Foxg1

Summary

Gene Symbol: Foxg1
Description: forkhead box G1
Alias: 2900064B05Rik, BF-1, Bf1, Hfh9, Hfhbf1, HNF-3/forkhead homolog, brain factor 1, forkhead box protein G1, forkhead-related protein FKHL1
Species: mouse

Top Publications

  1. pmc The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear
    Amy E Kiernan
    The Jackson Laboratory, Bar Harbor, Maine, USA
    PLoS Genet 2:e4. 2006
  2. ncbi Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear
    Sarah Pauley
    Creighton University, Department of Biomedical Sciences, Omaha, Nebraska 68178, USA
    Dev Dyn 235:2470-82. 2006
  3. pmc Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3
    Vassiliki Fotaki
    Genes and Development Group, Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 26:9282-92. 2006
  4. ncbi Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1
    Nuria Flames
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 San Joan d Alacant, Spain
    Neuron 44:251-61. 2004
  5. pmc Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain
    Christopher A Fasano
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208 USA
    Genes Dev 23:561-74. 2009
  6. ncbi Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis
    Ben Martynoga
    Genes and Development Group, Biomedical Sciences, George Square, The University of Edinburgh, Edinburgh EH8 9XD, UK
    Dev Biol 283:113-27. 2005
  7. doi Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation
    Nicholas Warr
    Early Development, Mammalian Genetics Unit, MRC Harwell, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 17:2986-96. 2008
  8. doi Transcription factor Foxd1 is required for the specification of the temporal retina in mammals
    Maria Isabel Carreres
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas y Universidad Miguel Hernández, Campus San Juan de Alicante, 03550 Alicante, Spain
    J Neurosci 31:5673-81. 2011
  9. ncbi The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear
    Amy E Kiernan
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 132:4353-62. 2005
  10. ncbi Dorsal-ventral patterning defects in the eye of BF-1-deficient mice associated with a restricted loss of shh expression
    S Huh
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, 10021, USA
    Dev Biol 211:53-63. 1999

Scientific Experts

Detail Information

Publications110 found, 100 shown here

  1. pmc The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear
    Amy E Kiernan
    The Jackson Laboratory, Bar Harbor, Maine, USA
    PLoS Genet 2:e4. 2006
    ..These data demonstrate that JAG1-mediated Notch signaling is essential during early development for establishing the prosensory regions of the inner ear...
  2. ncbi Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear
    Sarah Pauley
    Creighton University, Department of Biomedical Sciences, Omaha, Nebraska 68178, USA
    Dev Dyn 235:2470-82. 2006
    ..Several Fox genes (Foxi1, Foxg1) are expressed in the developing otocyst of both zebrafish and mammals...
  3. pmc Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3
    Vassiliki Fotaki
    Genes and Development Group, Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 26:9282-92. 2006
    ..We observed occasional cells with diencephalic character in the Foxg1 (forkhead box)-expressing Gli3(Xt/Xt) telencephalon at embryonic day 10...
  4. ncbi Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1
    Nuria Flames
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 San Joan d Alacant, Spain
    Neuron 44:251-61. 2004
    ..These observations provide evidence that Neuregulin-1 and its ErbB4 receptor directly control neuronal migration in the nervous system...
  5. pmc Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain
    Christopher A Fasano
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208 USA
    Genes Dev 23:561-74. 2009
    ..We show that forebrain NSCs require the forebrain-specific transcription factor Foxg1 for Bmi-1-dependent self-renewal, and that repression of p21 is a focus of this interaction...
  6. ncbi Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis
    Ben Martynoga
    Genes and Development Group, Biomedical Sciences, George Square, The University of Edinburgh, Edinburgh EH8 9XD, UK
    Dev Biol 283:113-27. 2005
    Null mutation of the Foxg1 gene causes hypoplasia of the mouse telencephalon and loss of ventral telencephalic structures. We show that a crucial early requirement for Foxg1 is in the induction of ventral cell fate in the telencephalon...
  7. doi Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation
    Nicholas Warr
    Early Development, Mammalian Genetics Unit, MRC Harwell, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 17:2986-96. 2008
    ..The analysis provides genetic evidence that Zic2 functions during organizer formation and that the PCP develops via a multi-step process...
