Fgr

Summary

Gene Symbol: Fgr
Description: FGR proto-oncogene, Src family tyrosine kinase
Alias: tyrosine-protein kinase Fgr, Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog, p55-Fgr, proto-oncogene c-Fgr, proto-oncogene tyrosine-protein kinase Fgr
Species: mouse
Products:     Fgr

Top Publications

  1. Giagulli C, Ottoboni L, Caveggion E, Rossi B, Lowell C, Constantin G, et al. The Src family kinases Hck and Fgr are dispensable for inside-out, chemoattractant-induced signaling regulating beta 2 integrin affinity and valency in neutrophils, but are required for beta 2 integrin-mediated outside-in signaling involved in sustai. J Immunol. 2006;177:604-11 pubmed
    ..Addressing inside-out and outside-in signaling in hck(-/-)fgr(-/-) neutrophils, we found that Hck and Fgr do not regulate chemoattractant-induced activation of beta(2) integrin ..
  2. Mocsai A, Ligeti E, Lowell C, Berton G. Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck. J Immunol. 1999;162:1120-6 pubmed
    ..Double knockout hck-/- fgr-/- PMN adherent to collagen or fibrinogen failed to release lactoferrin in response to TNF-alpha but responded to ..
  3. Zhang H, Meng F, Chu C, Takai T, Lowell C. The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B. Immunity. 2005;22:235-46 pubmed
    ..However, neutrophils derived from hck-/-fgr-/- mice and dendritic cells (DCs) from fgr-/- animals manifested significantly higher intracellular signaling (Ca2+ ..
  4. Yi T, Willman C. Cloning of the murine c-fgr proto-oncogene cDNA and induction of c-fgr expression by proliferation and activation factors in normal bone marrow-derived monocytic cells. Oncogene. 1989;4:1081-7 pubmed
    Normal murine bone marrow-derived monocytic cells were found to contain transcripts for c-fgr and hck, two members of the src family of proto-oncogene tyrosine kinases...
  5. Fitzer Attas C, Lowry M, Crowley M, Finn A, Meng F, DeFranco A, et al. Fcgamma receptor-mediated phagocytosis in macrophages lacking the Src family tyrosine kinases Hck, Fgr, and Lyn. J Exp Med. 2000;191:669-82 pubmed
    ..marrow-derived macrophages from mutant mice lacking the major Src family kinases expressed in these cells, Hck, Fgr, and Lyn...
  6. Mocsai A, Zhou M, Meng F, Tybulewicz V, Lowell C. Syk is required for integrin signaling in neutrophils. Immunity. 2002;16:547-58 pubmed
    ..Thus, integrins use different signaling mechanisms to support migration and adherent activation. ..
  7. Meng F, Lowell C. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J Exp Med. 1997;185:1661-70 pubmed
    ..an increasing amount of evidence suggests that protein tyrosine kinases especially the Src-family kinases Hck, Fgr, and Lyn, play important roles in LPS signaling...
  8. Zarbock A, Abram C, Hundt M, Altman A, Lowell C, Ley K. PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med. 2008;205:2339-47 pubmed publisher
    ..E-selectin-mediated phosphorylation of Syk and slow rolling was abolished in neutrophils from fgr(-/-) or hck(-/-) lyn(-/-) fgr(-/-) mice...
  9. Fumagalli L, Zhang H, Baruzzi A, Lowell C, Berton G. The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine. J Immunol. 2007;178:3874-85 pubmed
    ..Deficiency of the Src family kinases Hck and Fgr have previously been found to regulate fMLP-induced degranulation...

Scientific Experts

More Information

Publications62

  1. Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner D, et al. Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity. 2006;25:271-83 pubmed
    ..These data suggest that Mac-1 engagement of complement activates tyrosine kinases to promote elastase-dependent blood vessel injury in vivo. ..
