Gene Symbol: Fosb
Description: FBJ osteosarcoma oncogene B
Alias: protein fosB, osteosarcoma oncoprotein B FosB
Species: mouse
Products:     Fosb

Top Publications

  1. Rosemann M, Lintrop M, Favor J, Atkinson M. Bone tumorigenesis induced by alpha-particle radiation: mapping of genetic loci influencing predisposition in mice. Radiat Res. 2002;157:426-34 pubmed
    ..This study demonstrates the presence of a genetic component that modulates predisposition to radiation-induced osteosarcoma. ..
  2. Kuroda K, Ornthanalai V, Kato T, Murphy N. FosB null mutant mice show enhanced methamphetamine neurotoxicity: potential involvement of FosB in intracellular feedback signaling and astroglial function. Neuropsychopharmacology. 2010;35:641-55 pubmed publisher
    Previous studies show that (1) two members of fos family transcription factors, c-Fos and FosB, are induced in frontal brain regions by methamphetamine; (2) null mutation of c-Fos exacerbates methamphetamine-induced neurotoxicity; and (3) ..
  3. Chen J, An B, Cheng L, Hammond G, Leung P. Gonadotropin-releasing hormone-mediated phosphorylation of estrogen receptor-alpha contributes to fosB expression in mouse gonadotrophs. Endocrinology. 2009;150:4583-93 pubmed publisher
    ..Most importantly, both GnRH subtypes robustly up-regulated expression of the immediate early response gene, fosB, whereas cotreatment with ERalpha siRNA or PCAF siRNA attenuated this effect...
  4. Freet C, Steffen C, Nestler E, Grigson P. Overexpression of DeltaFosB is associated with attenuated cocaine-induced suppression of saccharin intake in mice. Behav Neurosci. 2009;123:397-407 pubmed publisher
    ..It is hypothesized that elevation of DeltaFosB not only increases the reward value of drug, but the reward value of the saccharin cue as well. ..
  5. Ezhkova E, Pasolli H, Parker J, Stokes N, Su I, Hannon G, et al. Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell. 2009;136:1122-35 pubmed publisher
    ..They maintain their proliferative potential and globally repressing undesirable differentiation programs while selectively establishing a specific terminal differentiation program in a stepwise fashion. ..
  6. Lazo P, Dorfman K, Noguchi T, Mattei M, Bravo R. Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promoter. Nucleic Acids Res. 1992;20:343-50 pubmed
    We have determined the genomic structure of the fosB gene and shown that it consists of 4 exons and 3 introns at positions also found in the c-fos gene...
  7. Giordano C, Vinet J, Curia G, Biagini G. Repeated 6-Hz Corneal Stimulation Progressively Increases FosB/ΔFosB Levels in the Lateral Amygdala and Induces Seizure Generalization to the Hippocampus. PLoS ONE. 2015;10:e0141221 pubmed publisher
    ..We propose that the repeated 6-Hz corneal stimulation model may be used to investigate some mechanisms of epileptogenesis and to test putative antiepileptogenic drugs. ..
  8. Phillips D, Choleris E, Ervin K, Fureix C, Harper L, Reynolds K, et al. Cage-induced stereotypic behaviour in laboratory mice covaries with nucleus accumbens FosB/ΔFosB expression. Behav Brain Res. 2016;301:238-42 pubmed publisher
    ..Here, we used immunohistochemical staining of FosB and ΔFosB to assess long-term activation within the nucleus accumbens and caudate-putamen of C57BL/6 mice...
  9. Gavala M, Hill L, Lenertz L, Karta M, Bertics P. Activation of the transcription factor FosB/activating protein-1 (AP-1) is a prominent downstream signal of the extracellular nucleotide receptor P2RX7 in monocytic and osteoblastic cells. J Biol Chem. 2010;285:34288-98 pubmed publisher
    ..P2RX7 agonists substantially induces the expression of several activating protein-1 (AP-1) members, particularly FosB. The potent activation of FosB after P2RX7 stimulation is especially noteworthy considering that little is known ..

More Information


  1. Hiroi N, Marek G, Brown J, Ye H, Saudou F, Vaidya V, et al. Essential role of the fosB gene in molecular, cellular, and behavioral actions of chronic electroconvulsive seizures. J Neurosci. 1998;18:6952-62 pubmed
    ..The upregulation of NMDAR1 was absent in mice with a targeted disruption of the fosB gene...
