, University of Tokyo, Hongo, Tokyo, Japan
    Biochim Biophys Acta 1487:275-85. 2000
    ..At 24 h after the administration of cycloheximide, FGA1 was preferentially produced in the upper half of the duodenal microvilli...
  13. doi Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress
    Kazutaka Terahara
    Department of Immunology, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Biochem Biophys Res Commun 404:822-8. 2011
    ..fucosylation of Peyer's patch M cells and F-ECs was distinctly regulated by α(1,2)fucosyltransferase Fut1 and Fut2, respectively...
  14. doi Biosynthesis and distribution of Lewis X- and Lewis Y-containing glycoproteins in the murine male reproductive system
    Chunmei Wang
    Shanghai Key Laboratory of Molecular Andrology, State Key Laboratory of Molecular Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Glycobiology 21:225-34. 2011
    ..Lewis Y (LeY) antigens were thought to play important roles in fertility, fucosyltransferase (Fut)-deficient (Fut1, Fut2 and Fut4) mice which lack LeX or LeY antigen are still fertile...
  15. ncbi Characterization of three members of murine alpha1,2-fucosyltransferases: change in the expression of the Se gene in the intestine of mice after administration of microbes
    B Lin
    Department of Biochemistry and Molecular Biology, Graduate School of Medicine, University of Tokyo, Japan
    Arch Biochem Biophys 388:207-15. 2001
    ..The administration of microbes into germ-free mice resulted in a rapid increase of the MFUT-II gene (Se gene) for the synthesis of fucosyl GA1 in the intestine...
  16. pmc Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa
    Ana Magalhaes
    Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
    Glycobiology 19:1525-36. 2009
    Glycoconjugates expressed on gastric mucosa play a crucial role in host-pathogen interactions. The FUT2 enzyme catalyzes the addition of terminal alpha(1,2)fucose residues, producing the H type 1 structure expressed on the surface of ..
  17. pmc LacZ expression in Fut2-LacZ reporter mice reveals estrogen-regulated endocervical glandular expression during estrous cycle, hormone replacement, and pregnancy
    Steven E Domino
    Department of Obstetrics and Gynecology, Cellular and Molecular Biology Program, 6428 Medical Science I Box 0617, University of Michigan Medical Center, Ann Arbor, MI 48109 0617, USA
    Glycobiology 14:169-75. 2004
    The secretor gene (FUT2) encodes an alpha(1,2)fucosyltransferase (E.C. 2.4.1.69) that elaborates alpha(1,2)fucose residues on mucosal epithelium and secreted mucins...
  18. pmc Increased susceptibility of secretor factor gene Fut2-null mice to experimental vaginal candidiasis
    Elizabeth A Hurd
    Department of Obstetrics and Gynecology, 6428 Medical Science I, Box 0617, University of Michigan, Ann Arbor, MI 48109 0617, USA
    Infect Immun 72:4279-81. 2004
    b>Fut2-LacZ-null mice, which are a model of the human ABO and Lewis nonsecretor group, display increased susceptibility to experimental yeast vaginitis, indicating a role for alpha(1,2)fucosylated cervical glycans in mucosal defense...
  19. pmc Cell surface fucosylation does not affect development of colon tumors in mice with germline Smad3 mutation
    Steven E Domino
    Department of Obstetrics and Gynecology, Cellular and Molecular Biology Program, University of Michigan Medical Center, Ann Arbor, Mich, USA
    Tumour Biol 28:77-83. 2007
    ..Spontaneous colorectal tumors from mice with a germline null mutation of transforming growth factor-beta signaling gene Smad3 (Madh3) were tested for alpha(1,2)fucosylated glycan expression...
  20. pmc Molecular cloning, chromosomal assignment and tissue-specific expression of a murine alpha(1,2)fucosyltransferase expressed in thymic and epididymal epithelial cells
    S E Domino
    Department of Obstetrics and Gynecology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 0650, USA
    Biochem J 327:105-15. 1997
    ..encoded by human FUT1, and 55% sequence identity with the enzyme encoded by the human Secretor blood group locus (FUT2)...

Research Grants1

  1. Fucosylated cell surface molecules in tumor invasion
    STEVEN DOMINO; Fiscal Year: 2005
    ..The approach I have chosen is to ablate in mice the transferase enzymes Fut1 and Fut2 required to generate alpha(1,2)fucosylated oligosaccharides...