  2. Mocsai A, Abram C, Jakus Z, Hu Y, Lanier L, Lowell C. Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol. 2006;7:1326-33 pubmed
    ..Our data show that integrin signaling for the activation of cellular responses in neutrophils and macrophages proceeds by an immunoreceptor-like mechanism. ..
  3. Lowell C, Soriano P, Varmus H. Functional overlap in the src gene family: inactivation of hck and fgr impairs natural immunity. Genes Dev. 1994;8:387-98 pubmed
    We have generated mice with targeted disruptions of the src-like genes hck and fgr to assess the role of these kinases in myeloid cell development and function...
  4. Jakus Z, Simon E, Frommhold D, Sperandio M, Mócsai A. Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis. J Exp Med. 2009;206:577-93 pubmed publisher
    ..These results identify PLCgamma2 as a critical player of integrin and Fc receptor-mediated neutrophil functions and the neutrophil-mediated effector phase of autoimmune arthritis. ..
  5. Yago T, Shao B, Miner J, Yao L, Klopocki A, Maeda K, et al. E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling. Blood. 2010;116:485-94 pubmed publisher
    ..Previous studies identified P-selectin glycoprotein ligand-1 (PSGL-1) as the essential E-selectin ligand and Fgr as the only SFK that initiate signaling to slow rolling...
  6. Sarantos M, Zhang H, Schaff U, Dixit N, Hayenga H, Lowell C, et al. Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase. J Immunol. 2008;181:8660-9 pubmed
    ..We conclude that dimeric bond clusters of LFA-1/ICAM-1 provide a key outside-in signal for orienting cytoskeletal dynamics that direct PMN extravasation at sites of inflammation. ..
  7. Vicentini L, Mazzi P, Caveggion E, Continolo S, Fumagalli L, Lapinet Vera J, et al. Fgr deficiency results in defective eosinophil recruitment to the lung during allergic airway inflammation. J Immunol. 2002;168:6446-54 pubmed
    Using a mouse model of allergic lung inflammation, we found that mice deficient of Fgr, a Src family tyrosine kinase highly expressed in myelomonocytic cells, fail to develop lung eosinophilia in response to repeated challenge with ..
  8. Pereira S, Zhou M, Mocsai A, Lowell C. Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases. J Immunol. 2001;166:4115-23 pubmed
    ..Neutrophils derived from hck(-/-)fgr(-/-)lyn(-/-) triple-knockout or hck(-/-)fgr(-/-) double-knockout mice failed to undergo respiratory burst when ..
  9. Lowell C, Fumagalli L, Berton G. Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions. J Cell Biol. 1996;133:895-910 pubmed
    ..To directly test whether these functional responses are dependent on the Src family kinases p59/61hck and p58c-fgr, we examined adhesion-dependent respiratory burst in PMNs isolated from hck -/-, fgr -/-, and hck -/- fgr -/- ..
  10. Lowell C, Niwa M, Soriano P, Varmus H. Deficiency of the Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood. 1996;87:1780-92 pubmed
    Expression of the Src-family kinases--Src, Hck, and Fgr--increases dramatically during myeloid cell development...
  11. Suen P, Ilic D, Caveggion E, Berton G, Damsky C, Lowell C. Impaired integrin-mediated signal transduction, altered cytoskeletal structure and reduced motility in Hck/Fgr deficient macrophages. J Cell Sci. 1999;112 ( Pt 22):4067-78 pubmed
    ..in integrin signal transduction, we have examined the adhesive properties of macrophages isolated from hck-/-fgr-/- double knockout mice which lack two of the three predominant Src-family kinases expressed in myeloid cells...
  12. Crowley M, Costello P, Fitzer Attas C, Turner M, Meng F, Lowell C, et al. A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. J Exp Med. 1997;186:1027-39 pubmed
    ..derived from mice deficient for the three members of the Src-family of kinases expressed in these cells, Hck, Fgr, and Lyn, exhibited poor Syk activation upon FcgammaR engagement, accompanied by a delay in FcgammaR-mediated ..
