Fn1

Summary

Gene Symbol: Fn1
Description: fibronectin 1
Alias: E330027I09, Fn-1, fibronectin
Species: mouse
Products:     Fn1

Top Publications

  1. Georges Labouesse E, George E, Rayburn H, Hynes R. Mesodermal development in mouse embryos mutant for fibronectin. Dev Dyn. 1996;207:145-56 pubmed
    Three independent mutations were made by homologous recombination in two different regions of the fibronectin (FN) gene; all three appeared to be functional null mutations...
  2. Dallas S, Sivakumar P, Jones C, Chen Q, Peters D, Mosher D, et al. Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1. J Biol Chem. 2005;280:18871-80 pubmed
    ..Here we show that fibronectin is critical for the incorporation of LTBP1 and transforming growth factor-beta (TGF beta) into the ECM of ..
  3. Pulina M, Hou S, Mittal A, Jülich D, Whittaker C, Holley S, et al. Essential roles of fibronectin in the development of the left-right embryonic body plan. Dev Biol. 2011;354:208-20 pubmed publisher
    ..Taken together, our studies demonstrate the requisite role for a structural ECM protein and its integrin receptor in the development of the left-right axis of asymmetry in vertebrates. ..
  4. Liang X, Sun Y, Ye M, Scimia M, Cheng H, Martin J, et al. Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation. 2009;120:568-76 pubmed publisher
    ..These results demonstrate essential roles for PINCHs in myocardial growth, maturation, remodeling, and function and highlight the importance of studying the role of PINCHs in human cardiac injury and cardiomyopathy. ..
  5. Tang N, Mack F, Haase V, Simon M, Johnson R. pVHL function is essential for endothelial extracellular matrix deposition. Mol Cell Biol. 2006;26:2519-30 pubmed
    ..The defects in embryonic vascularization were correlated with a diminished vascular fibronectin deposition in vivo and defective endothelial extracellular fibronectin assembly in vitro...
  6. Takahashi S, Leiss M, Moser M, Ohashi T, Kitao T, Heckmann D, et al. The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol. 2007;178:167-78 pubmed
    b>Fibronectin (FN) is secreted as a disulfide-bonded FN dimer. Each subunit contains three types of repeating modules: FN-I, FN-II, and FN-III...
  7. Wendler C, Schmoldt A, Flentke G, Case L, Quadro L, Blaner W, et al. Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null mice. Circ Res. 2003;92:920-8 pubmed
    ..Most remarkably, RBP-null hearts display augmented deposition of fibronectin protein in the cardiac jelly at E9.0 through E10.5 and in the outflow tract at E12.5...
  8. Fontana L, Chen Y, Prijatelj P, Sakai T, Fassler R, Sakai L, et al. Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1. FASEB J. 2005;19:1798-808 pubmed
    ..The LTBP-1 polypeptide rL1N, which includes the hinge, associates with fibronectin in binding assays...
  9. Bader B, Rayburn H, Crowley D, Hynes R. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell. 1998;95:507-19 pubmed
    ..These results necessitate reevaluation of the primacy of alphav integrins in many functions including vascular development, despite reports that blockade of these integrins with antibodies or peptides prevents angiogenesis. ..
  10. Sengbusch J, He W, Pinco K, Yang J. Dual functions of [alpha]4[beta]1 integrin in epicardial development: initial migration and long-term attachment. J Cell Biol. 2002;157:873-82 pubmed
    ..T., H. Rayburn, and R.O. Hynes. 1995. Development. 121:549-560). ..

Detail Information

Publications72

  1. Georges Labouesse E, George E, Rayburn H, Hynes R. Mesodermal development in mouse embryos mutant for fibronectin. Dev Dyn. 1996;207:145-56 pubmed
    Three independent mutations were made by homologous recombination in two different regions of the fibronectin (FN) gene; all three appeared to be functional null mutations...
  2. Dallas S, Sivakumar P, Jones C, Chen Q, Peters D, Mosher D, et al. Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1. J Biol Chem. 2005;280:18871-80 pubmed
    ..Here we show that fibronectin is critical for the incorporation of LTBP1 and transforming growth factor-beta (TGF beta) into the ECM of ..
