Gene Symbol: Fkbp4
Description: FK506 binding protein 4
Alias: AL022792, AW208983, FKBP-4, FKBP-52, FKBP52, FKPB52, p59, peptidyl-prolyl cis-trans isomerase FKBP4, 52 kDa FK506-binding protein, 52 kDa FKBP, 59 kDa immunophilin, FKBP59, HBI, HSP-binding immunophilin, PPIase FKBP4, immunophilin FKBP52, rotamase
Species: mouse
Products:     Fkbp4

Top Publications

  1. Shim S, Yuan J, Kim J, Zeng W, Huang G, Milshteyn A, et al. Peptidyl-prolyl isomerase FKBP52 controls chemotropic guidance of neuronal growth cones via regulation of TRPC1 channel opening. Neuron. 2009;64:471-83 pubmed publisher
    ..We demonstrate that FKBP12 and FKBP52 catalyze cis/trans isomerization of regions of TRPC1 implicated in controlling channel opening...
  2. Warrier M, Hinds T, Ledford K, Cash H, Patel P, Bowman T, et al. Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice. Endocrinology. 2010;151:3225-36 pubmed publisher
    Although FK506-binding protein 52 (FKBP52) is an established positive regulator of glucocorticoid receptor (GR) activity, an in vivo role for FKBP52 in glucocorticoid control of metabolism has not been reported...
  3. Tranguch S, Cheung Flynn J, Daikoku T, Prapapanich V, Cox M, Xie H, et al. Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. Proc Natl Acad Sci U S A. 2005;102:14326-31 pubmed
    ..Ovarian steroid hormones estrogen and progesterone (P(4)) are the primary regulators of this process. The immunophilin FKBP52 serves as a cochaperone for steroid hormone nuclear receptors to govern appropriate hormone action in ..
  4. Blair L, Nordhues B, Hill S, Scaglione K, O Leary J, Fontaine S, et al. Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. J Clin Invest. 2013;123:4158-69 pubmed publisher
    ..Strategies aimed at attenuating FKBP51 levels or its interaction with Hsp90 have the potential to be therapeutically relevant for AD and other tauopathies. ..
  5. Davies T, Ning Y, SANCHEZ E. A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins. J Biol Chem. 2002;277:4597-600 pubmed
    ..cytoplasmic GR heterocomplex, binding of hormone-induced substitution of one immunophilin (FKBP51) for another (FKBP52), and concomitant recruitment of the transport protein dynein while leaving Hsp90 unchanged...
  6. Hartmann J, Wagner K, Dedic N, Marinescu D, Scharf S, Wang X, et al. Fkbp52 heterozygosity alters behavioral, endocrine and neurogenetic parameters under basal and chronic stress conditions in mice. Psychoneuroendocrinology. 2012;37:2009-21 pubmed publisher
    ..The co-chaperones FK506-binding protein 51 (FKBP51) and FK506-binding protein 52 (FKBP52) are components of the heat shock protein 90-receptor-heterocomplex and are functionally divergent regulators of ..
  7. Tranguch S, Wang H, Daikoku T, Xie H, Smith D, Dey S. FKBP52 deficiency-conferred uterine progesterone resistance is genetic background and pregnancy stage specific. J Clin Invest. 2007;117:1824-34 pubmed
    b>Immunophilin FKBP52 serves as a cochaperone to govern normal progesterone (P(4)) receptor (PR) function. Using Fkbp52(-/-) mice, we show intriguing aspects of uterine P(4)/PR signaling during pregnancy...
  8. Young M, Geiszler P, Pardon M. A novel role for the immunophilin FKBP52 in motor coordination. Behav Brain Res. 2016;313:97-110 pubmed publisher
    b>FKBP52 is a ubiquitously distributed immunophilin that has been associated with wide-ranging functions in cell signalling as well as hormonal and stress responses...
  9. Hong J, Kim S, Tranguch S, Smith D, Dey S. Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity. Reproduction. 2007;133:395-403 pubmed
    b>FKBP52 is a member of the FK506-binding family of immunophilins and serves as a co-chaperone for steroid hormone nuclear receptors to govern appropriate hormone action in target tissues...

More Information


  1. Echeverria P, Mazaira G, Erlejman A, Gomez Sanchez C, Piwien Pilipuk G, Galigniana M. Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta. Mol Cell Biol. 2009;29:4788-97 pubmed publisher
    ..beta and the integral nuclear pore glycoprotein Nup62 interact with hsp90, hsp70, p23, and the TPR domain proteins FKBP52 and PP5...