  8. doi Transcription factor Foxd1 is required for the specification of the temporal retina in mammals
    Maria Isabel Carreres
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas y Universidad Miguel Hernández, Campus San Juan de Alicante, 03550 Alicante, Spain
    J Neurosci 31:5673-81. 2011
    ..Overall, these results indicate that Foxd1 functions as a conserved determinant of temporal identity but reveal that the downstream effectors, and likely their mechanisms of action, are different in mammals and birds...
  9. ncbi The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear
    Amy E Kiernan
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 132:4353-62. 2005
    ..Our results demonstrate that the Notch pathway plays a dual role in regulating cellular differentiation and patterning in the cochlea, acting both through lateral inhibition and the control of cellular proliferation...
  10. ncbi Dorsal-ventral patterning defects in the eye of BF-1-deficient mice associated with a restricted loss of shh expression
    S Huh
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, 10021, USA
    Dev Biol 211:53-63. 1999
    ..This localized deficit in shh expression may also contribute to the prominence of the ventral defects in the telencephalon of the BF-1(-/-) mutant...
  11. pmc The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure
    Jinzhe Mao
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    Development 137:3079-88. 2010
    ..Finally, we demonstrate that this loss of forebrain maintenance is due in part to the iron deficiency that results from the absence of fully functional Fpn1...
  12. ncbi Foxd1 is required for proper formation of the optic chiasm
    Eloisa Herrera
    Departments of Pathology, Anatomy and Cell Biology and Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Development 131:5727-39. 2004
    ..retina, proteins designating the ipsilateral projection, such as Zic2 and EphB1, are missing, and the domain of Foxg1 (BF-1) expands from nasal retina into the VT crescent...
  13. ncbi Expression of winged helix genes, BF-1 and BF-2, define adjacent domains within the developing forebrain and retina
    V Hatini
    Cell Biology and Genetics Program, Sloan Kettering Division, Cornell University Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    J Neurobiol 25:1293-309. 1994
    ..These observations suggest that in addition to playing a role in the subdivision of the forebrain, these two WH factors may also function to establish positional information in the retinal neuroepithelium...
  14. doi Foxg1 regulates retinal axon pathfinding by repressing an ipsilateral program in nasal retina and by causing optic chiasm cells to exert a net axonal growth-promoting activity
    Natasha M Tian
    Centre for Integrative Physiology, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Development 135:4081-9. 2008
    ..We investigate how development of these patterns of projection is regulated by the contralateral determinant Foxg1, a forkhead box transcription factor expressed in nasal retina and at the chiasm...
  15. ncbi The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation
    J P Martinez Barbera
    Division of Mammalian Development, National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
    Development 127:2433-45. 2000
    ..All together, these results demonstrate that Hex function is essential in definitive endoderm for normal development of the forebrain, liver and thyroid gland...
  16. ncbi Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer
    Bente Madsen
    Breast Cancer Biology Group, Cancer Research UK, Guy s Hospital, St Thomas Street, London SE1 9RT, UK
    Mech Dev 119:S239-46. 2002
    ..Thus Plu-1 appears to play an important role in mouse embryonic development which may involve interaction with Pax9 and Bf-1...
  17. pmc The transcription factor Foxg1 regulates the competence of telencephalic cells to adopt subpallial fates in mice
    Martine Manuel
    Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Development 137:487-97. 2010
    b>Foxg1 is required for development of the ventral telencephalon in the embryonic mammalian forebrain...
  18. ncbi Inductive interactions direct early regionalization of the mouse forebrain
    K Shimamura
    Department of Psychiatry and Langley Porter Psychiatric Institute, University of California at San Francisco, 94143 0984, USA
    Development 124:2709-18. 1997
    ..The anterior neural ridge is essential for expression of BF1, a gene encoding a transcription factor required for regionalization and growth of the telencephalic and optic ..
  19. ncbi Hmx2 homeobox gene control of murine vestibular morphogenesis
    W Wang
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Development 128:5017-29. 2001
    ....
  20. ncbi Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers
    Elaine E Storm
    Department of Anatomy, University of California, San Francisco, CA 94143 2711, USA
    Development 133:1831-44. 2006
    ..We provide evidence that the hypoplasia results from decreased Foxg1 expression, reduced cell proliferation and increased cell death...
