Fos

Summary

Gene Symbol: Fos
Description: FBJ osteosarcoma oncogene
Alias: D12Rfj1, c-fos, cFos, proto-oncogene c-Fos, cellular oncogene fos, proto-oncogene protein c-fos
Species: mouse
Products:     Fos

Top Publications

  1. Roffler Tarlov S, Brown J, Tarlov E, Stolarov J, Chapman D, Alexiou M, et al. Programmed cell death in the absence of c-Fos and c-Jun. Development. 1996;122:1-9 pubmed
    ..the transcription factor, AP-1, in the regulation of programmed cell death, and specifically implicate the genes c-fos and c-jun, as well as some other family members...
  2. Lackinger D, Kaina B. Primary mouse fibroblasts deficient for c-Fos, p53 or for both proteins are hypersensitive to UV light and alkylating agent-induced chromosomal breakage and apoptosis. Mutat Res. 2000;457:113-23 pubmed
    The important regulatory proteins, c-Fos and p53 are induced by exposure of cells to a variety of DNA damaging agents...
  3. Tanos T, Marinissen M, Leskow F, Hochbaum D, Martinetto H, Gutkind J, et al. Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light. J Biol Chem. 2005;280:18842-52 pubmed
    ..Among them, the rapid activation of genes coding for two subfamilies of proto-oncoproteins, Fos and Jun, which constitute the AP-1 transcription factor, plays a key role in the subsequent regulation of ..
  4. Miao G, Curran T. Cell transformation by c-fos requires an extended period of expression and is independent of the cell cycle. Mol Cell Biol. 1994;14:4295-310 pubmed
    The proto-oncogene transcription factors Fos and Jun form a heterodimeric complex that binds to DNA and regulates expression of specific target genes...
  5. Hafezi F, Steinbach J, Marti A, Munz K, Wang Z, Wagner E, et al. The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo. Nat Med. 1997;3:346-9 pubmed
    ..Although recent evidence indicates that the proto-oncogene c-fos is a mediator of apoptosis, its precise role is unclear...
  6. Huerta J, Llamosas M, Cernuda Cernuda R, Garcia Fernandez J. Fos expression in the retina of rd/rd mice during the light/dark cycle. Neurosci Lett. 1997;232:143-6 pubmed
    An anti-Fos protein antiserum was used to elucidate the diurnal expression of Fos protein in the normal and degenerate rd/rd mice retina...
  7. Yamashita T, Yao Z, Li F, Zhang Q, Badell I, Schwarz E, et al. NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. J Biol Chem. 2007;282:18245-53 pubmed
    ..Osteoclast formation induced by these cytokines requires NF-kappaB p50 and p52, c-Fos, and NFATc1 expression in osteoclast precursors...
  8. Monje P, Marinissen M, Gutkind J. Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor. Mol Cell Biol. 2003;23:7030-43 pubmed
    ..Among them, the AP-1 (activating protein-1) family of transcription factors, including c-Fos and c-Jun family members, plays a key role, as AP-1 activity is potently activated by PDGF and is required to ..
  9. Christmann M, Tomicic M, Origer J, Aasland D, Kaina B. c-Fos is required for excision repair of UV-light induced DNA lesions by triggering the re-synthesis of XPF. Nucleic Acids Res. 2006;34:6530-9 pubmed
    Cells deficient in c-Fos are hypersensitive to ultraviolet (UV-C) light. Here we demonstrate that mouse embryonic fibroblasts lacking c-Fos (fos-/-) are defective in the repair of UV-C induced DNA lesions...
  10. Maruyama K, Takada Y, Ray N, Kishimoto Y, Penninger J, Yasuda H, et al. Receptor activator of NF-kappa B ligand and osteoprotegerin regulate proinflammatory cytokine production in mice. J Immunol. 2006;177:3799-805 pubmed
    ..RANKL-induced tolerance occurred in the absence of c-Fos, which is essential for osteoclast differentiation...

Detail Information

Publications88

  1. Roffler Tarlov S, Brown J, Tarlov E, Stolarov J, Chapman D, Alexiou M, et al. Programmed cell death in the absence of c-Fos and c-Jun. Development. 1996;122:1-9 pubmed
    ..the transcription factor, AP-1, in the regulation of programmed cell death, and specifically implicate the genes c-fos and c-jun, as well as some other family members...