  2. Korkosz A, Kolomanska P, Kowalska K, Rogowski A, Radwanska K, Kaczmarek L, et al. Dissociation of ethanol and saccharin preference in fosB knockout mice. Physiol Behav. 2004;82:391-5 pubmed
    ..Among different genes coding Fos proteins is the fosB gene...
  3. Malik M, Jividen K, Padmakumar V, Cataisson C, Li L, Lee J, et al. Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation. Proc Natl Acad Sci U S A. 2012;109:6130-5 pubmed publisher
    ..In mice, genetically null for CLIC4, the number of phagocytosing macrophages stimulated by LPS is reduced. Thus, iNOS-induced nuclear CLIC4 is an essential part of the macrophage deactivation program. ..
  4. Sabatakos G, Sims N, Chen J, Aoki K, Kelz M, Amling M, et al. Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat Med. 2000;6:985-90 pubmed a potent AP-1-related regulator of osteoblast function: DeltaFosB, a naturally occurring truncated form of FosB that arises from alternative splicing of the fosB transcript and is expressed in osteoblasts...
  5. You J, Muralidharan K, Park J, Petrof I, Pyfer M, Corbett B, et al. Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits. Nat Med. 2017;23:1377-1383 pubmed publisher
    ..We demonstrate that ΔFosB, a highly stable transcription factor, is induced in the hippocampus in mouse models of AD and seizures, in which ..
  6. Zheng H, Yuan C, Bao L, An J, Zhu Z, Yang G. [Overexpression of the truncated fosb isoform (Delta2Deltafosb) increases nodus in CD1 primary osteoblastes]. Fen Zi Xi Bao Sheng Wu Xue Bao. 2008;41:222-6 pubmed
    The recombinant adenoviruses which can overexpress fosb and Delta2Deltafosb proteins were produced...
  7. Shiromani P, Basheer R, Thakkar J, Wagner D, Greco M, Charness M. Sleep and wakefulness in c-fos and fos B gene knockout mice. Brain Res Mol Brain Res. 2000;80:75-87 pubmed
    ..By demonstrating that these IEGs are involved in sleep, we suggest that the deletion of specific genes, even within a family of genes, can have a specific effect on sleep. ..
  8. Malik M, Peng Y, Kline D, Adhikary G, Prabhakar N. Impaired ventilatory acclimatization to hypoxia in mice lacking the immediate early gene fos B. Respir Physiol Neurobiol. 2005;145:23-31 pubmed
    ..These results suggest that the fos B, an immediate early gene, plays an important role in ventilatory acclimatization to hypoxia in mice. ..
  9. Kuroda K, Meaney M, Uetani N, Kato T. Neurobehavioral basis of the impaired nurturing in mice lacking the immediate early gene FosB. Brain Res. 2008;1211:57-71 pubmed publisher
    The transcription factor FosB is induced in neurons of the medial preoptic area (MPOA) during parenting, through activation of the extracellular signal-regulated kinase (ERK)...
  10. You J, Stephens G, Fu C, Zhang X, Liu Y, Chin J. Genome-wide profiling reveals functional diversification of ∆FosB gene targets in the hippocampus of an Alzheimer's disease mouse model. PLoS ONE. 2018;13:e0192508 pubmed publisher
    The activity-induced transcription factor ∆FosB has been implicated in Alzheimer's disease (AD) as a critical regulator of hippocampal function and cognition downstream of seizures and network hyperexcitability...
  11. Bard Chapeau E, Jeyakani J, Kok C, Müller J, Chua B, Gunaratne J, et al. Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors. Proc Natl Acad Sci U S A. 2012;109:2168-73 pubmed publisher
    ..Collectively, our data indicate that EVI1 is a multipurpose transcription factor that synergizes with FOS in invasive tumors. ..
  12. Grueter B, ROBISON A, Neve R, Nestler E, Malenka R. ?FosB differentially modulates nucleus accumbens direct and indirect pathway function. Proc Natl Acad Sci U S A. 2013;110:1923-8 pubmed publisher
    ..The transcription factor ?FosB is one of the key proteins implicated in the gene expression changes in NAc caused by drugs of abuse, yet its ..
