Flna

Summary

Gene Symbol: Flna
Description: filamin, alpha
Alias: ABP-280, Dilp2, F730004A14Rik, Fln1, GENA 379, filamin-1, filamin-A, actin-binding protein 280, dilated pupils 2, endothelial actin-binding protein, non-muscle filamin
Species: mouse
Products:     Flna

Top Publications

  1. Nakamura F, Stossel T, Hartwig J. The filamins: organizers of cell structure and function. Cell Adh Migr. 2011;5:160-9 pubmed
    b>Filamin A (FLNa), the first non-muscle actin filament cross-linking protein, was identified in 1975...
  2. Chiang W, Greaser M, Lyons G. Filamin isogene expression during mouse myogenesis. Dev Dyn. 2000;217:99-108 pubmed
    ..This is the first study of filamin gene expression at the early stages of skeletal muscle development. Dev Dyn 2000;217:99-108. ..
  3. Sampson L, Leyland M, Dart C. Direct interaction between the actin-binding protein filamin-A and the inwardly rectifying potassium channel, Kir2.1. J Biol Chem. 2003;278:41988-97 pubmed
    ..We conclude that filamin-A is potentially an important regulator of Kir2.1 surface expression and location within vascular smooth muscle. ..
  4. Liu G, Thomas L, Warren R, Enns C, Cunningham C, Hartwig J, et al. Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway. J Cell Biol. 1997;139:1719-33 pubmed
    ..The novel roles of ABP-280 and the cytoskeleton in the sorting of furin in the TGN/ endosomal system and the formation of proprotein processing compartments are discussed. ..
  5. Hart A, Morgan J, Schneider J, West K, McKie L, Bhattacharya S, et al. Cardiac malformations and midline skeletal defects in mice lacking filamin A. Hum Mol Genet. 2006;15:2457-67 pubmed
    The X-linked gene filamin A (Flna) encodes a widely expressed actin-binding protein that crosslinks actin into orthogonal networks and interacts with a variety of other proteins including membrane proteins, integrins, transmembrane ..
  6. Feng Y, Chen M, Moskowitz I, Mendonza A, Vidali L, Nakamura F, et al. Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Natl Acad Sci U S A. 2006;103:19836-41 pubmed
    Mutations in the human Filamin A (FLNA) gene disrupt neuronal migration to the cerebral cortex and cause cardiovascular defects...
  7. Lynch C, Gauthier N, Biais N, Lazar A, Roca Cusachs P, Yu C, et al. Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions. Mol Biol Cell. 2011;22:1263-73 pubmed publisher
    ..Indeed, shRNA-mediated knockdown of FlnA in FlnB(-/-) mouse embryonic fibroblasts (MEFs) causes a novel endoplasmic spreading deficiency as detected by ..
  8. Kanaji T, Russell S, Ware J. Amelioration of the macrothrombocytopenia associated with the murine Bernard-Soulier syndrome. Blood. 2002;100:2102-7 pubmed
    ..These results provide in vivo insights into the structural elements of the GP Ibalpha subunit that contribute to normal megakaryocyte maturation and thrombopoiesis. ..
  9. Sverdlov M, Shinin V, Place A, Castellon M, Minshall R. Filamin A regulates caveolae internalization and trafficking in endothelial cells. Mol Biol Cell. 2009;20:4531-40 pubmed publisher
    ..In the present study, we test the hypothesis that interactions between F-actin cross-linking protein filamin A and caveolin-1 facilitate the internalization and trafficking of caveolae...

More Information

Publications79

  1. Zhou X, Tian F, Sandzén J, Cao R, Flaberg E, Szekely L, et al. Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development. Proc Natl Acad Sci U S A. 2007;104:3919-24 pubmed
    ..These mice died or had to be euthanized before 4 weeks of age. Thus, the phenotypes of Flnb-deficient mice closely resemble those of human skeletal disorders with mutations in FLNB. ..
  2. Rivella S, Tamanini F, Bione S, Mancini M, Herman G, Chatterjee A, et al. A comparative transcriptional map of a region of 250 kb on the human and mouse X chromosome between the G6PD and the FLN1 genes. Genomics. 1995;28:377-82 pubmed
    The transcriptional organization of the region of the mouse X chromosome between the G6pd and the Fln1 genes was studied in detail, and it was compared with the syntenic region of the human chromosome...