  2. Lackinger D, Kaina B. Primary mouse fibroblasts deficient for c-Fos, p53 or for both proteins are hypersensitive to UV light and alkylating agent-induced chromosomal breakage and apoptosis. Mutat Res. 2000;457:113-23 pubmed
    The important regulatory proteins, c-Fos and p53 are induced by exposure of cells to a variety of DNA damaging agents...
  3. Tanos T, Marinissen M, Leskow F, Hochbaum D, Martinetto H, Gutkind J, et al. Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light. J Biol Chem. 2005;280:18842-52 pubmed
    ..Among them, the rapid activation of genes coding for two subfamilies of proto-oncoproteins, Fos and Jun, which constitute the AP-1 transcription factor, plays a key role in the subsequent regulation of ..
  4. Miao G, Curran T. Cell transformation by c-fos requires an extended period of expression and is independent of the cell cycle. Mol Cell Biol. 1994;14:4295-310 pubmed
    The proto-oncogene transcription factors Fos and Jun form a heterodimeric complex that binds to DNA and regulates expression of specific target genes...
  5. Hafezi F, Steinbach J, Marti A, Munz K, Wang Z, Wagner E, et al. The absence of c-fos prevents light-induced apoptotic cell death of photoreceptors in retinal degeneration in vivo. Nat Med. 1997;3:346-9 pubmed
    ..Although recent evidence indicates that the proto-oncogene c-fos is a mediator of apoptosis, its precise role is unclear...
  6. Huerta J, Llamosas M, Cernuda Cernuda R, Garcia Fernandez J. Fos expression in the retina of rd/rd mice during the light/dark cycle. Neurosci Lett. 1997;232:143-6 pubmed
    An anti-Fos protein antiserum was used to elucidate the diurnal expression of Fos protein in the normal and degenerate rd/rd mice retina...
  7. Yamashita T, Yao Z, Li F, Zhang Q, Badell I, Schwarz E, et al. NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. J Biol Chem. 2007;282:18245-53 pubmed
    ..Osteoclast formation induced by these cytokines requires NF-kappaB p50 and p52, c-Fos, and NFATc1 expression in osteoclast precursors...
  8. Monje P, Marinissen M, Gutkind J. Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor. Mol Cell Biol. 2003;23:7030-43 pubmed
    ..Among them, the AP-1 (activating protein-1) family of transcription factors, including c-Fos and c-Jun family members, plays a key role, as AP-1 activity is potently activated by PDGF and is required to ..
  9. Christmann M, Tomicic M, Origer J, Aasland D, Kaina B. c-Fos is required for excision repair of UV-light induced DNA lesions by triggering the re-synthesis of XPF. Nucleic Acids Res. 2006;34:6530-9 pubmed
    Cells deficient in c-Fos are hypersensitive to ultraviolet (UV-C) light. Here we demonstrate that mouse embryonic fibroblasts lacking c-Fos (fos-/-) are defective in the repair of UV-C induced DNA lesions...
  10. Maruyama K, Takada Y, Ray N, Kishimoto Y, Penninger J, Yasuda H, et al. Receptor activator of NF-kappa B ligand and osteoprotegerin regulate proinflammatory cytokine production in mice. J Immunol. 2006;177:3799-805 pubmed
    ..RANKL-induced tolerance occurred in the absence of c-Fos, which is essential for osteoclast differentiation...
  11. Kruijer W, Cooper J, Hunter T, Verma I. Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein. Nature. 1984;312:711-6 pubmed
    Exposure of quiescent mouse fibroblasts to platelet-derived growth factor induces mRNA from the c-fos proto-oncogene within 10 min followed by synthesis of nuclear c-fos proteins...
  12. Van Beveren C, van Straaten F, Curran T, Muller R, Verma I. Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini. Cell. 1983;32:1241-55 pubmed
    The complete nucleotide sequence of the FBJ-MuSV proviral DNA and the cellular homolog (c-fos) of its oncogene (v-fos) have been determined...