  13. Buenrostro Jáuregui M, Ciudad Roberts A, Moreno J, Muñoz Villegas P, López Arnau R, Pubill D, et al. Changes in CREB and deltaFosB are associated with the behavioural sensitization induced by methylenedioxypyrovalerone. J Psychopharmacol. 2016;30:707-12 pubmed publisher
    ..We hypothesize that, similar to cocaine, both CREB and deltaFosB play a role in the induction of this behavioural sensitization. ..
  14. Levine A, Guan Z, Barco A, Xu S, Kandel E, Schwartz J. CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum. Proc Natl Acad Sci U S A. 2005;102:19186-91 pubmed
    ..binding protein (CREB)-binding protein (CBP) mediates sensitivity to cocaine by regulating expression of the fosB gene and its splice variant, DeltafosB, a transcription factor previously implicated in addiction...
  15. Hiroi N, Brown J, Haile C, Ye H, Greenberg M, Nestler E. FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects. Proc Natl Acad Sci U S A. 1997;94:10397-402 pubmed
    ..In the present study, the identity and functional role of these Fos-related proteins were examined using fosB mutant mice...
  16. Nomaru H, Sakumi K, Katogi A, Ohnishi Y, Kajitani K, Tsuchimoto D, et al. Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia. Glia. 2014;62:1284-98 pubmed publisher
    The Fosb gene encodes subunits of the activator protein-1 transcription factor complex. Two mature mRNAs, Fosb and ?Fosb, encoding full-length FOSB and ?FOSB proteins respectively, are formed by alternative splicing of Fosb mRNA...
  17. Pakala S, Singh K, Reddy S, Ohshiro K, Li D, Mishra L, et al. TGF-?1 signaling targets metastasis-associated protein 1, a new effector in epithelial cells. Oncogene. 2011;30:2230-41 pubmed publisher
    ..In addition, we found that MTA1/polymerase II/activator protein-1 (AP-1) co-activator complex interacts with the FosB-gene chromatin and stimulates its transcription, and FosB in turn, utilizes FosB/histone deacetylase 2 complex to ..
  18. Ohnishi Y, Sakumi K, Yamazaki K, Ohnishi Y, Miura T, Tominaga Y, et al. Antagonistic regulation of cell-matrix adhesion by FosB and DeltaFosB/Delta2DeltaFosB encoded by alternatively spliced forms of fosB transcripts. Mol Biol Cell. 2008;19:4717-29 pubmed publisher
    Among fos family genes encoding components of activator protein-1 complex, only the fosB gene produces two forms of mature transcripts, namely fosB and DeltafosB mRNAs, by alternative splicing of an exonic intron...
  19. Alfonso Jaume M, Bergman M, Mahimkar R, Cheng S, Jin Z, Karliner J, et al. Cardiac ischemia-reperfusion injury induces matrix metalloproteinase-2 expression through the AP-1 components FosB and JunB. Am J Physiol Heart Circ Physiol. 2006;291:H1838-46 pubmed
    ..Nuclear extracts demonstrated increased abundance of two activator proteins-1 (AP-1) components JunB and FosB following I/R injury...
  20. Lim J, Catez F, Birger Y, West K, Prymakowska Bosak M, Postnikov Y, et al. Chromosomal protein HMGN1 modulates histone H3 phosphorylation. Mol Cell. 2004;15:573-84 pubmed
    ..Thus, the levels of posttranslational modifications in chromatin are modulated by nucleosome binding proteins that alter the ability of enzymatic complexes to access and modify their nucleosomal targets. ..
  21. Werme M, Messer C, Olson L, Gilden L, Thoren P, Nestler E, et al. Delta FosB regulates wheel running. J Neurosci. 2002;22:8133-8 pubmed
  22. Ramachandran A, Gong E, Pelton K, Ranpura S, Mulone M, Seth A, et al. FosB regulates stretch-induced expression of extracellular matrix proteins in smooth muscle. Am J Pathol. 2011;179:2977-89 pubmed publisher
    ..Herein, we identify a novel role for the AP-1 subunit FosB in stretch-induced ECM expression in SMCs...
