Gene Symbol: Foxd1
Description: forkhead box D1
Alias: AI385632, BF-2, FREAC4, Hfh10, Hfhbf2, forkhead box protein D1, FORKHEAD BOX PROTEIN D1 (FORKHEAD-RELATED PROTEIN FKHL8) (FORKHEAD-RELATED TRANSCRIPTION FACTOR 4) (FREAC-4), FREAC-4, HFH-BF-2, HNF-3/forkhead homolog, brain factor 2, brain factor 2, forkhead-related protein FKHL8, forkhead-related transcription factor 4
Species: mouse
Products:     Foxd1

Top Publications

  1. Levinson R, Batourina E, Choi C, Vorontchikhina M, Kitajewski J, Mendelsohn C. Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development. Development. 2005;132:529-39 pubmed
    ..Genetic deletion of the forkhead transcription factor, Foxd1, results in striking renal abnormalities, including the loss of these discrete zones and pelvic fused kidneys...
  2. Lin E, Sequeira Lopez M, Gomez R. RBP-J in FOXD1+ renal stromal progenitors is crucial for the proper development and assembly of the kidney vasculature and glomerular mesangial cells. Am J Physiol Renal Physiol. 2014;306:F249-58 pubmed publisher
    ..Deletion of RBP-J in renal stromal cells of the forkhead box D1 (FOXD1) lineage, which differentiate into all the mural cells of the kidney arterioles along with mesangial cells and ..
  3. Boyle S, Liu Z, Kopan R. Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development. Development. 2014;141:346-54 pubmed publisher
    ..Deletion of RBPjk, the common DNA-binding partner of all active Notch receptors, with Foxd1(tgCre) results in glomerular aneurysm and perinatal death from kidney failure...
  4. Schnabel C, Godin R, Cleary M. Pbx1 regulates nephrogenesis and ureteric branching in the developing kidney. Dev Biol. 2003;254:262-76 pubmed
    ..Taken together, these data establish a role for Pbx1 in mesenchymal-epithelial signaling and demonstrate that Pbx1 is an essential regulator of mesenchymal function during renal morphogenesis. ..
  5. Humphreys B, Lin S, Kobayashi A, Hudson T, Nowlin B, Bonventre J, et al. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol. 2010;176:85-97 pubmed publisher
    ..Lineage analysis shows that during nephrogenesis, FoxD1-positive((+)) mesenchymal cells give rise to adult CD73(+), platelet derived growth factor receptor beta(+), ..
  6. Self M, Lagutin O, Bowling B, Hendrix J, Cai Y, Dressler G, et al. Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J. 2006;25:5214-28 pubmed
    ..We propose that in the developing kidney, Six2 activity is required for maintaining the mesenchymal progenitor population in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud...
  7. Hatini V, Huh S, Herzlinger D, Soares V, Lai E. Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2. Genes Dev. 1996;10:1467-78 pubmed
  8. Fetting J, Guay J, Karolak M, Iozzo R, Adams D, Maridas D, et al. FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney. Development. 2014;141:17-27 pubmed publisher
    ..Forkhead transcription factors are essential for diverse processes in early embryonic development and organogenesis. Foxd1 is required during kidney development and its inactivation results in failure of nephron progenitor cell ..
  9. Bohnenpoll T, Bettenhausen E, Weiss A, Foik A, Trowe M, Blank P, et al. Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate. Dev Biol. 2013;380:25-36 pubmed publisher
    ..Our study provides new insights into the molecular diversity of urogenital progenitor cells and helps to understand the specification of the ureteric mesenchymal sub-lineage...

More Information


  1. Humphreys B, Valerius M, Kobayashi A, Mugford J, Soeung S, Duffield J, et al. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell. 2008;2:284-91 pubmed publisher
    ..These results indicate that regeneration by surviving tubular epithelial cells is the predominant mechanism of repair after ischemic tubular injury in the adult mammalian kidney. ..
  2. Quaggin S, Schwartz L, Cui S, Igarashi P, Deimling J, Post M, et al. The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis. Development. 1999;126:5771-83 pubmed
    ..Defects specific to later specialized cell types where Pod1 is expressed, such as the podocytes, were also observed, suggesting that this transcription factor may play multiple roles in kidney morphogenesis. ..
