Fms interacting protein


Gene Symbol: Fms interacting protein
Description: THO complex 5
Alias: 1700060C24Rik, A430085L24Rik, Fmip, PK1.3, Sgk2, THO complex subunit 5 homolog, Fms interacting protein, fms-interacting protein, serum/glucocorticoid regulated kinase 2
Species: mouse
Products:     Fms interacting protein

Top Publications

  1. Mancini A, El Bounkari O, Norrenbrock A, Scherr M, Schaefer D, Eder M, et al. FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha. Oncogene. 2007;26:1020-7 pubmed
    b>Fms interacting protein (FMIP) is a substrate for Fms tyrosine kinase, and a nuclear/cytoplasm shuttling protein with a leucine zipper...
  2. Tamura T, Mancini A, Joos H, Koch A, Hakim C, Dumanski J, et al. FMIP, a novel Fms-interacting protein, affects granulocyte/macrophage differentiation. Oncogene. 1999;18:6488-95 pubmed
    ..Here we identified a novel Fms-interacting protein (FMIP, MW 78 kDa) which binds transiently via its N-terminal 144 residues to the cytoplasmic domain of activated Fms-..
  3. Mancini A, Koch A, Whetton A, Tamura T. The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation. Oncogene. 2004;23:6581-9 pubmed
    ..We have recently identified an Fms-interacting protein (FMIP) that binds transiently to the cytoplasmic domain of activated Fms molecules and is phosphorylated on tyrosine by ..
  4. Guria A, Tran D, Ramachandran S, Koch A, El Bounkari O, Dutta P, et al. Identification of mRNAs that are spliced but not exported to the cytoplasm in the absence of THOC5 in mouse embryo fibroblasts. RNA. 2011;17:1048-56 pubmed publisher
    ..Our previous study using conditional THOC5 (or FMIP) knockout mice revealed that the presence of THOC5 is critical in hematopoietic cells but not for terminally ..
  5. Tran D, Saran S, Dittrich Breiholz O, Williamson A, Klebba Färber S, Koch A, et al. Transcriptional regulation of immediate-early gene response by THOC5, a member of mRNA export complex, contributes to the M-CSF-induced macrophage differentiation. Cell Death Dis. 2013;4:e879 pubmed publisher
    ..In conclusion, regulation of immediate-early gene response by THOC5, a member of mRNA export complex contributes to the M-CSF-induced macrophage differentiation. ..
  6. Mancini A, Niemann Seyde S, Pankow R, El Bounkari O, Klebba Färber S, Koch A, et al. THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. BMC Biol. 2010;8:1 pubmed publisher
    ..FMIP(Fms interacting protein) is a member of the THO (suppressors of the transcriptional defects of hpr1delta by overexpression) ..
  7. Saran S, Tran D, Klebba Färber S, Morán Losada P, Wiehlmann L, Koch A, et al. THOC5, a member of the mRNA export complex, contributes to processing of a subset of wingless/integrated (Wnt) target mRNAs and integrity of the gut epithelial barrier. BMC Cell Biol. 2013;14:51 pubmed publisher
    ..These data imply that THOC5 may be a useful tool for studying intestinal stem cells, for modifying the differentiation processes and for cancer therapy. ..
  8. Wang L, Miao Y, Zheng X, Lackford B, Zhou B, Han L, et al. The THO complex regulates pluripotency gene mRNA export and controls embryonic stem cell self-renewal and somatic cell reprogramming. Cell Stem Cell. 2013;13:676-90 pubmed publisher
  9. Sakuma T, Tonne J, Ikeda Y. Murine leukemia virus uses TREX components for efficient nuclear export of unspliced viral transcripts. Viruses. 2014;6:1135-48 pubmed publisher
    ..Given that naturally intronless mRNAs, but not bulk mRNAs, require THOC5 for nuclear export, it is plausible that THOC5 plays a key role in the export of unspliced MLV transcripts. ..

More Information


  1. Klein A, Ferreira N, Ben Dor S, Duan J, Hardy J, Cox T, et al. Identification of Modifier Genes in a Mouse Model of Gaucher Disease. Cell Rep. 2016;16:2546-2553 pubmed publisher
    ..Our data identify putative modifier genes that may be involved in determining GD severity, which might help elucidate phenotypic variability between patients with similar GD mutations. ..