Fn14

Summary

Gene Symbol: Fn14
Description: tumor necrosis factor receptor superfamily, member 12a
Alias: AI255180, C87282, Fn14, HPIP, TWEAK-R, TweakR, tumor necrosis factor receptor superfamily member 12A, FGF-inducible 14, fibroblast growth factor-inducible immediate-early response protein 14, fibroblast growth factor-regulated protein 2, tweak-receptor, type I transmembrane protein Fn14
Species: mouse
Products:     Fn14

Top Publications

  1. Feng S, Guo Y, Factor V, Thorgeirsson S, Bell D, Testa J, et al. The Fn14 immediate-early response gene is induced during liver regeneration and highly expressed in both human and murine hepatocellular carcinomas. Am J Pathol. 2000;156:1253-61 pubmed
    ..factor (FGF)-inducible genes in murine NIH 3T3 cells and recently reported that one of them, the FGF-inducible 14 (Fn14) immediate-early response gene, is predicted to encode a novel, cell surface-localized type Ia transmembrane ..
  2. Jain M, Jakubowski A, Cui L, Shi J, Su L, Bauer M, et al. A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure. Circulation. 2009;119:2058-68 pubmed publisher
    ..Herein, we demonstrate that mouse and human cardiomyocytes express the TWEAK receptor Fn14...
  3. Girgenrath M, Weng S, Kostek C, Browning B, Wang M, Brown S, et al. TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration. EMBO J. 2006;25:5826-39 pubmed
    ..By generating mice deficient in the TWEAK receptor Fn14, we further showed that Fn14-deficient primary myoblasts displayed significantly reduced proliferative ..
  4. Haile W, Echeverry R, Wu J, Yepes M. The interaction between tumor necrosis factor-like weak inducer of apoptosis and its receptor fibroblast growth factor-inducible 14 promotes the recruitment of neutrophils into the ischemic brain. J Cereb Blood Flow Metab. 2010;30:1147-56 pubmed publisher
    Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible 14 (Fn14) are expressed in endothelial cells and perivascular astrocytes...
  5. Bird T, Lu W, Boulter L, Gordon Keylock S, Ridgway R, Williams M, et al. Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling. Proc Natl Acad Sci U S A. 2013;110:6542-7 pubmed publisher
    ..Overall these results reveal a hitherto undescribed mechanism linking macrophage infiltration to DRs in the liver and highlight a rationale for macrophage derived cell therapy in regenerative medicine. ..
  6. Wiley S, Cassiano L, Lofton T, Davis Smith T, Winkles J, Lindner V, et al. A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity. 2001;15:837-46 pubmed
    ..We report cloning of a receptor for TWEAK (TweakR) from a human umbilical vein endothelial cell (HUVEC) library...
  7. Brown S, Richards C, Hanscom H, Feng S, Winkles J. The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation. Biochem J. 2003;371:395-403 pubmed
    ..These results indicate that Fn14 is a functional TWEAK receptor that can associate with four distinct TRAF family members and stimulate the NF-kappaB transcription factor ..
  8. Nakayama M, Harada N, Okumura K, Yagita H. Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies. Biochem Biophys Res Commun. 2003;306:819-25 pubmed
    In the present study, we characterized murine TWEAK and its receptor (Fn14) by generating cDNA transfectants and specific monoclonal antibodies (mAbs)...
  9. Tanabe K, Bonilla I, Winkles J, Strittmatter S. Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth. J Neurosci. 2003;23:9675-86 pubmed
    ..Induction of SOX11, FLRT3, myosin-X, and fibroblast growth factor-inducible-14 (Fn14) mRNA in axotomized DRG neurons was verified by Northern analysis and in situ hybridization...

More Information

Publications55

  1. Meighan Mantha R, Hsu D, Guo Y, Brown S, Feng S, Peifley K, et al. The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration. J Biol Chem. 1999;274:33166-76 pubmed
    ..Here, we report that the fibroblast growth factor-inducible-14 (Fn14) gene is a growth factor-regulated, immediate-early response gene expressed in a developmental stage- and adult ..
  2. Campbell S, Burkly L, Gao H, Berman J, Su L, Browning B, et al. Proinflammatory effects of TWEAK/Fn14 interactions in glomerular mesangial cells. J Immunol. 2006;176:1889-98 pubmed
    ..Ligation of the TWEAK receptor Fn14 by TWEAK has proinflammatory effects on fibroblasts, synoviocytes, and endothelial cells...
  3. Polek T, Talpaz M, Darnay B, Spivak Kroizman T. TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor. J Biol Chem. 2003;278:32317-23 pubmed
    ..We show that the Fn14/TWEAK receptor (TweakR) was not responsible for the osteoclastic effect of TWEAK on RAW cells...
