Genomes and Genes
Gene Symbol: Foxg1
Description: forkhead box G1
Alias: 2900064B05Rik, BF-1, Bf1, Hfh9, Hfhbf1, HNF-3/forkhead homolog, brain factor 1, brain factor 1, forkhead box protein G1, forkhead-related protein FKHL1
- The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner earAmy E Kiernan
The Jackson Laboratory, Bar Harbor, Maine, USA
PLoS Genet 2:e4. 2006..These data demonstrate that JAG1-mediated Notch signaling is essential during early development for establishing the prosensory regions of the inner ear...
- Foxg1 is required for morphogenesis and histogenesis of the mammalian inner earSarah Pauley
Creighton University, Department of Biomedical Sciences, Omaha, Nebraska 68178, USA
Dev Dyn 235:2470-82. 2006..Several Fox genes (Foxi1, Foxg1) are expressed in the developing otocyst of both zebrafish and mammals...
- Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3Vassiliki Fotaki
Genes and Development Group, Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
J Neurosci 26:9282-92. 2006..We observed occasional cells with diencephalic character in the Foxg1 (forkhead box)-expressing Gli3(Xt/Xt) telencephalon at embryonic day 10...
- Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1Nuria Flames
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 San Joan d Alacant, Spain
Neuron 44:251-61. 2004..These observations provide evidence that Neuregulin-1 and its ErbB4 receptor directly control neuronal migration in the nervous system...
- Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrainChristopher A Fasano
Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208 USA
Genes Dev 23:561-74. 2009..We show that forebrain NSCs require the forebrain-specific transcription factor Foxg1 for Bmi-1-dependent self-renewal, and that repression of p21 is a focus of this interaction...
- Human brain factor 1, a new member of the fork head gene familyD B Murphy
Institut fur Humangenetik, Gottingen, Germany
Genomics 21:551-7. 1994..The cDNA HFK1 has a length of 2557 nucleotides and shows strong homology at the nucleotide level (91.2%) to brain factor 1 (BF-1) from rat. The HFK1 cDNA codes for a putative 476 amino acid protein...
- Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner earRachael Brooker
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Development 133:1277-86. 2006..Our findings confirm that Notch signalling in the ear has distinct prosensory and lateral-inhibitory functions, for which different ligands are primarily responsible...
- FGFR1 is required for the development of the auditory sensory epitheliumUlla Pirvola
Institute of Biotechnology, 00014 University of Helsinki, Helsinki, Finland
Neuron 35:671-80. 2002..Full inactivation of Fgfr1 in the inner ear epithelium by Foxg1-Cre-mediated deletion leads to an 85% reduction in the number of auditory hair cells...
- Brain factor-1 controls the proliferation and differentiation of neocortical progenitor cells through independent mechanismsCarina Hanashima
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
J Neurosci 22:6526-36. 2002The winged helix gene Brain factor-1 (BF1) has a pleiotropic role in the development of the cerebral hemispheres of the brain. Mice lacking BF1 have defects in the morphogenesis of the structures of the dorsal telencephalon (e.g...
- Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila HmxWeidong Wang
Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
Dev Cell 7:439-53. 2004....
- The transcription factor Foxg1 regulates the competence of telencephalic cells to adopt subpallial fates in miceMartine Manuel
Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
Development 137:487-97. 2010b>Foxg1 is required for development of the ventral telencephalon in the embryonic mammalian forebrain...
- Dose-dependent functions of Fgf8 in regulating telencephalic patterning centersElaine E Storm
Department of Anatomy, University of California, San Francisco, CA 94143 2711, USA
Development 133:1831-44. 2006..We provide evidence that the hypoplasia results from decreased Foxg1 expression, reduced cell proliferation and increased cell death...
- The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcriptionJ Yao
Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
Mol Cell Biol 21:1962-72. 2001b>Brain factor 1 (BF-1) is a winged-helix transcriptional repressor that plays important roles in both progenitor cell differentiation and regional patterning in the mammalian telencephalon...
- Notch 1 inhibits photoreceptor production in the developing mammalian retinaAshutosh P Jadhav
Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Development 133:913-23. 2006..These cone enriched mutant mice should prove to be a valuable resource for the study of this relatively rare mammalian photoreceptor cell type...
- Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiationNathalie Marcal
Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Mol Cell Biol 25:10916-29. 2005..In particular, Gro/TLE1 interacts with forkhead transcription factor brain factor 1 (BF-1; also termed FoxG1)...
- Development of midline cell types and commissural axon tracts requires Fgfr1 in the cerebrumShubha Tole
Department of Biological Sciences, Room B304, Tata Institute of Fundamental Research, Colaba, Mumbai, India
Dev Biol 289:141-51. 2006....
- FGF signaling through FGFR1 is required for olfactory bulb morphogenesisJean M Hebert
Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
Development 130:1101-11. 2003..Together the results demonstrate an essential role for Fgfr1 in patterning and morphogenesis of the telencephalon...
- The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner earAmy E Kiernan
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Development 132:4353-62. 2005..Our results demonstrate that the Notch pathway plays a dual role in regulating cellular differentiation and patterning in the cochlea, acting both through lateral inhibition and the control of cellular proliferation...
- Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosisBen Martynoga
Genes and Development Group, Biomedical Sciences, George Square, The University of Edinburgh, Edinburgh EH8 9XD, UK
Dev Biol 283:113-27. 2005Null mutation of the Foxg1 gene causes hypoplasia of the mouse telencephalon and loss of ventral telencephalic structures. We show that a crucial early requirement for Foxg1 is in the induction of ventral cell fate in the telencephalon...
- Foxg1 confines Cajal-Retzius neuronogenesis and hippocampal morphogenesis to the dorsomedial palliumLuca Muzio
Department of Biological and Technological Research, San Raffaele Scientific Institute, 20132 Milan, Italy
J Neurosci 25:4435-41. 2005..b>Foxg1, encoding for one of these factors, previously was reported to be necessary for basal ganglia morphogenesis, ..
- Foxg1 suppresses early cortical cell fateCarina Hanashima
Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
Science 303:56-9. 2004..of the earliest born neurons, the Cajal-Retzius cells, is suppressed by the telencephalic transcription factor Foxg1. In Foxg1 null mutants, we observed an excess of Cajal-Retzius neuron production in the cortex...
- Fibroblast growth factor receptor 1 is required for the proliferation of hippocampal progenitor cells and for hippocampal growth in mouseYasushi Ohkubo
Child Study Center, Yale University, New Haven, Connecticut 06520, USA
J Neurosci 24:6057-69. 2004..We conclude that Fgfr1 is necessary for hippocampal growth, because it promotes the proliferation of hippocampal progenitors and stem cells during development...
- BF-1 interferes with transforming growth factor beta signaling by associating with Smad partnersC Dou
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Mol Cell Biol 20:6201-11. 2000The winged-helix (WH) BF-1 gene, which encodes brain factor 1 (BF-1) (also known as foxg1), is essential for the proliferation of the progenitor cells of the cerebral cortex...
- Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structuresJ M Hebert
Department of Biological Sciences, Stanford University, Stanford, California, 94305 5020, USA
Dev Biol 222:296-306. 2000..A mouse line was produced in which cre was targeted to the Foxg1 (BF-1) locus, a gene expressed specifically in the telencephalon and discrete head structures...
- Dual role of brain factor-1 in regulating growth and patterning of the cerebral hemispheresC L Dou
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Cereb Cortex 9:543-50. 1999..These results raise the possibility that BF-1 may modulate both progenitor cell proliferation and regional patterning by regulating the expression or activity of inductive signals which act on the telencephalic neuroepithelium...
- Expression of winged helix genes, BF-1 and BF-2, define adjacent domains within the developing forebrain and retinaV Hatini
Cell Biology and Genetics Program, Sloan Kettering Division, Cornell University Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10021
J Neurobiol 25:1293-309. 1994..These observations suggest that in addition to playing a role in the subdivision of the forebrain, these two WH factors may also function to establish positional information in the retinal neuroepithelium...
- Inductive interactions direct early regionalization of the mouse forebrainK Shimamura
Department of Psychiatry and Langley Porter Psychiatric Institute, University of California at San Francisco, 94143 0984, USA
Development 124:2709-18. 1997..The anterior neural ridge is essential for expression of BF1, a gene encoding a transcription factor required for regionalization and growth of the telencephalic and optic ..
- Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damageNicole Arbour
Department of Biochemistry, Microbiology, and Immunology, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
J Neurosci 28:6068-78. 2008..Together, our results are the first to demonstrate the requirement of Mcl-1, an anti-apoptotic Bcl-2 family protein, for cortical neurogenesis and the survival of neurons after DNA damage...
- Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheresS Xuan
Cell Biology and Genetics Program, Cornell University Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Neuron 14:1141-52. 1995..These results suggest that BF-1 controls the morphogenesis of the telencephalon by regulating the rate of neuroepithelial cell proliferation and the timing of neuronal differentiation...
- Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brainW Tao
Division of Endocrinology, Memorial Sloan Kettering Cancer Center, New York, New York 10021
Neuron 8:957-66. 1992..The expression of fork head is restricted to the anterior and posterior termini of the early fly embryo. Brain factor 1 (BF-1) is a new member of this family isolated from rat brain with an expression pattern and DNA binding ..
- FGF signalling generates ventral telencephalic cells independently of SHHGrigoriy Gutin
Departments of Neuroscience and Molecular Genetics, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
Development 133:2937-46. 2006..Moreover, the Fgfr1;Fgfr2 phenotype, unlike the Shh phenotype, is not rescued by loss of Gli3, further indicating that FGFs act downstream of Shh and Gli3 to generate ventral telencephalic cell types...
- Disrupted development of the cerebral hemispheres in transgenic mice expressing the mammalian Groucho homologue transducin-like-enhancer of split 1 in postmitotic neuronsJ Yao
Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Canada
Mech Dev 93:105-15. 2000..These results provide the first direct evidence that TLE1 is an important negative regulator of postmitotic neuronal differentiation in the mammalian central nervous system...
- Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defectsM Ishibashi
Institute for Immunology, Kyoto University Faculty of Medicine, Japan
Genes Dev 9:3136-48. 1995..These results suggest that HES-1 normally controls the proper timing of neurogenesis and regulates neural tube morphogenesis...
- Dorsal-ventral patterning defects in the eye of BF-1-deficient mice associated with a restricted loss of shh expressionS Huh
Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, 10021, USA
Dev Biol 211:53-63. 1999b>Brain factor 1 (BF-1) is a winged-helix transcription factor with restricted expression in the anterior optic vesicle and in the telencephalic neuroepithelium of the neural tube...
- Hmx2 homeobox gene control of murine vestibular morphogenesisW Wang
Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
Development 128:5017-29. 2001....
- Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigationGuillermina López-Bendito
Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
Cell 125:127-42. 2006..These results show that neuronal tangential migration constitutes a novel mechanism to control the timely arrangement of guidance cues required for axonal tract formation in the mammalian brain...
- Foxd1 is required for proper formation of the optic chiasmEloisa Herrera
Departments of Pathology, Anatomy and Cell Biology and Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Development 131:5727-39. 2004..retina, proteins designating the ipsilateral projection, such as Zic2 and EphB1, are missing, and the domain of Foxg1 (BF-1) expands from nasal retina into the VT crescent...
- The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesisNathalie G Berube
Molecular Medicine Programs, Ottawa Health Research Institute, Ottawa, Ontario, Canada
J Clin Invest 115:258-67. 2005..Taken together, our results indicate that ATRX is a critical mediator of cell survival during early neuronal differentiation. Thus, increased neuronal loss may contribute to the severe mental retardation observed in human patients...
- Ciliary proteins link basal body polarization to planar cell polarity regulationChonnettia Jones
Department of Cell Biology, Emory University School of Medicine, 615 Michael St, Atlanta, Georgia 30322, USA
Nat Genet 40:69-77. 2008..Thus, our data uncover a distinct requirement for ciliary genes in basal body positioning and morphological polarization during PCP regulation...
- BMP signalling inhibits premature neural differentiation in the mouse embryoAida Di-Gregorio
Molecular Embryology Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK
Development 134:3359-69. 2007..Together, our results demonstrate that inhibition of BMP signalling has a central role during neural induction in mammals and suggest that FGFs do not act as neural inducers in the post-implantation mouse embryo...
