Fkbp5

Summary

Gene Symbol: Fkbp5
Description: FK506 binding protein 5
Alias: D17Ertd592e, Dit1, FKBP-5, FKBP51, peptidyl-prolyl cis-trans isomerase FKBP5, 51 kDa FK506-binding protein, 51 kDa FKBP, PPIase FKBP5, rotamase
Species: mouse
Products:     Fkbp5

Top Publications

  1. Magee J, Chang L, Stormo G, Milbrandt J. Direct, androgen receptor-mediated regulation of the FKBP5 gene via a distal enhancer element. Endocrinology. 2006;147:590-8 pubmed
    ..we used the mouse prostate to elucidate the mechanisms through which AR regulates another direct target, FKBP5, in vivo...
  2. Wagner K, Marinescu D, Hartmann J, Wang X, Labermaier C, Scharf S, et al. Differences in FKBP51 regulation following chronic social defeat stress correlate with individual stress sensitivity: influence of paroxetine treatment. Neuropsychopharmacology. 2012;37:2797-808 pubmed publisher
    Various clinical studies have identified FK506-binding protein 51 (FKBP51) as a target gene involved in the development of psychiatric disorders such as depression...
  3. O Leary J, Dharia S, Blair L, Brady S, Johnson A, Peters M, et al. A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51. PLoS ONE. 2011;6:e24840 pubmed publisher
    The gene FKBP5 codes for FKBP51, a co-chaperone protein of the Hsp90 complex that increases with age. Through its association with Hsp90, FKBP51 regulates the glucocorticoid receptor (GR)...
  4. Hartmann J, Wagner K, Liebl C, Scharf S, Wang X, Wolf M, et al. The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress. Neuropharmacology. 2012;62:332-9 pubmed publisher
    ..The FK506-binding protein 51 (FKBP5), a co-chaperone of the Hsp90 and component of the chaperone-receptor heterocomplex, has been shown to reduce ..
  5. Gallo L, Lagadari M, Piwien Pilipuk G, Galigniana M. The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress. J Biol Chem. 2011;286:30152-60 pubmed publisher
    Confocal microscopy images revealed that the tetratricopeptide repeat motif (TPR) domain immunophilin FKBP51 shows colocalization with the specific mitochondrial marker MitoTracker...
  6. Daudt D, Yorio T. FKBP51 protects 661w cell culture from staurosporine-induced apoptosis. Mol Vis. 2011;17:1172-81 pubmed
    ..these properties through interaction with FK506 binding proteins (FKBP), including FK506 binding protein 51 (FKBP51). In this study, we examine the effects of FKBP51 as a neuroprotective agent on a neuronal cell line...
  7. Jinwal U, Koren J, Borysov S, Schmid A, Abisambra J, Blair L, et al. The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules. J Neurosci. 2010;30:591-9 pubmed publisher
    ..Here, we show that the Hsp90 cochaperone, FK506-binding protein 51 (FKBP51), which possesses both an Hsp90-interacting tetratricopeptide domain and a peptidyl-prolyl cis-trans isomerase (..
  8. Yang X, Ewald E, Huo Y, Tamashiro K, Salvatori R, Sawa A, et al. Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5. Biochem Biophys Res Commun. 2012;420:570-5 pubmed publisher
    ..As persistent glucocorticoid-induced loss of DNA methylation in FK506 binding protein 5 (Fkbp5) was previously observed in the hippocampus and blood and in the neuronal cell line HT-22, we asked whether these ..
  9. Touma C, Gassen N, Herrmann L, Cheung Flynn J, Büll D, Ionescu I, et al. FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior. Biol Psychiatry. 2011;70:928-36 pubmed publisher
    The Hsp90 cochaperone FK506 binding protein 5 (FKBP5) is an established regulator of the glucocorticoid receptor (GR), and numerous genetic studies have linked it to stress-related diseases such as major depression or posttraumatic ..

More Information

Publications62

  1. Tranguch S, Cheung Flynn J, Daikoku T, Prapapanich V, Cox M, Xie H, et al. Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. Proc Natl Acad Sci U S A. 2005;102:14326-31 pubmed
    ..Collectively, the present investigation provides evidence for an in vivo role for this cochaperone in regulating tissue-specific hormone action and its critical role in uterine receptivity for implantation. ..