  21. ncbi Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles
    Y Ohkubo
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California, San Francisco, 401 Parnassus, P O Box 0984, San Francisco, CA 94143 0984, USA
    Neuroscience 111:1-17. 2002
    ....
  22. ncbi The role of Pax2 in mouse inner ear development
    Quianna Burton
    National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA
    Dev Biol 272:161-75. 2004
    ....
  23. ncbi Foxg1 suppresses early cortical cell fate
    Carina Hanashima
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Science 303:56-9. 2004
    ..of the earliest born neurons, the Cajal-Retzius cells, is suppressed by the telencephalic transcription factor Foxg1. In Foxg1 null mutants, we observed an excess of Cajal-Retzius neuron production in the cortex...
  24. ncbi FGF signalling generates ventral telencephalic cells independently of SHH
    Grigoriy Gutin
    Departments of Neuroscience and Molecular Genetics, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Development 133:2937-46. 2006
    ..Moreover, the Fgfr1;Fgfr2 phenotype, unlike the Shh phenotype, is not rescued by loss of Gli3, further indicating that FGFs act downstream of Shh and Gli3 to generate ventral telencephalic cell types...
  25. ncbi Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear
    Rachael Brooker
    Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 133:1277-86. 2006
    ..Our findings confirm that Notch signalling in the ear has distinct prosensory and lateral-inhibitory functions, for which different ligands are primarily responsible...
  26. pmc The transcription factor Foxg1 regulates telencephalic progenitor proliferation cell autonomously, in part by controlling Pax6 expression levels
    Martine N Manuel
    Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Neural Dev 6:9. 2011
    The transcription factor Foxg1 is an important regulator of telencephalic cell cycles...
  27. ncbi Human brain factor 1, a new member of the fork head gene family
    D B Murphy
    Institut fur Humangenetik, Gottingen, Germany
    Genomics 21:551-7. 1994
    ..HFK2 and HFK3 were found to be closely related but different from HFK1. Therefore, it would appear that HFK1, HFK2, HFK3, and BF-1 form a new fork head related subfamily...
  28. ncbi Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development
    Zhen Zhang
    Department of Pediatrics Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 132:5307-15. 2005
    ..We also thereby demonstrate conclusively that the role of Tbx1 in fourth PAA development is cell non-autonomous...
  29. ncbi Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo
    J Ding
    Center for Advanced Biotechnology and Medicine and Dept of Pediatrics, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Nature 395:702-7. 1998
    ..Our results indicate that Cripto signalling is essential for the conversion of a proximal-distal asymmetry into an orthogonal anterior-posterior axis...
  30. ncbi Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations
    Jelena S Arnold
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 133:977-87. 2006
    ..To assess the role of Tbx1 in the PE, a conditional allele of Tbx1 was generated using the Cre/loxP system. Foxg1-Cre was used to drive PE-specific ablation of Tbx1...
  31. ncbi Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment
    Chandrakala Puligilla
    Section on Developmental Neuroscience, NIDCD NIH, Bethesda, Maryland 20892, USA
    Dev Dyn 236:1905-17. 2007
    ....
  32. ncbi Domains of regulatory gene expression and the developing optic chiasm: correspondence with retinal axon paths and candidate signaling cells
    R C Marcus
    Department of Pathology, Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Comp Neurol 403:346-58. 1999
    ..Together, these data support the hypothesis that molecularly distinct, longitudinally aligned domains in the forebrain regulate the pattern of retinal axon projections in the developing hypothalamus...
  33. pmc Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation
    Guillermina López-Bendito
    Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
    Cell 125:127-42. 2006
    ..These results show that neuronal tangential migration constitutes a novel mechanism to control the timely arrangement of guidance cues required for axonal tract formation in the mammalian brain...
  34. doi Analysis of early ventral telencephalic defects in mice lacking functional Gli3 protein
    Tian Yu
    Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, Edinburgh, United Kingdom
    J Comp Neurol 512:613-27. 2009
    ..1, Mash1, and Foxg1 and its lack of expression of Pax6. We found that at embryonic day (E)10...