  23. Vierbuchen T, Ling E, Cowley C, Couch C, Wang X, Harmin D, et al. AP-1 Transcription Factors and the BAF Complex Mediate Signal-Dependent Enhancer Selection. Mol Cell. 2017;68:1067-1082.e12 pubmed publisher
    ..These experiments demonstrate how environmental signals acting via FOS/JUN and BAF coordinate with cell-type-specific TFs to select enhancer repertoires that enable differentiation during development. ..
  24. Vialou V, Cui H, Perello M, Mahgoub M, Yu H, RUSH A, et al. A role for ?FosB in calorie restriction-induced metabolic changes. Biol Psychiatry. 2011;70:204-7 pubmed publisher
    ..and refeeding, mice were assessed by behavioral and metabolic studies and for levels of the transcription factor ?FosB. The ?FosB levels were then increased specifically in nucleus accumbens (NAc) with viral-mediated gene transfer, ..
  25. Millien G, Spira A, Hinds A, Wang J, Williams M, Ramirez M. Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development. BMC Dev Biol. 2006;6:35 pubmed
    ..5. At term, FosB, Egr1, MPK-1 and Nur77, which can function as negative regulators of the cell-cycle, are down-regulated...
  26. Vialou V, ROBISON A, LaPlant Q, Covington H, Dietz D, Ohnishi Y, et al. DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nat Neurosci. 2010;13:745-52 pubmed publisher
    ..Together, these findings establish a previously unknown molecular pathway underlying both resilience and antidepressant action. ..
  27. Berton O, Covington H, Ebner K, Tsankova N, Carle T, Ulery P, et al. Induction of deltaFosB in the periaqueductal gray by stress promotes active coping responses. Neuron. 2007;55:289-300 pubmed
    ..These results indicate that IS-induced accumulation of DeltaFosB in the vlPAG desensitizes substance P neurons enriched in this area and opposes behavioral despair by promoting active defense responses. ..
  28. Sabatakos G, Rowe G, Kveiborg M, Wu M, Neff L, Chiusaroli R, et al. Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity. J Bone Miner Res. 2008;23:584-95 pubmed publisher
    ..Transgenic mice that overexpress the naturally occurring DeltaFosB splice variant of FosB develop severe osteosclerosis...
  29. Unterwald E, Ivkovic S, Cuntapay M, Stroppolo A, Guinea B, Ehrlich M. Prenatal exposure to cocaine decreases adenylyl cyclase activity in embryonic mouse striatum. Brain Res Dev Brain Res. 2003;147:67-75 pubmed
    ..Alterations in the cAMP system may underlie some of the deficits seen in humans exposed in utero to cocaine. ..
  30. Lazenka M, Tomarchio A, Lichtman A, Greengard P, Flajolet M, Selley D, et al. Role of Dopamine Type 1 Receptors and Dopamine- and cAMP-Regulated Phosphoprotein Mr 32 kDa in Δ9-Tetrahydrocannabinol-Mediated Induction of ΔFosB in the Mouse Forebrain. J Pharmacol Exp Ther. 2015;354:316-27 pubmed publisher
    ..repeated administration of THC attenuated induction of Δ FBJ murine osteosarcoma viral oncogene homolog B (ΔFosB) in the nucleus accumbens, caudate-putamen, amygdala, and prefrontal cortex...
  31. Radwanska K, Valjent E, Trzaskos J, Caboche J, Kaczmarek L. Regulation of cocaine-induced activator protein 1 transcription factors by the extracellular signal-regulated kinase pathway. Neuroscience. 2006;137:253-64 pubmed
    ..shown that extracellular signal-regulated kinase activation can regulate cocaine-induced expression of c-Fos and FosB, two possible components of activator protein 1...
  32. Hall M, Young D, Waters J, Rowan A, Chantry A, Edwards D, et al. The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1. J Biol Chem. 2003;278:10304-13 pubmed
    ..In contrast, Smads do interact with the MMP-1 AP1 site and mediate repression of induced MMP-1 gene expression by TGF-beta1. ..
  33. Brown J, Nigh E, Lee R, Ye H, Thompson M, Saudou F, et al. Fos family members induce cell cycle entry by activating cyclin D1. Mol Cell Biol. 1998;18:5609-19 pubmed
    ..To address this issue, mice that lack two members of the fos family, c-fos and fosB, were derived. The fosB-/- c-fos-/- mice are similar in phenotype to c-fos-/- mice but are 30% smaller...
