| ficolin BGene Symbol: ficolin B Description: ficolin B Alias: Fcn2, ficolin-2, L-ficolin, collagen/fibrinogen domain-containing protein 2, ficolin-beta Species: mouse Endo Y, Takahashi M, Iwaki D, Ishida Y, Nakazawa N, Kodama T, et al. Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection. J Immunol. 2012;189:5860-6 pubmed publisher ..The ficolin A (FcnA)-deficient (Fcna(-/-)) and FcnA/ficolin B double-deficient (Fcna(-/-)b(-/-)) mice lacked FcnA-mediated complement activation in the sera, because of the .. Ohashi T, Erickson H. Oligomeric structure and tissue distribution of ficolins from mouse, pig and human. Arch Biochem Biophys. 1998;360:223-32 pubmed ..We have identified a second mouse ficolin gene, ficolin B, which means that pig and mouse each have two ficolin genes, and human has three... Endo Y, Liu Y, Kanno K, Takahashi M, Matsushita M, Fujita T. Identification of the mouse H-ficolin gene as a pseudogene and orthology between mouse ficolins A/B and human L-/M-ficolins. Genomics. 2004;84:737-44 pubmed ..The mouse ficolin A gene was located far from the ficolin B gene on chromosome 2, whereas the human L-ficolin and M-ficolin genes were close in the region homologous to the .. Endo Y, Nakazawa N, Liu Y, Iwaki D, Takahashi M, Fujita T, et al. Carbohydrate-binding specificities of mouse ficolin A, a splicing variant of ficolin A and ficolin B and their complex formation with MASP-2 and sMAP. Immunogenetics. 2005;57:837-44 pubmed ..Two types of ficolins have been identified in mice, ficolin A, and ficolin B. However, their structure and function are not fully understood... Liu Y, Endo Y, Homma S, Kanno K, Yaginuma H, Fujita T. Ficolin A and ficolin B are expressed in distinct ontogenic patterns and cell types in the mouse. Mol Immunol. 2005;42:1265-73 pubmed ..b>Ficolin B exhibited a distinct ontogeny pattern that switched from embryonic liver to postnatal bone marrow and spleen... Hunold K, Weber Steffens D, Runza V, Jensenius J, Männel D. Functional analysis of mouse ficolin-B and detection in neutrophils. Immunobiology. 2012;217:982-5 pubmed publisher ..These results identify mouse ficolin-B as a functional member of the ficolin family activating complement via the lectin pathway. .. Endo Y, Iwaki D, Ishida Y, Takahashi M, Matsushita M, Fujita T. Mouse ficolin B has an ability to form complexes with mannose-binding lectin-associated serine proteases and activate complement through the lectin pathway. J Biomed Biotechnol. 2012;2012:105891 pubmed publisher ..However, the ability of murine ficolin B, a homologue of human M-ficolin, to perform this function is still controversial... Weber Steffens D, Hunold K, Kürschner J, Martinez S, Elumalai P, Schmidt D, et al. Immature mouse granulocytic myeloid cells are characterized by production of ficolin-B. Mol Immunol. 2013;56:488-96 pubmed publisher ..This study shows that ficolin-B is stored in and set free from immature granulocytic myeloid cells indicating a role in the early infection-induced cellular response of these inflammatory cells. .. Luo F, Sun X, Wang Y, Wang Q, Wu Y, Pan Q, et al. Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans. PLoS ONE. 2013;8:e73859 pubmed publisher ..Our data provide a new immunotherapeutic strategy against TB based on the innate immune molecule ficolin-2 and indicate that ficolin-2 insufficiency is associated with higher susceptibility to infection in humans. ..
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