Gene Symbol: Frat3
Description: paternally expressed 12
Alias: Frat3, paternally expressed 12, frequently rearranged in advanced T-cell lymphomas 3
Species: mouse
Products:     Frat3

Top Publications

  1. Stefan M, Simmons R, Bertera S, Trucco M, Esni F, Drain P, et al. Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome. Am J Physiol Endocrinol Metab. 2011;300:E909-22 pubmed publisher
  2. Nakagaki A, Osanai H, Kishino T. Imprinting analysis of the mouse chromosome 7C region in DNMT1-null embryos. Gene. 2014;553:63-8 pubmed publisher
    ..The imprinted domain contains paternally expressed genes, Snurf/Snrpn, Ndn, Magel2, Mkrn3, and Frat3, C/D-box small nucleolar RNAs (snoRNAs), and the maternally expressed gene, Ube3a...
  3. Kobayashi S, Kohda T, Ichikawa H, Ogura A, Ohki M, Kaneko ishino T, et al. Paternal expression of a novel imprinted gene, Peg12/Frat3, in the mouse 7C region homologous to the Prader-Willi syndrome region. Biochem Biophys Res Commun. 2002;290:403-8 pubmed
    ..A novel imprinted gene, Peg12/Frat3, was identified along with 10 previously known Pegs...
  4. van Amerongen R, van der Gulden H, Bleeker F, Jonkers J, Berns A. Characterization and functional analysis of the murine Frat2 gene. J Biol Chem. 2004;279:26967-74 pubmed
    ..To date two Frat homologues have been described in the mouse, Frat1 and Frat3. The proteins encoded by these two genes are 84% identical...
  5. Chai J, Locke D, Ohta T, Greally J, Nicholls R. Retrotransposed genes such as Frat3 in the mouse Chromosome 7C Prader-Willi syndrome region acquire the imprinted status of their insertion site. Mamm Genome. 2001;12:813-21 pubmed
    ..Bioinformatic analyses identified a BAC containing four genes, Mkrn3, Magel2, Ndn, Frat3, and the Atp5l-ps1 pseudogene, the latter two genes derived from recent L1-mediated retrotransposition...
  6. Bechard M, Trost R, Singh A, Dalton S. Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3? subcellular localization in pluripotent cells. Mol Cell Biol. 2012;32:288-96 pubmed publisher
    ..These findings provide new links between PI3K/Akt signaling and regulation of Gsk3? activity by Frat, an oncogene previously shown to cooperate with Myc in tumorigenesis. ..
  7. Jonkers J, van Amerongen R, van der Valk M, Robanus Maandag E, Molenaar M, Destree O, et al. In vivo analysis of Frat1 deficiency suggests compensatory activity of Frat3. Mech Dev. 1999;88:183-94 pubmed
    ..Tissues of homozygous Frat1(lacZ) mice showed expression of a second mouse Frat gene, designated Frat3. The Frat1 and Frat3 proteins are structurally and functionally very similar, since both Frat1 and Frat3 are ..
  8. van Amerongen R, Nawijn M, Franca Koh J, Zevenhoven J, van der Gulden H, Jonkers J, et al. Frat is dispensable for canonical Wnt signaling in mammals. Genes Dev. 2005;19:425-30 pubmed
    ..These studies show that Frat is not an essential component of the canonical Wnt pathway in higher organisms, despite the strict requirement of Frat/GBP for maternal Wnt signaling in Xenopus. ..
  9. Skryabin B, Gubar L, Seeger B, Pfeiffer J, Handel S, Robeck T, et al. Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation. PLoS Genet. 2007;3:e235 pubmed publisher
    ..This is the first example in a multicellular organism of genetic deletion of a C/D box snoRNA gene resulting in a pronounced phenotype. ..

More Information


  1. Resnick J, Nicholls R, Wevrick R. Recommendations for the investigation of animal models of Prader-Willi syndrome. Mamm Genome. 2013;24:165-78 pubmed publisher
    ..Here, we summarize the goals of the AMWG, describe current animal models of PWS, and make recommendations for strategies to maximize the utility of animal models and for the development and use of new animal models of PWS. ..
  2. Messerschmidt D, DE VRIES W, Ito M, Solter D, Ferguson Smith A, Knowles B. Trim28 is required for epigenetic stability during mouse oocyte to embryo transition. Science. 2012;335:1499-502 pubmed publisher
    ..Our results reveal the long-range effects of a maternal gene deletion on epigenetic memory and illustrate the delicate equilibrium of maternal and zygotic factors during nuclear reprogramming. ..