  13. Meng F, Lowell C. A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration. EMBO J. 1998;17:4391-403 pubmed
    ..the p120(c-cbl) (Cbl) protein rapidly becomes tyrosine phosphorylated and associated with the Src-family kinases Fgr and Lyn...
  14. Nelson M, Christmann B, Werner J, Metz A, Trevor J, Lowell C, et al. IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina. J Immunol. 2011;186:2372-81 pubmed publisher
    We have recently reported that mice deficient in the myeloid Src-family tyrosine kinases Hck, Fgr, and Lyn (Src triple knockout [TKO]) had augmented innate lung clearance of Pneumocystis murina that correlated with a higher ability of ..
  15. Christy B, Sanders L, Lau L, Copeland N, Jenkins N, Nathans D. An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. Proc Natl Acad Sci U S A. 1991;88:1815-9 pubmed
    ..On the basis of its structural and functional similarity to Id, we suggest that HLH462 may inhibit the activities of helix-loop-helix transcription factors during the cellular growth response and during development. ..
  16. Goodwin R, Anderson D, Jerzy R, Davis T, Brannan C, Copeland N, et al. Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor. Mol Cell Biol. 1991;11:3020-6 pubmed
    ..The murine cDNAs were further used to determine the chromosomal locations of the TNF receptor genes. They are not linked, in contrast to the ligands, and map to chromosomes 4 (type 1) and 6 (type 2). ..
  17. Zimmerman J, Bui Q, Steingrimsson E, Nagle D, Fu W, Genin A, et al. Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene. Genome Res. 1997;7:128-41 pubmed
    ..Our findings support the notion that several families of genes (Pax-6/eyeless, Six-3/sine oculis, and Eya) play related and critical roles in the eye for both files and vertebrates. ..
  18. Serfas M, Tyner A. HNF-1 alpha and HNF-1 beta expression in mouse intestinal crypts. Am J Physiol. 1993;265:G506-13 pubmed
    ..Although HNF-1 is necessary for transcription of the AFP gene, other factors must be involved in eliciting the cell type-specific pattern of AFP expression in the intestine...
  19. Gout I, Dhand R, Hiles I, Fry M, Panayotou G, Das P, et al. The GTPase dynamin binds to and is activated by a subset of SH3 domains. Cell. 1993;75:25-36 pubmed
  20. Lee J, Lowell C, Lemay D, Youn H, Rhee S, Sohn K, et al. The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4. Biochem Pharmacol. 2005;70:1231-40 pubmed
    ..nitric oxide synthase (iNOS) induced by LPS were not affected in macrophages deficient in three STKs (Lyn, Hck, and Fgr)...
  21. Rivero Lezcano O, Sameshima J, Marcilla A, Robbins K. Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene. J Biol Chem. 1994;269:17363-6 pubmed
    ..Moreover, it was possible to demonstrate an in vivo association between p47nck and p120c-cbl in HL60 cells. These findings suggest that proteins containing SH3 elements regulate Cbl function. ..
  22. Tronick S, Popescu N, Cheah M, Swan D, Amsbaugh S, Lengel C, et al. Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family. Proc Natl Acad Sci U S A. 1985;82:6595-9 pubmed
    ..virus (GR-FeSV) consists of a gamma-actin- and a tyrosine-specific protein kinase-encoding sequence designated v-fgr. By utilizing a v-fgr probe, it was possible to detect related sequences present at low copy number in DNAs of a ..
  23. Evangelista V, Pamuklar Z, Piccoli A, Manarini S, Dell Elba G, Pecce R, et al. Src family kinases mediate neutrophil adhesion to adherent platelets. Blood. 2007;109:2461-9 pubmed
    ..PMNs from alphaMbeta2(-/-), hck(-/-)fgr(-/-), and hck(-/-)fgr(-/-)lyn(-/-) mice had an impaired capacity to adhere with activated platelets in suspension...