- Transcription factor Foxd1 is required for the specification of the temporal retina in mammalsMaria Isabel Carreres
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas y Universidad Miguel Hernández, Campus San Juan de Alicante, 03550 Alicante, Spain
J Neurosci 31:5673-81. 2011..Overall, these results indicate that Foxd1 functions as a conserved determinant of temporal identity but reveal that the downstream effectors, and likely their mechanisms of action, are different in mammals and birds...
- The neural progenitor-specifying activity of FoxG1 is antagonistically regulated by CKI and FGFTarik Regad
The Wellcome Trust Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge, CB2 1QR, UK
Nat Cell Biol 9:531-40. 2007b>FoxG1 is an evolutionarily conserved, winged-helix transcriptional repressor that maintains progenitor cells in the vertebrate forebrain. How the activity of FoxG1 is regulated is not known...
- Glypicans are differentially expressed during patterning and neurogenesis of early mouse brainGuillaume Luxardi
IBDML CNRS UMR 6216, INSERM UMR623, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
Biochem Biophys Res Commun 352:55-60. 2007..The novel expression sites of glypicans shown here contribute to the identification of signalling molecules involved in brain patterning...
- CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouseMasayuki Uehara
Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, Osaka 565 0871, Japan
Dev Biol 302:399-411. 2007....
- Loss of orphan nuclear receptor GCNF function disrupts forebrain development and the establishment of the isthmic organizerArthur C K Chung
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Dev Biol 293:13-24. 2006..Increased cell death may contribute to the loss of midbrain structure in GCNF-/- embryos. These results indicate that GCNF is required for establishment of the isthmic organizer, thereby regulating the midbrain development...
- Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortexAlessandro Sessa
Molecular Neuropathology Laboratory, SCRI, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
Neuron 60:56-69. 2008..Together, these findings identify Tbr2 as a critical factor for the specification of IPCs during corticogenesis...
- Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarismEzat Sajedi
Neural Development Unit, Institute of Child Health, University College London, London, UK
Dis Model Mech 1:241-54. 2008..Together, these results suggest that the I26T mutation yields a hypomorphic allele, whereas R160C produces a null allele and, consequently, a more severe phenotype in both mice and humans...
- Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal developmentJoseph A Brzezinski
University of Washington, Department of Biological Structure, Seattle, WA 98195, USA
Development 137:619-29. 2010..We conclude that Blimp1 regulates the decision between photoreceptor and bipolar cell fates in the Otx2(+) cell population during retinal development...
- FoxG1 promotes the survival of postmitotic neuronsSomasish Ghosh Dastidar
Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas 75080, USA
J Neurosci 31:402-13. 2011The transcription factor FoxG1 regulates neurogenesis in the embryonic telencephalon as well as a number of other neurodevelopmental processes...
- Sp8 is crucial for limb outgrowth and neuropore closureSheila M Bell
Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Proc Natl Acad Sci U S A 100:12195-200. 2003..These observations indicate that Sp8 functions downstream of Wnt3, Fgf10, and Bmpr1a in the signaling cascade that mediates AER formation...
- The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formationJ P Martinez Barbera
Division of Mammalian Development, National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
Development 127:2433-45. 2000..All together, these results demonstrate that Hex function is essential in definitive endoderm for normal development of the forebrain, liver and thyroid gland...
- Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain developmentY Furuta
Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
Development 124:2203-12. 1997..Bmp co-expression overlaps that of Msx1 and Hfh4, and is complementary to that of Bf1. The domain of Bmp co-expression is also associated with limited growth of the neuroectoderm, as revealed by ..
- The small GTPase Rac1 regulates auditory hair cell morphogenesisCynthia M Grimsley-Myers
Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
J Neurosci 29:15859-69. 2009..Together, these results reveal a critical function of Rac1 in morphogenesis of the auditory sensory epithelium and stereociliary bundle...
- BMP signaling is required locally to pattern the dorsal telencephalic midlineJean M Hebert
Department of Biological Sciences, Stanford University, 385 Serra Mall, CA 94305, USA
Neuron 35:1029-41. 2002..Our data fail to support a more global, concentration-dependent role in specifying telencephalic cell fates...
- Foxg1 is required for proper separation and formation of sensory cristae during inner ear developmentChan Ho Hwang
Lab of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA
Dev Dyn 238:2725-34. 2009..Here, we analyzed the inner ears of Foxg1(-/-) mouse mutants, which display vestibular defects that are in conflict with the above model...