  35. doi Wnt/β-catenin signaling is disrupted in the extra-toes (Gli3(Xt/Xt) ) mutant from early stages of forebrain development, concomitant with anterior neural plate patterning defects
    Vassiliki Fotaki
    Genes and Development Group, Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Comp Neurol 519:1640-57. 2011
    ..Our data reveal that Gli3 is required at the neural plate stage to regulate Wnt expression and Wnt/β-catenin signaling in the presumptive forebrain and confirm its previously proposed role in patterning the anterior neural plate...
  36. ncbi Foxg1 confines Cajal-Retzius neuronogenesis and hippocampal morphogenesis to the dorsomedial pallium
    Luca Muzio
    Department of Biological and Technological Research, San Raffaele Scientific Institute, 20132 Milan, Italy
    J Neurosci 25:4435-41. 2005
    ..b>Foxg1, encoding for one of these factors, previously was reported to be necessary for basal ganglia morphogenesis, ..
  37. ncbi Notch 1 inhibits photoreceptor production in the developing mammalian retina
    Ashutosh P Jadhav
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 133:913-23. 2006
    ..These cone enriched mutant mice should prove to be a valuable resource for the study of this relatively rare mammalian photoreceptor cell type...
  38. ncbi Fibroblast growth factor receptor 1 is required for the proliferation of hippocampal progenitor cells and for hippocampal growth in mouse
    Yasushi Ohkubo
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 24:6057-69. 2004
    ..We conclude that Fgfr1 is necessary for hippocampal growth, because it promotes the proliferation of hippocampal progenitors and stem cells during development...
  39. ncbi Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain
    W Tao
    Division of Endocrinology, Memorial Sloan Kettering Cancer Center, New York, New York 10021
    Neuron 8:957-66. 1992
    ..These results suggest that BF-1 plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon...
  40. ncbi Development of midline cell types and commissural axon tracts requires Fgfr1 in the cerebrum
    Shubha Tole
    Department of Biological Sciences, Room B304, Tata Institute of Fundamental Research, Colaba, Mumbai, India
    Dev Biol 289:141-51. 2006
    ....
  41. pmc Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation
    Nathalie Marcal
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 25:10916-29. 2005
    ..In particular, Gro/TLE1 interacts with forkhead transcription factor brain factor 1 (BF-1; also termed FoxG1)...
  42. ncbi Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects
    M Ishibashi
    Institute for Immunology, Kyoto University Faculty of Medicine, Japan
    Genes Dev 9:3136-48. 1995
    ..These results suggest that HES-1 normally controls the proper timing of neurogenesis and regulates neural tube morphogenesis...
  43. ncbi Disrupted development of the cerebral hemispheres in transgenic mice expressing the mammalian Groucho homologue transducin-like-enhancer of split 1 in postmitotic neurons
    J Yao
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Canada
    Mech Dev 93:105-15. 2000
    ..These results provide the first direct evidence that TLE1 is an important negative regulator of postmitotic neuronal differentiation in the mammalian central nervous system...
  44. ncbi Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures
    J M Hebert
    Department of Biological Sciences, Stanford University, Stanford, California, 94305 5020, USA
    Dev Biol 222:296-306. 2000
    ..A mouse line was produced in which cre was targeted to the Foxg1 (BF-1) locus, a gene expressed specifically in the telencephalon and discrete head structures...
  45. pmc BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners
    C Dou
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 20:6201-11. 2000
    The winged-helix (WH) BF-1 gene, which encodes brain factor 1 (BF-1) (also known as foxg1), is essential for the proliferation of the progenitor cells of the cerebral cortex...
  46. pmc The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription
    J Yao
    Center for Neuronal Survival, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    Mol Cell Biol 21:1962-72. 2001
    ....
  47. ncbi Brain factor-1 controls the proliferation and differentiation of neocortical progenitor cells through independent mechanisms
    Carina Hanashima
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Neurosci 22:6526-36. 2002
    The winged helix gene Brain factor-1 (BF1) has a pleiotropic role in the development of the cerebral hemispheres of the brain. Mice lacking BF1 have defects in the morphogenesis of the structures of the dorsal telencephalon (e.g...
  48. ncbi FGFR1 is required for the development of the auditory sensory epithelium
    Ulla Pirvola
    Institute of Biotechnology, 00014 University of Helsinki, Helsinki, Finland
    Neuron 35:671-80. 2002
    ..Full inactivation of Fgfr1 in the inner ear epithelium by Foxg1-Cre-mediated deletion leads to an 85% reduction in the number of auditory hair cells...