  3. Pulina M, Hou S, Mittal A, Jülich D, Whittaker C, Holley S, et al. Essential roles of fibronectin in the development of the left-right embryonic body plan. Dev Biol. 2011;354:208-20 pubmed publisher
    ..Taken together, our studies demonstrate the requisite role for a structural ECM protein and its integrin receptor in the development of the left-right axis of asymmetry in vertebrates. ..
  4. Liang X, Sun Y, Ye M, Scimia M, Cheng H, Martin J, et al. Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation. 2009;120:568-76 pubmed publisher
    ..These results demonstrate essential roles for PINCHs in myocardial growth, maturation, remodeling, and function and highlight the importance of studying the role of PINCHs in human cardiac injury and cardiomyopathy. ..
  5. Tang N, Mack F, Haase V, Simon M, Johnson R. pVHL function is essential for endothelial extracellular matrix deposition. Mol Cell Biol. 2006;26:2519-30 pubmed
    ..The defects in embryonic vascularization were correlated with a diminished vascular fibronectin deposition in vivo and defective endothelial extracellular fibronectin assembly in vitro...
  6. Takahashi S, Leiss M, Moser M, Ohashi T, Kitao T, Heckmann D, et al. The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. J Cell Biol. 2007;178:167-78 pubmed
    b>Fibronectin (FN) is secreted as a disulfide-bonded FN dimer. Each subunit contains three types of repeating modules: FN-I, FN-II, and FN-III...
  7. Wendler C, Schmoldt A, Flentke G, Case L, Quadro L, Blaner W, et al. Increased fibronectin deposition in embryonic hearts of retinol-binding protein-null mice. Circ Res. 2003;92:920-8 pubmed
    ..Most remarkably, RBP-null hearts display augmented deposition of fibronectin protein in the cardiac jelly at E9.0 through E10.5 and in the outflow tract at E12.5...
  8. Fontana L, Chen Y, Prijatelj P, Sakai T, Fassler R, Sakai L, et al. Fibronectin is required for integrin alphavbeta6-mediated activation of latent TGF-beta complexes containing LTBP-1. FASEB J. 2005;19:1798-808 pubmed
    ..The LTBP-1 polypeptide rL1N, which includes the hinge, associates with fibronectin in binding assays...
  9. Bader B, Rayburn H, Crowley D, Hynes R. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. Cell. 1998;95:507-19 pubmed
    ..These results necessitate reevaluation of the primacy of alphav integrins in many functions including vascular development, despite reports that blockade of these integrins with antibodies or peptides prevents angiogenesis. ..
  10. Sengbusch J, He W, Pinco K, Yang J. Dual functions of [alpha]4[beta]1 integrin in epicardial development: initial migration and long-term attachment. J Cell Biol. 2002;157:873-82 pubmed
    ..T., H. Rayburn, and R.O. Hynes. 1995. Development. 121:549-560). ..
  11. Curnis F, Longhi R, Crippa L, Cattaneo A, Dondossola E, Bachi A, et al. Spontaneous formation of L-isoaspartate and gain of function in fibronectin. J Biol Chem. 2006;281:36466-76 pubmed
    ..In particular, we show that deamidation of Asn263 at the Asn-Gly-Arg (NGR) site in fibronectin N-terminal region generates an alpha(v)beta3-integrin binding site containing the L-isoDGR sequence, which is ..
  12. Kawelke N, Vasel M, Sens C, Au A, Dooley S, Nakchbandi I. Fibronectin protects from excessive liver fibrosis by modulating the availability of and responsiveness of stellate cells to active TGF-?. PLoS ONE. 2011;6:e28181 pubmed publisher
    Fibrotic tissue in the liver is mainly composed of collagen. Fibronectin, which is also present in fibrotic matrices, is required for collagen matrix assembly in vitro...
  13. George E, Georges Labouesse E, Patel King R, Rayburn H, Hynes R. Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development. 1993;119:1079-91 pubmed
    To examine the role of fibronectin in vivo, we have generated mice in which the fibronectin gene is inactivated. Heterozygotes have one half normal levels of plasma fibronectin, yet appear normal...
  14. Jiang G, Giannone G, Critchley D, Fukumoto E, Sheetz M. Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin. Nature. 2003;424:334-7 pubmed
    ..The minimal matrix complex causing integrin-cytoskeleton connections is a trimer of fibronectin's integrin-binding domain FNIII7-10 (ref. 4)...