- Visualizing the distribution of synapses from individual neurons in the mouse brainLing Li
Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, California, United States of America
PLoS ONE 5:e11503. 2010..To understand how complex neural circuits function, it is crucial to precisely describe neuronal connectivity and the distributions of synapses to and from individual neurons...
- Longitudinal organization of the anterior neural plate and neural tubeK Shimamura
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco 94143 0984, USA
Development 121:3923-33. 1995....
- Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain developmentOleg V Lagutin
Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
Genes Dev 17:368-79. 2003..Furthermore, these results support the hypothesis that a Wnt signal gradient specifies posterior fates in the anterior neural plate...
- Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Ptx1Nicoletta Bobola
Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
Development 130:3403-14. 2003....
- Targeted connexin26 ablation arrests postnatal development of the organ of CortiYunfeng Wang
Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
Biochem Biophys Res Commun 385:33-7. 2009..These results demonstrated that Cx26 plays essential roles in postnatal maturation and homoeostasis of the organ of Corti before the onset of hearing...
- Paleocortex is specified in mice in which dorsal telencephalic patterning is severely disruptedAditee Vyas
Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
J Comp Neurol 466:545-53. 2003..In contrast, when the ventral telencephalon is almost completely deleted, such as in the BF1-/- brain, paleocortical markers are undetectable...
- Anterior neural plate regionalization in cripto null mutant mouse embryos in the absence of node and primitive streakGiovanna L Liguori
Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Via Guglielmo Marconi 12, 80125 Naples, Italy
Dev Biol 264:537-49. 2003..These results suggest that, in mouse embryos, the specification of the anterior neural identities can be maintained without an absolute requirement for the embryonic mesoderm and the node...
- Wnt/β-catenin signaling is disrupted in the extra-toes (Gli3(Xt/Xt) ) mutant from early stages of forebrain development, concomitant with anterior neural plate patterning defectsVassiliki Fotaki
Genes and Development Group, Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
J Comp Neurol 519:1640-57. 2011..Our data reveal that Gli3 is required at the neural plate stage to regulate Wnt expression and Wnt/β-catenin signaling in the presumptive forebrain and confirm its previously proposed role in patterning the anterior neural plate...
- FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8aLisa D Urness
Department of Human Genetics, University of Utah, 15 N 2030 E, RM 2100, Salt Lake City, UT 84112 5330, USA
Dev Biol 340:595-604. 2010..Several genes in the down-regulated class, including Hmx3, Hmx2, Foxg1, Sox9, Has2, and Slc26a9 were validated by in situ hybridization...
- Early forebrain wiring: genetic dissection using conditional Celsr3 mutant miceLibing Zhou
Developmental Neurobiology, Universite Catholique de Louvain, 1200 Bruxelles, Belgique
Science 320:946-9. 2008..These observations provide in vivo evidence that Celsr3-mediated interactions between axons and guidepost cells govern axonal tract formation in mammals...
- ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brainKristin D Kernohan
Department of Paediatrics, 800 Commissioners Road East, London, ON N6C 2V5, Canada
Dev Cell 18:191-202. 2010..We propose that ATRX, cohesin, and MeCP2 cooperate to silence a subset of imprinted genes in the postnatal mouse brain...
- Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesisYina Li
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 4114 MRB3, Nashville, TN 37232, USA
Dev Biol 322:145-55. 2008..Our finding sheds light on human tracheal malformations by providing a novel mouse model implicating Bmp signaling, non-canonical Erk activation and cellular proliferation...
- Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39Julie M Schultz
Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
Am J Hum Genet 85:25-39. 2009..Overexpression of HGF is associated with progressive degeneration of outer hair cells in the cochlea, whereas cochlear deletion of Hgf is associated with more general dysplasia...
- Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrainR W Stottmann
Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Dev Biol 335:166-78. 2009..Finally, we evaluate Wnt signaling but do not find evidence that this plays a role in causing the perturbed neurodevelopmental phenotype we describe...
- Differential requirements for Fgf3 and Fgf8 during mouse forebrain developmentThomas Theil
Centres for Neuroscience Research and Integrative Physiology, University of Edinburgh, Edinburgh, Scotland
Dev Dyn 237:3417-23. 2008..Therefore unlike in zebrafish, Fgf3 is not required for mouse forebrain development whereas Fgf8 has a central role during this process...
- Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endodermDario Acampora
CEINGE Biotecnologie Avanzate, 80145 Naples, Italy
Mech Dev 126:882-97. 2009....
- FGF signaling is strictly required to maintain early telencephalic precursor cell survivalHunki Paek
Departments of Neuroscience and Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Development 136:2457-65. 2009..Together with previous gain-of-function studies showing induction of Foxg1 expression and mirror-image duplications of the cortex by exogenous FGF8, our loss-of-function results suggest ..
- Sox9 is required for invagination of the otic placode in miceFrancisco Barrionuevo
Institute of Human Genetics and Anthropology, University of Freiburg, Breisacherstr 33, D 79106 Freiburg, Germany
Dev Biol 317:213-24. 2008..We show that in mice with a Foxg1(Cre)-mediated conditional inactivation of Sox9 in the otic ectoderm, otic placodes form and express markers of ..
- Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epitheliumSteve Rodriguez
Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
Dev Biol 314:40-58. 2008....
- Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain familyD E Clevidence
Department of Biochemistry M C 536, University of Illinois College of Medicine, Chicago 60612
Proc Natl Acad Sci U S A 90:3948-52. 1993..The HNF-3/fkh motif therefore comprises a large gene family of transcription factors that play a role in tissue-specific gene regulation and development...
- Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4Perry J Blackshear
Office of Clinical Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Development 130:4539-52. 2003..These findings may be relevant to human congenital hydrocephalus, a birth defect that affects approximately 0.6 per 1000 newborns...
- A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryoMakoto Ishibashi
Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Development 129:4807-19. 2002....
- Goosecoid and cerberus-like do not interact during mouse embryogenesisAna C Borges
Instituto Gulbenkian de Ciencia, Oeiras, Portugal
Int J Dev Biol 46:259-62. 2002..In conclusion, the analysis carried out indicated that gsc does not compensate for cer-l loss-of-function and that these genes do not interact genetically...
- Emx2 directs the development of diencephalon in cooperation with Otx2Y Suda
Department of Morphogenesis, Institute of Molecular Embryology and Genetics IMEG, Kumamoto University, Japan
Development 128:2433-50. 2001..Consequently, development of the dorsal and ventral thalamus and anterior pretectum requires cooperation between Emx2 and Otx2, whereas Emx2 expression is incompatible with development of the commissural region of the pretectum...
- BMP4 is essential for lens induction in the mouse embryoY Furuta
Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175 USA
Genes Dev 12:3764-75. 1998..Based on these results we propose that BMP4 is required for the optic vesicle to manifest its lens-inducing activity, by regulating downstream genes and/or serving as one component of multiple inductive signals...
- Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulationD Acampora
International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, Italy
Development 125:5091-104. 1998..Moreover, our data lead us to hypothesize that the differential post-transcriptional control existing between VE and epiblast cells may potentially contribute to fundamental regulatory mechanisms required for head specification...
- Characterization of the structure and function of the gene for transcription factor BF-1, an essential regulator of forebrain developmentH Li
Molecular Biology Program, Sloan Kettering Division, Cornell University Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Brain Res Mol Brain Res 37:96-104. 1996..Using these cells, we demonstrate that the genomic region between -3.7kb and -79 bp upstream of the P1 promoter contains cell-specific enhancer activity in transient transfection assays...
- A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brainS L Ang
Institute de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Illkirch, C U de Strasbourg, France
Development 122:243-52. 1996....
- The winged helix transcription factor Foxg1 facilitates retinal ganglion cell axon crossing of the ventral midline in the mouseThomas Pratt
Genes and Development Group, Biomedical Sciences, George Square, The University of Edinburgh, Edinburgh EH8 9XD, UK
Development 131:3773-84. 2004..The transcription factor Foxg1 (also known as BF1) is expressed at several key locations along this pathway...
- Temporal requirement for hedgehog signaling in ventral telencephalic patterningMarc Fuccillo
Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
Development 131:5031-40. 2004..events, we directed the removal of hedgehog signaling within the brain by embryonic day 9 of development, using a FoxG1(Cre) driver line to mediate the removal of a conditional smoothened null allele...