  13. Charital Y, Van Haasteren G, Massiha A, Schlegel W, Fujita T. A functional NF-kappaB enhancer element in the first intron contributes to the control of c-fos transcription. Gene. 2009;430:116-22 pubmed publisher
    ..Such regulation is important for the transcription of immediate early genes (IEGs) and in particular for the c-fos gene, the first intron of which contains many potential transcription factor binding elements...
  14. Fleischmann A, Hvalby O, Jensen V, Strekalova T, Zacher C, Layer L, et al. Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS. J Neurosci. 2003;23:9116-22 pubmed
    The immediate early gene c-fos is part of the activator protein-1 transcription factor and has been postulated to participate in the molecular mechanisms of learning and memory...
  15. Fleischmann A, Hafezi F, Elliott C, REme C, Ruther U, Wagner E. Fra-1 replaces c-Fos-dependent functions in mice. Genes Dev. 2000;14:2695-700 pubmed
    ..analysis as well as studies with knock-out and transgenic mice have assigned distinct functions to c-Fos and Fra-1, two components of the transcription factor AP-1 (activator protein-1)...
  16. Ely H, Mellon P, Coss D. GnRH induces the c-Fos gene via phosphorylation of SRF by the calcium/calmodulin kinase II pathway. Mol Endocrinol. 2011;25:669-80 pubmed publisher
    ..subunit genes, very little is known about mechanism of induction of intermediary immediate early genes, such as c-Fos, that are direct targets of GnRH signaling and that upon induction, activate transcription of gonadotropin genes...
  17. Wang Z, Ovitt C, Grigoriadis A, Möhle Steinlein U, Ruther U, Wagner E. Bone and haematopoietic defects in mice lacking c-fos. Nature. 1992;360:741-5 pubmed
    The proto-oncogene c-fos is the cellular homologue of v-fos originally isolated from murine osteosarcoma. Fos protein is a major component of the AP-1 transcription factor complex, which includes members of the jun family...
  18. Semo M, Lupi D, Peirson S, Butler J, Foster R. Light-induced c-fos in melanopsin retinal ganglion cells of young and aged rodless/coneless (rd/rd cl) mice. Eur J Neurosci. 2003;18:3007-17 pubmed
    ..Using real-time polymerase chain reaction and immunohistochemistry, we address the following. (1) Is Fos expression within these RGCs driven by an input from the rods/cones or is it the product of the intrinsic ..
  19. Matsuo K, Galson D, Zhao C, Peng L, Laplace C, Wang K, et al. Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. J Biol Chem. 2004;279:26475-80 pubmed
    Osteoclasts are specialized macrophages that resorb bone. Mice lacking the AP-1 component c-Fos are osteopetrotic because of a lack of osteoclast differentiation and show an increased number of macrophages...
  20. Paylor R, Johnson R, Papaioannou V, Spiegelman B, Wehner J. Behavioral assessment of c-fos mutant mice. Brain Res. 1994;651:275-82 pubmed
    Induction of the proto-oncogene c-fos has been associated with a number of neural and behavioral responses to acute stimuli...
  21. Maruyama K, Sano G, Ray N, Takada Y, Matsuo K. c-Fos-deficient mice are susceptible to Salmonella enterica serovar Typhimurium infection. Infect Immun. 2007;75:1520-3 pubmed
    c-Fos is a component of transcription factor AP-1...
  22. Watanabe Y, Johnson R, Butler L, Binder D, Spiegelman B, Papaioannou V, et al. Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy. J Neurosci. 1996;16:3827-36 pubmed
    It has been suggested that expression of the immediate early gene c-fos links fleeting changes in neuronal activity to lasting modifications of neuronal structure and function in the mammalian nervous system...
  23. Curran T, Miller A, Zokas L, Verma I. Viral and cellular fos proteins: a comparative analysis. Cell. 1984;36:259-68 pubmed
    ..It contains an oncogene termed v-fos derived from a normal cellular gene by recombination with an associated helper virus...