  24. Akilesh S, Dudley M, Eden P, Roopenian D. Efficient chromosomal mapping of a methylcholanthrene-induced tumor antigen by CTL immunoselection. J Immunol. 2001;167:5143-9 pubmed
    ..1 cM interval on chromosome 4. This region of the mouse genome is rich in tumor-modifier genes and this positioning of Ram1 may thus provide insight into the genetic basis of 3-methycholanthrene-induced tumor Ags. ..
  25. Threadgill D, Threadgill D, Moll Y, Weiss J, Zhang N, Davey H, et al. Syntenic assignment of human chromosome 1 homologous loci in the bovine. Genomics. 1994;22:626-30 pubmed
    ..component receptor 2 (CR2), phosphofructokinase muscle type (PFKM), Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog (FGR), alpha fucosidase (FUCA1), G-protein beta 1 subunit (GNB1), alpha 1A amylase, (AMY1), the ..
  26. Shao B, Yago T, Setiadi H, Wang Y, Mehta D souza P, Fu J, et al. O-glycans direct selectin ligands to lipid rafts on leukocytes. Proc Natl Acad Sci U S A. 2015;112:8661-6 pubmed publisher
    ..Preassociation of these glycoproteins with rafts is required for signaling but not for movement to uropods. ..
  27. Wetzel D, Rhodes E, Li S, MCMAHON PRATT D, Koleske A. The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection. J Cell Sci. 2016;129:3130-43 pubmed publisher
    ..inhibitors and primary macrophages lacking specific Src family kinases, we now demonstrate that the Hck, Fgr and Lyn kinases are also necessary for amastigote uptake by macrophages...
  28. Lewin H, Beever J, Da Y, Hines H, Faulkner D. The bovine B and C blood group systems are not likely to be the orthologues of human RH: an interesting twist in the comparative map. Anim Genet. 1994;25 Suppl 1:13-8 pubmed
    ..blood typing and restriction fragment length polymorphism (RFLP) analysis of four loci linked to RH on HSA1; PGD, FGR, ALPL and FUCA1. Four sires with a total of 255 half-sib offspring were used for the linkage analysis...
  29. King F, Cole M. Molecular cloning and sequencing of the murine c-fgr gene. Oncogene. 1990;5:337-44 pubmed
    The c-fgr gene is a member of the tyrosine kinase family of proto-oncogenes and is expressed exclusively in hemopoietic cells...
  30. Majeed M, Caveggion E, Lowell C, Berton G. Role of Src kinases and Syk in Fcgamma receptor-mediated phagocytosis and phagosome-lysosome fusion. J Leukoc Biol. 2001;70:801-11 pubmed
    ..Similar studies with macrophages lacking the Src family kinases Hck, Fgr, and Lyn showed that these kinases are not required for phagocytosis but that they enhance the rate of particle ..
  31. Rinke De Wit T, Izon D, Revilla C, Oosterwegel M, Bakker A, van Ewijk W, et al. Expression of tyrosine kinase gene in mouse thymic stromal cells. Int Immunol. 1996;8:1787-95 pubmed
    ..These data provide the first example of a receptor PTK in TSC and open new approaches to study the regulation of TSC differentiation. ..
  32. Ceci J, Siracusa L, Jenkins N, Copeland N. A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenes. Genomics. 1989;5:699-709 pubmed
    ..of viral integration have been assigned regional locations on chromosome 4 including Mos, Lyn, Jun, Lmyc, Lck, Fgr, and Dsi-1. Additional loci mapped in this study to chromosome 4 were Tsha, Mup-1, Rrm2-ps1, Ifa, and Anf...