  2. Davies T, Ning Y, SANCHEZ E. A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. J Biol Chem. 2002;277:4597-600 pubmed
    ..dissociation of the cytoplasmic GR heterocomplex, binding of hormone-induced substitution of one immunophilin (FKBP51) for another (FKBP52), and concomitant recruitment of the transport protein dynein while leaving Hsp90 unchanged...
  3. Scharf S, Liebl C, Binder E, Schmidt M, Muller M. Expression and regulation of the Fkbp5 gene in the adult mouse brain. PLoS ONE. 2011;6:e16883 pubmed publisher
    ..The activity of the GR is modulated by a variety of proteins, including the co-chaperone FK506 binding protein 51 (FKBP5)...
  4. Yeh W, Li T, Bierer B, McKnight S. Identification and characterization of an immunophilin expressed during the clonal expansion phase of adipocyte differentiation. Proc Natl Acad Sci U S A. 1995;92:11081-5 pubmed
    ..One such mRNA encodes an immunophilin hereby designated FKBP51. In this report we provide the initial molecular characterization of FKBP51.
  5. Yang L, Isoda F, Yen K, Kleopoulos S, Janssen W, Fan X, et al. Hypothalamic Fkbp51 is induced by fasting, and elevated hypothalamic expression promotes obese phenotypes. Am J Physiol Endocrinol Metab. 2012;302:E987-91 pubmed publisher
    ..One such gene was Fkbp51 (FK506 binding protein 5; Locus NP_034350)...
  6. Denny W, Valentine D, Reynolds P, Smith D, Scammell J. Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding. Endocrinology. 2000;141:4107-13 pubmed publisher
    ..We have demonstrated that the FK506-binding immunophilin FKBP51 is elevated in squirrel monkey lymphocytes (SML) and, in preliminary studies, have shown that squirrel monkey ..
  7. Scammell J, Denny W, Valentine D, Smith D. Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three New World primates. Gen Comp Endocrinol. 2001;124:152-65 pubmed publisher
    ..Third, Western blots showed elevated expression of FKBP51 in New World primate cells and liver samples from two squirrel monkey species...
  8. Yong W, Yang Z, Periyasamy S, Chen H, Yucel S, Li W, et al. Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology. J Biol Chem. 2007;282:5026-36 pubmed
    Fkbp52 and Fkbp51 are tetratricopeptide repeat proteins found in steroid receptor complexes, and Fkbp51 is an androgen receptor (AR) target gene...
  9. Hubler T, Scammell J. Intronic hormone response elements mediate regulation of FKBP5 by progestins and glucocorticoids. Cell Stress Chaperones. 2004;9:243-52 pubmed
    Expression of FKBP51, a large molecular weight immunophilin, is strongly enhanced by glucocorticoids, progestins, and androgens. However, the activity of a 3...
  10. Gassen N, Hartmann J, Schmidt M, Rein T. FKBP5/FKBP51 enhances autophagy to synergize with antidepressant action. Autophagy. 2015;11:578-80 pubmed publisher
    ..punctum, we summarize and discuss our recent findings that provide evidence for a role of the cochaperone FKBP5/FKBP51 (FK506 binding protein 5) in autophagy as a prerequisite for antidepressant action in cells, mice, and humans...
  11. Baughman G, Harrigan M, Campbell N, Nurrish S, Bourgeois S. Genes newly identified as regulated by glucocorticoids in murine thymocytes. Mol Endocrinol. 1991;5:637-44 pubmed
    ..ETn. The remaining clones represent new, unidentified genes induced by glucocorticoids in murine thymocytes and in the WEHI-7TG cell line. ..
  12. Lavebratt C, Aberg E, Sjöholm L, Forsell Y. Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort. J Affect Disord. 2010;125:249-55 pubmed publisher
    Genetic variations in FKBP5, BDNF, P2RX7 and CACNA1 are current candidates for involvement in depression...