  4. Dogra C, Hall S, Wedhas N, Linkhart T, Kumar A. Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis. J Biol Chem. 2007;282:15000-10 pubmed
    Fibroblast growth factor-inducible 14 (Fn14), distantly related to tumor necrosis factor receptor superfamily and a receptor for TWEAK cytokine, has been implicated in several biological responses...
  5. Zhao Z, Burkly L, Campbell S, Schwartz N, Molano A, Choudhury A, et al. TWEAK/Fn14 interactions are instrumental in the pathogenesis of nephritis in the chronic graft-versus-host model of systemic lupus erythematosus. J Immunol. 2007;179:7949-58 pubmed
    ..We previously found that kidney cells display the TWEAK receptor Fn14, and that TWEAK stimulation of mesangial cells and podocytes induces a potent proinflammatory response...
  6. Burkly L, Michaelson J, Hahm K, Jakubowski A, Zheng T. TWEAKing tissue remodeling by a multifunctional cytokine: role of TWEAK/Fn14 pathway in health and disease. Cytokine. 2007;40:1-16 pubmed
    ..cell responses in settings of acute injury through its highly inducible receptor, FGF-inducible molecule 14 (Fn14), establishing the pathway's physiological role in facilitating acute tissue repair...
  7. Jakubowski A, Ambrose C, Parr M, Lincecum J, Wang M, Zheng T, et al. TWEAK induces liver progenitor cell proliferation. J Clin Invest. 2005;115:2330-40 pubmed
    ..TWEAK (TNF-like weak inducer of apoptosis) stimulates oval cell proliferation in mouse liver through its receptor Fn14. TWEAK has no effect on mature hepatocytes and thus appears to be selective for oval cells...
  8. Haile W, Echeverry R, Wu F, Guzman J, An J, Wu J, et al. Tumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 mediate cerebral ischemia-induced poly(ADP-ribose) polymerase-1 activation and neuronal death. Neuroscience. 2010;171:1256-64 pubmed publisher
    Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor Fibroblast growth factor-inducible 14 (Fn14) are expressed in neurons...
  9. Hotta K, Sho M, Yamato I, Shimada K, Harada H, Akahori T, et al. Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury. Kidney Int. 2011;79:179-88 pubmed publisher
    ..The TWEAK receptor, fibroblast growth factor-inducible 14 (Fn14), has various unique functions under physiological and ..
  10. Wen J, Xia Y, Stock A, Michaelson J, Burkly L, Gulinello M, et al. Neuropsychiatric disease in murine lupus is dependent on the TWEAK/Fn14 pathway. J Autoimmun. 2013;43:44-54 pubmed publisher
    ..TWEAK is a TNF family ligand that mediates pleotropic effects through its receptor Fn14, including the stimulation of inflammatory cytokine production by astrocytes, endothelial cells, and other non-..
  11. Xia Y, Campbell S, Broder A, Herlitz L, Abadi M, Wu P, et al. Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis. Clin Immunol. 2012;145:108-21 pubmed publisher
    Previously it was shown that the TNF superfamily member TWEAK (TNFSF12) acts through its receptor, Fn14, to promote proinflammatory responses in kidney cells, including the production of MCP-1, RANTES, IP-10 and KC...
  12. Karaca G, Swiderska Syn M, Xie G, Syn W, Krüger L, Machado M, et al. TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice. PLoS ONE. 2014;9:e83987 pubmed publisher
    ..Expression of Fibroblast growth factor-inducible 14 (Fn14), the receptor for TNF-like weak inducer of apoptosis (TWEAK), is induced rapidly after PH and remains elevated ..
  13. Shi J, Jiang B, Qiu Y, Guan J, Jain M, Cao X, et al. PGC1? plays a critical role in TWEAK-induced cardiac dysfunction. PLoS ONE. 2013;8:e54054 pubmed publisher
    ..downregulation of PGC1? requires expression of its cell surface receptor, fibroblast growth factor-inducible 14 (Fn14)...
  14. Di Martino L, Dave M, Menghini P, Xin W, Arseneau K, Pizarro T, et al. Protective Role for TWEAK/Fn14 in Regulating Acute Intestinal Inflammation and Colitis-Associated Tumorigenesis. Cancer Res. 2016;76:6533-6542 pubmed publisher
    ..In particular, TNF-like weak inducer of apoptosis (TWEAK) and its receptor, Fn14, are involved in normal and pathologic intestinal tissue remodeling...