  24. Miller A, Curran T, Verma I. c-fos protein can induce cellular transformation: a novel mechanism of activation of a cellular oncogene. Cell. 1984;36:51-60 pubmed
    ..Transformation is due to the expression of a single viral protein (p55v-fos) which is encoded by sequences derived from mouse genetic material...
  25. Asagiri M, Sato K, Usami T, Ochi S, Nishina H, Yoshida H, et al. Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med. 2005;202:1261-9 pubmed
    ..differentiation in vivo by adoptive transfer of NFATc1(-/-) hematopoietic stem cells to osteoclast-deficient Fos(-/-) mice, and by Fos(-/-) blastocyst complementation, thus avoiding the embryonic lethality of NFATc1(-/-) mice...
  26. Renz M, Neuberg M, Kurz C, Bravo R, Muller R. Regulation of c-fos transcription in mouse fibroblasts: identification of DNase I-hypersensitive sites and regulatory upstream sequences. EMBO J. 1985;4:3711-6 pubmed
    In quiescent mouse fibroblasts, the c-fos gene is expressed at very low levels, but is rapidly and transiently inducible by peptide growth factors...
  27. Takayanagi H, Kim S, Matsuo K, Suzuki H, Suzuki T, Sato K, et al. RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature. 2002;416:744-9 pubmed
    ..cells, and that IFN-beta inhibits the differentiation by interfering with the RANKL-induced expression of c-Fos, an essential transcription factor for the formation of osteoclasts...
  28. Ito Y, Inoue D, Kido S, Matsumoto T. c-Fos degradation by the ubiquitin-proteasome proteolytic pathway in osteoclast progenitors. Bone. 2005;37:842-9 pubmed
    c-Fos is an immediate early gene type proto-oncogene that belongs to the AP (activator protein)-1 transcription factor family...
  29. Johnson R, Spiegelman B, Papaioannou V. Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell. 1992;71:577-86 pubmed
    The c-fos proto-oncogene has been implicated as a central regulatory component of the nuclear response to mitogens and other extracellular stimuli...
  30. Lee G, Gilman M. Dual modes of control of c-fos mRNA induction by intracellular calcium in T cells. Mol Cell Biol. 1994;14:4579-87 pubmed
    ..examine the molecular mechanisms through which these agents exert synergistic control over the expression of the c-fos proto-oncogene in a T-cell hybridoma...
  31. CLARK C, Hasan M, Bousso P. A role for the immediate early gene product c-fos in imprinting T cells with short-term memory for signal summation. PLoS ONE. 2011;6:e18916 pubmed publisher
    ..Upregulation of the immediate early gene product c-fos, a component of the AP-1 transcription factor, was maximal by 1-2 hours of stimulation, and protein levels remained ..
  32. Eferl R, Sibilia M, Hilberg F, Fuchsbichler A, Kufferath I, Guertl B, et al. Functions of c-Jun in liver and heart development. J Cell Biol. 1999;145:1049-61 pubmed
  33. Herdegen T, Leah J. Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. Brain Res Brain Res Rev. 1998;28:370-490 pubmed
    ..reviews findings up to the end of 1997 about the inducible transcription factors (ITFs) c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2, Krox-20 (Egr-2) and Krox-24 (NGFI-A, Egr-1, Zif268); and the constitutive transcription ..
  34. Grigoriadis A, Wang Z, Cecchini M, Hofstetter W, Felix R, Fleisch H, et al. c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science. 1994;266:443-8 pubmed
    Mice lacking the proto-oncogene c-fos develop the bone disease osteopetrosis. Fos mutant mice were found to have a block in the differentiation of bone-resorbing osteoclasts that was intrinsic to hematopoietic cells...
  35. Jain J, Nalefski E, McCaffrey P, Johnson R, Spiegelman B, Papaioannou V, et al. Normal peripheral T-cell function in c-Fos-deficient mice. Mol Cell Biol. 1994;14:1566-74 pubmed
    The ubiquitous transcription factors Fos and Jun are rapidly induced in T cells stimulated through the T-cell antigen receptor and regulate transcription of cytokines, including interleukin 2, in activated T cells...