  13. Hoeijmakers L, Harbich D, Schmid B, Lucassen P, Wagner K, Schmidt M, et al. Depletion of FKBP51 in female mice shapes HPA axis activity. PLoS ONE. 2014;9:e95796 pubmed publisher
    ..For instance, variations in the gene encoding the FK506 binding protein 51 (FKBP51) have been repeatedly associated with mood and anxiety...
  14. Madon Simon M, Grad I, Bayo P, Perez P, Picard D. Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23. PLoS ONE. 2017;12:e0180035 pubmed publisher
  15. Zhang L, Qiu B, Wang T, Wang J, Liu M, Xu Y, et al. Loss of FKBP5 impedes adipocyte differentiation under both normoxia and hypoxic stress. Biochem Biophys Res Commun. 2017;485:761-767 pubmed publisher
    FK506-binding protein 51 (FKBP51) is one of the most important regulators in the GR-mediated stress response, and we previously demonstrated that loss of FKBP5 arrests adipogenesis and renders mice resistant to diet-induced obesity (DIO)...
  16. Maeda Y, Fukushima K, Kariya S, Orita Y, Nishizaki K. Intratympanic dexamethasone up-regulates Fkbp5 in the cochleae of mice in vivo. Acta Otolaryngol. 2012;132:4-9 pubmed publisher
    ..real-time RT-PCR demonstrated that intratympanic dexamethasone significantly up-regulates the expression of Fkbp5 in cochleae of mice in vivo...
  17. Toneatto J, Guber S, Charó N, Susperreguy S, Schwartz J, Galigniana M, et al. Dynamic mitochondrial-nuclear redistribution of the immunophilin FKBP51 is regulated by the PKA signaling pathway to control gene expression during adipocyte differentiation. J Cell Sci. 2013;126:5357-68 pubmed publisher
    ..receptor (GR) that forms a heterocomplex with Hsp90•Hsp70 and one high molecular weight immunophilin, either FKBP51 or FKBP52...
  18. Kollmannsberger L, Gassen N, Bultmann A, Hartmann J, Weber P, Schmidt M, et al. Increased glyoxalase-1 levels in Fkbp5 knockout mice caused by glyoxalase-1 gene duplication. G3 (Bethesda). 2013;3:1311-3 pubmed publisher
    b>Fkbp5 is genetically linked to stress-related diseases. Fkbp5 knockout mice are available and widely used to explore the role of Fkbp5 in health and disease...
  19. Akiyama T, Shiraishi T, Qin J, Konno H, Akiyama N, Shinzawa M, et al. Mitochondria-nucleus shuttling FK506-binding protein 51 interacts with TRAF proteins and facilitates the RIG-I-like receptor-mediated expression of type I IFN. PLoS ONE. 2014;9:e95992 pubmed publisher
    ..However, the precise regulatory mechanisms remain unclear. Here, we show the role of FK506-binding protein 51 (FKBP51) in regulating the dsRNA-dependent expression of type I IFN...
  20. Gassen N, Hartmann J, Zannas A, Kretzschmar A, Zschocke J, Maccarrone G, et al. FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications. Mol Psychiatry. 2016;21:277-89 pubmed publisher
    ..We discovered that the suggested psychiatric risk factor FK506 binding protein 51 (FKBP51) increases phosphorylation of GSK3β at serine 9 (pGSK3β(S9))...
  21. Balsevich G, Häusl A, Meyer C, Karamihalev S, Feng X, Pöhlmann M, et al. Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function. Nat Commun. 2017;8:1725 pubmed publisher
    ..Here we show that FKBP51 plays a role in energy and glucose homeostasis...
  22. Albu S, Romanowski C, Letizia Curzi M, Jakubcakova V, Flachskamm C, Gassen N, et al. Deficiency of FK506-binding protein (FKBP) 51 alters sleep architecture and recovery sleep responses to stress in mice. J Sleep Res. 2014;23:176-85 pubmed publisher
    FK506-binding protein 51 (FKBP51) is a co-chaperone of the glucocorticoid receptor, functionally linked to its activity via an ultra-short negative feedback loop...
