Frzb

Summary

Gene Symbol: Frzb
Description: frizzled-related protein
Alias: Frp, Sfrp3, frezzled, fritz, frzb-1, frizzled-related protein 1, sFRP-3, secreted frizzled-related protein 3, secreted frizzled-related sequence protein 3
Species: mouse

Top Publications

  1. pmc Epithelial Wnt/β-catenin signaling regulates palatal shelf fusion through regulation of Tgfβ3 expression
    Fenglei He
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Dev Biol 350:511-9. 2011
  2. pmc Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis
    Mi Hyeon Jang
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Stem Cell 12:215-23. 2013
  3. ncbi Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice
    Rik J U Lories
    Laboratory for Skeletal Development and Joint Disorders, Department of Rheumatology, University Hospitals Leuven, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
    Arthritis Rheum 56:4095-103. 2007
  4. ncbi Effects of secreted frizzled-related protein 3 on osteoblasts in vitro
    Yoon Sok Chung
    Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, South Korea
    J Bone Miner Res 19:1395-402. 2004
  5. pmc Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium
    Ben Van Handel
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 150:590-605. 2012
  6. pmc Wnt inhibitory factor 1 (Wif1) is regulated by androgens and enhances androgen-dependent prostate development
    Kimberly P Keil
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    Endocrinology 153:6091-103. 2012
  7. doi Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone
    Cesca van de Ven
    Hubrecht Institute, Developmental Biology and Stem Cell Research, Utrecht, The Netherlands
    Development 138:3451-62. 2011
  8. doi Restriction of Wnt signaling in the dorsal otocyst determines semicircular canal formation in the mouse embryo
    Teppei Noda
    Department of Developmental Biology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Dev Biol 362:83-93. 2012
  9. ncbi Expression pattern of two Frizzled-related genes, Frzb-1 and Sfrp-1, during mouse embryogenesis suggests a role for modulating action of Wnt family members
    B H Hoang
    Department of Orthopaedics, University Hospitals of Cleveland, Case Western Reserve University, Ohio 44106, USA
    Dev Dyn 212:364-72. 1998
  10. doi SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells
    Julianna Kele
    Laboratory of Molecular Neurobiology, Medical Biochemistry and Biophysics, Karolinska Institute, Scheeleväg 1, Stockholm, Sweden
    Stem Cells 30:865-75. 2012

Scientific Experts

  • Rik Ju Lories
  • R K Ladher
  • A Wodarz
  • B C Jones
  • Przemko Tylzanowski
  • Christine E Dawe
  • Mi Hyeon Jang
  • Frank P Luyten
  • Kimberly P Keil
  • Julianna Kele
  • Liesbet Lodewyckx
  • Anita John
  • Ben Van Handel
  • Teppei Noda
  • Cesca van de Ven
  • Fenglei He
  • Christina M Alfieri
  • Sun Wook Cho
  • Makoto M Taketo
  • Wei Liu
  • Danuta Wawrzak
  • Dong Qian
  • Heiko Lickert
  • Siming Shou
  • Robert G Kelly
  • Sandra D Dreyer
  • Yoon Sok Chung
  • Tomomi Shimogori
  • Hong Liu
  • Mahua Mukhopadhyay
  • Christina N Bennett
  • Eunchai Kang
  • Juan Song
  • Yijing Su
  • L Leyns
  • Chun Zhong
  • Yuan Gao
  • Ju Young Kim
  • Guo li Ming
  • Junjie U Guo
  • Yasuji Kitabatake
  • Jiaqi Sun
  • Heechul Jun
  • Michael A Bonaguidi
  • Marie Xun Wang
  • Kimberly M Christian
  • Hongjun Song
  • Kurt A Sailor
  • Jau Nian Chen
  • Sean Hunter
  • Tõnis Org
  • Hanna K A Mikkola
  • Neal G Copeland
  • Lukas Cajanek
  • Matteo Pellegrini
  • Keiko Kitajima
  • Emma R Andersson
  • J W Yam
  • E Bryan Crenshaw
  • Enrique M Toledo
  • Vitezslav Bryja
  • Carmen Birchmeier
  • Siavash K Kurdistani
  • Stuart H Orkin
  • Ernest Arenas
  • Shizuo Komune
  • Rajkumar Sasidharan
  • Clare L Parish
  • Sonia Bonilla
  • Chad M Vezina
  • Roberto Ferrari
  • Atsushi Nakano
  • Frederic Cailotto
  • Pentao Liu
  • Yanling Wang
  • Rita A Buresh-Stiemke
  • Christoph Wiegreffe
  • Amanda M Branam
  • Stefan Britsch
  • Christopher T Schmitz
  • Sarah Thysen
  • Tetsuro Harada
  • Jeffrey S Rubin
  • René Jüttner
  • Chikara Meno
  • Shinya Oki
  • Sylvia M Evans
  • M Tebar
  • Nancy A Jenkins
  • Haruko Nakano