  36. Wahlin K, Adler R, Zack D, Campochiaro P. Neurotrophic signaling in normal and degenerating rodent retinas. Exp Eye Res. 2001;73:693-701 pubmed
    ..by performing immunohistochemical staining for the phosphorylated form of extracellular receptor kinase (pERK) or c-fos after intravitreous injection of neurotrophic factors in wild type rats or mice, or those with inherited retinal ..
  37. Dillon S, Agrawal A, Van Dyke T, Landreth G, McCauley L, Koh A, et al. A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells. J Immunol. 2004;172:4733-43 pubmed
    ..suppressed IL-12(p70) and enhanced IL-10 production, as well as enhanced induction of the transcription factor, c-Fos. Interestingly, DCs from c-fos(-/-) mice produce more IL-12(p70), but less IL-10, compared with control DCs...
  38. Yang D, Smith E, Cai K, Xu X. C-Fos elimination compensates for disabled-2 requirement in mouse extraembryonic endoderm development. Dev Dyn. 2009;238:514-23 pubmed publisher
    ..5-E6.5 due to the disorganization of the endoderm layers. Here we show that Dab2 suppresses c-Fos expression in endoderm cells. A morphological normal primitive endoderm layer was observed in putative E5...
  39. Hill C, Würfel A, Heger J, Meyering B, Schluter K, Weber M, et al. Inhibition of AP-1 signaling by JDP2 overexpression protects cardiomyocytes against hypertrophy and apoptosis induction. Cardiovasc Res. 2013;99:121-8 pubmed publisher
    ..Therefore, AP-1 acts as a double-edged sword that mediates mal-adaptive cardiac remodelling, but is required for maintaining a proper contractile function of cardiomyocytes. ..
  40. Dong M, Wu Y, Fan Y, Xu M, Zhang J. c-fos modulates brain-derived neurotrophic factor mRNA expression in mouse hippocampal CA3 and dentate gyrus neurons. Neurosci Lett. 2006;400:177-80 pubmed
    ..Our previous studies using a mouse with hippocampal c-fos gene deletion showed that c-fos regulates neuronal excitability and excitotoxicity...
  41. Martins G, Cimmino L, Liao J, Magnusdottir E, Calame K. Blimp-1 directly represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival. J Exp Med. 2008;205:1959-65 pubmed publisher
    ..cells is to repress IL-2, and that it does so by direct repression of Il2 transcription, and also by repression of Fos transcription...
  42. Geller S, Guerin K, Visel M, Pham A, Lee E, Dror A, et al. CLRN1 is nonessential in the mouse retina but is required for cochlear hair cell development. PLoS Genet. 2009;5:e1000607 pubmed publisher
    ..If CLRN1 expression in humans is comparable to the expression pattern observed in mice, this is the first report of an inner retinal protein that, when mutated, causes retinal degeneration. ..
  43. Ross S, Mardinly A, McCord A, Zurawski J, Cohen S, Jung C, et al. Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron. 2010;65:886-98 pubmed publisher
    ..Our findings suggest that Bhlhb5 is required for the survival of a specific population of inhibitory interneurons that regulate pruritus, and provide evidence that the loss of inhibitory synaptic input results in abnormal itch. ..
  44. Mistry D, Tsutsumi R, Fernandez M, Sharma S, Cardenas S, Lawson M, et al. Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-beta gene is mediated by differential expression of positive regulatory activator protein 1 factors and corepressors SKIL and TGIF1. Mol Endocrinol. 2011;25:1387-403 pubmed publisher
    ..By mining a previous microarray data set, we found that mRNA for positive regulators of Fshb expression, such as Fos and Jun, were up-regulated at slower pulse frequencies than a number of potential negative regulators, such as the ..
  45. Brown J, Nigh E, Lee R, Ye H, Thompson M, Saudou F, et al. Fos family members induce cell cycle entry by activating cyclin D1. Mol Cell Biol. 1998;18:5609-19 pubmed
    Expression of the fos family of transcription factors is stimulated by growth factors that induce quiescent cells to reenter the cell cycle, but the cellular targets of the Fos family that regulate cell cycle reentry have not been ..