  23. Stechschulte L, Hinds T, Khuder S, Shou W, Najjar S, SANCHEZ E. FKBP51 controls cellular adipogenesis through p38 kinase-mediated phosphorylation of GR? and PPAR?. Mol Endocrinol. 2014;28:1265-75 pubmed publisher
    ..We have shown that FK506-binding protein 51 (FKBP51) represses the Akt-p38 kinase pathway to reciprocally inhibit GR? but stimulate PPAR? by targeting serine 112 (..
  24. Kim Y, Kim Y, Lee J, Kim E, Park Y, Choe S, et al. Functional changes in myeloid-derived suppressor cells (MDSCs) during tumor growth: FKBP51 contributes to the regulation of the immunosuppressive function of MDSCs. J Immunol. 2012;188:4226-34 pubmed publisher
    ..Among differentially expressed genes, FK506 binding protein 51 (FKBP51), which is a member of the immunophilin protein family and plays a role in immunoregulation, was increased in the ..
  25. Longo Guess C, Gagnon L, Cook S, Wu J, Zheng Q, Johnson K. A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice. Proc Natl Acad Sci U S A. 2005;102:7894-9 pubmed
    ..Our localization of TMHS to the apical membrane of inner ear hair cells during the period of stereocilia formation suggests a function in hair bundle morphogenesis. ..
  26. Gassen N, Hartmann J, Zschocke J, Stepan J, Häfner K, Zellner A, et al. Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans. PLoS Med. 2014;11:e1001755 pubmed publisher
    FK506 binding protein 51 (FKBP51) is an Hsp90 co-chaperone and regulator of the glucocorticoid receptor, and consequently of stress physiology...
  27. Echeverria P, Mazaira G, Erlejman A, Gomez Sanchez C, Piwien Pilipuk G, Galigniana M. Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta. Mol Cell Biol. 2009;29:4788-97 pubmed publisher
    ..Importantly, GR cross-linked to the hsp90 heterocomplex was able to translocate to the nucleus in digitonin-permeabilized cells treated with steroid, suggesting that GR could pass through the pore in its untransformed state. ..
  28. Sevilla L, Bayo P, Latorre V, Sanchis A, Perez P. Glucocorticoid receptor regulates overlapping and differential gene subsets in developing and adult skin. Mol Endocrinol. 2010;24:2166-78 pubmed publisher
    ..We also found down-regulation of the antimicrobial peptide defensin ? 1 (Defb1) and FK506-binding protein 51 (Fkbp51)...
  29. Huang M, Schwandt M, Chester J, Kirchhoff A, Kao C, Liang T, et al. FKBP5 moderates alcohol withdrawal severity: human genetic association and functional validation in knockout mice. Neuropsychopharmacology. 2014;39:2029-38 pubmed publisher
    Alcohol withdrawal is associated with hypothalamic-pituitary-adrenal (HPA) axis dysfunction. The FKBP5 gene codes for a co-chaperone, FK506-binding protein 5, that exerts negative feedback on HPA axis function...
  30. Antunica Noguerol M, Budziñski M, Druker J, Gassen N, Sokn M, Senin S, et al. The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51. Cell Death Differ. 2016;23:1579-91 pubmed publisher
    FK506-binding protein 51 (FKBP51) regulates the activity of the glucocorticoid receptor (GR), and is therefore a key mediator of the biological actions of glucocorticoids...
  31. Shimoide T, Kawao N, Tamura Y, Morita H, Kaji H. Novel roles of FKBP5 in muscle alteration induced by gravity change in mice. Biochem Biophys Res Commun. 2016;479:602-606 pubmed publisher
    ..b>FKBP5 was extracted as a gene whose expression was enhanced by hypergravity through the vestibular system...
  32. Qiu B, Luczak S, Wall T, Kirchhoff A, Xu Y, Eng M, et al. The FKBP5 Gene Affects Alcohol Drinking in Knockout Mice and Is Implicated in Alcohol Drinking in Humans. Int J Mol Sci. 2016;17: pubmed publisher
    b>FKBP5 encodes FK506-binding protein 5, a glucocorticoid receptor (GR)-binding protein implicated in various psychiatric disorders and alcohol withdrawal severity...