  3. Nallapalli R, Ibrahim M, Zhou A, Bandaru S, Sunkara S, Redfors B, et al. Targeting filamin A reduces K-RAS-induced lung adenocarcinomas and endothelial response to tumor growth in mice. Mol Cancer. 2012;11:50 pubmed publisher
    Many human cancer cells express filamin A (FLNA), an actin-binding structural protein that interacts with a diverse set of cell signaling proteins, but little is known about the biological importance of FLNA in tumor development...
  4. Frey N, Richardson J, Olson E. Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. Proc Natl Acad Sci U S A. 2000;97:14632-7 pubmed
    ..Calsarcins represent a novel family of sarcomeric proteins that link calcineurin with the contractile apparatus, thereby potentially coupling muscle activity to calcineurin activation. ..
  5. Falet H, Pollitt A, Begonja A, Weber S, Duerschmied D, Wagner D, et al. A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med. 2010;207:1967-79 pubmed publisher
    b>Filamin A (FlnA) cross-links actin filaments and connects the Von Willebrand factor receptor GPIb-IX-V to the underlying cytoskeleton in platelets...
  6. Johansen L, Naumanen T, Knudsen A, Westerlund N, Gromova I, Junttila M, et al. IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration. J Cell Sci. 2008;121:854-64 pubmed publisher
    ..Cytosolic IKAP co-purified with proteins involved in cell migration, including filamin A, which is also involved in neuronal migration...
  7. Gravante B, Barbuti A, Milanesi R, Zappi I, Viscomi C, DiFrancesco D. Interaction of the pacemaker channel HCN1 with filamin A. J Biol Chem. 2004;279:43847-53 pubmed
    ..Through the use of a yeast two-hybrid technique, here we showed that filamin A interacts with HCN1, an HCN isoform widely expressed in the brain, but not with HCN2 or HCN4...
  8. Nomachi A, Nishita M, Inaba D, Enomoto M, Hamasaki M, Minami Y. Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A. J Biol Chem. 2008;283:27973-81 pubmed publisher
    ..Additionally, the association of Ror2 with the actin-binding protein filamin A is required for Wnt5a-induced JNK activation and polarized cell migration...
  9. Jurak Begonja A, Hoffmeister K, Hartwig J, Falet H. FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly. Blood. 2011;118:2285-95 pubmed publisher
    b>Filamin A (FlnA) is a large cytoplasmic protein that crosslinks actin filaments and anchors membrane receptors and signaling intermediates...
  10. Pinto V, Senini V, Wang Y, Kazembe M, McCulloch C. Filamin A protects cells against force-induced apoptosis by stabilizing talin- and vinculin-containing cell adhesions. FASEB J. 2014;28:453-63 pubmed publisher
    ..Protection against force-induced cell death may be mediated by filamin A (FLNa), an actin-binding protein that regulates ?1 integrin-mediated cell adhesion...
  11. Lian G, Kanaujia S, Wong T, Sheen V. FilaminA and Formin2 regulate skeletal, muscular, and intestinal formation through mesenchymal progenitor proliferation. PLoS ONE. 2017;12:e0189285 pubmed publisher
    ..We have previously shown that actin-binding Filamin A (FlnA) and actin-nucleating Formin 2 (Fmn2) influence the development of the brain causing microcephaly in mice...
  12. Bae D, Schaefer M, Partan B, Muglia L. Characterization of the mouse DAX-1 gene reveals evolutionary conservation of a unique amino-terminal motif and widespread expression in mouse tissue. Endocrinology. 1996;137:3921-7 pubmed
    ..Future studies using mouse models of altered DAX-1 expression will be critical in defining the role of this factor in tissue- and development-specific gene regulation. ..
  13. van der Flier A, Kuikman I, Kramer D, Geerts D, Kreft M, Takafuta T, et al. Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. J Cell Biol. 2002;156:361-76 pubmed
    ..These findings suggest that specific combinations of filamin mRNA splicing events modulate the organization of the actin cytoskeleton and the binding affinity for integrins. ..