  46. Tannenbaum C, Koerner T, Jansen M, Hamilton T. Characterization of lipopolysaccharide-induced macrophage gene expression. J Immunol. 1988;140:3640-5 pubmed
    ..with a set of cDNA encoding other inducible gene products, including TNF, IL-1, ornithine decarboxylase, c-myc, c-fos, JE, or KC...
  47. Oliver G, Wehr R, Jenkins N, Copeland N, Cheyette B, Hartenstein V, et al. Homeobox genes and connective tissue patterning. Development. 1995;121:693-705 pubmed
    ..Six 1 and Six 2 also are expressed in skeletal and smooth muscle, respectively. These genes may participate in the patterning of the distal tendons of the limb phalanges by setting positional values along the limb axes. ..
  48. Birkenmeier C, McFarland Starr E, Barker J. Chromosomal location of three spectrin genes: relationship to the inherited hemolytic anemias of mouse and man. Proc Natl Acad Sci U S A. 1988;85:8121-5 pubmed
    ..Analysis of the data from the chromosome 12 study defines a new order for the genes on that chromosome and delineates the largest mouse/human conserved chromosomal segment yet known. ..
  49. Peng T, Zhang T, Lu X, Feng Q. JNK1/c-fos inhibits cardiomyocyte TNF-alpha expression via a negative crosstalk with ERK and p38 MAPK in endotoxaemia. Cardiovasc Res. 2009;81:733-41 pubmed publisher
    ..JNK1 activation by LPS also induced immediate c-fos expression in cardiomyocytes, which was blocked by inhibition of JNK1 signalling...
  50. Cai K, Qi D, Wang O, Chen J, Deng B, Qian L, et al. TNF-? acutely upregulates amylin expression in murine pancreatic beta cells. Diabetologia. 2011;54:617-26 pubmed publisher
    ..or protein kinase C? (PKC(?)), (2) MIN6 cells expressing a c-Jun-dominant negative construct and (3) islets from Fos knockout mice demonstrated that TNF-? induced amylin expression through the PKC(?)-extracellular signal-regulated ..
  51. Sladek R, Beatty B, Squire J, Copeland N, Gilbert D, Jenkins N, et al. Chromosomal mapping of the human and murine orphan receptors ERRalpha (ESRRA) and ERRbeta (ESRRB) and identification of a novel human ERRalpha-related pseudogene. Genomics. 1997;45:320-6 pubmed
    ..1. To our knowledge, this represents the first report of a pseudogene associated with a member of the nuclear receptor superfamily. ..
  52. Ferrero G, Renner M, Gil G, Rodríguez Berdini L, Caputto B. c-Fos-activated synthesis of nuclear phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P?] promotes global transcriptional changes. Biochem J. 2014;461:521-30 pubmed publisher
    c-Fos is a well-recognized member of the AP-1 (activator protein-1) family of transcription factors...
  53. Ghosh A, Chen F, Banerjee S, Xu M, Shneider B. c-Fos mediates repression of the apical sodium-dependent bile acid transporter by fibroblast growth factor-19 in mice. Am J Physiol Gastrointest Liver Physiol. 2014;306:G163-71 pubmed publisher
    ..Responses to FGF-19 were assessed in Caco-2 and CT-26 cells and in mice where c-fos was conditionally silenced in the intestine by a cre-lox strategy...
  54. Hill C, Wynne J, Treisman R. The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell. 1995;81:1159-70 pubmed
    The c-fos serum response element (SRE) forms a ternary complex with the transcription factors SRF (serum response factor) and TCF (ternary complex factor)...
  55. Xu P, Dang Y, Wang L, Liu X, Ren X, Gu J, et al. Lgr4 is crucial for skin carcinogenesis by regulating MEK/ERK and Wnt/?-catenin signaling pathways. Cancer Lett. 2016;383:161-170 pubmed publisher
    ..Collectively, our findings identify Lgr4 as a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 and Wnt/?-catenin pathways. ..
  56. Vara Prasad M, Shore S, Dhanasekaran N. Activated mutant of G alpha 13 induces Egr-1, c-fos, and transformation in NIH 3T3 cells. Oncogene. 1994;9:2425-9 pubmed
    ..response genes, early growth response gene-1 (Egr-1, a nuclear transcription factor with zinc-finger motif) and c-fos (a leucine zipper transcription factor as well as a protooncogene) are constitutively activated in alpha 13Q226L-..