  33. Cluning C, Ward B, Rea S, Arulpragasam A, Fuller P, Ratajczak T. The helix 1-3 loop in the glucocorticoid receptor LBD is a regulatory element for FKBP cochaperones. Mol Endocrinol. 2013;27:1020-35 pubmed publisher
    The heat-shock protein 90 (Hsp90) cochaperone FK506-binding protein 52 (FKBP52) upregulates, whereas FKBP51 inhibits, hormone binding and nuclear targeting of the glucocorticoid receptor (GR)...
  34. Nishida H, Miyagawa S, Matsumaru D, Wada Y, Satoh Y, Ogino Y, et al. Gene expression analyses on embryonic external genitalia: identification of regulatory genes possibly involved in masculinization processes. Congenit Anom (Kyoto). 2008;48:63-7 pubmed publisher
    ..From our studies we have identified candidate genes, Cyp1b1, Fkbp51 and MafB as potential androgen targets during mouse GT masculinization.
  35. Nair S, Rimerman R, Toran E, Chen S, Prapapanich V, Butts R, et al. Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor. Mol Cell Biol. 1997;17:594-603 pubmed
    A cDNA for human FKBP51 has been cloned and sequenced, and protein products have been expressed in both in vitro and bacterial systems...
  36. Kimura M, Nagai T, Matsushita R, Hashimoto A, Miyashita T, Hirohata S. Role of FK506 binding protein 5 (FKBP5) in osteoclast differentiation. Mod Rheumatol. 2013;23:1133-9 pubmed publisher
    We previously disclosed the enhanced expression of FK506 binding protein 5 (FKBP5) messenger RNA (mRNA) in bone marrow (BM) CD34(+) cells in rheumatoid arthritis (RA), in which systemic osteoporosis takes place...
  37. Martinez N, Chang H, Borrajo J, Gregory R. The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly. RNA. 2013;19:1583-93 pubmed publisher
    ..Here we identify the co-chaperones Fkbp4 and Fkbp5 as Ago2-associated proteins in mouse embryonic stem cells...
  38. Miyagawa S, Matsumaru D, Murashima A, Omori A, Satoh Y, Haraguchi R, et al. The role of sonic hedgehog-Gli2 pathway in the masculinization of external genitalia. Endocrinology. 2011;152:2894-903 pubmed publisher
    ..The current study identified hedgehog signaling pathway as a key factor not only for initial development but also for sexually dimorphic development of the external genitalia in coordination with androgen signaling. ..
  39. Rog Zielinska E, Thomson A, Kenyon C, Brownstein D, Moran C, Szumska D, et al. Glucocorticoid receptor is required for foetal heart maturation. Hum Mol Genet. 2013;22:3269-82 pubmed publisher
  40. Sabbagh J, O Leary J, Blair L, Klengel T, Nordhues B, Fontaine S, et al. Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency. PLoS ONE. 2014;9:e107241 pubmed publisher
    ..These SNPs increase FKBP51 protein expression through a mechanism involving demethylation of the gene and altered glucocorticoid signaling...
  41. Baughman G, Wiederrecht G, Campbell N, Martin M, Bourgeois S. FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition. Mol Cell Biol. 1995;15:4395-402 pubmed
    ..The novel immunophilin, FKBP51, is distinct from the previously isolated and sequenced 52-kDa murine FKBP, demonstrating 53% identity overall...
  42. Stechschulte L, Hinds T, Ghanem S, Shou W, Najjar S, SANCHEZ E. FKBP51 reciprocally regulates GR? and PPAR? activation via the Akt-p38 pathway. Mol Endocrinol. 2014;28:1254-64 pubmed publisher
    FK506-binding protein 51 (FKBP51) is a negative regulator of glucocorticoid receptor-? (GR?), although the mechanism is unknown...
  43. Gassen N, Fries G, Zannas A, Hartmann J, Zschocke J, Häfner K, et al. Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine. Sci Signal. 2015;8:ra119 pubmed publisher
    Epigenetic processes, such as DNA methylation, and molecular chaperones, including FK506-binding protein 51 (FKBP51), are independently implicated in stress-related mental disorders and antidepressant drug action...