  49. ncbi Dual role of brain factor-1 in regulating growth and patterning of the cerebral hemispheres
    C L Dou
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cereb Cortex 9:543-50. 1999
    ..These results raise the possibility that BF-1 may modulate both progenitor cell proliferation and regional patterning by regulating the expression or activity of inductive signals which act on the telencephalic neuroepithelium...
  50. ncbi Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres
    S Xuan
    Cell Biology and Genetics Program, Cornell University Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Neuron 14:1141-52. 1995
    ..These results suggest that BF-1 controls the morphogenesis of the telencephalon by regulating the rate of neuroepithelial cell proliferation and the timing of neuronal differentiation...
  51. ncbi FGF signaling through FGFR1 is required for olfactory bulb morphogenesis
    Jean M Hebert
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Development 130:1101-11. 2003
    ..Together the results demonstrate an essential role for Fgfr1 in patterning and morphogenesis of the telencephalon...
  52. ncbi The neural progenitor-specifying activity of FoxG1 is antagonistically regulated by CKI and FGF
    Tarik Regad
    The Wellcome Trust Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge, CB2 1QR, UK
    Nat Cell Biol 9:531-40. 2007
    b>FoxG1 is an evolutionarily conserved, winged-helix transcriptional repressor that maintains progenitor cells in the vertebrate forebrain. How the activity of FoxG1 is regulated is not known...
  53. ncbi The winged helix transcription factor Foxg1 facilitates retinal ganglion cell axon crossing of the ventral midline in the mouse
    Thomas Pratt
    Genes and Development Group, Biomedical Sciences, George Square, The University of Edinburgh, Edinburgh EH8 9XD, UK
    Development 131:3773-84. 2004
    ..The transcription factor Foxg1 (also known as BF1) is expressed at several key locations along this pathway...
  54. pmc Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage
    Nicole Arbour
    Department of Biochemistry, Microbiology, and Immunology, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5
    J Neurosci 28:6068-78. 2008
    ..Together, our results are the first to demonstrate the requirement of Mcl-1, an anti-apoptotic Bcl-2 family protein, for cortical neurogenesis and the survival of neurons after DNA damage...
  55. ncbi Hmx2 and Hmx3 homeobox genes direct development of the murine inner ear and hypothalamus and can be functionally replaced by Drosophila Hmx
    Weidong Wang
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Cell 7:439-53. 2004
    ....
  56. ncbi The role of Foxg1 and dorsal midline signaling in the generation of Cajal-Retzius subtypes
    Carina Hanashima
    Smilow Neuroscience Program and Department of Cell Biology, Smilow Research Center, New York University, New York, New York 10016, USA
    J Neurosci 27:11103-11. 2007
    ..bone morphogenetic proteins (BMPs) and Wnt (wingless-type MMTV integration site family) expression but lacking in Foxg1 (forkhead box G1) is a major source of CR neurons...
  57. doi The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling
    Saikat Mukhopadhyay
    Department of Research Oncology, Genentech Inc, South San Francisco, CA 94080, USA
    Cell 152:210-23. 2013
    ..Conversely, Shh signaling directs Gpr161 to be internalized from cilia, preventing its activity. Thus, Gpr161 defines a morphogenetic pathway coupling protein kinase A activation to Shh signaling during neural tube development...
  58. ncbi Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development
    Y Furuta
    Howard Hughes Medical Institute, Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Development 124:2203-12. 1997
    ..Bmp co-expression overlaps that of Msx1 and Hfh4, and is complementary to that of Bf1. The domain of Bmp co-expression is also associated with limited growth of the neuroectoderm, as revealed by ..
  59. ncbi Anterior neural plate regionalization in cripto null mutant mouse embryos in the absence of node and primitive streak
    Giovanna L Liguori
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Via Guglielmo Marconi 12, 80125 Naples, Italy
    Dev Biol 264:537-49. 2003
    ..These results suggest that, in mouse embryos, the specification of the anterior neural identities can be maintained without an absolute requirement for the embryonic mesoderm and the node...