  3. Herrera E, Marcus R, Li S, Williams S, Erskine L, Lai E, et al. Foxd1 is required for proper formation of the optic chiasm. Development. 2004;131:5727-39 pubmed
    ..The winged helix transcription factor Foxd1 (previously known as BF-2, Brain Factor 2) is expressed in VT retina, as well as in the ventral diencephalon during the formation of the optic chiasm...
  4. Little M, Brennan J, Georgas K, Davies J, Davidson D, Baldock R, et al. A high-resolution anatomical ontology of the developing murine genitourinary tract. Gene Expr Patterns. 2007;7:680-99 pubmed
    ..Visual examples of how terms appear in different specimen types are also provided...
  5. Mendelsohn C, Batourina E, Fung S, Gilbert T, Dodd J. Stromal cells mediate retinoid-dependent functions essential for renal development. Development. 1999;126:1139-48 pubmed
    ..Since c-ret signaling is required for ureteric bud morphogenesis, loss of c-ret expression is a likely cause of impaired ureteric bud branching in RARalpha beta2(-) mutants. ..
  6. Yallowitz A, Hrycaj S, Short K, Smyth I, Wellik D. Hox10 genes function in kidney development in the differentiation and integration of the cortical stroma. PLoS ONE. 2011;6:e23410 pubmed publisher
    ..Careful examination of control kidneys show that Foxd1-expressing stromal precursor cells are first observed in a cap-like pattern anterior to the metanephric mesenchyme ..
  7. Mugford J, Sipila P, McMahon J, McMahon A. Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney. Dev Biol. 2008;324:88-98 pubmed publisher
    ..These studies provide new insights into the cellular origins of metanephric kidney structures and lend support to a model where Osr1 function is limited to establishing the nephron progenitor pool. ..
  8. Blank U, Brown A, Adams D, Karolak M, Oxburgh L. BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism. Development. 2009;136:3557-66 pubmed publisher
    ..Activation of Jun and ATF2 is severely diminished in Bmp7-null kidneys, providing an important in vivo correlate. BMP7 thus promotes proliferation directly in nephron progenitors by activating the JNK signaling circuitry. ..
  9. Pan Y, Woodbury A, Esko J, Grobe K, Zhang X. Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development. Development. 2006;133:4933-44 pubmed
    ..Taken together, these results establish an important role of Ndst1 function in FGF signaling during lens development. ..
  10. Hatini V, Tao W, Lai E. Expression of winged helix genes, BF-1 and BF-2, define adjacent domains within the developing forebrain and retina. J Neurobiol. 1994;25:1293-309 pubmed
    ..These observations suggest that in addition to playing a role in the subdivision of the forebrain, these two WH factors may also function to establish positional information in the retinal neuroepithelium. ..
  11. Paek H, Gutin G, Hebert J. FGF signaling is strictly required to maintain early telencephalic precursor cell survival. Development. 2009;136:2457-65 pubmed publisher
  12. Marcos S, González Lázaro M, Beccari L, Carramolino L, Martín Bermejo M, Amarie O, et al. Meis1 coordinates a network of genes implicated in eye development and microphthalmia. Development. 2015;142:3009-20 pubmed publisher
    ..We propose that Meis1 is at the core of a genetic network implicated in eye patterning/microphthalmia, and represents an additional candidate for syndromic cases of these ocular malformations. ..
  13. Hurtado R, Zewdu R, Mtui J, Liang C, Aho R, Kurylo C, et al. Pbx1-dependent control of VMC differentiation kinetics underlies gross renal vascular patterning. Development. 2015;142:2653-64 pubmed publisher
    ..These findings identify, for the first time, an in vivo transcriptional regulator of PDGFRβ, and reveal a previously unappreciated role for VMCs in systems-level vascular patterning. ..
