FKBP23

Summary

Gene Symbol: FKBP23
Description: FK506 binding protein 7
Alias: 23kDa, FKBP-7, FKBP23, peptidyl-prolyl cis-trans isomerase FKBP7, 23 kDa FK506-binding protein, 23 kDa FKBP, FKBP-23, PPIase FKBP7, rotamase
Species: mouse
Products:     FKBP23

Top Publications

  1. Thach D, Kleeberger S, Tucker P, Griffin D. Genetic control of neuroadapted sindbis virus replication in female mice maps to chromosome 2 and associates with paralysis and mortality. J Virol. 2001;75:8674-80 pubmed
    ..8 to 0.9). These results indicate that mortality, paralysis, and viral RNA levels are related complex traits and that Nsv1 controls early viral load and determines the likelihood of paralysis and death. ..
  2. Nakamura T, Yabe D, Kanazawa N, Tashiro K, Sasayama S, Honjo T. Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability. Genomics. 1998;54:89-98 pubmed
    We have identified and characterized a cDNA encoding a novel FK506-binding protein (FKBP), named FKBP23, from mouse heart by the signal sequence trap method...
  3. Wang Y, Han R, Wu D, Li J, Chen C, Ma H, et al. The binding of FKBP23 to BiP modulates BiP's ATPase activity with its PPIase activity. Biochem Biophys Res Commun. 2007;354:315-20 pubmed
    ..In this study, we demonstrate the ability of mFKBP23 to modulate the ATPase activity of BiP, and that the bound mFKBP23, but not the free mFKBP23, can suppress the ATPase activity of mBiP through its PPIase activity. ..
  4. Feng M, Gu C, Ma S, Wang Y, Liu H, Han R, et al. Mouse FKBP23 mediates conformer-specific functions of BiP by catalyzing Pro117 cis/trans isomerization. Biochem Biophys Res Commun. 2011;408:537-40 pubmed publisher
    ..In previous work, we revealed that mouse FKBP23 binds immunoglobulin binding protein (BiP), the major heat shock protein (Hsp) 70 chaperone in the ER, and the ..
  5. Zhang X, Wang Y, Li H, Zhang W, Wu D, Mi H. The mouse FKBP23 binds to BiP in ER and the binding of C-terminal domain is interrelated with Ca2+ concentration. FEBS Lett. 2004;559:57-60 pubmed
    ..By high concentration of Ca(2+) this binding cannot be detected. Furthermore, the Ca(2+)-regulated binding of mFKBP23 and mBiP in ER can be detected by means of co-immunoprecipitation. ..
  6. Chen C, Ma H, Wang Y, Mi H. Binding of FKBP23 to BiP in ER shown by gel filtration chromatography. Z Naturforsch C. 2007;62:133-7 pubmed
    b>FKBP23 was found in mouse endoplasmic reticulum (ER) in 1998. It consists of an N-terminal peptidyl-prolyl cis/trans isomerase (PPIase) domain and a C-terminal domain with Ca2+ binding sites...