  14. Gay O, Gilquin B, Nakamura F, Jenkins Z, McCartney R, Krakow D, et al. RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape. Proc Natl Acad Sci U S A. 2011;108:11464-9 pubmed publisher
    ..We next identify the actin-binding filamin A (FLNA) protein as the downstream effector of refilins...
  15. Lu J, Lian G, Lenkinski R, De Grand A, Vaid R, Bryce T, et al. Filamin B mutations cause chondrocyte defects in skeletal development. Hum Mol Genet. 2007;16:1661-75 pubmed
    ..These data suggest that disruption of the ECM-beta1-integrin-Flnb pathway contributes to defects in vertebral and distal limb development, similar to those seen in the human autosomal recessive SCT due to Flnb mutations. ..
  16. Leung R, Wang Y, Cuddy K, Sun C, Magalhaes J, Grynpas M, et al. Filamin A regulates monocyte migration through Rho small GTPases during osteoclastogenesis. J Bone Miner Res. 2010;25:1077-91 pubmed publisher
    ..Cellular migration requires leading-edge actin cytoskeleton assembly that drives cellular locomotion. Filamin A (FLNa) cross-links F-actin filaments in the leading edge of migrating cells and also has been shown to regulate ..
  17. Yu N, Erb L, Shivaji R, Weisman G, Seye C. Binding of the P2Y2 nucleotide receptor to filamin A regulates migration of vascular smooth muscle cells. Circ Res. 2008;102:581-8 pubmed publisher
    ..Here, we identified filamin A (FLNa) as a P2Y(2)R-interacting protein using a yeast 2-hybrid system screen with the C-terminal region of the ..
  18. Noam Y, Ehrengruber M, Koh A, Feyen P, Manders E, Abbott G, et al. Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons. J Biol Chem. 2014;289:5889-903 pubmed publisher
    The actin-binding protein filamin A (FLNa) regulates neuronal migration during development, yet its roles in the mature brain remain largely obscure...
  19. Castoria G, D Amato L, Ciociola A, Giovannelli P, Giraldi T, Sepe L, et al. Androgen-induced cell migration: role of androgen receptor/filamin A association. PLoS ONE. 2011;6:e17218 pubmed publisher
    ..migration and observed that challenging NIH3T3 cells with 10 nM R1881 rapidly induces interaction of AR with filamin A (FlnA) at cytoskeleton. AR/FlnA complex recruits integrin beta 1, thus activating its dependent cascade...
  20. Leduc M, Savage H, Stearns T, Cario C, Walsh K, Paigen B, et al. A major X-linked locus affects kidney function in mice. Mol Genet Genomics. 2012;287:845-54 pubmed publisher
    ..Finally, this study demonstrates the significance of the X chromosome in the genetic determination of albuminuria. ..
  21. Lian G, Dettenhofer M, Lu J, Downing M, Chenn A, Wong T, et al. Filamin A- and formin 2-dependent endocytosis regulates proliferation via the canonical Wnt pathway. Development. 2016;143:4509-4520 pubmed
    ..Here, we report that the actin-binding protein filamin A (FlnA) physically interacts with the actin-nucleating protein formin 2 (Fmn2)...
  22. Dorr K, Amin N, Kuchenbrod L, Labiner H, Charpentier M, Pevny L, et al. Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development. Development. 2015;142:2037-47 pubmed publisher
    ..Taken together, these studies establish a role for CASZ1 in mammalian cardiomyocyte cell cycle progression in both the first and second heart fields. ..
  23. Sarkisian M, Bartley C, Chi H, Nakamura F, Hashimoto Torii K, Torii M, et al. MEKK4 signaling regulates filamin expression and neuronal migration. Neuron. 2006;52:789-801 pubmed
    ..Collectively, our results demonstrate a link between MEKK4 and Fln-A that impacts neuronal migration initiation and provides insight into the pathogenesis of human PVH. ..
  24. Zheng X, Zhou A, Rouhi P, Uramoto H, Boren J, Cao Y, et al. Hypoxia-induced and calpain-dependent cleavage of filamin A regulates the hypoxic response. Proc Natl Acad Sci U S A. 2014;111:2560-5 pubmed publisher
    ..We have discovered that filamin A (FLNA), a large cytoskeletal actin-binding protein, physically interacts with HIF-1? and promotes tumor growth ..