  14. Patterson L, Pembaur M, Potter S. Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney. Development. 2001;128:2153-61 pubmed
  15. Lin Y, Liu A, Zhang S, Ruusunen T, Kreidberg J, Peltoketo H, et al. Induction of ureter branching as a response to Wnt-2b signaling during early kidney organogenesis. Dev Dyn. 2001;222:26-39 pubmed
    ..In addition, Wnt signals in the kidney differ qualitatively and are specific to either the epithelial ureteric bud or the kidney mesenchyme. ..
  16. Kobayashi H, Liu Q, Binns T, Urrutia A, Davidoff O, Kapitsinou P, et al. Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin. J Clin Invest. 2016;126:1926-38 pubmed publisher
    ..Here we targeted the PHD/HIF-2/EPO axis in FOXD1 stroma-derived renal interstitial cells and examined the role of individual PHDs in REPC pool size regulation and ..
  17. Boivin F, Sarin S, Lim J, Javidan A, Svajger B, Khalili H, et al. Stromally expressed β-catenin modulates Wnt9b signaling in the ureteric epithelium. PLoS ONE. 2015;10:e0120347 pubmed publisher
    ..We propose that β-catenin in the renal stroma modulates a genetic program in ureteric epithelium that is required for the induction of nephron progenitors. ..
  18. Nagy I, Xu Q, Naillat F, Ali N, Miinalainen I, Samoylenko A, et al. Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis. BMC Dev Biol. 2016;16:30 pubmed publisher
    ..of Wnt11 signaling reduced the expression of several genes implicated in kidney development, such as Wnt9b, Six2, Foxd1 and Hox10...
  19. Lin L, Peng S. Coordination of NF-kappaB and NFAT antagonism by the forkhead transcription factor Foxd1. J Immunol. 2006;176:4793-803 pubmed
    ..interactions between the forkhead family members and inflammatory transcription factors: the forkhead member Foxd1 coordinates the regulation of the activity of two key inflammatory transcription factors, NF-AT and NF-kappaB, ..
  20. Gumbel J, Patterson E, Owusu S, Kabat B, Jung D, Simmons J, et al. The forkhead transcription factor, Foxd1, is necessary for pituitary luteinizing hormone expression in mice. PLoS ONE. 2012;7:e52156 pubmed publisher
    ..The studies described in this report reveal that the forkhead transcription factor, Foxd1, is not expressed in the developing mouse pituitary gland, but rather in the mesenchyme surrounding the pituitary ..
  21. Sims Lucas S, Cullen McEwen L, Eswarakumar V, Hains D, Kish K, Becknell B, et al. Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia. Am J Physiol Renal Physiol. 2009;297:F1208-19 pubmed publisher
    ..Furthermore, Frs2alpha may transmit signals through other receptor kinases present in ureteric epithelium. Finally, the renal hypoplasia observed in Frs2alpha(UB-/-) mice is likely secondary to decreased Ret and Wnt11 expression. ..
  22. Mariani F, Harland R. XBF-2 is a transcriptional repressor that converts ectoderm into neural tissue. Development. 1998;125:5019-31 pubmed
    We have identified Xenopus Brain Factor 2 (XBF-2) as a potent neuralizing activity in an expression cloning screen. In ectodermal explants, XBF-2 converts cells from an epidermal to a neural fate...
  23. Furuta Y, Hogan B. BMP4 is essential for lens induction in the mouse embryo. Genes Dev. 1998;12:3764-75 pubmed
    ..Based on these results we propose that BMP4 is required for the optic vesicle to manifest its lens-inducing activity, by regulating downstream genes and/or serving as one component of multiple inductive signals. ..
  24. Koga M, Matsuda M, Kawamura T, Sogo T, Shigeno A, Nishida E, et al. Foxd1 is a mediator and indicator of the cell reprogramming process. Nat Commun. 2014;5:3197 pubmed publisher
    ..Here we identify two forkhead box transcription factors, Foxd1 and Foxo1, as mediators of gene expression programme changes during reprogramming...
  25. Labosky P, Winnier G, Jetton T, Hargett L, Ryan A, Rosenfeld M, et al. The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex. Development. 1997;124:1263-74 pubmed
    ..These results provide evidence that Mf3 is required for normal hypothalamus development and suggest that Mf3 may play a role in postnatal growth and lactation. ..