  33. Ito Y, Seto Y, Brannan C, Copeland N, Jenkins N, Fukunaga R, et al. Structural analysis of the functional gene and pseudogene encoding the murine granulocyte colony-stimulating-factor receptor. Eur J Biochem. 1994;220:881-91 pubmed
    ..The processed pseudogene has, in its most 5' region, a sequence of approximately 200 bp that is highly related to the DNA sequence approximately 1.2 kbp upstream of the cap site of the functional gene. ..
  34. Stadtmann A, Germena G, Block H, Boras M, Rossaint J, Sundd P, et al. The PSGL-1-L-selectin signaling complex regulates neutrophil adhesion under flow. J Exp Med. 2013;210:2171-80 pubmed publisher
    ..We conclude that this is a signaling complex specialized for sensing adhesion under flow. ..
  35. Lee J, Kim J, Kim D, Kim H, Park H, Park D, et al. The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice. J Immunol. 2011;187:1807-15 pubmed publisher
    ..and Hck are reported to be positive regulators, but little is known about the roles of other Src kinases, including Fgr, in mast cells. In this study, we define the role of Fgr...
  36. Yi T, Li J, Chen H, Wu J, An J, Xu Y, et al. Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses. Immunity. 2015;43:764-75 pubmed publisher
  37. Gresham H, Dale B, Potter J, Chang P, Vines C, Lowell C, et al. Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr. J Exp Med. 2000;191:515-28 pubmed
    ..To pursue negative regulation of phagocytosis, we assessed the effect of the Src kinase family member, Fgr, on opsonin-dependent phagocytosis by mouse macrophages...
  38. Sun D, Chang A, Jenkins N, Gilbert D, Copeland N, Chang N. Identification, molecular characterization, and chromosomal localization of the cDNA encoding a novel leucine zipper motif-containing protein. Genomics. 1996;36:54-62 pubmed
    ..Interspecific backcross analyses have mapped Luzp to mouse chromosome 4 in proximity to Gpcr14. Comparative mapping data suggest that the human homolog of Luzp will map to human chromosome 1p36. ..
  39. Paul R, Obermaier B, Van Ziffle J, Angele B, Pfister H, Lowell C, et al. Myeloid Src kinases regulate phagocytosis and oxidative burst in pneumococcal meningitis by activating NADPH oxidase. J Leukoc Biol. 2008;84:1141-50 pubmed publisher
    ..Myeloid Src family kinases (SFKs) p59/61(hck) (Hck), p58(c-fgr) (Fgr), and p53/56(lyn) (Lyn) are known to control integrin beta(2) signal transduction and FcgammaR-mediated ..
  40. Acin Perez R, Carrascoso I, Baixauli F, Roche Molina M, Latorre Pellicer A, Fernandez Silva P, et al. ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use. Cell Metab. 2014;19:1020-33 pubmed publisher
    ..This phosphorylation is mediated by the tyrosine-kinase Fgr, which is activated by hydrogen peroxide...
  41. Fumagalli L, Campa C, Germena G, Lowell C, Hirsch E, Berton G. Class I phosphoinositide-3-kinases and SRC kinases play a nonredundant role in regulation of adhesion-independent and -dependent neutrophil reactive oxygen species generation. J Immunol. 2013;190:3648-60 pubmed publisher
    ..using human neutrophils treated with inhibitory compounds or murine neutrophils deficient of PI3K? or Hck, Fgr, and Lyn...
  42. Alexandropoulos K, Cheng G, Baltimore D. Proline-rich sequences that bind to Src homology 3 domains with individual specificities. Proc Natl Acad Sci U S A. 1995;92:3110-4 pubmed
    ..The rules governing in vivo usage of particular sites by particular SH3 domains are not clear, but one binding orientation may be more specific than another. ..
  43. Baruzzi A, Iacobucci I, Soverini S, Lowell C, Martinelli G, Berton G. c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration. FEBS Lett. 2010;584:15-21 pubmed publisher
    ..We found that the SFK members Hck and c-Fgr regulate tyrosine phosphorylation of c-Abl and c-Abl associates with beta1 integrin-bound Hck or c-Fgr in murine ..