  60. pmc Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex
    Alessandro Sessa
    Molecular Neuropathology Laboratory, SCRI, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Neuron 60:56-69. 2008
    ..Together, these findings identify Tbr2 as a critical factor for the specification of IPCs during corticogenesis...
  61. ncbi CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse
    Masayuki Uehara
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, Osaka 565 0871, Japan
    Dev Biol 302:399-411. 2007
    ....
  62. pmc Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism
    Ezat Sajedi
    Neural Development Unit, Institute of Child Health, University College London, London, UK
    Dis Model Mech 1:241-54. 2008
    ..Together, these results suggest that the I26T mutation yields a hypomorphic allele, whereas R160C produces a null allele and, consequently, a more severe phenotype in both mice and humans...
  63. pmc The small GTPase Rac1 regulates auditory hair cell morphogenesis
    Cynthia M Grimsley-Myers
    Department of Cell Biology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Neurosci 29:15859-69. 2009
    ..Together, these results reveal a critical function of Rac1 in morphogenesis of the auditory sensory epithelium and stereociliary bundle...
  64. ncbi Glypicans are differentially expressed during patterning and neurogenesis of early mouse brain
    Guillaume Luxardi
    IBDML CNRS UMR 6216, INSERM UMR623, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Biochem Biophys Res Commun 352:55-60. 2007
    ..The novel expression sites of glypicans shown here contribute to the identification of signalling molecules involved in brain patterning...
  65. doi Foxg1 is required for proper separation and formation of sensory cristae during inner ear development
    Chan Ho Hwang
    Lab of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850, USA
    Dev Dyn 238:2725-34. 2009
    ..Here, we analyzed the inner ears of Foxg1(-/-) mouse mutants, which display vestibular defects that are in conflict with the above model...
  66. ncbi BMP signalling inhibits premature neural differentiation in the mouse embryo
    Aida Di-Gregorio
    Molecular Embryology Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK
    Development 134:3359-69. 2007
    ..Together, our results demonstrate that inhibition of BMP signalling has a central role during neural induction in mammals and suggest that FGFs do not act as neural inducers in the post-implantation mouse embryo...
  67. ncbi Ciliary proteins link basal body polarization to planar cell polarity regulation
    Chonnettia Jones
    Department of Cell Biology, Emory University School of Medicine, 615 Michael St, Atlanta, Georgia 30322, USA
    Nat Genet 40:69-77. 2008
    ..Thus, our data uncover a distinct requirement for ciliary genes in basal body positioning and morphological polarization during PCP regulation...
  68. pmc Targeted connexin26 ablation arrests postnatal development of the organ of Corti
    Yunfeng Wang
    Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
    Biochem Biophys Res Commun 385:33-7. 2009
    ..These results demonstrated that Cx26 plays essential roles in postnatal maturation and homoeostasis of the organ of Corti before the onset of hearing...
  69. ncbi Longitudinal organization of the anterior neural plate and neural tube
    K Shimamura
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco 94143 0984, USA
    Development 121:3923-33. 1995
    ....
  70. pmc Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development
    Joseph A Brzezinski
    University of Washington, Department of Biological Structure, Seattle, WA 98195, USA
    Development 137:619-29. 2010
    ..We conclude that Blimp1 regulates the decision between photoreceptor and bipolar cell fates in the Otx2(+) cell population during retinal development...
  71. ncbi Mesenchymal patterning by Hoxa2 requires blocking Fgf-dependent activation of Ptx1
    Nicoletta Bobola
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Development 130:3403-14. 2003
    ....
  72. pmc Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development
    Oleg V Lagutin
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Genes Dev 17:368-79. 2003
    ..Furthermore, these results support the hypothesis that a Wnt signal gradient specifies posterior fates in the anterior neural plate...
  73. pmc Sp8 is crucial for limb outgrowth and neuropore closure
    Sheila M Bell
    Division of Developmental Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 100:12195-200. 2003
    ..These observations indicate that Sp8 functions downstream of Wnt3, Fgf10, and Bmpr1a in the signaling cascade that mediates AER formation...
  74. pmc The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis
    Nathalie G Berube
    Molecular Medicine Programs, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    J Clin Invest 115:258-67. 2005
    ..Taken together, our results indicate that ATRX is a critical mediator of cell survival during early neuronal differentiation. Thus, increased neuronal loss may contribute to the severe mental retardation observed in human patients...