  34. Brown J, Ye H, Bronson R, Dikkes P, Greenberg M. A defect in nurturing in mice lacking the immediate early gene fosB. Cell. 1996;86:297-309 pubmed
    ..To address this issue, mice were generated with an inactivating mutation in the fosB gene...
  35. Ulery Reynolds P, Castillo M, Vialou V, Russo S, Nestler E. Phosphorylation of DeltaFosB mediates its stability in vivo. Neuroscience. 2009;158:369-72 pubmed publisher
    ..We show here that this phosphorylation reaction is also important for DeltaFosB's stability in the brain in vivo and for the unique behavioral plasticity mediated by this transcription factor. ..
  36. Phillips R, Ernst R, Brunk B, Ivanova N, Mahan M, Deanehan J, et al. The genetic program of hematopoietic stem cells. Science. 2000;288:1635-40 pubmed
    ..The complete data, available in a biological process-oriented database, represent the molecular phenotype of the hematopoietic stem cell. ..
  37. Kelz M, Kuszak J, Yang Y, Ma W, Steffen C, Al Ghoul K, et al. DeltaFosB-induced cataract. Invest Ophthalmol Vis Sci. 2000;41:3523-38 pubmed
    ..By identifying DeltaFosB-regulated target genes, it should be possible to achieve a better understanding of the molecular mechanisms through which PSC is formed. ..
  38. Xu G, Duan S, Hou J, Wei Z, Zhao G. GosB Inhibits Triacylglycerol Synthesis and Promotes Cell Survival in Mouse Mammary Epithelial Cells. Biomed Res Int. 2017;2017:7394869 pubmed publisher
    ..These findings suggest that GosB may regulate mammary epithelial cells milk fat synthesis and apoptosis via PPAR? in mouse mammary glands. ..
  39. Enwright J, Wald M, Paddock M, Hoffman E, Arey R, Edwards S, et al. DeltaFosB indirectly regulates Cck promoter activity. Brain Res. 2010;1329:10-20 pubmed publisher
    ..increase in the expression of numerous genes in striatum, most of which are later downregulated following 8weeks of FosB expression...
  40. Herdegen T, Leah J. Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. Brain Res Brain Res Rev. 1998;28:370-490 pubmed findings up to the end of 1997 about the inducible transcription factors (ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A, Egr-1, Zif268); and the constitutive transcription factors (..
  41. OZBURN A, Mayfield R, Ponomarev I, Jones T, Blednov Y, Harris R. Chronic self-administration of alcohol results in elevated ?FosB: comparison of hybrid mice with distinct drinking patterns. BMC Neurosci. 2012;13:130 pubmed publisher
    ..hypothesis that these phenotypes are represented by differential production of the inducible transcription factor, ?FosB, in reward, aversion, and stress related brain regions...
  42. Frenois F, Moreau M, O Connor J, Lawson M, Micon C, Lestage J, et al. Lipopolysaccharide induces delayed FosB/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior. Psychoneuroendocrinology. 2007;32:516-31 pubmed
    ..Concurrently, the expression of acute and chronic cellular reactivity markers (c-Fos and FosB/DeltaFosB, respectively) was mapped by immunohistochemistry at these two time points...
  43. Eagle A, Gajewski P, Yang M, Kechner M, Al Masraf B, Kennedy P, et al. Experience-Dependent Induction of Hippocampal ΔFosB Controls Learning. J Neurosci. 2015;35:13773-83 pubmed publisher
    ..b>FosB is a transcription factor that is induced throughout the brain by chronic exposure to drugs, stress, and variety of ..
  44. Yutsudo N, Kamada T, Kajitani K, Nomaru H, Katogi A, Ohnishi Y, et al. fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior. Neuropsychopharmacology. 2013;38:895-906 pubmed publisher
    ..The expression of fosB, an immediate early gene encoding FosB and ?FosB/?2?FosB by alternative splicing and translation initiation, is ..