  15. van der Flier A, Badu Nkansah K, Whittaker C, Crowley D, Bronson R, Lacy Hulbert A, et al. Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development. Development. 2010;137:2439-49 pubmed publisher
    Integrin cell adhesion receptors and fibronectin, one of their extracellular matrix ligands, have been demonstrated to be important for angiogenesis using functional perturbation studies and complete knockout mouse models...
  16. George E, Baldwin H, Hynes R. Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells. Blood. 1997;90:3073-81 pubmed
    The underlying mechanisms of lethal cardiovascular defects associated with the fibronectin-null (FN.null) mutation in mouse embryos were investigated by lineage analysis of myocardial, endocardial, and endothelial cells...
  17. Hocking D, Chang C. Fibronectin matrix polymerization regulates small airway epithelial cell migration. Am J Physiol Lung Cell Mol Physiol. 2003;285:L169-79 pubmed
    The continuous conversion of soluble fibronectin into extracellular matrix fibrils occurs through a dynamic, cell-dependent process...
  18. Molin D, Poelmann R, DeRuiter M, Azhar M, Doetschman T, Gittenberger de Groot A. Transforming growth factor beta-SMAD2 signaling regulates aortic arch innervation and development. Circ Res. 2004;95:1109-17 pubmed
    ..For diminished transforming growth factor beta (TGF-beta) signaling, SMAD2 and fibronectin have been analyzed...
  19. Aufderheide E, Ekblom P. Tenascin during gut development: appearance in the mesenchyme, shift in molecular forms, and dependence on epithelial-mesenchymal interactions. J Cell Biol. 1988;107:2341-9 pubmed
    ..We propose that growing and differentiating epithelia produce locally active factors which stimulate synthesis of tenascin in the surrounding mesenchyme. ..
  20. d Amaro R, Scheidegger R, Blumer S, Pazera P, Katsaros C, Graf D, et al. Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis. Front Physiol. 2012;3:377 pubmed publisher
    ..These provide substrates for cell adhesion (e.g., fibronectin, tenascins), but also regulate growth factor availability (e.g., fibrillins)...
  21. Moretti F, Chauhan A, Iaconcig A, Porro F, Baralle F, Muro A. A major fraction of fibronectin present in the extracellular matrix of tissues is plasma-derived. J Biol Chem. 2007;282:28057-62 pubmed
    The origin of the fibronectin (FN) found in the extracellular matrix of tissues has not been defined experimentally...
  22. Sakai T, Johnson K, Murozono M, Sakai K, Magnuson M, Wieloch T, et al. Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. Nat Med. 2001;7:324-30 pubmed
    b>Fibronectin performs essential roles in embryonic development and is prominently expressed during tissue repair...
  23. Bentmann A, Kawelke N, Moss D, Zentgraf H, Bala Y, Berger I, et al. Circulating fibronectin affects bone matrix, whereas osteoblast fibronectin modulates osteoblast function. J Bone Miner Res. 2010;25:706-15 pubmed publisher
    The bone matrix is composed mostly of collagen, but the initial and continuous presence of fibronectin was found to be crucial for collagen matrix integrity in vitro...
  24. Huveneers S, Truong H, Fassler R, Sonnenberg A, Danen E. Binding of soluble fibronectin to integrin alpha5 beta1 - link to focal adhesion redistribution and contractile shape. J Cell Sci. 2008;121:2452-62 pubmed publisher
    ..Extensive remodeling of adhesions in fibroblasts also takes part in fibronectin fibrillogenesis, a process that depends on Rho-mediated contractility and results in the formation of a ..
  25. Fukuda T, Yoshida N, Kataoka Y, Manabe R, Mizuno Horikawa Y, Sato M, et al. Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro. Cancer Res. 2002;62:5603-10 pubmed
    ..These results indicate that expression of EDB-containing isoforms is dispensable during embryonic development, yet may play a modulating role in the growth of connective tissue cells via the FN matrix. ..
  26. Ni H, Yuen P, Papalia J, Trevithick J, Sakai T, Fassler R, et al. Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Proc Natl Acad Sci U S A. 2003;100:2415-9 pubmed
    ..The platelets of these animals accumulate excessive amounts of fibronectin (FN). These observations led us to examine the contribution of plasma FN (pFN) to thrombus formation...