  26. Tian N, Pratt T, Price D. Foxg1 regulates retinal axon pathfinding by repressing an ipsilateral program in nasal retina and by causing optic chiasm cells to exert a net axonal growth-promoting activity. Development. 2008;135:4081-9 pubmed publisher
    ..numbers of ipsilateral projections and ectopic expression of the ipsilateral determinants Zic2, Ephb1 and Foxd1, indicating that nasal retina is competent to express an ipsilateral program that is normally suppressed by Foxg1...
  27. Kan L, Peng C, McGuire T, Kessler J. Glast-expressing progenitor cells contribute to heterotopic ossification. Bone. 2013;53:194-203 pubmed publisher
    ..utilized Cre-lox based genetic lineage tracing to examine the contribution to HO of cells that expressed either FoxD1 or Glast...
  28. Chi L, Zhang S, Lin Y, Prunskaite Hyyryläinen R, Vuolteenaho R, Itäranta P, et al. Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development. Development. 2004;131:3345-56 pubmed
    ..Together, these data suggest that Spry genes contribute to reciprocal epithelial-mesenchymal and stromal signalling controlling ureteric branching, which involves the coordination of Ffg/Wnt11/Gdnf pathways. ..
  29. Dahle M, Grønning L, Cederberg A, Blomhoff H, Miura N, Enerback S, et al. Mechanisms of FOXC2- and FOXD1-mediated regulation of the RI alpha subunit of cAMP-dependent protein kinase include release of transcriptional repression and activation by protein kinase B alpha and cAMP. J Biol Chem. 2002;277:22902-8 pubmed
    ..and Enerbäck, S. (2001) Cell 106, 563-573). In this present study, we reveal that FOXC2 and a related factor, FOXD1, specifically activate the 1b promoter of the RI alpha gene in adipocytes and testicular Sertoli cells, ..
  30. Batourina E, Gim S, Bello N, Shy M, Clagett Dame M, Srinivas S, et al. Vitamin A controls epithelial/mesenchymal interactions through Ret expression. Nat Genet. 2001;27:74-8 pubmed
    ..In the first part of the loop, vitamin-A-dependent signals secreted by stromal cells control Ret expression in the ureteric bud. In the second part of the loop, ureteric bud signals dependent on Ret control stromal cell patterning. ..
  31. Perälä N, Jakobson M, Ola R, Fazzari P, Penachioni J, Nymark M, et al. Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney. Differentiation. 2011;81:81-91 pubmed publisher
  32. Boivin F, Sarin S, Dabas P, Karolak M, Oxburgh L, Bridgewater D. Stromal β-catenin overexpression contributes to the pathogenesis of renal dysplasia. J Pathol. 2016;239:174-85 pubmed publisher
    ..Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. ..
  33. Hung C, Linn G, Chow Y, Kobayashi A, Mittelsteadt K, Altemeier W, et al. Role of lung pericytes and resident fibroblasts in the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med. 2013;188:820-30 pubmed publisher
    ..We mapped the fate of Foxd1-expressing embryonic progenitors and their progeny during lung development, adult homeostasis, and after fibrosing ..
  34. Carreres M, Escalante A, Murillo B, Chauvin G, Gaspar P, Vegar C, et al. Transcription factor Foxd1 is required for the specification of the temporal retina in mammals. J Neurosci. 2011;31:5673-81 pubmed publisher
    ..Gain-of-function experiments in chick raised the hypothesis that the transcription factor Foxd1 specifies retinal temporal identity. However, it remains unknown whether Foxd1 is necessary for this function...
  35. Dou C, Li S, Lai E. Dual role of brain factor-1 in regulating growth and patterning of the cerebral hemispheres. Cereb Cortex. 1999;9:543-50 pubmed
    ..These results raise the possibility that BF-1 may modulate both progenitor cell proliferation and regional patterning by regulating the expression or activity of inductive signals which act on the telencephalic neuroepithelium. ..
  36. Tripathi P, Guo Q, Wang Y, Coussens M, Liapis H, Jain S, et al. Midline signaling regulates kidney positioning but not nephrogenesis through Shh. Dev Biol. 2010;340:518-27 pubmed publisher
    ..These studies also provide insights into the pathogenesis of horseshoe kidneys and how congenital kidney defects can be caused by signals outside the renal primordia. ..