  45. Mathieson W, Wilkinson M, Brown R, Bond T, Taylor S, Neumann P. FOS and FOSB expression in the medial preoptic nucleus pars compacta of maternally active C57BL/6J and DBA/2J mice. Brain Res. 2002;952:170-5 pubmed
    ..To determine whether MPOpc cells are activated by maternal behavior, FOS and FOSB immunohistochemistry was performed on brain sections of C57BL/6J and DBA/2J mothers following the return of their ..
  46. Kveiborg M, Sabatakos G, Chiusaroli R, Wu M, Philbrick W, Horne W, et al. DeltaFosB induces osteosclerosis and decreases adipogenesis by two independent cell-autonomous mechanisms. Mol Cell Biol. 2004;24:2820-30 pubmed
    ..It is concluded that the changes in osteoblast and adipocyte differentiation in DeltaFosB transgenic mice result from independent cell-autonomous mechanisms...
  47. Gong P, Stewart D, Hu B, Vinson C, Alam J. Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite. Arch Biochem Biophys. 2002;405:265-74 pubmed
    ..MafG, ATF2, FosB, and JunB were also detected in the arsenite complex...
  48. Glass D, Bialek P, Ahn J, Starbuck M, Patel M, Clevers H, et al. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. 2005;8:751-64 pubmed
  49. Muschamp J, Nemeth C, ROBISON A, Nestler E, Carlezon W. ?FosB enhances the rewarding effects of cocaine while reducing the pro-depressive effects of the kappa-opioid receptor agonist U50488. Biol Psychiatry. 2012;71:44-50 pubmed publisher
    Elevated expression of the transcription factor ?FosB accompanies repeated exposure to drugs of abuse, particularly in brain areas associated with reward and motivation (e.g., nucleus accumbens)...
  50. Mandelzys A, Gruda M, Bravo R, Morgan J. Absence of a persistently elevated 37 kDa fos-related antigen and AP-1-like DNA-binding activity in the brains of kainic acid-treated fosB null mice. J Neurosci. 1997;17:5407-15 pubmed
    ..However, the composition and function of these AP-1 complexes remain controversial. By comparing wild-type and fosB-null mice treated with kainic acid, we establish that the complexes comprise JunD in association with an ..
  51. Heller E, Cates H, Pena C, Sun H, Shao N, Feng J, et al. Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors. Nat Neurosci. 2014;17:1720-7 pubmed publisher
    ..We found that histone methylation or acetylation at the Fosb locus in nucleus accumbens, a brain reward region, was sufficient to control drug- and stress-evoked ..
  52. Feyder M, Södersten E, Santini E, Vialou V, LaPlant Q, Watts E, et al. A Role for Mitogen- and Stress-Activated Kinase 1 in L-DOPA-Induced Dyskinesia and ∆FosB Expression. Biol Psychiatry. 2016;79:362-71 pubmed publisher
    ..6-Hydroxydopamine was used to produce a model of Parkinson's disease in MSK1 knockout mice and in ∆FosB- or ∆cJun-overexpressing transgenic mice, which were assessed for LID following long-term L-DOPA ..
  53. Gruda M, van Amsterdam J, Rizzo C, Durham S, Lira S, Bravo R. Expression of FosB during mouse development: normal development of FosB knockout mice. Oncogene. 1996;12:2177-85 pubmed
    b>FosB, one of the members of the Fos family, is rapidly induced in many cell types upon stimulation and has a stimulatory effect on the proliferation of cultured cells...
  54. Mondino A, Whaley C, DeSilva D, Li W, Jenkins M, Mueller D. Defective transcription of the IL-2 gene is associated with impaired expression of c-Fos, FosB, and JunB in anergic T helper 1 cells. J Immunol. 1996;157:2048-57 pubmed
    ..interactions in anergic T cells were associated with poor expression of the inducible AP-1 family members c-Fos, FosB, and JunB...
  55. Vialou V, Bagot R, Cahill M, Ferguson D, ROBISON A, Dietz D, et al. Prefrontal cortical circuit for depression- and anxiety-related behaviors mediated by cholecystokinin: role of ?FosB. J Neurosci. 2014;34:3878-87 pubmed publisher
    ..We show here that induction of the transcription factor ?FosB in mPFC, specifically in the prelimbic (PrL) area, mediates susceptibility to stress...