  15. Brown S, Hanscom H, Vu H, Brew S, Winkles J. TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules. Biochem J. 2006;397:297-304 pubmed
    ..TWEAK binds with high affinity to a single TNF receptor super-family member, Fn14 (fibroblast growth factor-inducible 14)...
  16. Doerner J, Chalmers S, Friedman A, Putterman C. Fn14 deficiency protects lupus-prone mice from histological lupus erythematosus-like skin inflammation induced by ultraviolet light. Exp Dermatol. 2016;25:969-976 pubmed publisher
    The cytokine TNF-like weak inducer of apoptosis (TWEAK) and its receptor Fn14 are involved in cell survival and cytokine production...
  17. Tajrishi M, Sato S, Shin J, Zheng T, Burkly L, Kumar A. The TWEAK-Fn14 dyad is involved in age-associated pathological changes in skeletal muscle. Biochem Biophys Res Commun. 2014;446:1219-1224 pubmed publisher
    ..Recently, proinflammatory cytokine TWEAK and its receptor Fn14 were identified as key mediators of muscle wasting in various catabolic states...
  18. Scholzke M, Röttinger A, Murikinati S, Gehrig N, Leib C, Schwaninger M. TWEAK regulates proliferation and differentiation of adult neural progenitor cells. Mol Cell Neurosci. 2011;46:325-32 pubmed publisher
    ..In adult mice deficient of the TWEAK receptor Fn14, neurogenesis was reduced in the subventricular zone...
  19. Fick A, Lang I, Schäfer V, Seher A, Trebing J, Weisenberger D, et al. Studies of binding of tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) to fibroblast growth factor inducible 14 (Fn14). J Biol Chem. 2012;287:484-95 pubmed publisher
    ..The dissociation rate constant of the TWEAK-Fn14 interaction was between 0.48×10(-3) s(-1) (HT29) and 0...
  20. Karaca G, Xie G, Moylan C, Swiderska Syn M, Guy C, Krüger L, et al. Role of Fn14 in acute alcoholic steatohepatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2015;308:G325-34 pubmed publisher
    ..is a growth factor for bipotent liver progenitors that express its receptor, fibroblast growth factor-inducible 14 (Fn14), a TNF receptor superfamily member...
  21. Wu F, Guo L, Jakubowski A, Su L, Li W, Bonner Weir S, et al. TNF-like weak inducer of apoptosis (TWEAK) promotes beta cell neogenesis from pancreatic ductal epithelium in adult mice. PLoS ONE. 2013;8:e72132 pubmed publisher
    ..regeneration was determined by pancytokeratin immunostaining of paraffin embedded sections from wildtype and TWEAK receptor (Fn14) deficient mice after Px...
  22. Molano A, Lakhani P, Aran A, Burkly L, Michaelson J, Putterman C. TWEAK stimulation of kidney resident cells in the pathogenesis of graft versus host induced lupus nephritis. Immunol Lett. 2009;125:119-28 pubmed publisher
    ..Recently, we have shown that interactions of TWEAK with its receptor Fn14 are instrumental in the pathogenesis of nephritis in the chronic graft-versus-host (cGVH) induced model of lupus...
  23. Yadava R, Foff E, Yu Q, Gladman J, Kim Y, Bhatt K, et al. TWEAK/Fn14, a pathway and novel therapeutic target in myotonic dystrophy. Hum Mol Genet. 2015;24:2035-48 pubmed publisher
    ..Currently, no therapies exist. Here, we identify that fibroblast growth factor-inducible 14 (Fn14), a member of the tumor necrosis factor receptor super-family, is induced in skeletal muscles and hearts of mouse ..
  24. Mittal A, Bhatnagar S, Kumar A, Lach Trifilieff E, Wauters S, Li H, et al. The TWEAK-Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice. J Cell Biol. 2010;188:833-49 pubmed publisher
    ..Expression of the TWEAK receptor Fn14 (fibroblast growth factor-inducible receptor 14) and not the cytokine is significantly increased in ..
  25. Ferry A, Joanne P, Hadj Saïd W, Vignaud A, Lilienbaum A, Hourde C, et al. Advances in the understanding of skeletal muscle weakness in murine models of diseases affecting nerve-evoked muscle activity, motor neurons, synapses and myofibers. Neuromuscul Disord. 2014;24:960-72 pubmed publisher
    ..Moreover, in SOD1 and Neurotomized mice our results suggest LC3, Fn14, Bcl3 and Gadd45a as candidate genes involved in the maintenance of the severe atrophic state...