  2. Wolf I, Periyasamy S, Hinds T, Yong W, Shou W, SANCHEZ E. Targeted ablation reveals a novel role of FKBP52 in gene-specific regulation of glucocorticoid receptor transcriptional activity. J Steroid Biochem Mol Biol. 2009;113:36-45 pubmed publisher
    b>FKBP52 is a tetratricopeptide repeat (TPR) protein with peptidyl-prolyl isomerase activity and is found in steroid receptor complexes, including glucocorticoid receptor (GR)...
  3. Hirota Y, Burnum K, Acar N, Rabinovich G, Daikoku T, Dey S. Galectin-1 markedly reduces the incidence of resorptions in mice missing immunophilin FKBP52. Endocrinology. 2012;153:2486-93 pubmed publisher
    ..In particular, sc placement of SILASTIC implants carrying P(4) rescued implantation failure in CD1 Fkbp52(-/-) mice, but the resorption rate was substantially high at midgestation due to reduced P(4) responsiveness...
  4. O Leary J, Dharia S, Blair L, Brady S, Johnson A, Peters M, et al. A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51. PLoS ONE. 2011;6:e24840 pubmed publisher
    ..Age-dependent anxiety was also modulated by FKBP5 deletion. Therefore, drug discovery efforts focused on depleting FKBP51 levels may yield novel antidepressant therapies. ..
  5. Galigniana M, Erlejman A, Monte M, Gomez Sanchez C, Piwien Pilipuk G. The hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events. Mol Cell Biol. 2010;30:1285-98 pubmed publisher
    ..The high-molecular-weight immunophilin (IMM) FKBP52 links the MR-hsp90 complex to dynein/dynactin motors favoring the cytoplasmic transport of MR to the nucleus...
  6. Coss M, Winterstein D, Sowder R, Simek S. Molecular cloning, DNA sequence analysis, and biochemical characterization of a novel 65-kDa FK506-binding protein (FKBP65). J Biol Chem. 1995;270:29336-41 pubmed
    ..PPIase) signature domains, and, although similar in size, is distinct from FKBP52 (also identified as FKBP59, hsp56, or HBI), which contains three FKBP12-like PPIase domains...
  7. Schmitt J, Pohl J, Stunnenberg H. Cloning and expression of a mouse cDNA encoding p59, an immunophilin that associates with the glucocorticoid receptor. Gene. 1993;132:267-71 pubmed
    A cDNA encoding the homologue of the rabbit immunophilin p59 was cloned from a mouse NIH-3T3 cell line library. Antibodies were generated against the N-terminal fragment of the protein produced in bacteria...
  8. Alnemri E, Fernandes Alnemri T, Nelki D, Dudley K, DuBois G, Litwack G. Overexpression, characterization, and purification of a recombinant mouse immunophilin FKBP-52 and identification of an associated phosphoprotein. Proc Natl Acad Sci U S A. 1993;90:6839-43 pubmed
    ..Amino acid sequence analysis of this protein revealed that it is a phosphoprotein or kinase that is associated with the rFKBP-52. ..
  9. Goel M, Garcia R, Estacion M, Schilling W. Regulation of Drosophila TRPL channels by immunophilin FKBP59. J Biol Chem. 2001;276:38762-73 pubmed
    ..of one identified clone showed it to be identical to the Drosophila homolog of human FK506-binding protein, FKBP52 (previously known as FKBP59)...
  10. Quintá H, Maschi D, Gomez Sanchez C, Piwien Pilipuk G, Galigniana M. Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth. J Neurochem. 2010;115:716-34 pubmed publisher
    FKBP51 and FKBP52 (FK506-binding protein 51 and 52) are tetratricopeptide repeat-domain immunophilins belonging to the tetratricopeptide-protein•hsp90•hsp70•p23 heterocomplex bound to steroid receptors...
  11. Ott M, Litzenburger U, Rauschenbach K, Bunse L, Ochs K, Sahm F, et al. Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway. Glia. 2015;63:78-90 pubmed publisher
    ..TDO inhibition was dependent on the immunophilin FKBP52, whose FK1 domain physically interacted with the glucocorticoid receptor as demonstrated by bimolecular ..
  12. Martinez N, Chang H, Borrajo J, Gregory R. The co-chaperones Fkbp4/5 control Argonaute2 expression and facilitate RISC assembly. RNA. 2013;19:1583-93 pubmed publisher
    ..Here we identify the co-chaperones Fkbp4 and Fkbp5 as Ago2-associated proteins in mouse embryonic stem cells...