  27. Mittal A, Pulina M, Hou S, Astrof S. Fibronectin and integrin alpha 5 play essential roles in the development of the cardiac neural crest. Mech Dev. 2010;127:472-84 pubmed publisher
    ..b>Fibronectin (FN) protein is present along neural crest migration paths and neural crest cells migrate when plated on FN in ..
  28. Singh G, Johnston J, Ma W, Lozanoff S. Cleft palate formation in fetal Br mice with midfacial retrusion: tenascin, fibronectin, laminin, and type IV collagen immunolocalization. Cleft Palate Craniofac J. 1998;35:65-76 pubmed
    ..altered craniofacial morphology does not affect the expression of extracellular matrix (ECM) molecules such as fibronectin (FN), laminin (LN), type IV collagen, and tenascin-C (TN) but is associated with failure of palatal shelf ..
  29. Arslan F, Smeets M, Riem Vis P, Karper J, Quax P, Bongartz L, et al. Lack of fibronectin-EDA promotes survival and prevents adverse remodeling and heart function deterioration after myocardial infarction. Circ Res. 2011;108:582-92 pubmed publisher
    ..The extracellular matrix protein fibronectin-EDA (EIIIA; EDA) is upregulated after tissue injury and may act as a "danger signal" for leukocytes ..
  30. Ohsaki Y, Nagata K, Kurisu K. Localization of types I and III collagen and fibronectin in the developing mouse palatal shelves. Acta Anat (Basel). 1995;153:161-7 pubmed
    The detailed distribution of types I and III collagen and fibronectin was studied in the developing mouse palatal shelf using a double immunofluorescence technique...
  31. ffrench Constant C. Alternative splicing of fibronectin--many different proteins but few different functions. Exp Cell Res. 1995;221:261-71 pubmed
  32. Taverna D, Ullman Cullere M, Rayburn H, Bronson R, Hynes R. A test of the role of alpha5 integrin/fibronectin interactions in tumorigenesis. Cancer Res. 1998;58:848-53 pubmed
    Published data show that reduction or loss of fibronectin or its receptor, alpha5beta1 integrin, occurs frequently in tumors and transformed cells...
  33. Yang J, Bader B, Kreidberg J, Ullman Cullere M, Trevithick J, Hynes R. Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development. Dev Biol. 1999;215:264-77 pubmed
    Mouse embryos deficient in fibronectin (FN-null) die at E8.5 with mesodermal defects. Eight integrin heterodimers alpha3beta1, alpha4beta1, alpha5beta1, alpha8beta1, alphavbeta1, alphavbeta3, alphavbeta6, and alphaIIbbeta3 can bind to FN...
  34. Hocking D, Kowalski K. A cryptic fragment from fibronectin's III1 module localizes to lipid rafts and stimulates cell growth and contractility. J Cell Biol. 2002;158:175-84 pubmed
    The interaction of cells with the extracellular matrix (ECM) form of fibronectin (FN) triggers changes in growth, migration, and cytoskeletal organization that differ from those generated by soluble FN...
  35. Kinsey R, Williamson M, Chaudhry S, Mellody K, McGovern A, Takahashi S, et al. Fibrillin-1 microfibril deposition is dependent on fibronectin assembly. J Cell Sci. 2008;121:2696-704 pubmed publisher
    Newly deposited microfibrils strongly colocalise with fibronectin in primary fibroblasts. Microfibril formation is grossly inhibited by fibronectin depletion, but rescued by supplementation with exogenous cellular fibronectin...
  36. Monkley S, Zhou X, Kinston S, Giblett S, Hemmings L, Priddle H, et al. Disruption of the talin gene arrests mouse development at the gastrulation stage. Dev Dyn. 2000;219:560-74 pubmed
    ..Spreading of trophoblast cells derived from cultured mutant blastocysts on fibronectin and laminin is also considerably reduced...
  37. Muro A, Iaconcig A, Baralle F. Regulation of the fibronectin EDA exon alternative splicing. Cooperative role of the exonic enhancer element and the 5' splicing site. FEBS Lett. 1998;437:137-41 pubmed
    ..The EDA exon of the fibronectin gene is a typical example of an exon bearing a purine-rich exon splicing enhancer (ESE) element recognised by ..
