ficolin A


Gene Symbol: ficolin A
Description: ficolin A
Alias: Fcn1, ficolin-1, M-ficolin, collagen/fibrinogen domain-containing protein 1, ficolin-alpha
Species: mouse
Products:     ficolin A

Top Publications

  1. Ohashi T, Erickson H. Oligomeric structure and tissue distribution of ficolins from mouse, pig and human. Arch Biochem Biophys. 1998;360:223-32 pubmed
    ..We conclude that mouse plasma ficolin corresponds to the recently described ficolin A. We have identified a second mouse ficolin gene, ficolin B, which means that pig and mouse each have two ficolin ..
  2. Pan Q, Chen H, Wang F, Jeza V, Hou W, Zhao Y, et al. L-ficolin binds to the glycoproteins hemagglutinin and neuraminidase and inhibits influenza A virus infection both in vitro and in vivo. J Innate Immun. 2012;4:312-24 pubmed publisher
    ..a mouse model of influenza A virus infection to demonstrate that the administration of exogenous L-ficolin or ficolin A (FCNA - an L-ficolin-like molecule in the mouse) is protective against the virus...
  3. Liu Y, Endo Y, Homma S, Kanno K, Yaginuma H, Fujita T. Ficolin A and ficolin B are expressed in distinct ontogenic patterns and cell types in the mouse. Mol Immunol. 2005;42:1265-73 pubmed
    ..RT-PCR analysis showed that the expression pattern of ficolin A expression was closely similar to that of Masps, suggesting that these molecules may function in coordination as ..
  4. Kwon S, Kim M, Kim D, Lee K, Choi S, Park J, et al. Identification of a functionally relevant signal peptide of mouse ficolin A. J Biochem Mol Biol. 2007;40:532-8 pubmed
    Mouse ficolin A is a plasma protein with lectin activity, and plays a role in host defense by binding carbohydrates, especially GlcNAc, on microorganisms...
  5. Fujimori Y, Harumiya S, Fukumoto Y, Miura Y, Yagasaki K, Tachikawa H, et al. Molecular cloning and characterization of mouse ficolin-A. Biochem Biophys Res Commun. 1998;244:796-800 pubmed
    ..Immunoblot analysis using an anti-mouse ficolin-A antiserum showed that mouse ficolin-A is a plasma protein with binding activity to elastin and GlcNAc. ..
  6. Endo Y, Takahashi M, Iwaki D, Ishida Y, Nakazawa N, Kodama T, et al. Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection. J Immunol. 2012;189:5860-6 pubmed publisher
    ..To define the specific role of ficolin in vivo, we generated model mice deficient in ficolins. The ficolin A (FcnA)-deficient (Fcna(-/-)) and FcnA/ficolin B double-deficient (Fcna(-/-)b(-/-)) mice lacked FcnA-mediated ..
  7. Endo Y, Liu Y, Kanno K, Takahashi M, Matsushita M, Fujita T. Identification of the mouse H-ficolin gene as a pseudogene and orthology between mouse ficolins A/B and human L-/M-ficolins. Genomics. 2004;84:737-44 pubmed
    ..The mouse homologue of the H-ficolin gene was identified as a pseudogene on chromosome 4. The mouse ficolin A gene was located far from the ficolin B gene on chromosome 2, whereas the human L-ficolin and M-ficolin genes ..
  8. Genster N, Præstekjær Cramer E, Rosbjerg A, Pilely K, Cowland J, Garred P. Ficolins Promote Fungal Clearance in vivo and Modulate the Inflammatory Cytokine Response in Host Defense against Aspergillus fumigatus. J Innate Immun. 2016;8:579-588 pubmed
    ..fumigatus-mediated complement activation in ficolin knockout mice and wild-type mice. In conclusion, this study demonstrates that ficolins are important in initial innate host defense against A. fumigatus infections in vivo. ..
  9. Yang Y, Zhou Y, Hu J, Luo F, Xie Y, Shen Y, et al. Ficolin-A/2, acting as a new regulator of macrophage polarization, mediates the inflammatory response in experimental mouse colitis. Immunology. 2017;151:433-450 pubmed publisher
    ..Hence, our data suggest that FCN-A/2 may be used as a novel therapeutic target for IBD. ..

More Information


  1. Endo Y, Nakazawa N, Iwaki D, Takahashi M, Matsushita M, Fujita T. Interactions of ficolin and mannose-binding lectin with fibrinogen/fibrin augment the lectin complement pathway. J Innate Immun. 2010;2:33-42 pubmed publisher
    ..An ELISA revealed that recombinant mouse ficolin A (rFcnA), rMBL-A and rMBL-C bind to fibrinogen in a dose-dependent manner...
  2. Banda N, Takahashi M, Takahashi K, Stahl G, Hyatt S, Glogowska M, et al. Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement. Mol Immunol. 2011;49:281-9 pubmed publisher
    ..We conclude that MASP-1 does not require binding to MBL-A, MBL-C, or FCN-A to activate the AP. MASP-1 may cleave pro-Df into mature Df through binding to FCN-B or to an unknown protein, or may function as an unbound soluble protein. ..
  3. Luo F, Sun X, Wang Y, Wang Q, Wu Y, Pan Q, et al. Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans. PLoS ONE. 2013;8:e73859 pubmed publisher
    ..Our data provide a new immunotherapeutic strategy against TB based on the innate immune molecule ficolin-2 and indicate that ficolin-2 insufficiency is associated with higher susceptibility to infection in humans. ..
  4. Ding Q, Shen Y, Li D, Yang J, Yu J, Yin Z, et al. Ficolin-2 triggers antitumor effect by activating macrophages and CD8+ T cells. Clin Immunol. 2017;183:145-157 pubmed publisher
    ..Our findings provide a new therapeutic strategy for tumors based on the triggering of immune-mediated antitumor effect by ficolin-2. ..
  5. Endo Y, Nakazawa N, Liu Y, Iwaki D, Takahashi M, Fujita T, et al. Carbohydrate-binding specificities of mouse ficolin A, a splicing variant of ficolin A and ficolin B and their complex formation with MASP-2 and sMAP. Immunogenetics. 2005;57:837-44 pubmed
    ..Two types of ficolins have been identified in mice, ficolin A, and ficolin B. However, their structure and function are not fully understood...
  6. Hummelshøj T, Ma Y, Munthe Fog L, Bjarnsholt T, Moser C, Skjoedt M, et al. The interaction pattern of murine serum ficolin-A with microorganisms. PLoS ONE. 2012;7:e38196 pubmed publisher
    ..In contrast, ficolin-3 did not bind to any of the investigated microorganisms and the anti-microbial role of ficolin-3 still remains elusive. ..
  7. Ali Y, Lynch N, Haleem K, Fujita T, Endo Y, Hansen S, et al. The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. PLoS Pathog. 2012;8:e1002793 pubmed publisher
    ..Using sera from mice and humans with defined complement deficiencies, we demonstrate that mouse ficolin A, human L-ficolin, and collectin 11 in both species, but not mannan-binding lectin (MBL), are the pattern ..
  8. Bidula S, Kenawy H, Ali Y, Sexton D, Schwaeble W, Schelenz S. Role of ficolin-A and lectin complement pathway in the innate defense against pathogenic Aspergillus species. Infect Immun. 2013;81:1730-40 pubmed publisher
    ..However, it appears that other immune pattern recognition molecules, i.e., those of the collectin MBL-C, are involved in the Aspergillus-lectin complement pathway activation rather than ficolin-A. ..