  37. Boyle S, Kim M, Valerius M, McMahon A, Kopan R. Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells. Development. 2011;138:4245-54 pubmed publisher
    ..After MET, Notch provides an instructive signal directing cells towards the proximal tubule lineage at the expense of other renal epithelial fates. ..
  38. Chen S, Yao X, Li Y, Saifudeen Z, Bachvarov D, El Dahr S. Histone deacetylase 1 and 2 regulate Wnt and p53 pathways in the ureteric bud epithelium. Development. 2015;142:1180-92 pubmed publisher
    ..Together, these data indicate that Hdac1 and Hdac2 are crucial for kidney development. They perform redundant, yet essential, cell lineage-autonomous functions via p53-dependent and -independent pathways. ..
  39. Jeong J, Mao J, Tenzen T, Kottmann A, McMahon A. Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev. 2004;18:937-51 pubmed
    ..Further, our analysis of Shh-Fox gene regulatory interactions leads us to propose that Fox genes mediate the action of Shh in facial development. ..
  40. Cesario J, Landin Malt A, Deacon L, Sandberg M, Vogt D, Tang Z, et al. Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2. Hum Mol Genet. 2015;24:5024-39 pubmed publisher
    ..This is the first report elucidating a molecular genetic pathway downstream of Lhx in palate development. ..
  41. Kobayashi A, Mugford J, Krautzberger A, Naiman N, Liao J, McMahon A. Identification of a multipotent self-renewing stromal progenitor population during mammalian kidney organogenesis. Stem Cell Reports. 2014;3:650-62 pubmed publisher
    ..However, the cellular mechanisms establishing stromal tissues are less clear. We demonstrate that the Foxd1-expressing cortical stroma represents a distinct multipotent self-renewing progenitor population that gives rise ..
  42. Sánchez Arrones L, Nieto Lopez F, Sánchez Camacho C, Carreres M, Herrera E, Okada A, et al. Shh/Boc signaling is required for sustained generation of ipsilateral projecting ganglion cells in the mouse retina. J Neurosci. 2013;33:8596-607 pubmed publisher
    ..RGCs is reduced, whereas more Islet2/Shh-positive RGCs are observed, a phenotype also detected in Zic2 and Foxd1 null embryos...
  43. Salvatierra J, Lee D, Zibetti C, Duran Moreno M, Yoo S, Newman E, et al. The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation. J Neurosci. 2014;34:16809-20 pubmed publisher
    ..These findings provide key insights into the transcriptional regulatory network specifying this still poorly characterized cell type. ..
  44. Malhotra D, Linehan J, Dileepan T, Lee Y, Purtha W, Lu J, et al. Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns. Nat Immunol. 2016;17:187-95 pubmed publisher
    ..Thus, the immunotolerance of polyclonal CD4(+) T cells was maintained by distinct mechanisms, according to self-peptide expression patterns. ..
  45. Sequeira Lopez M, Nagalakshmi V, Li M, Sigmund C, Gomez R. Vascular versus tubular renin: role in kidney development. Am J Physiol Regul Integr Comp Physiol. 2015;309:R650-7 pubmed publisher
    ..we deleted renin independently in the vascular and tubular compartments by crossing Ren1(c fl/fl) mice to Foxd1-cre and Hoxb7-cre mice, respectively...
  46. de Graaff E, Srinivas S, Kilkenny C, D AGATI V, Mankoo B, Costantini F, et al. Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis. Genes Dev. 2001;15:2433-44 pubmed
    ..Our findings show that RET9 and RET51 have different signaling properties in vivo and define specific temporal and spatial requirements of c-Ret function during renal development and histogenesis of the enteric nervous system. ..
  47. Smith R, Huang Y, Tian T, Vojtasova D, Mesalles Naranjo O, Pollard S, et al. The Transcription Factor Foxg1 Promotes Optic Fissure Closure in the Mouse by Suppressing Wnt8b in the Nasal Optic Stalk. J Neurosci. 2017;37:7975-7993 pubmed publisher
    ..Our results unravel a new role of Foxg1 in promoting OF closure providing additional knowledge about the molecules and cellular mechanisms underlying coloboma formation. ..