  56. Qiang M, Ticku M. Role of AP-1 in ethanol-induced N-methyl-D-aspartate receptor 2B subunit gene up-regulation in mouse cortical neurons. J Neurochem. 2005;95:1332-41 pubmed
    ..The AP-1 DNA-binding complex in control and ethanol-treated nuclear extract was composed of c-Fos, FosB, c-Jun, JunD, and phosphorylated CREB (p-CREB)...
  57. Ivandic B, Utz H, Kaczmarek P, Aherrahrou Z, Axtner S, Klepsch C, et al. New Dyscalc loci for myocardial cell necrosis and calcification (dystrophic cardiac calcinosis) in mice. Physiol Genomics. 2001;6:137-44 pubmed
    ..Additive epistasis between Dyscalc1 and Dyscalc2 enhanced DCC. Examining recombinant inbred strains, we propose a 10-cM interval containing Dyscalc1 and discuss potential candidate genes...
  58. Kuroda K, Meaney M, Uetani N, Fortin Y, Ponton A, Kato T. ERK-FosB signaling in dorsal MPOA neurons plays a major role in the initiation of parental behavior in mice. Mol Cell Neurosci. 2007;36:121-31 pubmed the dorsal medial preoptic area (MPOAd) are activated and express transcription factors such as c-Fos and FosB. FosB-knockout mice are reported to be defective in parental care...
  59. Suzuki T, Yamashita S, Ushijima T, Takumi S, Sano T, Michikawa T, et al. Genome-wide analysis of DNA methylation changes induced by gestational arsenic exposure in liver tumors. Cancer Sci. 2013;104:1575-85 pubmed publisher
    ..Among such regions, we showed that a gene body region of the oncogene Fosb underwent alteration in DNA methylation by gestational arsenic exposure...
  60. Solecki W, Krowka T, Kubik J, Kaczmarek L, Przewlocki R. Role of fosB in behaviours related to morphine reward and spatial memory. Behav Brain Res. 2008;190:212-7 pubmed publisher
    ..b>fosB, which belongs to IEG, has been reported to have pleiotropic impact on response to psychoactive drugs, as well as ..
  61. Kormos V, Gaspar L, Kovács L, Farkas J, Gaszner T, Csernus V, et al. Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers. Neuroscience. 2016;330:335-58 pubmed publisher
    ..wildtype (WT) counterparts. We hypothesized reduced FosB neuronal activity in stress-related centers, altered activity and peptide/neurotransmitter content of corticotropin-..
  62. Zhu H, Lee M, Agatsuma S, Hiroi N. Pleiotropic impact of constitutive fosB inactivation on nicotine-induced behavioral alterations and stress-related traits in mice. Hum Mol Genet. 2007;16:820-36 pubmed
    ..have shown that many addictive substances and stressful stimuli increase the expression of the transcription factor FosB in limbic and associated regions and that the protein products of fosB contribute to certain behavioral effects of ..
  63. Ohnishi Y, Ohnishi Y, Hokama M, Nomaru H, Yamazaki K, Tominaga Y, et al. FosB is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ?FosB. Biol Psychiatry. 2011;70:487-95 pubmed publisher
    Molecular mechanisms underlying stress tolerance and vulnerability are incompletely understood. The fosB gene is an attractive candidate for regulating stress responses, because ?FosB, an alternative splice product of the fosB gene, ..
  64. Geisler J, Stubbs L, Wasserman W, Mucenski M. Molecular cloning of a novel mouse gene with predominant muscle and neural expression. Mamm Genome. 1998;9:274-82 pubmed
    ..In addition, the putative regulatory domains of Nspl1 appear similar in composition and distribution to the defined dystrophin regulatory sequences. ..
  65. Zerial M, Toschi L, Ryseck R, Schuermann M, Muller R, Bravo R. The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity. EMBO J. 1989;8:805-13 pubmed
    ..Gel retardation assays demonstrated that fos B protein positively influences the binding of c-jun and jun B proteins to an AP-1 binding consensus sequence, suggesting that fos B protein plays a role in control of gene expression. ..
  66. Eferl R, Sibilia M, Hilberg F, Fuchsbichler A, Kufferath I, Guertl B, et al. Functions of c-Jun in liver and heart development. J Cell Biol. 1999;145:1049-61 pubmed