  26. Ameri H, Liu H, Liu R, Ha Y, Paulucci Holthauzen A, Hu S, et al. TWEAK/Fn14 pathway is a novel mediator of retinal neovascularization. Invest Ophthalmol Vis Sci. 2014;55:801-13 pubmed publisher
    ..factor (TNF)-like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor inducible-14 (Fn14), have been implicated in angiogenesis, but their role in retinal diseases is unknown...
  27. Tajrishi M, Shin J, Hetman M, Kumar A. DNA methyltransferase 3a and mitogen-activated protein kinase signaling regulate the expression of fibroblast growth factor-inducible 14 (Fn14) during denervation-induced skeletal muscle atrophy. J Biol Chem. 2014;289:19985-99 pubmed publisher
    The TWEAK-fibroblast growth factor-inducible 14 (Fn14) system is a critical regulator of denervation-induced skeletal muscle atrophy...
  28. Hindi S, Mishra V, Bhatnagar S, Tajrishi M, Ogura Y, Yan Z, et al. Regulatory circuitry of TWEAK-Fn14 system and PGC-1? in skeletal muscle atrophy program. FASEB J. 2014;28:1398-411 pubmed publisher
    ..peroxisome proliferator-activated receptor ? coactivator 1? (PGC-1?) and TNF-like weak inducer of apoptosis (TWEAK)-Fn14 system are key regulators of skeletal muscle mass in various catabolic states...
  29. Prinz Hadad H, Mizrachi T, Irony Tur Sinai M, Prigozhina T, Aronin A, Brenner T, et al. Amelioration of autoimmune neuroinflammation by the fusion molecule Fn14·TRAIL. J Neuroinflammation. 2013;10:36 pubmed publisher
    ..The recently described fusion protein, Fn14·TRAIL, combining the extracellular domain of Fn14 (capable of blocking the pro-inflammatory TWEAK ligand) fused to ..
  30. Rayego Mateos S, Morgado Pascual J, Sanz A, Ramos A, Eguchi S, Batlle D, et al. TWEAK transactivation of the epidermal growth factor receptor mediates renal inflammation. J Pathol. 2013;231:480-94 pubmed publisher
    TWEAK, a member of the TNF superfamily, binds to the Fn14 receptor, eliciting biological responses. EGFR signalling is involved in experimental renal injury. Our aim was to investigate the relationship between TWEAK and EGFR in the kidney...
  31. Mustafa S, Martin H, Burkly L, Costa A, Martins M, Schwaninger M, et al. The role of TWEAK/Fn14 signaling in the MPTP-model of Parkinson's disease. Neuroscience. 2016;319:116-22 pubmed publisher
    ..necrosis factor like weak inducer of apoptosis (TWEAK) and its receptor, fibroblast growth factor-inducible 14 (Fn14), mediate inflammation and neuronal apoptosis in cerebral edema, ischemic stroke and multiple sclerosis...
  32. Gurunathan S, Winkles J, Ghosh S, Hayden M. Regulation of fibroblast growth factor-inducible 14 (Fn14) expression levels via ligand-independent lysosomal degradation. J Biol Chem. 2014;289:12976-88 pubmed publisher
    Fibroblast growth factor-inducible 14 (Fn14) is a highly inducible cytokine receptor that engages multiple intracellular signaling pathways, including nuclear factor-?B (NF-?B) and mitogen-activated protein kinase (MAPK)...
  33. Justo P, Sanz A, Sanchez Niño M, Winkles J, Lorz C, Egido J, et al. Cytokine cooperation in renal tubular cell injury: the role of TWEAK. Kidney Int. 2006;70:1750-8 pubmed
    ..TWEAK activates the Fn14 receptor, and may regulate apoptosis, proliferation, and inflammation, processes that play a significant role in ..
  34. Doerner J, Wen J, Xia Y, Paz K, Schairer D, Wu L, et al. TWEAK/Fn14 Signaling Involvement in the Pathogenesis of Cutaneous Disease in the MRL/lpr Model of Spontaneous Lupus. J Invest Dermatol. 2015;135:1986-1995 pubmed publisher
    Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK, TNFSF12) and its sole receptor Fn14, belonging to the TNF ligand and receptor superfamilies respectively, are involved in cell survival and cytokine production...
  35. Sanchez Nino M, Poveda J, Sanz A, Mezzano S, Carrasco S, Fernández Fernández B, et al. Fn14 in podocytes and proteinuric kidney disease. Biochim Biophys Acta. 2013;1832:2232-43 pubmed publisher
    ..We have now explored the regulation and role of TWEAK receptor Fn14 in mediating glomerular inflammation in cultured podocytes and in experimental and human non-immune ..