  25. Juo L, Liao W, Shih Y, Yang B, Liu A, Yan Y. HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles. J Cell Sci. 2016;129:1661-70 pubmed publisher
    ..Collectively, our findings suggest that HSPB7 is essential for maintaining muscle integrity, which is achieved through its interaction with FLNC, in order to prevent the occurrence and progression of myopathy. ..
  26. Luo W, Yu C, Lieu Z, Allard J, Mogilner A, Sheetz M, et al. Analysis of the local organization and dynamics of cellular actin networks. J Cell Biol. 2013;202:1057-73 pubmed publisher
    ..II and containing the formin disheveled-associated activator of morphogenesis 1 (DAAM1) and the cross-linker filamin A (FlnA)...
  27. Adams M, Simms R, Abdelhamed Z, Dawe H, Szymanska K, Logan C, et al. A meckelin-filamin A interaction mediates ciliogenesis. Hum Mol Genet. 2012;21:1272-86 pubmed publisher
    ..Here, we found that the cytoplasmic domain of meckelin directly interacts with the actin-binding protein filamin A, potentially at the apical cell surface associated with the basal body...
  28. Kanaji T, Ware J, Okamura T, Newman P. GPIb? regulates platelet size by controlling the subcellular localization of filamin. Blood. 2012;119:2906-13 pubmed publisher
    ..Taken together, these data demonstrate that coordinated expression of GPIb? and filamin is required for efficient trafficking of either protein to the cell surface, and for production of normal-sized platelets. ..
  29. Segura I, Lange C, Knevels E, Moskalyuk A, Pulizzi R, Eelen G, et al. The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A. Cell Rep. 2016;14:2653-67 pubmed publisher
    ..We identified the actin cross-linker filamin A (FLNA) as a target of PHD2 mediating these effects...
  30. Mohammadi H, Pinto V, Wang Y, Hinz B, Janmey P, McCulloch C. Filamin A Mediates Wound Closure by Promoting Elastic Deformation and Maintenance of Tension in the Collagen Matrix. J Invest Dermatol. 2015;135:2852-2861 pubmed publisher
    ..We examined the role of filamin A (FLNa), an actin filament cross-linking protein, in wound contraction and maintenance of matrix tension...
  31. Goldberg S, Glogauer J, Grynpas M, Glogauer M. Deletion of filamin A in monocytes protects cortical and trabecular bone from post-menopausal changes in bone microarchitecture. Calcif Tissue Int. 2015;97:113-24 pubmed publisher
    The objective of the study was to determine the in vivo role of Filamin A (FLNA) in osteoclast generation and function, through the assessment of trabecular bone morphology, bone turnover, and the resulting changes in mechanical ..
  32. Nagano T, Morikubo S, Sato M. Filamin A and FILIP (Filamin A-Interacting Protein) regulate cell polarity and motility in neocortical subventricular and intermediate zones during radial migration. J Neurosci. 2004;24:9648-57 pubmed
    ..We show here that Filamin A, a well known actin-binding protein, determines the shape of neocortical neurons during radial migration in vivo...
  33. Huq A, Lovell R, Sampson M, Decker W, Dinulos M, Disteche C, et al. Isolation, mapping, and functional expression of the mouse X chromosome glycerol kinase gene. Genomics. 1996;36:530-4 pubmed
    ..To confirm the functional identity of the cDNA, transient transfection of the cDNA into COS7 cells was shown to cause a marked elevation in glycerol kinase activity. ..
  34. Nakamura F, Kumeta K, Hida T, Isono T, Nakayama Y, Kuramata Matsuoka E, et al. Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling. Nat Commun. 2014;5:5325 pubmed publisher
    ..CRMP1(Ser522Asp) weakens the F-actin gelation crosslinked by Filamin-A. Thus, phosphorylated CRMP1 may remove Filamin-A from the actin cytoskeleton to facilitate its remodelling. ..
  35. Sun C, Forster C, Nakamura F, Glogauer M. Filamin-A regulates neutrophil uropod retraction through RhoA during chemotaxis. PLoS ONE. 2013;8:e79009 pubmed publisher
    Filamin-A (FLNa) has been shown to be a key cross-linker of actin filaments in the leading edge of a motile melanoma cell line, however its role in neutrophils undergoing chemotaxis is unknown...