- The mouse ADP-ribosylation factor-like 4 gene: two separate promoters direct specific transcription in tissues and testicular germ cellS Jacobs
Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät der Rheinisch Westfälischen Technischen Hochschule Aachen, Wendlingweg 2, D 52057 Aachen, Germany
Biochem J 335:259-65. 1998..Chem. 269, 15683-15688]. The Arl4 gene maps to the proximal region of mouse chromosome 12 linked to Lamb1-1, Hfhbf1 and Sos2...
- Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochleaBonnie E Jacques
Section on Developmental Neuroscience, Porter Neuroscience Research Center, 35 Convent Dr, Room 2A 100, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
Development 134:3021-9. 2007..These results suggest that PCs might exist in a transient state of differentiation that makes them potential targets for regenerative therapies...
- Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patientsJelena S Arnold
Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Hum Mol Genet 15:1629-39. 2006..first pharyngeal pouch (PPI) in forming outer and middle ears, we tissue-specifically inactivated the gene using Foxg1-Cre. In the conditional mutants, PPI failed to outgrow, preventing the middle ear bone condensations from forming...
- Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery developmentZhen Zhang
Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
Development 132:5307-15. 2005..We also thereby demonstrate conclusively that the role of Tbx1 in fourth PAA development is cell non-autonomous...
- Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical developmentKerry L Ferguson
Ottawa Health Research Institute, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada K1H 8M5
EMBO J 21:3337-46. 2002..Animals carrying a floxed Rb allele were interbred with mice in which cre was knocked into the Foxg1 locus...
- Foxg1 regulates retinal axon pathfinding by repressing an ipsilateral program in nasal retina and by causing optic chiasm cells to exert a net axonal growth-promoting activityNatasha M Tian
Centre for Integrative Physiology, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
Development 135:4081-9. 2008..We investigate how development of these patterns of projection is regulated by the contralateral determinant Foxg1, a forkhead box transcription factor expressed in nasal retina and at the chiasm...
- Chordin and noggin promote organizing centers of forebrain development in the mouseRyan M Anderson
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710 3709, USA
Development 129:4975-87. 2002..These results indicate that the BMP antagonists chordin and noggin promote the inductive and trophic activities of rostral organizing centers in early development of the mammalian head...
- MicroRNA-9 modulates Cajal-Retzius cell differentiation by suppressing Foxg1 expression in mouse medial palliumMikihito Shibata
Laboratory for Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, Chuo Ku, Kobe 650 0046, Japan
J Neurosci 28:10415-21. 2008..Here we propose that mouse microRNA-9 (miR-9) targets Foxg1 mRNAs for proper generation of Cajal-Retzius cells in the medial pallium...
- Neurotrophin-3 is required for appropriate establishment of thalamocortical connectionsLong Ma
Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Neuron 36:623-34. 2002..These results implicate neurotrophins in the critical stage of precise thalamocortical connections...
- Emx1 and Emx2 functions in development of dorsal telencephalonM Yoshida
Department of Morphogenesis, Institute of Molecular Embryology and Genetics IMEG, Kumamoto University School of Medicine, Japan
Development 124:101-11. 1997..In the more lateral region of telencephalon, Emx2-deficiency may be compensated for by Emx1 and vice versa. Phenotypes of newborn brains also suggest that these genes function in neurogenesis corresponding to their later expressions...
- Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cellsHuansheng Xu
Institute of Biosciences and Technologies, Texas A and M University System, 2121 W Holcombe, Room 820C, TX, USA
Dev Biol 302:670-82. 2007..We conclude that the main functions of Tbx1 in the inner ear are to control, cell-autonomously, contribution, size and fate of a large population of otic epithelial cells, and, cell non-autonomously, cochlear morphogenesis...
- Disruption of Foxg1 expression by knock-in of cre recombinase: effects on the development of the mouse telencephalonK L Eagleson
Vanderbilt Kennedy Center for Research on Human Development and Department of Pharmacology, Vanderbilt University School of Medicine, 8110B Medical Research Building III, 465 21st Avenue South, Nashville, TN 37232, USA
Neuroscience 148:385-99. 2007..In order to delete genes specifically from the telencephalon, the Foxg1-cre line was created previously by replacing the intron-less Foxg1 coding region with cre, resulting in a Foxg1 ..