  44. Hartmann J, Wagner K, Gaali S, Kirschner A, Kozany C, Rühter G, et al. Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties. J Neurosci. 2015;35:9007-16 pubmed publisher
    ..Single nucleotide polymorphisms of the FK506 binding protein 51 (FKBP51) gene have been repeatedly associated with anxiety-related disorders and stress sensitivity...
  45. Sawamura T, Klengel T, Armario A, Jovanovic T, Norrholm S, Ressler K, et al. Dexamethasone Treatment Leads to Enhanced Fear Extinction and Dynamic Fkbp5 Regulation in Amygdala. Neuropsychopharmacology. 2016;41:832-46 pubmed publisher
    ..Dexamethasone was also associated with reduced amygdala Fkbp5 mRNA expression following EXT and after RET...
  46. Haston C, Tomko T, Godin N, Kerckhoff L, Hallett M. Murine candidate bleomycin induced pulmonary fibrosis susceptibility genes identified by gene expression and sequence analysis of linkage regions. J Med Genet. 2005;42:464-73 pubmed
    ..Combining genomics approaches of differential gene expression and sequence variation potentially identifies approximately 5% the linked genes as fibrosis susceptibility candidate genes in this mouse cross. ..
  47. Zheng D, Sabbagh J, Blair L, Darling A, Wen X, Dickey C. MicroRNA-511 Binds to FKBP5 mRNA, Which Encodes a Chaperone Protein, and Regulates Neuronal Differentiation. J Biol Chem. 2016;291:17897-906 pubmed publisher
    Single nucleotide polymorphisms in the FKBP5 gene increase the expression of the FKBP51 protein and have been associated with increased risk for neuropsychiatric disorders such as major depression and post-traumatic stress disorder...
  48. Soontornniyomkij V, Risbrough V, Young J, Wallace C, Soontornniyomkij B, Jeste D, et al. Short-term recognition memory impairment is associated with decreased expression of FK506 binding protein 51 in the aged mouse brain. Age (Dordr). 2010;32:309-22 pubmed publisher
    ..005), as was the FKBP52 IRn (p < 0.007, U test). In the frontal cortex and CA1, the FKBP51 IRn was significantly lower in impaired aged mice than in unimpaired aged mice (p < 0.01 and <0...
  49. Quintá H, Maschi D, Gomez Sanchez C, Piwien Pilipuk G, Galigniana M. Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth. J Neurochem. 2010;115:716-34 pubmed publisher
    b>FKBP51 and FKBP52 (FK506-binding protein 51 and 52) are tetratricopeptide repeat-domain immunophilins belonging to the tetratricopeptide-protein•hsp90•hsp70•p23 heterocomplex bound to steroid receptors...
  50. Wang H, Arden K, Bermingham J, Viars C, Lin W, Boyer A, et al. Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes. Genomics. 1999;57:310-5 pubmed
    ..1 (a region of conserved synteny to mouse Chromosome 5). In addition, we also found multiple SRPK-related sequences on other human chromosomes, one of which appears to correspond to a SRPK2 pseudogene on human chromosome 8. ..
  51. Romano S, Staibano S, Greco A, Brunetti A, Nappo G, Ilardi G, et al. FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential. Cell Death Dis. 2013;4:e578 pubmed publisher
    ..FK506 binding protein 51 (FKBP51), an immunophilin with a relevant role in developmental stages, is highly expressed in melanoma and correlates ..
  52. Balsevich G, Uribe A, Wagner K, Hartmann J, Santarelli S, Labermaier C, et al. Interplay between diet-induced obesity and chronic stress in mice: potential role of FKBP51. J Endocrinol. 2014;222:15-26 pubmed publisher
    ..The FK506-binding protein 51 (FKBP51, gene: Fkbp5) has been identified as a target gene implicated in the development of stress-related psychiatric ..
  53. Sevilla L, Latorre V, Sanchis A, Perez P. Epidermal inactivation of the glucocorticoid receptor triggers skin barrier defects and cutaneous inflammation. J Invest Dermatol. 2013;133:361-70 pubmed publisher
    ..Together, our results show that epidermal loss of GR provokes skin barrier defects and cutaneous inflammation...