  36. Funke B, Zuleger B, Benavente R, Schuster T, Goller M, Stevenin J, et al. The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins. Nucleic Acids Res. 1996;24:3821-8 pubmed
    ..The interaction between mCBP and splicing factor 9G8 was confirmed in vivo. These results suggest a function of mCBP in RNA metabolism. ..
  37. Guiet R, Verollet C, Lamsoul I, Cougoule C, Poincloux R, Labrousse A, et al. Macrophage mesenchymal migration requires podosome stabilization by filamin A. J Biol Chem. 2012;287:13051-62 pubmed publisher
    b>Filamin A (FLNa) is a cross-linker of actin filaments and serves as a scaffold protein mostly involved in the regulation of actin polymerization...
  38. Rafizadeh S, Zhang Z, Woltz R, Kim H, Myers R, Lu L, et al. Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel. Proc Natl Acad Sci U S A. 2014;111:9989-94 pubmed publisher
    ..Here, we demonstrate that filamin A, a cytoskeletal protein, augments the trafficking of SK2 channels in cardiac myocytes...
  39. Mezawa M, Pinto V, Kazembe M, Lee W, McCulloch C. Filamin A regulates the organization and remodeling of the pericellular collagen matrix. FASEB J. 2016;30:3613-3627 pubmed
    ..We examined the role of the actin-binding protein, filamin A (FLNa), in pericellular collagen remodeling...
  40. Doering C, Rehak R, Bonfield S, Peloquin J, Stell W, Mema S, et al. Modified Ca(v)1.4 expression in the Cacna1f(nob2) mouse due to alternative splicing of an ETn inserted in exon 2. PLoS ONE. 2008;3:e2538 pubmed publisher
    ..4 mutant may be incapable of interacting with cytoskeletal filamin proteins. These changes, do not alter the ability of the Cacna1f(nob2) mouse to detect and follow moving sine-wave gratings compared to their wild type counterparts. ..
  41. Mizuhashi K, Kanamoto T, Moriishi T, Muranishi Y, Miyazaki T, Terada K, et al. Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements. Hum Mol Genet. 2014;23:2953-67 pubmed publisher
    ..These results suggest that Cfms are essential partner molecules of Flnb in regulating differentiation and proliferation of chondryocytes and actin dynamics. ..
  42. Deussing J, Roth W, Rommerskirch W, Wiederanders B, Von Figura K, Peters C. The genes of the lysosomal cysteine proteinases cathepsin B, H, L, and S map to different mouse chromosomes. Mamm Genome. 1997;8:241-5 pubmed
  43. Stulić M, Jantsch M. Spatio-temporal profiling of Filamin A RNA-editing reveals ADAR preferences and high editing levels outside neuronal tissues. RNA Biol. 2013;10:1611-7 pubmed publisher
    ..Using knockout mice, we show that ADARB1 (ADAR2) is responsible for the majority of FLNA editing, while ADAR1 can edit filamin ? mRNA in some tissues quite efficiently...
  44. Yoshida N, Ogata T, Tanabe K, Li S, Nakazato M, Kohu K, et al. Filamin A-bound PEBP2beta/CBFbeta is retained in the cytoplasm and prevented from functioning as a partner of the Runx1 transcription factor. Mol Cell Biol. 2005;25:1003-12 pubmed
    ..We addressed the mechanism by which PEBP2beta localizes to the cytoplasm and found that it is associated with filamin A, an actin-binding protein...
  45. Mishra L, Tully R, Monga S, Yu P, Cai T, Makalowski W, et al. Praja1, a novel gene encoding a RING-H2 motif in mouse development. Oncogene. 1997;15:2361-8 pubmed
    ..This is strengthened by the similarity of Praja1 to rat Neurodap1, whose product has been shown to localize to the endoplasmic reticulum and golgi in brain. ..
  46. Norris R, Moreno Rodriguez R, Wessels A, Merot J, Bruneval P, Chester A, et al. Expression of the familial cardiac valvular dystrophy gene, filamin-A, during heart morphogenesis. Dev Dyn. 2010;239:2118-27 pubmed publisher
    ..Characterization of the temporal and spatial expression pattern of filamin-A during cardiac morphogenesis is a crucial first step in our understanding of how mutations in filamin-A result in clinically relevant valve disease. ..