  48. Hartman H, Lai H, Patterson L. Cessation of renal morphogenesis in mice. Dev Biol. 2007;310:379-87 pubmed
    ..These results suggest that the sequence of events leading to disruption of the cycle of branching morphogenesis and nephrogenesis began with the loss of mesenchyme that resulted from its conversion into nephrons. ..
  49. Schmidt Ott K, Chen X, Paragas N, Levinson R, Mendelsohn C, Barasch J. c-kit delineates a distinct domain of progenitors in the developing kidney. Dev Biol. 2006;299:238-49 pubmed the ureteric bud, c-kit-positive cells are located within the renal interstitium, but are negative for Foxd1, an established marker of stromal cells...
  50. Wainwright E, Wilhelm D, Combes A, Little M, Koopman P. ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation. Dev Biol. 2015;404:88-102 pubmed publisher
    ..These insights illuminate the aetiology of multiplex kidney formation in human individuals with ROBO2 mutations. ..
  51. Mao Y, Mulvaney J, Zakaria S, Yu T, Morgan K, Allen S, et al. Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development. 2011;138:947-57 pubmed publisher
    ..Our analysis implies that Dchs1 and Fat4 function as a ligand-receptor pair during murine development, and identifies novel requirements for Dchs1-Fat4 signaling in multiple organs. ..
  52. Marcus R, Shimamura K, Sretavan D, Lai E, Rubenstein J, Mason C. Domains of regulatory gene expression and the developing optic chiasm: correspondence with retinal axon paths and candidate signaling cells. J Comp Neurol. 1999;403:346-58 pubmed
    ..Together, these data support the hypothesis that molecularly distinct, longitudinally aligned domains in the forebrain regulate the pattern of retinal axon projections in the developing hypothalamus. ..
  53. Qiu L, Hyink D, Gans W, Amsler K, Wilson P, Burrow C. Midkine promotes selective expansion of the nephrogenic mesenchyme during kidney organogenesis. Organogenesis. 2004;1:14-21 pubmed
    ..These results suggest that Midkine may regulate the balance of epithelial and stromal progenitor cell populations of the metanephric mesenchyme during renal organogenesis. ..
  54. Leaf I, Nakagawa S, Johnson B, Cha J, Mittelsteadt K, Guckian K, et al. Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury. J Clin Invest. 2017;127:321-334 pubmed publisher
    ..Moreover, these findings suggest that disruption of this MyD88-dependent pathway in pericytes might be a potential therapeutic approach to inhibit fibrogenesis and promote regeneration. ..
  55. Airik R, Bussen M, Singh M, Petry M, Kispert A. Tbx18 regulates the development of the ureteral mesenchyme. J Clin Invest. 2006;116:663-74 pubmed
    ..Our analysis also showed that the ureteral mesenchyme derives from a distinct cell population that is separated early in kidney development from that of other mesenchymal cells of the renal system. ..
  56. Cui S, Schwartz L, Quaggin S. Pod1 is required in stromal cells for glomerulogenesis. Dev Dyn. 2003;226:512-22 pubmed
    ..Most strikingly, the glomerulogenesis defect was rescued by the presence of wild-type stromal cells, suggesting a non-cell autonomous role for Pod1 in this cell population. ..
  57. Wu S, Grindley J, Winnier G, Hargett L, Hogan B. Mouse Mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis. Mech Dev. 1998;70:3-13 pubmed
    ..These results suggest that Mf2, like other murine forkhead genes, has multiple roles in embryogenesis, possibly mediating the response of cells to signaling molecules such as SHH. ..
  58. Pierrou S, Hellqvist M, Samuelsson L, Enerback S, Carlsson P. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. EMBO J. 1994;13:5002-12 pubmed
    ..Applying a circular permutation assay, we show that binding of FREAC proteins to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. ..