Detail Information

Publications41

  1. pmc Epithelial Wnt/β-catenin signaling regulates palatal shelf fusion through regulation of Tgfβ3 expression
    Fenglei He
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Dev Biol 350:511-9. 2011
    ..Collectively, our results demonstrate an essential role for Wnt/β-catenin signaling in the epithelial component at the step of palate fusion during palate development by controlling the expression of Tgfβ3 in the MEE...
  2. pmc Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis
    Mi Hyeon Jang
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell Stem Cell 12:215-23. 2013
    ..Here, we report that neuronal activity decreases the expression of secreted frizzled-related protein 3 (sFRP3), a naturally secreted Wnt inhibitor highly expressed by adult dentate gyrus granule neurons...
  3. ncbi Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice
    Rik J U Lories
    Laboratory for Skeletal Development and Joint Disorders, Department of Rheumatology, University Hospitals Leuven, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
    Arthritis Rheum 56:4095-103. 2007
    ..In particular, polymorphisms in the FRZB gene, a secreted WNT antagonist, have been associated with osteoarthritis...
  4. ncbi Effects of secreted frizzled-related protein 3 on osteoblasts in vitro
    Yoon Sok Chung
    Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, South Korea
    J Bone Miner Res 19:1395-402. 2004
    To examine if sFRP3s act as decoy receptors for Wnt, we examined the effects of recombinant sFRP3 on mouse osteoblast proliferation and differentiation...
  5. pmc Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium
    Ben Van Handel
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 150:590-605. 2012
    ..These results reveal unexpected plasticity in embryonic endothelium such that loss of a single master regulator can induce ectopic cardiomyogenesis from endothelial cells...
  6. pmc Wnt inhibitory factor 1 (Wif1) is regulated by androgens and enhances androgen-dependent prostate development
    Kimberly P Keil
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    Endocrinology 153:6091-103. 2012
    ....
  7. doi Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone
    Cesca van de Ven
    Hubrecht Institute, Developmental Biology and Stem Cell Research, Utrecht, The Netherlands
    Development 138:3451-62. 2011
    ..They shed a new light on the etiology of the caudal dysplasia or caudal regression range of human congenital defects...
  8. doi Restriction of Wnt signaling in the dorsal otocyst determines semicircular canal formation in the mouse embryo
    Teppei Noda
    Department of Developmental Biology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Dev Biol 362:83-93. 2012
    ..Our stage-specific functional analysis suggests that strict regulation of canonical Wnt signaling in the dorsal otocyst orchestrates the process of semicircular canal formation...
  9. ncbi Expression pattern of two Frizzled-related genes, Frzb-1 and Sfrp-1, during mouse embryogenesis suggests a role for modulating action of Wnt family members
    B H Hoang
    Department of Orthopaedics, University Hospitals of Cleveland, Case Western Reserve University, Ohio 44106, USA
    Dev Dyn 212:364-72. 1998
    ..We previously identified Frzb-1, a gene which encodes a secreted protein with homology in the ligand binding domain to the Wnt receptor Frizzled, ..
  10. doi SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells
    Julianna Kele
    Laboratory of Molecular Neurobiology, Medical Biochemistry and Biophysics, Karolinska Institute, Scheeleväg 1, Stockholm, Sweden
    Stem Cells 30:865-75. 2012
    ..Moreover, we suggest that low-medium concentrations of sFRPs may be used to enhance the DA differentiation of ESCs and improve their therapeutic application...