  47. DISSMORE T, Seye C, Medeiros D, Weisman G, Bradford B, Mamedova L. The P2Y2 receptor mediates uptake of matrix-retained and aggregated low density lipoprotein in primary vascular smooth muscle cells. Atherosclerosis. 2016;252:128-135 pubmed publisher
  48. Cho Y, Park D, Cavalli V. Filamin A is required in injured axons for HDAC5 activity and axon regeneration. J Biol Chem. 2015;290:22759-70 pubmed publisher
    ..Here we reveal that HDAC5 interacts with the actin binding protein filamin A via its C-terminal domain...
  49. Henkels K, Mallets E, Dennis P, Gomez Cambronero J. S6K is a morphogenic protein with a mechanism involving Filamin-A phosphorylation and phosphatidic acid binding. FASEB J. 2015;29:1299-313 pubmed publisher
    ..9-fold increase in S6K catalytic activity. This was followed by an increase in Filamin A (FLNA) functionality as measured by phospho-FLNA (S(2152)) expression and by a subsequent elevation of actin ..
  50. Sheen V, Feng Y, Graham D, Takafuta T, Shapiro S, Walsh C. Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact. Hum Mol Genet. 2002;11:2845-54 pubmed
    Mutations in the X-linked gene Filamin A (FLNA) lead to the human neurological disorder, periventricular heterotopia (PH)...
  51. Lian G, Lu J, Hu J, Zhang J, Cross S, Ferland R, et al. Filamin a regulates neural progenitor proliferation and cortical size through Wee1-dependent Cdk1 phosphorylation. J Neurosci. 2012;32:7672-84 pubmed publisher
    ..Mutations in the cytoskeleton-associated gene filamin A (FlnA) cause the human disorder periventricular heterotopia (PH)...
  52. Sarkisian M, Bartley C, Rakic P. Trouble making the first move: interpreting arrested neuronal migration in the cerebral cortex. Trends Neurosci. 2008;31:54-61 pubmed publisher
    ..In human telencephalon, this malformation is most commonly associated with Filamin-A (FLNa) mutations...
  53. Liao W, Juo L, Shih Y, Chen Y, Yan Y. HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity. PLoS Genet. 2017;13:e1006984 pubmed publisher
    ..In conclusion, our findings characterize HSPB7 as an intercalated disc protein and suggest it has an essential role in maintaining intercalated disc integrity and conduction function in the adult heart. ..
  54. Wang H, Guo J, Lin Z, Namgoong S, Oh J, Kim N. Filamin A is required for spindle migration and asymmetric division in mouse oocytes. FASEB J. 2017;31:3677-3688 pubmed publisher
    ..In this study, filamin A (FLNA) was found to be an essential actin regulator that controlled spindle migration and asymmetric division ..
  55. Cranmer S, Ashworth K, Yao Y, Berndt M, Ruggeri Z, Andrews R, et al. High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIb?-filamin interaction. Blood. 2011;117:2718-27 pubmed publisher
    ..human GPIb? (hGPIb?(WT)), or a mutant form of human GPIb? that has a selective defect in its ability to bind filamin A and anchor to the membrane skeleton (hGPIb?(FW)-Phe568Ala and Trp570Ala substitutions)...
  56. Hu J, Lu J, Goyal A, Wong T, Lian G, Zhang J, et al. Opposing FlnA and FlnB interactions regulate RhoA activation in guiding dynamic actin stress fiber formation and cell spreading. Hum Mol Genet. 2017;26:1294-1304 pubmed publisher
    ..To investigate the roles of different filamin isoforms, we focused on FlnA and FlnB interactions in the cartilage growth plate, since mutations in both molecules cause chondrodysplasias...
  57. Retailleau K, Duprat F, Arhatte M, Ranade S, Peyronnet R, Martins J, et al. Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling. Cell Rep. 2015;13:1161-1171 pubmed publisher
    ..In conclusion, we have established the connection between an early mechanosensitive process, involving Piezo1 in smooth muscle cells, and a clinically relevant arterial remodeling. ..