  36. Echeverry R, Wu F, Haile W, Wu J, Yepes M. The cytokine tumor necrosis factor-like weak inducer of apoptosis and its receptor fibroblast growth factor-inducible 14 have a neuroprotective effect in the central nervous system. J Neuroinflammation. 2012;9:45 pubmed publisher
    ..necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible 14 (Fn14) are found in neurons and their expression is induced by exposure to sub-lethal hypoxia...
  37. Matsui H, Fukuno N, Kanda Y, Kantoh Y, Chida T, Nagaura Y, et al. The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts. J Biol Chem. 2014;289:6438-50 pubmed publisher
    ..The activated JNK led to transiently enhanced expression of FGF-inducible 14 (Fn14, a member of the TNF receptor superfamily) gene...
  38. Dohi T, Borodovsky A, Wu P, Shearstone J, Kawashima R, Runkel L, et al. TWEAK/Fn14 pathway: a nonredundant role in intestinal damage in mice through a TWEAK/intestinal epithelial cell axis. Gastroenterology. 2009;136:912-23 pubmed publisher
    ..TNF family cytokine that signals through its receptor, fibroblast growth factor-inducible molecule 14 (Fn14). The role of this pathway in the intestine has not been previously reported...
  39. Son A, Oshio T, Kawamura Y, Hagiwara T, Yamazaki M, Inagaki Ohara K, et al. TWEAK/Fn14 pathway promotes a T helper 2-type chronic colitis with fibrosis in mice. Mucosal Immunol. 2013;6:1131-42 pubmed publisher
    ..member, induces damage of the epithelial cells (ECs) and production of inflammatory mediaters through its receptor Fn14 in a model of acute colitis...
  40. Novoyatleva T, Janssen W, Wietelmann A, Schermuly R, Engel F. TWEAK/Fn14 axis is a positive regulator of cardiac hypertrophy. Cytokine. 2013;64:43-5 pubmed publisher
    ..We recently identified Fn14 as an endogenous key regulator in cardiac fibrosis in the PAB (Pulmonary Artery Banding) pressure-overload model...
  41. Wen J, Doerner J, Weidenheim K, Xia Y, Stock A, Michaelson J, et al. TNF-like weak inducer of apoptosis promotes blood brain barrier disruption and increases neuronal cell death in MRL/lpr mice. J Autoimmun. 2015;60:40-50 pubmed publisher
    ..Furthermore, knockout (KO) of the TWEAK receptor, Fn14, in the MRL/lpr lupus mouse strain markedly attenuates neuropsychiatric disease, as demonstrated by ..
  42. Lu W, Bird T, Boulter L, Tsuchiya A, Cole A, Hay T, et al. Hepatic progenitor cells of biliary origin with liver repopulation capacity. Nat Cell Biol. 2015;17:971-983 pubmed publisher
    ..HPCs are therefore a potential future alternative to hepatocyte or liver transplantation for liver disease. ..
  43. Novoyatleva T, Schymura Y, Janssen W, Strobl F, Swiercz J, Patra C, et al. Deletion of Fn14 receptor protects from right heart fibrosis and dysfunction. Basic Res Cardiol. 2013;108:325 pubmed publisher
    ..Previously, the TNF receptor superfamily member fibroblast growth factor-inducible molecule 14 (Fn14) has been associated with different fibrotic diseases...
  44. Sezaki T, Hirata Y, Hagiwara T, Kawamura Y, Okamura T, Takanashi R, et al. Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice. World J Gastroenterol. 2017;23:2294-2307 pubmed publisher
    To clarify the roles of TWEAK and its receptor Fn14 in 5-fluorouracil (5-FU)-induced diarrhea. Diarrhea was induced in wild-type (WT), Fn14 knockout (KO), and IL-13 receptor (IL-13R)?1 KO BALB/c mice using a single injection of 5-FU...
  45. Hamill C, Michaelson J, Hahm K, Burkly L, Kessler J. Age-dependent effects of TWEAK/Fn14 receptor activation on neural progenitor cells. J Neurosci Res. 2007;85:3535-44 pubmed
    TWEAK/Fn14 signaling regulates progenitor cell proliferation, differentiation, and survival in multiple organ systems...
  46. Munoz Garcia B, Madrigal Matute J, Moreno J, Martin Ventura J, Lopez Franco O, Sastre C, et al. TWEAK-Fn14 interaction enhances plasminogen activator inhibitor 1 and tissue factor expression in atherosclerotic plaques and in cultured vascular smooth muscle cells. Cardiovasc Res. 2011;89:225-33 pubmed publisher
    ..member of the tumour necrosis factor superfamily that, through its receptor, fibroblast growth factor-inducible 14 (Fn14), participates in vascular remodelling, increasing vascular inflammatory responses and atherosclerotic lesion size ..