  11. doi Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development
    Anita John
    Institute of Molecular and Cellular Anatomy, Ulm University, 89081 Ulm, Germany
    Development 139:1831-41. 2012
    ..of Bcl11a mutants and identified dysregulated expression of the gene encoding secreted frizzled-related protein 3 (sFRP3, or Frzb)...
  12. pmc Tight regulation of wingless-type signaling in the articular cartilage - subchondral bone biomechanical unit: transcriptomics in Frzb-knockout mice
    Liesbet Lodewyckx
    Laboratory for Skeletal Development and Joint Disorders, Department of Development and Regeneration, KU Leuven, Belgium
    Arthritis Res Ther 14:R16. 2012
    The aim of this research was to study molecular changes in the articular cartilage and subchondral bone of the tibial plateau from mice deficient in frizzled-related protein (Frzb) compared to wild-type mice by transcriptome analysis.
  13. pmc Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer
    L Leyns
    Department of Biological Chemistry, University of California, Los Angeles 90095 1662, USA
    Cell 88:747-56. 1997
    b>Frzb-1 is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. Frzb-1 is widely expressed in adult mammalian tissues...
  14. ncbi Wnt3a binds to several sFRPs in the nanomolar range
    Danuta Wawrzak
    Laboratory for Cell Genetics, Vrije Universiteit Brussel VUB, Pleinlaan 2, B 1050 Brussels, Belgium
    Biochem Biophys Res Commun 357:1119-23. 2007
    ..Here we show, using surface plasmon resonance and purified proteins, that sFRP1, sFRP2, sFRP4, and Frzb bind directly to Wnt3a with affinities in the nanomolar range...
  15. pmc Wnt5a functions in planar cell polarity regulation in mice
    Dong Qian
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Dev Biol 306:121-33. 2007
    ..that Wnt5a forms a reciprocal expression pattern with a Wnt antagonist, the secreted frizzled-related protein 3 (Sfrp3 or Frzb), along the axis of planar polarization in the cochlear epithelium...
  16. ncbi Systems genetic analysis of peripheral iron parameters in the mouse
    Byron C Jones
    Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16827, USA
    Am J Physiol Regul Integr Comp Physiol 293:R116-24. 2007
    ..The results show that iron homeostasis is a complex trait and is influenced by multiple genes...
  17. doi Differential effects of secreted frizzled-related proteins (sFRPs) on osteoblastic differentiation of mouse mesenchymal cells and apoptosis of osteoblasts
    Sun Wook Cho
    Department of Internal Medicine, Seoul National University College of Medicine, 28 Yungun Dong, Chongno Gu, Seoul 110 744, Republic of Korea
    Biochem Biophys Res Commun 367:399-405. 2008
    ..In conclusion, we found that different repertoires of sFRPs exert differential effects on osteoblastic differentiation of mouse mesenchymal cells and cellular apoptosis of mouse osteoblasts in vitro...
  18. doi Coordinated molecular control of otic capsule differentiation: functional role of Wnt5a signaling and opposition by sfrp3 activity
    Wei Liu
    Department of Otorhinolaryngology Head and Neck Surgery, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Growth Factors 26:343-54. 2008
    ..We show that in the presence of secreted frizzled related protein 3 (sfrp3), a Wnt antagonist expressed in the developing inner ear, or Wnt5a-specific antisense ..
  19. doi Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development
    Christine E Dawe
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
    Dev Dyn 240:372-83. 2011
    ..The mechanism of Cecr2 action in neurogenesis and inner ear development is likely complex...
  20. ncbi Mechanisms of Wnt signaling in development
    A Wodarz
    Institut fur Genetik, Universitat Dusseldorf, Germany
    Annu Rev Cell Dev Biol 14:59-88. 1998
    ..Here we review recent data that have started to unravel the mechanisms of Wnt signaling...