  38. Astrof S, Crowley D, George E, Fukuda T, Sekiguchi K, Hanahan D, et al. Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis. Mol Cell Biol. 2004;24:8662-70 pubmed
    b>Fibronectin splice variants containing the EIIIA and/or EIIIB exons are prominently expressed in the vasculature of a variety of human tumors but not in normal adult tissues...
  39. von Au A, Vasel M, Kraft S, Sens C, Hackl N, Marx A, et al. Circulating fibronectin controls tumor growth. Neoplasia. 2013;15:925-38 pubmed
    b>Fibronectin is ubiquitously expressed in the extracellular matrix, and experimental evidence has shown that it modulates blood vessel formation...
  40. Peters J, Hynes R. Fibronectin isoform distribution in the mouse. I. The alternatively spliced EIIIB, EIIIA, and V segments show widespread codistribution in the developing mouse embryo. Cell Adhes Commun. 1996;4:103-25 pubmed
    ..Conversely, these segments would appear to play divergent, and sometimes exclusive, biological roles in specific tissues such as liver, cartilage, and placenta. ..
  41. Tan M, Sun Z, Opitz S, Schmidt T, Peters J, George E. Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosis. Blood. 2004;104:11-8 pubmed
    The alternatively spliced and highly conserved EIIIA domain of fibronectin (FN) is included in most FN of the extracellular matrix in embryos. In adults, both extracellular matrix and plasma FN essentially lack EIIIA...
  42. Arthur H, Ure J, Smith A, Renforth G, Wilson D, Torsney E, et al. Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. Dev Biol. 2000;217:42-53 pubmed
    ..We anticipate that heterozygous mice will ultimately serve as a useful disease model for HHT1, as some individuals have dilated and fragile blood vessels similar to vascular malformations seen in HHT patients. ..
  43. Yang J, Rayburn H, Hynes R. Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development. 1995;121:549-60 pubmed
    ..cell surface receptors that mediate cell-extracellular matrix (ECM) and cell-cell adhesions by interacting with fibronectin (FN) and vascular cell adhesion molecule 1 (VCAM-1), respectively...
  44. Yang J, Rayburn H, Hynes R. Embryonic mesodermal defects in alpha 5 integrin-deficient mice. Development. 1993;119:1093-105 pubmed
    ..However, the embryos progress significantly further than embryos null for fibronectin, for which alpha 5 beta 1 integrin is a receptor, suggesting the involvement of other fibronectin receptors...
  45. Turlo K, Noel O, Vora R, Larussa M, Fassler R, Hall Glenn F, et al. An essential requirement for ?1 integrin in the assembly of extracellular matrix proteins within the vascular wall. Dev Biol. 2012;365:23-35 pubmed publisher
    ..It further establishes a critical role of ?1 integrin in the protection against aneurysms that is particularly confined to the ascending aorta and its branches. ..
  46. Moriya K, Bae E, Honda K, Sakai K, Sakaguchi T, Tsujimoto I, et al. A fibronectin-independent mechanism of collagen fibrillogenesis in adult liver remodeling. Gastroenterology. 2011;140:1653-63 pubmed publisher
    ..Although it has been proposed that collagen organization and assembly depend on the fibronectin matrix in culture, the contribution of fibronectin to these processes remains to be defined in vivo...
  47. Saga Y, Yagi T, Ikawa Y, Sakakura T, Aizawa S. Mice develop normally without tenascin. Genes Dev. 1992;6:1821-31 pubmed
    ..histological abnormalities were detected in any tissues, and no major changes were observed in distribution of fibronectin, laminin, collagen, and proteoglycan...
  48. Martínez Sanz E, Del Río A, Barrio C, Murillo J, Maldonado E, Garcillán B, et al. Alteration of medial-edge epithelium cell adhesion in two Tgf-beta3 null mouse strains. Differentiation. 2008;76:417-30 pubmed
    ..We have performed immunohistochemistry with antibodies against collagens IV and IX, laminin, fibronectin, the alpha5- and beta1-integrins, and ICAM-1; in situ hybridization with a Nectin-1 riboprobe; and palatal ..