  75. doi FoxG1 promotes the survival of postmitotic neurons
    Somasish Ghosh Dastidar
    Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas 75080, USA
    J Neurosci 31:402-13. 2011
    The transcription factor FoxG1 regulates neurogenesis in the embryonic telencephalon as well as a number of other neurodevelopmental processes...
  76. ncbi BMP signaling is required locally to pattern the dorsal telencephalic midline
    Jean M Hebert
    Department of Biological Sciences, Stanford University, 385 Serra Mall, CA 94305, USA
    Neuron 35:1029-41. 2002
    ..Our data fail to support a more global, concentration-dependent role in specifying telencephalic cell fates...
  77. ncbi Paleocortex is specified in mice in which dorsal telencephalic patterning is severely disrupted
    Aditee Vyas
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    J Comp Neurol 466:545-53. 2003
    ..In contrast, when the ventral telencephalon is almost completely deleted, such as in the BF1-/- brain, paleocortical markers are undetectable...
  78. pmc Visualizing the distribution of synapses from individual neurons in the mouse brain
    Ling Li
    Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, California, United States of America
    PLoS ONE 5:e11503. 2010
    ..To understand how complex neural circuits function, it is crucial to precisely describe neuronal connectivity and the distributions of synapses to and from individual neurons...
  79. pmc FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a
    Lisa D Urness
    Department of Human Genetics, University of Utah, 15 N 2030 E, RM 2100, Salt Lake City, UT 84112 5330, USA
    Dev Biol 340:595-604. 2010
    ..Several genes in the down-regulated class, including Hmx3, Hmx2, Foxg1, Sox9, Has2, and Slc26a9 were validated by in situ hybridization...
  80. ncbi Loss of orphan nuclear receptor GCNF function disrupts forebrain development and the establishment of the isthmic organizer
    Arthur C K Chung
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Biol 293:13-24. 2006
    ..Increased cell death may contribute to the loss of midbrain structure in GCNF-/- embryos. These results indicate that GCNF is required for establishment of the isthmic organizer, thereby regulating the midbrain development...
  81. pmc Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain
    R W Stottmann
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 335:166-78. 2009
    ..Finally, we evaluate Wnt signaling but do not find evidence that this plays a role in causing the perturbed neurodevelopmental phenotype we describe...
  82. ncbi Characterization of the structure and function of the gene for transcription factor BF-1, an essential regulator of forebrain development
    H Li
    Molecular Biology Program, Sloan Kettering Division, Cornell University Graduate School of Medical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Brain Res Mol Brain Res 37:96-104. 1996
    ..Using these cells, we demonstrate that the genomic region between -3.7kb and -79 bp upstream of the P1 promoter contains cell-specific enhancer activity in transient transfection assays...
  83. doi ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain
    Kristin D Kernohan
    Department of Paediatrics, 800 Commissioners Road East, London, ON N6C 2V5, Canada
    Dev Cell 18:191-202. 2010
    ..We propose that ATRX, cohesin, and MeCP2 cooperate to silence a subset of imprinted genes in the postnatal mouse brain...
  84. pmc Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family
    D E Clevidence
    Department of Biochemistry M C 536, University of Illinois College of Medicine, Chicago 60612
    Proc Natl Acad Sci U S A 90:3948-52. 1993
    ..The HNF-3/fkh motif therefore comprises a large gene family of transcription factors that play a role in tissue-specific gene regulation and development...
  85. pmc FGF signaling is strictly required to maintain early telencephalic precursor cell survival
    Hunki Paek
    Departments of Neuroscience and Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Development 136:2457-65. 2009
    ..Together with previous gain-of-function studies showing induction of Foxg1 expression and mirror-image duplications of the cortex by exogenous FGF8, our loss-of-function results suggest ..
  86. pmc Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39
    Julie M Schultz
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA
    Am J Hum Genet 85:25-39. 2009
    ..Overexpression of HGF is associated with progressive degeneration of outer hair cells in the cochlea, whereas cochlear deletion of Hgf is associated with more general dysplasia...
  87. ncbi A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain
    S L Ang
    Institute de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Illkirch, C U de Strasbourg, France
    Development 122:243-52. 1996
    ....