  21. pmc Wnt signaling in heart valve development and osteogenic gene induction
    Christina M Alfieri
    Division of Molecular Cardiovascular Biology, Cincinnati Children s Medical Center, ML 7020, 240 Albert Sabin Way, Cincinnati, OH 45229, USA
    Dev Biol 338:127-35. 2010
    ..Together, these studies provide evidence for Wnt signaling as a regulator of endocardial cushion maturation as well as valve leaflet stratification, homeostasis, and pathogenesis...
  22. ncbi Transcriptome analysis of the murine forelimb and hindlimb autopod
    Siming Shou
    Research Division, Shriners Hospital for Children, Portland, OR 97239, USA
    Dev Dyn 234:74-89. 2005
    ..05) were detected between forelimb and hindlimb tissues including 38 new transcripts such as Rdh10, Frzb, Tbx18, and Hip that exhibit differential limb expression...
  23. ncbi Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos
    Heiko Lickert
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada
    Development 132:2599-609. 2005
    ..This functional genomic approach allows the rapid identification of functionally important components of embryonic development from large datasets of putative targets...
  24. ncbi Characterization of Frzb-Cre transgenic mouse
    Przemko Tylzanowski
    Department of Rheumatology, University of Leuven, Leuven, Belgium
    Genesis 40:200-4. 2004
    ..by secreted antagonists that either bind to the receptors directly (Dkk1) or to Wnt molecules themselves (Sfrp-FRZB family), preventing its subsequent binding to the receptor...
  25. ncbi Evaluation of mouse Sfrp3/Frzb1 as a candidate for the lst, Ul, and Far mutants on chromosome 2
    C L Peichel
    Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA
    Mamm Genome 9:385-7. 1998
  26. ncbi sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney
    B Lescher
    Max Planck Institut fur Immunbiologie, Abteilung für Molekulare Embryologie, Freiburg, Germany
    Dev Dyn 213:440-51. 1998
    ....
  27. ncbi Expression of Wnt signalling pathway genes during tooth development
    L Sarkar
    Department of Craniofacial Development, Guy s Tower, Guy s, Kings and St Thomas Schools of Medicine, Dentistry and Biomedical Sciences, Floor 28, Guy s Tower, London Bridge, London SE1 9RT, UK
    Mech Dev 85:197-200. 1999
    ..Wnt-5a and MFrzb1 show strong expression in the dental papilla mesenchyme...
  28. ncbi Transplacental delivery of the Wnt antagonist Frzb1 inhibits development of caudal paraxial mesoderm and skeletal myogenesis in mouse embryos
    U Borello
    Istituto Pasteur Cenci Bolognetti, Dipartimento di Istologia ed Embriologia Medica, Universita di Roma La Sapienza, Via A Scarpa 14, Italy
    Development 126:4247-55. 1999
    ..Taken together, these results suggest that Wnt signals may act by regulating both myogenic commitment and expansion of committed cells in the mouse mesoderm...
  29. ncbi SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm
    C S Lee
    Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Development 127:109-18. 2000
    ..Together, our results support the model that SHH-N at least in part employs SFRP2 to reduce WNT1/4 activity in the somitic mesoderm...
  30. ncbi Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick development
    R K Ladher
    Department of Craniofacial Development, Guy s, King s and St Thomas School of Dentistry, Guy s Tower, Floor 27, Guy s Hospital, London, SE1 9RT, United Kingdom
    Dev Biol 218:183-98. 2000
    ..In this paper we report the expression patterns of the chick homologues of Frzb, a known Wnt antagonist, and Sfrp-2...
  31. ncbi Wnt receptors and Wnt inhibitors are expressed in gradients in the developing telencephalon
    A S Kim
    Neurodevelopmental Disorders Laboratory, Department of Neurology, University of California, San Francisco, CA 94143 0435, USA
    Mech Dev 103:167-72. 2001
