fructose transporter


Gene Symbol: fructose transporter
Description: solute carrier family 2 (facilitated glucose transporter), member 5
Alias: AI526984, Glut5, Slc5a, solute carrier family 2, facilitated glucose transporter member 5, GLUT-5, fructose transporter, glucose transporter type 5, small intestine
Species: mouse
Products:     fructose transporter

Top Publications

  1. Barone S, Fussell S, Singh A, Lucas F, Xu J, Kim C, et al. Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension. J Biol Chem. 2009;284:5056-66 pubmed publisher
    ..Here we demonstrate that Glut5 (Slc2a5) deletion reduced fructose absorption by approximately 75% in the jejunum and decreased the concentration ..
  2. Patel C, Douard V, Yu S, Gao N, Ferraris R. Transport, metabolism, and endosomal trafficking-dependent regulation of intestinal fructose absorption. FASEB J. 2015;29:4046-58 pubmed publisher
    ..We hypothesized that glucose transporter (GLUT) protein, member 5 (GLUT5) is the primary fructose transporter and that fructose absorption via GLUT5, metabolism via ketohexokinase (KHK), as well as GLUT5 trafficking ..
  3. Dotimas J, Lee A, Schmider A, Carroll S, Shah A, Bilen J, et al. Diabetes regulates fructose absorption through thioredoxin-interacting protein. elife. 2016;5: pubmed publisher
    ..Our results indicate that Txnip is a critical regulator of fructose metabolism and suggest that a diabetic state can promote fructose uptake. ..
  4. Wu X, Wang X, Gao J, Yu Y, Jia S, Zheng J, et al. Glucose transporter 5 is undetectable in outer hair cells and does not contribute to cochlear amplification. Brain Res. 2008;1210:20-8 pubmed publisher
    Glucose transporter 5 (Glut5) is a high-affinity fructose transporter. It was proposed to be a motor protein or part of the motor complex required for cochlear amplification in outer hair cells (OHCs)...
  5. Sakakura Y, Shibui T, Irie K, Yajima T. Metabolic mode peculiar to Meckel's cartilage: immunohistochemical comparisons of hypoxia-inducible factor-1alpha and glucose transporters in developing endochondral bones in mice. Eur J Oral Sci. 2008;116:341-52 pubmed publisher
    ..HIF-1alpha), glucose transporter 1 (GLUT1), glucose transporter 3 (GLUT3), and glucose transporter 5 (GLUT5), and using enzyme histochemistry for glucose-6-phosphate isomerase (GPI), lactate dehydrogenase (LDH), and ..
  6. Du L, Heaney A. Regulation of adipose differentiation by fructose and GluT5. Mol Endocrinol. 2012;26:1773-82 pubmed
    ..We further show that the key fructose transporter, GluT5, is expressed in early-stage adipocyte differentiation but is not expressed in mature adipocytes...
  7. Patel C, Douard V, Yu S, Tharabenjasin P, Gao N, Ferraris R. Fructose-induced increases in expression of intestinal fructolytic and gluconeogenic genes are regulated by GLUT5 and KHK. Am J Physiol Regul Integr Comp Physiol. 2015;309:R499-509 pubmed publisher
    ..genetic mouse models to test the hypothesis that fructose absorption via glucose transporter protein, member 5 (GLUT5), metabolism via ketohexokinase (KHK), as well as GLUT5 trafficking to the apical membrane via the Ras-related ..
  8. Patel C, Sugimoto K, Douard V, Shah A, Inui H, Yamanouchi T, et al. Effect of dietary fructose on portal and systemic serum fructose levels in rats and in KHK-/- and GLUT5-/- mice. Am J Physiol Gastrointest Liver Physiol. 2015;309:G779-90 pubmed publisher
    ..that diet-induced changes in blood fructose concentrations are regulated by ketohexokinase (KHK) and the fructose transporter GLUT5...
  9. Palavicino Maggio C, Kuzhikandathil E. Dietary Fructose and GLUT5 Transporter Activity Contribute to Antipsychotic-Induced Weight Gain. Schizophr Bull. 2016;42:1270-9 pubmed publisher
    ..Weight gain was determined in wild type mice and mice lacking the GLUT5 fructose transporter that were "orally-administered" 20mg/kg clozapine for 28 days...

More Information


  1. Fatima J, Iqbal C, Houghton S, Kasparek M, Duenes J, Zheng Y, et al. Hexose transporter expression and function in mouse small intestine: role of diurnal rhythm. J Gastrointest Surg. 2009;13:634-41 pubmed publisher
    ..aim of the study was to investigate the diurnal expression and function of hexose transporters SGLT1, GLUT2, and GLUT5 in mouse small bowel...
  2. Jones H, Butler R, Brooks D. Intestinal fructose transport and malabsorption in humans. Am J Physiol Gastrointest Liver Physiol. 2011;300:G202-6 pubmed publisher
    ..The major transporter for fructose in intestinal epithelial cells is thought to be the facilitative transporter GLUT5. Consistent with a facilitative transport system, we show here by analysis of past studies on healthy adults that ..
  3. Kishida K, Pearce S, Yu S, Gao N, Ferraris R. Nutrient sensing by absorptive and secretory progenies of small intestinal stem cells. Am J Physiol Gastrointest Liver Physiol. 2017;312:G592-G605 pubmed publisher
  4. Corpe C, Bovelander F, Munoz C, Hoekstra J, Simpson I, Kwon O, et al. Cloning and functional characterization of the mouse fructose transporter, GLUT5. Biochim Biophys Acta. 2002;1576:191-7 pubmed
    Mouse GLUT5 cDNA and a 7.7-kb genomic fragment have been isolated and characterized. The cDNA sequence suggests mouse GLUT5 is composed of 501 amino acids, and has 69-88% amino acid identity with human, rat, and rabbit GLUT5...
  5. Singh A, Amlal H, Haas P, Dringenberg U, Fussell S, Barone S, et al. Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5. Kidney Int. 2008;74:438-47 pubmed publisher
    ..fructose intake enhanced expression of this transporter as well as the fructose-absorbing transporter Slc2a5 (Glut5) in the small intestine of wild type mice...
  6. Sakar Y, Nazaret C, Letteron P, Ait Omar A, Avenati M, Viollet B, et al. Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents. PLoS ONE. 2009;4:e7935 pubmed publisher
    ..In this study, we determine the effects of luminal leptin on activity/expression of GLUT2 and GLUT5 transporters in response to sugars intake and analyse their physiological consequences...
  7. Chauvin T, Xie F, Liu T, Nicora C, Yang F, Camp D, et al. A systematic analysis of a deep mouse epididymal sperm proteome. Biol Reprod. 2012;87:141 pubmed publisher
    ..This proteome should prove a useful tool for assembly and testing of protein networks important for sperm function. ..