  13. Chen H, Yong W, Hinds T, Yang Z, Zhou Y, SANCHEZ E, et al. Fkbp52 regulates androgen receptor transactivation activity and male urethra morphogenesis. J Biol Chem. 2010;285:27776-84 pubmed publisher
    ..Recent studies have shown that male mice with targeted ablation of FK506-binding protein-52 (Fkbp52) develop hypospadias, most likely due to actions of Fkbp52 as a molecular co-chaperone of the androgen receptor (..
  14. Cox M, Riggs D, Hessling M, Schumacher F, Buchner J, Smith D. FK506-binding protein 52 phosphorylation: a potential mechanism for regulating steroid hormone receptor activity. Mol Endocrinol. 2007;21:2956-67 pubmed
    ..Previous cellular studies demonstrated that FKBP52 can potentiate receptor function...
  15. Kuhner M, Goodenow R. DNA sequences of mouse H-2 and Qa genes. Immunogenetics. 1989;30:458-64 pubmed
  16. Yang Z, Wolf I, Chen H, Periyasamy S, Chen Z, Yong W, et al. FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor A isoform. Mol Endocrinol. 2006;20:2682-94 pubmed
    FK506-binding protein 52 (FKBP52) is a tetratricopeptide repeat protein that associates with steroid receptors in complexes containing heat shock protein 90...
  17. Yong W, Yang Z, Periyasamy S, Chen H, Yucel S, Li W, et al. Essential role for Co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology. J Biol Chem. 2007;282:5026-36 pubmed
    b>Fkbp52 and Fkbp51 are tetratricopeptide repeat proteins found in steroid receptor complexes, and Fkbp51 is an androgen receptor (AR) target gene...
  18. Haraguchi H, Saito Fujita T, Hirota Y, Egashira M, Matsumoto L, Matsuo M, et al. MicroRNA-200a locally attenuates progesterone signaling in the cervix, preventing embryo implantation. Mol Endocrinol. 2014;28:1108-17 pubmed publisher
    ..These findings may point toward not only the physiological but also the pathological basis of the cervical milieu in embryo implantation. ..
  19. Hirota Y, Tranguch S, Daikoku T, Hasegawa A, Osuga Y, Taketani Y, et al. Deficiency of immunophilin FKBP52 promotes endometriosis. Am J Pathol. 2008;173:1747-57 pubmed publisher
    ..Deletion of Fkbp52, an immunophilin cochaperone for PR, results in uterine-specific P(4) resistance in mice, creating an opportunity ..
  20. Hirota Y, Acar N, Tranguch S, Burnum K, Xie H, Kodama A, et al. Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress. Proc Natl Acad Sci U S A. 2010;107:15577-82 pubmed publisher
    Immunophilin FK506-binding protein 52 (FKBP52) is a cochaperone that binds to the progesterone receptor (PR) to optimize progesterone (P(4))-PR signaling...
  21. Daikoku T, Tranguch S, Friedman D, Das S, Smith D, Dey S. Proteomic analysis identifies immunophilin FK506 binding protein 4 (FKBP52) as a downstream target of Hoxa10 in the periimplantation mouse uterus. Mol Endocrinol. 2005;19:683-97 pubmed
    ..Using the proteomics approach of difference gel electrophoresis, we have identified an immunophilin FKBP52 (FK506 binding protein 4) as one of the Hoxa10-mediated signaling molecules in the uterus...
  22. De Leon J, Iwai A, Feau C, Garcia Y, Balsiger H, Storer C, et al. Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells. Proc Natl Acad Sci U S A. 2011;108:11878-83 pubmed publisher
    ..The 52 kDa FK506 binding protein (FKBP52) is an important positive regulator of AR in cellular and whole animal models and represents an ..
  23. Cheung Flynn J, Prapapanich V, Cox M, Riggs D, Suarez Quian C, Smith D. Physiological role for the cochaperone FKBP52 in androgen receptor signaling. Mol Endocrinol. 2005;19:1654-66 pubmed
    ..To help fill this gap, we targeted for disruption the mouse gene for the 52-kDa FK506 binding protein, FKBP52, a 90-kDa heat shock protein (Hsp90)-binding immunophilin found in steroid receptor complexes...
  24. Riggs D, Cox M, Tardif H, Hessling M, Buchner J, Smith D. Noncatalytic role of the FKBP52 peptidyl-prolyl isomerase domain in the regulation of steroid hormone signaling. Mol Cell Biol. 2007;27:8658-69 pubmed
    ..transactivation by several of the steroid hormone receptors is potentiated by the Hsp90-associated cochaperone FKBP52, although not by the closely related FKBP51...