  57. Shirai K, Saika S, Okada Y, Senba E, Ohnishi Y. Expression of c-Fos and c-Jun in developing mouse lens. Ophthalmic Res. 2004;36:226-30 pubmed
    ..in embryonic eye-specific antibodies in the mouse to determine the spatial/temporal expression pattern of c-Fos and c-Jun proteins--the main components of the AP-1 transcription factor, in lens epithelial cells during mouse ..
  58. Schreiber M, Poirier C, Franchi A, Kurzbauer R, Guenet J, Carle G, et al. Structure and chromosomal assignment of the mouse fra-1 gene, and its exclusion as a candidate gene for oc (osteosclerosis). Oncogene. 1997;15:1171-8 pubmed
    ..fra-1 gene, which consists of four exons and three introns at positions also found in the other members of the fos gene family...
  59. Samardzija M, Wenzel A, Aufenberg S, Thiersch M, Reme C, Grimm C. Differential role of Jak-STAT signaling in retinal degenerations. FASEB J. 2006;20:2411-3 pubmed
    ..This suggests a model in which photoreceptor injury is signaled to cells of the inner retina, which in turn initiate a response either to support viability or accelerate death of injured cells. ..
  60. Allen W, DeNardo L, Chen M, Liu C, Loh K, Fenno L, et al. Thirst-associated preoptic neurons encode an aversive motivational drive. Science. 2017;357:1149-1155 pubmed publisher
    ..Thus, the activity of dehydration-activated MnPO neurons establishes a scalable, persistent, and aversive internal state that dynamically controls thirst-motivated behavior. ..
  61. Cobos I, Calcagnotto M, Vilaythong A, Thwin M, Noebels J, Baraban S, et al. Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy. Nat Neurosci. 2005;8:1059-68 pubmed
    ..Dlx1 mutant mice show generalized electrographic seizures and histological evidence of seizure-induced reorganization, linking the Dlx1 mutation to delayed-onset epilepsy associated with interneuron loss. ..
  62. Glaser T, Matthews K, Hudson J, Seth P, Housman D, Crerar M. Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively. Genomics. 1989;5:510-21 pubmed
    ..However, muscle phosphorylase gene structure and expression appear to be unaltered in mdf/mdf mice, indicating that this mutation is not an animal model for the human genetic disorder McArdle's disease. ..
  63. Scheel T, Abajyan A, Baumgrass R. Comment on "constitutive nuclear localization of NFAT in Foxp3(+) regulatory T cells independent of calcineurin activity". J Immunol. 2012;189:4703; author reply 4703-4 pubmed publisher
  64. Edelman D, Meech R, Jones F. The homeodomain protein Barx2 contains activator and repressor domains and interacts with members of the CREB family. J Biol Chem. 2000;275:21737-45 pubmed
    ..Overall, these findings provide a framework for understanding developmental and physiological contexts that influence repressor or activator functions of Barx2. ..
  65. Muthukrishnan S, Yang X, Friesel R, Oxburgh L. Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells. Nat Commun. 2015;6:10027 pubmed publisher
    ..While JUN is regulated by BMP7, we find that its partner FOS is regulated by FGF9...
  66. Jurado J, Fuentes Almagro C, Prieto Alamo M, Pueyo C. Alternative splicing of c-fos pre-mRNA: contribution of the rates of synthesis and degradation to the copy number of each transcript isoform and detection of a truncated c-Fos immunoreactive species. BMC Mol Biol. 2007;8:83 pubmed
    ..Previous analyses based on conventional RT-PCR reported the presence of an unspliced c-fos transcript in several mammalian systems...
  67. Yasoshima Y, Sako N, Senba E, Yamamoto T. Acute suppression, but not chronic genetic deficiency, of c-fos gene expression impairs long-term memory in aversive taste learning. Proc Natl Acad Sci U S A. 2006;103:7106-11 pubmed
    ..Although the anatomical expression patterns of the c-fos gene, a transcription factor-encoding immediate-early gene, in conditioned taste aversion (CTA) are well documented,..
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