    ..In addition, SFRP-1 and SFRP-3 are expressed in opposing anterolateral to caudomedial gradients within the telencephalic ventricular zone throughout corticogenesis...
  32. ncbi Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains
    C E Dann
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nature 412:86-90. 2001
    ..This work provides a framework for studies of homologous CRDs in proteins including muscle-specific kinase and Smoothened, a component of the Hedgehog signalling pathway...
  33. ncbi Transcriptional activity of the promoter region of rat frizzled-related protein gene
    J W Yam
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Biochem Biophys Res Commun 286:94-100. 2001
    Frizzled-related protein (Frp) is a new family of secreted proteins involved in tumorigenesis and Wnt-signaling pathway...
  34. ncbi Expression of Tcf/Lef and sFrp and localization of beta-catenin in the developing mouse lung
    M Tebar
    Department of Pulmonology, Leiden University Medical Center, NL 2300 RC, Leiden, The Netherlands
    Mech Dev 109:437-40. 2001
    ..5 onward), and adjacent mesenchyme. Tcf1, Lef1, Tcf3, Tcf4, sFrp1, sFrp2 and sFrp4 were also expressed in the PE, AE, and adjacent mesenchyme in specific spatio-temporal patterns...
  35. ncbi Regulation of Wnt signaling during adipogenesis
    Christina N Bennett
    Department of Physiology, 7620 Medical Science II, University of Michigan Medical School, 1301 E Catherine Street, Ann Arbor, MI 48109 0622, USA
    J Biol Chem 277:30998-1004. 2002
    ..Finally, we demonstrate that disruption of extracellular Wnt signaling by expression of secreted Frizzled related proteins causes spontaneous adipocyte conversion...
  36. ncbi Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation
    Mahua Mukhopadhyay
    Department of Anatomy, University of Wisconsin Madison Medical School, Madison, WI 53706, USA
    Development 130:495-505. 2003
    ..The expression of several Wnt inhibitors is curtailed in the mutant, suggesting that Wnt pathways may be involved in axial patterning regulated by Ldb1...
  37. ncbi Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina
    Hong Liu
    Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Dev Dyn 227:323-34. 2003
    ....
  38. ncbi Members of the Wnt, Fz, and Frp gene families expressed in postnatal mouse cerebral cortex
    Tomomi Shimogori
    Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, Illinois 60637, USA
    J Comp Neurol 473:496-510. 2004
    ..Thus, canonical Wnt signaling could be utilized in a major cortical input by Fz- and Lef1-expressing thalamic cells that innervate the Wnt-expressing cortex...
  39. ncbi Lmx1b expression during joint and tendon formation: localization and evaluation of potential downstream targets
    Sandra D Dreyer
    Department of Pathology and Human Anatomy, Loma Linda University, 24785 Stewart St, Loma Linda, CA 92350, USA
    Gene Expr Patterns 4:397-405. 2004
    ..to developing joints and associated tissues in normal and Lmx1b knockout (KO) mice including: Gdf-5, sFrp2, sFrp3, Six1 and Six2. Lmx1b was diffusely expressed in the undifferentiated dorsal mesoderm of the emerging limb bud (E9...
  40. ncbi The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis
    Robert G Kelly
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Hum Mol Genet 13:2829-40. 2004
    ..While no abnormalities in branchiomeric myogenesis were detected in Tbx1(+/-) mice, reduced TBX1 levels may contribute to pharyngeal hypotonia in del22q11.2 patients...
  41. ncbi Fritz: a secreted frizzled-related protein that inhibits Wnt activity
    T Mayr
    Max Planck Institut für physiologische, Bad Nauheim, Germany
    Mech Dev 63:109-25. 1997
    ..Here we describe the cloning and characterization of Fritz, a mouse (mfiz) and human (hfiz) gene which codes for a secreted protein that is structurally related to the ..