  58. Lad Y, Jiang P, Ruskamo S, Harburger D, Ylanne J, Campbell I, et al. Structural basis of the migfilin-filamin interaction and competition with integrin beta tails. J Biol Chem. 2008;283:35154-63 pubmed publisher
    ..We report that the N-terminal portion of migfilin can bind all three human filamins (FLNa, -b, or -c) and that there are multiple migfilin-binding sites in FLNa...
  59. Briggs L, Phelps A, Brown E, Kakarla J, Anderson R, van den Hoff M, et al. Expression of the BMP receptor Alk3 in the second heart field is essential for development of the dorsal mesenchymal protrusion and atrioventricular septation. Circ Res. 2013;112:1420-32 pubmed publisher
    ..Perturbation of Alk3-mediated BMP signaling from the SHF results in impaired development of the DMP and ostium primum defects. ..
  60. Guo W, Lovell R, Zhang Y, Huang B, Burris T, Craigen W, et al. Ahch, the mouse homologue of DAX1: cloning, characterization and synteny with GyK, the glycerol kinase locus. Gene. 1996;178:31-4 pubmed
  61. Ernkvist M, Luna Persson N, Audebert S, Lecine P, Sinha I, Liu M, et al. The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. Blood. 2009;113:244-53 pubmed publisher
    ..Taken together, our results indicate that the directional migration of capillaries in the embryo is governed by the Amot:Patj/Mupp1:Syx signaling that controls local GTPase activity. ..
  62. Farrington Rock C, Kirilova V, Dillard Telm L, Borowsky A, Chalk S, Rock M, et al. Disruption of the Flnb gene in mice phenocopies the human disease spondylocarpotarsal synostosis syndrome. Hum Mol Genet. 2008;17:631-41 pubmed
    ..These findings suggest that spinal segmentation can occur normally in the absence of filamin B, but the protein is required for maintenance of intervertebral, carpal and sternal joints, and the joint fusion process commences antenatally...
  63. Gariboldi M, Maestrini E, Canzian F, Manenti G, De Gregorio L, Rivella S, et al. Comparative mapping of the actin-binding protein 280 genes in human and mouse. Genomics. 1994;21:428-30 pubmed
    Two genes encode actin-binding protein 280 isoforms. ABP-280 or filamin (FLN1) is present in the cytoskeleton of many cell types, whereas expression of FLN2 is limited to skeletal muscle and heart...
  64. Lu J, Tiao G, Folkerth R, Hecht J, Walsh C, Sheen V. Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia. J Comp Neurol. 2006;494:476-84 pubmed
    ..in the vesicle transport ADP-ribosylation factor guanine exchange factor 2 gene (ARFGEF2) or the actin-binding Filamin A (FLNA) gene cause PH...
  65. Retailleau K, Arhatte M, Demolombe S, Peyronnet R, Baudrie V, Jodar M, et al. Arterial Myogenic Activation through Smooth Muscle Filamin A. Cell Rep. 2016;14:2050-2058 pubmed publisher
    Mutations in the filamin A (FlnA) gene are frequently associated with severe arterial abnormalities, although the physiological role for this cytoskeletal element remains poorly understood in vascular cells...
  66. Ishihara S, Nishikimi A, Umemoto E, Miyasaka M, Saegusa M, Katagiri K. Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis. Nat Commun. 2015;6:8982 pubmed publisher
    ..This Rap1-dependent regulation of T-cell circulation prevents the onset of colitis. ..
  67. Bandaru S, Grönros J, Redfors B, Çil Ã, Pazooki D, Salimi R, et al. Deficiency of filamin A in endothelial cells impairs left ventricular remodelling after myocardial infarction. Cardiovasc Res. 2015;105:151-9 pubmed publisher
    Actin-binding protein filamin A (FLNA) regulates signal transduction important for cell locomotion, but the role of FLNA after myocardial infarction (MI) has not been explored...
  68. Yamauchi T, Ishidao T, Nomura T, Shinagawa T, Tanaka Y, Yonemura S, et al. A B-Myb complex containing clathrin and filamin is required for mitotic spindle function. EMBO J. 2008;27:1852-62 pubmed publisher
    ..Thus, identification of the Myb-Clafi complex reveals a previously unrecognized function of B-Myb that may contribute to its role in chromosome stability, possibly, tumour suppression. ..
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