  88. doi Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm
    Dario Acampora
    CEINGE Biotecnologie Avanzate, 80145 Naples, Italy
    Mech Dev 126:882-97. 2009
    ....
  89. doi Differential requirements for Fgf3 and Fgf8 during mouse forebrain development
    Thomas Theil
    Centres for Neuroscience Research and Integrative Physiology, University of Edinburgh, Edinburgh, Scotland
    Dev Dyn 237:3417-23. 2008
    ..Therefore unlike in zebrafish, Fgf3 is not required for mouse forebrain development whereas Fgf8 has a central role during this process...
  90. ncbi Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4
    Perry J Blackshear
    Office of Clinical Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Development 130:4539-52. 2003
    ..These findings may be relevant to human congenital hydrocephalus, a birth defect that affects approximately 0.6 per 1000 newborns...
  91. ncbi Temporal requirement for hedgehog signaling in ventral telencephalic patterning
    Marc Fuccillo
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Development 131:5031-40. 2004
    ..events, we directed the removal of hedgehog signaling within the brain by embryonic day 9 of development, using a FoxG1(Cre) driver line to mediate the removal of a conditional smoothened null allele...
  92. ncbi A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo
    Makoto Ishibashi
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 129:4807-19. 2002
    ....
  93. ncbi Goosecoid and cerberus-like do not interact during mouse embryogenesis
    Ana C Borges
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Int J Dev Biol 46:259-62. 2002
    ..In conclusion, the analysis carried out indicated that gsc does not compensate for cer-l loss-of-function and that these genes do not interact genetically...
  94. ncbi Emx2 directs the development of diencephalon in cooperation with Otx2
    Y Suda
    Department of Morphogenesis, Institute of Molecular Embryology and Genetics IMEG, Kumamoto University, Japan
    Development 128:2433-50. 2001
    ..Consequently, development of the dorsal and ventral thalamus and anterior pretectum requires cooperation between Emx2 and Otx2, whereas Emx2 expression is incompatible with development of the commissural region of the pretectum...
  95. pmc Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients
    Jelena S Arnold
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Hum Mol Genet 15:1629-39. 2006
    ..first pharyngeal pouch (PPI) in forming outer and middle ears, we tissue-specifically inactivated the gene using Foxg1-Cre. In the conditional mutants, PPI failed to outgrow, preventing the middle ear bone condensations from forming...
  96. pmc BMP4 is essential for lens induction in the mouse embryo
    Y Furuta
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175 USA
    Genes Dev 12:3764-75. 1998
    ..Based on these results we propose that BMP4 is required for the optic vesicle to manifest its lens-inducing activity, by regulating downstream genes and/or serving as one component of multiple inductive signals...
  97. ncbi Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, Italy
    Development 125:5091-104. 1998
    ..Moreover, our data lead us to hypothesize that the differential post-transcriptional control existing between VE and epiblast cells may potentially contribute to fundamental regulatory mechanisms required for head specification...
  98. ncbi Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea
    Bonnie E Jacques
    Section on Developmental Neuroscience, Porter Neuroscience Research Center, 35 Convent Dr, Room 2A 100, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA
    Development 134:3021-9. 2007
    ..These results suggest that PCs might exist in a transient state of differentiation that makes them potential targets for regenerative therapies...
  99. pmc The mouse ADP-ribosylation factor-like 4 gene: two separate promoters direct specific transcription in tissues and testicular germ cell
    S Jacobs
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät der Rheinisch Westfälischen Technischen Hochschule Aachen, Wendlingweg 2, D 52057 Aachen, Germany
    Biochem J 335:259-65. 1998
    ..Chem. 269, 15683-15688]. The Arl4 gene maps to the proximal region of mouse chromosome 12 linked to Lamb1-1, Hfhbf1 and Sos2...
  100. pmc Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epithelium
    Steve Rodriguez
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Dev Biol 314:40-58. 2008
    ....
  101. doi Sox9 is required for invagination of the otic placode in mice
    Francisco Barrionuevo
    Institute of Human Genetics and Anthropology, University of Freiburg, Breisacherstr 33, D 79106 Freiburg, Germany
    Dev Biol 317:213-24. 2008
    ..We show that in mice with a Foxg1(Cre)-mediated conditional inactivation of Sox9 in the otic ectoderm, otic placodes form and express markers of ..