  49. Azhar M, Runyan R, Gard C, Sanford L, Miller M, Andringa A, et al. Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development. Dev Dyn. 2009;238:431-42 pubmed publisher
    ..5 with elevated levels of well-validated indicators of EMT. Collectively, these data indicate that TGFbeta2, and not TGFbeta1 or TGFbeta3, mediates cardiac cushion EMT by promoting both the initiation and cessation of EMT. ..
  50. Linton J, Martin G, Reichardt L. The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression. Development. 2007;134:2501-9 pubmed
    ..Our results thus place nephronectin and alpha8beta1 integrin in a pathway that regulates Gdnf expression and is essential for kidney development. ..
  51. Oh J, Takahashi R, Kondo S, Mizoguchi A, Adachi E, Sasahara R, et al. The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell. 2001;107:789-800 pubmed
    ..These results support a role for RECK in the regulation of MMP-2 in vivo and implicate RECK downregulation in tumor angiogenesis. ..
  52. Huang G, Zhang Y, Kim B, Ge G, Annis D, Mosher D, et al. Fibronectin binds and enhances the activity of bone morphogenetic protein 1. J Biol Chem. 2009;284:25879-88 pubmed publisher
    ..Such processing includes proteolytic activation of the zymogen for lysyl oxidase. Fibronectin (FN) is an abundant protein component of the ECM that is capable of regulating manifold cellular functions ..
  53. White R, Geissler E, Adkison L, Dowler L, Alper S, Lux S. Chromosomal location of the murine anion exchanger genes encoding AE2 and AE3. Mamm Genome. 1994;5:827-9 pubmed
  54. Kou K, James P, Clemmons D, Copeland N, Gilbert D, Jenkins N, et al. Identification of two clusters of mouse insulin-like growth factor binding protein genes on chromosomes 1 and 11. Genomics. 1994;21:653-5 pubmed
    ..These results suggest an evolutionary scheme in which a primordial IGFBP gene duplicated to form a cluster that was later replicated to create second linkage group. ..
  55. Collin G, Hubmacher D, Charette J, Hicks W, Stone L, Yu M, et al. Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation. Hum Mol Genet. 2015;24:6958-74 pubmed publisher
    ..In summary, the Adamtsl4(tvrm267) model provides a valuable tool to further elucidate the molecular basis of zonule formation, the pathophysiology of EL and ADAMTSL4 function in the maintenance of the RPE. ..
  56. CARLSON E, Magid R, Petryk A, Georgieff M. Iron deficiency alters expression of genes implicated in Alzheimer disease pathogenesis. Brain Res. 2008;1237:75-83 pubmed publisher
    ..Quantitative PCR confirmed altered regulation in 6 of 7 Alzheimer-related genes (Apbb1, C1qa, Clu, App, Cst3, Fn1, Htatip) in iron-deficient rats relative to iron-sufficient controls at P15...
  57. Whitesides J, LaMantia A. Distinct adhesive behaviors of neurons and neural precursor cells during regional differentiation in the mammalian forebrain. Dev Biol. 1995;169:229-41 pubmed
    ..These differences are transient and can only be detected in the telencephalic vesicle before and during the morphogenesis of rudiments of major forebrain subdivisions. ..
  58. Tenin G, Clowes C, Wolton K, Krejci E, Wright J, Lovell S, et al. Erbb2 is required for cardiac atrial electrical activity during development. PLoS ONE. 2014;9:e107041 pubmed publisher
    ..Thus, the l11Jus8 mouse reveals a novel function of Erbb2 during atrial conduction system development, which when disrupted causes death at mid-gestation. ..
  59. Xiao Z, Patrakka J, Nukui M, Chi L, Niu D, Betsholtz C, et al. Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice. Dev Dyn. 2011;240:2646-56 pubmed publisher
    ..5. These findings therefore indicate a novel role for the Crumbs family of proteins. ..
  60. de Almeida P, Pinheiro G, Nunes A, Gonçalves A, Thorsteinsdóttir S. Fibronectin assembly during early embryo development: A versatile communication system between cells and tissues. Dev Dyn. 2016;245:520-35 pubmed publisher
    b>Fibronectin extracellular matrix is essential for embryogenesis...