  44. Scapini P, Morini M, Tecchio C, Minghelli S, Di Carlo E, Tanghetti E, et al. CXCL1/macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-A. J Immunol. 2004;172:5034-40 pubmed
    ..In this study, we demonstrate that mice deficient in the src family kinases, Hck and Fgr (hck(-/-)fgr(-/-)), are unable to develop an angiogenic response to CXCL1/MIP-2, although they respond normally to ..
  45. Podhipleux N, Willman C. Isolation and characterization of the murine C-FGR genomic locus: exons IB-XII. Oncogene. 1995;11:781-4 pubmed
    The c-fgr proto-oncogene is a member of the src family of intracellular protein tyrosine kinases. C-fgr is selectively expressed in hematopoietic cells, particularly in monocytes, neutrophils and natural killer cells...
  46. Vines C, Potter J, Xu Y, Geahlen R, Costello P, Tybulewicz V, et al. Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity. 2001;15:507-19 pubmed
    ..the Syk tyrosine kinase is essential for beta 2 integrin signaling and cell spreading, the Src family kinase Fgr is a negative regulator of this pathway...
  47. Shao B, Yago T, Coghill P, Klopocki A, Mehta D souza P, Schmidtke D, et al. Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin ?L?2. J Biol Chem. 2012;287:19585-98 pubmed publisher
    ..The cytoskeletal independence of PSGL-1-initiated, ?(L)?(2)-mediated slow rolling differs markedly from the cytoskeletal dependence of chemokine-initiated, ?(L)?(2)-mediated arrest. ..
  48. Nelson M, Metz A, Li S, Lowell C, Steele C. The absence of Hck, Fgr, and Lyn tyrosine kinases augments lung innate immune responses to Pneumocystis murina. Infect Immun. 2009;77:1790-7 pubmed publisher
    ..As myeloid cells preferentially express the SFKs Hck, Fgr, and Lyn, we questioned the role of these kinases in innate immune responses to Pneumocystis murina...
  49. Baruzzi A, Berton G. The tyrosine kinase Abl is a component of macrophage podosomes and is required for podosome formation and function. Eur J Immunol. 2012;42:2720-6 pubmed publisher
    ..These findings suggest that podosome disassembly induced by Abl targeting may inhibit podosome-dependent functions such as leukocyte recruitment into inflammatory sites and osteoclast-dependent bone resorption. ..
  50. Continolo S, Baruzzi A, Majeed M, Caveggion E, Fumagalli L, Lowell C, et al. The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization. Exp Cell Res. 2005;302:253-69 pubmed
    b>Fgr participates in integrin signaling in myeloid leukocytes. To examine the role of its specific domains in regulating cell migration, we expressed various Fgr molecules in COS-7 cells...
  51. Goodwin R, Din W, Davis Smith T, Anderson D, Gimpel S, Sato T, et al. Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur J Immunol. 1993;23:2631-41 pubmed
    ..Interaction of 4-1BB with its ligand induces the proliferation of activated thymocytes and splenic T cells, a response which is mimicked on similar cell populations stimulated with an antibody to 4-1BB. ..
  52. Mermel C, McLemore M, Liu F, Pereira S, Woloszynek J, Lowell C, et al. Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood. 2006;108:2562-8 pubmed
    ..Together, these data establish Lyn and Hck as key negative regulators of granulopoiesis and raise the possibility that loss of Src family kinase activation by the d715 G-CSFR may contribute to its hyperproliferative phenotype. ..
  53. Herron B, Liddell R, Parker A, Grant S, Kinne J, Fisher J, et al. A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice. Nat Genet. 2005;37:1210-2 pubmed
    ..Er/+ mice expressed a truncated Sfn protein, which probably contributes to the defects in Er/Er and Er/+ epidermis and to cancer development in Er/+ mice. ..