  59. Laissue P, Lakhal B, Vatin M, Batista F, Burgio G, Mercier E, et al. Association of FOXD1 variants with adverse pregnancy outcomes in mice and humans. Open Biol. 2016;6: pubmed
    ..Bioinformatics approaches led us to select Foxd1 as a candidate gene potentially related to ER and RSA...
  60. Caubit X, Lye C, Martin E, Coré N, Long D, Vola C, et al. Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development. 2008;135:3301-10 pubmed publisher
  61. Yu J, Holland N, Holland L. An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution. Dev Dyn. 2002;225:289-97 pubmed
    ..Phylogenetic analysis indicates that the AmphiFoxD is basal to vertebrate FoxD1, FoxD2, FoxD3, FoxD4, and FoxD5...
  62. Baumer N, Marquardt T, Stoykova A, Ashery Padan R, Chowdhury K, Gruss P. Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle. Development. 2002;129:4535-45 pubmed
    ..We found that Pax6 activity is required for the establishment, as well as the maintenance of dorsal and nasotemporal characteristics in the optic vesicle and, later, the optic cup. ..
  63. Valerius M, Patterson L, Feng Y, Potter S. Hoxa 11 is upstream of Integrin alpha8 expression in the developing kidney. Proc Natl Acad Sci U S A. 2002;99:8090-5 pubmed
    ..This work suggests that the Integrin alpha8 gene may be a major effector of Hoxa 11/Hoxd 11 function in the developing kidney. ..
  64. Urbach A, Yermalovich A, Zhang J, Spina C, Zhu H, Perez Atayde A, et al. Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev. 2014;28:971-82 pubmed publisher
    ..Finally, we demonstrate overexpression of the LIN28B paralog in a significant percentage of human Wilms tumor. Our data thus implicate the Lin28/Let-7 pathway in kidney development and tumorigenesis...
  65. Paek H, Antoine M, Diaz F, Hebert J. Increased ?-catenin activity in the anterior neural plate induces ectopic mid-hindbrain characteristics. Dev Dyn. 2012;241:242-6 pubmed publisher
  66. Chang Y, Yang C, Pan S, Chou Y, Chang F, Lai C, et al. DNA methyltransferase inhibition restores erythropoietin production in fibrotic murine kidneys. J Clin Invest. 2016;126:721-31 pubmed publisher
    ..Here, we show that fibroblast-like FOXD1+ progenitor-derived kidney pericytes, which are characterized by the expression of α1 type I collagen and PDGFR..
  67. Zhang H, Palmer R, Gao X, Kreidberg J, Gerald W, Hsiao L, et al. Transcriptional activation of placental growth factor by the forkhead/winged helix transcription factor FoxD1. Curr Biol. 2003;13:1625-9 pubmed
    ..Expression of the forkhead/winged helix transcription factor FoxD1 (BF-2) is restricted to stromal cells in the embryonic renal cortex, but it mediates its effects on the adjacent ..
  68. Grindley J, Hargett L, Hill R, Ross A, Hogan B. Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon. Mech Dev. 1997;64:111-26 pubmed
    ..Thus, PAX6 is essential for the normal development and regionalization of the diencephalon. ..
  69. Li J, Cui Y, Xu J, Wang Q, Yang X, Li Y, et al. Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development. J Biol Chem. 2017;292:15814-15825 pubmed publisher
  70. Mao Y, Francis West P, Irvine K. Fat4/Dchs1 signaling between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching. Development. 2015;142:2574-85 pubmed publisher
  71. Grieshammer U, Cebrian C, Ilagan R, Meyers E, Herzlinger D, Martin G. FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons. Development. 2005;132:3847-57 pubmed
    ..Thus, unlike other FGF family members, which regulate growth and branching morphogenesis of the collecting duct system, Fgf8 encodes a factor essential for gene regulation and cell survival at distinct steps in nephrogenesis. ..
  72. Leimeister C, Schumacher N, Diez H, Gessler M. Cloning and expression analysis of the mouse stroma marker Snep encoding a novel nidogen domain protein. Dev Dyn. 2004;230:371-7 pubmed
    ..Furthermore, comparative expression analysis of kidney stroma markers suggests that Snep is expressed in a specific subpopulation of stromal cells and may provide environmental cues to support regular development. ..
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