  61. Pratt S, Epple H, Ward M, Feng Y, Braga V, Longmore G. The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J Cell Biol. 2005;168:813-24 pubmed
  62. Uemura A, Kusuhara S, Wiegand S, Yu R, Nishikawa S. Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes. J Clin Invest. 2006;116:369-77 pubmed
    ..nuclear receptor tailless (Tlx) is strongly expressed in the proangiogenic astrocytes, which secrete VEGF and fibronectin. Tlx expression by retinal astrocytes is controlled by oxygen concentration and rapidly downregulated upon ..
  63. Chaen T, Konno T, Egashira M, Bai R, Nomura N, Nomura S, et al. Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence. PLoS ONE. 2012;7:e48933 pubmed publisher
    ..These findings define for the first time specific regulatory components of an estrogen-dependent pathway coordinating blastocyst adhesion competence and uterine receptivity...
  64. Brunner M, Millon Fremillon A, Chevalier G, Nakchbandi I, Mosher D, Block M, et al. Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin deposition. J Cell Biol. 2011;194:307-22 pubmed publisher
    ..Deposition of fibronectin and maturation of fibrillar adhesions, adhesive structures that accompany fibronectin deposition, are impaired ..
  65. Phelan S, Ito M, Loeken M. Neural tube defects in embryos of diabetic mice: role of the Pax-3 gene and apoptosis. Diabetes. 1997;46:1189-97 pubmed
    ..This pathway may be responsible for many of the neural tube defects resulting from diabetic pregnancy. ..
  66. Kenny H, Chiang C, White E, Schryver E, Habis M, Romero I, et al. Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion. J Clin Invest. 2014;124:4614-28 pubmed publisher
    ..Here, using organotypic 3D cultures, we found that primary human mesothelial cells secrete fibronectin in the presence of OvCa cells...
  67. Murphy P, Begum S, Hynes R. Tumor angiogenesis in the absence of fibronectin or its cognate integrin receptors. PLoS ONE. 2015;10:e0120872 pubmed publisher
    Binding of α5β1 and αvβ3/β5 integrin receptors on the endothelium to their fibronectin substrate in the extracellular matrix has been targeted as a possible means of blocking tumor angiogenesis and tumor growth...
  68. Ikeya M, Fukushima K, Kawada M, Onishi S, Furuta Y, Yonemura S, et al. Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors. Dev Biol. 2010;337:405-14 pubmed publisher
    ..These findings revealed the molecular hierarchy between extracellular modifiers that orchestrate local BMP signal peaks in the organogenetic microenvironment. ..
  69. Zhang C, Wu M, Zhang L, Shang L, Fang J, Zhuang S. Fibrotic microenvironment promotes the metastatic seeding of tumor cells via activating the fibronectin 1/secreted phosphoprotein 1-integrin signaling. Oncotarget. 2016;7:45702-45714 pubmed publisher
    ..Subsequent investigations revealed that the levels of fibronectin 1 (FN1) and secreted phosphoprotein 1 (SPP1) were significantly increased in fibrotic lungs...
  70. Kutsuna T, Inoue H, Takeda H, Takahashi T, Yamamoto H, Miura H, et al. Fibronectin regulates proteoglycan production balance in transforming growth factor-?1-induced chondrogenesis. Int J Mol Med. 2011;28:829-34 pubmed publisher
    ..The results of our recent study show that TGF-?1, but not BMP-4, strongly induces an ECM gene, fibronectin, during chondrogenesis. However, the role of fibronectin in chondrogenesis is unclear...
  71. Aso S, Baba R, Noda S, Ikuno S, Fujita M. Hypoplastic basement membrane of the lens anlage in the inheritable lens aplastic mouse (lap mouse). Teratology. 2000;61:262-72 pubmed
    ..light microscopy using antibodies against basement membrane components of the lens anlage, type IV collagen, fibronectin, laminin, heparan sulfate proteoglycan, and entactin and by transmission electron microscopy...
  72. Tchougounova E, Forsberg E, Angelborg G, Kjellen L, Pejler G. Altered processing of fibronectin in mice lacking heparin. a role for heparin-dependent mast cell chymase in fibronectin degradation. J Biol Chem. 2001;276:3772-7 pubmed
    ..Peptide microsequencing revealed identity of this protein with fibronectin. Western blot analysis showed the presence of fibronectin degradation products in cell cultures from normal ..